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CURRICULUM VITAE LINDA J. SANDELL, Ph.D. EDUCATION 1969 B.A., Zoology, Denver University, Denver, CO 1970 M.S., Biological Sciences, Denver University, Denver, CO 1980 Ph.D., Biochemistry (Dr. Arthur Veis, sponsor), Northwestern University,

Chicago, IL 1980-1982 Postdoctoral, Molecular Biology (Dr. Albert Dorfman, sponsor), University of

Chicago, Chicago, IL PROFESSIONAL EXPERIENCE 1971-1972 Research Assistant, Harvard University Medical School, Boston, MA 1973-1975 Faculty, McHenry County College, McHenry, IL 1982-1987 Assistant Professor, Department of Biochemistry and Department of

Orthopedic Surgery, Rush Medical College, Rush-Presbyterian-St. Luke’s Medical Center (RPSLMC), Chicago, IL

1986-1987 Faculty, Division of Cell Biology, RPSLMC, Chicago, IL 1987-1993 Associate Professor, Department of Orthopaedics, University of Washington,

Seattle, WA 1987-present Visiting Professor, Department of Biochemistry, RPSLMC, Chicago, IL 1988-1993 Adjunct Associate Professor, Department of Biochemistry, University of

Washington, Seattle, WA 1990-1995 Associate Career Research Scientist, VA Medical Center, Seattle, WA 1990-1997 Cell and Molecular Biology Program Graduate Faculty, University of

Washington, Seattle, WA 1993-1997 Professor, Department of Orthopaedics, University of Washington, Seattle,

WA 1993-1997 Adjunct Professor, Department of Biochemistry, University of Washington,

Seattle, WA 1995-2001 Career Research Scientist, VA Medical Center, Seattle, WA 1997-present Member, Siteman Cancer Center, Washington University School of

Medicine 1997-present Professor, Department of Cell Biology and Physiology, Washington

University School of Medicine, St. Louis, MO 2008-present Mildred B. Simon Professor and Director of Research, Department of

Orthopaedic Surgery, Washington University School of Medicine, St. Louis, MO

2009-present Director, NIH p30 Core Center for Musculoskeletal Biology and Medicine 2011 Adjunct Professor, Department of Biomedical Engineering, Washington

University School of Medicine, St. Louis, MO 2014-present Core Team, Foundation for NIH, OA Biomarkers Project HONORS 1980-1982 Committee on Genetics, NIH Fellowship, University of Chicago 1982-1985 Arthritis Foundation Fellowship 1983-1986 Basil O’Connor Starter Grant, March of Dimes Birth Defects Foundation 1984, 1985, 1987 Illinois Arthritis Foundation Grants 1986-1988 March of Dimes Basic Research Grant

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1987-1988 American Heart Foundation Grant - Illinois Chapter 1988-1989 American Heart Foundation Grant - Washington Chapter 1990-1996 Associate Career Scientist Award, VA Medical Center 1991-1994 Program Specialist in Orthopaedics, VA Medical Center 1992 Kappa Delta Award for Basic Research in the Musculoskeletal System,

Orthopaedic Research Society, American Academy of Orthopaedic Surgeons 1993 Charter Member, International Society for Extracellular Matrix 1994-1998 Career Research Scientist Award, VA Medical Center 1994-1999 Membership Chair & Program Chair, Orthopaedic Research Society 1995 Co-Chair, Collagen Gordon Conference 1996 Vice-Chair, Bioengineering and Orthopaedic Sciences Gordon Conference 1998 Chair and Organizer, Bioengineering and Orthopaedic Sciences Gordon

Conference 1998-2002 Advisory Council, National Institute for Arthritis and Musculoskeletal and

Skin Diseases, National Institutes of Health, Washington, D.C. 1999-2000 President, Orthopaedic Research Society 2003 Co-founder, Gordon Conference on the Biology and Pathology of Cartilage 2005 Chair, Cartilage Gordon Conference 2004-2007 President, American Society for Matrix Biology 2005-2007 President, Histochemical Society 2006-2008 Secretary General, Osteoarthritis Research Society International 2010-2012 President, Osteoarthritis Research Society International 2010 Women’s Leadership Award, Orthopaedic Research Society 2011-2013 President, Osteoarthritis Research Society International 2014 Medical/Research Honoree, Arthritis Foundation Silver Ball 2015 Alfred E. Shands Award, Orthopaedic Research Society 2016 Distinguished Investigator Award, Orthopaedic Research Society 2016 Lifetime Achievement Award, Osteoarthritis Research Society International PROFESSIONAL ACTIVITIES International 1994-1997 Research Advisory Board, Shriners Hospital for Crippled Children 1995 Organizing Committee, Fifth International Conference on Mineralized

Tissue, Kohler, WI 1995-1996 Organizing Committee, Pan Pacific Connective Tissue Research Conference 1998 Organizing Committee, International Orthopaedic Research Society Meeting,

Nagoya, Japan, 1998 1999-2001 Organizing Committee, Fourth International Orthopaedic Research Society

Meeting, Rhodes, Greece 2001 1999-2005 Council Member, International Society for Matrix Biology 2001-2008 Board of Directors, Osteoarthritis Research Society International 2007-2009 Secretary General, Osteoarthritis Research Society International 1999,2002,2005 Advisory Board, International Conference on Bone Morphogenetic Proteins 2005-present Faculty of 1000 2006-present International Bone Society 2010-2012 President, Osteoarthritis Research Society International 2009-2014 Director, Osteoarthritis Biomarker Global Initiative National 1986-1987 Medical Advisory Board, Leukemia Research Foundation

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1987 American Cancer Society - Illinois Division 1984-present Ad hoc Reviewer: Journal of Biological Chemistry, Journal of Cell Biology,

Journal of Orthopaedic Research, Connective Tissue Research, Proceedings of the National Academy of Science, and Journal of Bone and Joint Surgery

1986-present Ad hoc Site Review Groups: Pathology B Study Section, National Institute of Alcoholism and Alcohol Abuse, General Medicine A NIH Study Section, Small Business Innovative Research Grant Program, and Searle Grant Program

1991 Abstract Review Committee, American College of Rheumatology 1988-1992 General Medicine A Study Section, National Institutes of Health 1991-1994 Research Scientist Evaluation Committee, VA Medical Center 1991 Council on Research Workshop: “Toward Strengthening Orthopaedic

Research: A Strategy Session to Define the Problems and Plan Future Directions,” American Academy of Orthopaedic Surgeons

1991-1994 Program Specialist in Orthopaedics, VA Medical Center 1992-1996 Grant Review Board, Orthopaedic Research Education Foundation 1993 Organizer, Western Connective Tissue Meeting, Seattle, WA 1994 NIH/NIA Conference: Aging and Musculoskeletal Decline, Santa Barbara,

CA 1994-1996 Organizer AAOS/NIH Workshop on Skeletal Development 1994-1997 Medical Research Advisory Council, VA Medical Center 1996, 1997 Abstract Review Committee, American Society for Bone and Mineral

Research 2001 Scientific Advisory Board, NIH 1st International Conference on Growth

Plate, San Antonio, TX 2001-2002 Chair, Strategic Planning Committee, Orthopaedic Research Society. 2006-2008 Secretary General, Osteoarthritis Research Society International 2000-2005 Council Member, American Society for Matrix Biology 2005-2007 President, American Society for Matrix Biology 2006 Organizer, ASMB Meeting, Nashville, TN 2002-2009 Member, Board of Directors, Osteoarthritis Research Society International

(OARSI); 2003-present, Chair, Scientific Advisory Committee 2007-2009 Secretary General, OARSI 2003-2006 Board Member, Histochemical Society 2007-2008 President, Histochemical Society 2007-2010 Advisory Board to AAOS, Women’s Health Initiative 2008-2011 Chair, OREF Basic Science Grant Review Committee Local 1983-1986 Chairman, Pathobiochemistry Seminar Series, Rush-Presbyterian St. Luke’s

Medical Center (RPSLMC) 1984-1987 Course Director, Molecular Biology (RPSLMC) 1984-1987 Institutional Biosafety Committee (RPSLMC) 1986-1987 University Committee on Research (RPSLMC) 1988-1990, 1993 Grants Review Committee, VA Medical Center 1991-1997 Equipment Committee for Phase IV Renovation, VA Medical Center 1990-1997 Co-Course Director, Biochemistry 405, University of Washington, Seattle,

WA 1991-1997 Research Committee, Department of Orthopaedics, University of

Washington, Seattle, WA

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1991 Ad hoc Search Committee, Department of Medicine, University of Washington, Seattle, WA

1993-1997 Search Committee, Chairman of Department of Biological Structure, University of Washington, Seattle, WA

1993-1997 Space Committee, VA Medical Center, Seattle, WA 1993-1996 Committee on Faculty Affairs, University of Washington; Committee on

Biomedical Research Integrity; Chair, 1995-96 1997-present Member, Siteman Cancer Center, Washington University School of

Medicine, St. Louis, MO 1997-present Education Committee, Department of Orthopaedic Surgery, Washington

University School of Medicine, St. Louis, MO 1998-present Barnes-Jewish Research Advisory Committee, Barnes-Jewish Hospital, St.

Louis, MO 1999-present Scientific Board, ISTO Technologies, St. Louis, MO 2000-present Future of Fundamental Research, Washington University School of

Medicine, St. Louis, MO 1999-present Director, Musculoskeletal Morphology Core Facility (confocal, histology,

etc) 2001-2004 Vice Chair, Executive Committee of the Faculty, Washington University

School of Medicine, St. Louis, MO 2009-2014 Director, Core Center for Musculoskeletal Biology and Medicine 2009-2013 Research Affairs Committee, Washington University PROFESSIONAL SOCIETIES 1980-present American Association for the Advancement of Science 1980-present Sigma Xi Research Society 1983-present Orthopaedic Research Society 1985-present American Society for Cell Biology 1987-present American Society of Biochemistry and Molecular Biology 1996-present The Histochemical Society 1998-present American Academy of Orthopaedic Surgeons 2000-present American Association of Anatomists 2000-present Stem Cell Society 2002-present Osteoarthritis Research Society International 2005-present RNA Society EDITORIAL POSITIONS 1992-1995 Editorial Board, Cartilage and Osteoarthritis 1993-present Deputy Editor, Journal of Orthopaedic Research 1995-present Associate Editor, Journal of Histochemistry and Cytochemistry 1998-present Editorial Board, Calcified Tissue International 1999-present Editorial Board, Arthritis Research 2001-2011 Associate Editor, Connective Tissue Research 2002-present Editorial Board, Journal of Biological Chemistry 2009-present Editor, Musculoskeletal Reviews 2014 – present Editor in Chief, Journal of Orthopaedic Reseach PATENTS • “Assays for Cartilage Synthesis in Osteoarthritis Based on Detection of Type IIA mRNA”.

U.S. Patent #5,541,066. Issued: July 30, 1996

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• “Assays for Cartilage Synthesis in Osteoarthritis Based on Detection of Type IIA Procollagen/Propeptide or Type IIA mRNA”. U.S. Patent #5,541,066. Issued: July 14, 1998

• “Use of Upstream Regulatory Elements in the CD-RAP Locus for Modulating Transcriptional Activity”. U.S. Patent # 06/224,202, Filed 11/20/2000.

• “Trimerizing Polypeptides, their manufacture and use”. U.S. Patent #6,190,886 B1 Issued: February 20, 2001

• “Uncoupled Collagen Synthesis and Degradation Assays”. U.S. Patent # 06/424,941, Filed 11/08/2002.

• “Inhibition of Migration and Induction of Cell Death by the Type II Collagen Animo Propeptide” Filing Date April 5, 2007, Serial No 60/910,361

• Angiogenesis patent PUBLICATIONS 1. Sandell, L. J. Synthesis and characterization of preprocollagen α1(I) chains from chick

calvaria. Ph.D. Thesis, Northwestern University, 1980. 2. Sandell, L. J. & Veis, A. The molecular weight of the cell-free translation product of 1(I)

procollagen mRNA. Biochemical and Biophysical Research Communications 92: 554-562, 1980.

3. Vuorio, E., Sandell, L. J., Kravis, D., Sheffield, V. C., Vuorio, T., Dorfman, A. & Upholt, W. B. Construction and partial characterization of two recombinant cDNA clones for chicken type II collagen. Nucleic Acids Research 10: 1175-1192, 1982.

4. Upholt, W. B., Kravis, D., Sandell, L. J., Sheffield, V. & Dorfman, A. Gene expression during chick limb cartilage differentiation. Progress in Clinical and Biological Research 110B: 175-182, 1982.

5. Sandell, L. J., Yamada, Y., Dorfman, A. & Upholt, W. B. Identification of genomic dna coding for chicken type II procollagen. Journal of Biological Chemistry 258: 11617-11621, 1983.

6. Sandell, L. J., Prentice, H., Kravis, D. & Upholt, W. B. Structure and sequence of the chicken type II procollagen gene: Characterization of the region encoding the carboxyl-terminal telopeptide. Journal Biological Chemistry 259: 7826-7834, 1984.

7. Upholt, W. B., Strom, C. & Sandell, L. J. Structure of the type II collagen gene. Annals of the New York Academy of Sciences 460: 130-140, 1985.

8. Schwartz, D. E., Choi, Y., Sandell, L. J. & Hanson, W. Quantitative analysis of collagen, protein and DNA in fixed or paraffin-embedded and sectioned tissue. Histochemistry Journal 17: 655-663, 1985.

