Jeffrey Keith Smith, M - UNC Health · 5656 Kelley, Department of Radiology Houston, Texas 77026 (713) 636-5440. Hermann Hospital (moonlighting) The University of Texas Health Science

CURRICULUM VITAE Jeffrey Keith Smith, M.D., Ph.D.

PERSONAL INFORMATION:

PRESENT POSITIONS: Professor of Radiology (Tenured) Clinical Professor, Neurosurgery (Fixed Term) Vice-Chair of Diagnostic Services Director, Clinical Research Director, Faculty Development for Clinical Faculty Department of Radiology, University of North Carolina at Chapel Hill School of Medicine

WORK ADDRESS: Department of Radiology, University of North Carolina at Chapel Hill School of Medicine

Neuroradiology Division 3327 Old Infirmary Building, CB# 7510 Chapel Hill, NC 27599-7510

ADDRESS OF CLINICAL UNC Hospitals INVESTIGATION: The University of North Carolina at Chapel Hill

101 Manning Drive Chapel Hill, NC 27599-7600

MEDICAL LICENSES: North Carolina: Texas (inactive) Louisiana (inactive)

HUMAN SUBJECTS NIH Office of Human Subjects Research Training RESEARCH TRAINING: course September 21, 2000, Serial #: 969550654 ORCID ID: 0000-0001-7588-3520 SCOPUS AUTHOR ID: 35554084300

REACH-NC: jeffrey-keith-smith

http://orcid.org/0000-0001-7588-3520

http://orcid.org/0000-0001-7588-3520

http://www.scopus.com/authid/detail.uri?authorId=35554084300

https://uncch.pure.elsevier.com/en/persons/jeffrey-keith-smith/publications/

J. Keith Smith M.D., Ph.D.

Updated on August 9, 2016 2/41

EDUCATION:

BOARD CERTIFICATION: The American Board of Radiology Diagnostic Radiology, June 15, 1993 Neuroradiology, November 3, 1997 Neuroradiology, recertification June 14, 2007 Neuroradiology, MOC active FELLOWSHIP TRAINING: Neuroradiology

The University of North Carolina at Chapel Hill July 1, 1993 to June 30, 1995 RESIDENCY TRAINING: Diagnostic Radiology

The University of Texas Health Science Center, Houston, Texas, July 1, 1989 to June 30,1993 GRADUATE SCHOOL: Louisiana State University Medical School, Shreveport, LA, Department of Physiology: Ph.D. June 30, 1989 MEDICAL SCHOOL: Louisiana State University Medical School Shreveport, LA: M.D. May 30, 1987 COLLEGE: Louisiana State University-Baton Rouge, Louisiana: Major in Biochemistry, Minor in Computer Science September 1, 1980 to May 30, 1983

PROFESSIONAL EXPERIENCE:

7/1/15-Present: Vice-Chair of Diagnostic Services,

Director, Clinical Research, Director, Faculty Development for Clinical Faculty

Department of Radiology, University of North Carolina at Chapel Hill School of Medicine

9/1/11-Present: Professor of Radiology (with Tenure) Department of Radiology, University of North Carolina

at Chapel Hill School of Medicine 1/1/13-Present: Professor of Neurosurgery (fixed term, non salaried) Department of Radiology, University of North Carolina

at Chapel Hill School of Medicine 4/1/11-7/1/15: Vice-Chair of Clinical Research within the Department of Radiology 1/1/07-4/1/11: Residency Program Director, Diagnostic Radiology

Department of Radiology, University of North Carolina at Chapel Hill School of Medicine



9/1/11-1/1/14: Clinical Associate Director, and Quality and Safety Officer

UNC Biomedical Research Imaging Center (BRIC) 11/1/04-8/31/11: Associate Professor of Radiology (with Tenure) Department of Radiology, University of North Carolina

at Chapel Hill School of Medicine 7/1/99-10/31/04: Assistant Professor of Radiology Department of Radiology, University of North Carolina

at Chapel Hill School of Medicine

7/1/96-6/30/99: Clinical Assistant Professor of Radiology Department of Radiology, University of North Carolina

at Chapel Hill School of Medicine

7/1/95-1/11/98: Mid-Carolina Radiology Associates, P.A. 115 S. Gulf Street, P.O. Box 1007 Sanford, North Carolina 27330, (919) 774-2360 7/1/91-6/30/93: Lyndon B. Johnson General Hospital (moonlighting)

5656 Kelley, Department of Radiology Houston, Texas 77026 (713) 636-5440 Hermann Hospital (moonlighting) The University of Texas Health Science Center 6431 Fannin, Room 2.132 MSMB Houston, Texas 77030 (713) 792-5230 Department of Radiology (moonlighting) Pasadena General Hospital, P.O. Box 2002 Pasadena, Texas 77501 (713) 473-1771 Department of Radiology (moonlighting) Southmore Hospital, 901 E. Curtis Pasadena, Texas 77502 (713) 475-5865



HONORS AND AWARDS: Faculty:

AUR-AGFA Radiology Management Program San Antonio, TX, March 20-21, 2012. There is a competitive application for this leadership development course. Fellow, UNC School of Medicine Academy of Educators elected 2011-2016. Membership is an honor and recognition of teaching excellence and dedication to the education mission of the School of Medicine. UNC School of Medicine Mid Career Leadership Initiative 2010, University of North Carolina at Chapel Hill School of Medicine UNC School of Medicine Teaching Scholar 2007-2008, University of North Carolina at Chapel Hill School of Medicine

Fellowship: Cum laude citation at the annual meeting of the Radiological Society of North America, November 27-December 2, 1994 Chicago, Illinois. For: SMITH JK, Castillo MC, Merten DF. Imaging of the CNS in child abuse: Computer-aided program.

Cum Laude award. SCATLIFF JH, CASTILLO MC, GREEN JJ, SUZUKI K, CHANCELLOR K, SMITH JK. Postmortem MR imaging of lobar infarction with pathologic correlation. Radiological Society of North America Meeting, 1994

Residency: RSNA/AUR/ARRS “Introduction to Research” program participant Graduate School: Proctor and Gamble Professional Opportunity Award, March, 1989 Graduate student representative to the LSUMC executive council Medical School: AOA - Selected as a Junior Student Class Rank 1 out of 88 Bernstein Scholarship - Based on Academic Achievement LSUMC School Yearbook Editor 1985 and 1986 Editions

College: PHI KAPPA PHI Honor Society Dean's List - Overall GPA 4.0/4.0 National Merit Scholarship Recipient LSU Alumni Federation Scholarship Recipient Circle K Service Organization Member LSU Yearbook Photographer 1981, 1982, and 1983 Editions



BIBLIOGRAPHY: Summary:

I would like to emphasize that due to my commitment to mentoring fellows, residents, and students, a substantial number of my publications have a trainee as 1st author, while I was 2nd or corresponding author. These are tabulated below as “2nd /Correspond”, and I have underlined the trainee names in citations.

Book Chapters Refereed Articles Invited Articles

1st All 1st 2nd/Correspond Senior All 1st All Professor (2011-present) 1 1 3 14 Associate (2004-2011) 5 6 1 9 8 43 2 4 Assistant (1998-2003) 3 3 4 5 3 21 1 1 Career (1988-present) 9 11 15 16 15 104 3 5

Google Scholar Citation Report (compiled April, 2016):

Results found: 147

Sum of the Times Cited: 5819 Average Citations per Item: 40

h-index: 41 i10-index: 76

(Graph shows citations in each year)

Contributions to Text Books:

1. SMITH JK, ARMAO D, CASTILLO M. Chapter 2. Imaging of Brain Trauma In: Harris & Harris’ Radiology of Emergency Medicine, 5th edition edited by Thomas L. Pope Jr., MD, FACR. Lippincott Williams & Wilkins, Philadelphia, (2013) pp 13-32

2. SMITH JK. Inflammation of the Spinal Cord In: Imaging of the Spine, Expert Radiology Series, Expert Consult. Editors: Thomas P. Naidich, MD, Mauricio Castillo, MD, Soonmee Cha, MD, Charles Raybaud, MD, James G. Smirniotopoulos, MD, Spyros Kollias, MD, and George Kleinman, MD. Elsevier – Saunders, Philadelphia, Pennsylvania, (2010) pp 463-476

3. SMITH JK Congenital Spinal Abnormalities. In: Neuroradiology (Third Series) ACR

Test and Syllabus. H Cohen, M Castillo, JG Smirniotopolous, DB Price, Editors; SF Falcone, MB Fukui, SK Mukherji, ZJ Rumboldt, JK Smith, Co-authors. American College of Radiology, Reston, Virginia (2006) pp 217-230

4. SMITH JK Intramedullary Spinal Masses. In: In: Neuroradiology (Third Series) ACR

Test and Syllabus. H Cohen, M Castillo, JG Smirniotopolous, DB Price, Editors; SF Falcone, MB Fukui, SK Mukherji, ZJ Rumboldt, JK Smith, Co-authors. American College of Radiology, Reston, Virginia (2006) pp 201-216



5. SMITH JK Vertebral Body Tumors. In: Neuroradiology (Third Series) ACR Test and Syllabus. H Cohen, M Castillo, JG Smirniotopolous, DB Price, Editors; SF Falcone, MB Fukui, SK Mukherji, ZJ Rumboldt, JK Smith, Co-authors. American College of Radiology, Reston, Virginia (2006) pp 191-200

6. SMITH JK Spinal Infections. In: Neuroradiology (Third Series) ACR Test and Syllabus.

H Cohen, M Castillo, JG Smirniotopolous, DB Price, Editors; SF Falcone, MB Fukui, SK Mukherji, ZJ Rumboldt, JK Smith, Co-authors. American College of Radiology, Reston, Virginia (2006) pp 181-190

7. RUMBOLDT Z, CASTILLO M, SMITH JK. The spine. In: Lee JKT, Sagel SS, Stanley

RJ, Heiken JP (Eds). Computed Body Tomography with MRI Correlation. 4th Ed, Lippincott Williams & Wilkins, Philadelphia, (2006), pp 1661-1726

8. SMITH JK, CASTILLO M, KWOCK L. Magnetic resonance spectroscopy of brain

tumors. Magn Reson Imaging Clin N Am, Saunders, Castillo M, ed, WB Saunders, Philadelphia, Vol 11 (3), 2003, pp 415-430

9. SMITH JK, CASTILLO M Spinal imaging: New sequences for spinal MR imging.

Basic concepts. In: Spine Imaging. State of the Art Reviews. M Castillo, Editor, Hanley and Belfus, Inc. Philadelphia. 2001, pp 1-16

10. SMITH JK, CASTILLO M. Current imaging of trauma to the spine and spinal cord. In:

Spine Imaging. State of the Art Reviews. M Castillo, Editor, Hanley and Belfus, Inc. Philadelphia. 2001; pp 79-92

11. CASTILLO M, SMITH JK, MUKHERJI S. Imaging of the spine. In: Computed

Tomography with MRI Correlation. 3rd E: Lee, JKT, SS Sager, RJ Stanley, JP Heiken (Eds). d, Lippincott Williams & Wilkins, Philadelphia, 1997

Articles Published in Refereed Journals: (underlined authors are students or trainees)

1. ARMAO DM, HARTMAN T, SHEA CM, SAMS C, CAREY T, FORDHAM L, IVANOVIC M, SMITH JK. A Toolkit for Pediatric CT Dose Reduction in Community Hospitals JACR, The Journal of the American College of Radiology (In Press, JACR-D-16-00103R1, 16 pages, 2016)

2. ARMAO DM, SMITH JK, SEMELKA RC. Debriefing the Brief: It is Time for the Provision of Informed Consent before Pediatric CT. Radiology. 2015 May;275(2):326-30. doi: 10.1148/radiol.2015142860 PMID: 25906300

3. ALCAUTER S, LIN W, SMITH JK, SHORT S, GOLDMAN B, REZNICK J, GILMORE JH, AND GAO W Frequency of Spontaneous BOLD Signal Shifts during Infancy and Correlates with Cognitive Performance Developmental Cognitive Neuroscience 2015 Apr;12:40-50. [Epub 2014 Nov 4] PMID: 25459875 PMCID: PMC4830279



4. ANDERS C, DEAL AM, ABRAMSON V, LIU MC, STORNIOLO AM, CARPENTER JT, PUHALLA S, NANDA R, MELHEM-BERTRANDT A, LIN NU, KELLY MARCOM P, VAN POZNAK C, STEARNS V, MELISKO M, SMITH JK, KARGINOVA O, PARKER J, BERG J, WINER EP, PETERMAN A, PRAT A, PEROU CM, WOLFF AC, CAREY LA. TBCRC 018: phase II study of iniparib in combination with irinotecan to treat progressive triple negative breast cancer brain metastases. Breast Cancer Res Treat. 2014 Aug;146(3):557-66. [Epub ahead of print 2014 Jul 8] (DOI) 10.1007/s10549-014-3039-y] PMID: 25001612, PMC4112043

5. GAO W, ELTON A, ZHU H, ALCAUTER S, SMITH JK, GILMORE JH, LIN W. Inter-subject Variability of and Genetic Effects on the Brain's Functional Connectivity During Infancy. Journal of Neuroscience 08/2014; 34(34):11288-96 PMID: 25143609, PMC4138339

6. GAO W, ALCAUTER S, ELTON A, HERNANDEZ-CASTILLO CR, SMITH JK, RAMIREZ J, LIN W. Functional Network Development During the First Year: Relative Sequence and Socioeconomic Correlations. Cereb Cortex. 2015 Sep;25(9):2919-28. doi: 10.1093/cercor/bhu088. [Epub ahead of print 2014 May 8] PMID: 24812084, PMC4537436

