2014 B3 Save the Date - Keystone Symposia

Discounted Abstract Deadline: October 17, 2013Student/Postdoc Scholarship Application Deadline: October 17, 2013Abstract Deadline: November 20, 2013Discounted Registration Deadline: December 16, 2013

Save the Date for the 2014 Keystone Symposia meeting on:

Omics Meets Cell Biology: Applications to Human Health and DiseaseFebruary 18–23, 2014 Sagebrush Inn and Conference Center, Taos, New Mexico, USAScientific Organizers: Anne-Claude Gingras, Igor Stagljar and A.J. Marian Walhout

The conference will: • Explore the current status of the interface between “omics” and cell biology in general, and in selected areas

of research including: how “omics” tools are used to understand genotype-phenotype relationships; how they can assist in the process of drug discovery; and how they contribute to providing an integrated view of cellular signaling, gene expression and metabolic networks;

• Bridge classical cell biology, biochemistry/genetics and systematic (“omics”) approaches;

• Foster thought-provoking discussions around data quality, data analysis, data sharing and data integration by inviting interactions between experimental biologists and technologists and computational experts.

For more information and to view the full program, visit www.keystonesymposia.org/14B3

see overleaf for full program

Omics Meets Cell Biology: Applications to Human Health and DiseaseMeeting Program

TUESDAY, FEBRUARY 18, 2014Arrival and Registration

WEDNESDAY, FEBRUARY 19, 2014Keynote Address Brenda J. Andrews, University of Toronto, Canada Integrating Omics and Cell Biology: Applications to Global Protein Localization and Flux Maps in YeastProteomics Technologies: Applications to Disease Matthias Selbach, Max Delbrück Center for Molecular Medicine, Germany From Protein-Protein Interactions to Disease Phenotypes Anne-Claude Gingras, Samuel Lunenfeld Research Institute, Canada Signaling Interactome Dynamics in Health and Disease Ileana M. Cristea, Princeton University, USA Proteomics Meets Virology Short Talk(s) Chosen from AbstractsPanel: Industry Options in “Omics”: From Technology Development to Applications Omics Meets Genetics and Gene Expression Heng Zhu, Johns Hopkins University School of Medicine, USA Global Analysis of DNA Methylation-Dependent Transcription Factor-Binding Activity Michael Snyder, Stanford University School of Medicine, USA Extensive Dynamic Changes in Omics Profiles during Normal and Disease States Frank C.P. Holstege, University Medical Center, Utrecht, Netherlands Validation of a Gene Expression Signature for Assessment of Lymph Node Metastasis in Oral Squamous Cell Carcinoma Short Talk Chosen from AbstractsPoster Session 1

THURSDAY, FEBRUARY 20, 2014From Genotype and Phenotype Charlie M. Boone, University of Toronto, Canada The Genetic Landscape of the Cell Yoshi Ohya, University of Tokyo, Japan Chemical Genetic Approaches to Elucidate Complex Cellular Processes Giulio Superti-Furga, CeMM Center for Molecular Medicine of the Austrian Academy of Sciences, Austria Charting and Challenging the Molecular Machinery of Human Cells Short Talks Chosen from Abstracts Panel: Academic Careers in “Omics”: Starting Up a Successful Research Program Omics Meets Drug Discovery Stefan Knapp, University of Oxford, UK Using Structural Proteomics as a Tool for Drug Discovery Domagoj Vucic, Genentech, Inc., USA Targeting Ubiquitin Ligases in Cancer and Inflammation Gerard Drewes, Cellzome – a GSK Company, Germany Chemical Proteomics of Enzyme Families Short Talk Chosen from AbstractsPoster Session 2