9. Upholt, W. B. & Sandell, L. J. Exon/intron organization of the chicken type II procollagen gene: intron size distribution suggests a minimal intron size. Proceedings of the National Academy of Science 83: 2325-2329, 1986.

10. Goldring, M. B., Sandell, L. J., Stephenson, M. L. & Krane, S. M. Immune interferon suppresses levels of procollagen mRNA and type II collagen synthesis in cultured human articular and costal chondrocytes. Journal of Biological Chemistry 261: 9049-9056, 1986.

11. Boyd, C. D., Weliky, K., Toth-Fejel, S. E., Deak, S. B., Christiano, A. M., Mackenzie, J. W., Sandell, L. J., Tryggvason, K. & Magenis, E. The single copy gene coding for human α1(IV) procollagen is located at the terminal end of the long arm of chromosome 13. Journal of Human Genomics 74: 121-125, 1986.

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12. Sandell, L. J. & Daniel, J. C. Effects of abscorbic acid on collagen mRNA levels in short term chondrocyte cultures. Connective Tissue Research 17: 11-22, 1988.

13. Hering T. M. & Sandell, L. J. Biosynthesis and Cell-free Translation of swarm rat chondrosarcoma and bovine cartilage link proteins. Journal of Biological Chemistry 263: 1030-1036, 1988.

14. Sandell, L. J., Sawhney, R. S., Yeo, K., Poole, A. R., Rosenberg, L. C., Kresse, H. & Wight, T. N. Cell-free translation of mRNA encoding an arterial smooth muscle cell proteoglycan core protein. European Journal of Cell Biology 46: 253-258, 1988.

15. Goldring, M. B., Birkhead, J., Sandell, L. J., Kimura, T. & Krane, S. M. Interleukin-1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes. Journal of Clinical Investigation 82: 2026-2037, 1988.

16. Hering, T. M. & Sandell, L. J. Biosynthesis and processing of bovine cartilage link proteins. Journal of Biological Chemistry 265: 2375-2382, 1990.

17. Ryan, M. C. & Sandell, L. J. Differential expression of a cysteine-rich domain in the amino-terminal propeptide of type II (cartilage) procollagen by alternative splicing of mRNA. Journal of Biological Chemistry 265: 10334-10339, 1990.

18. Goldring, M. B., Birkhead, J., Sandell, L. J. & Krane, S. M. Synergistic regulation of collagen gene expression in human chondrocytes by tumor necrosis factor- alpha (and interleukin-1βeta). Annals of the New York Academy of Sciences 580: 536-539, 1990.

19. Ryan, M. C., Sieraski, M. & Sandell, L. J. The human type II procollagen gene: identification of an additional protein-coding domain and location of potential regulatory sequences in the promoter and first intron. Genomics 8: 41-48, 1990.

20. Sawhney, R. S., Hering, T. M. & Sandell, L. J. Biosynthesis of a small proteoglycan PGII (decorin) by bovine articular chondrocytes and evidence for a pro-core protein. Journal of Biological Chemistry 266: 9231-9240, 1991.

21. Järveläinen, H. T., Kinsella, M. G., Wight, T. N. & Sandell, L. J. Differential expression of small chondroitin/dermatan sulfate proteoglycans PG-I/Biglycan and PG-II/Decorin by vascular smooth muscle and endothelial cells in culture. Journal of Biological Chemistry 266: 23274-23281, 1991.

22. Sandell, L. J. & Hering, T. M. Biosynthesis of multiple proteoglycan link glycoproteins. Trends in Glycoproteins and Glycoscience 3: 10-17, 1991.

23. Schönherr, E., Järveläinen, H. T., Sandell, L. J. & Wight, T. N. Effects of PDGF and TGF-(on the synthesis of a large versican-like chondroitin sulfate proteoglycan by arterial smooth muscle cells. Journal of Biological Chemistry 266: 17640-17647, 1991.

24. Sandell, L. J., Morris, N., Robbins, J. R. & Goldring, M. R. Alternatively spliced forms of type II collagen mRNA define distinct populations of cells during vertebral development: differential expression of the amino-propeptide. Journal of Cell Biology 114: 1307-1319, 1991.

25. Adams, M. E., Huang, D. Q., Yao, L. & Sandell, L. J. Extraction and isolation of mRNA from adult articular cartilage. Analytical Biochemistry 202: 89-95, 1992.

26. Järveläinen, H. T., Iruela-Arispe, M. J., Kinsella, M. G., Sandell, L. J., Sage H. & Wight, T. N. Expression of decorin by sprouting bovine aortic endothelial cells exhibiting angiogenesis in vitro. Experimental Cell Research Beta 203: 395-401, 1992.

27. Qwarnström, E. E., Järveläinen, H. T., Kinsella, M. G., Ostberg, C. O., Sandell, L. J., Page, R. C. & Wight, T. N. Interleukin-β1 (regulation of fibroblast proteoglycan synthesis involves a decrease in versican steady-state mRNA levels. Biochemical Journal 294: 613-620, 1993.

28. Schönherr, E., Järveläinen, H. T., Kinsella, M. G., Sandell, L. J. & Wight, T. N. Platelet derived growth factor and transforming growth factor-beta1 differentially affect the

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synthesis of biglycan and decorin by monkey arterial smooth muscle cells. Arthrosclerosis and Thrombosis 13: 1026-1036, 1993.

29. Boyd, C. D., Pierce, R. A., Schwarzbauer. J. E., Doege, K. & Sandell, L. J. Alternative exon usage is a commonly used mechanism for increasing coding diversity within genes coding for extracellular matrix proteins. Matrix Biology 13: 457-469, 1993.

30. Horton, W. A., Machada., M. A., Ellard, J., Campbell, D., Putnam, E. A., Aulthouse, A. L., Sun, X. & Sandell, L. J. An experimental model of human chondrocyte differentiation. Progress in Clinical and Biological Research 383B: 533-40, 1993.

31. Goldring, M. B., Fukuo, K, Birkhead, J. R., Dudek, E. & Sandell, L. J. Transcriptional suppression by interleukin-1β and interferon gamma of type II collagen gene expression in human chondrocytes. Journal of Cell Biochemistry 54: 85-99, 1994.

32. Sandell, L. J., Sugai, J. & Trippel, S. Expression of collagens I, II, X, and XI and aggrecan mRNA by bovine growth plate chondrocytes in situ. Journal Orthopaedic Research 12: 1-14, 1994.

33. Sandell, L. J., Nalin, A. & Reife, R. The Alternative splice form of type II procollagen mRNA (IIA) is predominant in non-cartilaginous tissues of early mouse embryos. Developmental Dynamics 199: 129-140, 1994.

34. Shapses, S. A., Sandell, L. J. & Ratcliffe, A. Differential rates of aggrecan synthesis and breakdown in different zones of the bovine growth plate. Matrix Biology 14: 77-86, 1994.

35. Yao, L., Moody, C., Schönherr, E., Wight, T. N. & Sandell, L. J. Identification of the proteoglycan versican in aorta and smooth muscle cells by dna sequence analysis, in situ hybridization and immunohistochemistry. Matrix Biology 14: 213-225, 1994.

36. Sandell, L. J. In situ expression of collagen and proteoglycan genes in notochord and during skeletal development and growth. Microscopy Research and Technique 28: 470-482, 1994.

37. Hering, T. M., Kollar, J., Huynh, T. D., Varelas, J. B. & Sandell, L. J. Modulation of extracellular matrix gene expression in bovine high density chondrocyte cultures by ascorbic acid and enzymatic resuspension. Archives of Biochemistry and Biophysics 314: 90-98, 1994.

38. Matyas, J., Adams, M., Huang, D. & Sandell, L. J. Discoordinate gene expression of aggrecan and type II collagen in experimental osteoarthritis. Arthritis and Rheumatism 38: 420-425, 1995.

39. Nalin, A. M., Greenlee, T. K. & Sandell, L. J. Collagen gene expression during development of avian synovial joints: transient expression of types II and XI collagen genes in the joint capsule. Developmental Dynamics 203: 352-362, 1995.

40. Hering, T. M., Kollar, J., Huynh, T. D. & Sandell, L. J. Bovine chondrocyte link protein cdna sequence: interspecies conservation of primary structure and mRNA untranslated regions. Comparative Biochemistry and Physiology 112B: 197-203, 1995.

41. Dietz, U. H. & Sandell, L. J. Cloning of a retinoic acid-sensitive mRNA expressed in cartilage and during chondrogenesis. Journal of Biological Chemistry 271: 3311-3316, 1996.

42. Price, J. S., Nalin, A., Oyajobi, B. I., Frazer, A., Oreffo, R. O. C., Russell, R. G. G. & Sandell, L. J. Chondrogenesis in the regenerating antler tip in red deer: expression of collagen types I, IIA, IIB, and X demonstrated by in situ nucleic acid hybridization and immunocytochemistry. Developmental Dynamics 205: 332-347, 1996.

43. Sandell, L. J. Genes and gene regulation of extracellular matrix proteins: an introduction. Connective Tissue Research 35: 1-6, 1996.

44. Oganesian, A., Zhu, Y. & Sandell, L. J. Localization of type IIA procollagen during chondrogenesis. Pp. 311-313 in molecular and developmental biology of cartilage. Annals of the New York Academy of Sciences 785, 1996.

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45. Sandell, L. J., Dietz, U. H. & Nalin, A. M. mRNA encoding a novel growth regulatory factor is coexpressed with type II procollagen during chondrogenesis. Annals of the New York Academy of Sciences 785: 325-327, 1996.

46. Smith, R. L., Rusk, S. F., Ellison, B. E., Wessells, P., Tsuchiya, K., Carter, D. R., Caler, W. E., Sandell, L. J. & Schurman, D. J. In vitro stimulation of articular chondrocyte mRNA and extracellular matrix synthesis by hydrostatic pressure. Journal of Orthopaedic Research 14: 53-60, 1996.

47. Matyas J. R., Sandell, L. J. & Adams, M. E. Gene expression of type II collagens in chondro-osteophytes in experimental osteoarthritis. Osteoarthritis and Cartilage 5, 99-105, 1997.

48. Bosserhoff, A. K., Kondo, S., Moser, M., Dietz, U. H., Copeland, N. G., Golbert, D. G., Jenkins, N. A., Buettner, R. & Sandell, L. J. Mouse cd-rap/mia gene: structure, chromosomal localization and expression in cartilage and chondrosarcoma. Developmental Dynamics 208: 516-525, 1997.

49. Lefkoe, T. P., Nalin, A. M., Clark, J. M., Reife, R. A., Sugai, J. & Sandell, L. J. Gene expression of collagen types IIA and IX correlates with ultrastructural events in early osteoarthrosis: new applications of the rabbit meniscectomy model. Journal of Rheumatology 24(6): 1155-1163, 1997.

50. Matyas, J. R., Adams, M. E., Huang, D. & Sandell, L. J. Major role of collagen IIB in the elevation of total type II procollagen messenger rna in the hypertrophic phase of experimental osteoarthritis. Arthritis and Rheumatism 40(6): 1046-1049, 1997.

51. Oganesian, A. S., Zhu, Y. & Sandell, L. J. Type II procollagen amino-propeptide is localized in human embryonic tissues. Journal of Histochemistry and Cytochemistry 45(11): 1469-1480, 1997.

52. Buckwalter, J. A., Wright, T. M., Frank, C. B., Martin, R. B., Sandell, L. J. & Trippel, S. B. Scientific credibility requires complete presentation of methods. Journal of Orthopaedic Research 15(2) 161, 1997.

53. Wright, T. M., Buckwalter, J. A., Frank, C. B., Martin, R. B., Sandell, L. J. & Trippel, S. B. Abbreviations, acronyms, and jargon in the journal (editorial). Journal of Orthopaedic Research 15: 323, 1997.

54. Xie, W-F., Kondo, S. & Sandell, L. J. Regulation of the mouse cartilage-derived retinoic acid-sensitive protein (cd-rap) by the transcription factor ap-2. Journal of Biological Chemistry 273(9): 5026-5032, 1998.

55. Isik, F. F., Jang, Y-C., Gibran, N. S., Sandell, L. J. & Schwartz, S. Vitronectin decreases microvascular endothelial cell apoptosis. Journal of Cellular Physiology 175: 149-155, 1998.

56. Raskind, W. H., Conrad, E. U., Matsushita, M., Wijsman, E. M., Wells, D., Chapman, N., Sandell, L. J., Wagner, M. & Houck, J. Evaluation of locus heterogeneity and ext1 mutations in 34 families with hereditary multiple exostoses. Human Mutation 11(3): 231-239, 1998.

57. Chansky, H., Robbins, J. R., Raskind, W. H., Conrad, E. U. & Sandell, L. J. Expression of cartilage extracellular matrix and potential regulatory genes in a new chondrosarcoma cell line. Journal of Orthopaedic Research 16: 521-530, 1998.

58. Kondo, S., Xie, W-F., Cha, S.H., & Sandell, L.J. Discovery and characteristic features of cartilage-derived retinoic acid-sensitive protein (cd-rap). Scanning Electron Microscopy 8: 57-61, 1998.

59. Zhu, Y., Oganesian, A., Keene, D. R. & Sandell, L. J. Type IIA procollagen containing the cysteine-rich amino propeptide is deposited in the extracellular matrix of prechondrogenic tissue and binds to TGF – β1 and BMP-2. Journal of Cell Biology 144: 1069-1080, 1999.

