Internship Report on Remington Pharamacuetical Ltd

1

Remington Pharmaceutical Industry

Origins and Evolution of Pharmaceutical Industry

The modern pharmaceutical industry is a highly competitive non-assembled1 global

industry. Its origins can be traced back to the nascent chemical industry of the late

nineteenth century in the Upper Rhine Valley near Basel, Switzerland when

dyestuffs were found to have antiseptic properties. A host of modern pharmaceutical

companies all started out as Rhine-based family dyestuff and chemical companies

e.g. Hoffman-La Roche, Sandoz, Ciba-Geigy (the product of a merger between Ciba

and Geiger), and Novartis2 etc. Most are still going strong today.

Over time many of these chemical companies moved into the production of

pharmaceuticals and other synthetic chemicals and they gradually evolved into

global players. The introduction and success of penicillin in the early forties and the

relative success of other innovative drugs, institutionalized research and

development (R&D) efforts in the industry 4. The industry expanded rapidly in the

sixties, benefiting from new discoveries and a lax regulatory environment. During

this period healthcare spending boomed as global economies prospered.

The industry witnessed major developments in the seventies with the introduction of

tighter regulatory controls, especially with the introduction of regulations governing

the manufacture of ‘generics’5. The new regulations revoked permanent patents and

established fixed periods on patent protection for branded products, a result of which

the market for ‘branded generics’6 emerged.

2

Brief Introduction

For over 100 years, Remington has been the definitive textbook and reference on the

science and practice of pharmacy. This Twenty-First Edition keeps pace with recent

changes in the pharmacy curriculum and professional pharmacy practice.

More than 95 new contributors and 5 new section editors provide fresh perspectives

on the field. New chapters include pharmacogenomics, application of ethical

principles to practice dilemmas, technology and automation, professional

communication, medication errors, re-engineering pharmacy practice, management

of special risk medicines, specialization in pharmacy practice, disease state

management, emergency patient care, and wound care.

Purchasers of this textbook are entitled to a new, fully indexed Bonus CD-ROM,

affording instant access to the full content of Remington in a convenient and

portable format.

A must-have resource for all in the pharmaceutical industry!

With over two decades of serving your healthcare needs and a vision to enhance the

quality of life, Remington Pharmaceuticals is committed to providing you with best

healthcare solutions. We develop and manufacture pharmaceutical medicines

through our dedicated R&D team and state-of-the-art manufacturing facilities to

ensure not only a healthier today but also, a healthier tomorrow!

Keeping in mind the need for provision of better healthcare services, Remington

aims at providing high-class medicines with greater access for the benefit of

everyone. The company dedicatedly works towards improving the quality of human

life through continuous innovation and hard-work to bring forth a stream of

medicinal products that contribute to the betterment of the society. Remington offers

a broad portfolio of medicines seeking to give maximum benefit to patients.

3

Among the medical professionals and other stakeholders, Remington is best known

for its dedicated people, passion for innovation through research and development

and quality healthcare solutions. Determined to always go beyond its reputation, the

recent development of its new state-of-the-art manufacturing facility is a testimony

of our continuous efforts to bring Remington to the global fore.

Company Information

With over two decades of serving your healthcare needs and a vision to enhance the

quality of life, Remington Pharmaceuticals is committed to providing you with best

healthcare solutions. We develop and manufacture pharmaceutical medicines

through our dedicated R&D team and state-of-the-art manufacturing facilities to

ensure not only a healthier today but also, a healthier tomorrow!

Keeping in mind the need for provision of better healthcare services, Remington

aims at providing high-class medicines with greater access for the benefit of

everyone. The company dedicatedly works towards improving the quality of human

life through continuous innovation and hard-work to bring forth a stream of

medicinal products that contribute to the betterment of the society. Remington offers

a broad portfolio of medicines seeking to give maximum benefit to patients.

Among the medical professionals and other stakeholders, Remington is best known

for its dedicated people, passion for innovation through research and development

and quality healthcare solutions. Determined to always go beyond its reputation, the

recent development of its new state-of-the-art manufacturing facility is a testimony

of our continuous efforts to bring Remington to the global fore.

With a diligent team and a cGMP compliant, 150,000 sq. ft. manufacturing facility

equipped with latest technology, Remington is devoted on ensuring that it delivers

and fulfils its commitments to the fullest. Strictly adhering to international

4

maintenance and monitoring standards and stringent quality control checks, the

company has established an edge over its competitors enabling it to become the

industry benchmark. According to the IMS, Switzerland (Q1, 2008), Remington is

ranked among the top 30 companies from 681 pharmaceutical companies in Pakistan

in terms of unit-wise sales.

Here at Remington, we uphold strong moral values and instill them in our team. We

inculcate an environment that is based on ethical workings and integrity. The

company has also been working towards providing healthcare services to those who

are impoverished and in places where they are non-existent. We believe in giving

back to the society and for that purpose, the company helped establish Pakistan’s

first private pharmaceutical college and has also been funding a number of NGOs

and other non-profit organization such as Red Cross and Ameer Begum Welfare

Trust (ABWT).

In a world that is rapidly growing, Remington’s dynamic thinking and forward-

looking attitude has made it more adaptable to the changing needs of people. The

company envisions growth and partnerships that stretch across the globe. An

infrastructure of global standards, a concatenate R&D team, technological

advancements, long-lasting customer relationships and a mindset geared towards

growth are the key ingredients that are bound to make the company a success in the

future as well.

Company Values

• Creativity leads to innovation which lays the foundation for success.

• Innovative and updated technology to produce the best quality products.

• Utmost care for employees, customers and the society we live in.

• Respect the employees and their contributions at workplace.

5

• Committed to the highest standards of ethics and integrity.

• Teamwork is the lifeblood of the organization.

• Trust in the relationships with clients.

Message from the C.E.O

I would like to thank everyone who has been directly or indirectly involved in

supporting our efforts to make Remington’s name synonymous to trust and quality.

It is with the untiring efforts of our Research & Development, Production, Quality

Assurance, Material Management, Engineering, Sales & Marketing, Regulatory

Affairs, Human Resource and Corporate Finance teams, that we have achieved

many valuable milestones in the short history of the Company.

