I. GENERAL INFORMATION2014- American Society of Clinical Oncology (ASCO) 2015- Society of Surgical Oncology (SSO) 2015- American Society of Breast Surgeons (ASBS) Awards and Honors:

CURRICULUM VITAE I. GENERAL INFORMATION Name: Sarah Perry Thayer, MD, PhD Associate Director for Clinical Affairs and Physician-In-Chief, Fred & Pamela Buffett Cancer Center Chief, Division of Surgical Oncology Office: University of Nebraska Medical Center (UNMC), Division of Surgical Oncology, 986345 Nebraska Medical Center, Omaha, NE 68198-6345 E-Mail: [email protected] Telephone: 402-559-7298 Fax: 402-559-7900 Education:

1985 BA Earlham College, Richmond, IN 1987 MS Georgetown University, Washington, DC, Physiology and Biophysics 1991 MD University of Virginia School of Medicine, Charlottesville, VA 1994-1999 PhD Cornell University Graduate School of Medical Sciences, Dept. of

Neuroscience, New York, NY. (Thesis work done in the laboratory of Dr. Kathleen Scotto, Department of Eukaryotic Transcription, Memorial Sloan-Kettering Cancer Center, Rockefeller Research Laboratory)

Continuing Education: 2013-2014 Executive Education Program, Managing Health Care Delivery, Harvard Business School, Boston, MA Postdoctoral Training:

Internship and Residencies:

1991-1992 General Surgery Internship, Massachusetts General Hospital (MGH), Boston, MA

1992-1994 General Surgery Junior Resident, MGH, Boston, MA 1994-1998 Surgical Research Fellow, Cornell University/Memorial Sloan-Kettering

Cancer Center, New York, NY 1998-2000 General Surgery Senior Resident, MGH, Boston, MA

Fellowships:

1994-1995 The Varazted H. Kazanjian Research Fellowship, MGH, Boston, MA 1995-1999 Memorial Sloan-Kettering Cancer Center, New York, NY 2000-2001 Chief of Churchill Service, Instructor in Surgery, additional post-doctoral

training position focused on complex surgical oncology procedures, MGH, Boston, MA

Licensure and Certification:

1991- Commonwealth of Massachusetts License (No. 203874)

Sarah P. Thayer, M.D., Ph.D. Page 2

1994-1996 State of New York License (No. 197481) 2001-2012 American Board of Surgery Certification (No. 46560) 2010-2022 American Board of Surgery Recertification (No. 046560) 2014- State of Nebraska License (No. 27762)

Academic Appointments:

2001-2004 Instructor in Surgery, Harvard Medical School 2004-2009 Assistant Professor of Surgery, Harvard Medical School 2010-2014 Associate Professor of Surgery, Harvard Medical School 2014- Merle M. Musselman Centennial Professor of Surgery, UNMC 2014- Professor, Eppley Institute for Research in Cancer, UNMC, Joint Appointment

Hospital Appointments:

2000–2001 Chief, Surgical Services, Assistant in Surgery, MGH, Boston, MA 2001–2003 Assistant in Surgery, Surgery Service, MGH, Boston, MA 2003-2009 Assistant Surgeon, Surgery Service, MGH, Boston, MA 2008-2014 Director, Pancreatic Biology Laboratory, MGH, Boston, MA 2009-2014 Associate Visiting Surgeon, Surgery Service, MGH, Boston, MA 2014-2016 Visiting Scientist, MGH, Boston, MA 2014- Active Academic Staff Surgeon, Nebraska Medicine, Omaha, NE 2014- Chief, Division Surgical Oncology, Nebraska Medicine, Omaha, NE 2014- Physician-In-Chief and Associate Director for Clinical Affairs for the Fred &

Pamela Buffett Cancer Center (F&PBCC), Nebraska Medicine, Omaha, NE Major Administrative Responsibilities:

2000-2001 Organized all weekly teaching conferences, including Surgical Grand Rounds, Oncology Conference, Gastrointestinal Conference, and Thoracic Conference, MGH

2008-2014 Director, Pancreatic Biology Laboratory, MGH, Boston, MA 2014- Director, Thayer Research Laboratory, UNMC, Omaha, NE 2014- Chief, Division Surgical Oncology, Nebraska Medicine, Omaha, NE 2014- Physician-In-Chief and Associate Director for Clinical Affairs for the F&PBCC,

Nebraska Medicine, Omaha, NE 2014- Executive Committee for the Cancer Center Project, Nebraska Medicine,

Omaha, NE 2014- Cancer Center Senior Leadership Council, Nebraska Medicine, Omaha, NE 2014- Cancer Center Governance Committee, Nebraska Medicine, Omaha, NE 2014- Chancellor’s Diversity Advisory Steering Committee, Nebraska Medicine,

Omaha, NE 2014 Medical Director, Comprehensive Breast Cancer Service, UNMC, Omaha, NE 2015- Clinical Operations Council, Nebraska Medicine, Omaha, NE 2015- Cancer Clinical Operations Group, Nebraska Medicine, Omaha, NE 2015- Patient Access Oversight Council, UNMC, Omaha, NE 2016- Chair, Women’s Cancer Center Council, UNMC, Omaha, NE 2016- Lead, F&PBCC Electronic Filing Committee, UNMC, Omaha, NE


2016- F&PBCC Strategic Events Committee, UNMC, Omaha, NE

Major Committee Assignments:

UNMC and F&PBCC:

2016- Chair, Women’s Cancer Center Council 2016- Member, F&PBCC Strategic Events Committee 2016- Member, F&PBCC Utilization Management Committee 2016- Lead, F&PBCC Electronic Filing Committee 2016- Member, F&PBCC Donor Naming & Public Wayfinding/Signage Committee 2016- Member, F&PBCC Senior Clinical & Operations Advisory Committee 2015- Internal Advisory Board (IAB) 2016 Pancreatic SPORE 2015- Internal Advisory Board (IAB) 2016 GI SPORE 2015- Clinical Operations Council 2015- Patient Access Oversight Council 2015- Cancer Clinical Operations Group 2015- Cancer Prevention and Control Program 2014 - Cancer Center Governance Committee 2014- Practice Committee 2014- Executive Committee for the Cancer Center Project 2014- Healing Arts Program Committee 2014- Surgical Subject Matter Experts Team 2014- Intensive Care Unit Subject Matter Experts Team 2014- Cancer Center Senior Leadership Council 2014- Chancellor’s Diversity Advisory Steering Committee 2014-2015 Academic Variable Compensation Committee Massachusetts General Hospital: 2001-2014 Member, Executive Committee, Women’s Health Coordinating Council 2003-2005 Member, Executive Committee on Research Subcommittee on Review of Research Proposals, Fund for Medical Discovery Study Section 2004, 2011 Member, Physician Nominating Committee of the MGH Physician