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60. Xie, W-F., Zhang, X., Sakano, S., Lefebvre, V. & Sandell, L. J. Trans-activation of mouse cartilage-derived retinoic acid-sensitive protein by the transacting factor sox9. Journal of Bone and Mineral Research 14(5): 757-763, 1999.

61. Aigner, T., Zhu, Y., Chansky, H. H., Matsen III, F. A., Maloney, W. J. & Sandell, L. J. Reexpression of procollagen type IIA by adult articular chondrocytes in osteoarthritic cartilage. Arthritis and Rheumatism 42: 1443-1450, 1999.

62. Sakano, S., Zhu, Y. & Sandell, L. J. Cartilage-derived retinoic acid-sensitive protein and type II collagen expression during fracture healing are potential targets for sox9 regulation. Journal of Bone and Mineral Research 14 (11): 1891-1901, 1999.

63. Nixon, A. J., Brower-Toland, B. D. & Sandell, L. J. Primary nucleotide structure of predominant and alternate splice forms of equine insulin-like growth factor-I and their gene expression patterns in tissues. American Journal of Veterinary Research 60:1234-1241, 1999.

64. Aigner, T., Loos, S., Muller, S., Sandell, L. J., Unni, K. K., & Kirchner, T. Cell differentiation and matrix gene expression in mesenchymal chondrosarcomas. American Journal of Pathology 156(4): 1327-1335, 2000.

65. Nixon, A. J., Brower-Toland, B. D., & Sandell, L. J. Molecular cloning of equine transforming growth factor-beta 1 reveals a divergent nucleotide structure that codes for a novel bioactive peptide among mammalian species. Journal of Molecular Endocrinology 24: 261-272, 2000.

66. Reardon, A., Sandell, L. J., Jones, C. J. P., McLeod, D. & Bishop, P. localization of type IIA procollagen amino propeptide on the surface of adult bovine vitreous collagen fibrils. Matrix Biology 19: 169-173, 2000.

67. Xie, W-F, Zhang, X. & Sandell, L. J. The 2.2 kb Promoter of cartilage-derived retinoic acid-sensitive protein (cd-rap) controls expression in cartilage and embryonic mammary buds of transgenic mice. Matrix Biology 19: 501-509, 2000.

68. Natsume, N., Matsuyama, Y., Inou, H., Sandell, L. J., Kondo, S., Sumida, K., Kawakami, N., & Iwata, H. Analysis of cd-rap (cartilage-derived retinoic acid-sensitive protein) in cerebrospinal fluid from patients with spinal diseases. Spine 26: 157-160, 2001.

69. Sandell, L. J. & Aigner, T. Cell biology of osteoarthritis. Arthritis Research 3(2): 107-113, 2001.

70. Zhu, Y., McAlinden, A. and Sandell, L.J. Type IIA procollagen in development of the human intervertebral disc: regulated expression of the NH2-propeptide by enzymic processing reveals a unique developmental pathway. Developmental Dynamics 220: 350-362, 2001.

71. Fortier, L. A., Balkman, C. E., Sandell, L. J. & Nixon, A. J. Insulin-like growth factor-I gene expression patterns during spontaneous repair of acute articular cartilage inquiry. Journal of Orthopaedic Research 19: 720-728, 2001.

72. Kondo, S., Cha, S. H., Xie, W-F. & Sandell, L. J. Cytokine regulation of cartilage-derived acid-sensitive protein (CD-RAP) in primary articular chondrocytes: suppression by IL-1β, bFGF, TGFβ and stimulation by IGF-1. Journal of Orthopaedic Research 19: 712-719, 2001.

73. Robinson, D., Hasharoni, A., Oganesian, A., Sandell, L. J., Yayon, A., & Nevo, Z. Role of FGF9 and FGF receptor 3 in osteochondroma formation. Orthopedics 24(8): 783-787, 2001.

74. Zhang, P., McAlinden, A., Li, S., Schumacher, T., Wang, H, Hu, S., Sandell, L. J, & Crouch, E. The amino-terminal heptad repeats of the coiled-coil neck domain of pulmonary surfactant protein d are necessary for the assembly of trimeric subunits and dodecamers. Journal of Biological Chemistry 276(23): 19862-19870, 2001.

75. Fukui, N., Purple, C. R., & Sandell, L. J. Cell biology of osteoarthritis: the chondrocyte’s response to injury. Current Rheumatology Reports 3(6): 496-505, 2001.

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76. Fukui, N., McAlinden, A., Zhu, Y., Crouch, E, Broekelmann, T. J., Mecham, R. P. & Sandell, L. J. Processing of type II procollagen amino propeptide by matrix metalloproteinases. Journal of Biological Chemistry 277(3): 2193-2201, 2002.

77. Moser, M., Bosserhoff, A-K., Hunziker, E. B., Sandell, L. J., Fassler, R., & Buettner, R. Ultrastructural cartilage abnormalities in MIA-CD-RAP deficient mice. Molecular and Cellular Biology 5: 1438-1445, 2002.

78. Davies, S. R., Sakano, S., Zhu, Y. & Sandell, L. J. Distribution of the transcription factors sox9, AP-2, and [Delta]EF1 in adult murine articular and meniscal cartilage and growth plate. Journal of Histochemistry and Cytochemistry 50 (8): 1059-1065, 2002.

79. Yonekawa, M., Kondo, S., Sugiura, H., Kobayashi, K., Watanabe, T., Sandell, L. J., & Iwata, H. Serum cd-rap levels in swarm rat chondrosarcoma. Journal of Orthopaedic Research 20(2): 382-386, 2002.

80. Aigner, T., Kurz, B., Fukui, N. & Sandell. L. J. Roles of chondrocytes in the pathogenesis of osteoarthritis. Current Opinions in Rheumatology 14(5): 578-584, 2002.

81. Saito, S., Kondo, S., Mishima, S., Ishiguro, N., Hasegawa, H., Sandell, L. J., & Iwata, H. Analysis of cartilage-derived retinoic acid-sensitive protein (CD-RAP) in synovial fluid from patients with osteoarthritis and rheumatoid arthritis. Journal of Bone and Joint Surgery 84(7):1066-1069, 2002.

82. Garnero, P., Ayral, X., Rousseau, J-C., Christgau, S., Sandell, L. J., Dougados, M., Pierre, D., & Delmas, M. D. Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis, Arthritis and Rheumatism 46(10) 2613-2624, 2002.

83. McAlinden, A., Crouch, E. C., Bann, J. G., Zhang, P. & Sandell, L. J. Trimerization of the amino propeptide of type IIA procollagen using a 14 amino acid sequence derived from the coiled-coil neck domain of surfactant protein d. Journal of Biological Chemistry 277(43): 41274-41281, 2002.

84. Okazaki, K., Li, J., Yu, H., Fukui, N & Sandell, L. J. CCAAT/enhancer-binding proteins ß and ∆ mediate the repression of gene transcription of cartilage-derived retinoic acid-sensitive protein induced by interleukin-1ß. Journal of Biological Chemistry 277(35): 31526-31533, 2002.

85. McAlinden, A., Zhu, Y., Sandell, L. J. Expression of type II procollagens during development of the human intervertebral disc. Biochemical Society Transactions 30 (part 6): 831-838, 2002.

86. Sandell, L. J., McAlinden, A., Sandell, K. S. The vWFC domain of type IIA procollagen amino-propeptide functions as an antagonist of bone morphogenetic proteins. Journal of Musculoskeletal Neuron Interactions 2(6): 521-523, 2002.

87. Tan, L., Peng, H., Osaki, M., Choy, B. K., Auron, P. E., Sandell, L. J., & Goldring, M. B. Egr-1 mediates transcriptional repression of COL2A1 promoter activity by interleukin-1beta. Journal of Biological Chemistry 278(20): 17688-17700, 2003.

88. McAlinden, A., Smith, T.A. Sandell, L. J., Ficheux, D., Parry, D.A.D. and Hulmes, D.J.S. alpha-helical coiled-coil oligomerization domains are almost ubiquitous in the collagen superfamily. Journal of Biological Chemistry 278: 42200-42207, 2003.

89. Fukui, N., Zhu, Y., Maloney, W. J., Clohisy, J., Sandell, L. J. Stimulation of BMP-2 expression by pro-inflammatory cytokines IL-1 and TNF-(in normal and osteoarthritic chondrocytes. Journal of Bone and Joint Surgery 85: 59-66, 2003.

90. Rousseau, J. C., Zhu, Y., Miossec, P., Vignon, E., Sandell, L. J., Garnero, P., & Delmas, P. D. Serum levels of type IIA procollagen amino terminal propeptide (PIIANP) are decreased in patients with knee osteoarthritis and rheumatoid arthritis. Osteoarthritis and Cartilage 12(6):440-7, 2004.

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91. Huang, Z., Xu, H., & Sandell, L. J. Negative regulation of chondrocyte differentiation by transcription factor AP2. Journal of Bone and Mineral Research 19(2): 245-55, 2004.

92. Gurley, J. M., Wamsley, M. S. & Sandell, L. J. Alternations in apoptosis and epithelial-mesenchymal transformation in an in vitro cleft palate model. Plastic and Reconstructive Surgery 113(3): 907-14, 2004.

93. Davies, S.R., Li, J., Okazaki, K. & Sandell, L. J. Differential regulation of the cdrap gene within a conserved, multigenic housekeeping locus. Genomics 83(4): 667-78, 2004.

94. McAlinden, A., Havlioglu, N and Sandell, L. J. Regulation of protein diversity by alternative pre mRNA splicing with specific focus on chondrogenesis. Embryo Today 72(1): 51-68 2004.

95. Rousseau, J. C., L. J. Sandell, Delmas, P. D., and Garnero, P. Development and clinical application in arthritis of a new immunoassay for serum type IIA procollagen NH2 propeptide. Methods in Molecular Biology 101: 25-37, 2004.

96. El-Zawawy, H., Silva, M, Sandell, L.J. and Wright, R. Functional assessment of mouse femoral physeal closure, Journal of Biomechanics 38 (4): 703-6. 2005.

97. Borrelli J, Zhu Y, Burns M, Sandell L.J., Silva MJ. Cartilage tolerates single impact loads up to half of the joint fracture threshold. Clinical Orthopaedics 426: 266-73, 2004.

98. Li, J. & Sandell, L. J. Transcription factors deltaEF1 and USF1/2 regulate cartilage-derived retinoic acid-sensitive protein gene expression at an e-box site. Journal of Biological Chemistry (in revision)

99. Imamura, T., Imamura, C., Iwamoto, Y., and Sandell, L. J. Transcriptional co-activator CBP/p300 increase chondrocyte Cd-rap gene expression by multiple mechanisms including sequestration of the repressor CCAAT/enhancer-binding protein. Journal Biological Chemistry 280:16625-16634, 2005.

100. El-Zawawy, H., Silva, M, Sandell, L. J. and Wright, R. Ligamentous versus physeal failure in murine medial collateral ligament biomechanical testing. Journal Biomechanics 38(4): 703-6, 2005.

101. Pietka, T.A., Sandell. L.J., Charni, N., Ryan, R., Mistry, J and Garnero, P. Development of a new enzyme immunoassay (EIA) for serum type IIA collagen N-propeptide (PIIANP) and evaluation in patients with rheumatoid arthritis. Arthritis and Rheumatism 64:1906, 2005.

102. McAlinden, A., Havlioglu, N., Liang, L., Davies, SD and Sandell, L. J. Alternative splicing of type II procollagen exon 2 is regulated by the combination of a weak 5' splice site and an adjacent intronic stem-loop cis element. Journal of Biological Chemistry 280:32700-32711, 2005.

103. Posey, K.L., Davies, S., Bales E.S., Haynes, R., Sandell, L. J. and Hetch J.T. In vivo human Cartilage Oligometric Matrix Protein (COMP) promoter activity. Matrix Biology 24(8):539-49, 2005.

104. Okazaki, K., Davies, SR, Imamura, T., and Sandell, L. J. A promoter element of the cd-rap gene is required for repression of gene expression in non-cartilage tissues in vitro and in vivo. Journal of Cell Biochemistry 97(4): 857-68, 2006.

105. Galatz, L.M., Sandell, J.L., Rothermilch, S.Y., Das, R., Mastny, A., Havlioglu, N., Silva, M.J. and Thomopoulos, S. Characteristics of the rat supraspinatus tendon during tendon-to-bone healing after acute injury. Journal Orthopaedic Research 24(3): 541-50, 2006.

106. El-Zawawy, H., Gill, C. Wright, R., and Sandell, L. J. Smoking delays chondrogenesis in a mouse model of closed tibial fracture healing. Journal Orthopaedic Research 24:2150-2158, 2006.

107. Gill, C., Sandell. J. L., El-Zawawy, H., Wright, R. Effect of cigarette smoking on early medial collateral ligament healing in a mouse model. Journal Orthopaedic Research 24 (12): 2141-2149, 2006.

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108. Wright, R., Allen, T., El-Zawawy., Brodt, M., Silva, M., Gill, C., Sandell, L.J., Medial collateral ligament healing in macrophage metalloelastase (MMP-12)-deficient mice. Journal Orthopaedic Research 24(11): 2106-13, 2006.

109. Fukui, N., Ikeda, Y., Ohnuki, T., Hikita, A., Tanaka, S., Yamane, S., Suzuki, R., Sandell, L.J., and Ochi, T., Pro-inflammatory cytokine tumor necrosis factor-α induces bone morphogenetic protein-2 in chondrocytes via mRNA stabilization and transcriptional up-regulation. Journal Biological Chemistry 281:27229-27241, 2006.

