An “Innovative Key Moisturising Factor”

dispersed in a Multi-lamellar arrangement

that represents the new basis for

Bio-functional Cosmetics

PHYSICO-CHEMICAL AND MICROBIOLOGICAL PARAMETERS

Appearance at 20°C: Opalescent fluidColour: Straw yellowOdour: Mild CharacteristicpH: 6,5 – 7,5 ( Potenziometric)Dry Residue: 38 - 42%Total Nitrogen: 4,5 – 5,5%Total microbial count: less than 100 CFU/g (Agar count)

DOSAGE:2-20%

STORAGE CONDITIONSStore in well closed containers, in a cool, dry place, away from the reach of light and humidity.

Kemiderm Microsomic KMF

INCI NAME (UE) Aqua, Potassium Lauroyl Wheat Aminoacids , Ethylexyl Palmitate ,Phospholipides , Urea , Glucose, Sodium PCA , Sorbitol , Fructose, Hydrolyzed Wheat Protein,Sodium Glutamate, Glycine , Lysine , Malic Acid, Citric Acid , Glycolic Acid, Tartaric Acid,Lactic Acid, Sodium Hydroxide , Potassium Hydroxide.

10 Volunteers were selected, male and female, aged between 18 and 70 years. On the rightforearm a cream containing 5% of Kemiderm Microsomic KMF was applied: the samecream, containing only water (placebo), was applied to the left forearm. Measurements(electric capacity) were carried out after 1 hour from the time of application, and at intervals(from time 0 after 1 hour, twice a day from 2 to 7 days).

SKIN MOISTURISING EFFICACY TESTS(Skin Diagnostic SD 27)

Med

ium

moi

stur

isin

g fa

ctor

Moisturising increase with andwithout Kemiderm Microsomic KMF

after 1 hour

Placebo

KemidermMicrosomicKMF

Med

ium

moi

stur

isin

g fa

ctor

Moisturising increase with andwithout Kemiderm Microsomic KMF

after 1 week

Placebo

KemidermMicrosomicKMF

KEMIDERMMICROSOMIC KMF

The New Generation of Moisturizing Factors

Head Office and Production:Via G. Pastore,1

25082 Botticino Sera (BS) ITALIATel: +39.030.2693532Fax: +39.030.2193581

e-mail: kalichem@kalichem.itwww.kalichem.it

Head Office and Production:Via G. Pastore,1

25082 Botticino Sera (BS) ITALIATel: +39.030.2693532Fax: +39.030.2193581

e-mail: kalichem@kalichem.itwww.kalichem.it

KEMIDERM MICROSOMIC KMF: TECHNOLOGY

Kemiderm Microsomic KMF is an innovative cosmetic structure. It is made of a complexof moisturising factors dispersed in a multi-lamellar arrangement. The biological activity ofthis structure enhances the basic moisturising properties.

KEMIDERM MICROSOMIC KMF: COMPOSITION

Kemiderm Microsomic KMF is produced by means of an innovative technology (HPM-High Pressure Micronisation) based on a mixture of lipids, phospholipids and Kalichem’sKemiderm NMF V (a mixture of sugars, hydroxyl acids, amino-acids, Sodium PCA, etc.),balanced in order to replicate the natural composition of well moisturised skin.All of the components of NMF are of vegetal origin. Phospolipids on the other hand, comefrom Soy.

Kemiderm Microsomic KMF is based

on two key factors: firstly, a vegetal based,

yet thouroughly balanced, NMF.

Secondly, a system of vegetal

phospholipids, lipoaminoacids and

lipids, arranged in a blend of microsomic

and microemulsion structures, composed

of dermo-like substances belonging to

skin physiology. The combination of

these structures makes Kemiderm

Microsomic KMF an ideal vector for

the cutaneous biochemical transport, as

well as supplying the skin with

structuring lipids and water-coordinating

molecules.

Kemiderm Microsomic KMF is a new

generation of moisturising factors. Its

action is not only performed by

supplying the skin with water

coordinating agents, but mainly by

reinforcing and rebalancing water-

organized lipids. This occurs by the

provision of lipid by-layers, the same

physiologic mechanism which is the key

responsibility, in healthy skin layers, of

the homeostasis of moisture balance.

The formulator is therefore provided

with a new tool for the reintegration of

skin lipids, without any greasiness. The

lipid molecules are hidden within the

phospholipids structures, which makes

them readily available for maximum

efficacy.

Nano-liposome: multi-lamellar layerof phospho-lipids enclosing a wateryphase (Kemiderm NMF V)

NMF

The production of nano-liposomes by the cells of the epidermis is a natural process.Liposomes are produced by Golgi-apparatus of the cells which make up the granular layer,they are then expelled, after which they rise to the stratum lucidum which separates the livingcells from the dead cells (horny layer).In the stratum lucidum, liposomes are destroyed by natural enzymes, thus releasing theircontent (fatty acids, lipids , ceramides) and forming the cementing layer, responsible for theregulation of TWEL (trans – epidermal water loss).Through the use of Kemiderm Microsomic KMF it is possible to recreate this mechanismin an opposite manner: it is possible to supply from the outside moisturising ingredients andlipids that are available now in a bio-compatible form.Further to this, these lipids and moisturising ingredients are protected from the action of theenzymes’ flora which may otherwise modify their usefulness.

Kemiderm Microsomic KMF can be used in any formula in which an innovative, completeand highly efficient moisturising functional ingredient is required.Kemiderm Microsomic KMF is able to provide the skin with both the required moisturisingingredients (of vegetal origin and naturally balanced), as well as with the lipids necessary forreinforcing and rebalancing the lipid layer – therefore playing an important role in themaintenance of well moisturised skin.In addition to this, Kemiderm Microsomic KMF is able to supply lipids in a non-greasy,bio-compatible form, thereby allowing the formulation of a finished product with a light,dry, texture.Kemiderm Microsomic KMF is recommended for use in all instances in which an improvementof the natural moisture level of the skin is required, as well as when the maintenance of theskin’s natural hydration is required in order to prepare the skin for acceptance of otherfunctional ingredients.Kemiderm Microsomic KMF is recommended for use in creams, body lotions, body milksand serums, as well as in foundation creams, in which it is most advantageous in its abilityto block excessive dehydration of the skin (often caused by the pigments within foundationformulae).

KEMIDERM MICROSOMIC KMF: ACTIVITY

KEMIDERM MICROSOMIC KMF: APPLICATIONS

Since an excess of phospholipids is employed with respect tothe quantity of lipids utilised, we are able to obtain at the sametime a nano-emulsion and a nano-liposome solution.

Granularlayer

Stratumlucidum

Horny

Basallayer

Epidermis

Dermis

Adipose tissue

Muscle

Hairfollicle

Sweatgland

Head Office and Production:Via G. Pastore,1

25082 Botticino Sera (BS) ITALIATel: +39.030.2693532Fax: +39.030.2193581

e-mail: kalichem@kalichem.itwww.kalichem.it

Head Office and Production:Via G. Pastore,1

25082 Botticino Sera (BS) ITALIATel: +39.030.2693532Fax: +39.030.2193581

e-mail: kalichem@kalichem.itwww.kalichem.it