7. ALCAUTER S, LIN W, SMITH JK, SHORT S, GOLDMAN B, REZNICK J, GILMORE JH, AND GAO W. Development of Thalamocortical Connectivity during Infancy and Its Cognitive Correlations. Journal of Neuroscience July 2, 2014 34(27):9067–9075 PMID: 24990927, PMC4078084

8. KNICKMEYER RC, MELTZER-BRODY S, WOOLSON S, HAMER RM, SMITH JK, LURY K, GILMORE JH, Rate of Chiari I Malformation in Children of Mothers with Depression with and without Prenatal SSRI Exposure. Neuropsychopharmacology. 2014 Oct;39(11):2611-21. doi: 10.1038/npp.2014.114. [Epub 2014 May 20] (article selected for press release by UNC school of medicine and Neuropsychopharmacology Journal) PMID: 24837031, PMC4207341

9. ARMAO D, SMITH JK. Overuse of computed tomography and the onslaught of incidental findings. N C Med J. 2014 Mar-Apr;75(2):127. PMID: 24663136

10. ARMAO D, SMITH JK. The health risks of ionizing radiation from computed tomography. N C Med J. 2014 Mar-Apr;75(2):126, 128-31. PMID: 24663135

11. GAO W, ALCAUTER S, SMITH JK, GILMORE JH, LIN W. Development of human brain cortical network architecture during infancy. Brain Struct Funct. 2015 Mar;220(2):1173-86 [Epub ahead of print 2014 Jan 28] PMID: 24469153, PMC3105376

12. ALCAUTER S, LIN W, SMITH JK, GILMORE JH, GAO W. Consistent Anterior-Posterior Segregation of the Insula during the First Two Years of Life. Cerebral Cortex 2015 May;25(5):1176-1187. [Epub ahead of print Nov 17, 2013] PMID: 24248433, PMC4397570

13. GAO W, GILMORE JH, SHEN D, SMITH JK, ZHU H, LIN W. The Synchronization within and Interaction between the Default and Dorsal Attention Networks in Early Infancy", Cerebral Cortex. 2013;23(3):594-603 PMID: 22368080, PMC3563337



14. GAO W, GILMORE JH, GIOVANELLO KS, SMITH JK, SHEN D, ZHU H, , LIN W. Temporal and Spatial Evolution of Brain Network Topology during the First Two Years of Life, PLoS One, 2011;6(9):e25278. Epub 2011 Sep 23. PMID: 21966479, PMC3179501

15. KNICKMEYER RC, KANG CT, WOOLSON S, SMITH JK HAMER RM, LIN W, GERIG G, STYNER M, GILMORE JH, Twin-Singleton Differences in Neonatal Brain Structure. Twin Res Hum Genet. 2011 Jun;14(3):268-76. PMID: 21623657, PMC3145253

16. FAN Y, SHI F, SMITH JK, GILMORE JH, LIN W, AND SHEN D, Brain Anatomical Networks in Early Human Brain Development Neuroimage, 2011 Feb 1;54(3):1862-71. [Epub ahead of print 2010 Jul 30] PMID: 20650319, PMC3023885

17. HUANG BY, KWOCK L, CASTILLO M, SMITH JK, Association of choline levels and tumor perfusion in brain metastases assessed with proton MR spectroscopy and dynamic susceptibility contrast-enhanced perfusion weighted MRI Technol Cancer Res Treat. 2010 Aug;9(4):327-37. PMID: 20626199

18. GILMORE JH, KANG C, EVANS DD, WOLFE HM, SMITH JK, LIEBERMAN JA, LIN W, HAMER RM, STYNER M, GERIG G, Prenatal and Neonatal Brain Structure and White Matter Maturation in Children at High Risk for Schizophrenia Am J Psychiatry. 2010 Sep;167(9):1083-91. [Epub ahead of print 2010 Jun 1] PMID: 20516153, PMC3105376

19. VICHINSKY EP, NEUMAYR LD, GOLD JI, et al. for the Neuropsychological Dysfunction and Neuroimaging Adult Sickle Cell Anemia Study Group. Neuropsychological Dysfunction and Neuroimaging Abnormalities in Neurologically Intact Adults With Sickle Cell Anemia JAMA. 2010;303(18):1823-1831. PMID: 20460621, PMC2892214

20. BULLITT E, ZENG D, MORTAMET B, GHOSH A, AYLWARD SR, LIN W, MARKS BL, SMITH JK. The effects of healthy aging on intracranial blood vessels visualized by magnetic resonance angiography NeurobiolAging 2010 Feb;31(2):290-300. Epub .PMID: 18471935, PMC2806428

21. MARKS BL, KATZ LM, LIU Z, STYNER M, SMITH JK, Aerobic Fitness and Obesity: Relationship to Cerebral White Matter Integrity in the Aging Cingulum. Br J Sports Med. 2011 Dec;45(15):1208-15.. [Epub ahead of print 2010 Jun 17] PMID: 20558529

22. GILMORE JH, SCHMITT JE, KNICKMEYER RC, SMITH JK, LIN W, STYNER M, GERIG G, NEALE MC. Genetic and Environmental Contributions to Neonatal Brain Structure: A Twin Study Hum Brain Mapp. 2010 Aug;31(8):1174-82. PMID: 20063301, PMC3109622

23. MARKS BL, KATZ LM, SMITH JK Exercise And The Aging Mind: Buffing The Baby

Boomer’s Body And Brain Phys Sportsmed. 2009 Apr;37(1):119-25. PMID: 20048497

24. BULLITT E, FN RAHMAN, JK SMITH, E KIM, D ZENG, LM KATZ, BL MARKS. The Effect of Exercise on the Cerebral Vasculature of Healthy Aged Subjects as Visualized by Magnetic Resonance Angiography. AJNR Am J Neuroradiol 2009 Nov;30(10):1857-63. Epub 2009 Jul 9. PMID: 19589885.



25. GAO W, ZHU H, GIOVANELLO KS, SMITH JK, SHEN D, GILMORE JH, LIN W.

Evidence on the emergence of the brain's default network from 2-week-old to 2-year-old healthy pediatric subjects. Proc Natl Acad Sci USA. 2009 Apr 21;106(16):6790-5. Epub 2009 Apr 7. PMID: 19351894, PMC2672537

26. ESCOLAR ML, POE MD, SMITH JK, GILMORE JH, KURTZBERG J, LIN W,

STYNER M. Diffusion Tensor Imaging Detects Abnormalities in the Corticospinal Tracts of Neonates with Infantile Krabbe Disease AJNR Am J Neuroradiol 2009 May;30(5):1017-21. Epub 2009 Apr 22. PMID: 19386732, PMC2763775

27. CHEN Y, AN H, ZHU H, STONE T, SMITH JK, HALL C, BULLITT E, SHEN D, LIN

W. White matter abnormalities revealed by diffusion tensor imaging in non-demented and demented HIV+ patients. Neuroimage 2009 Oct 1;47(4):1154-62. Epub 2009 Apr 17. PMID: 19376246, PMC4494862

28. HORTON AL, SMITH JK, STRAUSS RA Recurrence of Galloway Mowat syndrome

and associated prenatal imaging findings. Prenat Diagn. 2009 Mar;29(3):280-2. PMID: 19177459

29. GAO W, LIN W, CHEN Y, GERIG G, SMITH JK, JEWELLS V, GILMORE JH.

Temporal and Spatial Development of Axonal Maturation and Myelination of White Matter in the Developing Brain. AJNR Am J Neuroradiol. 2009 Feb;30(2):290-6. Epub 2008 Nov 11. PMID: 19001533, PMC2640448

30. MUKHERJEE N, KANG C, WOLFE HM, HERTZBERG BS, SMITH JK, LIN W,

GERIG G, HAMER RM, GILMORE JH. Discordance of Prenatal and Neonatal Brain Development in Twins. Early Hum Dev. 2009 Mar;85(3):171-5. Epub 2008 Sep 19. PMID: 18804925, PMC2696044

31. LIN W, ZHU Q, GAO W, CHEN Y, TOH CH, STYNER M, GERIG G, SMITH JK,

BISWAL B, GILMORE JH. Functional connectivity MR imaging reveals cortical functional connectivity in the developing brain. AJNR Am J Neuroradiol. 2008 Nov;29(10):1883-9. Epub 2008 Sep 10. PMID: 18784212, PMC2583167

32. GILMORE JH, SMITH L, WOLFE H, HERTZBERG B, SMITH JK, CHESCHEIR N,

EVANS D, KANG C, HAMER RM, LIN W, GERIG G. Prenatal Mild Ventriculomegaly Predicts Abnormal Development of the Neonatal Brain. Biol Psychiatry. 2008 Dec 15;64(12):1069-76. Epub 2008 Oct 2. PMID: 18835482, PMC2630424

33. KNICKMEYER RC, GOUTTARD S, KANG C, EVANS D, WILBER K, SMITH JK,

HAMER RM, LIN W, GERIG G, GILMORE JH A Structural MRI Study of Human Brain Development from Birth to Age 2. J Neurosci. 2008 Nov 19;28(47):12176-82. PMID: 19020011, PMC2884385

34. BUCKLE C, SMITH JK Choroid Plexus Papilloma of the Third Ventricle Pediatric

Radiology 37(7); p 725 July, 2007. Epub 2007 Apr 27. PMID: 17464502



35. IRVIN W, MACDONALD G, SMITH JK, KIM WY Dexamethasone-induced posterior reversible encephalopathy syndrome. JCO Journal of Clinical Oncology, 2007 Jun 10;25(17):2484-6. PMID: 17557962

36. BULLITT E, REARDON DA, SMITH JK. Brain Tumor Malignancy and Treatment

Monitoring: A Review of Micro and Macro MR Vascular Imaging (Lecture Notes in Computer Science Proceedings- MICCAI- 2007, 10 pages).

37. BULLITT E, REARDON DA, SMITH JK. A review of micro- and macrovascular

analyses in the assessment of tumor-associated vasculature as visualized by MR NeuroImage. 2007;37 Suppl 1:S116-9. Epub 2007 Apr 25. Available online at http://dx.doi.org/10.1016/j.neuroimage.2007.03.067, and made available for public access: http://www.pubmedcentral.gov/articlerender.fcgi?artid=2292206 PMID: 17512217, PMC2292206

38. GILMORE JH, LIN W, COROUGE I, VETSA YS, SMITH JK, KANG C, GU H, HAMER RM, LIEBERMAN JA, GERIG G. Early Postnatal Development of Corpus Callosum and Corticospinal White Matter Assessed with Quantitative Tractography AJNR Am J Neuroradiol 2007 Oct;28(9):1789-95.PMID: 17923457

39. BULLITT E, LIN NU, SMITH JK, ZENG D, WINER EP, CAREY LA, LIN W,

EWEND MG Blood vessel morphologic changes depicted with MR angiography during treatment of brain metastases: a feasibility study. Radiology 2007;245:824-830 published online before print October 22, 2007, DOI:2453061889 PMID: 17954616, PMC2615672 **Article chosen to be featured on the journal cover and in "This Month in Radiology," which highlights articles from original research appearing in that issue.**

40. BARNWELL JD, SMITH JK CASTILLO M Utility of Navigator-Prospective

Acquisition Correction Technique (PACE) for Reducing Motion in Brain MR Imaging Studies. AJNR Am J Neuroradiol 2007;Apr;28(4):790-1. PMID: 17416840

41. GILMORE JH, LIN W, PRASTAWA MW, LOONEY CB, VETSA YS, KNICKMEYER RC, EVANS DD, SMITH JK, HAMER RM, LIEBERMAN JA, GERIG G. Regional gray matter growth, sexual dimorphism, and cerebral asymmetry in the neonatal brain. J Neurosci. 2007 Feb 7;27(6):1255-60. PMID: 17287499, PMC2886661

42. SPAMPINATO MV, SMITH JK, KWOCK L, EWEND M, GRIMME JD, CAMACHO

DLA CASTILLO M. Cerebral Blood Volume Measurements and Proton MR Spectroscopy in Grading of Oligodendroglial Tumors. AJR Am J Roentgenol. 2007 Jan;188(1):204-12. PMID: 17179366

43. KWOCK L, SMITH JK, CASTILLO M, EWEND, MG, COLLICHIO F, MORRIS DE,

BOULDIN TW, CUSH S. Clinical Role of Proton Magnetic Resonance Spectroscopy in Oncology: Brain, Breast and Prostate Cancer. Lancet Oncolo 2006;7:859-868. PMID: 17012048

http://dx.doi.org/10.1016/j.neuroimage.2007.03.067



44. BULLITT E, LIN NU, EWEND MG, ZENG D, WINER EP, CAREY LA, SMITH JK. Tumor Therapeutic Response and Vessel Tortuosity: Preliminary Report in Metastatic Breast Cancer. Med Image Comput Comput Assist Interv. 2006;9(Pt 2):561-8. PMID: 17354817.