110. Davies, S., Chang, L.-W., Patra, D., Xing, X., Posey, K., Hecht, J., Stormo, G., Sandell, L. J., Computational identification and experimental verification of regulatory motifs in cartilage expressed genes. Genome Res 17: 1438-1447, 2007.

111. Sandell, L. J. Modern Molecular Analysis of a Traditional Disease: Progression in osteoarthritis. Arthritis and Rheumatism 56 (8): 2474-7, 2007.

112. Patra, D., Davies, S., Bryan, J., Sandell, L.J. Site-1 protease is essential for endochondral ossification in mice. Journal Cell Biology 179: 687-700, 2007.

113. Jones, K.B., Sponseller, P.D., Erkula, G., Sakai, L., Ramirez, F., Dietz 3rd, H.D., Kost-Byerly, S., Bridwell, K.H. and Sandell, L. Symposium on the musculoskeletal aspects of Marfan syndrome: meeting report and state of the science. Journal of Orthopaedic Research 25(3): 413-22, 2007.

114. Sharif, M., Kirwin, J., Charni, N., Sandell, L.J., Whittles, C., Garnero, P. A 5-yr longitudinal study of type IIA collagen synthesis and total type II collagen degradation in patients with knee osteoarthritis – association with disease progression. Rheumatology 46 938-943, 2007.

115. McAlinden, A., Liang, L., Mukudai, Y., Imamura, T, Sandell, L.J. Nuclear protein TIA-1 regulates COL2A1 alternative splicing and interacts with pre mRNA and genomic DNA Journal of Biological Chemistry 282: 24444-24454,2007.

116. Galatz, L., Rothermich, S., VanderPloeg, K., Petersen, B., Sandell, LJ. and Thomopoulos, S., Development of the supraspinatus tendon-to-bone insertion: localized expression of extracellular matrix and growth factor genes. Journal of Orthopaedic Research 25 (12): 1621-8, 2007.

117. Bay-Jensen, A-C., Andersen, T.L., Charni-Ben Tabassi, N., Kristensen, P.W., Kjaersgaard-Andersen, P., Sandell, L.J., Garner, P., Delaisse, J-M. Biochemical markers of type II collagen breakdown and synthesis are positioned at specific sites in human osteoarthritic knee cartilage. Osteoarthritis and Cartilage 10:1016-1021, 2007.

118. Sandell, LJ, Xing, X., Franz, C., Davies, S., Chang, L., Patra, D., Exuberant expression of chemokine genes by adult human articular chondrocytes in response to IL-1ß. Osteoarthritis and Cartilage 16 (12): 1560-1571, 2008.

119. Fukui, N., Ikeda, Y., Ohnuki, T., Hikita, A., Tanaka, N., Mitomi, H., Katsuragawa, Y., Yamamoto, S., Sawabe, M., Yamane, S., Suzuki, R., Sandell, L.J., and Ochi, T. Regional differences in chondrocyte metabolism in osteoarthritis. Arthritis and Rheumatism. Arthritis and Rheumatism 58 (1): 154-163, 2008.

120. Bay-Jensen, A.C., Andersen, T., Tabassi, N., Kristensen, P., Kjaersgaard-Andersen, P., Sandell, L.J., Garnero, P., Delaisse, J., Biochemical markers of type II Collagen breakdown and synthesis are positioned at specific sites in human osteoarthritic knee cartilage. Osteoarthritis and Cartilage 16 (5): 615 -623, 2008.

121. Imamura, T., Imamura, C., McAlinden, A., Davies, S., Iwamoto, Y. Sandell, L.J. A novel tumor necrosis factor-α responsive CCAAT/enhancer-binding protein site regulates cartilage cd-Rap expression. Arthritis and Rheumatism 58(5): 1366-1376, 2008.

122. Khan, I., Gilbert, S., Caterson, B., Sandell, L. J., Archer, C., Oxidative stress induces expression of osteoarthritis markers procollagen IIA and 3B3(-) in adult bovine articular artilage. Osteoarthritis and Cartilage 16(6):698-707, 2008.

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123. Borrelli, J., Silva, M., Zaegel, M., Franz, C. and Sandell, L.J. A Single high energy impact load causes post traumatic osteoarthritis in young rabbits. Journal Orthopaedic Res Mar 27(3): 347-352, 2009.

124. Sandell, L.J., Xiaoyun, X., Franz, C., Davies, S., Chang, L., and Patra, D., Exuberant expression of chemokine genes by adult human articular chondrocytes in response to IL-1ß. Osteoarthritis and Cartilage, 16 (12); 1560-1571, 2008.

125. Rich, J., Rosova, I., Nolta, J., Myckatyn, T., Sandell, L.J., McAlinden, A., Upregulation of runx2 and osterix during in vitro chondrogenesis of human adipose-derived stromal cells. Biochemical and Biophysical Research Communications 372(1); 230-5, 2008.

126. Roberts, S., Menage, J., Sandell, L.J., Evans, H., Richardson, J., Immunohistochemical study of collagen types I & II and procollagen IIA in human cartilage repair tissue following autologous chondrocyte implantation. The Knee 16 (5) 398-404, 2009.

127. Schmid, G.J., Kobayashi, K., Sandell, L.J. and Ornitz, D.M. Fibroblast growth factor Fibroblast growth factor expression during skeletal fracture healing in mice. Developmental Dynamics 238 (2) 766-74, 2009.

128. Gouttenoire, J., Bougault, C., Foucher-Aubert, E., Perrier, E., Ronziere, M., Sandell, L.J., Zkerlund, E., Mallein-Gerin, F., BMP-2 and TGF-β1 differentially control expression of type II procollagen and α10 and α11 integrins in mouse chondrocytes. European Journal of Cell Biology 89(4): 307-14. 2010

129. Zhang, Z., Xing, X., Hensley, G., Chang, L., Liao, W., Abu-Amer, Y., Sandell, L.J. Resistin induces expression of pro-inflammatory cytokines and chemokines in human articular chondrocytes via transcription and mRNA stabilization. Arthritis Rheumatism, Jul; 62(7): 1993-2003. 2010.

130. Byers-Kraus, V., Nevitt, M. and Sandell, L.J., Summary of the OA Biomarkers Workshop 2009: Biochemical Biomarkers: Biology, Validation and Clinical Studies. Osteoarthritis and Cartilage 18(6): 742-745. 2010.

131. Wang,Z., Bryan, J., Franz, C., Havlioglu,N. and Sandell, L.J. Type IIB procollagen NH2-Propeptide induces death of tumor cells via interaction with interaction with integrins αvB3 and αvB5. Journal Biological Chemistry Jul 285: 2006-20017. 2010.

132. Zhang, Z, Bryan, J., DeLassus, E., Chang, L-W, Liao, W. and Sandell, L.J. CCAATT/Enhancer-binding protein β (C/EBPβ) and nuclear factor kappa B (NF-kB) mediate high level expression of chemokine genes CCL3 and CCL4 by human chondrocytes in response to interleukin-1β (IL-1β). Journal Biological Chemistry,Oct 285: 33092 -33103. 2010.

133. Sanger, TJ, Norgard, EA, Pletscher, LS, Bevilacqua, M., Brooks, VR, Sandell, LJ and Cheverud, JM. Developmental and genetic origins of murine long bone length variation. J. Experimental Zoology B Molecular Development and Evolution. 314B. 2010.

134. Norgard, EA, Sandell, LJ and Cheverud, JM. Differential Igf1 regulation in adolescent LG/J and SM/J mice. (submitted)

135. Hayashi, S., Wang, Z., Bryan, J., Kobayashi, C., Faccio, R., Sandell, L.J. The N- propeptide of Type IIB collagen inhibits function and survival of osteoclasts, but not osteoblasts, via integrin-mediated signaling. Bone., 49(4):644-52. 2011.

136. Meulenbelt, I., Kraus, VB., Sandell, L.J. and Loughlin, J. Summary of the OA Biomarkers Workshop 2010-Genetics and Genomics: New Targets in OA, Osteoarthritis and Cartilage., 19(9):1091-4. 2011.

137. Patra, D., DeLassus, E., Hayashi, S., and Sandell, LJ. Site-1 protease is essential to growth plate maintenance and is a critical regulator of chondrocyte hypertrophic differentiation in postnatal mice. Journal Biological Chemistry, 286: 29227 – 29240 2011.

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138. Brophy, RH., Rai, MF., Zhang, Z., Torgomyan, A., and Sandell, LJ. Molecular analysis of age and sex-related gene expression in meniscal tears with and without a concomitant

anterior cruciate ligament tear. J Bone Joint Surg Am, 94(5): 385-93. 2012. 139. Hashimoto, S., Rai, MF., Janiszak, KL., Cheverud, JM., Sandell, LJ. Cartilage and bone changes during development of post-traumatic osteoarthritis in select during develop ment of post-traumatic osteoarthritis in selected LGXSM recombinant inbred mice. Osteoarthritis Cartilage. 20(6):562-71. 2012. 140. Rai, MF., Hashimoto, S., Johnson, EE., Janiszak, KL., Fitzgerald, J, Heber-Katz E,

Cheverud, JM., Sandell, LJ. Heritability of articular cartilage regeneration and its association with ear wound healing in mice. Arthritis Rheum. 64(7):2300-10. 2012.

141. Wu, P., DeLassus, D., Patra, D., Liao, W., and Sandell, LJ. Effects of serum and compressive loading on the cartilage matrix synthesis and spatiotemporal deposition around chondrocytes in 3D culture. Tissue Engineering. 19 (9-10): 1199-1208. 2013. PMCID:23410025

142. Rai, MF; Sandell, LJ; Cheerud, JM; Brophy, RH. Relationship of age and body mass index to the expression of obesity and osteoarthritis related genes in human meniscus. International Journal of Obesity. Sept; 37 (9):1238-46 2013. PMID: 23318714

143. Rai, MF; Patra, D; Sandell, L.J; Brophy, R.H. Transcriptome analysis of human injured meniscus reveals a distinct phenotype of meniscus degeneration with aging. Arthritis Rheum. Aug; 65 (8): 2090-101. 2013 PMID: 23658108.

144. Hashimoto, S; Rai, MF; Gill, CS; Zhang, Z; Sandell, LJ; Clohisy, JC. Molecular characterization of articular cartilage from young adults with femoral acetabular impingement. Journal of Bone and Joint Surgery. Aug. 21; 95(16):1457-64. 2013 PMID:23965695

145. Wu, P., Holguin, N., Silva, M., Liao, W., Sandell, LJ. Early events following graded mouse knee compressiveloading: cartilage apoptosis, synovial proliferation, ectopic bone formation. Journal Clinical Investigation (pending)

146. Wang, Z., Mueller, J., Rapraeger, A., Sandell, LJ. Inhibition of Angiogenesis by the Cartilage Collagen N-propeptide, PIIBNP. Science. (pending)

147. Hunter, DJ., Eckstein, F., Kraus, V., Losina, E., Guermazi, A., Sandell, LJ., Imaging Biomarker validation and qualification report: sixth OARSI Workshop on Imaging in Osteoarthritis combined with third OA Biomarkers Workshop. Osteoarthritis Cartilage. 2013 Jul; 21(7):939-42. Doi: 10.1016/j.joca 2013.04.014. Epub 2013 PMBID:2363941

148. Sankar, WN., Arden, N., Kim, YJ., Grodzinsky, AJ., Sandell, LJ., Scanzello, C., Siebenrock, KA., Staging of hip osteoarthritis for clinical trials on femoracetabular impingement. J. Am Acad Orthop Surg. 2013; 21 Suppl 1:S33-8. Doi 10.5435/JAAOS-21-07-S33. PMID:23818189

149. Matheney, T., Sandell, LJ., Soucher, K., Lamontagne, M., Grodzinsky, AJ., Peters, CL., Motion analysis, cartilage mechanics, and biology in femoroacetabular impingement: current understanding nand areas of future research. J AM Acad Orthop Surg. 2013;21 Suppl 1:S27-32. Doi: 10.5435/JAAOS-21-07-S27. PMID:23818188

150. Rai, MF; Schmidt, EJ; McAlinden, A; Cheverud, JM; Sandell, LJ. Molecular insight into the association between cartilage regeneration and ear wound healing in genetic mouse models: Targeting new genes in regeneration. G3: Genes, Genomes, Genetics, 2013 Nov 6;3(11):1881-91. doi: 10.1534/g3.113.007302. PMID:24002865

151. Lotz M, Martel-Pelletier J, Christiansen C, Brandi ML, Bruyère O, Chapurlat R, Collette J, Cooper C, GiacovelliG, Kanis JA, Karsdal MA, Kraus V, Lems WF, Meulenbelt I, Pelletier JP, Raynauld JP, Reiter-Niesert S, Rizzoli R, Sandell LJ, Van Spil WE, Reginster JY. Value of biomarkers in osteoarthritis: current status and perspectives. Ann Rheum Dis. Mar; 90. doi: 10.1136/annrheumdis-2013-203726. 2014 PMID: 24534711

152. Sandell, LJ., Novel functions for Type II procollagen. Connect Tissue Res. 2014.

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Jan;55(1): 20-5. Doi: 10.3109/03008207.2013.867340. PMID:24437601 153. Wu, P, Holguin, N, Silva, MJ, Fu, M, Liao, W, Sandell, LJ. Early response of mouse

joint tissues to noninvasive knee injury suggests treatment options. Arthritis and Rheumatology, May;66 (5): 1256-65, doi: 10.1002/art.38375 PMID:24470303. 2014

154. Patra, D, DeLassus, E, McAlinden, A, Sandell, LJ. Characterization of a murine type IIB procollagen-specific antibody. Matrix Biology. 2014. Feb; 34 154-60. PMID 24211541. 2014.