Not only Remington, but the whole Pharmaceutical industry in Pakistan is at the

crossroads to be counted or to be neglected in the global arena. At Remington we

have committed all our energies towards making ourselves a recognized leader in

the global pharmaceutical industry by providing quality medicines at an affordable

price.

The new millennium represents the promise of a better future and the reality of rapid

and unpredictable change. To excel, those who will manage, must combine logic

with intuition and solid academic training with bold vision.

Dr. Khokhar is one of the leading figures in the pharmaceutical sector of the

country. He has represented the industry on various national and international

forums. He has been elected Chairman of Pakistan Pharmaceutical Manufacturer's

Association (PPMA) twice and has been the President of Pakistan Pharmacist

Association (PPA), Punjab. He represented PPMA on the Registration and Licensing

Boards, Ministry of Health - Pakistan.

6

He has been a member of various national policy making bodies, including the

Committee for Monitoring Drugs Sector (CMDS), the Board of Governors of

Pakistan Medical Research Council (PMRC), the Central Pharmacy Council, the

Governing Council of Pakistan Council of Scientific and Industrial Research

(PCSIR). He has also been a member of the Pakistan Pharmacopoeia Committee, the

National Formulary Committee, the Good Manufacturing Practice Award

Committee and the Private Sector Advisory Council - constituted by the Prime

Minister of Pakistan. On behalf of the Government of Pakistan and the Company,

Dr. Khokhar has attended numerous conferences in North America, Europe and

Asia.

Over his illustrious career, Dr. Khokhar has also contributed significantly in the

education sector of Pakistan. He has been on the Board of Studies and the Board of

Faculty of Pharmacy at the University of Punjab. He was nominated a member of

the Study Group on Pharmacy Education, by the Higher Education Commission

(HEC), Pakistan. He was also instrumental in helping start the first ever private

sector pharmacy institution in Pakistan.

Dr. Khokhar's contributions are not only limited to the corporate and the education

sectors, but also stretch to the field of sports. He is the Life President of Pakistan

Gymnastic Federation (PGF) and has always strived to raise the profile of the sport

in Pakistan. He has also participated in the activities of the Pakistan Olympic

Association, the body which represents Pakistan on the International Olympic

Association.

Along with his accomplishments in the corporate sector, Dr. Khokhar is recognized

as one of the most eminent pharmacists in Pakistan. After completing his B.

Pharmacy from the University of Punjab, he completed his MPhil in Pharmacy from

the University of Wales. He pursued his doctorate at King's College London, where

7

he joined the Research Group of Professor Arnold H. Beckett - an eminent scientist

of world repute. His outstanding contributions during and after his Ph.D. were

greatly appreciated by his co-researchers, he also authored several research papers in

international journals.

Vision and Mission

Remington Pharmaceuticals was established with a vision to enhance the quality of

health care services in Pakistan. Today, we have not only become the benchmark in

producing superior quality medicines while adhering to the international standards,

but we have also contributed significantly in upgrading the healthcare services in

many parts of rural and urban Pakistan.

Ophthalmology is an expertise area that Remington pharmaceutical now

successfully dominates. Our product brand portfolio covers a wide range of

therapeutic areas, the major ones being Ophthalmic medicines, Anti-infective,

Dermatology and Anti? Ulcerant products

According to the data released by IMS (Switzerland) for the first quarter of 2005,

Remington Pharmaceuticals is ranked 17th (Unit wise) among the 596

pharmaceutical companies in Pakistan.

Credit to Success

We conduct ourselves with the utmost Integrity in all our dealings

Good is the enemy of Great. We must strive for Excellence

Innovative thinking leads to out-of-the-box solutions. Always add value!

Perseverance should be a habit. Never ever give up!

People are our guiding beacon. Promptly deliver to their needs

8

Trust Regmination

We strive for excellence in every mile we run. Nothing takes our attention more than

delivering quality products to doctors, pharmacists and patients. That is why today,

Remington is taking care of millions of people trusting our medicines for their

wellbeing.

Our manufacturing facilities are designed to ensure our commitment to quality at

every step of the production process. Computerized building management systems

provide required environment round the clock and, in addition to that, extensive

equipment automation ensuring Quality by Design.

We work hard as a team so that you can be rest assured of getting the highest quality

medicine from Remington.

Structu ral Industry Analysis (Porter’s Five Forces)

This section provides a summary positional analysis of the pharmaceutical industry

using Porter’s Five Forces model (see diagram below)

9

• Barrier to entry: High (Pharmaceuticals). Cost of R&D and patent limitations

• Industry Competition: High. Advantages gained by first mover advantage

(patents)

• Suppliers: supplier power is low

• Buyers: buyer power is low

• Substitutes: low (with patents) medium (after patent expiry)

Overall, the pharmaceutical industry shows an upward trend in its core markets. The

industry remains highly valued has a favorable market position with strong financial

make-up and strong earnings growth. Its future potential demand trend is positive

and despite increased competition the industry still shows a continuing upward

growth momentum. Datamonitor’s9 forecast of the leading 16 pharmaceutical

companies for 2001 to 2007 suggests that combined sales will grow at a minimum

rate of 5.2 percent based on the potential of their product pipeline.

Products

Remington manufactures and markets pharmaceutical drugs. A manufacturing

facility equipped with state-of-the-art technology and an extremely competent R&D

team ensures that the products provided by the company meet international

standards and are of the highest quality. The company’s product base covers a wide

range of therapeutic areas. We make sure that our medicinal products exactly fulfill

the requirements of both physicians and patients. Through continuous innovation,

we aim to keep broadening our product mix to serve an increasingly large number of

therapeutic areas. We focus on upholding and furthering our brand name and in

becoming a market-wide leader in the pharmaceutical industry.

