Multicenter Clinical Trial Virology Cold Chain Solutions,

Laboratory Diagnostics and Resistance Monitoring

knows your target

RSV VIROLOGY SERVICES

Other Viral Targets: · Influenza· Rhino / Entero· MERS· Zika· Dengue· Chickungunya· HCV / HBV· VZV· Rabies· and more

Q:

Q:

A:

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Can you quantify and sequence low viral load clinical samples directly ?

YES, our ultrasensitive qRT-PCR and Sequencing methods do.

Can you perform phenotypic resistance testing with RSV ?

YES, our ViroSpot assay detects phenotypic resistant (minority) variants.

Viral load: qPCR

00 3 6 9 1512 2118

0

2

1

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5

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Log 1

0 VP

/mL

Time (days after infection)

21 direct 21 frozen 26 direct 26 frozen

RSV A Long

CC VC Palivizumab (ng/mL) 2,000 1,000 500 250 125 62.5 31.25 15.6 7.8 3.9

1 2 3 4 5 6 7 8 9 10 11 12

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48h

24h

48h

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Spot

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nt (%

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Log (conc. inh.) (ng/mL)

Lot #1 Lot #2

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Tota

l int

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Log (conc. inh.) (ng/mL)

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• Ultrasensitive and Deep Sequencing

• RSV-A, RSV-B

• Clinical specimens with low viral load

• Direct sequencing of clinical specimens without virus culture

• Detection minority variants down to 1%

Q:

Q:

A:

A:

• Customized Virology Sampling Kits and Optimized Sampling Protocols.

• Global Cold Chain Sample Logistics.

• Courier service, On line tracking and tracing, 24/7 Help-Desk.

Viral load: qCulture Nasopharyngeal swab viral load

Is quantitative culture to detect infectious virus possible ?YES, our cold chain design allows detection of infectious viral load in culture and further phenotypic characterization.

Are RSV clinical samples stable in multicenter trial setting ?

YES, our cold chain and sampling protocols provide reproducibility and stability.

21 direct 21 frozen 26 direct 26 frozen

00 3 6 9 1512 2118

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Log 1

0 TCI

D50

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Time (days after infection)0

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8

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2 4 6 8qP

CR (L

og10

vp/

mL)

qCulture (Log10 TCID50/mL)

p< 0.01

tpt 1 tpt 2

VIROCLINICS BIOSCIENCESHeadquartered in Rotterdam, The Netherlands, Viroclinics Biosciences operates at a global level as the preferred virology testing laboratory for several of the top 10 biopharmaceutical companies. Viroclinics serves as a central and reference virology laboratory for phase I-IV clinical trials, and as a center of excellence for preclinical studies. Our clinical services include high throughput serology-, virology- and molecular assays, assay development services and clinical trial logistics services to support clinical sample handling and shipment, cold-chain management, tracking and tracing, training and reconciliation, and on line 24/7 helpdesk function. Assay innovation, customized protocols, and introduction of new tools keep our services and analyses up to date with the increasingly demanding criteria for registration of vaccines and antiviral drugs. Our expertise, experience, and consultative approach will meet the expected and go beyond by setting new standards. Please check whether we know your target and visit us at: www.viroclinics.com.

Meet the Expectedknows your target

Other Viral Targets: · Influenza· Rhino / Entero· MERS· Zika· Dengue· Chickungunya· HCV / HBV· VZV· Rabies· and more