155. Rai, MF, Patra, D, Sandell, LJ, Brophy, RH. Relationship of gene expression in the injured human meniscs to body mass index: A biological connection between obesity and osteoarthritis. Arthritis and Rheumatology. 2014. 66 (8): 2152-64 PMID: 24692131. 2014

156. Hunter DJ, Eckstein F, Kraus VB, Losina E, Sandell LJ, Guermazi A. Imaging biomarker validation and qualification report: sixth OARSI Workshop on Imaging in Osteoarthritis combined with third OA Biomarkers Workshop. Osteoarthritis Cartilage. 2013 Jul;21(7):939-42. doi: 10.1016/j.joca.2013.04.014. Epub 2013 Apr 30. PMID:23639411

157. Patra D, DeLassus E, Liang G, Sandell LJ. Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIB procollagen and down-regulation of cholesterol and lipid homeostasis. PLoS One. Aug. 22 2014: doi: 10.1371/journal.pone 0105674 PMID: 25147951

158. Rai M.F, Sandell LJ. Regeneration of articular cartilage in healer and non-healer mice. Matrix Biol. 39:50-55. 2014 PMID 25173437.

159. Zhang Z, Zhang Z, Kang Y, Hou C, Duan X, Sheng P, Sandell LJ, Liao W. Resistin stimulates expression of chemokine genes in chondrocytes via combinatorial regulation of C/EBPβ and NF-κB. Int J Mol Sci. 2014 Sep 26;15(10):17242-55.

160. Rai MF, Schmidt EJ, Hashimoto S, Cheverud JM, Sandell LJ. Genetic loci that regulate ectopic endochondral calcification in response to traumatic knee injury in mice. Journal of Orthopedic Research, Vol 33 (10): 1412-1423. 2015 PMID: 25989359

161. Takebe K, Rai MF, Schmidt EJ, Sandell LJ. The chemokine receptor CCR5 plays a role in post-traumatic cartilage loss in mice, but does not affect synovium and bone. Osteoarthritis Cartilage. 23:454-61. 2015 PMID:25498590

162. Brophy R, Sandell LJ, Wright R, Rai, MF, Transcriptome Signatures of Meniscal Tears and Articular Cartilage from Knees Undergoing Arthroscopic Partial Meniscectomy May Relate to Early Osteoarthritis. Arthristis Rheumatology (in revision)

BOOK CHAPTERS, REVIEWS AND COMMENTARIES:

163. Sandell, L. J. Molecular biology of proteoglycans and link proteins. Pp. 27-57 in The extracellular matrix: proteoglycans, Wight, T. N. & Mecham, R. (Eds.). Academic Press, New York, 1987.

164. Sandell, L. J. & Boyd, C. A. Conserved and divergent sequence and functional elements within collagen genes. Pp. 1-56 in Extracellular matrix genes, Sandell, L. J. & Boyd, C. A. (eds.). Academic Press, New York, 1990.

165. Sandell, L. J. Goldring, M. B., Zamparo, O., Wu, J-T., & Yamin, R. Molecular biology of type II collagen: new information in the gene. Pp. 81-94 in Articular cartilage and osteoarthritis, Kuettner, K. E., Schleyerbach, R., Peyron, J. Q. & Hascall, V. C. (eds.). Raven Press, 1992.

166. Sandell, L. J. & Hering, T. M. Small leucine-rich proteoglycans: prelude to a function. Pp. 13-22 in Trends in glycoscience and glycotechnology 5, 1993.

167. Sandell, L. J. Anti-inflammatory medications: do they prevent or retard joint disease?

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Pp. 583-596 in The shoulder: a balance of mobility and stability, Matsen III, F. A., Fu, F. H. & Hawkins, R. J. (eds.). American Association of Orthopaedic Surgeons Press, Rosemont, IL, 1993.

168. Sandell, L. J. Chansky, H., Zamparo, O. & Hering, T. Molecular biology of cartilage proteoglycans and link protein. Pp. 117-130 in Osteoarthritic disorders, Kuettner, K. E. & Goldberg, V. (Eds.). American Association of Orthopaedic Surgeons Press, Rosemont, IL, 1995.

169. Sandell, L. J. Molecular biology of collagens in normal and osteoarthritic cartilage. Pp. 131-146 in Osteoarthritic disorders, Kuettner, K. E. & Goldberg, V. (Eds.). American Association of Orthopaedic Surgeons Press, Rosemont, IL, 1995.

170. Sandell, L. J. Extracellular matrix. Pp. 310-315 in Molecular biology and biotechnology, Meyers, R. A. (Ed.). VCH Publishers, New York, 1995.

171. Sandell, L. J. Isolation and analysis of rna from connective tissues and cells. Pp. 329-351 in Extracellular matrix: a practical approach, Haralson, M. A. & Hassell, J. R. (Eds.).

IRL Press, Oxford, 1995. 172. Sandell, L. J. Extracellular matrix. Pp. 278-284 in Encyclopedia of Molecular Biology.

Volume 2, R. A. Meyers (Ed.). VCH Press, New York, 1999. 173. Ayad,S. &Sandell, L. J. Collagens of the intervertebral disc: structure, function, and

changes during aging and disease. Pp. 539-556 in Low back pain: a scientific and clinical overview, Weinstein, J. N. & Gordon, S. L. (Eds.). American Association of Orthopaedic Surgeons Press, Rosemont, IL, 1996.

174. Sandell, L. J. Genes and gene regulation of extracellular matrix proteins: an introduction. Connective Tissue Research, 34-35: 1-6, 1996.

175. Sandell, L. J., Zhu, Y., Keene, D. & Oganesian, A. Type IIA procollagen may function to present bone morphogenetic proteins during endochondral bone formation. Pp. 30-322 in Extracellular matrix-cell interactions: molecules to diseases, Ninomiya, Y., Olsen, B. R. & Ooyama, T. (Eds.). Japan Scientific Societies Press, Tokyo/S. Karger, Basel, 1998.

176. Sandell, L. J., Zhu, Y., & Oganesian, A. Collagen gene expression as markers for skeletal development, disease, and repair. Pp. 37-52 in Skeletal growth and development: clinical issues and basic science advances, Buckwalter, J., Ehrlich, M. G. Sandell, L. J., & Trippel, S. (Eds.). American Association of Orthopaedic Surgeons Press, Rosemont, IL, 1998.

177. Sandell, L. J., Nalin, A. M., & Zhu, Y. Collagens in joint tissue. Pp. 121-133 in Biology of the synovial joint, Archer, C., Caterson, B., Benjamin, M. & Ralphs, J. (Eds.). Harwood Academic Publishers, 1999.

178. Sandell, L. J. & Adler, P. Developmental patterns of cartilage. Frontiers in bioscience, 4: 731-742, 1999.

179. Sandell, L. J. Genes and gene expression. In Orthopaedic gene therapy, Evans, C. H. and Scully, S. (Eds.). Clinical Orthopaedic and Related Research 379S: S9-S16, 2000.

180. Sandell, L.J. & Hering, T. Biochemistry, molecular and cell biology of articular cartilage in osteoarthritis. Pp. 115-144 in Osteoarthritis, 3rd Edition, Moskowitz, R. M., Howell, D. S., Altman, R. D., Buckwalter, J. A., Goldberg, V. M. (eds.), W. B. Saunders Company, Philadelphia, PA, 2001.

181. Sandell, L.J. & Silva, M.J. What’s new in orthopaedic surgery. Journal of Bone and Joint Surgery 83A:1117-1124, 2001.

182. Silva, M.J. and Sandell, L.J. What’s new in orthopaedic research. Journal of Bone and/Joint Surgery 84-A(8): 1490-1496, 2002.

183. Aigner, T., Kurz, B., Fukui, N. and Sandell, L.J. Roles of chondrocytes in the pathogenesis of osteoarthritis. Current Opinions in Rheumatology 14(5): 578-584, 2002.

184. McAlinden, A., Zhu, Y., Sandell, L.J. Type IIA procollagen NH2-propeptide functions as

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an antagonist of bone morphogenetic proteins. Pps. 5-16 in Hascall, V and Kuettner, K, Eds., The Many Faces of Osteoarthritis. Birkhaeuser Publishing Co., Ltd., 2002.

185. Sandell, L.J. and Towler, D. Transcription of bone and cartilage genes. Current Opinion in Orthopaedics 13:375-381, 2002.

186. McAlinden, A., Zhu, Y. and Sandell, L.J. Expression of type II procollagens during development of the human intervertebral disc. Biochemical Society Transactions, 30 (part 6): 831-838, 2002.

187. Li, J. and Sandell, L.J. Transcriptional regulation of cartilage-specific genes in chondrogenesis. Pp. 21-34 in Rosier, R. and Evan, C.H., Eds., Molecular Biology in Orthopaedics. American Association of Orthopaedic Surgeons Press, Rosemont, IL. 2003.

188. Sandell, L. J. and Okazaki, K. Overview of connective tissue genes: extracellular matrix gene regulation. in future directions on osteoarthritis research, Clinical Orthopaedic and Related Research, 427 Supl; S123-128. 2004.

189. McAlinden, A., Havlioglu, N and Sandell, L. J. Regulation of protein diversity by alternative pre-mRNA splicing with specific focus on chondrogenesis. Birth Defects Research C Embryo Today, 72(1): 51-68. 2004.

190. Sandell, L.J., Bone morphogenetic protein and transforming growth factor- β interactions with extracellular matrix in health and disease. Current Opinions in Orthopaedic 17:412- 417. Lippincott Williams & Wilkins 2006.

191. Sandell, L.J. Anabolic factors in degenerative joint disease. Current Drug Targets, 8 (2): 359-65. 2007.

192. Sandell, L.J. Hering, T., and Heinegard, D. Biochemistry and molecular and cell biology of articular cartilage in osteoarthritis in Osteoarthritis, 4th Edition, Moskowitz, R., Ed. (4): 73-106. 2007.

193. Sandell, L. J. Molecular aspects of cartilage repair. Cells Tissues Organs (in press). 194. Fukui, N and Sandell, L.J. Anabolic aspects of cartilage repair in topics in bone biology,

vol. 4. bone and osteoarthritis, Bronner, F. and Farach-Carson, M.C., Eds, Springer- Verlag, 97-108, 2007.

195. Goldring, M. and Sandell, L.J. Transcriptional control of chondrocyte gene expression. in O: inflammation and degradation: a continuum. Buckwalter, J., Lotz, M., Stoltz, J.F., Biomedical and Health Research, 70:118-142. 2007.

196. Sandell, L.J. Modern molecular analysis of a traditional disease: progression in osteoarthritis. Arthr Rheum, 56 (8): 2474-7. 2007.

197. Sandell, L.J. Multiple hereditary exostosis, ext genes, and skeletal development, a. the journal of bone and joint surgery, J Bone Joint Surg, 91: 58-62. 2009.

198. Sandell, L.J. Metabolism of chondrocytes in osteoarthritis: why all this activity? J b. Musculoskeletal Neuronal Interact, 8 (4): 307. 2009.

199. Sandell, L.J. Obesity and osteoarthritis: is leptin the link? Arthr Rheum, 60 (10): c. 2858-60. 2009.

200. Sandell, L.J. Etiology of osteoarthritis: the role of development of synovial joints. Nature Reviews Rheumatology, 8 (2):77-89. 2011.

201. Rai, MF and Sandell, L.J. Forecast for Osteoarthritis Stem Cell Therapy, HyperGuide d. 2011).

202. Salter, D., Buckwalter, W., Sandell, L.J. Pathology of Osteoarthritis. OARSI OA Primer – online - 2011.

203. Rai, MF and Sandell, L.J. Inflammatory Mediators: Tracing links between Obesity and Osteoarthritis. Critical Reviews in Eukaryotic Gene Expression. 21 (2): 131-42. 2012.

204. Patra, D., Sandell, L.J. Biomarkers Human. Journal of Knee Surgery.24 (4):241-9. 2011. 205. Patra, D., Sandell, L.J. Recent Advances in Biomarkers. Current Opinion in 206. Rheumatology. 23(5):465-70. 2011.

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207. Patra, D., Sandell, L.J. Anti-angiogenesis and anti-cancer agents in cartilage. Expert Reviews in Molecular Medicine. Jan 19; 14:e10. Doi 10.1017/erm. 2012.3

208. Sandell, LJ Biomarkers in osteoarthritis. Hospital for Special Surgery J. 2012: Feb 8(1): 33-4. Doi 10.1007/s11420-011-9246-8. Epub 2012 Feb. 23. PMID 22529768

209. Gill, C., Takebe, K., Sandell, LJ. Hip and Acetabulum. Book Ed. Parvis 210. Hunter, D., and Sandell, L.J. OA Biomarkers 3rd Workshop – Imaging. Osteoarthritis and

Cartilage. (in press). 211. Rai MF, Sandell LJ. Genetic variability in the response to injury. In Post-

Traumatic Arthritis: Pathogenesis, Diagnosis and Management. Editors: Steven Olson and Farshid Guilak. Springer, 2014. (In press).

212. Rai M.F, Sandell LJ. Regeneration of articular cartilage in healer and non-healer mice. Matrix Biol. 39:50-55. 2014 PMID: 25173437.