Organization (MGPO) Executive Committee 2005-2014 Member, Surgical Research Council 2005-2014 Member, Resident Training and Education Committee, Surgical Research

Council 2007-2014 Associate Faculty, Center for Human Genetic Research, MGH & Harvard

Medical School 2008-2009 Member, Physician Nominating Committee of the MGPO Executive

Committee 2008-2014 Member, Clinical Referral Management Improvement Initiative Steering

Committee 2011-2014 Fellowship Award Committee, MGH Department of Surgery

Sarah P. Thayer, M.D., Ph.D. Page 4 Harvard Medical School:

2004-2008 Member, Committee on Admissions 2005-2009 Faculty Advisor, Oncology Interest Group Research Committee

Affiliated Institutions:

2002-2012 PI, Project 1, NIH GI SPORE Project, “Improved Peri-Operative Staging of Pancreatic Cancer,” Dana-Farber Cancer Institute (DFCI)

2003-2014 Member and Principal MGH Scientific Contact, DFCI/Harvard Cancer Center, Gastrointestinal Cancer Program, Pancreatic Program Working Group

2007-2014 Member, DFCI Gastrointestinal Cancer Center Clinical Research Committee 2006-2014 Director, BioBank Core, NIH Consortium Project, “Genetics and Biology of

Pancreatic Duct Adenocarcinoma” (DFCI/MD Anderson)

Regional/National:

2008-2014 Guidelines Panel, National Comprehensive Cancer Network (NCCN) 2008-2014 Program Committee, Pancreas Club 2008-2011 Committee on Social and Legislative Issues, Society of University Surgeons 2008-2014 Scientific Advisory Board, The Lustgarten Foundation for Pancreatic Cancer

Research 2009- Strategic Planning Committee, American Pancreatic Association (APA) 2012- Scientific Review Board, The Lustgarten Foundation for Pancreatic Cancer

Research 2013- Clinical and Translational Cancer Research Committee, Cancer Prevention &

Research Institute of Texas 2015 Pancreatic Cancer Action Network-AACR Career Development Awards

Scientific Review Committee 2015- NCCN Panel for Pancreatic Adenocarcinoma

International:

2008- International Cancer Genome Consortium Community: 2008-2014 Advisor, Students on the Forefront of Science Program, Brooks School Editorial Boards:

2007-2014 Editorial Board, Pancreatology Professional Societies:

1998- American Medical Association (AMA) 1998- MGH Surgical Alumni Society 2000- APA 2002- American Association for the Advancement of Science (AAAS) 2002- International Association of Pancreatology (IAP) 2002- New York Academy of Sciences 2002- Society of Laparoendoscopic Surgeons (SLS)


2005- American College of Surgeons (ACS), Fellow 2006- American Hepato-Pancreato-Biliary Association (AHPBA) 2006-2014 NCI Cancer and Leukemia Group B (CALGB) 2006- Society of University Surgeons 2006- Boston Pancreas Study Group 2007- Boston Surgical Society 2007- Pancreas Club 2009- New England Surgical Society 2012- Society for Surgery of the Alimentary Tract (SSAT) 2014- American Society of Clinical Oncology (ASCO) 2015- Society of Surgical Oncology (SSO) 2015- American Society of Breast Surgeons (ASBS)

Awards and Honors: 1989 Alpha Omega Alpha, University of Virginia School of Medicine 1991 Sandoz Award in recognition of superior academic achievement and

contribution to health care 1991 Janet M. Glasgow Memorial Award of the American Medical Women’s

Association 1991 Valedictorian, University of Virginia School of Medicine 2000 Resident/Fellow Award for Excellence in Clinical Teaching in Surgery,

Harvard Medical School 2002 Phillip H. Meyers, MD, Annual Research Grant (award) from the Society of

Gastrointestinal Radiologists, for Visionary Research in Medical Imaging (Acute Mesenteric Ischemia) using Multi-Detector CT and CT Angiography

2003 Hirshberg Award for Best Presentation, Annual Meeting APA, Chicago, IL 2004 Investigator Award for Outstanding Publication (Nature 2003; 425 [Oct. 23]:851-

856), Santa Cruz Biotechnology 2002-2014 W. Gerald Austen Scholar in Academic Surgery, MGH and Harvard Medical

School 2014- Merle M. Musselman Centennial Professor of Surgery, UNMC 2016 NESS Paper of the Year Award for, “Prognosis of invasive intraductal papillary

mucinous neoplasms depends on histological and precursor epithelial subtypes”

2017 UNMC Distinguished Scientist/New Investigator Award for 2016. Ceremony held on 01/17/2017

II. RESEARCH, TEACHING, AND CLINICAL CONTRIBUTIONS A. Current Research Activities: The focus of the Thayer laboratory has been to investigate the genes that may contribute to

the initiation, progression and regulation of pancreatic cancer. My early work focused on the early and late role of a developmental gene, Shh, in pancreatic cancer (Nature 2003). This work revealed that Shh is upregulated early in pancreatic carcinogenesis and in response to chronic inflammatory injury. Although Shh plays an important later role in the biology of pancreatic cancer, it has an equally important early role as an initiator, driving the formation of mucinous ductal lesions resembling early precursor lesions to cancer. My lab has since


focused further on characterizing the cell of origin responsive to Shh and the mechanism behind pancreatic regeneration in response to inflammatory injury, and how these may contribute to the formation of pancreatic cancer precursor lesions, and ultimately to cancer. My group was the first to categorize and classify three distinct forms of metaplastic ductal lesions formed in the regenerative response to chronic inflammation (PNAS 2007) and their role in regeneration and cancer. Using a chronic inflammatory injury model in combination with in vivo lineage tagging, we demonstrated that the beta cell (PNAS 2007) and acinar cell (Gastroenterology 2007) compartments regenerate by self-renewal. We went on to demonstrate that these compartments do not transdifferentiate and do not contribute to the formation of metaplastic ductal lesions, and thus are an unlikely cell of origin for pancreatic cancer. Most recently, investigation of Shh has called our attention to a novel pancreatic epithelial compartment which we have termed pancreatic duct glands (PDGs) (Gastroenterology 2010). This work shows that PDGs are mucinous compartment with a distinct molecular signature, expressing many developmental genes believed to mark stem cell compartments. Subsequent work revealed that PDGs are a unipotential epithelial progenitor stem cell niche (Stem Cell Res 2015) that undergoes a Shh-mediated mucinous gastrointestinal metaplasia resembling certain features of pancreatic cancer precursor lesions. Work recently accepted suggests that the PDGs may be the compartment of origin for pancreatic cystic neoplasm (Gastroenterology).