10

Products for International Market

Remington manufactures and markets pharmaceutical drugs. A manufacturing

facility equipped with state-of-the-art technology and an extremely competent R&D

team ensures that the products provided by the company meet international

standards and are of the highest quality. The company’s product base covers a wide

range of therapeutic areas. We make sure that our medicinal products exactly fulfill

the requirements of both physicians and patients. Through continuous innovation,

we aim to keep broadening our product mix to serve an increasingly large number of

therapeutic areas. We focus on upholding and furthering our brand name and in

becoming a market-wide leader in the pharmaceutical industry.

ANTHELMINITIC

GENERIC NAME BRAND NAME PRODUCT TYPEPACK

SIZEPACK TYPE

Piperazine REMIPAR

ELIXIR

Syrup 30ml Glass Bottle

ANTI-ANAEMIC

GENERIC NAMEBRAND

NAME

PRODUCT

TYPE

PACK

SIZE

PACK

TYPE

Iron (III) Hydroxide

Polymaltose Complex

FEMTOL Syrup 60ml Glass

Bottle

11

Iron (III) Hydroxide Polymaltose

Complex

FEMTOL Tablets 10’s Blister

Iron (III) Hydroxide Polymaltose

Complex

FEMTOL-F Tablets 10’s Blister

ANTI-ASTHMATIC

GENERIC NAME BRAND NAMEPRODUCT

TYPE

PACK

SIZE

PACK

TYPE

Ketotifen ASFEN Syrup 60ml Glass

Bottle

Ketotifen ASFEN Tablets 30’s Blister

Montelukast REMIKAIR 4mg Sachet 28’s Aluminiu

m

Montelukast REMIKAIR 4mg /

5mg / 10mg

Tablets 14’s Blister

ANTI-BACTERIAL QUINOLONE


TYPE

PACK

SIZE

PACK

TYPE

Ciprofloxacin ROCIP 250mg /

500mg


Levofloxacin KOBEXIN 250mg /

500mg


Moxifloxacin OCUMOX Tablets 5’s Blister

Norfloxacin BACTINOR Tablets 14’s Blister

12

Ofloxacin CIOF Tablets 10’s Blister

Sparfloxacin Q-LOX 100mg /

200mg


ANTI-BIOTIC / ANTI-INFECTIVE


TYPE

PACK

SIZE

PACK

TYPE

Amoxycillin WISEP Drops 10ml Glass

Bottle

Amoxycillin WISEP Suspension 60ml Glass

Bottle

Amoxycillin WISEP Tablets 100’s Blister

Amoxycillin WISEP-1000 Tablets 10’s Blister

Amoxycillin WISEP-DS Suspension 60ml Glass

Bottle

Amoxycillin WISEP-DS Tablets 20’s Blister

Amoxicillin-Clavulanic

Acid

MAGNICILLIN Tablets 6’s Blister

Amoxicillin-Clavulanic

Acid

MAGNICILLIN Suspension 60ml Glass

Bottle

Amoxycillin-

Flucloxacillin

FLOMOXIN Capsules 20’s Plastic

Bottle

Amoxycillin- FLOMOXIN Suspension 45ml Glass

13

Flucloxacillin Bottle

Azithromycin MACRO-AZ Capsules 10’s Plastic

Bottle

Azithromycin MACRO-AZ Suspension 15ml Glass

Bottle

Cefadroxil DROXIL Capsules 12’s Plastic

Bottle

Cefadroxil DROXIL Suspension 60ml Glass

Bottle

Cefadroxil DROXIL-1000 Tablets 10’s Blister

Cefadroxil DROXIL-DS Suspension 60ml Glass

Bottle

Cefixime ZYLOFIXIM Capsules 5’s Plastic

Bottle

Cefixime ZYLOFIXIM Suspension 30ml Glass

Bottle

Cefixime ZYLOFIXIM-DS Suspension 30ml Glass

Bottle

Cephradine ZEFLIN Capsules 12’s Plastic

Bottle

Cephradine ZEFLIN Suspension 60ml Glass

Bottle

Cephradine ZEFLIN-DS Capsules 12’s Plastic

14

Bottle

Cephradine ZEFLIN-DS Suspension 60ml Glass

Bottle

Doxycycline Hyclate VOXIN Tablets 20’s Blister

Fosfomycin MIFOS Capsules 10’s Blister

Fosfomycin MIFOS Suspension 60ml Blister

ANTI-CONVULSANT


TYPE

PACK

SIZE

PACK

TYPE

Gabapentine NEUROGAB 200mg /

400mg / 600mg


ANTI-DIABETIC


TYPE

PACK

SIZE

PACK

TYPE

Glimepiride DIARID 1mg / 2mg /3mg /

4mg


Glimepiride-Metformin DIARID-M 1mg-500mg Tablets 30’s Blister

Pioglitazone XOGLIT 15mg / 30mg /

45mg


Pioglitazone-Metformin XOGLIT-M 15mg-500mg Tablets 28’s Blister

Pioglitazone-Metformin XOGLIT-M 15mg-850mg Tablets 14’s Blister

ANTI-EMETIC

15


TYPE

PACK

SIZE

PACK

TYPE

Domperidone KOMETIC Suspension 120ml Glass Bottle

Domperidone KOMETIC Tablets 50’s Blister

ANTI-HISTAMINE


TYPE

PACK

SIZE

PACK

TYPE

Cetrizine ZINOLUR Tablets 10’s Blister

Loratidine TILORA Syrup 60ml Glass Bottle

Loratidine TILORA Tablets 10’s Blister

ANTI-OBESITY


TYPE

PACK

SIZE

PACK

TYPE

Sibutramine LOWBEST 10mg /

15mg

Capsules 14’s Blister

ANTI-PEPTIC ULCERANT


TYPE

PACK

SIZE

PACK

TYPE