FRIDAY, FEBRUARY 21, 2014Computational Analysis of Systems Biology Peer Bork, European Molecular Biology Laboratory, Germany Systemic Analysis of the Human Gut: Learning from Bugs and Drugs Nuno Bandeira, University of California, San Diego, USA Toward Extensive Characterization of all Variation in Proteomics and Beyond Olga G. Troyanskaya, Princeton University, USA From Functional Genomics Studies to the Cell-Lineage Specific View of Human Disease Trey Ideker, University of California, San Diego, USA Mapping the Genetic Networks of Cancer Short Talk(s) Chosen from AbstractsPanel: Publishing High Impact “Omics” Papers An Integrated View of Cellular Signaling Tony Pawson, Samuel Lunenfeld Research Institute, Canada Signaling Networks in Cell Fate Determination Walter Kolch, University College Dublin, Ireland Molecular Computing: How Protein Interaction Networks Coordinate Cell Fate Decisions Igor Stagljar, University of Toronto, Canada Protein Interaction Networks Regulating Cell Signaling in Human Health and Disease Short Talk Chosen from AbstractsPoster Session 3 SATURDAY, FEBRUARY 22, 2014Global Analysis of Metabolic and Lipidomics Networks Markus Ralser, University of Cambridge, UK Genetic Basis of Stability and Flexibility of Metabolic Networks Markus R. Wenk, National University of Singapore, Singapore Natural Variation of Blood Lipids in Healthy Human Individuals with Different Ethnic Backgrounds A.J. Marian Walhout, University of Massachusetts Medical School, USA Integrative Network Biology in the Nematode C. elegans Anne-Claude Gavin, European Molecular Biology Laboratory (EMBL), Germany Expending the Interaction Space: Protein-Metabolite Networks Short Talk(s) Chosen from AbstractsOmics and Neurodegenerative Disorders Paola Picotti, ETH Zurich, Switzerland Probing Generic and Specific Responses to Intracellular Protein Aggregation Erich E. Wanker, Max Delbrueck Center for Molecular Medicine, Germany From Protein Interaction Networks to Neurodegenerative Disease Mechanisms Tony Schapira, University College London, France The Intersection of Biochemistry and Genomics in Parkinson’s Disease PathogenesisClosing Address Rudolf H. Aebersold, Institute of Molecular Systems Biology, ETH Zurich, Switzerland Network Driven Protein Biomarker Discovery and Validation

Information is current as of June 18, 2013 but subject to possible change. Please visit www.keystonesymposia.org/14B3 for the most up-to-date program information.

TUESDAY, FEBRUARY 18Arrival and Registration

WEDNESDAY, FEBRUARY 19Keynote Address *Igor Stagljar, University of Toronto, CanadaBrenda J. Andrews, University of Toronto, CanadaExploring Biological Pathways and Networks Using Yeast FunctionalGenomics

Proteomics Technologies: Applications to Disease *Igor Stagljar, University of Toronto, CanadaAnne-Claude Gingras, Lunenfeld-Tanenbaum Research Institute,CanadaSignaling Interactome Dynamics in Health and DiseaseIleana M. Cristea, Princeton University, USAProteomics Meets VirologyMikko Taipale, University of Toronto, CanadaShort Talk: A Quantitative Chaperone Interaction Network Reveals theArchitecture of Cellular Protein Homeostasis PathwaysMartin Beck, European Molecular Biology Laboratory, GermanyShort Talk: Cell-Type Specific Nuclear Pores: How the NuclearTransport System Is Fine-Tuned toward Context-Specific NeedsBernd Wollscheid, ETH Zürich, SwitzerlandDecoding Ligand Receptor Interactions

Panel: Industry Options in "Omics": From TechnologyDevelopment to Applications *Igor Stagljar, University of Toronto, CanadaGiulio Superti-Furga, Research Center for Molecular Medicine of theAustrian Academy of Sciences, AustriaDomagoj Vucic, Genentech, Inc., USASabine Bahn, University of Cambridge, UK

Omics Meets Genetics and Gene Expression *A.J. Marian Walhout, University of Massachusetts Medical School,USAHeng Zhu, Johns Hopkins University School of Medicine, USADNA Methylation Presents Distinct Binding Sites for HumanTranscription FactorsMichael P. Snyder, Stanford University School of Medicine, USAPersonalized Medicine: Personal Omics Profiling of Healthy andDisease StatesMarko Jovanovic, Max Planck Institute of Brain Research, GermanyShort Talk: Quantitating the Mammalian Transcriptome and ProteomeRelationship in a Dynamic Response to Pathogen SignalMichael J. Lee, University of Massachusetts Medical School, USADynamic Rewiring of Apoptotic Signaling: A Network-Centric Study ofCombination Therapies for Triple-Negative Breast Cancer

Poster Session 1

THURSDAY, FEBRUARY 20

From Genotype and Phenotype *Markus Ralser, Francis Crick Institute, UKCharlie M. Boone, University of Toronto, CanadaThe Genetic Landscape of a CellAndrew Fraser, University of Toronto, CanadaA Whole Can of Worms: The Effect of Genome Evolution onLoss-of-Function Phenotypes in Different NematodesYoshikazu Ohya, University of Tokyo, JapanHigh-Resolution Phenotyping to Elucidate Essential Complex CellularProcessesLouise Evans, Institute of Cancer Research, UKShort Talk: High-Content Combinatorial RNAi Screens RevealLarge-Scale Signaling Networks Regulating CytokinesisGiulio Superti-Furga, Research Center for Molecular Medicine of theAustrian Academy of Sciences, AustriaMolecular Networks: Drug Action and Genome-Informed Medicine

Panel: Academic Careers in "Omics": Starting Up a SuccessfulResearch Program *Anne-Claude Gingras, Lunenfeld-Tanenbaum Research Institute,Canada