B. Patents: 1. Method for Inducing Beta Cell Neogenesis from Epithelial Cells

Q&B Ref: 125141.00165 MGH Ref: 3767.02

C. Grants: Active Title: Targeting the Metabolic Basis of Cachexia in Pancreatic Cancer ID Number: 1R01CA210439-01A1 Funding Agency: DHHS/NIH/NCI Project Period: 2016-2021 Total Dollars: $2,270,325 Role: Co-Investigator, PI Pankaj K. Singh, PhD Title: Pathobiological Implications of Secretory Mucin MUC5AC in Pancreatic

Cancer ID Number: Funding Agency: DHHS/NIH/NCI Project Period: 2017-2020 Total Dollars: $138,540 Role: Co-Investigator, PI Sukhwinder Kaur, PhD Title: Multimodal contrast agents for preoperative and intraoperative imaging ID Number: 2017-41 Funding Agency: NE DHHS LB506 Project Period: 2016-2017 Total Dollars: $50,000 Role: Co-Investigator, PI Aaron M. Mohs, PhD

Sarah P. Thayer, M.D., Ph.D. Page 7 Title: F&PBCC Support Grant ID Number: P30CA036727 Funding Agency: DHHS/NIH/NCI Project Period: 2016-2021 Total Dollars: $35,672,339 Role: Program Leader GI Cancer Program (GICP) Title: Metabolic Regulation of Tumor Progression, Metastasis and

Chemoresistance by SIRT5/ELK3 Signaling in Pancreatic Cancer ID Number: Funding Agency: DHHS/NIH Project Period: 2017-2022 Total Dollars: $2,883,905 Direct Costs: $1,916,215 Role: Co-Investigator, PI Pankaj K. Singh, PhD Title: CTCs as predictors of primary and metastatic tumor genetics and biology

of PDAC ID Number: 1R21CA201886-01 Funding Agency: DHHS/NIH/NCI Project Period: 09/01/2015 – 08/31/2017 Total Dollars: $413.875.00 Direct Cost: $413,875.00 Role: PI Title: Polymeric Nanomedicines of Hedgehog Inhibitor and miRNA for

Treating Pancreatic Cancer ID Number: 1R01GM113166-01A1 Funding Agency: DHHS/NIH/NIGMS Project Period: 2015 - 2019 Total Dollars: $1,424,348 Direct Cost: $237,000 Role: Co-Investigator, PI Ram Mahato, PhD Title: PDG Links Stem Cell Niche to Pancreatic Epithelial Renewal, Repair and

Cancer ID Number: 5R01CA169086-03 Funding Agency: DHHS/NIH/NCI Project Period: 2013 - 2018 Total Dollars: $1,363,661 Direct Cost: $207,500 Role: PI Title: LB595 Tobacco Tax Center Research Grant Funding Agency: NE DHHS - LB595

Sarah P. Thayer, M.D., Ph.D. Page 8 Project Period: 2015 - 2019 Total Dollars: $30,004,831 Direct Cost: $1,300,000 Role: Co-Investigator, PI Ken Cowan, MD, PhD Pending Title: Troika for the Diagnosis/Prognosis of Pancreatic Cancer ID Number: Funding Agency: Sanguine Diagnostics and Therapeutics, Inc. Project Period: 2017-2019 Total Dollars: $764,000 Direct Cost: $507,641 Role: Co-Investigator, PI Sukhwinder Kaur, PhD Title: Pancreatic Cancer Metastasis ID Number: Funding Agency: DHHS/NIH Project Period: 2017-2022 Total Dollars: $9,776,795 Direct Cost: $6,500,000 Role: Co-Investigator, PI Surinder Batra Title: Role of PD2/Paf1 in Pancreatic Acinar to Ductal Metaplasia ID Number: Funding Agency: DHHS/NIH Project Period: 2017-2022 Total Dollars: $450,389 Direct Cost: $300,000 Role: Co-Investigator, PI Moorthy Palanimuthu Ponnusam, PhD Title: Lutetium-177 labeled genetically-engineered theranostics against

pancreatic cancer ID Number: 1R01CA206215-01 Funding Agency: DHHS/NIH/NCI Project Period: 2016 - 2021 Total Dollars: $2,253,715 Direct Cost: $1,500,000 Role: Co-Investigator, PI Maneesh Jain, PhD Submitted Title: Isolation and genetic characterization of breast cancer circulating tumor

cells Funding Agency: NIH/NIGMS “Great Plains IDeA CTR” Project Period: 03/01/2017-02/28/2018 Total Dollars: $50,000 Direct Cost: $50,000 Role: PI

Sarah P. Thayer, M.D., Ph.D. Page 9 Title: Isolation and genetic characterization of circulating tumor cells as

predictive biomarkers in high-risk early stage breast cancer Funding Agency: NIH/NCI Project Period: 12/01/2017 – 11/30/2019 Total Dollars: $413,875 Direct Cost: $275,000 Role: PI Submitted not funded: Title: Variant-specific functions of DPYSL3 in pancreatic cancer. Applications

for Collaborative Pilot Project Grants-NCCS, Years 3-4 of Phase III Funding Agency: DHHS/NIH/NCI Project Period: 08/17/2015 – Total Dollars: $100,000 Direct Cost: $100,000 Role: PI Completed: Title: UNMC Eppley Cancer Center Support Grant ID Number: 3P30CA036727-29S1 Funding Agency: DHHS/NIH/NCI Project Period: 2011-2016 Total Dollars: $34,613,080 Direct Costs: $1,059,259 Role: Program Leader-PI D. Teaching/Invited Lectures:

2001 Lecture, “Gall bladder and bile duct cancer,” Chief's Rounds, Department of Surgery, MGH, Boston, MA

04/11/2002 Lecture, “Lymphangioma and lymphatic malformation,” Grand Rounds, Department of Surgery, MGH/ Harvard Medical School, Boston, MA

05/09/2002 Lecture, “Abnormal expression of developmental signaling pathways in pancreatic cancer: The role of Sonic hedgehog,” Grand Rounds, Department of Surgery, MGH, Boston, MA

2002-2014 Preceptor, Introduction to Clinical Medicine — MGH Department of Surgery, Patient-Doctor II Course for second-year Harvard Medical School medical students, Boston, MA

10/30/2002 Lecture, “Abnormal expression of developmental signaling pathways in pancreatic cancer: The role of Sonic hedgehog,” Melton Laboratory of Molecular Embryology, Department of Molecular and Cell Biology, Harvard University, Boston, MA