45. LOONEY CB, SMITH JK, MERCK LH, WOLFE HM, CHESCHEIR NC, HAMER

RM, GILMORE JH. Intracranial hemorrhage in asymptomatic neonates: prevalence on MR images and relationship to obstetric and neonatal risk factors. Radiology 2007 Feb;242(2):535-41. Epub 2006 Dec 19. PMID: 17179400

46. BULLITT E, ZENG D, GERIG G, AYLWARD S, JOSHI S, SMITH JK, LIN W,

EWEND MG Vessel tortuosity and brain tumor malignancy: A blinded study. Academic Radiology 2005; Oct;12(10):1232-40. PMID: 16179200 ****This paper was selected as the recipient of the 2006 Herbert M. Stauffer Award for Best Clinical Paper 2005 by the Association of University Radiologists.****

47. BRUBAKER LM, SMITH JK, LEE YL, LIN W,·CASTILLO M,· Hemodynamic and

Permeability Changes in Posterior Reversible Encephalopathy Syndrome Measured by Dynamic Susceptibility-Weighted MR Imaging. AJNR Am J Neuroradiol 2005 Apr;26(4):825-30. PMID: 15814928

48. TUCKER KA. ROBERTSON KR, LIN W, SMITH JK, AN H, CHEN Y, AYLWARD

SR, HALL CD. Neuroimaging in human immunodeficiency virus infection. Journal of Neuroimmunology 2004 Dec;157(1-2):153-62. PMID: 15579293

49. PARIKH AH, SMITH JK, EWEND MG, BULLITT E Correlation of MR Perfusion

Imaging and Vessel Tortuosity Parameters in Assessment of Intracranial Neoplasms. Technology in Cancer Research and Imaging 2004; Dec;3(6):585-90. PMID: 15560716.

50. SMITH JK, MATHEUS MG, CASTILLO M, Imaging Manifestations of

Neurosarcoidosis. AJR American Journal of Roentgenology 2004 Feb;182(2):289-95. PMID: 14736648.

51. BULLITT E, EWEND MG, AYLWARD S, LIN W, GERIG G, JOSHI S, JUNG I,

MULLER K, SMITH JK Abnormal Vessel Tortuosity as a Marker Of Treatment Response of Malignant Gliomas: Preliminary Report. Technology in Cancer Research and Imaging 2004 Dec;3(6):577-84. PMID: 15560715.

52. GILMORE JH, ZHAI G, WILBER K, SMITH JK, LIN W, GERIG G. 3 Tesla magnetic

resonance imaging of the brain in newborns Psychiatry Research, 2004 Nov 15;132(1): 81-5. PMID: 15546705.

53. CAMACHO DLA, SMITH JK, GRIMME JD, KEYSERLING HF, CASTILLO M.

Atypical MRI perfusion in developmental venous anomalies. AJNR Am J Neuroradiol. 2004 Oct;25(9):1549-52. PMID: 15502136.



54. BULLITT E, JUNG I, MULLER K, GERIG G, AYLWARD S, JOSHI S, SMITH JK, LIN W, EWEND M. Determining Malignancy of Brain Tumors By Analysis of Vessel Shape. Lecture Notes in Computer Science, Medical Image Computing and Computer-Assisted Intervention – MICCAI 2004: 7th International Conference, Saint-Malo, France, September 26-29, 2004. Proceedings, Part II 3217:645 – 653 DOI: 10.1007/b100270, Online Date: September 2004.

55. MATHEUS MG, CASTILLO M, EWEND MG, SMITH JK, KWOCK L, CUSH S,

MORRIS D. CT and MR Imaging after Placement of the Gliasite Radiation Therapy System to Treat Brain Tumor: Initial Experience. AJNR Am J Neuroradiol 2004 Aug;25(7):1211-7. PMID: 15313712.

56. MATHEUS MG, CASTILLO M, SMITH JK, ARMAO D, TOWLE D, MUENZER J.

Brain MRI findings in patients with mucopolysaccharidosis types I and II and mild clinical presentation. Neuroradiology. 2004 Aug;46(8):666-72. Epub 2004 Jun 17. PMID: 15205860

57. BULLITT E, GERIG G, AYLWARD S, JOSHI S, SMITH K, EWEND M, LIN W,

Vascular Attributes and Malignant Brain Tumors. Lecture Notes in Computer Science Volume 2878 / 2003 Proceedings of the Sixth Annual International Conference Medical Image Computing and Computer-Assisted Intervention - MICCAI 2003 pp. 671 – 679 DOI: 10.1007/b93810, Online Date: October 2003.

58. LONDOÑO A, CASTILLO M, LEE YZ, SMITH JK. ADC measurements in the

hippocampi in patients with temporal lobe seizures. AJNR Am J Neuroradiol 2003 Sep;24(8):1582-6. PMID: 13679274 .

59. THANANOPAVARN P, SMITH JK, CASTILLO M, On The AJR Viewbox: MR

Imaging of Angiosarcoma of the Calvarium. AJR American Journal of Roentgenology 2003 Nov;181(5):1432-3. PMID: 14573458.

60. KEYSERLING H, SMITH JK, CASTILLO M. Cranial Fasciitis of Childhood: A Case

Report, AJNR Am J Neuroradiol 2003 Aug;24(7):1465-7. PMID: 12917148.

61. CAMACHO DLA, SMITH JK, CASTILLO M. Differentiation between toxoplasmosis and lymphoma in AIDS patients using apparent diffusion coefficients. AJNR Am J Neuroradiol 2003 Apr;24(4):633-7. PMID: 12695194.

62. DROSSMAN DA, RINGEL Y, VOGT B, LESERMAN J, LIN W, SMITH JK,

WHITEHEAD W Alterations of Brain Activity Associated with Resolution of Emotional Distress and Pain in a Case of Severe IBS. Gastroenterology 2003 Mar;124(3):754-61. PMID: 12612913.

63. KHAN R, SMITH JK, CASTILLO M. Case Report: False Negative Contrast MRA in

the Setting of Carotid Artery Dissection Emergency Radiology 2002 Dec;9(6):320-2. Epub 2002 Nov 16. PMID: 15290543.

64. SMITH JK, CASTILLO M, KWOCK L. Proton MR spectroscopy of brainstem lesions.

Neuroradiology 2002 Oct;44(10):825-9. Epub 2002 Aug 10. PMID: 12389131



65. KWOCK L SMITH JK, CASTILLO M, et al. Clinical applications of proton MR spect-roscopy in oncology. Technology in Cancer Diagnosis and Treatment 2002; 1(1): 1-10.

66. RUMBOLDT Z, CASTILLO M, SMITH JK. The palatovaginal canal: can it be

identified on routine CT and MR imaging? AJR American Journal of Roentgenology 2002 Jul;179(1):267-72. PMID: 12076948.

67. RUMBOLDT Z, SMITH JK, CASTILLO M. Triple blowout orbital fracture. Emergency

Radiology 2001; 8: 341-343.

68. CASTILLO M, SMITH JK, KWOCK L. Proton MR spectroscopy in patients with acute temporal lobe seizures. AJNR Am J Neuroradiol 2001; 22: 152-157.

69. BULLITT E, AYLWARD S, SMITH JK, MUKHERJI SM, JIROUTEK M, MULLER

K. Symbolic Description of Intracerebral Vessels Segmented from MRA and Evaluation by Comparison with X-Ray Angiograms. Medical Image Analysis 5: 157-169, 2001. CID 11516709.

70. CASTILLO M, SMITH JK, KWOCK L, WILBER K. Apparent diffusion coefficients in

the evaluation of high-grade cerebral gliomas. AJNR Am J Neuroradiol 2001; 22: 60-64.

71. CASTILLO M, SMITH JK, KWOCK L. Correlation of myoinositol levels and grading of cerebral astrocytomas. AJNR Am J Neuroradiol 2000; 21: 1645-1649.

72. CASTILLO M, MUKHERJI SK, ISAACS D, SMITH JK. Cerebral infarctions:

evaluation with single axis versus trace diffusion-weighted MR imaging. AJR American Journal of Roentgenology 2000; 174: 853-857.

73. SMITH JK, KWOCK L, CASTILLO M. Effects of gadolinium-DTPA on single volume

proton MR spectroscopy. AJNR Am J Neuroradiol 2000 Jun-Jul;21(6):1084-9. PMID: 10871019

74. CASTILLO M, ARBELAEZ A, SMITH JK, FISHER LL. Diffusion-weighted MR

imaging in vertebral metastatic disease. AJNR Am J Neuroradiol. 2000 May;21(5):948-53.

75. SMITH JK, ARMAO DM, SPECTER BB, CASTILLO M. Danger space infection:

infection of the neck leading to descending necrotizing mediastinitis. Emergency Radiology 1999; 6: 129-132.

76. CASTILLO M, ARBELAEZ A, FISHER LL, SMITH JK, MUKHERJI SK. Diffusion-

weighted imaging in patients with cervical spondylosis: initial observations. International Journal of Neuroradiology 1999: 5: 79-85.

77. SMITH JK, ARMAO DM, KHAIRI SA, GANTT CB, CASTILLO M. Dermoid tumor

of the spine with rupture. Case of the Week, eAJR American Journal of Roentgenology 1999, 172:(e4).

78. GREEN C, SMITH JK, CASTILLO M. Imaging of head trauma in child abuse victims.

Emergency Radiology 3:34-42, 1996.



79. SMITH JK, MAH JK, CASTILLO M. Brain MR imaging findings in two patients with

Alpers’ syndrome. Clinical Imaging 20:235-237, 1996.

80. CASTILLO M, SCATLIFF JH, KWOCK L, GREEN JJ, SUZUKI K, CHANCELLOR K, SMITH JK. Postmortem MR imaging of lobar infarction with pathologic and in vivo Correlation. Radiographics 16:241-250, 1996.

81. SMITH JK, CASTILLO M, WILSON JD. MR characteristics of low-flow facial

vascular malformations in children and young adults. Clinical Imaging 19:109-117, 1995.

82. CASTILLO M, SMITH JK. Imaging features of acute head and spine injuries secondary to difficult deliveries. Emergency Radiology 2(1):7-12, 1995.

83. CASTILLO M, SMITH JK, MUKHERJI SK. MR appearance of cerebral cortex in

children with and without a history of perinatal anoxia: preliminary observations. AJR American Journal of Roentgenology 164:1481-1484, 1995.

84. SMITH JK, CASTILLO M. Internet-accessible radiology teaching file. Emergency

Radiology 2(1):111-113, 1995.

85. CASTILLO M, CARRIER DA, SMITH JK. Spinal cord infarction after solitary rib fracture. Emergency Radiology 2(2):105-108, 1995.

86. THOMPSON J, CASTILLO M, REDDICK RL, SMITH JK, SHOCKLEY W.

Nasopharyngeal nonossifying variant of ossifying fibromyxoid tumor: CT and MR findings. AJNR: Am J Neuroradiol 16:1132-1134, 1995.

87. CASTILLO M, GREEN C, KWOCK L, SMITH JK, WILSON D, SCHIRO S,

GREENWOOD R. Proton MR spectroscopy in patients with neurofibromatosis type I: evaluation of hamartomas and clinical correlation. AJNR: Am J Neuroradiol 16:141-147, 1995.

88. SMITH JK, CASTILLO M, MUKHERJI S, BUENTING J, DRAKE A. Imaging of

nasopharyngeal atresia. AJNR: Am J Neuroradiol 16(9):1936-1938, 1995.

89. REITZ LA, SMITH JK, CASTILLO M. Acute spinal cord injury: Clinical aspects and magnetic resonance imaging. Emergency Radiology 1(5):221-227;1994.

90. SMITH JK, MERTEN DF, CASTILLO M. Imaging of the central nervous system in

child abuse: a computer aided instructional program. Emergency Radiology 1(5):228-230, 1994.

91. SMITH JK, CARSON GC, JOHNSON JD, HARRIS JH. An Approach to Fractures of

the Midface: An Interactive Tutorial Emergency Radiology 1(2):78-80, 1994.

92. EFTEKHARI F, SMITH JK. Sonography of the scrotum after orchiectomy: Normal and abnormal findings. AJR American Journal of Roentgenology:160:543-547, 1993.



93. CARDEN DL, SMITH JK, KORTHUIS RJ. Oxidant-mediated, CD18 dependent microvascular dysfunction induced by complement-activated granulocytes. Am J Physiol 260:H1144-H1152, 1991.

94. SMITH JK, CARDEN DL, KORTHUIS RJ. Activated neutrophils increase

microvascular permeability in skeletal muscle: role of xanthine oxidase. J -Appl Physiol 70(5):2003-2009, 1991.

95. CARDEN DL, SMITH JK, KORTHUIS RJ. Neutrophil-mediated microvascular

dysfunction in postischemic canine skeletal muscle. Role of granulocyte adherence. Circ Res 66(5):1436-1444, 1990.

96. LAUGHLIN MH, SIMPSON T, SEXTON WL, BROWN OR, SMITH JK, KORTHUIS

RJ. Skeletal muscle oxidative capacity, antioxidant enzymes, and exercise training. J Appl Physiol 68(6):2337-2343, 1990.

97. KORTHUIS RJ, SMITH JK, CARDEN DL. Role of xanthine oxidase in postischemic

granulocyte infiltration and microvascular injury in canine gracilis muscle. Physiologist 158, 1989.

98. KORTHUIS RJ, SMITH JK, CARDEN DL. Hypoxic reperfusion attenuates

postischemic microvascular injury. Am J Physiol 256:H315-H319, 1989.

99. CARDEN DL, SMITH JK, ZIMMERMAN BJ, KORTHUIS RJ, GRANGER DN. Reperfusion injury following circulatory collapse: The role of reactive oxygen metabolites. J Critical Care Med 4(4):294-307, 1989.

100. CARDEN DL, SMITH JK. Pneumonias. Emergency Medicine Clinics of North

America: 7(2):255-278, 1989.

101. SMITH JK, GRISHAM MB, GRANGER DN, KORTHUIS RJ. Free radical defense mechanisms and neutrophil infiltration in post-ischemic skeletal muscle. Am J Physiol 256:H789-H793, 1989.

102. SMITH JK, CARDEN DL, KORTHUIS RJ. Role of xanthine oxidase in postischemic

microvascular injury in skeletal muscle. Am J Physiol 257:H1782-H1789, 1989.

