Keystone Symposia on Molecular and Cellular Biology is a nonprofit organization headquartered in Colorado, USA directed and supported by the scientific community.

Plenary Session Topics: > Hypothalamic Inflammation, ER Stress and

Mitochondrial Function> Addiction and Reward in the CNS Control of Metabolism> Nutrient Sensing and the Brain> Dissecting CNS Control of Metabolism> Gut-Brain Interactions in the Control of Systemic

Metabolism> Neurocircuitry and Systemic Control of Metabolism> Glia Cells and CNS Control of Metabolism

Abstract & Scholarship Deadline: November 14, 2012Late-Breaking Abstract Deadline: December 19, 2012Early Registration Deadline: January 17, 2013

Note: Scholarships are available to students and postdoctoral fellows and require a brief application and submission of an abstract. Short talk speakers will also be selected from abstracts. Early registration saves US$150 on later fee. Information shown is subject to possible change.

www.keystonesymposia.org/13C6

Keystone Symposia on Molecular and Cellular Biology is a nonprofit organization headquartered in Colorado, USA directed and supported by the scientific community.

1.970.262.1230 | 1.800.253.0685 (US & Canada)

Keystone Symposia is pleased to present

Neuronal Control of Appetite, Metabolism and Weight Scientific Organizers: Tony K.T. Lam and Matthias H. Tschöp

March 17–22, 2013 | Fairmont Banff Springs | Banff, Alberta | Canada

Obesity and type 2 diabetes associate with a disruption in energy, glucose and lipid homeostasis. New, exciting developments continue to indicate

a key role for the Central Nervous System in the homeostatic control of systemic metabolic processes and ultimately body weight. A goal of this meeting is to bring together basic and clinical scientists from academia and the pharmaceutical industry studying neuronal control of appetite, metabolism and body weight or related complementary fields (such as addiction/reward, cellular stress and inflammation) to share novel insights with relevance for human obesity, diabetes and metabolic disease. The meeting seeks to trigger progress toward a novel and improved model, which integrates existing knowledge with novel discoveries on central nervous system mechanisms activated by hormones or nutrients that regulate systemic metabolism. Ultimately, the goal is to provide the research in this field with a valuable new tool with combined relevance for both basic science and clinical research.

SUNDAY, MARCH 17Arrival and Registration

MONDAY, MARCH 18Welcome and Keynote Address *Matthias H. Tschöp, Helmholtz Zentrum München and TechnischeUniversität München, GermanyRichard D. Palmiter, HHMI/University of Washington, USADeciphering Neural Circuits Controlling Appetite

Hypothalamic Inflammation, ER Stress and Mitochondrial Function *Tony K.T. Lam, Toronto General Research Institute, CanadaDongsheng Cai, Albert Einstein College of Medicine, USAHypothalamic Autophagy, Inflammation and Neurodegeneration inObesity and DiabetesUmut Ozcan, Harvard Medical School, USAHypothalamic Inflammation, ER Stress and Metabolic ControlJens C. Brüning, Max Planck Institute for Metabolism Research,GermanyInsulin Receptors in the Brain: Where Do They Matter?Eleftheria Maratos-Flier, Beth Israel Deaconess Medical Center, USACentral Actions of FGF21 Eduardo A. Nillni, Brown University, Rhode Island Hospital, USAShort Talk: Obesity Induces Hypothalamic Endoplasmic ReticulumStress and Impairs Proopiomelanocortin (POMC) Post-TranslationalProcessing

Workshop 1: Is the CNS Still a Relevant Pharmaceutical Target forMetabolic Disease? *Mads Tang-Christensen, Novo Nordisk A/S, Denmark*Ruth E. Gimeno, Eli Lilly and Company, USATargeting TrkB/BDNF for the Treatment of Metabolic DisordersBirgitte S. Wulff, Novo Nordisk A/S, DenmarkSafety and Efficacy of a Long Acting alpha-MSH Analogue,MC4-NN2-0453, in Overweight to Obese But Otherwise HealthySubjectsGiles S.H. Yeo, University of Cambridge, UKIs the Obesity Related FTO a Viable Therapeutic Target?Andrew C. Adams, Eli Lilly and Company, USAFGF21: From the Brain to Adipose and Back AgainLora K. Heisler, Rowett Institute, University of Aberdeen, UK5-HT2C Receptor Agonist: a New Obesity Treatment