11/01/2002 Lecture, “Abnormal expression of developmental signaling pathways in pancreatic cancer: The role of Sonic hedgehog,” Gastrointestinal SPORE Group Series, MGH, Boston, MA


09/04/2003 Lecture, “Sonic hedgehog and the genetics of pancreatic cancer,” Halsted Society, 77th Annual Meeting, Boston, MA

09/30/2003 Lecture, “The ICU consult for abdominal pain,” Post-graduate course in general surgery, Harvard Medical School Department of Continuing Education (presented by the Department of Surgery, MGH), Boston, MA

10/21/2003 Discussant, Surgical Oncology II Session, Surgical Forum Program, 89th Annual Clinical Congress, ACS, Chicago, IL

11/04/2003 Lecture, “Pancreatic cancer: Future challenges for the clinician and scientist,” Pancreatic Think Tank, DFCI, Boston, MA

11/18/2003 Lectures: (1) “Pancreatic cancer: Future challenges for the clinician and scientist;” (2) “Sonic hedgehog and pancreatic cancer,” DFCI/Harvard Cancer Center, Gastrointestinal Cancer Program/Pancreatic Program Working Group, Boston, MA

03/30/2004 Invited speaker, “A translational approach to pancreatic cancer therapy,” session, “New concepts in organ-site research” (Ronald DePinho and Margaret Tempero, Co-Chairs) 95th Annual Meeting AACR, Orlando, FL

04/08/2004 Lecture, “Abdominal catastrophes in the ICU patient,” Grand Rounds,

Department of Surgery, MGH, Boston, MA 05/16/2004 Invited speaker, “Sonic hedgehog and pancreatic cancer,” Digestive

Disease Week (DDW), New Orleans, LA 09/27/2004 Post-graduate course in general surgery, Harvard Medical School

Department of Continuing Education (presented by the Department of Surgery, MGH), Boston, MA

11/18/2004 Lecture, “Pancreatic cancer: Unmasking the mysteries,” Surgical Grand Rounds, Division of General Surgery, MGH, Boston, MA

12/2-3/2004 Invited speaker, “Pancreatic cancer in mice and men: The Penn Workshop,” sponsored by NCI Mouse Model of Human Cancer

Consortium (MMHCC) and University of Pennsylvania, Philadelphia, PA 04/20/2005 Invited Speaker, “Developmental pathways and pancreatic cancer,”

session, New Concepts in Organ-Site Research: Toward Effective Management of Pancreatic Cancer, 96th Annual Meeting AACR, Anaheim, CA

05/17/2005 Co-chair (with Steven Leach), Research Symposium, “PANIn lesions,” American Gastroenterological Association/DDW, Chicago, IL 06/11/2005 Invited speaker, “Developmental genes and pancreatic cancer,” MGH

Surgical Society Reunion, Boston, MA 08/11/2005 Lecture, “The role of developmental genes in pancreatic cancer,” Grand

Rounds, Department of Anesthesia and Critical Care, MGH, Boston, MA 09/24/2005 Invited speaker, “Hedgehog and pancreatic cancer,” 5th Annual Dartmouth

Conference on Liver, Pancreas, and Biliary Disease, Dartmouth-Hitchcock Medical Center, Lebanon, NH

10/04/2005 Co-chair (with Ed Whang), Oral Session 4: Pancreatic Cancer II, 36th Annual Meeting, APA, Chicago, IL


03/11/2006 Invited speaker, “Targeting developmental signaling pathways,” Basic Science Update Symposium: Translational Biotherapies in HPB Malignancy, AHPBA Annual Meeting, Miami Beach, FL

(Same meeting) Discussant, “Pilot study of novel mouse model of human pancreas adenocarcinoma,” Paper Session IV: Basic Science

06/26-27/2006 Invited speaker, “Developmental genes and pancreatic cancer,” Lustgarten Foundation for Pancreatic Cancer Research, 8th Annual Scientific

Conference, “Pancreatic Cancer: Early Detection and Novel Therapies,” Chapel Hill, NC

09/19/2006 Invited speaker, “Pancreatic cancer,” MGH/ Harvard Medical School postgraduate course in general surgery, “Advances in Gastrointestinal Surgery,” Boston, MA

10/09/2006 Co-moderator (with Ed Whang), surgical forum session, “Alimentary tract I: Stomach, hepatobiliary and pancreas,” 92nd Clinical Congress, ACS, Chicago, IL

10/15/2006 Keynote speaker, 1st Boston Walk for Pancreatic Cancer, Lustgarten Foundation for Pancreatic Cancer Research, Boston, MA

04/21/2007 Moderator, Basic Science Session and Biliary II Session, AHPBA Annual Meeting, Las Vegas, NV

05/03/2007 Invited speaker, “The surgical management of early pancreatic cancer and/or lesions with malignant potential,” MGH Inaugural Pancreatic-Biliary Day, MGH Digestive Health Care Center, Boston, MA

06/06/2007 “The surgical management of pancreatic cancer,” Chief’s Rounds, Department of Surgery, MGH, Boston, MA

10/03/2007 Invited speaker, “What is the cell of origin of pancreatic neoplasia: Acinar, islet, duct or stem cells?” APA/Lustgarten Foundation Symposium “Stem Cells, the Pancreas, and Pancreatic Cancer,” following the APA Annual Meeting, Chicago, IL

10/03/2007 Co-moderator (with Steven Leach, MD), session, “Model Organisms,” APA/Lustgarten Foundation Symposium, “Stem cells, the pancreas, and pancreatic cancer,” following the APA Annual Meeting, Chicago, IL

04/13/2008 Genetics and Biology of Pancreatic Duct Adenocarcinoma – “Core C: Biobank core,” Pancreatic Ductal Adenocarcinoma (PDAC) P01 Program Retreat, Annual Meeting AACR, San Diego, CA

05/14/2008 “Pancreatic cancer: From bench to bedside,” Friends of the MGH Cancer Center, Boston, MA

05/15/2008 “Cell of origin of pancreatic cancer,” symposium, “Gastrointestinal Cancer Research at Harvard,” sponsored by DFCI/Harvard Cancer Center Gastrointestinal Malignancies Program, Harvard Club, Boston, MA

10/03/2008 “Pancreatic cancer: Collaborative opportunities” (Representing DFCI/Partners P01 Project on Pancreatic Adenocarcinoma, BioBank Core)

Scientific Advisory Board meeting, Genomics and Biocomputing Platforms, International Human Cancer Genome Project, Ontario Institute for Cancer Research, Toronto, Canada

11/08/2008 Moderator of sessions, “Early Events in Disease Development” and “Animal Models of Chronic Pancreatitis and Pancreatic Cancer,“


APA/Lustgarten Foundation Symposium, “The Chronic Pancreatitis to Pancreatic Cancer Continuum,” following the APA Annual Meeting, Chicago, IL

05/22/2009 “Pancreatic cancer: Possible research strategies and solutions,” Department of Surgery, Medical College of Wisconsin, Milwaukee, WI 11/04/2009 “Pancreatic cancer: Enrichment and advances in sample acquisition” International Cancer Genome Consortium (ICGC) Meeting, Honolulu, HI 11/07/2009 “Invasive IPMC vs. PDAC: Are they biologically and genetically distinct?”

