Keystone Symposia on Molecular and Cellular Biology is a nonprofit organization headquartered in Colorado, USA directed and supported by the scientific community.

Age-related diseases and disabilities, such as cancer, diabetes and neuronal degeneration, pose an ever-increasing social and economic burden worldwide.

Fortunately, the last decades have witnessed dramatic progress in our understanding of the aging process. Genetic studies in particular have helped elucidate some of the molecular pathways that regulate aging and have offered new insights into the treatment of age-related diseases. However, there is still much to be learned, and further progress in addressing the unique challenges of the aging population will require new insights and novel approaches. In order to accelerate the discovery process, this Keystone Symposia meeting will cover essential aspects of the aging processes, including cell signaling pathways, DNA stability, protein homeostasis, stem cells and cellular senescence. Each plenary session will emphasize innovative findings from a variety of models in basic research areas and link them to age-related disease and frailty. The ultimate goal is to provide an opportunity for attendees to communicate and promote an integrated understanding of aging and age-related diseases. The program for this meeting is highly likely to attract a wide variety of investigators, many of whom might not otherwise interact.

Session Topics: > Cell Signaling > Stem Cells and Aging> DNA Damage Response, Telomeres

and Cellular Senescence> Age-Related Neurodegenerative Diseases> Aging and Metabolic Diseases> Aging and Cardiovascular Diseases

Keynote Speaker: David A. Sinclairpresenting on “Sirtuins, Aging and Diseases of Aging”

Abstract & Scholarship Deadline: June 21, 2012Late-Breaking Abstract Deadline: July 25, 2012Early Registration Deadline: August 22, 2012Note: Scholarships are available to students and postdoctoral fellows. Short talk speakers will be selected from abstracts. Early registration saves US$150 on later fee. Information shown is current as of March 29, 2012 but subject to change.

www.keystonesymposia.org/12S2

1.970.262.1230 | 1.800.253.0685 (US & Canada)Keystone Symposia on Molecular and Cellular Biology is a nonprofit organization

headquartered in Colorado, USA directed and supported by the scientific community.

Keystone Symposia is pleased to present

Aging and Diseases of Aging Scientific Organizers: Takashi Kadowaki, Leonard P. Guarente, Judith Campisi and Sean M. Oldham

October 22–27, 2012 | Sheraton Miyako Hotel Tokyo | Tokyo, Japan

TUESDAY, OCTOBER 23

Welcome and Keynote Address David A. Sinclair, Harvard Medical School, USASirtuins, Aging and Diseases of Aging

Cell Signaling I Leonard P. Guarente, Massachusetts Institute of Technology, USAAging and Disease: Connections to SirtuinsHeidi Tissenbaum, University of Massachusetts Medical School, USARegulation of Lifespan by C. elegans FOXO/DAF-16Eisuke Nishida, Kyoto University, JapanJNK/AP-1 Signaling and Longevity in C. elegansLaura Bordone, Genomics Institute of the Novartis Foundation, USASIRT4 Regulates Fatty Acid Oxidation and Mitochondrial GeneExpression in Liver and Muscle Cells

Cell Signaling II Sean M. Oldham, Sanford-Burnham Medical Research Institute, USAThe Role of the TOR Pathway in Obesity and AgingShin-ichiro Imai, Washington University School of Medicine, USAThe Systemic Regulatory Network for Mammalian Aging andLongevity: The Brain, SIRT1, and the NAD WorldYousin Suh, Albert Einstein College of Medicine, USAFunctional Genomics of Human AgingShort Talk Chosen from Abstracts

WEDNESDAY, OCTOBER 24

Stem Cells and Aging Heinrich Jasper, University of Rochester, USAAging of Intestinal Stem Cells in DrosophilaAnne Brunet, Stanford University, USAEpigenetic Regulation of Neural Stem Cell AgingAmy J. Wagers, Harvard University, USATissue Maintenance and Stem CellsThomas A. Rando, Stanford University School of Medicine, USAMuscle Stem Cells and AgingShort Talk(s) Chosen from Abstracts

Cell Signaling III Yo-ichi Nabeshima, Foundation for Biomedical Research andInnovation, Japanalpha-Klotho as a Regulator of Calcium Homeostasis and Aging-LikePhenotypeNoboru Mizushima, Tokyo Medical and Dental University, JapanNutrient Signaling and AutophagyToren Finkel, NHLBI, National Institutes of Health, USAMitochondrial Dysfunction, Oxidative Stress and AutophagyShort Talk Chosen from Abstracts

THURSDAY, OCTOBER 25

DNA Damage Response, Telomeres and Cellular Senescence Judith Campisi, Buck Institute for Research on Aging, USAThe DNA Damage Response, Inflammation and AgingManuel Serrano, Spanish National Cancer Center (CNIO), SpainTumour Suppressors at the Interface between Cancer and AgingFuyuki Ishikawa, Kyoto University, JapanTelomere and Cellular SenescenceCynthia T. McMurray, Lawrence Berkeley National Laboratory, USAThe Role of DNA Damage Response Signals in NeurodegenerativeDiseasesShort Talk(s) Chosen from Abstracts

Age-Related Neurodegenerative Diseases Ana Maria Cuervo, Albert Einstein College of Medicine, USARole of Autophagy in Neurodegenerative DiseasesAndrew G. Dillin, The Salk Institute for Biological Studies, USAAging as an Event of Proteostasis CollapseDale E. Bredesen, Buck Institute for Research on Aging, USARole of Cell Death Signaling in Alzheimer's DiseaseShort Talk Chosen from Abstracts

FRIDAY, OCTOBER 26

Aging and Metabolic Diseases Takashi Kadowaki, University of Tokyo, JapanThe Role of Adiponectin and Adiponectin Receptors in Type 2Diabetes and Metabolic DiseasesJuleen R. Zierath, Karolinska Institutet, SwedenGene/Environment Influence in Skeletal Muscle Insulin Sensitivity inType 2 Diabetes PatientsJohan Auwerx, École Polytechnique Fédérale de Lausanne (EPFL),SwitzerlandTitle to be DeterminedEric M. Verdin, University of California, San Francisco, USASIRT3 Regulates Mitochondrial Protein Acetylation and IntermediaryMetabolismShort Talk(s) Chosen from Abstracts

Aging and Cardiovascular Diseases Edward G. Lakatta, NIH National Institute on Aging, Laboratory ofCardiovascular Science, USAThe Stress of Aging Viewed from the Arterial WallRolf Bodmer, Sanford-Burnham Medical Research Institute, USACardiac Aging in DrosophilaHiroshi Itoh, Keio University School of Medicine, JapanMetabolic Syndrome and Vascular AgingShort Talk Chosen from Abstracts

Program current as of April 5, 2012. Program subject to change. For the most up-to-date details, visit www.keystonesymposia.org/13S2.* Session Chair  † Invited but not yet accepted

KEYSTONE SYMPOSIAon Molecular and Cellular Biology

Aging and Diseases of Aging (S2)October 22-27, 2012 •  Sheraton Miyako Hotel Tokyo •  Tokyo, Japan •  Japan

Scientific Organizers: Takashi Kadowaki, Leonard P. Guarente, Judith Campisi and Sean M. OldhamAbstract & Scholarship Deadline: June 21, 2012 / Late-Breaking Abstract Deadline: July 25, 2012 / Early Registration Deadline: August 22, 2012