Addiction and Reward in the CNS Control of Metabolism *Kevin L. Grove, Novo Nordisk, USAHarvey J. Grill, University of Pennsylvania, USADo Separate Sets of Neurons Control for the Satiation, theMotivational, and the Association-Based Preference Effects of Leptin? Tamas L. Horvath, Yale School of Medicine, USAA Role for the Arcute Nucleus in Reward and Complex BehaviorsDana M. Small, Yale University School of Medicine, USAMetabolic Control of Neural Circuits Underlying Food RewardLearning in Humans

Sandeep Sharma, Montreal Diabetes Research Center, University deMontreal, CanadaShort Talk: Saturated High-Fat Diets Are Anxiogenic and ElicitPro-Inflammatory Signaling in Brain Reward Circuitry

Poster Session 1

TUESDAY, MARCH 19Nutrient Sensing and the Brain *Robert H. Eckel, University of Colorado Denver, Anschutz MedicalCampus, USADaniele Piomelli, University of California, Irvine, USAThe Role of Endocannabinoids in the Role of Food IntakeTony K.T. Lam, Toronto General Research Institute, CanadaNutrient Sensing in the Gut and the BrainBradford B. Lowell, Beth Israel Deaconess Medical Center, USANeurocircuits Regulating Energy BalanceSabrina Diano, Yale University School of Medicine, USAGlucose Sensing and Hypothalamic Neuropeptide ProcessingEglantine Balland, Monash University, AustraliaShort Talk: Tanycytes of the Median Eminence Gate Leptin Transportinto the Hypothalamus RAJ KAMAL SRIVASTAVA, YLL School of Medicine, NationalUniversity of Singapore, SingaporeShort Talk: Genetic Deletion of the CB1 Receptor fromDopamine-beta-Hydroxylase Expressing Cells Makes Mice Sensitiveto Stress-Induced Obesity

Workshop 2: Challenges of the Publishing Process: How to Writea Scientific Masterpiece *Ushma Savla Neill, Journal of Clinical Investigation & MolecularMetabolism, USAIain Patten, Scientific Writing Consultant, SpainRandy S. Levinson, Cell Press, USANikla Emambokus, Cell Press, USA

Dissecting CNS Control of Metabolism I *Gregory James Morton, University of Washington, USAKendra K. Bence, Pfizer Inc., USAThe Role of Protein Tyrosine Phosphatases in Neuronal Control ofEnergy Balance Christoph Buettner, Mount Sinai School of Medicine, USANovel Roles of Brain Insulin Signaling in Regulating Whole BodyNutrient Partitioning and Innate ImmunityDomenico Accili, Columbia University, USAFoxO1 Targets Regulating Energy Balance in the Central NervousSystemToshiya Kojima, University of Tokyo, JapanShort Talk: SUMOylation of Krüppel-Like Factor 5 Controls FoodIntake by Suppressing AgRP Expression on Contact with FoxO1 inHypothalamic Neurons

* Session Chair † Invited but not yet accepted Program current as of October 21, 2021. Meal formats are based on meeting venue. For the most up-to-date details, visit https://www.keystonesymposia.org.

KEYSTONE SYMPOSIAon Molecular and Cellular Biology

Neuronal Control of Appetite, Metabolism and Weight (C6)March 17-22, 2013 • Fairmont Banff Springs • Banff, AB, Canada

Scientific Organizers: Tony K.T. Lam and Matthias H. TschöpSponsored by AVEO Oncology

Discounted Abstract & Scholarship Deadline: November 14, 2012 / Late-Breaking Abstract Deadline: December 19, 2012 / Early Registration Deadline: January 17,2013

Poster Session 2

WEDNESDAY, MARCH 20Gut-Brain Interactions in the Control of Systemic Metabolism *Darleen A. Sandoval, University of Colorado, USADaniel J. Drucker, Lunenfeld-Tanenbaum Research Institute, CanadaThe Biology of Incretins: Gut-Brain-Cardiovascular ConnectionsRémy G. Burcelin, Institute of Molecular Medicine, FranceThe Role of GLP-1 on the Gut-Brain AxisHans Rudolf Berthoud, Pennington Biomedical Research Center,USABariatric Surgery on CNS Control of MetabolismRandy J. Seeley, University of Michigan, USAMolecular Targets for Bariatric SurgeryChen Liu, University of Texas Southwestern Medical Center, USAShort Talk: PPARgamma Signaling in Vagal Sensory NeuronsRegulates Energy BalanceGary J. Schwartz, Albert Einstein College of Medicine, USAShort Talk: Mediobasal Hypothalamic beta-3 Adrenergic ReceptorSignaling Regulates Energy Intake and Utilization