Mini-symposium 5 on IPMN, APA & Japan Pancreas Society, Honolulu, HI 11/14/2009 “Pancreatic cancer: Approaches to future therapies,” course, “Pancreatic

Cancer: Early Diagnosis and Innovative Treatments,” Washington University School of Medicine/Siteman Cancer Center, St. Louis, MO

03/06/2010 “Potential drugs and targets along the hedgehog signaling cascade in pancreatic cancer and other solid tumors,” session, “Potential Therapeutic Targets for Clinical Trials,” 63rd Cancer Symposium, SSO, St. Louis, MO

03/21-23/2010 Invited participant, Third Scientific Workshop of the ICGC, Madrid, Spain 05/10/2010 Presentation, “The role of Shh in pancreatic metaplasia and malignancy,” 11th Annual Symposium, “The Biology of Pancreatic Development,

Regeneration and Malignancy,” NIH Center for Molecular Studies in Digestive and Liver Diseases and the Penn/CHOP Center for Digestive, Liver and Pancreatic Medicine, Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA

11/04/2010 Moderator of session, “Pancreatic Cancer,” APA Annual Meeting, Chicago, IL

05-09/2011 “Duct cell progenitors,” research symposium, “Pancreatic Stem Cells” American Gastroenterological Association, DDW, Chicago, IL 06/14/2011 “Hedgehog signaling,” Harvard Catalyst Clinical and Translational Science

Center, Harvard Medical School, Boston, MA 10/26/2011 “Observation: Which pancreatic cystic lesions can be safely followed?” Session, “Management of Cystic Lesions of the Pancreas,” 97th Annual

Clinical Congress, ACS, San Francisco, CA 11/04/2011 Moderator of session, “Basic and Clinical Pancreatic Cancer,” APA Annual

Meeting, Chicago, IL 11/08/2012 Invited speaker, “Pancreatic cancer risks and solutions,” Dr. Oz Show

broadcast, “Your Biggest Cancer Risks: The Biggest Solution,” New York, NY

11/12-15/2012 Invited participant, 3rd Annual Meeting World Circulating Tumor Cells (CTC) Summit, Boston, MA

02/13/2013 Invited speaker, “The capture, growth and genetic analysis of CTC in PDAC,” session chair, “Circulating Tumor Cells: Future of Cancer Management,” Cambridge Healthtech Institute Molecular Medicine Tri-Conference, San Francisco, CA

04/22/2013 Invited speaker, “Diagnosis can be achieved by screen cell CTC cytology” Screen Cell, Paris, France


04/24/2013 Invited speaker, “The capture, growth and genetic analysis of CTC in PDAC,” session, “Latest Insights on Capture, Enumeration and Characterization,” World CTC, April 24-25, Berlin, Germany

05/13/2013 Invited speaker, “Pancreatic duct glands (PDG), an epithelial progenitor compartment important in regeneration and cancer,” Harvard Pancreas Group Dinner, Harvard Club, Boston, MA

07/21-26/2013 Invited speaker, “Pancreatic duct glands (PDG): An epithelial progenitor stem cell compartment important in regeneration and cancer,” Gordon Research Conference: Pancreatic Diseases 2013, Mount Holyoke College, South Hadley, MA

10/2-3/2014 “Update in the management of pancreatic cystic neoplasms,” 9th Annual Fall Midwest Thoracic and GI Oncology Conference, Omaha, NE

10/26-30/2014 Co-moderator, “Necrotizing pancreatitis: The devil is in the details,” ACS Clinical Congress, San Francisco, CA

11/05/2014 Co-presenter, “Biomarkers for early detection,” Early Detection of Sporadic Pancreatic Cancer Summit Conference, Big Island, HI

11/07/2014 Moderator, “Innovation in pancreatic cancer treatment,” APA 45th Anniversary Meeting, Big Island, HI

03/03/2015 Testimony before the Appropriations Committee of the Nebraska Legislature, Lincoln, NE

07/08/2015 UNMC Grand Rounds, Service Introduction by Chiefs, Omaha, NE 09/11-15/2015 Presentation at the 7th Muscat International Oncology and 4th Oman Cancer

Association Conference, Muscat, Oman 09/13/2015 Invited Speaker, “Breast cancer is a global disease: Is global screening

appropriate for all?” 7th Muscat International Oncology & 4th Oman Cancer Association, Muscat, Oman

10/09/2015 Invited Speaker, “Operative treatment for pancreatic cancer patients with metastatic disease,” 10th Annual Fall Midwest Thoracic and GI Oncology Conference, Omaha, NE

03/5/2016 Invited Speaker, Winter Workshop of the Nebraska State Assembly for Surgical Technologists. College of Public Health, UNMC, Omaha, NE

07/13/2016 Invited Speaker, 7th Extraordinary Innovations and Emerging Trends in Transplantation and Oncology from Nebraska Medicine, Optum Health Conference. Presentation entitled, “Current Management of Breast Cancer: A Multidisciplinary Approach,” Century Link Center, Omaha, NE

08/09/2016 Invited Speaker, Telehealth Presentation: “Update of the Fred & Pamela Buffett Cancer Center,” Omaha, NE

08/15/2016 Presentation concerning the Gastrointestinal Cancer Program to attendees at the Senior Leadership Council Retreat, Omaha, NE

08/15/2016 Presentation concerning the Strategic Investment Group (SIG) to attendees at the Senior Leadership Council Retreat, Omaha, NE

08/16/2016 Presentation concerning the Women’s Cancer Center for the University of Nebraska Foundation, Happy Hollow Country Club, Omaha, NE

10/07/2016 Presentation at the GI Oncology Conference, Scott Conference Center, University of Nebraska Omaha, Omaha, NE

10/24/2016 Presentation for the Board of Counselor’s Meeting, UNMC, Omaha, NE


11/30/2016 Introduction for the Miller Lecture and Dr. Douglas Evans 12/13/2016 Breast Education Presentation to the 9 North Nurses at UNMC 03/31/2017 Presentation at the 69th Annual Meeting & Scientific Assembly of the