103. SMITH JK, CARDEN DL, GRISHAM MB, GRANGER DN, KORTHUIS RJ. Role of iron in post-ischemic microvascular injury. Am J Physiol 256:H1472-H1477, 1989.

104. YRLE LF, SMITH JK, BENOIT JN, GRANGER DN, KORTHUIS RJ. Role of

glucagon in the intestinal hyperemia associated with early experimental diabetes mellitus. Am J Physiol 255:G542-G546, 1988.



Articles In Preparation or Submitted to Refereed Journals: (underlined authors are students or trainees)

105. WEI GAO, PH.D., ANDREW, P. SALZWEDEL, ROBERT EMERSON, PH.D., SARAEL ALCAUTER, PH.D., BARBARA D. GOLDMAN, PH.D., L. FREDRIK JARSKOG, M.D., J. KEITH SMITH, PH.D., M.D., WEILI LIN, PH.D., JOHN H. GILMORE, M.D. Altered functional connectivity in neonates at risk for schizophrenia and bipolar illness Submitted to Biological Psychiatry 2016

106. FENG SHI, PEW-THIAN YAP, J. KEITH SMITH, KELLY S. GIOVANELLO, CANDICE GOERGER, WEILI LIN, KEVIN M. GUSKIEWICZ, DINGGANG SHEN Disrupted Anatomical Brain Connectivity in Retired Professional Football Players (In Preparation, 2015)

107. C EDGERLY, BS; J K SMITH, MD, PHD; C SAMS, MD, S WOOLSON, PHD; J H GILMORE, MD; B GOLDMAN; ET AL. Intracranial Hemorrhage in Asymptomatic Neonates: MR and Developmental Findings at 1 and 2 Years (In Preparation, 2016)

108. VAN HORN MH, SALVADOR F, BULLITT E, AND SMITH JK, Automatic Selection of an Arterial Input Function in MR Perfusion Imaging Using a Vessel Atlas (In Preparation, 8 pages, 2016)

109. SIGOUNAS DG, STEWART PW, KILPATRICK M, BULLITT E, SMITH JK, EWEND MG, A New Measurement Criterion For Evaluation Of Metastatic Brain Lesions (In Preparation, 19 pages, 2016)

Articles in Non-Refereed Journals and Invited Articles: (underlined authors are students or trainees)

110. SMITH JK, LURY KM, CASTILLO M. Imaging of spinal and spinal cord tumors. Seminars in Roentgenology 41(4):274-293, October, 2006. PMID: 17010691

111. LURY K, SMITH JK, CASTILLO M. Imaging of spinal infections. Semin Roentgenol.

2006 Oct;41(4):363-79. PMID: 17010695 112. SMITH JK. Parasellar Tumors: suprasellar and cavernous sinuses. Topics in Magnetic

Resonance Imaging 16(4):307-315, 2005. PMID: 16785846

113. LURY KM, SMITH JK, MATHEUS MG, CASTILLO M, Neurosarcoidosis-Review of Imaging Findings. Seminars in Roentgenology 2004 Oct;39(4):495-504. PMID: 15526533

114. SMITH JK, KWOCK L, CASTILLO M. Single- and multivolume MR spectroscopy of

brain tumors. Oncologic Imaging. Categorical Course Review, ARRS, 2003



Abstracts: (underlined authors are students or trainees)

1. C ANDERS, A DEAL, V ABRAMSON, M LIU, AM STORNIOLO, J CARPENTER, S PUHALLA, R NANDA, A MELHEM-BERTRANDT, NU LIN, PK MARCOM, C VAN POZNAK, V STEARNS, M MELISKO, JK SMITH, O KARGINOVA, EP WINER, CM PEROU, AC WOLFF, LA CAREY, on behalf of the Translational Breast Cancer Research Consortium: TBCRC 018: Phase II study of iniparib plus chemotherapy to treat triple-negative breast cancer (TNBC) central nervous system (CNS) metastases (mets). Presented at, and selected for a Poster Discussion Session at the ASCO Annual Meeting, May 31-June 4, 2013, Chicago, IL

2. C EDGERLY, BS; J K SMITH, MD, PHD; C SAMS, MD, S WOOLSON, PHD; J H GILMORE, MD; B GOLDMAN; ET AL. Intracranial Hemorrhage in Asymptomatic Neonates: MR and Developmental Findings at 1 and 2 Years Presented at the Annual meeting of the Radiology Society of North America (RSNA), Chicago, Il. Nov 2012.

3. WEI GAO, JOHN GILMORE, DINGGANG SHEN, KEITH SMITH, HONGTU ZHU, WEILI LIN. The Development of Default and Dorsal Attention Networks in Early Infancy, OHBM'12, Beijing, China, Jun. 10-14, 2012.

4. FENG SHI, PEW-THIAN YAP, J. KEITH SMITH, KELLY S. GIOVANELLO, CANDICE GOERGER, WEILI LIN, KEVIN M. GUSKIEWICZ, DINGGANG SHEN Disrupted Anatomical Brain Connectivity in Retired Professional Football Players, ISMRM'11, Montreal, Quebec, Canada, May 7-13, 2011. (Oral Presentation)

5. MARKS BL, KATZ LM, STYNER M, ROBERTSON K, SMITH JK. Smaller Brain

Volumes and Subtle Cognitive Decline in Overweight Healthy Older Adults. Accepted for presentation in a slide session at the 58th Annual Meeting and 2nd World Congress of Exercise is Medicine of the American College of Sports Medicine, Denver, Colorado, May 31 - June 4, 2011. Abstract will be published in Medicine and Science in Sports and Exercise, Volume 43:5 Supplement 2011.

6. TANG S, SMITH JK, MARKS BL, LIN W, GUSKIEWICZ K, SHEN D. MRI-based identification of brain atrophy in retired professional football players. Neuroradiology, Cognitive and Related Miscellaneous Disorders, SSM15. Radiology Society of North America (RSNA) Conference, Chicago, Il. 02 Dec 2009. http://rsna2009.rsna.org/search/search.cfm?action=delete&filter=Subspecialty&value=301102126

7. GILMORE JH, ZHU Q, GAO W, CHEN Y, TOH CH, STYNER M, GERIG G, SMITH JK, BISWAL B, LIN W. Development Of Resting State Networks From Birth To Age 2 Years Schizophrenia Bulletin, 35: 177-177 Suppl. 1 MAR 2009 ISSN: 0586-7614

8. HUANG BY, KWOCK L, SMITH JK, CASTILLO M. Choline levels in brain

metastases from non-small cell lung cancer and other cell types: clinical and therapeutic implications. RSNA Scientific Annual Meeting 2008, Chicago, December 12, 2008

9. MARKS BL, KATZ LM, STYNER M, SMITH JK. Higher aerobic fitness is related to

greater fractional anisotropy in the anterior-medial segments of the cingulum in older adults. UNC Radiology-BRIC 2008 Symposium.

http://rsna2009.rsna.org/search/search.cfm?action=delete&filter=Subspecialty&value=301102126

http://rsna2009.rsna.org/search/search.cfm?action=delete&filter=Subspecialty&value=301102126



10. RAHMAN, F, SMITH K, BULLITT E, KATZ L, MARKS B. Relationship of exercise

to cerebral vascularture and blood flow in older adults. RSNA Nov. 2008 Conference.

11. MARKS BL, KATZ LM, STYNER M, SMITH JK, BULLITT E. Body composition is related to white matter integrity in the aging brain. GSA Conference, Nov. 22 2008.

12. RAHMAN F, SMITH K, BULLITT E, MARKS B. Relationships between exercise and

cerebral blood flow in older adults. ASNR, New Orleans, May 31–June 5, 2008.

13. MARKS BL, KATZ LM, SMITH JK, STYNER M, ROBERTSON K, SHIELDS E, GUSKIEWICZ K. Role of recreational sport participation on cerebral white matter integrity in older adults. Annual Radiology-BRIC Symposium, University of North Carolina at Chapel Hill, May 10, 2007.

14. ELBABAA SK, SIGOUNAS D, KWOCK L, SMITH JK, CUSH S, EWEND MG.

Evaluation of MR spectroscopy in diagnosis of periventricular enhancing brain lesions: Primary CNS lymphoma versus high-grade glioma. Neuro-Oncology, 9 (4): 578-579 OCT 2007 ISSN: 1522-8517

15. MARKS BL, KATZ LM, STYNER M, SMITH JK, BABBITT M, HAWKINS

J, BULLITT E. (2008). Aerobic fitness impact on cerebral white matter integrity in the cingulum. Medicine and Science in Sports and Exercise 40:5 Supplement (May, 2008).

16. SIGOUNAS DG, KILPATRICK M, BULLITT E, SMITH JK, EWEND MG

Interobserver Comparison of a New Measurement Technique for the Assessment of Metastatic Brain Lesions with Uni-dimensional Measurement, Bi-dimensional Measurement, and Volumetric Analysis. ASNR 2007.

17. GILMORE JH, LIN W, EVANS DD, KANG C, HAMER RM, SMITH JK,

LIEBERMAN JA, GERIG G. Early brain development in children at high risk for schizophrenia Schizophrenia Bulletin, 33 (2): 333-333 MAR 2007 ISSN: 0586-7614

18. BUIE LW, LINDLEY C, SHIH T, EWEND M, SMITH JK, SKELTON M, KWOCK L,

MORRIS D, TUCKER C, AND COLLICHIO F. Plasma pharmacokinetics and cerebrospinal fluid concentrations of erlotinib in high-grade gliomas: A novel, phase I, dose escalation study. Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. Vol 25, No. 18S (June 20 Supplement), 2007:2054.

19. KILPATRICK MR, LINN NU, SMITH JK, WINER EP, BULLITT E, CAREY LA,

EWEND MG. Superiority of bi-dimensional measurements compared to RECIST in measuring response of metastatic brain tumors. Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings Part I. Vol 24, No. 18S (June 20 Supplement), 2006:1542.

20. LEE YZ,·SMITH JK,·EWEND M,·MORRIS D,·CASTILLO M. Evaluation of

Metastases Post Radiation using MR Dynamic Susceptibility Perfusion Measurements. Proceedings, ASNR 2006, Presented at the 44th annual meeting of the American Society of Neuroradiology, April 29 - May 5, 2006 in San Diego, California.



21. PEYRE, J.·SMITH, JK.·JOMIER, J.·CASTELLANO, F.·HOLLINGSHEAD, M.·AYLWARD, S.·CASTILLO, M. Lupus CNS Vasculitis: Circulatory Pathology Demonstrated with Perfusion MRI. Proceedings, ASNR 2006, Presented at the 44th annual meeting of the American Society of Neuroradiology, April 29 - May 5, 2006 in San Diego, California.

22. LOONEY CB, SMITH JK, FAGAN LH, HAMER RM, GILMORE JH, Intracranial

Hemorrhage in Asymptomatic Neonates: Prevalence on 3.0 T MR Scans and Relationship to Obstetric and Neonatal Risk Factors. Radiology supplement November 2005:p683 Presented at the RSNA 91st Scientific Assembly and Annual Meeting in Chicago IL, November 27 - December 2, 2005. ***Abstract selected for RSNA Trainee Research Prize- Dr. Looney received $1000 prize.***

23. SMITH JK, VIVERT C, PEYRE J, ROBERTSON K, WILBER K, LIN W, et al.

Circulatory Pathology in HIV-associated Dementia Assessed by Dynamic Susceptibility MR Perfusion at 3.0T. Radiology supplement November 2005:p206 Presented at the RSNA 91st Scientific Assembly and Annual Meeting in Chicago IL, November 27 - December 2, 2005.

24. GILMORE J, LOONEY C, VESTA Y, SMITH JK, LIN W, LIEBERMAN JA, GERIG

G. Early postnatal brain structure and development in humans: Sexual dimorphism and cerebral asymmetry are present at birth Neuropsychopharmacology, 30: S154-S154 Suppl. 1 DEC 2005 ISSN: 0893-133X

25. AN H, CHEN Y, SMITH JK, HALL C, ROBERTSON K, WILBER K, et al. Whole

Brain Diffusion Tensor Analysis in HIV Patients at Various Clinical Stages. Radiology supplement November 2005:p516 Presented at the RSNA 91st Scientific Assembly and Annual Meeting in Chicago IL, November 27 - December 2, 2005.

26. LURY KM, SMITH JK, MATHEUS MG, CASTILLO M, Review of Imaging Findings

in Neurosarcoidosis Proceedings, ASNR 2004, Presented at the 43rd annual meeting of the American Society of Neuroradiology, May 23-27th 2005, in Toronto, Ontario, Canada.

27. PARIKH AH, SMITH JK, EWEND MG, BULLITT E Correlation of MR Perfusion

Imaging and Vessel Tortuosity Parameters in Assessment of Intracranial Neoplasms. Proceedings, ASNR 2005, Presented at the 43rd annual meeting of the American Society of Neuroradiology, May 23-27th 2005, in Toronto, Ontario, Canada.

28. SMITH JK, KWOCK L, CASTILLO M. Brain Metastasis from Lung Cancer Show

Distinct Pattern on Proton MRS. Proceedings, ASNR 2005, Presented at the 43rd annual meeting of the American Society of Neuroradiology, May 23-27th 2005, in Toronto, Ontario, Canada.

29. SPAMPINATO MV, KWOCK L, SMITH JK, GRIMME J, CAMACHO DL,

CASTILLO M. Differentiation of low and high-grade oligodendroglial tumors using perfusion and proton spectroscopy MR imaging. AJR (S) 2005; 184: 4-5. Presented at the 105th Annual ARRS Meeting, New Orleans, Louisiana, May 15-20 2005.