Workshop 3: CNS Control of Metabolism: Hot Topics *Thierry Alquier, University of Montreal-Montreal Diabetes ResearchCenter, Canada*Diego Perez-Tilve, University of Cincinnati, USAPawan Gulati, University of Cambridge, UKNovel Function for FTO in Cell Growth and Translational ControlMartin Heni, Eberhard Karls University Tübingen, GermanyVariation in the Obesity Risk Gene FTO Determines the PostprandialCerebral Processing of Food StimuliRoger D. Cone, University of Michigan, USADevelopmental Control of the Pharmacological Function of theMelanocortin-4 Receptor by MRAP2 ProteinsQingchun Tong, University of Texas Medical School, USADisruption of Glutamate Release from Leptin Receptor-ExpressingNeurons Results in Torpor-Like BehaviorLei Zhang, Garvan Institute of Medical Research, AustraliaGender Specific Role of Neuropeptide FF Receptor 2 in theRegulation of Energy Balance and Glucose Homeostasis

Dissecting CNS Control of Metabolism II *Scott Waddell, University of Oxford, UKScott M. Sternson, HHMI/University of California, San Diego, USANeural Circuits and Motivational Processes Underlying HungerLora K. Heisler, Rowett Institute, University of Aberdeen, UKCNS Integration of Metabolic SignalsVishwa Deep Dixit, Pennington Biomedical Research CenterInflammasomes and AstrogliosisDaniel D. Lam, Stanford University, USAShort Talk: A Dual Enhancer Complex Controls Neuronal PomcExpression and Body Weight

Poster Session 3

THURSDAY, MARCH 21Neurocircuitry and Systemic Control of Metabolism *William F. Colmers, University of Alberta, CanadaLori M. Zeltser, Columbia University, USAPlasticity in Developing Circuits Regulating Energy HomeostasisMartin G. Myers, Jr., University of Michigan, USALeptin Receptors in the Brain: Where Do They Matter?Michael A. Cowley, Monash University, AustraliaLeptin Modulation of DMH Circuits Controlling the SympatheticNervous SystemRoberto Coppari, University of Genève, SwitzerlandMetabolic Actions of Hypothalamic SIRT1Stephanie M. Correa, University of California, San Francisco, USAShort Talk: A Population of Estrogen-Responsive Nkx2-1 Neurons inthe Ventromedial Hypothalamus (VMH) Mediates Sex-Specific Obesityin MiceBarbora Doslikova, University of Alberta, CanadaShort Talk: 5-HT2C Receptor Agonist Anorectic Efficacy Potentiatedby 5-HT1B Receptor Agonist Co-Application; an Effect Mediated viaAugmented Pro-Opiomelanocortin Neuron Activation

Glia Cells and CNS Control of Metabolism *Serge Luquet, Université Paris Diderot, FranceMatthias H. Tschöp, Helmholtz Zentrum München and TechnischeUniversität München, GermanyHypothalamic Inflammatory Processes in Diabetes and ObesityLicio A. Velloso, University of Campinas, BrazilA Role for Hypothalamic Microglia in Obesity and DiabetesDarya Kryzskaya, McGill University, CanadaShort Talk: A Role for Hypothalamic NG2-glia in Energy Homeostasis

Closing Keynote Address *Matthias H. Tschöp, Helmholtz Zentrum München and TechnischeUniversität München, GermanyMichael W. Schwartz, University of Washington, USABrain Mechanisms Governing Glucose Homeostasis: Implications forDiabetes Pathogenesis and Treatment

FRIDAY, MARCH 22Departure

* Session Chair † Invited but not yet accepted Program current as of October 21, 2021. Meal formats are based on meeting venue. For the most up-to-date details, visit https://www.keystonesymposia.org.

KEYSTONE SYMPOSIAon Molecular and Cellular Biology

Neuronal Control of Appetite, Metabolism and Weight (C6)March 17-22, 2013 • Fairmont Banff Springs • Banff, AB, Canada

Scientific Organizers: Tony K.T. Lam and Matthias H. TschöpSponsored by AVEO Oncology

Discounted Abstract & Scholarship Deadline: November 14, 2012 / Late-Breaking Abstract Deadline: December 19, 2012 / Early Registration Deadline: January 17,2013