Nebraska Academy of Family Physicians (NAFP), La Vista, NE Teaching Awards:

2000 Resident and Fellow Award for Excellence in Clinical Teaching in Surgery, Harvard Medical School

Mentoring/Advising:

2002–2005 HMS David E. Rosow, MD 2003–2005 Research Fellow Oliver Strobel, MD (Heidelberg University) 2004–2006 Research Fellow (T32) Denise Long, MD (Georgetown University) 2005–2007 Research Fellow Elena Rakhlin, MD (Harvard University) 2005–2007 Research Fellow (T32) Janivette Alsina, MD, PhD (UMDNJ) 2006 Summer student Steven Poon (Tufts University 2008) 2006–2007 HMS Yin Pun (Rex) Hung (2009) 2006–2008 Research Fellow Jennifer LaFemina, MD (UCLA) 2006–2008 Research Fellow Stefan Fritz, MD (Heidelberg University)

2007–2009 Research Fellow Vasiliki Androutsopoulos, MD (Venezuela) 2007–2010 Research Fellow Dirk Bausch, MD (University of Freiburg) 2008 Summer student Michael Hendrickson (Brooks School ’09, program “Students on the Frontiers of Science”) 2008–2009 Research Fellow Avais M. Chatha, MD (University of Lahore) 2009 Summer student Brian Bernier (Brooks School ’10, program

“Students on the Frontiers of Science”) 2009–2011 Research Fellow Joo Kyung Park, MD (Seoul, Korea) 2009–2014 Research Fellow Andrew S. Liss, PhD (University of Texas, Austin) 2010-2012 Research Fellow Nakul Valsangkar, MD (New Delhi, India) 2010–2013 Research Fellow Junpei Yamaguchi, MD (Nagoya, Japan) 2010 Summer student Cheng Hui Bryan Chang (Brooks School ’11,

program “Students on the Frontiers of Science”) 2011 Research Fellow Birte Kulemann, MD (University of Freiburg) 2012 Summer student Cécile Harmange (Brooks School ’12, program

“Students on the Frontiers of Science”) 2012–2013 Research Fellow Jiahua Zhou, MD, PhD (Nanjing, China) 2012 Research Fellow Naoki Ikenaga, MD, PhD (Fukuoka, Japan) 2012 Summer student Lorena Ceci, BS (University of Massachusetts

Medical School) 2012 Summer student Gabriel DiNatale (undergraduate, Dickinson

College) 2012 Intern Alexandra Sontheimer (medical student, University

of Freiburg) 2013-2014 Intern Curtis Adams (undergraduate, Tufts University) 2013–2014 Research Fellow Akifumi Nakagawa, MD, PhD (Nagoya, Japan)


2013 Intern Joachim Vaturi (Lycée Français de New York) 2013-2014 Research Fellow James Perkins, MD (Pennsylvania State University) 2013-2014 Research Fellow Yinshi Huang, MD (Shanghai, China) (starting

11/2013) 2014-2015 PhD Sanjib Chowdhury, PhD (UNMC) 2014- PhD Dulce Maroni Veiga, PhD (UNMC) 2014- Post-doc Pinaki Mondal, PhD (University of Calcutta) 2014- Post-doc Xiang Liu, PhD (UNMC) 2015- MD/PhD Candidate Richard Sleightholm (UNMC) 2015- MD/PhD Candidate Beth Clymer (UNMC) 2016- MD/PhD Candidate Andrew C. Cannon (UNMC) 2016- PhD Candidate Jaime Abrego, (UNMC) 2016- MD/PhD Candidate Cassie Liu, (UNMC)

III. BIBLIOGRAPHY Original Articles: 1. Dubois M, Chen J, Thayer SP, Narang P, Kaufman J, Hatendi A. Pharmacokinetics of alfentanil continuous IV infusion in neurosurgical patients. Anesth Analg 1987; 66:S44. 2. Thayer SP, Fernandez-del Castillo C, Balcom JH, Warshaw AL. Complete dorsal

pancreatectomy with preservation of the ventral pancreas: a new surgical technique. Surgery. 2002;131(5):577-80. PMID: 12019413.

3. Fernandez-del Castillo C, Targarona J, Thayer SP, Rattner DW, Brugge WR, Warshaw AL. Incidental pancreatic cysts: clinicopathologic characteristics and comparison with symptomatic patients. Arch Surg. 2003;138(4):427-3; discussion 33-4. doi: 10.1001/archsurg.138.4.427. PMID: 12686529; PMCID: PMC4403874.

4. Thayer SP, di Magliano MP, Heiser PW, Nielsen CM, Roberts DJ, Lauwers GY, Qi YP, Gysin S, Fernandez-del Castillo C, Yajnik V, Antoniu B, McMahon M, Warshaw AL, Hebrok M. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature. 2003;425(6960):851-6. doi: 10.1038/nature02009. PMID: 14520413; PMCID: 3688051.

5. Thayer S. The emerging role of the hedgehog signaling pathway in gastrointestinal cancers. Clin Adv Hematol Oncol. 2004;2(1):17, 20, 63. PMID: 16163153.

6. Salvia R, Fernandez-del Castillo C, Bassi C, Thayer SP, Falconi M, Mantovani W, Pederzoli P, Warshaw AL. Main-duct intraductal papillary mucinous neoplasms of the pancreas: clinical predictors of malignancy and long-term survival following resection. Ann Surg. 2004;239(5):678-85; discussion 85-7. PMID: 15082972; PMCID: 1356276.

7. Warshaw AL, Thayer SP. Pancreaticoduodenectomy. J Gastrointest Surg. 2004;8(6):733-41. doi: 10.1016/j.gassur.2004.03.005. PubMed PMID: 15358336; PMCID: 3811050.

8. Alsfasser G, Antoniu B, Thayer SP, Warshaw AL, Fernandez-del Castillo C. Degradation and inactivation of plasma tumor necrosis factor-alpha by pancreatic proteases in experimental acute pancreatitis. Pancreatology: official journal of the International Association of Pancreatology. 2005;5(1):37-43; discussion doi: 10.1159/000084489. PMID: 15775698; PMCID: PMC3817566.

9. Ferrone CR, Kattan MW, Tomlinson JS, Thayer SP, Brennan MF, Warshaw AL. Validation of a postresection pancreatic adenocarcinoma nomogram for disease-specific


survival. J Clin Oncol. 2005;23(30):7529-35. doi: 10.1200/JCO.2005.01.8101. PMID: 16234519; PMCID: 3903268.

