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CREDIT SEMINAR CREDIT SEMINAR PHARMACOLOGY PHARMACOLOGY of of SEABUCKTHORN SEABUCKTHORN ( ( Hippophae rhamnoides Hippophae rhamnoides ) ) PRESENTED BY PRESENTED BY DR. MILINDMITRA K. LONARE DR. MILINDMITRA K. LONARE (V-2002-30-13) (V-2002-30-13) DEPARTMENT OF PHARMACOLOGY & TOXICOLOGY DEPARTMENT OF PHARMACOLOGY & TOXICOLOGY COVAS, CSKHPKV, PALAMPUR-176062 (INDIA) COVAS, CSKHPKV, PALAMPUR-176062 (INDIA) DATE:29-01- DATE:29-01- 2003 2003

INTRODUCTION

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CREDIT SEMINAR PHARMACOLOGY of SEABUCKTHORN ( Hippophae rhamnoides ) PRESENTED BY DR. MILINDMITRA K. LONARE (V-2002-30-13) DEPARTMENT OF PHARMACOLOGY & TOXICOLOGY COVAS, CSKHPKV, PALAMPUR-176062 (INDIA) DATE:29-01-2003. INTRODUCTION. SEABUCKTHORN. - PowerPoint PPT Presentation

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Page 1: INTRODUCTION

CREDIT SEMINARCREDIT SEMINAR

PHARMACOLOGY PHARMACOLOGY ofof SEABUCKTHORNSEABUCKTHORN ((Hippophae Hippophae

rhamnoidesrhamnoides))

PRESENTED BYPRESENTED BY

DR. MILINDMITRA K. LONAREDR. MILINDMITRA K. LONARE(V-2002-30-13)(V-2002-30-13)

DEPARTMENT OF PHARMACOLOGY & TOXICOLOGYDEPARTMENT OF PHARMACOLOGY & TOXICOLOGYCOVAS, CSKHPKV, PALAMPUR-176062 (INDIA)COVAS, CSKHPKV, PALAMPUR-176062 (INDIA)

DATE:29-01-DATE:29-01-20032003

Page 2: INTRODUCTION
Page 3: INTRODUCTION
Page 4: INTRODUCTION

♪♪ Grows naturally in cold countries on Grows naturally in cold countries on river river sides, hill top & sun facing sides, hill top & sun facing mountainsmountains

♪♪ India- found in dry temporate HimalayasIndia- found in dry temporate Himalayas

♪♪ Himachal pradesh-found in Chamba, Himachal pradesh-found in Chamba, Kinnaur, Kinnaur, Kullu& Lahaul-SpitiKullu& Lahaul-Spiti

♪♪ It is quality fuel wood and fodderIt is quality fuel wood and fodder

♪♪ Potential health foodPotential health food

Page 5: INTRODUCTION

Historical BackgroundHistorical Background♪ ♪ First report - China (8First report - China (8th th century), In Yue century), In Yue

Wang You Zhen medicinal classic Wang You Zhen medicinal classic

♪ ♪ Second report – Tibetan & Mongolia (18Second report – Tibetan & Mongolia (18thth century), in Sibu Yidian (Tibetan classic)century), in Sibu Yidian (Tibetan classic)

♪♪ India – used locally since time India – used locally since time immemorial immemorial

♪ ♪ officially listed by Chinese officially listed by Chinese Pharmacopoeias Pharmacopoeias by ministry of public by ministry of public health (1977)health (1977)

Page 6: INTRODUCTION

Composition & FunctionsComposition & Functions

Fruit juice:Fruit juice: 60-80 %, 190 kinds of bioactive substances60-80 %, 190 kinds of bioactive substances

1.1. Organic acidsOrganic acids (malic/oxalic/unidentified (malic/oxalic/unidentified acids)acids)

- Terminating toxicity- Terminating toxicity - Protection from teratogenesis & X-ray - Protection from teratogenesis & X-ray

damagedamage - Prevention from side-effects of O- Prevention from side-effects of O22

therapytherapy

2.2. BetainesBetaines (methylation of glycine) (methylation of glycine) - prevents & cures arteriosclerosis - prevents & cures arteriosclerosis - anti-inflammatory- anti-inflammatory

Page 7: INTRODUCTION

3.3. TriterpeneTriterpene (ursolic acid) (ursolic acid)- adrenocorticotropic mimetic- adrenocorticotropic mimetic- controls action of Na- controls action of Na++ & Cl & Cl--

- anti-inflammatory activity- anti-inflammatory activity

4.4. FlavonoidsFlavonoids (flavonol, catechin, (flavonol, catechin, lukocyanidin & flavone)lukocyanidin & flavone)- prevents vit-C oxidation - prevents vit-C oxidation

- lowers cholesterol levels- lowers cholesterol levels- anti-microbial & anti-inflammatory- anti-microbial & anti-inflammatory- anti-allergic & anti-tumorogenic- anti-allergic & anti-tumorogenic