213. Rai MF, Sandell, L.J. Emerging concepts in gene therapy for Osteoarthritis. Journal of American Acad Orthopedic Research. (10): e56-7 doi:10.5435/JAAOS-D-15-00339 Epub 2015. PMID: 26320162.

214. Rai MF, Schmidt EJ, Hashimoto S, Cheverud JM, Sandell LJ. Genetic loci that regulate ectopic calcification in response to knee trauma in LG/J by SM/J advanced intercross mice. J Orthop Res. 2015 Oct;33(10):1412-23. doi: 10.1002/jor.22944. Epub Jun 19. PMID: 25989359.

BOOKS 215. Sandell, L. J. & Boyd, C. (eds.), Extracellular matrix genes. Academic Press, New York,

1990. 216. Buckwalter, J., Ehrlich, M. G., Sandell, L. J. & Trippel, S. (eds.), Skeletal growth and

development: clinical issues and basic science advances. American Association of Orthopaedic Surgeons Press, Rosemont, IL, 1998.

217. Sandell, L.J. and Grodzinsky, A. (eds.). Clinical applications of tissue engineering in musculoskeletal diseases. American Academy of Orthopaedic Surgeons Press,

Rosemont, IL 2004. 218. Sandell, L.J. Celebrate orthopedic research. Journal of Orthopedic Research. 33 (4): 449.

2015. PMID: 25810306 219. Sandell, L.J. Editorial. Journal of Orthopedic Research. 34 (1):7. doi: 10.1002/jor:23124.

2016. PMID 26750725 ABSTRACTS (not included) INVITED PRESENTATIONS AND SEMINARS 1. Fogarty Conference on Collagen Genes, National Institutes of Health, Bethesda, MD, 1982 2. Collagen Gordon Conference, l981, l983, l985, l989 3. Biology of Connective Tissue Meeting, St. Louis, MO, 1982 4. Gordon Conference on Bones and Teeth, l982, l983 5. Proteoglycan Gordon Conference, l984, l986; session chairman, l988 6. Orthopaedic Research Society Meetings, l984, l985, l986, l987, l988, 1989, 1990, 1991,

1992, 1993, 1994; Session Chair, 1988-1994; Symposium on Molecular Biology of Cartilage Collagens, 1989.

19

7. Midwest Connective Tissue Meetings, l984, l985; session chairman, l987 8. Department of Pathology, University of Chicago, l984 9. Department of Anatomy, University of California at San Francisco, l984 10. Department of Biochemistry, Rutgers University, l984. 11. Department of Oral Biology, Northwestern University Medical School, l984, l987 12. University of Manchester, Manchester, England, l984 13. Gordon Conference on Biological Regulatory Molecules, l985 14. Monash University, Melbourne, Australia, l985 15. Royal Children’s Hospital Melbourne, Australia, l985 16. Department of Pathology, University of Washington, l986; Department of Orthopaedics,

1987; Department of Biochemistry, l988 17. Syntex, Palo Alto, CA, 1987 18. Department of Medicine, VA Medical Center, Memphis, TN, l987 19. Department of Medical Genetics, Shriners Hospital for Crippled Children, Houston, TX,

l987 20. Department of Biochemistry, Chicago Medical School, l987 21. Department of Medicine, Massachusetts General Hospital, l987 22. Department of Biochemistry, University of Washington, Seattle, WA, 1988 23. Southern Connective Tissue Research Society, Shriners Hospital, Tampa, FL, l989 24. Vascular Biology Seminar Series, Department of Pathology, University of Washington,

Seattle, WA, l989 25. Symposium, “Genes Encoding Cartilage Matrix Proteins” Orthopaedic Research Society,

l989 26. Western Connective Tissue Society, University of New Mexico, Albuquerque, NM, 1989 27. Naprosyn Research Conference, Laguna Niguel, CA, l989 28. Shriners Hospital Research Division, Portland, OR, 1989 29. Merck, Sharpe and Dohme Research Laboratories, Rahway, NJ, 1989 30. Miles Research - Arthritis and Autoimmune Disease Institute, West Haven, CO, 1989 31. -38. Department of Surgery; Department of Medicine; Section of Hemology, 3x;

Department of Biochemistry; Medical Genetics Course; Department of Immunology/Microbiology, Rush-Presbyterian-St. Luke’s Medical Center, Chicago, IL, 1984-1987

32. Gordon Conference on Collagen, 1989 33. Pan Pacific Connective Tissue Societies Symposium, Cairnes, Australia, 1989 34. Gordon Conference on Proteoglycans, 1990 35. Zymogenetics, Seattle, WA, 1990 36. Third International Conference on the Molecular Biology and Pathology of Matrix,

Philadelphia, PA, 1990 37. Gordon Conference on Orthopaedics, 1991 38. Departments of Orthopaedics and Pathology, University of Minnesota, 1991 39. Department of Surgery, Robert Wood Johnson Medical School, 1991 40. Conference on Advances in Mineral Metabolism, Snow Mass, CO, 1991 41. International Workshop on Articular Cartilage Biochemistry, Wiesbaden, Germany, 1991 42. Gordon Conference on Elastin, 1991 43. Third International Jerusalem Symposium on Connective Tissue, Jerusalem, Israel, 1991 44. Department of Biochemistry, Monash University, Melbourne, Australia, 1991 45. Roland D. Pinkham, M.D. Basic Science Lectureship, Swedish Hospital, Seattle, WA,

1991. 46. American Collage of Rheumatology, Boston, MA, 1991 47. Department of Oral Biology, Northwestern University Dental School, Chicago, IL, Dr. A.

Veis, 1991.

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48. Institute for Molecular Science of Medicine, Aichi Medical University, Japan. Dr. Koji Kimata, 1992.

49. Fifth Symposium on Cartilage Metabolism, Nagoya, Japan, 1992. 50. Kobe Woman’s College, Kobe, Japan, Dr. K. Sugahara, 1992. 51. Osaka University, Osaka, Japan, Dr. T. Kimura, 1992. 52. Kennedy Institute for Rheumatology, Dr. Tim Hardingham, 1992. 53. Institute of Molecular Medicine, Erlangen, Germany, Dr. Klaus von der Mark, 1992. 54. Department of Orthopaedics, Case Western Reserve University Medical School,

Cleveland, OH, Dr. Victor Goldberg, 1992. 55. Department of Biology, University of New Mexico, Albuquerque, NM, Dr. Kate Vogel,

1992 56. Department of Orthopaedics, Case Western Reserve University Medical School,

Cleveland, OH, Dr. R. Moskovitz, 1992 57. Osteoarthritis Sciences, Boston, MA, 1992 58. Science in Medicine Lecture, University of Washington, Seattle, WA, 1992. 59. Midwest Connective Tissue Meeting, 1992. 60. Northwest Center for Research on Women, Seattle, WA, 1993. 61. Thirty-Ninth Annual Meeting of the Orthopaedic Research Society, San Francisco, CA,

1993. 62. West Coast Connective Tissue Society, La Conner, WA, organizer, 1993. 63. Thirty-Seventh Annual Meeting of the Japanese Rheumatism Society, Nagoya, Japan,

1993. 64. Tokyo Symposium on Osteoarthritis, Tokyo, Japan, Dr. Masayuki Shinmei, 1993. 65. Kobe Symposium on Arthritis, Kobe, Japan, Dr. Tsukasa Matsubara, 1993. 66. Department of Orthopaedics and Biochemistry, College of Physicians and Surgeons of

Columbia University, Dr. Anthony Ratcliffe, 1993. 67. Department of Molecular Biology, Mount Sinai Medical Center, New York, NY, Dr.

Francesco Ramirez, 1993. 68. Department of Surgery, Robert Wood Johnson Medical Center, UMDNJ, Dr. Charles

Boyd, 1993. 69. Telios Pharmaceuticals, La Jolla, CA, Dr. Robert Spiro, 1993. 70. University of California, San Diego, La Jolla, CA, Dr. David Amiel, 1993. 71. Fourth International Conference on Matrix Biology, Philadelphia, PA, 1993. 72. Gordon Research Conference on Collagen, New London, NH, 1993. 73. Forty-Sixth Annual Symposium on Fundamental Cancer Research, Houston, TX, 1993. 74. Department of Biochemistry, Rush Medical School, Chicago, IL, 1993 75. Fortieth Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, 1994. 76. Gordon Collagen Conference Chair’s Meeting, Los Angeles, CA, 1994. 77. Shriners Hospital for Sick Children Board Meeting, New Orleans, LA, 1994. 78. Cornell University, Ithaca, NY, 1994 79. New Horizons in Osteoarthritis, Monterey, CA, 1994. 80. West Coast Connective Tissue Society, Albuquerque, NM, 1994. 81. Bristol-Myers Zimmer Meeting, Warsaw, IN, 1994. 82. Fifth International Conference on the Molecular Biology and Pathology of Matrix,

Philadelphia, PA, 1994. 83. Gordon Conference on Basement Membranes, New London, NH, 1994. 84. Gordon Conference on Bioengineering and Orthopaedic Science, New London, NH,

1994. 85. Second European Conference on Biology of Cartilage and Bone, Giens, France, 1994. 86. Medical Research Planning Council, VA Medical Center, Houston, TX, 1994. 87. Forty-First Annual Meeting of the Orthopaedic Research Society, Orlando, FL, 1995.

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88. Shriners’ Hospital for Sick Children Board Meeting, Orlando, FL, 1995. 89. Medical Research Planning Council, VA Medical Center, Washington, D.C., 1995. 90. Latest Discoveries in Arthritis Research Forum, Seattle, WA, 1995. 91. Western Connective Tissue Society, Berkeley, CA, session chair and speaker, 1995. 92. Gordon Conference on Bones and Teeth, Meriden, NH, session chair and speaker, 1995. 93. Gordon Collagen Conference, Sawyer Collage, NH, co-chair, 1995. 94. Molecular and Developmental Biology of Cartilage, Bethesda, MD, 1995. 95. Fifth International Conference on Chemistry and Biology of Mineralized Tissue, State of

the Art: Gene Regulation and Structure, Kohler, WI, session chair and speaker, 1995. 96. Institute for Molecular Biologicals, Bayer Corporation, New Haven, CT, 1995. 97. Midwest Connective Tissue Society, Chicago, IL, session chair and speaker, 1995. 98. New Horizons on Low Back Pain Conference, San Diego, CA, session chair and speaker,

1995. 99. Department of Orthopaedic Surgery, Washington University School of Medicine, St.

Louis, MO, Dr. Richard Gelberman, Dr. Louis Avioli, 1996. 100. NIAMS Round Table Discussion on Future of Orthopaedic Research, Bethesda, MD, Dr.

Stephen Katz, 1996. 101. Cartilage Meeting, Nagoya, Japan, 1996. 102. Okayama University Dental School, Okayama, Japan, 1996 103. School of Medicine, Wayne State University, Chicago, IL, 1996. 104. Gordon Conference on Bioengineering and Orthopaedic Science, New London, NH,

session chair and speaker, 1996. 105. Symposium on the Biology of the Synovial Joint, University of Wales, Cardiff, 1996. 106. Orthopaedic Research Society, New Horizons in Tissue Engineering, 1997. 107. Skeletal Morphogenesis and Growth, AAOS/NIH Meeting, Orlando, FL, 1997. 108. Collagen Gordon Conference, New London, NH, session chair, 1997 109. Developmental Biology of the Skeleton, Chicago, IL, organizer, Dr. Rocky Tuan, 1997. 110. Distinguished Lecturer in Orthopaedics Sciences and Rheumatology, University of North

Carolina, Chapel Hill, NC, 1998. 111. Graduate Program in Cellular and Molecular Medicine and Comparative Medicine,

Cornell University, Ithaca, NY, 1998. 112. Gordon Conference on Bioengineering and Orthopaedic Science, Andover, NH,

organizer, 1998. 113. Tissue and Cell Engineering Euroconference, Santa Margherita, Italy, 1998. 114. Third Combined Meeting of Orthopaedic Research Societies, Hamamatsu, Japan,

workshop organizer, 1998. 115. Thirteenth Annual Orthopaedic Research Meeting of the Japanese Orthopaedic

Association, Special Lecturer, Nagoya, Japan, 1998. 116. Midwest Connective Tissue Workshop, Chicago, IL, co-organizer, 1998. 117. Advanced Tissue Sciences, La Jolla, CA, 1999. 118. Orthopaedic Research Society, Anaheim, CA, workshop organizer, 1999. 119. Rush-Presbyterian St. Luke’s Hospital, Department of Biochemistry, Chicago, IL, 1999. 120. Monsanto Corporation, St. Louis, MO, March 1, 1999. 121. International Symposium on Molecular Cell Biology of Cartilage Development and

Repair, Lake Tahoe, CA, June 2-6, 1999. 122. University of New Mexico School of Medicine, October 8, 1999. 123. Pennsylvania State College of Medicine, Cell & Molecular Biology Seminar Series,

Hershey, PA, October 13, 1999. 124. Pennsylvania State College of Medicine, Department of Orthopaedics and Rehabilitation

Grand Rounds, Hershey, PA, October 14, 1999. 125. Baylor College of Dentistry, Dallas, TX, November 1, 1999.