Cimetidine SEMAG Tablets 10’s Blister

Famotidine TINOPEP 20mg Tablets 20’s Blister

Famotidine TINOPEP 40mg Tablets 10’s Blister

Omeprazole INGIS Capsules 14’s Plastic

16

Bottle

Pantoprazole PANTO Tablets 14’s Blister

Ranitidine RANIFUR Tablets 10’s Blister

Ranitidine RANIFUR-DS Tablets 10’s Blister

Lansoprazole ZOXILAN Capsules 14’s Plastic

Bottle

ANTI-RHEUMATIC


TYPE

PACK

SIZE

PACK

TYPE

Diclofenac Potassium FLAMY 50mg Tablets 20’s Blister

Diclofenac Potassium FLAMY 100mg Tablets 10’s Blister

Diclofenac Sodium KONAC Tablets 20’s Blister

Flurbiprofen FLURIBEC Tablets 30’s Blister

Leflunomide RHEUMID 10mg /

20mg


Meloxicam MELOX 7.5mg / 15mg Tablets 10’s Blister

Piroxicam KEMROX 10mg / 20mg Capsules 1’s Blister

ANTI-VIRAL


TYPE

PACK

SIZE

PACK

TYPE

Ribavrin VIROFF 100mg / 200mg / Capsules 10’s Blister

17

400mg

Ribavrin VIROFF 600mg Tablets 10’s Blister

Ribavrin VIROFF 50mg / 100mg Syrup 60ml Glass

Bottle

CARDIOVASCULAR


TYPE

PACK

SIZE

Simvastatin-Ezetimibe TIMVAST PLUS 10mg-10mg /

20mg-10mg

Tablets 7’s

Simvastatin-Ezetimibe TIMVAST PLUS 40mg-10mg Tablets 10’s

Rosuvastatin ROSULIP 5mg / 10mg / 20mg Tablets 10’s

Candesartan KANPRESS 8mg Tablets 14’s

Candesartan KANPRESS 16mg Tablets 28’s

Candesartan-

Hydrochlorothiazide

KANPRESS PLUS Tablets 28’s

Clopidogrel-Aspirin CEGREL-A 75mg-75mg / 75mg-

150mg

Tablets 10’s

Lisinopril-

Hydrochlorothiazide

ZIDOPRIL Tablets 28’s

Ramipril RAPRIL 1.25mg / 2.5mg / 5mg /

10mg

Tablets 28’s

Amlodipine-Atorvastatin MYODIP 5mg-10mg / 5mg-Tablets 7’s

18

20mg

Amlodipine-Atorvastatin MYODIP 10mg-10mg Tablets 10’s

Valsartan VALZAR 80mg / 160mg Tablets 14’s

Valsartan-

Hydrochlorothiazide

VALZAR PLUS 80mg-12.5mg Tablets 28’s

Valsartan-

Hydrochlorothiazide

VALZAR PLUS 160mg-25mg Tablets 14’s

COUGH & COLD PREPARATIONS


TYPE

PACK

SIZE

PACK

TYPE

Ammonium Chloride REMISOLE

EXPECTORANT

Syrup 60ml /

120ml

Glass

Bottle

DERMATOLOGY


TYPEPACK SIZE PACK TYPE

Benzyl Banzoate S.P. LOTION Lotion 60ml /

120ml

Glass Bottle

Flucinolone Acetonide CINOL Cream 15gm Aluminium

Tube

Flucinolone Acetonide CINOL Ointment 15gm Aluminium

Tube

19

Flucinolone Acetonide-

Neomycin

CINOL-N Cream 15gm Aluminium

Tube

Flucinolone Acetonide-

Neomycin

CINOL-N Ointment 15gm Aluminium

Tube

Miconazole Nitrate MONITIN Cream 30gm Aluminium

Tube

Miconazole Nitrate GYNO MONITIN Cream 20gm Aluminium

Tube

Miconazole Nitrate-

Diflucortolone

MONICORT Cream 10gm Aluminium

Tube

Polymyxin B. Sulfate-Zinc

Bacitracin

ZYLOSPORE Ointment 10gm/20gm Aluminium

Tube

Salicylic Acid-Sulphur SEPRODERM Ointment 20gm Glass Bottle

EAR, NOSE & THROAT


TYPE

PACK

SIZE

Betamethasone BETADROP Ear Drops 7.5ml

Betamethasone-Neomycin BETADROP-N Ear Drops 7.5ml

Chloramphenicol REMICOL Ear Drops 10ml

Ciprofloxacin-Lignocaine LIGNOCIP Ear Drops 5ml

20

Ciprofloxacin OTOCIP Ear Drops 5ml

Dexamethasone-Ciprofloxacin DEXCIP Ear

Suspension

5ml

Fluticasone Propionate FLUTEX Nasal Spray 15ml

Gentamicin OPTAGEN Ear Drops 7.5ml

Gentamicin-Hydrocotisone OPTAGEN-HC Ear Drops 5ml

Levofloxacin-

Dexamethasone

LEFODEX Ear

Suspension

5ml

Ofloxacin 0.3% KUNOXY Ear Drops 5ml

Ofloxacin 0.6% KUNOXY Plus Ear Drops 5ml

Polymyxin-Neomycin-

Hydrocortisone Acetate

POLYSPORE-HC Ear

Suspension

5ml

Polymyxin B-Lignocaine OTOCAINE Ear Drops 5ml

Sodium Cromoglycate NOSOCROM Nasal Spray 15ml

21

Sodium Cromoglycate-

Xylometazoline

NOSOCROM -X Nasal Spray 13ml

Tobramycin TOBEC Ear Drops 5ml

Tobramycin-Dexamethasone TOBEC-D Ear Drops 5ml

Triamcinolone Acetonide NOSOLONE-AQ Nasal Spray 15ml

EYE DROPS


TYPE

PACK

SIZE

Atropine Sulphate OPTA ATROPINE Solution 10ml

Betamethasone BETADROP Solution 7.5ml

Betamethasone-Neomycin BETADROP-N Solution 7.5ml

Chloramphenicol OPTACHLOR Solution 10ml

Chloramphenicol-Dexamethasone METHACHLOR Solution 5ml

Ciprofloxacin ROCIP Solution 5ml

22

Dexamethasone OPTADEX Solution 5ml

Dexamethasone-Neomycin OPTADEX-N Solution 5ml

Dexamethasone-Neomycin-

Polymyxin B.