Page 8: INTRODUCTION

5.5. 5–HT5–HT (5 - hydroxytryptamine) (5 - hydroxytryptamine) - regulates B.P. and temperature- regulates B.P. and temperature - influences sleep, intestinal motility, - influences sleep, intestinal motility,

hormonal hormonal level & emotionslevel & emotions- promote coagulation- promote coagulation

6.6. ββ- amyrinoleylalcohol acid- amyrinoleylalcohol acid- dilates cardiac & cerebral vessels- dilates cardiac & cerebral vessels- facilitates blood circulation- facilitates blood circulation

7.7. CoumarinsCoumarins- strengthen capillary function- strengthen capillary function- anti-tumorogenic, anti-numbness and - anti-tumorogenic, anti-numbness and anti-pyreticanti-pyretic

Page 9: INTRODUCTION

8.8. TriterpeneTriterpene (ursolic acid) (ursolic acid)- adrenocorticotropic mimetic- adrenocorticotropic mimetic- controls action of Na- controls action of Na++ & Cl & Cl--

- anti-inflammatory activity- anti-inflammatory activity

9.9. Amino acids & MineralsAmino acids & Minerals

10.10. Flavoxanthin, cryptoxanthin and Flavoxanthin, cryptoxanthin and violaxanthinviolaxanthin

Page 10: INTRODUCTION

11.11. ProgestinProgestin

12.12. VitaminsVitamins - - ββ-carotenes (250 mg/100gm)-carotenes (250 mg/100gm) - Vit.-C, K, E- Vit.-C, K, E13.13. SteroidesSteroides (ergosterols, stigma (ergosterols, stigma

sterols, sterols, lanosterols & lanosterols & amyrins )amyrins )

14.14. Tannic acidTannic acid

15.15. Fatty acidsFatty acids

Page 11: INTRODUCTION

Seed oil:Seed oil:8-18 %, 106 bioactive substances8-18 %, 106 bioactive substances

1.1. 22 kinds of fatty acids22 kinds of fatty acids (saturated-13.7% (saturated-13.7% & unsaturated-86.3%)& unsaturated-86.3%)

- linolenic acid (omega-3 & 6)- linolenic acid (omega-3 & 6)

- oleic acid- control cholesterol level- oleic acid- control cholesterol level

- anti-diabetics, obesity & - anti-diabetics, obesity & cancercancer

- essential for fat soluble - essential for fat soluble vitaminsvitamins

Page 12: INTRODUCTION

2.2. 6 knds of fat soluble vitamins6 knds of fat soluble vitamins

- vit.A; carotene-249mg/100g- vit.A; carotene-249mg/100g

- vit.E-203mg/100g- vit.E-203mg/100g

- vit.K-150mg/100g- vit.K-150mg/100g

3.3. 36 kinds of flavonoids and phenols36 kinds of flavonoids and phenols

- anti-oxidation, anti-radiation- anti-oxidation, anti-radiation

- enhancement of cachettin & quassium - enhancement of cachettin & quassium functionsfunctions

Page 13: INTRODUCTION

4.4. 42 kinds of phospholipids42 kinds of phospholipids

- strengthen the membrane mitochondria- strengthen the membrane mitochondria

- participation in electron migration- participation in electron migration

- oxidative phosphorylation & cellular - oxidative phosphorylation & cellular metabolismmetabolism

Fruit residue:Fruit residue:- 20 % of total wt.- 20 % of total wt.

- rich in proteins, amino acids, - rich in proteins, amino acids, carotene, carotene, vitamin C (426-503 mg/100g), vitamin C (426-503 mg/100g), microelementsmicroelements

Page 14: INTRODUCTION

Nutritional valueNutritional value

PartsParts CPCP(%)(%)

EE EE (%)(%)

Ash Ash (%)(%)

CuCu

(ppm(ppm))

Zn Zn (ppm(ppm))

Fe Fe (ppm(ppm))

LeaveLeavess

28.428.4 2.82.8 11.811.8 0.200.20 39.639.6 68.468.4

BarkBark 17.817.8 2.32.3 4.74.7 1.41.4 6.46.4 183183

BrancBranchh

13.713.7 1.91.9 6.86.8 1.81.8 15.215.2 177177

Page 15: INTRODUCTION
Page 16: INTRODUCTION

Effect of fodder Effect of fodder supplementationsupplementation

AnimalAnimal SupplementationSupplementation EffectEffect

Weak Weak pigpig

Leaves Leaves Wt. gain, 9-13 %Wt. gain, 9-13 %

Goat Goat Leaves Leaves Inc. Milk, 6-7 %Inc. Milk, 6-7 %

Chicken Chicken Leaves, fruit, Leaves, fruit, seed seed

Wt. gain, 9-13 %Wt. gain, 9-13 %

Layer Layer Leaves, fruit, Leaves, fruit, seed seed

Laying cap., 26 Laying cap., 26 %%

Page 17: INTRODUCTION
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Healing potentialHealing potential Plays role in ulcer, wound and skin Plays role in ulcer, wound and skin

burnburnCauses regeneration of tissuesCauses regeneration of tissuesGranulation of tissue formation (8 Granulation of tissue formation (8

days)days)