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126. Midwest Connective Tissue Workshop, Session chair, Chicago, IL, November 5-6, 1999. 127. Gene Therapy Workshop, Association of Bone and Joint Surgeons, Tampa, FL,

December 15, 1999. 128. Kennedy Institute of Rheumatology, London, England, February 18, 2000. 129. Osteoarthritis Initiative, NIAMS, Bethesda, MD, February 27-28, 2000. 130. Instructional Course Lecture, Development, Structure and Function of the Synovial Joint,

AAOS, Orlando, FL, March 15-19, 2000. 131. Roche Bioscience, Palo Alto, CA, April 13-14, 2000. 132. International Cartilage Repair Society, 3rd Symposium, Gothenburg, Sweden, April 27-

29, 2000. 133. International Society for Matrix Biology, Philadelphia, PA, June 15-17, 2000. 134. The Aircast Foundation, Rutherford, CA, October 17-18, 2000. 135. Aventis Pharmaceuticals, Global Osteoarthritis Expert Advisory Panel, Chicago, IL,

October 24, 2000. 136. Third Workshop on Heritable Disorders of Connective Tissue, Bethesda, MD, November

16-18, 2000. 137. ORS Grant Writing Workshop, Rosemont, IL, March 17-18, 2001. 138. Shriners Hospital for Crippled Children, Tampa, FL, April 18, 2001. 139. 2nd Cartilage Weekend in Slovenia, Portoroz, Slovenia, May 5-6, 2001. 140. 4th Combined Meeting of the Orthopaedic Research Society, Rhodes, Greece, June 1-3,

2001. 141. 1st International Conference on the Growth Plate, San Antonio, TX, June 15-19, 2001. 142. The Many Faces of Osteoarthritis, Granbalakken, Lake Tahoe, CA, June 22-27, 2001. 143. Collagen Gordon Conference, New London, NH, July 29-August 3, 2001. 144. AAOS/NIH Molecular Biology in Orthopaedics Workshop, Scottsdale, AZ, September 7-

9, 2001. 145. 2001 American College of Rheumatology Basic Research Conference: Cartilage and

Bone Biology, San Francisco, CA, October 10-12, 2001. 146. First International McCaig Research Conference, Calgary Canada, March 22-25, 2002. 147. Osteoarthritis Initiative Conference, Toronto, Canada, April 19-21, 2002. 148. Biochemical Society, Cardiff, Wales, July 15-24, 2002. 149. Musculoskeletal Biology and Bioengineering Gordon Research Conference, Andover,

NH, July 28-August 2, 2002. 150. Sun Valley Hard Tissue Workshop, Sun Valley, ID, August 4-8, 2002. 151. SICOT/SIROT 2002, XXII World Congress, San Diego, CA August 23-30, 2002. 152. OARSI World Congress, Sydney, Australia, September 22-25, 2002. 153. 4th International Conference on Bone Morphogenetic Proteins, Sacramento, CA, October

17-21, 2002. 154. Shriners Hospital, Portland, OR, October 23, 2002. 155. American College of Rheumatology Annual Scientific Meeting, New Orleans, LA,

October 24-29, 2002. 156. University of Michigan, Ann Arbor, MI, November 25-26, 2002. 157. Histochemical Society Meeting, April 10-15, 2003. 158. International Conference on Inflammopharmacology, Edinburgh, Scotland, April 22-24,

2003. 159. Pfizer, June 5, 2004 160. Histochemistry and Cytochemistry Meeting, San Diego, CA, July 24-28, 2004 161. GRC Musculoskeletal Biology & Bioengineering, Andover, NH, Invited Speaker, July

25-30, 2004 162. GRC Post-transcriptional Gene Regulation, Andover, NH, August 8-13, 2004

23

163. 5th International Conference on Bone Morphogenic Proteins, Nagoya, Japan, Keynote Speaker, September 12-16, 2004

164. 2nd National Meeting ASMB, San Diego, CA, November, 10-13, 2004 165. OARSI Meeting Chicago, IL, Keynote Speaker , December 2-5, 2004 166. Hospital for Special Surgery, Dr. Francesco Ramirez, New York, December 10-14, 2004

Cleveland Clinic, Cleveland, OH, ,January 26-28, 2005 167. ORS Annual Meeting, Washington, DC, February 19-23, 2005 168. Vanderbilt University, Nashville, TN, April 18, 2005 169. Lily Research, Indianapolis, IN, April 19, 2005 170. HCS Meeting, Nortdwijkerhout, The Netherlands, April 25-30, 2005 171. 3rd Cartilage Weekend, Portoroz, Slovenia, Keynote Speaker, May 6-7, 2005 172. June 5-9, 2005, GRC Cartilage Biology and Path, Ciocco, Italy, Organizer 173. July 7-8, 2005, Osteoarthritis Symposium, Smith and Nephew, Memphis, Tennessee 174. July 24-29, 2005, Collagen GRC, New London, NH, Speaker 175. August 4, 2005, National Marfan Found Conference, St. Louis, MO, Organizer 176. September 11-12, 2005, University of Iowa SCOR, Iowa City, IA 177. September 15-18, 2005, AAOS Research Symposium, Lincolnshire, IL 178. September 28, 2005, NIAMS Osteoarthritis Biomarkers Network Steering Committee

Meeting, Washington, DC. 179. October 11, 2005, Musculoskeletal Disorder Core Center Symposium/Retreat University

of Pennsylvania, PA, Philadelphia, PA, Visiting Professor and Keynote Speaker. 180. November 13-19, 2005, Annual ACR Meeting, San Diego, CA, Invited Speaker 181. December 8-11, 2005, OARSI World Congress, Boston, Massachusetts, Invited Speaker 182. March 3-5, 2006, 19th Annual Meeting of the Japanese Society of Cartilage Metabolism,

Tokyo, Japan, Keynote Speaker 183. March 18-22, 2006, ORS 52nd Annual Meeting, Chicago, IL, Speaker 184. March 24-26, 2006, OARSI Board Meeting and Symposium, New York, NY 185. April 26-27, 2006 NYU Division of Rheumatology, New York, NY, Visiting Professor 186. May 9, 2006, UAB Matrix Research Center, Birmingham, AL , Visiting Professor 187. June 11-15 , 2006, International Workshop on The Skeletal Growth Plate, Portland

Oregon, Invited Speaker 188. June 24–30, 2006, ECM VII Cartilage and Joint Repair, Switzerland, Invited Speaker 189. July 11-14, 2006 Musculoskeletal Biology Tissue Engineering, Boston & DC, Invited

Speaker 190. July 23-28, 2006 Musculoskeletal GRC Conference, Boston 191. August 21-28, 2006 Histochemistry 2006 Conference, Waikoloa, Hawaii, Invited

Speaker 192. October 26-28, 2006 AAOS Research Symposium, Toronto, Canada, Invited Speaker 193. November 1-4, 2006 American Society for Matrix Biology, Nashville, TN, President 194. November 10- 11, 2006 OA Biomarker Meeting, Washington, DC. Committee Member 195. December 7-10, 2006, Prague, Czech Republic, Osteoarthritis Research Society, Invited

Speaker 196. January 19 -20, 2007, San Diego, CA, American Society for Biochemistry and Molecular

Biology, Invited Speaker 197. February 11-14, 2007, San Diego, CA, 53rd Annual Orthopaedic Research Society,

Invited Speaker 198. March 4-9, 2007, Ventura Beach, CA, Gordon Research Conference, Invited Speaker 199. March 23-24, 2007, New York, OARSI Meeting, Committee Member 200. April 17- 23, 2007, Seattle, OA Symposium & Inflammation Research Conference,

Invited Speaker 201. April 28 – May 2, 2007, Washington, DC, Experimental Biology 2207, Invited Speaker

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202. May 10 – 12, 2007, St. Louis, MO, Musculoskeletal Tumor Society, Invited Speaker 203. May 27, 2007, Philadelphia, Symposium on New Drug Targets for Osteoarthritis, Glaxo-

Smith-Kline 204. June 12 - 13, 2007, Barcelona, OARSI Board Meeting, Committee Member 205. July 17- 19, 2007, Memphis, TN, Symposium – University of Tennessee, Invited Speaker 206. July 22 – 27, 2007, New London, NH, Gordon Research Conference, Invited Speaker 207. September 7 – 10, 2007, Chicago, Segal North American Osteoarthritis, Committee

Member 208. September 21, 2007, Rosemont, IL, AAOS Womens Health Meeting, Committee

Member 209. November 15 – 17, 2007, New York, Chief Scientist Pro-Tempore, Hospital for Special

Surgery, Cornell Medical Center, Alumni Associations 89th Annual Meeting, Invited Speaker

210. December 6-9, 2007, Fort Lauderdale, FL, OARSI 2007 World Congress, Invited Speaker

211. January 22-23, 2008, Washington, DC, NIAMS/Board of Scientific Councilors, Committee Member

212. February 25-26, 2008, Seattle, Histochemical Society Meeting, President 213. March 2-5, 2008, AAOS/ORS, San Francisco, CA, Invited Speaker & Moderator 214. April 5-9, 2008, Histochemical Society & Experimental Biology 2008, San Diego, CA,

Invited Speaker & Moderator 215. April 10-12, 2008, OARSI Board Meeting, Philadelphia, PA, Board Member 216. April 20-23, 2008, 17th International Rheumatology Symposium, Sapporo, Japan, Invited

Speaker 217. May 2-4, 2008, Segal North American Osteoarthritis, Chicago, IL, Invited Speaker 218. May 7-8, 2008, Duke University, Raleigh/Durham, Invited Speaker 219. June 1-2, 2008, NIH Board Meeting, Bethesda, MD, Board Member 220. June 23-28, 2008, Imaging Workshop of Osteoarthritis, Boston, Ma, Invited Speaker 221. August 3-6, 2008 Sun Valley Workshop Skeletal Tissue Biology, Invited Speaker 222. August 28-29, 2008, Univ of Kansas City, Kansas City, KS, Invited Speaker 223. September 8, 2008, Tim Hardingham Symposium, Cardiff Wales, Invited Speaker 224. September 18-21, 2008, OARSI World Congress, Rome, Italy, Board Member 225. October 12-14, 2008, Histochemical Society Board Meeting, Seattle WA, Board Member 226. October 21, 2008, WHIAB Meeting, Chicago, IL, Invited Speaker 227. November 6-8, 2008, Shriners Workshop, Minneapolis, MN, Invited Speaker 228. November 10-12, 2008, DBBS (Marc), Tuscon, AZ, Invited Speaker 229. December 6-10, 2008, ASMB 2008 Conference, San Diego, CA, Moderator 230. December 11-24, 2008, AOSSM Post Conference, New Orleans, Invited Speaker 231. January 15-16, 2009, OARSI 2009 Board Meeting, Paris, Board Member 232. January 23-24, 2009, OREF Peer Review Meeting, Orlando Florida, Board Member 233. February 22-28, 2009, ORS/AAOS Conference, Las Vegas, Nevada, Invited Speaker 234. March 4-12, 2009, 22nd Annual Meeting of the Japanese Society, Nagoya, Japan, Invited

Speaker 235. March 13, 2009, Department of Orthopaedic Surgery, Kobe, Japan. 236. April 22-27, 2009, OA Biomarkers, Bethesda, MD, Organizer 237. May 20, 2009, Genzyme Site Visit, Boston, MA, Invited Speaker 238. June 10-13, 2009, Congress of Rheumatology, Copenhagen Denmark, Invited Speaker 239. August 23-24, 2009, WHIAB, Rosemont, IL, Board Member 240. September 10-13, 2009, OARSI 2009 World Congress, Montreal, CA, Board Member 241. October 1-5, 2009, Arthritis (SNOW) Meeting, Chicago, IL, Invited Speaker 242. October 13-14, 2009, OA Biomarkers Consortium, Boston, MA, Invited Speaker

25

243. October 21-24, 2009, Bone & Joint Global Network, Washington, DC, Invited Speaker and organizer

244. November 10-11, 2009, University of Pennsylvania Center for Musculoskeletal Disorders, Philadelphia, PA, Invited Speaker and Scientific Advisory Board

245. November 12-13, 2009, NIH S10 Reviews, Chicago, IL, Reviewer 246. January 28-29, 2010, OARSI Board Meeting, Paris, Board Member 247. March 3, 2010, Arthritis Foundation Meeting, Washington, DC, Invited Speaker 248. March 5-10, 2010, AAOS/ORS Conference, New Orleans, Moderator 249. March 24, 2010, University of Delaware, Newark Delaware, Invited Speaker 250. April 27-28, 2010, OAI Steering Committee Meeting, Chicago, Board Member 251. May 9-10, 2010, Mayo Clinic, Rochester, Minnesota, Invited Speaker 252. June 3-5, 2010, Canadian Connective Tissue Conference, Toronto, Invited Speaker 253. June 27-28, 2010, NIAMS Review Meeting, Bethesda, MD, Reviewer 254. August 1-6, 2010, Gordon Conference, Andover, NH, Moderator 255. Sept. 23-26, 2010, OARSI 2010 World Congress, Brussels, Belgium President 256. Sept. 26, 2010, International Cartilage Repair Society, Barcelona, Spain, Invited Speaker 257. Sept. 30, 2010, WHIAB, Rosemont, IL, Board Member 258. Oct. 4-6, 2010, OARSI China Forum, China, Invited Speaker 259. Oct. 11-13, 2010, University of Hong Kong, Hong Kong, Invited Speaker 260. Oct. 15-16, 2010, Arthritis Foundation RSC Meeting, Atlanta, GA, Peer Review 261. Oct. 23-27, 2010, ASMB Conference, Charleston, SC, Invited Speaker 262. Nov. 4-5, 2010, OA Biomarkers, Atlanta, GA, Organizer & Moderator 263. Nov. 29-Dec. 1, 2010, NIAMS Review, Bethesda, MD, Reviewer 264. Dec. 2-5, 2010, AOSSM Post Joint Conference, New Orleans, Invited Speaker 265. Jan. 13-16, 2011, Orthopaedic Research Society, Long Beach, CA, Moderator 266. Feb. 9-15, 2011, OARSI Board Meeting, New York, President & Moderator 267. Mar. 4-6 2011, Japanese Society of Cartilage, Fukuoka, Japan, Invited Speaker 268. Mar. 6-11, 2011, Gordon Conference Biology & Pathology, Ventura, CA, Moderator &