STERIBIOL Suspension 5ml

Dexamethasone-Sulphacetamide METHASUL Solution 5ml

Dexamethasone-Polymyxin B.-

Neomycin

POLYDEX Solution 5ml

Diclofenac Sodium KONAC Solution 5ml

Flourometholone-

Tetrahydrozoline

FEMICON Suspension 5ml

Gentamicin OPTAGEN Solution 7.5ml

Gentamicin-Hydrocortisone OPTAGEN-HC Solution 5ml

H.P.M.C. HICEL Solution 5ml

Latanoprost PROSTILET Solution 2.5ml

Latanoprost-Timolol PROSTILET-T Solution 2.5ml

23

Moxifloxacin OCUMOX Solution 5ml

Norfloxacin BACTINOR Solution 5ml

Ofloxacin CIOF Solution 5ml

Prednisolone-Neomycin-

Polymyxin B.

BIOPRED Suspension 5ml

Prednisolone Acetate MILDOPRED Suspension 5ml

Prednisolone Acetate FORTIPRED Suspension 5ml

Prednisolone-Chloramphenicol PREDNICOL Suspension 10ml

Prednisolone-Sulphacetamide MYDOSONE Suspension 5ml

Pyrilamine Maleate-

Phenylephrine

DECON-A Solution 15ml

Sodium Cromoglycate HISTALYN Solution 5ml

Sodium Cromoglycate-

Tetrahydrozoline

HISTAZOLIN Solution 15ml

24

Sulphacetamide Sodium OPTACID 10% / 20%

30%

Solution 10ml

Timolol BLOTIM 0.25% / 0.5% Solution 5ml

Tobramycin NEBRA Solution 5ml

Tropicamide MYDROMIDE Solution 5ml

EYE OINTMENT


TYPE

PACK

SIZEPACK TYPE

Acyclovir LOVIR Ointment 4.5gm Aluminium

Tube

Atropine Sulphate MYDRA Ointment 3gm Aluminium

Tube

Betamethasone-Neomycin BETA-N Ointment 3gm Aluminium

Tube

Chloramphenicol OPTACHLOR Ointment 5gm Aluminium

Tube

Chloramphenicol-

Dexamethasone

METHACHLOR Ointment 3gm Aluminium

Tube

Chlorobutanol T-WET Ointment 3.5gm Aluminium

Tube

25

Ciprofloxacin ROCIP Ointment 3.5gm Aluminium

Tube

Dexamethasone-

Sulphacetamide

METHASUL Ointment 3.5gm Aluminium

Tube

Neomycin - Polymyxin B.

-Dexamethasone

STERIBIOL Ointment 3.5gm Aluminium

Tube

Oxytetracycline-

Polymyxin B.

XINOXY Ointment 3gm Aluminium

Tube

Polymyxin-Neomycin-

Zinc Bacitracin

TRIMIN Ointment 5gm Aluminium

Tube

Polymyxin B.-

Zinc Bacitracin

ZYLOSPORE Ointment 4gm Aluminium

Tube

Polymyxin B.-

Zinc Bacitracin -

Neomycin -

Hydrocortisone

POLYSPORE-HC Ointment 3gm Aluminium

Tube

Prednisolone-Neomycin-

Polymyxin B

BIOPRED Ointment 3.5gm Aluminium

Tube

Prednisolone-

Sulphacetamide

MYDOSONE Ointment 3.5gm Aluminium

Tube

Tobramycin NEBRA Ointment 5gm Aluminium

Tube

GASTROPROKINETICS

GENERIC NAME BRAND NAME PRODUCT PACK PACK

26

TYPE SIZE TYPE

Itopride TOPRID Tablets 10’s Blister

MUSCLE RELAXANT


TYPE

PACK

SIZE

PACK

TYPE

Orphenadrine

Citrate-Paracetamol

FLEXODIN Tablets 100’s Blister

NON NARCOTIC ANALGESIC


TYPE

PACK

SIZE

PACK

TYPE

Mefenamic Acid FEBRIN Tablets 100’s Blister

Mefenamic Acid FEBRIN-DS Tablets 100’s Blister

VITAMINS


TYPE

PACK

SIZE

PACK

TYPE

Alfacalcidol DOLBON 0.25mcg / 0.5mcg /

1mcg

Tablets 10’s Tablet

Thiamine-Riboflavine-

Pyridoxine-Nicotinamide

PLEXOVIT Syrup 60ml /

120ml

Glass

Bottle

B-Compound

Lysine Syrup

PLEXOVIT-L Syrup 60ml /

120ml

Glass

Bottle

Antioxidant Vitamins

(Beta Carotene, C, E),

VISAVIT Tablets 30’s Plastic

27

Mineral (Zn, Cu, Se),

Folic Acid and

Vitamin D

Bottle

Antioxidant Vitamins

(Beta Carotene, C, E),

Mineral (Zn, Cu, Se),

Folic Acid and

Vitamin D

VISAVIT PLUS Tablets 30’s Plastic

Bottle

Multi Vitamin VITONE Syrup 60ml /

120ml

Glass

Bottle

Multi Vitamin VITONE FORTE Syrup 120ml Glass

Bottle

Multi Vitamin VITONE FORTE Tablets 20’s Plastic

Bottle

International Business

Licensing & Alliances Various Coutries

We at Remington Pharmaceuticals understand the need for collaborative

development and marketing of drugs to achieve higher growth levels. Be that

through in-licensing or co-marketing, we seek to enhance our presence both

regionally and globally by partnering in areas where we can leverage on our

complementary expertise and exploit synergies.

Remington Pharmaceuticals is one of the leading pharmaceutical companies in

Pakistan and with the commencement of a cGMP compliant, 150,000 sq. ft., multi-

drug manufacturing facility we are augmenting our presence in the Asian, Middle

28

Eastern and African markets. Built on strong foundations of commitment to

excellence, today, Remington’s strong brand has become synonymous to highest

standards.

Our key strength areas include:

Our team’s in-depth know-how and expertise right from rapid drug

registrations to generating substantial sales in short spans of time.

Our proven business model and strategic understanding of the markets assist

our partners gain forceful market entry across the region.

Our successful track record of carrying out R&D, manufacturing quality drugs

and the marketing skills of our team puts us in a strong position to

successfully execute launches in multiple therapeutic areas.