Antimicrobial activityAntimicrobial activity Purified tannin from SBT having play Purified tannin from SBT having play

roleroleHaving broad spectrum activityHaving broad spectrum activity

Page 19: INTRODUCTION

Cytoproctective & Anti-oxidant Cytoproctective & Anti-oxidant activityactivity

CEH having capacity of anti-oxidantCEH having capacity of anti-oxidant

Increases elimination of free radicalIncreases elimination of free radical

Decreases glutathione peroxidase and Decreases glutathione peroxidase and glutathione levelglutathione level

Decreases cytotoxicity and apoptosisDecreases cytotoxicity and apoptosis

Restore the phagocytic activityRestore the phagocytic activity

Page 20: INTRODUCTION

Role in age related memory Role in age related memory disorderdisorder

Prevent neurological, endocrine & Prevent neurological, endocrine & metabolic effectsmetabolic effects

Alter the level of aminesAlter the level of amines

Prevent Ach level lossPrevent Ach level loss

Page 21: INTRODUCTION

Nerophysiological adaptationNerophysiological adaptation (Cold (Cold stress)stress)

Prevent cardiovascular response to cold stressPrevent cardiovascular response to cold stress

Reduces epinephrine and norepinephrine levelReduces epinephrine and norepinephrine level

Reduces plasma cortisol levelReduces plasma cortisol level

Page 22: INTRODUCTION

Cardiovascular diseasesCardiovascular diseases

Omega-3 fatty acid decreases riskOmega-3 fatty acid decreases risk

Decreases total and LDL cholesterol, Decreases total and LDL cholesterol, triglyceroides & lipoproteinstriglyceroides & lipoproteins

Alter the platelet aggregation factorAlter the platelet aggregation factor

Strengthen the myocardial contractionStrengthen the myocardial contraction

Page 23: INTRODUCTION

Immune mechanismImmune mechanism

Prevent membrane phosphorylatioPrevent membrane phosphorylatio Prod. of Eicosanoids & cytokines Prod. of Eicosanoids & cytokines

Increases serum lysosomes & Alexin levelIncreases serum lysosomes & Alexin level

Increases natural killer cell levelIncreases natural killer cell level

Enhances T-lymphocyte proliferation & IL-Enhances T-lymphocyte proliferation & IL-2 secretion2 secretion

Page 24: INTRODUCTION

Anti-inflammatory activityAnti-inflammatory activity

Carotene, Vit. E & PUFA play roleCarotene, Vit. E & PUFA play role

Counter checks senilism by controlling Counter checks senilism by controlling proteometabolism and metabolism of proteometabolism and metabolism of nucleic acidnucleic acid

Prevent damage due to radiationPrevent damage due to radiation

Facilitate the exudation & hematopedesisFacilitate the exudation & hematopedesis

Enhances cellular infiltration & Enhances cellular infiltration & metabolismmetabolism

Page 25: INTRODUCTION

Anti-tumorigenesisAnti-tumorigenesis

Direct act through general immunityDirect act through general immunity

Inhibits the growth of gastric carcinoma Inhibits the growth of gastric carcinoma & lymphatic leukemia& lymphatic leukemia

Blocks the synthesis of N-nitrosomolaneBlocks the synthesis of N-nitrosomolane

Increases superoxide dismutase activityIncreases superoxide dismutase activity

Page 26: INTRODUCTION

Other activitiesOther activities

Protects from pain in stomach, liver, Protects from pain in stomach, liver, chest & lumbar regionchest & lumbar region

Prevents hepatic damage - CCl4, alcohol Prevents hepatic damage - CCl4, alcohol & paracetamol& paracetamol

Used in gynecological ailmentsUsed in gynecological ailments

Used for treatment of cough & cleaning Used for treatment of cough & cleaning lunglung

Used as cosmeticUsed as cosmetic

Page 27: INTRODUCTION

ToxicityToxicity

Acute & chronic toxicityAcute & chronic toxicity

Toxic dose: Toxic dose: Oil: 20-30 % in diet Oil: 20-30 % in diet

Effects- other than vegetative & CNSEffects- other than vegetative & CNS

Fruit: 40 % in dietFruit: 40 % in diet Increases bilirubin Increases bilirubin Decreases TLCDecreases TLC

Fruits: 100 % feedingFruits: 100 % feedingFatal to all animals Fatal to all animals

Page 28: INTRODUCTION

Store-house of many bioactive substancesStore-house of many bioactive substances

Possesses diverse pharmacological Possesses diverse pharmacological activitiesactivities

Useful for prevention of diseasesUseful for prevention of diseases

Has great nutritional valueHas great nutritional value

As a alternative remedy for treatment of As a alternative remedy for treatment of diseasesdiseases

Page 29: INTRODUCTION

THANKS


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