10. Rosow DE, Sahani D, Strobel O, Kalva S, Mino-Kenudson M, Holalkere NS, Alsfasser G, Saini S, Lee SI, Mueller PR, Fernandez-del Castillo C, Warshaw AL, Thayer SP. Imaging of acute mesenteric ischemia using multidetector CT and CT angiography in a porcine model. J Gastrointest Surg. 2005;9(9):1262-74; discussion 74-5. Epub 2005/12/08. doi: 10.1016/j.gassur.2005.07.034. PubMed PMID: 16332482; PMCID: PMC3807105.

11. Rodriguez JR, Soto Germes S, Pandharipande PV, Gazelle GS, Thayer SP, Warshaw AL, Fernández-del Castillo C. Implications and cost of pancreatic leak following distal pancreatic resection. Arch Surg 2006; 141(4):361-365; discussion 366. PMID: 16618893; PMCID; PMC3998722.

12. Ferrone CR, Finkelstein D, Thayer SP, Muzikansky A, Fernández-del Castillo C, Warshaw AL. Perioperative CA19-9 levels can predict stage and survival in patients with resectable pancreatic adenocarcinoma. J Clin Oncol 2006; Jun 20;24(18):2897-2902. doi: 10.1200/JCO.2005.05.3934. PMID: 16782929.

13. Alsfasser G, Warshaw AL, Thayer SP, Antoniu B, Laposata M, Lewandrowski KB, Fernández-del Castillo C. Decreased inflammation and improved survival with recombinant human activated protein C treatment in experimental acute pancreatitis. Arch Surg 2006;141(7):670-676; discussion 670-676. doi: 10.1001/archsurg.141.7.670 PMID: 16847238; PMCID: PMC3972126.

14. Kwak EL, Jankowski J, Thayer SP, Lauwers GY, Brannigan BW, Harris PL, Okimoto RA, Haserlat SM, Driscoll DR, Ferry D, Muir B, Settleman J, Fuchs CS, Kulke MH, Ryan DP, Clark JW, Sgroi DC, Haber DA, Bell DW. Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomas. Clin Cancer Res 2006;12(14 Pt 1):4283-4287. doi: 10.1158/1078-0432.CCR-06-0189. PMID: 16857803; PMID: 16857803.

15. Mao J, Ligon KL, Rakhlin EY, Thayer SP, Bronson RT, Rowitch D, McMahon AP. A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res 2006; 66(20):10171-10178. doi: 10.1158/0008-5472.CAN-06-0657. PMID: 17047082; PMCID: PMC3806052.

16. Strobel O, Dor Y, Stirman A, Trainor A, Fernández-del Castillo C, Warshaw AL, Thayer SP. β cell transdifferentiation does not contribute to preneoplastic/metaplastic ductal lesions of the pancreas by genetic lineage tracing in vivo. PNAS 2007; 104:4419-4424. doi: 10.1073/pnas.0605248104 PMID: 1736053; PMCID: PMC1815470.

17. Vagefi PA, Razo O, Deshpande V, McGrath DJ, Lauwers GY, Thayer SP, Warshaw AL, Fernández-del Castillo C. Evolving patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms. Arch Surg 2007; 142:347-354. doi: 10.1001/archsurg.142.4.347. PMID: 17438169; PMCID: PMC3979851.

18. Crippa S, Bassi C, Warshaw AL, Falconi M, Partelli S, Thayer SP, Pederzoli P, Fernández-del Castillo C. Middle pancreatectomy: Indications, short- and long-term operative outcomes. Ann Surg 2007; 246(1):69-76. doi: 10.1097/01.sla.0000262790.51512.57. PMID: 17592293; PMCID: PMC1899210.

19. Rodriguez JR, Salvia R, Crippa S, Warshaw AL, Bassi C, Falconi M, Thayer SP, Lauwers GY, Capelli P, Mino-Kenudson M, McGrath D, Pederzoli P, Fernández-del Castillo C. Branch-duct intraductal papillary mucinous neoplasms: observations in 145 resected


patients. Gastroenterology 2007; 133:72-79. doi: 10.1053/j.gastro.2007.05.010. PMID: 17631133; PMCID: PMC3807096.

20. Rodriguez JR, Madanat MG, Healy BC, Thayer SP, Warshaw AL, Fernández-del Castillo C. Distal pancreatectomy with splenic preservation revisited. Surgery 2007; 141:619-625. doi: 10.1016/j.surg.2006.09.020 PMID: 17462461; PMCID: PMC3807103.

21. Strobel O, Dor Y, Alsina J, Stirman A, Lauwers G, Trainor A, Fernández-del Castillo C, Warshaw AL, Thayer SP. In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia. Gastroenterol 2007; 133:1999-2009. doi: 10.1053/j.gastro.2007.09.009. PMID: 18054571; PMCID: PMC2254582.

22. Nikfarjam M, Warshaw AL, Axelrod L, Deshpande V, Thayer SP, Ferrone CR, Fernández-del Castillo C. Improved contemporary surgical management of insulinomas: a 25-year experience at the Massachusetts General Hospital. Ann Surg 2008; 247(1):165-172. doi: 10.1097/SLA.0b013e31815792ed PMID: 18156937; PMCID: PMC3806046.

23. Rodriguez JR, Razo AO, Targarona J, Thayer SP, Rattner DW, Warshaw AL, Fernandez-del Castillo C. Debridement and closed packing for sterile or infected necrotizing pancreatitis: insights into indications and outcomes in 167 patients. Ann Surg. 2008;247(2):294-9. Epub 2008/01/25. doi: 10.1097/SLA.0b013e31815b6976. PMID: 18216536; PMCID: PMC3806106.

24. Crippa S, Salvia R, Warshaw AL, Dominguez I, Bassi C, Falconi M, Thayer SP, Zamboni G, Lauwers GY, Mino-Kenudson M, Capelli P, Pederzoli P, Castillo CF. Mucinous cystic neoplasm of the pancreas is not an aggressive entity: lessons from 163 resected patients. Ann Surg. 2008;247(4):571-9. doi: 10.1097/SLA.0b013e31811f4449. PMID: 18362619; PMCID: 3806104.

25. Veillette G, Dominguez I, Ferrone C, Thayer SP, McGrath D, Warshaw AL, Fernandez-del Castillo C. Implications and management of pancreatic fistulas following pancreaticoduodenectomy: the Massachusetts General Hospital experience. Arch Surg. 2008;143(5):476-81. Epub 2008/05/21. doi: 10.1001/archsurg.143.5.476. PMID: 18490557; PMCID: PMC3806102.