30. CAMACHO DL, SMITH JK, GRIMME JD, KEYSERLING HF, SPAMPINATO MV, CASTILLO M. Perfusion MRI abnormalities in asymptomatic developmental venous anomalies. AJR (S) 2005; 184: 64. Presented at the 105th Annual ARRS Meeting, New Orleans, Louisiana, May 15-20 2005.

31. SPAMPINATO, M. V.·KWOCK, L.·SMITH, J.K.·CAMACHO, D. L.·GRIMME, J.

D.·CASTILLO, M. Differentiation Of Low- And High-Grade Oligodendroglial Tumors Using Perfusion And Proton Spectroscopy MR Imaging Proceedings, ASNR 2005, Presented at the 43rd annual meeting of the American Society of Neuroradiology, May 23-27th 2005, in Toronto, Ontario, Canada.

32. SMITH JK, WILBER K, KWOCK L, LIN W, FISCHER L, ZEISEL S. Effect of

Dietary Choline Depletion on Brain Choline & Memory Function Measured by MR Spectroscopy and Functional MR. FASEB Journal, 18(5) pA913. Presented at the annual FASEB meeting, April 19-21, 2004, Washington DC.

33. BULLITT E, JUNG I, MULLER K, GERIG G, AYLWARD S, JOSHI S, SMITH JK,

LIN W, EWEND M. Determining Malignancy of Brain Tumors By Analysis of Vessel Shape. Proceedings of the Seventh Annual International Conference Medical Image Computing & Computer Assisted Intervention MICCAI 2004.

34. SMITH JK, HALL CD, ROBERTSON KR, WILBER K, CASTILLO M, LIN W.

Decreased brain activation in patients with HIV associated dementia measured by fMRI. Proceedings, ASNR 2004, p 309 Presented at the 42nd annual meeting of the American Society of Neuroradiology, June 7-11, 2004, in Seattle, WA.

35. CASTILLO M, MATHEUS G, SMITH JK. Imaging of developmental venous

anomalies with atypical features. Proceedings, ASNR 2004, pp 457-58. Presented at the 42nd annual meeting of the American Society of Neuroradiology, June 7-11, 2004, in Seattle, WA. Also appears in: Neurographics (www.asnr.org).

36. COOL DW, SMITH JK, HALL CD, ROBERTSON KR, WILBER K, AYLWARD SR,

LIN W. Circulatory changes in cerebral perfusion resulting from HIV associated dementia. Proceedings, ASNR 2004, p 240 Presented at the 42nd annual meeting of the American Society of Neuroradiology, June 7-11, 2004, in Seattle, WA.

37. GRIMME JD, SMITH JK, THURNHER M, AND CASTILLO M. Atypical Diffusion-

Weighted Imaging Features in Brain Abscesses. Electronic exhibit at the 104th Annual Meeting of the American Roentgen Ray Society, Miami, Florida, May 2-7, 2004.

38. CASTILLO M, MATHEUS G, SMITH JK. Imaging of developmental venous

anomalies with atypical features. Proceedings, ASNR 2004, p 457 Presented at the 42nd annual meeting of the American Society of Neuroradiology, June, 2004, in Seattle, WA.

39. HAMILTON, JD; REDDING-LALLINGER, R; SMITH, JK; et al. Functional MRI

investigation of pediatric sickle cell subjects and their siblings. BLOOD, 102 (11): 28B-28B 3813 Part 2 NOV 16 2003 ISSN: 0006-4971



40. MATHEUS MG, CASTILLO M, MUENZER J, SMITH JK, TOWLE D. Correlation of MRI and clinical features in patients with mucopolysaccharidoses types 1 and 2. Abstract Book, 2003 ARRS, AJR 2003, 180: 37 (Presented at the 103rd Annual Meeting of the American Roentgen Ray Society, May 4-9, 2003, San Diego, California).

41. CAMACHO D, SMITH JK, CASTILLO M. Differentiation between toxoplasmosis and

lymphoma in AIDS patients using apparent diffusion coefficients. Abstract Book, 2003 ARRS, AJR 2003, 180: 46 (Presented at the 103rd Annual Meeting of the American Roentgen Ray Society, May 4-9, 2003, San Diego, California).

42. HAMILTON J, ATAGA K, REDDING-LALLINGER R, HILLIKER D, SMITH JK,

LIN W. Functional MRI investigation of pediatric patients with sickle cell disease. Radiology supplement November 2003:265 Presented at the Annual RSNA Meeting, Chicago, Il, Nov 29-Dec 3, 2003.

43. BRUBAKER L, CHEN E, MATSUSHIMA G, SMITH JK, AN H, LIN W. The use of

diffusion tensor imaging to evaluate demyelination processes in mice. Radiology supplement November 2003:550 Presented at the Annual RSNA Meeting, Chicago, Il, Nov 29-Dec 3, 2003.

44. CAMACHO D, SMITH JK, CASTILLO M. Diffusion weighted MR imaging of

toxoplasmosis and lymphoma in acquired immunodeficiency syndrome. Proceedings, ASNR 2003, p 13 Presented at the annual meeting of the American Society of Neuroradilogy, April 26- May 2, 2003, in Washington, DC.

45. BRUBAKER LM, LEE YL,·LIN W,·CASTILLO M,·SMITH JK Hemodynamic and

Permeability Changes in Posterior Reversible Encephalopathy Syndrome Measured by Dynamic Susceptibility-Weighted MR Imaging. Proceedings, ASNR 2003, p 192. Presented at the annual meeting of the American Society of Neuroradiology, April 26- May 2, 2003, in Washington, DC.

46. CAMACHO DLA, SMITH JK, CASTILLO M Differentiation Between Toxoplasmsosis

and Lymphoma in AIDS Patients Using Apparent Diffusion Coefficients AJR American Journal of Roentgenology (S) 2002; 180: 46. Presented at the 103rd annual meeting of the American Roentgen Ray Society, May 4-9, 2003, in San Diego, CA.

47. MATHEUS G, CASTILLO M, MUENZER J, SMITH JK, TOWLE D. MRI of brain

findings in mucopolysacharidoses types 1 and 2. Presented at the American Roentgen Ray Society Meeting 2003, AJR American Journal of Roentgenology (S) 2002; 180: 37.

48. SMITH JK, KWOCK L, LONDOÑO A, CASTILLO M. Proton MR spectroscopy of

brainstem lesions. Radiology supplement November 2002 225(p):335. Presented at the Annual RSNA Meeting, Chicago, Il, Nov 26-Dec 1, 2002.

49. RINGEL Y, DROSSMAN DA, LIU H, LIN W, SMITH JK, KEETER L, AN H, VOGT

B, LESERMAN J, WHITEHEAD W Anterior Shift of Cingulate Activity with Painful Rectal Distension in Subjects with Sexual/Physical Abuse. Gastroenterology, 122(4) Supplement, April 2002, A-311.



50. RINGEL Y, DROSSMAN DA, LIU H, LIN W, SMITH JK, KEETER L, AN H, VOGT B, LESERMAN J, WHITEHEAD W fMRI of Cingulate (ACC) Activation to Painful Rectal Distension in ABS and Sexual/Physical Abuse. Gastroenterology, 122(4) Supplement, April 2002, A-311.

51. MATHEUS G, CASTILLO M, SMITH JK, TOWLE D, MUENZER J. MR imaging in

mucopolysacharidoses with mild clinical presentation. Presented at and published in the Syllabus for the 2002 Annual Meeting of American Society of Neuroradiology, p 292, Vancouver BC, Canada, May 11-17, 2002.

52. SMITH JK, LEE Y, LIN W, EWEND M, CASTILLO, KWOCK L. Radiation necrosis

following stereotatic radiosurgery shows peripheral increased perfusion with perfusion sensitive contrast-enhanced MR imaging. Presented at and published in the Syllabus for the 2002 Annual Meeting of American Society of Neuroradiology, p 140, Vancouver BC, Canada, May 11-17, 2002.

53. CASTILLO M, SMITH JK, KWOCK L. Proton MR spectroscopy of brainstem lesions:

preliminary experience. Proceedings, ASNR 39th Annual Meeting, 2001, Boston, MA April 23-27, p 47.

54. CASTILLO M, SMITH JK, KWOCK L. Presence of lactate lateralizes abnormal

hippocampi by ictal proton MR spectroscopy. Proceedings, ASNR 39th Annual Meeting, 2001, p 15. Boston, MA April 23-27.

55. CASTILLO M, KWOCK L, SMITH JK. Correlation between myoinositol level and

grading of cerebral gliomas. Proceedings, ASNR 38th Annual Meeting, Atlanta, GA, April 2-8, 2000.

56. CASTILLO M, KWOCK L, SMITH JK, WILBER K. Apparent diffusion coefficients in

the evaluation of high-grade astrocytomas. Proceedings, ASNR 38th Annual Meeting, Atlanta, GA, April 2-8, 2000.

57. SMITH JK, KWOCK L, HUDSON LC, TOMKINS MB, ENGLISH RV, BOLD-

FLETCHER NO, CASTILLO M. Acute changes in brain metabolites following infection with feline immunodeficiency virus in cats. Presented at and published in the syllabus for the Annual RSNA Meeting, Chicago, Il, Nov 26-Dec 1, 2000.

58. CLARK MB, CASTILLO M, FISHER L, MUKHERJI SK, SMITH JK. Comparison of

GRE and MEDIC MR images in the evaluation of the cervical spine. Proceedings of the 38th Annual ASNR Meeting 2000 p 10.

59. KOWCK L, CASTILLO M, SMITH JK. Correlation between myoinositol level and

grading of cerebral gliomas. Proceedings of the 38th Annual ASNR Meeting 2000 p 127.

60. KWOCK L, CASTILLO M, SMITH JK, WILBER K. Apparent diffusion coefficients in the evaluation of high-grade astrocytomas. Proceedings of the 38th Annual ASNR Meeting, 2000, p24.



61. SMITH JK, ARMAO DM, CASTILLO M. Imaging of central nervous system congenital malformations with pathologic correlation: a computer-aided instructional program. Radiology 1999; 213 (P): 498. (Presented at the annual meeting of the Radiological Society of North America, November 27-December 2, 1999 Chicago, Illinois)

62. CASTILLO M, ARBELAEZ A, MUKHERJI SK, SMITH JK, FISHER L. Diffusion-

weighted MR imaging in patients with cervical degenerative disease. Radiology 1999; 213 (P): 391.

63. CASTILLO M, ARBELAEZ A, SMITH JK, FISHER L. Diffusion-weighted imaging

vs. conventional MRI in spinal metastatic disease. Proceedings of the 37th Annual ASNR Meeting 1999, p 198.

64. SMITH JK, CASTILLO M, KWOCK L. Effects of gadolinium DTPA on single volume

H-1 magnetic resonance spectroscopy (MRS) Proceedings of the 37th Annual ASNR Meeting 1999, p 173.

65. KWOCK L, CASTILLO M, SMITH JK. Comparison of proton MR spectral patterns of

glioblastoma multiforme (GBM) versus metastatic brain tumors. Proceedings of the 37th Annual ASNR Meeting 1999, p 58.

66. CASTILLO M, KWOCK L, FARMER CB, SMITH JK, GREENWOOD R, WHITT JK,

MUKHERJI SK, SAID S. Cerebral 1H-MRS in NF-1 children with cognitive disabilities. ASNR annual meeting syllabus 1996, p 86.(Presented at the American Society of Neuroradiology Annual Meeting, 1996)

67. CASTILLO M, KWOCK L, GREEN C, SMITH JK et al. Proton MRS in patients with

NF-1: evaluation of hamartomas and clinical correlation. Year Book of Neuroradiology 1995.

68. SCATLIFF JH, KWOCK L, CHANCELLOR KE, SMITH JK, CASTILLO M.

Postmortem MRI of AIDS brains. Proceedings of the Annual ASNR Meeting 1995, p 229.

69. CASTILLO M, MUKHERJI SK, SMITH JK, QUENCER RM. Segmental and generalized patterns of spinal cord and nerve root enhancement: differential diagnosis. Proceedings of the Annual ASNR Meeting 1995, p 222. (Presented at the American Society of Neuroradiology Annual Meeting, Chicago, Il, April 1995)

70. CASTILLO M, MUKHERJI S, SMITH JK. Insults to the radial-glial unit: spectrum of

abnormalities ranging from hydranencephaly to cortical dysplasia. Proceedings of the Annual ASNR Meeting 1995, p215. (Presented at the American Society of Neuroradiology Annual Meeting, Chicago, Il, April 1995)

71. LEITE CC, JINKINS JR, CASTILLO M, SMITH JK et al. MR of subarachnoid seeding

from glial tumors. Proceedings of the Annual ASNR Meeting 1995, p 43. (Presented at the American Society of Neuroradiology Annual Meeting, Chicago, Il, April 1995)



72. THOMPSON JE, CASTILLO M, SMITH JK. Imaging of central nervous system hemorrhage: a computer aided instructional program. AJR American Journal of Roentgenology 164(3)Supl:167, 1995. (Presented at the 95th annual meeting of the American Roentgen Ray Society, April 30-May 5, 1995 Washington, DC.)

73. SMITH JK, CASTILLO M. Internet-accessible radiology teaching file. AJR American Journal of Roentgenology 164(3)Supl:166, 1995. (Presented at the 95th annual meeting of the American Roentgen Ray Society, April 30-May 5, 1995 Washington, DC.)