Speaker 269. Mar. 25-27, 2011, Arthritis (SNOW), Chicago, IL, Invited Speaker 270. Mar. 30-31, 2011, NIAMS Review Committees (P30, P50, & ACTS), Washington, DC,

Reviewer and Co-Chair 271. April 14-16, 2011, Extracellular Matrix in Health & Disease Conference, Boston, MA,

Invited Speaker 272. April 29-30, 2011, Arthritis Foundation Research Strategy Committee Meeting, Chicago,

IL, 273. June 15-18, 2011, Hospital for Special Surgery Conference, New York, Invited Speaker 274. July 8-13, 2011, Translation Opportunities for the Heritable Disorders of Connective

Tissue, Portland, Oregon, Invited Speaker 275. July 17-22, 2011, Gordon Research Conference – Collagen, New London, NH, Invited

Speaker 276. August 21-26, 2011, Gordon Research Conference – Angiogenesis, Newport, RI, Invited

Speaker 277. Sept. 13-19, 2011, OARSI 2011 World Congress, San Diego, CA, President 278. Oct. 20-24, 2011, University of California, Sacremento, CA, Invited Speaker 279. Nov. 30- Dec. 7, 2011, COA2011 Congress, Beijing China, Invited Speaker & Moderator 280. January 19-22, 2012, BMJD Congress, Barcelona, Spain, Session Chairman & Invited

Speaker 281. February 3-8, 2012, Orthopaedic Research Society, San Francisco, CA, Moderator 282. March 21-23, 2012, NICHD,NIH/ PDEGEN Meeting/Site Visit, Washington, DC,

Committee Member/ Reviewer

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283. April 23-30, 2012, OARSI 2012 World Congress, Barcelona, Spain, President 284. May 9-10, 2012, FAI/AAOS Symposium, Chicago, IL, Organizer & Invited Speaker 285. May 12-15, 2012, ICRS Congress, Montreal, CA, Moderator 286. June 25-28, 2012, Upenn Editorial Board, Philadelphia, PA, Board Member 287. July 11-15, 2012, OA Biomarkers, Hilton Head,SC, Oragnizer & President 288. August 5-10, 2012. Gordon Research Conference, Andover, NH, Moderator 289. September 9-15, 2012, Shriners, Portland, Speaker 290. October 24-25, 2012, OARSI Board Meeting, Chicago, IL, President 291. October 26-29, 2012, Arthritis (SNOW), Chicago, IL, Invited Speaker 292. November 1-4, 2012, MHE Research Conference, Philadelphia, PA, Committee Member/

Reviewer 293. November 10-14, 2012, ASMB Conference, San Diego, CA, Invited Speaker 294. January 26-29, 2013, ORS, San Antonio,TX, Invited Speaker & Moderator 295. February 21, 2013, Tuft University, Boston, MA, Invited Speaker 296. April 18-21, 2013, OARSI World Congress, Philadelphia, PA, President & Moderator 297. April 30, 2013, NIAMS, Review Committees, Washington, DC, Reviewer 298. May 10 -11, 2013, Korean College of Rheumatology, Seoul, Korea, Invited Speaker 299. May 19- 24, 2013, Gordon Conference Matrix Metalloproteinases, Lucca, Italy, Invited

Speaker 300. May 31 – June 1, 2013, ICRS Conference, Tallinn, Estonia, Moderator 301. June 4-5, 2013, IICS Board Meeting, Bethesda, MD, Invited Guest 302. June 26 – 27, 2013, Rochester University, Rochester, NY, Invited Speaker 303. October 12-19, 2013, University of Finland, Panel Reviewer, Oulu, Finland 304. October 26-30, 2013, College of Rheumatology Conference, San Diego, CA, Invited

Speaker 305. October 30 – 31, 2013, OARSI Board Meeting,San Diego, CA, Past-President, Board

Member 306. November 6-8, 2013, University of Oulu RAE2013, Cophenhagen, Panel Reviewer 307. November 24-28, 2013, Musculoskeletal Disease Panel, Berlin Panel Reviewer 308. March 15-19, 2014, ORS, New Orleans, Speaker & Moderator 309. April 24-27, 2014, OARSI World Congress, Paris, France, Speaker & Moderator 310. April 29-30, 2014, CORT External Advisory Meeting, Rochester, NY, Committee

Member 311. October 22-23, 2014, OARSI Board Meeting, Chicago, IL, Committee Member 312. October 24 -26, 2014, SNOW Conf Meeting, Chicago, IL, Invited Speaker 313. February 5- 9, 2015, Musculoskeletal Developmental Biology Conference, Cancun,

Mexico, Invited Speaker 314. March 16- 17, 2015, Core External Advisory Board Meeting, Rochester, NY, Committee

Member 315. March 22 – 26, 2015, Gordon Conference, Galveston, TX, Invited Speaker 316. March 27 – 31, 2015, 2015 ORS Conference, Las Vegas, NV, JOR Editor & Moderator

& Workshop 317. April 16-18, 2015, NYU Musculoskeletal Center, New York, NY, Invited Speaker 318. April 25 – May 6, 2015, OARSI World Congress Conf, Seattle, WA, Board Member 319. May 8 – May 11, 2015, ICRS Conf, Chicago, IL Invited Speaker 320. Sept. 23-25, 2015, ORS Board Meeting, Orlando, FL, Committee Chair 321. Oct. 20 – 23, 2015, 30th Annual Research Mtg – Japan, Tokyo, Japan – Invited Speaker 322. Nov. 11 – 13, 2015, NIAMS Musculoskeletal P30 Core Center Grant Review, Bethesda,

MD, Reviewer 323. Dec. 8-10, 2015 - NIDCR Board of Scientific Counselors, Bethesda, MD, Reviewer 324. February 25, 2016 – Arthritis Foundation Accelerating Osteoarthritis Clinical Trials,

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Atlanta, GA, Panel Reviewer 325. March 5-8, 2016, ORS Annual Meeting, Orlando, FL, Committee Chair 326. March 21, 2016, CORT External Advisory Meeting, Rochester, NY, Committee Member

CURRENT FUNDING P30 AR057235 Sandell (PI) 05/01/09-03/31/2019 NIH/NIAMS $369,804/yr “Core Center for Musculoskeletal Diseases” The goal of this project is to develop a Core Center in Musculoskeletal Disease at Washington University to bring together a substantial group of investigators from our large University complex to form an identifiable unit in the research community: Research in Musculoskeletal Diseases. R01 AR063757 Sandell (Co- PI); Cheverud (Co-PI) 10/01/2013 – 08/31/2016 NIH/NIAMS $265,790/yr “Genetics of Cartilage Reneneration and Osteoarthritis” The overall goal of this grant is to establish the cartilage repair and osteoarthritis phenotype in the various recombinant inbred and advanced intercross lines to map the genetic variation for these phenotypes. K99 AR064837 Sandell (Mentor); Rai (PI) 05/01/2014 – 04/30/2016 NIH/NIAMS $81,181/ yr (direct costs) The focus of this grant proposal is to understand the genetic, molecular and cellular differences in cartilage regeneration and degeneration in a set of healer and non-healer mouse strains from recombinant inbred lines. R01 AR066590 (Sandell, Patra) 04/01/2015 – 03/31/2020 NIH/NIAMS $220,000 The Dynamic Range of Site-1 Protease in Skeletal Development The goal of this project is to investigate the role(s) of Site-1 protease in cartilage and bone development through the discovery of additional substrates for site-1 protease in chondrocyte and osteoblast lineages. PENDING Sandell (PI); 07/01/2015 – 06/30/2018 DoD OR140206 $245,900 Prediction of Joint Degeneration after Common Injuries to the Knee The objectives are to (1) assess whether early changes in serum and urine biomarkers predict the progression of osteoarthritis (OA)-like changes in patients with combined meniscus and anterior cruciate ligament (ACL) tears, and (2) determine if early molecular events from the injured joint tissue predict early changes indicative of initiation/progression of OA. Wickline (PI); Sandell (PI);Pham, C. (PI); Rai (Co-I) 12/01/2015 – 11/30/2019 NIH/NIAMS – R01 $154,642 Inhibition of NF-KB with Sirna/Peptide Nanoparticles for Osteoarthritis Treatment Organization

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The objective of these studies is (1) formulation of single/multiplexed siRNA agents for NF-kB knockdown in chondrocytes, (2) in vivo suppression of osteoarthritis with peptide siRNA nanocomplexes in pre-clinical models and (3) to determine whether NF-kB suppression modulates autophagy in osteoarthritis. Completed Funding R01 AR36994 Sandell (PI) 09/01/2005 – 08/31/2011 ($204,428/yr) NIH/NIAMS “Regulation of Gene Expression in Cartilage” The specific aims of this study are to 1) investigate the role of negative transcription factors during chondrogenesis, specifically AP-2, ∂ef-1 and C/EBP 2) investigate the regulation of the type ii procollagen pre-mRNA alternative splicing switch that occurs during chondrogenesis. 3) determine the function of developmentally-expressed type IIA procollagen protein isoform in vivo. 4) investigate the mechanism of IL-1ß and TNF-α induction of BMP-2 in adult chondrocytes. R01 AR 053224 Cheverud (PI); Sandell (Co-investigator) 07/01/2006 – 06/30/2011 ($486,600/yr) NIH/NIAMS “Genetic Variation in Murine Long Bone Growth and Development” The goal of this project is to determine the genes that cause bone growth. RC2 AR058978-01 Cheverud (Co- PI); Sandell (Co-PI) 09/25/2009 – 08/31/2011 ($685,000/yr) NIH/NIAMS “Genetic Mouse Models of Cartilage Healing” The overall goal of the Grand Opportunity grant proposal is to establish the cartilage repair phenotype in the parental healing and non-healing animals and 12 R1 inbred strains and the repair phenotype in the individuals in the Advanced Intercross F40 generation. Sandell, LJ (PI) ($40,000) 02/04/2010- 05/09/2011 Bear Cub/ Washington University – Office of Technology Management “Inhibition of Migration and Induction of Cell Death by the Type II Collagen Amino Propetide” We have demonstrated chondrosarcoma tumor and breast cancer cell killing activity in vitro and anti-angiogenic activity in vitro and in vivo. In preliminary studies using two in vivo cancer models, we have promising results in reducing tumor size with our reagent. At this stage animal studies with commercially prepared reagent are necessary to provide the proof for the concept that our reagent will reduce tumors in animals. We have chosen to target the chondrosarcoma and breast cancer tumors because (1) we have extensive preliminary data in vitro and in vivo and (2) there is a significant need for adjuvant treatment for both breast cancers and chondrosarcoma. Novartis Pharmaceuticals – Sandell (PI) 05/01/2010 – 08/31/2011 ($99,000.00) Effect of Dexamethasone on Tracheal Cartilage R01 DK065789-06A1 Long (PI); Sandell (Co-Investigator) 12/01/2008 – 04/30/2012 ($250,000) NIH/NIDDK “Indian Hedgehog Signaling in Osteoblast Differentiation”

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The main goal of this project is to understand the mechanism by which Ihh regulates the osteoblast lineage. 1 U13 AR057296 Sandell (PI) 04/01/2009 - 03/31/2013 ($150,000/yr) NIH/NIAMS Biomarkers for Osteoarthritis The goal of this project is to support the continuation of the very successful set of meetings of the OA Biomarkers Network. Three meetings are supported: April 23-24, 2009; November 4-5, 2010 and spring 2012. Brophy (PI) ); Sandell (Co-Investigator) 07/01/2011 – 06/30/2013 ($50,000) OREF Young Investigator Grant “Metabolic Activity of the Meniscus: Potential Marker for and Predictor of Osteoarthritis” The goal of this project is to measure the metabolic activity of the meniscus with known candidate genes and start to assess the relationship of meniscal activity to patient age, chondrosis and serum biomarkers. R01 AR 050847 Sandell (PI) 09/01/2007 – 08/31/2013 ($160,199/yr) NIH/NIAMS “Cis Regulatory Motifs in Adult Articular Chondrocytes” The major goals of this project is to investigate the molecular basis for the severe chondrodysplasia caused by the lack of the enzyme Site-1-protease in cartilage and the lack of endochondral bone formation. R01 AR 045550 Sandell (PI) 03/01/1998 - 08/31/2015 NIH/NIAMS ($203,148/yr) No Cost extension “Function and Regulation of CD-RAP” The specific aims of this study are to: 1) determine the mechanism of the CD-RAP 183-bp regulatory domain that confers tissue specificity; 2) determine the role of additional negative/positive regulatory elements; 3) screen for and analyze co-regulators; 4) computational identification and functional validation of novel regulatory motifs. Fidia Farmaceutici S.p.A. Sandell(PI); Rai(Co-PI) 01/30/2014 – 12/31/2015

$189,355 Study of early of and late responses to intra-articular treatment of the knee joint following compressive loading In this proposal we wish to test if the treatment of a joint injury with hyaluronic acid suppresses events that lead to post-traumatic osteoarthritis in mice