Our close working relationship with regulatory authorities, medical

professionals and other related associations & societies allows us to introduce

our partner products on a fast track.

Manufacturing Process

Recognition and Appreciation

Our manufacturing facility boasts enhanced production capacities for Eye and Ear

Drops, Ointments, Liquid (Oral) Medicines, Coated and Uncoated Tablets, Capsules

and External Preparations for various therapeutic categories.

The manufacturing facility is equipped with the latest technology including

automated and dedicated process control systems, computerized HVAC/dust control

mechanism, computerized Building Management System (BMS) and, process–water

and waste–water management systems providing with a ready compliance to cGMP,

ISO 9001:2000(E) and ISO 14001. Delegates from Europe and the US have visited

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and admired the quality standards maintained at Remington’s production facilities.

This has led us to formalize transnational relationships and enhance our strategic

partnerships.

Contract Manufacturing

Remington’s dedicated and competent R&D team, a state-of-the-art manufacturing

plant that meets the highest international standards coupled with the company’s vast

experience and expertise in Pharmaceutical Manufacturing and its strong ethical

values ensuring protection of intellectual property rights enable it to provide with a

complete outsourcing solution.

Using cGMP compliant and regulatory authorities’ approved manufacturing

processes, our production facility boasts enhanced production capacities for Eye and

Ear Drops, Ointments, Liquid (Oral) Medicines, Coated and Uncoated Tablets,

Capsules and External Preparations for various therapeutic categories.

At Remington, an ISO 9001:2000(E) certified company, a planned and systematic

pattern of all means and actions is designed to ensure that its products meet the

established standard specifications, legal requirements and the organization’s quality

objectives.

Contract manufacturing carries significant advantages some of which include:

Low Upfront Cost due to minimal capital requirement and a legal and tax presence not

being necessary

Flexibility through being able to ramp up production volumes rapidly

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Fast-track Processing as a consequence of short lead-team for final production

Access to External Expertise

Greater Adaptability to the ever changing demands of the market allowing for greater

revenue growth

The company provides tailored services to meet the clients’ needs by making

available the requested information including the following reports:

Inventory levels & movements

Batch monitoring & reports

Quality assurance reports

We strive to create a win-win situation by providing cost-effective and profitable

solutions for our partners.

Production Capacity

The annual production capacity of each section running on two 8 hour shifts, which

can be extended up to three shifts daily, is as follows:

Capsules 30 million capsules

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Dry Syrups 12 million bottles

Ear Drops 12 million bottles

Eye Drops 60 million bottles

Eye Ointments 12 million tubes

Lotions 14 million bottles

Skin Ointments 12 million jars & tubes

Syrups 60 million bottles

Tablets 800 million tablets

Quality by Design

The manufacturing team is committed to produce highest quality products which can

meet the needs of both doctors and patients. The team strives to manufacture

products that are cost-effective through best utilization of their resources, reduced

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down-time and by extensively applying planned-preventive maintenance program

with coordination of a highly skilled engineering team.

Our production facilities meet the regulatory requirements of cGMP and regulatory

authorities. All the manufacturing activities are performed according to the approved

procedures as required by cGMP and ISO 9001:2000(E) quality management

system.

In addition to quality assurance department's procedures at every stage of

production, in-process checks are also imposed, the results of which are

continuously monitored and recorded. Materials are procured from approved

suppliers through documented procedures, are quarantined until tested and released

for use by the manufacturing department. These materials are dispensed under

strictly controlled conditions supervised by our Quality Assurance team.

QUALITY ASSURANCE

At Remington the core quality management groups cut across all functional

departments to coordinate and monitor the implementation of the quality policy and

quality management system. The quality assurance team effectively focuses on each

step starting from the raw material souring to packing and storing of the finished

products.

Internal Quality Assurance

External Quality Assurance

Effectiveness and Suitability of Quality System

Being an ISO 9001:2000(E) certified company, we have extended our efforts to the

Total Quality Management Program for the benefit of the organization itself, its

members and of the society as a whole.

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To run the quality system effectively and produce highest standard products, all the

required human, material, technical and financial resources are periodically and

thoroughly reviewed. The prime objective is the effective management of our

operations and substantiation of activities within the organization. These resources

include but are not limited to:

Human Resource Skills

Design and Development Equipment

Inspection, Testing and Examination Equipment

Instrumentation and Computer Software

Here at Remington, a planned and systematic pattern of all means and actions is

designed to ensure that our products meet the established standard specifications,

legal requirements and the organization’s quality objectives.

Collaboration Opportunities

Partnering with European / US Companies

For global and specialist pharmaceutical companies looking to enter the Asian,

Middle Eastern and African markets, Remington offers its unique platform to

partner in these regions.

With a vast knowledge of the region, Remington can streamline the difficulties

faced when launching a product in the aforementioned regions. Our team is well

versed in dealing with geographic areas where lack of information on market trends,

healthcare policies and reforms, and local doctors & patients are some of the main

challenges. Using our vast experience we successfully tackle these challenges hence

de-risking the market entry of our partners’ products and providing a perfect

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platform to achieve high growth. We have a step-by-step market entry process that

involves initiating the process by carrying out comprehensive top-down market

analysis followed by formulating optimal strategies for entering a given market.

We appreciate that each partner is unique in its culture and business model; hence

we strive to provide customised solutions to contribute to our business partners'

success. To share the market entry risks, we also co-invest with our partners.

In summary, we are interested in sales and marketing partnerships and are keen to

explore licensing opportunities to create regional successes. We are not limited by

speciality areas and evaluate diverse opportunities to add to our portfolio of products

to expand our therapeutic and geographic coverage. Licensing innovative and ‘first

time’ products in the region across multiple therapeutic classes is of particular

interest to us.

We deal with our partners with highest level of integrity and strive to build long-

lasting, mutually beneficial relationships that add value for us and for our partners.

Research and Development

Remington Pharmaceuticals has developed one of the most progressed and sensitive

R&D facility in the country. The core strength of our team is our foresightedness

that enables us to come up with the desired product at the apposite time. The in-

depth knowledge of the industry, science and the technology help us develop new

and effective products for the most pernicious diseases.