74. NOONE TC, CASTILLO M, SMITH JK. Imaging of central nervous system neoplasms

in children: a computer aided instructional program. AJR American Journal of Roentgenology 164(3)Supl:168, 1995. (Presented at the 95th annual meeting of the American Roentgen Ray Society, April 30-May 5, 1995 Washington, DC.)

75. THOMPSON JE, CASTILLO M, SMITH JK, MUKHERJI SK. CT and MRI of

fibroosseous lesions of the face and base of skull. AJR American Journal of Roentgenology 164(3)Supl:212, 1995. (Presented at the 95th annual meeting of the American Roentgen Ray Society, April 30-May 5, 1995 Washington, DC.)

76. SCATLIFF JH, GREEN JJ, SUZUKI K, KWOCK L, CHANCELLOR K, CASTILLO

M, SMITH JK. Postmortem MRI of lobar infarctions with pathological correlation. Radiology 193(P):455, 1994

77. GREEN C, CASTILLO M, KWOCK L, WILSON D, SMITH JK, SCHIRO S,

GREENWOOD R. New observations in patients with neurofibromatosis using H-MR spectroscopy. Fax 1994; 9:68

78. SMITH JK, CASTILLO M. Developmental malformations of the cerebellar vermis:

Diagnosis based on the midline sagittal T1-weighted MR image. AJR American Journal of Roentgenology 162(S):267 1994. (Presented at the annual American Roentgen Ray Society meeting, April 24-29, 1994, New Orleans, Louisiana.)

79. SMITH JK, MERTEN DF, CASTILLO M. Imaging of the central nervous system in

child abuse: a computer aided instructional program. Radiology 193(P):392 (Computer aided instructional program presented at the annual meeting of the American Society of Emergency Radiology, April 9-13, 1994, Orlando Florida and at the annual meeting of the Radiological Society of North America, November 27-December 2, 1994, Chicago, Illinois.)

80. SMITH JK, CARSON GC, JOHNSON JD, HARRIS JH. An Approach to Fractures of

the Midface: An Interactive Tutorial. AJR American Journal of Roentgenology 160(4) supplement:144, 1993. (Presented at the annual meeting of the American Roentgen Ray Society, April 25-30, 1993, San Francisco, Ca., and at the annual meeting of the American Society of Emergency Radiology April, 1993, San Diego, California.)

81. EFTEKHARI F, SMITH JK. Sonography of the scrotum after orchiectomy: Normal and

abnormal findings. AJR American Journal of Roentgenology 160(4) supplement:148, 1993. (Abstract presented at the annual meeting of the American Roentgen Ray Society, April 25-30, 1993, San Francisco, California.)



82. CARDEN DL, SMITH JK, KORTHUIS RJ. Role of xanthine oxidase and reactive oxygen metabolites in the genesis of microvascular dysfunction induced by activated granulocytes in skeletal muscle. FASEB J. 4(3):A642, 1990.

83. SADASIVAN KK, MOORE MB, CARDEN DL, SMITH JK, KORTHUIS RJ.

Increased microvascular permeability in an ex-vivo model of skeletal muscle compartment syndrome. FASEB J. 3(4):A273, 1989.

84. KORTHUIS RJ, SMITH JK, CARDEN DL. Is xanthine oxidase a major source of

reactive oxygen metabolites in postischemic canine gracilis muscle? Circulation, 1989.

85. CARDEN DL, SMITH JK, KORTHUIS RJ. Neutrophil adherence to microvascular endothelium: a prerequisite for neutrophil mediated microvascular injury. Circulation, 80(4) Supplement II: 400;1989.

86. CARDEN DL, SMITH JK, KORTHUIS RJ. Neutrophil-mediated microvascular injury

in the absence of tissue xanthine oxidase. FASEB J. 3(4):A1233, 1989.

87. SMITH JK, CARDEN DL, KORTHUIS RJ. Xanthine oxidase and microvascular dysfunction produced by activated granulocytes. Circulation, 80(4) Supplement II: 33; 1989. (Abstract presented at the annual American Heart Association meeting, November 13-16, 1989, New Orleans, Louisiana.)

88. SMITH JK, CARDEN DL, SADASIVAN KK, KORTHUIS RJ. Role of xanthine

oxidase in postischemic microvascular injury. FASEB J. 3(4):A1401, 1989. (Abstract presented at the annual FASEB meeting, March, 1989, New Orleans, Louisiana.)

89. SMITH JK, CARDEN DL, KORTHUIS RJ. Role of hydroxyl radicals in

ischemia/reperfusion-induced injury to skeletal muscle microvasculature. FASEB J. 3(4):A1234; 1989. (Abstract presented at the annual FASEB meeting, March, 1989, New Orleans, Louisiana.)

90. LAUGHLIN MH, SIMPSON T, SMITH JK, BROWN OR, SEXTON WL, KORTHUIS

RJ. Relationship between oxidative capacity and antioxidant enzyme levels in skeletal muscles. Physiologist 31(4):A39-A39, 1988.

91. KORTHUIS RJ, SMITH JK, CARDEN DL, GRISHAM MB, GRANGER DN. Vascular

injury from oxygen radicals and granulocytes in post-ischemic skeletal muscle. Int J Microcirc Clin Exp sup:S116-S116, 1988.

92. CARDEN DL, SMITH JK, KORTHUIS RJ. Neutrophil mediated injury to the skeletal

muscle microvasculature in the absence of ischemia. Physiologist 31(4):A30, 1988.

93. KORTHUIS RJ, SMITH JK, CARDEN DL. Limiting oxygen availability at reperfusion attenuates microvascular injury in postischemic skeletal muscle. Physiologist 31(4):A31-A31, 1988.



94. SMITH JK, YRLE LF, BENOIT JN, GRANGER DN, KORTHUIS RJ. Role of glucagon in the intestinal hyperemia associated with experimental diabetes mellitus. FASEB J. 2:A741-A741, 1988. (Abstract presented at the annual FASEB meeting May, 1988 Las Vegas, Nevada.)

95. SMITH JK, GRISHAM MB, GRANGER DN, KORTHUIS RJ. Alterations in free

radical defense mechanisms and neutrophil infiltration in post-ischemic canine skeletal muscle. (Presented at The Second Conference on Free Radicals in Biology and Medicine: Ischemia/Reperfusion Injury. March 1988, Point Clear, Alabama.)

96. SMITH JK, CARDEN DL, GRISHAM MB, GRANGER DN, KORTHUIS RJ. Role of

iron in ischemia/reperfusion injury to skeletal muscle microvasculature. Physiologist 31(4):A31-A31, 1988. (Abstract presented at the annual American Physiology Society meeting October, 1988, Montreal, Canada.)

Letters to the Editor:

1. SMITH JK, CASTILLO M. Ruptured aneurysm presenting with a subdural hematoma. AJNR:Am J Neuroradiol 165:491-492, 1995.

2. SMITH JK, CASTILLO M. Carotid sinus syndrome secondary to iatrogenic dissection of

the carotid artery. AJNR:Am J Neuroradiol 15:193, 1994. Book Reviews:

1. SMITH JK Cerebral MR perfusion Imaging: Principles and Current Applications A. Gregory Sorensen Peter Reimer in Academic Radiology 2001.

2. SMITH JK Brain Atlas for Functional Imaging: Clinical and Research Applications

Nowinski, Thirunavuukarasuu, Kennedy (Eds) in Academic Radiology :924, 2001.

3. SMITH JK. Pediatric Neuroimaging. Barkovich (Ed) in: Academic Radiology 7(10) 878, 2000.

4. SMITH JK. MRI of the spine. St. Amour, Hodges, Laakman, Tamas (Eds) in: Topics in

Magnetic Resonance Imaging ,6(4):275;1994.

5. SMITH JK. MR angiography: A teaching file. Brant-Zawadski, Boyko, Jensen, Gillian (Eds) in: Topics in Magnetic Resonance Imaging 6(3):203;1994.



TEACHING RECORD: Undergraduate students:

Lauren Brubaker: Biology Honors Thesis research sponsor for undergraduate student at high field MRI research center: The Use of MRI Imaging to Evaluate Twitcher Mouse Syndrome, UNC Spring Semester 2002

Derek Cool: Mentor for undergraduate research project: Circulatory changes in cerebral perfusion resulting from HIV associated dementia. UNC 2003

Medical students:

Block 7 Neurosciences UNC 2nd year medical students lecturer and lab preceptor. Introduction to neuroimaging and developmental and congenital malformations of the CNS lectures, Assisted in development of labs and syllabi for neuropathology portions of course. 2004-2015

Block 11 Clinical Medicine Cases UNC 2nd year medical students lab preceptor for neuroimaging in acute stroke. 2003-2015

Introduction to Radiology Course UNC 1st year medical school class, 2003-present: lab preceptor.

Radiology 411 Research Elective-Preceptor for medical students: Christopher Looney (Doris Duke Fellow 2004-2005)

Anup Parikh (Doris Duke Fellow 2003-2004) Jackson Hamilton (Doris Duke Fellow 2002-2003)

Matt Dyson (UNC Medical Student 2003) Rihan Khan (Dartmouth Medical School Student, 2002) Radiology Elective 404 Clinical Neuroscience Selective: Preceptor to senior

medical students in neuroradiology UNC 1999-present Neuropathology section of second year medical school Pathology and Laboratory

Medicine 222 class UNC 1999-2004. This includes course and syllabus development, lab preceptoring, and lectures.

Human physiology course, endocrine section, 50 students Louisiana State University Medical Center, Shreveport, Louisiana 1987-89.

Graduate students:

Weekly journal club for high field MRI research students, UNC, 2000-present Thesis Committee Member for graduate students at MRI research center: Wei Gao: PHD candidate UNC BME department, 2007-2011. Qingwei Liu: PHD candidate UNC BME department, 2006-present. Guihua Zhai: PHD candidate UNC BME department, 2002-2006.

Yueh Lee: MD/PhD candidate UNC BME department, 2001-2004. Hui Liu: Masters candidate UNC BME department, 2002-2004.



Residents:

Residency Program director UNC Department Of Radiology Diagnostic Radiology- (2007-2011) resident complement 32, 4 year program

Daily training of radiology residents in the Neuroradiology Section Supervision of Neuroradiology Residents presenting biweekly Radiology

Department Conference, Hot Seat conference, Board Review Conferences Supervision of Neurology and Neurosurgery Residents performing neuroradiology

elective Training and supervision of radiology residents from the Medical University of

South Carolina (2001-2002) Psychiatry Residents: Lecturer in the Neuropsychiatry Seminars, Didactic

conference series: Neuroimaging Basics with Focus on CT/MRI 2004-2014

Neuroradiology fellows:

Daily training of fellows (1-4/year) in Neuroradiology Section Fellows trained (and current location): 1. Jeffrey A. Stone, M.D. (Mayo Clinic, Jacksonville, FL) 2. Andrés Arbeláez-Medina, M.D. (Medellin, Colombia) 3. Allan Midyett, M.D. (Brooke Army Med. Ctr. San Antonio, TX) 4. Decio Kruter, M.D. (Porto Alegre, Brasil) 5. Sonia Palma, M.D. (Guatemala, Guatemala) 6. Michael Clark, M.D. (Ohio) 7. Todd Smith, M.D. (Little Rock, Arkansas) 8. Zoran Rumboldt, M.D. (Croatia) 9. José Costa (Porto, Portugal) 10. Hugo Narcisco (San Pablo, Brazil) 11. Mónica Pedro (Curitiba, Brazil) 12. Ana Londoño (Medellin, Colombia) 13. Gisele Matheus (Medical Univ. of South Carolina, Charleston, SC) 14. Gurav Kumar (Missouri) 15. José Negrón-Soto (Ohio State Univ., Columbus, Ohio) 16. Kenneth Lury (University of North Carolina, Chapel Hill, NC) 17. Ayotunde Ogunseyinde (Laos, Nigeria) 18. Woo Mok Byum (Daegu, Korea) 19. Christopher Van der Meer (Gaston Radiology, Gastonia, NC) 20. Jay Alley (Rex Hospital, Raleigh, NC) 21. Carla Maria Gonzales (Quetzaltenango, Guatemala) 22. John Grimme (Eugene, Oregon) 23. Daniel Camacho (Milwaukee, Wisconsin) 24. Vittoria Spampinato (Medical Univ. of South Carolina, Charleston, SC) 25. Nuria Mayolas (Barcelona, Spain) 26. Fabiana Brito (Rio de Janeiro, Brazil) 27. Fernando Detoni (Blumenau, Brazil) 28. Steven Olijeski (Erie, Pennsylvania) 29. Thomas Marino (Fort Lauderdale, Florida) 30. Ben Huang (University of North Carolina, Chapel Hill, NC)