Omics Meets Drug Discovery *Giulio Superti-Furga, Research Center for Molecular Medicine ofthe Austrian Academy of Sciences, AustriaStefan Knapp, University of Oxford, UKUsing Structural (Chemo)-Proteomics as a Tool for Target DiscoveryDomagoj Vucic, Genentech, Inc., USATargeting Ubiquitin Ligases in Cancer and InflammationGerard Drewes, GlaxoSmithKline, GermanyCharting Drug Target Complexes with Small MoleculesIrma Lemmens, Ghent University/VIB, BelgiumShort Talk: MAPPIT and KISS, Two Complementary Methods toDetect Protein-Protein and Protein-Small Molecule Interactions inLiving Mammalian Cells

Poster Session 2

FRIDAY, FEBRUARY 21Computational Analysis of Systems Biology *Anne-Claude Gavin, European Molecular Biology Laboratory,GermanyTrey Ideker, University of California, San Diego, USAMapping the Genetic Networks of CancerNuno Bandeira, University of California, San Diego, USAThe Transformative Role of Data Repositories in High ThroughputProteomicsOlga G. Troyanskaya, Princeton University, USAFrom Functional Genomics Studies to the Cell-Lineage Specific Viewof Human DiseaseJonathan H. Young, Texas Tech University Health Sciences Center,USAShort Talk: Novel Drug Targets for Non-Small Cell Lung Cancer fromComputational Analysis of a Whole Genome RNAi Screen

* Session Chair † Invited but not yet accepted Program current as of November 23, 2021. Meal formats are based on meeting venue. For the most up-to-date details, visit https://www.keystonesymposia.org.

KEYSTONE SYMPOSIAon Molecular and Cellular Biology

Omics Meets Cell Biology: Applications to Human Health and Disease (B3)February 18-23, 2014 • Sagebrush Inn & Suites • Taos, NM, USA

Scientific Organizers: Anne-Claude Gingras, Igor Stagljar and A.J. Marian WalhoutSponsored by Biogen Idec and Novo Nordisk A/S. Supported by an educational donation provided by Amgen.

Discounted Abstract & Scholarship Deadline: October 17, 2013 / Abstract Deadline: November 20, 2013 / Discounted Registration Deadline: December 16, 2013

Murat Tasan, University of Toronto, CanadaShort Talk: Causal Networks in Genome-Wide Association StudiesA.J. Marian Walhout, University of Massachusetts MedicalSchool, USANutritional Regulatory Networks

Panel: Publishing High Impact "Omics" Papers *A.J. Marian Walhout, University of Massachusetts MedicalSchool, USA

An Integrated View of Cellular Signaling *Ileana M. Cristea, Princeton University, USAShohei Koide, New York University Langone Health, USAControlling Signaling Networks by Protein DesignWalter Kolch, University College Dublin, IrelandSignalling Networks Regulated by Compartmentalised RasSignallingAnne E. White, Harvard Medical School, USAShort Talk: Quantitative Analysis of the Hippo Pathway in Lowand High-Density CellsIgor Stagljar, University of Toronto, CanadaDynamic Interactomes of “Druggable” Membrane Proteins: Rolesin Human Health and Disease

Poster Session 3

SATURDAY, FEBRUARY 22Global Analysis of Metabolic and Lipidomics Networks Markus Ralser, Francis Crick Institute, UKEMBO Young Investigator Lecture: Genetic Basis of Stability andFlexibility of Metabolic NetworksMarkus R. Wenk, National University of Singapore, SingaporeNatural Variation of Lipidomes Anne-Claude Gavin, European Molecular Biology Laboratory,GermanyExpending the Interaction Space: Protein-Lipid NetworksPeer Bork, European Molecular Biology Laboratory, GermanyMetagenomic Analysis of the Human Gut Microbiome: Variation,Stratification and Associations to Disease

Omics and Neurodegenerative Disorders *Bernd Wollscheid, ETH Zürich, SwitzerlandSabine Bahn, University of Cambridge, UKSerum Biomarkers for Psychiatric DisordersErich E. Wanker, Max Delbrueck Center for Molecular Medicine,GermanyFrom Protein Interaction Networks to Neurodegenerative DiseaseMechanismsEric J. Bennett, University of California, San Diego, USAUsing the Ubiquitin-Modified Proteome to Evaluate ProteinHomeostasis Function

Closing Address *Anne-Claude Gingras, Lunenfeld-Tanenbaum ResearchInstitute, CanadaRudolf H. Aebersold, Institute of Molecular Systems Biology,ETH Zürich, SwitzerlandNetwork Driven Protein Biomarker Discovery and Validation

SUNDAY, FEBRUARY 23Departure











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2014 B3 Save the Date - Keystone Symposia