We have on our R&D team scientists with vast knowledgebase. To keep up with the

pace of today’s fast growing pharmaceutical industry, the R&D team regularly

participates in technical programs and seminars so that they are better able to tackle

new challenges and help develop better products. To facilitate the R&D team,

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Remington’s laboratory is designed and equipped to meet international standards.

The R&D team is working on developing multi-therapeutic products pipeline.

At Remington Pharmaceutical we are committed to thrive and bring forth new

products which will help us in serving the humanity in a more effective way. With a

dedicated R&D team and facilities of international standards, we believe that

together we will be able to meet the challenges and continue our drive towards

progress.

COMPANY’S MARKETING & DISTRIBUTION

Laborate follows push strategy with robust distribution system as follows:

The sale generated by company to distributor is termed as Primary sales. Laborate

doesn’t believe in advertisement. It has aggressive and vibrant field force to promote

their products in the market especially to stockiest, retailers as follows:

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Respnesibility

Valuing the community we live in and the environment has always been an integral

part of Remington’s policy. Remington considers itself a part of the community and

has always strived to make a difference for the betterment of the wider populace

through not only providing quality medicines at affordable prices but also, by giving

something back to the community. We have always made sure that our business

operations are carried out in a manner that protection of the environment remains

one of our top most priorities. Remington is moving towards becoming a carbon-

neutral company by offsetting its carbon emissions through the deployment of

renewable energies for power generation.

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Community Support

Remington donates regularly to the NGOs and other foundations to help those who

are in dire need so that they can become responsible citizens and equally contribute

for the advancement of the country. The company continuously supports non-profit/

charitable organizations like Red Cross and ABWT.

The Indian Ocean Tsunami struck in the year 2004 killing millions of people in

areas including India, Sri Lanka, Indonesia and Thailand. Remington stepped up for

the support of all those affected by what was one of the deadliest natural disasters in

history. The company worked with international organizations like the Red Cross to

provide both financial aid and medical provisions to the aforementioned tsunami-

struck areas.

The year 2005, in a time of crisis when the whole country especially the Northern

areas were jolted by strong quakes, being a responsible part of the community,

Remington was among the first few to extend their full financial and emotional

support to the quake-affected people. The company made unrelenting efforts at

making medical provisions available to those affected and helped in the

reconstruction of quake-torn houses.

We believe that education plays a vital role in better equipping the youth to make

positive contributions to the society as a whole and bringing about development.

One of Remington’s keys strengths have been its vast knowledge base and we are

committed on empowering our younger generation with that knowledge and more

and for that purpose, in the 90s the company helped establish Pakistan’s very first

private pharmaceutical college in Lahore. The college aims at providing quality

education and in departing invaluable knowledge to the budding youth of the

country. Our senior management team also regularly gives seminars and conducts

workshops at local public institutions.

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We also promote healthy living and encourage people of all ages to engage in sports.

Recently Remington held a Polo Tournament for this very purpose. Special training

camps were held for younger people so that they make healthy activities a part of

their routines from an early age. The team at Remington also actively participated in

the tournament which served as an effective means for team-building. Remington

has also sponsored a polo team on a number of occasions.

Environment

The world is witnessing increasing globalization with the global markets evolving

continuously. Remington not only strives to adapt itself to the changing needs of the

world but also, in upholding strong values that inculcate in the team an

understanding of the need to protect the environment through clean and efficient

means of manufacturing and production. We believe that through a cleaner

environment we can better ensure a healthier tomorrow.

Analysis of Key Industry Participants and Strategy

This section provides a descriptive overview on the top three pharmaceutical firms

worldwide.

Pfizer\Pharmacia:

After its merger with Warner-Lambert in July 2000, Pfizer became the world’s

largest pharmaceutical company. The strong commercial potential of Pfizer’s

product portfolio and its strong products pipeline, has caused Pfizer to invest heavily

in product support, global sales force expansion and increased R&D spend. In April

2003 the merger of Pfizer Inc. and Pharmacia Corporation was announced. The

estimated $60 billion merger consolidates Pfizer’s position as the world's largest

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pharmaceutical company. The merged entity will control 11% of the global

pharmaceutical market, from 8%, with annual revenue estimated to increase from

$32 billion to $46 billion. The new Pfizer will also control 50% more of the market

than its closest rival, the world's second largest drug company, GlaxoSmithKline10.

The European Commission approved the merger but demanded that the firm divest

pharmaceuticals in nine different areas in response anti-competitive charges.

GlaxoSmithKline:

The December 2000 merger of GlaxoWellcome and SmithKline Beecham created

the GlaxoSmithKline, the world's second largest pharmaceutical company with a

global market share of 7%. GSK has global pharmaceutical sales of over $22bn and

also the largest share in several therapeutic areas, including the vaccine and over-

the-counter products (OTC).

However, GSK is still arguably a more global company (in terms of spread) than

Pfizer, given that GSK generates a far higher proportion of its sales outside the

North American market. GSK is ahead of Pfizer in every other region outside North

America. GSK generated a relatively high $6.0bn, or 26.6% of its sales, in the

European market in the year to September 2002 compared to Pfizer's $3.8bn

(16.9%). The region in which Pfizer's market share is closest to GSK's is Africa,

Asia and Australasia; this is due mainly to GSK’s strong position in the large

Japanese market, which has been targeted by Pfizer for future growth.

Merck & Co:

Merck is the third-largest global pharmaceutical company. Excluding organic

growth, for Merck to rival the top two it will have to acquire at least one of the 15

leading pharmaceutical firms in the world - a smaller acquisition would not gain it

sufficient market share to overtake either Pfizer or GSK. While it has not gone for a

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full-blown merger, Merck, like other drug companies, has increased the number of

collaborations with external and biotech firms. It has so far signed close to 50 deals

with research partners in the past 5 years. Merck has also teamed with Schering-

Plough to develop respiratory drugs. Merck's strategy is to focus on breakthrough

drugs, rather than go the consolidation route or imitate competitors with so-called

"me-too" products. Unfortunately its current product pipeline is rather weak and

Merck may come under increased pressure to merge as a means of gaining market

share and growth. Analysts believe Merck’s ideal merger candidate would be

Johnson & Johnson due to the little overlap with Merck’s pharmaceutical portfolio.