31. Arturo Alvarez-Luque (Madrid, Spain) 32. Maria Pilar Valencia (Univ. Texas, San Antonio, Tx) 33. Humberto Morales (Univ. Cincinnati, Ohio) 34. Craig Harr (Eugene, Oregon) 35. Carter Kenamond (Chester, West Virginia) 36. Craig Roberto (Fort Lauderdale, Florida) 37. Assem Mansour (Amman, Jordan) 38. Birsen Unal (Ankara, Turkey) 39. David Bañuelos (Guadalajara, Mexico) 40. Joanna Ramalho (Lisbon, Portugal) 41. Naser Aldossary (Riyad, Saudi Arabia) 42. Marta Martinez (Madrid, Spain) 43. Michael Hollingshead (Rex Hospital, Raleigh, NC) 44. Frank Castellano (Ohio) 45. Jason Pulnik (Houston, Tx) 46. Eldom Toh (Taiwan, China) 47. Carina Reis (Porto, Portugal) 48. Ronaldo Lessa (Belo Horizonte, Brazil) 49. David Chaky (Columbus, OH) 50. Cade Martin (Little Rock, Arkansas) 51. Jeffrey Troy (Alexandria, VA) 52. Marcela Posada (Medellin, Colombia) 53. Sasitorn Petcharunpaisan (Thailand) 54. Kremer Nicholas (Little Rock, AK) 55. Brooks Taber (Durham, NC) 56. Ali Nassim (Fayetteville, NC) 57. Angel Sanchez (Barcelona, Spain) 58. Claudia Glaussius (Montevideo, Uruguay) 59. Arvemas Watcharakorn (Thailand) 60. Catalina Vargas (Bogota, Colombia) 61. Aaron Vidal Tellez (Chile) 62. Barbara Suarez (Spain) 63. Adriana Caldera (Spain) 64. Debora Bertholdo (Brazil) 65. Aracely Matos (Spain) 66. Mike Solle (Durham, NC) 67. Janica Walden (Statesboro, GA) 68. Patrick Farley (Univ. Missisipi, MS) 69. Aaron Vidal Tellez (Chile) 70. Margareth Kimura (Brazil) 71. Ana Maria Granados (Colombia) 72. Juan Camilo Marquez (Colombia) 73. Susie Muir (Teleradiology services) 74. Yueh Lee (University of North Carolina, Chapel Hill, NC) 75. Sara Safder (Orlando, FL) 76. Khurram Javed (Tampa, FL) 77. Ahmad Al Zoubi (Saudi Arabia) 78. Francisco Medina Valencia (Colombia) 79. Adriana Pajon (Colombia) 80. Carina Vallejo (Caracas, Venezuela)



81. Alberto Pla (Barcelona, Spain) 82. Victor Perez (Barcelona, Spain) 83. Cesar Rodriguez (Bogota, Colombia) 84. Stephen Bagg (Charleston, SC) 85. Felipe Espinoza (Miami, FL) 86. Joshua Gibson (Huntington, WV) 87. Ray Peeples (Little Rock, AK) 88. Rafael Alvarez (Guatemala, Guatemala) 89. Billal Battal (Istambul, Turkey) 90. Sofia Pina (Porto, Portugal) 91. Miguel Lemus Rosales (Barcelona, Spain) 92. Noelia Silva (Vigo, Spain) 93. Francisco Chiang (Santiago, Chile) 94. Hatsuho Crane (Boston, MA)* 95. Joel Marquess (Fairbanks, Alaska)* 96. Ben McClintock (Hawaii)* 97. Rama Sharma (University of Pennsylavania, Philadelphia)* 98. Gustavo Tedesqui (Sao Pablo, Brazil) 99. Theeraphol Panyaping (Bangkok, Thailand) 100. Paulo Puac (Guatemala, Guatemala) 101. Gerardo Pacheco (Lima, Peru) 102. Michael Simons (Panama City, Panama) 103. Daniel Varon (Cali, Colombia) 104. Amanda Moraes (Curitiba, Brazil) 105. Amelia Orihuela (La Coruña, Spain) 106. Jose Paulo Martinez (Granada, Spain) 107. Erik Wanderly (Blumenau, Brazil) 108. Rocio Contreras (Granollers, Spain) 109. Kenny Rentas (UNC MSK fellow)* 110. Erin Hamilton (West Virgina)* 111. Prashant Shankar (Atlanta, Georgia)* 112. Melissa Davis (Yale University, New Haven)* 113. Ana Lorena Abello (Cali, Colombia) 114. Renato Nunez Hoffman (San Pablo, Brazil) 115. Lea Klein (Spain/Luxembourg) 116. Mauricio Morena (Bogota, Colombia) 117. Natali Angulo (Lima, Peru) 118. Tito Navarro (Lima, Peru) 119. Juan Manual Gonzalez (Colombia) 120. Jaime Isern (Barcelona, Spain) 121. Mariana Salazar (Lima, Peru) 122. Marcos Camargo (Sao Pablo, Brazil) 123. Ana Morales (Guatemala) 124. Christopher Karakasis * 125. Matt Lopez * 126. Kwaku Obeng * 127. Shaun Wagner * 128. Francisco Sepulveda (Buenos Aires, Argentina) 129. Romy Ames (Lima, Peru) 130. Monika Amunugama (Sri Lanka)



131. Alex Hung (Tapei, Taiwan) 132. Segundo Cabrare (Lima, Peru) 133. Alex Hung (Taipei, Taiwan) 134. Monika Amunuga (Sri Lanka) 135. Monica Orgaz Alvarez (Madrid, Spain) 136. Suely Fazio (San Paulo, Brazil)

Interdepartmental conferences:

Weekly Neuropathology Conference Weekly Neuro-oncology Conference Clinical Pathology Conference March 14, 2000 Clinical Pathology Conference December 19, 2000 Clinical Pathology Conference July 24, 2001 Clinical Pathology Conference April 23, 2002 Neurology Department Grand Rounds August 13, 2003 Neurology Department Grand Rounds July 14, 2004 Invited teaching lectures:

Just say “No” to SATCHMO Invited Lecturer, University of Virginia, Department of Radiology, 2014, and University of Alabama, Birmingham, Department of Radiology, 2011, and Louisiana State University, Department of Radiology, 2009 Perfusion, Diffusion, and BOLD MRI Invited Lecturer, Louisiana State University Medical Center, Department of Physiology, 2009 Nurosarcoidosis Invited Lecturer, Louisiana State University Medical Center, Department of Neurosurgery, 2009 State Of The Art Imaging Of Neurosarcoidosis Part of the Clinical Categorical Course on Imaging CNS Autoimmune Diseases at The International Society for Magnetic Resonance in Medicine annual meeting in Toronto, Ontario, Canada. May 7, 2008. Pediatric Brain Imaging- Is it Normal or Child Abuse Lecture: North Carolina Radiology Society Annual Meeting, April 12, 2008 Chapel Hill, North Carolina Diagnosis and Management of Meningitis, department of medicine grand rounds University of North Carolina at Chapel Hill School of Medicine, June 2008 Neuroradiology After Five Lecture: North Carolina Chapter of the ACR Annual Meeting, October 15, 2005 Greensboro, North Carolina Neuroanatomy for Neuroimaging Lecture: UNC Psychiatry Department Core Imaging Lab seminar series October 4, 2005



Imaging of Spinal Cord Injury and Low Back Pain Lecture: UNC Department of Rehabilitation Medicine Seminar Series June 1, 2005 Normal Brain Anatomy. Lecture: UNC Medical Image Display & Analysis Research Group (MIDAG) seminar series December 2004 Multidisciplinary Evaluation for Surgical Treatment of Epilepsy Pediatric Grand Rounds, UNC Department of Pediatrics October 7, 2004 Single and Multivolume MR Spectroscopy of Brain Tumors. Part of the Categorical Course on Oncologic Imaging: American Roentgen Ray Society 2003 Annual Meeting May 4-9, 2003 San Diego, CA Clinical aspects of diffusion and perfusion MR imaging. Siemens applications specialist training course. July 11, 2000, Cary, North Carolina Medical Imaging Modalities. UNC Computer-Aided Diagnosis and Display Lab October, 9, 2000.

Educational Media: 1. Imaging developmental venous anomalies with atypical features. Address:

http://www.neurographics.org Castillo M, Smith JK. 2. An Approach to Fractures of the Midface: An Interactive Multimedia Teaching

Program. Produced by JK Smith, GC Carson, and JH Harris. 3. Imaging of the central nervous system in child abuse: a computer aided instructional

program. Produced by JK Smith, D Merten, and M Castillo.

4. Imaging of Central Nervous System Neoplasms in Children: a computer aided instructional program. Produced by T Noone, M Castillo, and JK Smith.

5. Internet Accessible Radiology Teaching File: Produced by JK Smith.

6. Imaging of Central Nervous System Hemorrhage: a computer aided instructional program. Produced by JE Thompson, M Castillo, and JK Smith.

7. Imaging of central nervous system congenital malformations with pathologic correlation: a computer-aided instructional program. Produced by JK Smith, DM Armao, and M Castillo



RESEARCH (ACTIVE 40%):

2R01HD053000-07 (PI:Gilmore, J) 9/1/13-8/30/18 0.22 Cal Months (2%) NIH $397,873 Early Brain Development in one and two Year Olds Role: Investigator 5-33977 We will extend follow-up of our cohort to 6 years of age and focus on structure/function relationships and the predictive value of early brain structure for later childhood brain structure and cognitive function. 1R01MH100217-03 (PI:Shen, D.) 8/26/13-5/31/17 0.46 Cal Months (3.8%) NIH $333,102 Infant Brain Measurement and Super-Resolution Atlas Construction Role: Investigator 5-33610 This project shoulders the challenging task of overcoming important technological hurdles in creating high precision computational tools that will automate the quantification of brain development in the first year of life. 2R01AG041721-04 (PI:Shen, D) 9/1/12 – 3/31/20 0.18 Cal Months (2%) NIH $240,589 Quantifying Brain Abnormality by Multimodality Neuroimage Analysis Role: Investigator 5-32916 The goal of this project is to develop a novel neuroimaging analysis framework that will harness the complementary information from different imaging modalities for effective quantification of disease-induced pathologies, so as to promote early detection for possible treatment and prophylaxis.

5R01EB009634-04 (PI:Shen, D) 9/1/11 – 8/31/16 0.12 Cal Months (1%) NIH $0 NCE Fast, Robust Analysis of Large Population Data Role: Investigator 5-31491 This project aims at development, testing, and evaluation of fast, robust, and accurate group registration and statistical comparison algorithms for effective processing of large sets of brain images simultaneously, thus enabling the detection of tiny, complex group differences. 5R01HD059854-05 (PI:Hazlett, H) 9/30/09-12/31/15 0.30 Cal Months (3%) NICHD $0 NCE A Longitudinal MRI Study of Brain Development in Fragile X Syndrome Role: Investigator 5-33086 This study will examine how the trajectory and growth of brain development in infants with FXS compares to early brain development in infants (at high-risk for autism) who later develop an autism spectrum disorder and in infants with typical brain development.



5R01HD055741-09 (Piven, J) 7/1/07 – 5/31/17 0.36 Cal Months (3%) NICHHD $2,181,634 A Longitudinal MRI Study of Infants at Risk for Autism-UNC Site This proposal focuses on the utilization of novel MR imaging methods, including structural and diffusion tensor imaging approaches to depict brain abnormalities in infants at risk of autism. R01MH064708-08 (Reiss-Stanford PI) 9/4/12 – 5/31/16 0.60 Cal Months (5%) 60091569-24813-A (UNC PI-Piven, J) $199,644 Stanford University/NIMH Longitudinal MRI Study of Brain Development in Fragile X This competitive renewal of a longitudinal study of brain and behavioral development in young boys with Fragile X Syndrome (FXS) proposes continuation of a successful, collaborative study conducted by research teams at Stanford University (PI: Allan Reiss) and the University of North Carolina (PI: Joe Piven). FXS is an etiologically homogeneous developmental disorder and the most common single gene disorder associated with autistic behavior.

5R01EB006733-06 (PI:Shen, D) 9/17/08 - 8/31/16 0.4 Cal Months (3%) NIBIB $367,223 Development and Dissemination of Robust Brain MRI Measurement Tools Role: Investigator 5-33170 The goal of this project is to develop and widely distribute a software package for robust measurement of brain structure in MR images by using computational neuroanatomy methods. *1R21-MH104330-02 (Santelli, R.) 8/26/13-7/31/17 0.36 Cal Months (3%) NIH $167,447 Gut Microbiota and Anxiety: A Mechanistic Study of Human Infants This is the first study to test if and how microbial composition relates to anxious behavior in a human cohort. The research is significant in that it is an essential first-step in developing novel interventions to promote a healthy microbiome and reduce risk for psychiatric illness. *2R01EB008374-05 (Shen, D.) 5/1/15-4/30/19 0.60 Cal Months (5%) NIBIB/NIH $316,037 4D Software Tools for Longitudinal Prediction of Brain Disease The goal of this renewal project is to create a set of innovative 4D software tools that are dedicated to more effective early diagnosis and prediction of brain disorders with longitudinal data. These tools will allow elucidating subtle abnormal changes that would be otherwise left undetected with existing tools.



*2-U01-MH070890-11A2 (Gilmore, J) 7/1/15 – 6/30/20 0.60 Cal Months (5%) NIMH / NIH $519,058 Early Brain Development in Twins Study normal brain development by comparing similarities of brain structure and development between twins to better understand the contributions of genes and environmental factors.

RESEARCH (PENDING):

P01 (Johns, J) 7/1/15-6/30/20 0.60 Cal Months (5%) NIH/NIDA $1,873,350 Cocaine's Effects on Mothers and Offspring: Translational Mechanisms (Project 2-PI-Grewen) Study the effects of cocaine on the mother-offspring diyad.

