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Lipid : emulsifier. NEP – Carrier of therapeutic agent. PFOB. lipid. PFOB droplet In water. Long-term goal : mechanism of passive diffusion. Theme : PFOB-NEP atomistic structural details through MD (the first report). PFOB parametrization (United). - PowerPoint PPT Presentation
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Lipid : emulsifierNEP –Carrier of therapeutic agent
lipid
PFOB
PFOB dropletIn water
Long-term goal : mechanism of passive diffusion
Theme : PFOB-NEP atomistic structural details through MD (the first report)
PFOB parametrization (United)
Planar PFOB-NEP interfaceMelittin peptides bounded
Br quenches Trp fluorescence
Pure PFOB-water
Slight overlap ->Stable separation
Dash – bilayerSolid - monolayer
Choline group -> water sideMethyl group -> tail side
Mean PFOB end-to-end distance
Mean orientation of PFOB along the z-axis
Polarization density of the PFOB weak dipole
Rdf of Br around Trp-> direct contact (0.35 nm + 0.33 nm)