SWOT Analysis and Strategy Review

Since inception in 1849, Pfizer has grown from a small family firm with two

employees into a global enterprise with 95,000 employees on six continents. Pfizer

has increasingly focused its efforts on R&D and this remains its core business

strategy. Pfizer’s strengths lie in its strong pipeline of innovative pharmaceutical

compounds and strong marketing capabilities. Pfizer's performance is characterized

not only by size, but also by growth. In 1999, Pfizer achieved 20% revenue growth.

Pfizer has also set records in each of the past three years to 2003 with the most

successful product launches in pharmaceutical history Lipitor, Viagra and Celebrex.

Pfizer’s strength in R&D, marketing, and sales has made them a partner of choice

for many companies in the pharmaceutical industry and they are involved in a wide

variety of research collaborations and a large number of licensing agreements with

universities, institutes and organizations.

An outline SWOT analysis of the world’s largest pharmaceutical firm follows next.

Strengths

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• R&D innovation with a broad therapeutic coverage

• Marketing strength in major geographical and therapeutic areas

• Existing Patent protection for a number of years on key products

Opportunities

• Decreasing development time through favorable R&D collaborations and

internal efforts

• Emergence of integrated global markets and globalization for new products

• Co-marketing agreements with companies wishing to capitalize on Pfizer's

marketing strengths, providing Pfizer with strong products and therefore

revenue growth

Weaknesses

• Discontinuation of products in the latter stages of development

• Co-marketing agreements can limit Pfizer's global presence

• Increased size and operational complexity makes Pfizer a less agile company

Threats

• Increased competition for core products like Viagra as its high cost

encourages use of cheap alternative treatments

• An increase in the number of safety issues surrounding Viagra

• Competition from products similar to Pfizer's in R&D that reach the market

close to or before Pfizer's products

• The new economic potential of emergent China, India and competition in

diverse regional markets.

Constraints

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1. Found a little bit difficulty initially in meeting with the company guide to get

the assignments due to his busy schedule.

2. Company didn’t want to involve trainees in their business directly.

3. Most of the chemist doesn’t provide their Sales information easily.

Strategy adopted :

1. Strictly follow work-timings from 9:00 a. m to 6:00 p.m.

2. Zeal to learn from existing employees.

3. Passion & Dedication towards work to prove myself.

4. Cooperation and assistance to other employees in their work.

5. Effective Communication and presentation skills.

6. Started sending professional-mails to get the assignments and submission of

reports of the tasks thus making them (Company guide, Chemists and

Retailers) aware the significance of this project in our professional life.

Critique and Analytical Review of

Pfizer’s StrategyPfizer has done quite well historically and analysis has revealed that they are

looking to position Themselves strategically for the future. But as we enter a new

era in the pharmaceutical industry With increased patent risks and lower marginal

product returns, pharmaceutical firms like Pfizer Must restructure their huge

organizational mass to reduce structural inefficiencies, cut costs Which is required to

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enable them compete better in the changing global environment. Due to it Massive

R&D push, Pfizer suffers a relatively high rate of discontinuation in pre-approval

Products and more focus are required to reduce resource wastage. Pfizer’s lack of

promising

Products in its early stage pipeline have left its combined pipeline relatively weaker.

This pipeline Deficit will not manifest for a number of years yet, and Pfizer is

perhaps well positioned than Most to ensure that it balances its R&D pipeline before

it becomes a cause for concern in future.

Pfizer’s imbalanced geographical presence (the US accounts for over 60% of

Pfizer’s market Area) may cause potential geographic limitations and can limit

revenue growth should US Demand weakens.

While the numbers of co-marketing and collaborative agreements, which Pfizer has

established, Are currently proving very favorable, agreements that geographically

limit Pfizer’s activities will Ultimately reduce its long term potential and must be

guarded against.

Finally, the economic emergence of mass production economies like India and

China into the Pharmaceutical fray will require new containment strategies. While

this is not an immediate Threat, over time the nature of competition will change and

the big pharmaceutical firms must Develop strategies to enable them reduce threats

and seize the opportunities that are created in Increasingly integrated global markets.

Going forwards, I recommend that Pfizer actions a resource\competence based

analysis of it’s Innate capabilities, those characteristics that offer Pfizer distinct

competitive advantage over its Industry rivals. There may be a role for using

‘McKinsey’s 7S Framework’ to determine the firm’s Core advantages.

On the period of internship I observed Job Descriptions and Responsibilities of the

Employees were Multi-tasking. The environment of the workplace is entirely

different From the concepts which I studied in books. So I found that to survive in

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the cut-throat Competitive era we need to develop multi-tasking skills along with

dynamic personality And strong communication skills.

Conclusion

The Pharmaceutical industry has a lot of yet untapped potential and it will be

interesting to see How the industry matures over the long term. Undoubtedly, the

long history and global expertise Of firms like Pfizer, GSK and Merck will stand

them in good stated to create and benefit from Emerging global opportunities.

Notwithstanding its strengths, complacency must be guarded Against because

smaller, agile and innovative firms are on the prowl and all it takes for the small

Upstarts are a Superdrug that can change the entire face of the industry. We’ve seen

it in happen In the Information & Communications industry, for all we know

pharmaceuticals may just be Next.

Recommendations

There are few recommendations from my side which can be beneficial for the

company

Employees should be trained according to the changing standards of the

Organization.

Company should conduct survey from time to time according to which

changes can

Be introduced in the organization to stay updated in the market.

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They should introduce creativity into the work, so that the employees can do

their Work passionately.

Employees should be more involved in decision making to become more

Differentiated.

Leanings from IP:

Learning beyond classroom

Platform for implementing theoretical concepts

Exposure to corporate culture

Experience under belt

Insight of actual strengths and weaknesses

Developing a network

Refinement of Career goals

Soft skill development

Impart Winning Edge

Feather in the cap as PPO

Documents

Internship Report on Remington Pharamacuetical Ltd