RESEARCH (COMPLETED, SELECTED):

5R01HD055741-06S1 (PI:Piven, J) 6/1/14 – 5/31/15 0.96 Cal Months NICHD $2,422,378 Percent Effort: 8% A Longitudinal MRI Study of Infants at Risk for Autism-ACE Network Role: Investigator 5-33188 This proposal focuses on the utilization of novel MR imaging methods, including structural and diffusion tensor imaging approaches to depict brain abnormalities in infants at risk of autism. 2R01MH070890-08 (PI:Gilmore, J) 12/1/09 – 11/30/14 0.60 Cal Months NIMH / NIH $471,221 Percent Effort: 5% Early Brain Development in Twins Role: Investigator 5-30664 Study normal brain development by comparing similarities of brain structure and development between twins to better understand the contributions of genes and environmental factors. 5R01NS055754-05 (PI:Lin, W) 5/1/07 – 4/30/13 0.60 Cal Months NIH/NINDS $396,011 Percent Effort: 5% Characterization of Normal Brain Development Using Parallel MRI Role: Investigator 5-34816 This study focuses on developing both hardware and software for imaging normal pediatric subjects. 5P50MH064065-10 (PI:Gilmore, J) 7/01/01 - 7/31/13 0.60 Cal Months NIMH/NIH $1,429,311 Percent Effort: 5% Prospective Studies of the Pathogenesis of Schizophrenia: Project 1 Role: Investigator 5-51130 Determine how fetal and neonatal ventricle size obtained with ultrasound is related to a more detailed assessment of brain structure and function obtained with MRI. 5R01HD053000-05 (PI:Gilmore, J) 3/1/07 – 2/29/13 0.30 Cal Months

https://commons.era.nih.gov/commons/genericStatus.do?actionRole=nonPI&applID=7876227&uhf-token=I2AZye%2BkOnuYP8XWtzCbp0NS%2Fgg%3D



NIH $141,120 Percent Effort: 3% Early Brain Development in One and Two Year Olds Role: Investigator 5-34811 This study will longitudinally image pediatric subjects at 1 and 2 years old in order to depict normal brain development. 1R01HD059854-01A1 (PI:Hazlett, H)7/1/09 – 6/30/14 0.60 Cal Months NIH $587,073 Percent Effort: 5% A Longitudinal MRI Study of Brain Development in Fragile X Syndrome Role: Investigator 5-30367 This study will examine how the trajectory and growth of brain development in infants with FXS will compare to early brain development in infants at high-risk for autism (and who later develop ASD) as well as typical brain development. 1RC1MH088520-01 (PI:Shen, D) 9/30/09 – 9/29/11 0.60 Cal Months NIMH – ARRA $500,000 Percent Effort: 5% Neonatal Brain Segmentation Role: Investigator 5-30281 Existing segmentation algorithms developed for adult or even pediatric brain images fail to segment neonatal brain images satisfactorily. We propose to address this challenging issue by developing a novel neonatal segmentation method by taking advantage of the unique longitudinal datasets acquired in UNC-CH’s four NIH-funded projects. NOCSAE (PI:Guskiewicz, K) 3/1/09 – 9/30/11 0.36 Cal Months

$125,614 Percent Effort: 3% Prospective Investigation of Sport-Related Concussion: Relationship between Biomechanical, Neuroanatomical, and Clinical Factors Role: Investigator 5-49643 The uniqueness of this research proposal is the capacity to measure the biomechanical, neuroanatomical, and clinical factors associated with cerebral concussion. Foundation of Hope (PI:Hazlett, H) 6/3/09 – 6/30/12 0.12 Cal Months Foundation of Hope $40,000 Percent Effort: 1% A Pilot Study of Brain Development In Infants with Down Syndrome Role: Investigator 5-47524 This study will track brain development in infants with Down Syndrome using MRI/DTI scans. Children with Down Syndrome (DS) will be scanned using MRI at 6, 12, and 24 months of age. Autism Speaks (PI:Hazlett, H) 2/1/08 – 1/31/11 0.36 Cal Months Autism Speaks $449,226 Percent Effort: 3% MRI study of brain development in school age children with autism Role: Investigator 5-45056 This proposal would track brain development using MRI/DTI scans in 6-10 year olds with autism and controls who have already participated in a longitudinal MRI study of brain development.

2/15/97 – 6/30/10: NIBIB/NIH (5 R01 EB000219-11) 3D vessel location for surgical planning, PI: E. Bullitt. (10% effort) Total direct cost: $332,972.

https://commons.era.nih.gov/commons/genericStatus.do?actionRole=nonPI&applID=7819885&uhf-token=N01i9gZLHKjs15Ts96IsbzFZsqU%3D



8/1/02-7/31/07: IMH (1 P50 MH064065-01) UNC Conte Center Project 2: Early Brain Development in High Risk Children, PI: J.H. Gilmore. (5% effort) Total direct cost: $1,296,320.

6/1/03-5/31/04: UNC Center for Aids Research Development Award: Diffusion Tensor Imaging for Evaluation of White Matter Changes in HIV Related Cognitive Impairment. PI: J. Keith Smith, MD, PhD (no salary support) Total direct cost: $20,000.

4/1/97-3/31/04: NIMH (RO1 MH55466) “Neuroimaging in HIV Infection”. Co-investigator (5% effort) (Principal Investigator Colin D. Hall). Annual direct cost: $150,000.

10/1/02-9/30/03: UNC Clinical Nutrition Research Center pilot and feasibility grant “Memory function in subjects undergoing choline depletion” (no salary support) Total direct cost: $15,000.

4/1/01-3/31/06: NIH-NCI (R01CA67812) "3D vessel location for surgical planning" Co-investigator, 10% effort (Principle Investigator Elizabeth Bullitt) Annual direct cost: $364,000.

9/1/87-6/30/89: NIH-Individual National Research Service Award (HL-07710) Microcirculatory response to ischemia-reperfusion,. J. Keith Smith, Principle Investigator (100% effort), Ronald J. Korthuis, sponsor. Total direct cost: $30,000.

CLINICAL TRIALS (SELECTED): (active trials can be accessed in IRBIS and ONCORE systems)

2005 – 2008: SENTIS Stroke Trial Protocol: Safety and Efficacy of NeuroFlo Technology

in Ischemic Stroke with SCION (A Study of Care Intensity and Outcomes of NeuroFlo). Co-investigator, PI: Souvik Sen

2004 – 2007: A Double-blind, Randomized, Placebo-controlled, Parallel-group,

Multicenter, phase 11b/111 Study to Assess the Efficacy and Safety of Intravenous NXY-059 in Acute Ischemic Stroke (SA-NXY-0007). Co-investigator, PI: Souvik Sen

2004 – 2007: Silent Cerebral Infarct in Sickle Cell Disease Multi-Center Clinical Trial

(SIT). Co-investigator, PI: Rupert-Lalenger 2004 – 2007: Neuropsychololgical Dysfunction and Neuroimaging Abnormalities in

Neurologically Intact Adult Patients With Sickle Cell Disease (CSCC). Co-investigator, PI: Eugene Orringer

2004 – 2007: LCCC 0409: Treatment Of Brain Metastases From Non-Small Cell Lung

Cancer With Concurrent Whole Brain Radiation Therapy And Pemetrexed Co-investigator, PI: Tom Stinchcombe

2004 – 2007: The Interventional Management of Stroke (IMS III) Trial. A randomized,

open-label multi-center study that will examine whether a combined intravenous (IV) and intra-arterial (IA) approach to recanalization is



superior to standard IV t-PA alone when initiated within three hours of stroke onset. Co-investigator, UNC PI: Souvik Sen

2004-2006: SAINT NXY-089 in Acute Stroke. A randomized, placebo-controlled,

international, neuroprotective trial in acute ischemic stroke, sponsored by Astra-Zeneca. Co-investigator, PI: Ana Felix

2004-2007: Intravenous Vs Intra-arterial tPA (Activase) In Acute Ischemic Stroke With

CT Angiogram Evidence Of Major Vessel Occlusion. Co-investigator: Investigator-initiated study PI: Souvik Sen

2003-2006: Mechanical Embolus Removal in Cerebral Ischemia Trial to study "Safety

and efficacy of the MERCI retriever in the treatment of thrombotic occlusion originating in the internal carotid, middle cerebral (M1 & M2 segments), basilar or vertebral arteries". Co-investigator, PI:Sten Solander, Sponsor: Concentric Medical

2003-2006: RREACT study "A Randomized, Double-blind, Placebo-controlled, Multi

center Study of the Effects of ONO-2506 Intravenous Infusion on the Amelioration of Neurological Damage and Improvement of Stroke Assessment Scale Scores in Patients with Acute Ischemic Stroke" Co-investigator, PI: Souvik Sen Sponsor: ONO

2003-2007: mRECT study "A Randomized, Double-Blind, Placebo-Controlled Trial to

Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetic/Pharmacodynamic Effects of a Targeted Exposure of Intravenous Repinotan HCl in Patients with Acute Ischemic Stroke (Modified RECT)." Co-investigator, PI: Souvik Sen, Sponsor: Bayer

2003-2006: Phase III Multicenter Study of Intratumoral/Interstitial Therapy with

TransMID Compared to Best Standard of Care in patients with Progressive and/or Recurrent Non-resectable Glioblastoma Multiforme. Co-investigator, PI: Mathew Ewend

2001-2003: Phase II Study Utilizing the Gliasite RTS for the Treatment of a Resected

Solitary Brain Metastasis. Co-investigator, PI: Mathew Ewend 1999-2000: Phase III Randomized Study of SU101 versus Procarbazine for Patients

with Glioblastoma Multiforme in First Relapse Co-investigator, PI: Mathew Ewend

1998-2000: Phase II Open Labeled Study of SU101 for Patients with Anaplastic

Astrocytoma in First Relapse. Co-investigator, PI: Mathew Ewend 1997-2000: Phase II Trial of Surgery with Gliadel Wafer and Radiation in patients with

Operable CNS Metastasis from Systemic Cancer. Co-investigator, PI: Mathew Ewend

1995-1998: Treatment of Anaplastic Gliomas with Concomitant Intra-arterial Cisplatin

and Radiotherapy. Co-investigator, PI: Keith Quatroci



PROFESSIONAL SERVICE: UNIVERSITY OF NORTH CAROLINA COMMITTEES:

UNC Healthcare Carolina Value Patient Access Committee (Ad Hoc member) 2015-Present UNC Epic Physician Informatics Council (ePIC) member 2013-Present UNC Healthcare Epic Radiology Department Physician Liaison 2013-Present UNC Healthcare Epic Radiology Super-user 2013-Present UNC School of Medicine Faculty Post Tenure Review Committee member

2013-2014 UNC Cancer Protocol Review Committee (PRC) member 2011-Present UNC Department of Radiology Outreach Committee member 2011-2014 UNC BRIC (Biomedical Imaging Research Center) executive committee member 2011-Present UNC Department of Radiology Executive Committee member 2011-Present UNC School of Medicine Academy of Educators - elected 2011. Membership is

an honor and recognition of teaching excellence and dedication to the education mission of the School of Medicine.

UNC School of Medicine Associate Professor Faculty Promotion Review Committee member 2009-2013

Committee Chair 2012-2013 Radiology representative and member of the steering committee to The University

of North Carolina enterprise wide Radiology Information System committee 2005-2013

Review Committee member for The UNC Injury Prevention Research Center’s annual Susan P. Baker Student Research Paper Prize, 2004-Present

Member, Multidisciplinary Neuro-oncology Program, UNC Lineberger Comprehensive Cancer Center 1999-Present

Radiology representative and member of the steering committee to The University of North Carolina enterprise wide PACS committee 1999-2012

Radiology Department Residency Selection Committee, 2001-2013 Member of the multidisciplinary team for intrauterine evaluation and treatment of

open neural tube defects 2000-2002 Clinical Associate director for high field MR imaging research, UNC Department

of Radiology 2000-2011



EDITORIAL POSITIONS

American Journal of Neuroradiology, Editorial Board Member 2009-present

Reviewer, 1999-present American Journal of Roentgenology,

Reviewer 1999-present Transactions on Medical Imaging, Reviewer 2003-present Clinical Neuropharmacology Reviewer 2008-present Ophthalmic Plastic and Reconstructive Surgery Reviewer 2010-present

Applied Magnetic Resonance Reviewer 2010-present PROFESSIONAL SOCIETIES:

American Society of Neuroradiology American College of Radiology Radiology Society of North America American Society of Pediatric Neuroradiology International Society of Magnetic Resonance Imaging in Medicine (ISMRM) American Society of Emergency Radiology American Heart Association Stroke Council American Physiological Society North Carolina Medical Association Lee County Medical Association

SERVICE TO PROFESSIONAL SOCIETIES: American Society of Neuroradiology Research Committee Member- responsible for fostering

research in neuroradiology, for overseeing researchers and research activities funded by or through the Society

National Athletic Trainers’ Association (NATA) Research and Education Foundation Research grant reviewer

PROFESSIONAL DEVELOPMENT: AUR-AGFA Radiology Management Program 2012 Participant- this program includes

training on management, human resources, leadership, business and ethical issues with a focus on mid and senior leadership positions in radiology clinical departments.

Clinical Trial Investigator Series 2012 Participant- this is an educational program provided by the UNC Center For Faculty Excellence, NC-TraCS, Office of Clinical Trials, and Lineberger Comprehensive Cancer Canter that covers all aspects of conducting clinical trials involving drugs or devices.

RSNA Creating and Optimizing the Research Enterprise Workshop 2011 Participant- this is an educational workshop sponsored by RSNA to promote development of research in Radiology Clinical Departments



New Principal Investigator Training 2011 Participant- this is an educational program provided by the UNC Center For Faculty Excellence, Office of Sponsored research, and Research Compliance Program that covers ethical, safety, and compliance issues surrounding performance of research.

UNC School of Medicine Mid Career Leadership Initiative 2010, Participant- this is an educational program provided by the UNC School of Medicine that includes training on leadership, management, and ethical issues.

UNC Teaching Scholars Program 2007-8 Participant- this development program is sponsored by the UNC office of faculty development, for individuals who have responsibility for educational programs or courses, or whose work includes a focus on teaching.

Documents

Jeffrey Keith Smith, M - UNC Health · 5656 Kelley, Department of Radiology Houston, Texas 77026 (713) 636-5440. Hermann Hospital (moonlighting) The University of Texas Health Science