26. Dominguez I, Crippa S, Thayer SP, Hung YP, Ferrone CR, Warshaw AL, Fernandez-Del Castillo C. Preoperative platelet count and survival prognosis in resected pancreatic ductal adenocarcinoma. World J Surg. 2008;32(6):1051-6. doi: 10.1007/s00268-007-9423-6. PMID: 18224462; PMCID: 3806089.

27. Crippa S, Dominguez I, Rodriguez JR, Razo O, Thayer SP, Ryan DP, Warshaw AL, Fernandez-del Castillo C. Quality of life in pancreatic cancer: analysis by stage and treatment. J Gastrointest Surg. 2008;12(5):783-93; discussion 93-4. doi: 10.1007/s11605-007-0391-9. PMID: 18317851; PMCID: 3806099.

28. Guimaraes AR, Rakhlin E, Weissleder R, Thayer SP. Magnetic resonance imaging monitors physiological changes with antihedgehog therapy in pancreatic adenocarcinoma xenograft model. Pancreas. 2008;37(4):440-4. doi: 10.1097/MPA.0b013e31817c5113. PMID: 18953259; PMCID: 3806135.

29. Ferrone CR, Warshaw AL, Rattner DW, Berger D, Zheng H, Rawal B, Rodriguez R, Thayer SP, Fernandez-del Castillo C. Pancreatic fistula rates after 462 distal pancreatectomies: staplers do not decrease fistula rates. J Gastrointest Surg. 2008;12(10):1691-7; discussion 7-8. doi: 10.1007/s11605-008-0636-2. PMID: 18704597; PMCID: 3806097.

Sarah P. Thayer, M.D., Ph.D. Page 18 30. Fritz S, Fernandez-del Castillo C, Mino-Kenudson M, Crippa S, Deshpande V, Lauwers

GY, Warshaw AL, Thayer SP, Iafrate AJ. Global genomic analysis of intraductal papillary mucinous neoplasms of the pancreas reveals significant molecular differences compared to ductal adenocarcinoma. Ann Surg. 2009;249(3):440-7. doi: 10.1097/SLA.0b013e31819a6e16. PMID: 19247032; PMCID: 3957431.

31. Fritz S, Warshaw AL, Thayer SP. Management of mucin-producing cystic neoplasms of the pancreas. Oncologist. 2009;14(2):125-36. doi: 10.1634/theoncologist.2008-0200. PMID: 19211618; PMCID: 3806054.

32. LaFemina J, Roberts PA, Hung YP, Gusella JF, Sahani D, Fernandez-del Castillo C, Warshaw AL, Thayer SP. Identification of a novel kindred with familial pancreatitis and pancreatic cancer. Pancreatology : official journal of the International Association of Pancreatology. 2009;9(3):273-9. doi: 10.1159/000201553. PMID: 19407482; PMCID: 3713708.

33. Bausch D, Mino-Kenudson M, Fernandez-Del Castillo C, Warshaw AL, Kelly KA, Thayer SP. Plectin-1 is a biomarker of malignant pancreatic intraductal papillary mucinous neoplasms. J Gastrointest Surg. 2009;13(11):1948-54; discussion 54. doi: 10.1007/s11605-009-1001-9. PMID: 19760374; PMCID: 3806105.

34. Ferrone CR, Correa-Gallego C, Warshaw AL, Brugge WR, Forcione DG, Thayer SP, Fernandez-del Castillo C. Current trends in pancreatic cystic neoplasms. Arch Surg. 2009;144(5):448-54. doi: 10.1001/archsurg.2009.36. PMID: 19451487; PMCID: 3806091.

35. Strobel O, Rosow DE, Rakhlin EY, Lauwers GY, Trainor AG, Alsina J, Fernandez-Del Castillo C, Warshaw AL, Thayer SP. Pancreatic duct glands are distinct ductal compartments that react to chronic injury and mediate Shh-induced metaplasia. Gastroenterology. 2010;138(3):1166-77. doi: 10.1053/j.gastro.2009.12.005. PMID: 20026066; PMCID: 3806111.

36. Fritz S, Fernandez-del Castillo C, Iafrate AJ, Mino-Kenudson M, Neyhard N, LaFemina J, Stirman A, Warshaw AL, Thayer SP. Novel xenograft and cell line derived from an invasive intraductal papillary mucinous neoplasm of the pancreas give new insights into molecular mechanisms. Pancreas. 2010;39(3):308-14. doi: 10.1097/MPA.0b013e3181bd5c10. PMID: 19924021; PMCID: 3086384.

37. Rovira M, Scott SG, Liss AS, Jensen J, Thayer SP, Leach SD. Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas. Proc Natl Acad Sci U S A. 2010;107(1):75-80. doi: 10.1073/pnas.0912589107. PMID: 20018761; PMCID: 2806716.

38. Iyer VR, Hahn PF, Blaszkowsky LS, Thayer SP, Halpern EF, Harisinghani MG. Added value of selected images embedded into radiology reports to referring clinicians. Journal of the American College of Radiology : JACR. 2010;7(3):205-10. doi: 10.1016/j.jacr.2009.10.014. PMID: 20193926; PMCID: 3086392.

39. Crippa S, Fernandez-Del Castillo C, Salvia R, Finkelstein D, Bassi C, Dominguez I, Muzikansky A, Thayer SP, Falconi M, Mino-Kenudson M, Capelli P, Lauwers GY, Partelli S, Pederzoli P, Warshaw AL. Mucin-producing neoplasms of the pancreas: an analysis of distinguishing clinical and epidemiologic characteristics. Clin Gastroenterol Hepatol. 2010;8(2):213-9. doi: 10.1016/j.cgh.2009.10.001. PMID: 19835989; PMCID: 3135334.

40. Konstantinidis IT, Deshpande V, Zheng H, Wargo JA, Fernandez-del Castillo C, Thayer SP, Androutsopoulos V, Lauwers GY, Warshaw AL, Ferrone CR. Does the mechanism


of lymph node invasion affect survival in patients with pancreatic ductal adenocarcinoma? J Gastrointest Surg. 2010;14(2):261-7. doi: 10.1007/s11605-009-1096-z. PMID: 19937477; PMCID: 3135335.

41. Partelli S, Fernandez-Del Castillo C, Bassi C, Mantovani W, Thayer SP, Crippa S, Ferrone CR, Falconi M, Pederzoli P, Warshaw AL, Salvia R. Invasive intraductal papillary mucinous carcinomas of the pancreas: predictors of survival and the role of lymph node ratio. Ann Surg. 2010;251(3):477-82. doi: 10.1097/SLA.0b013e3181cf9155. PMID: 20142730; PMCID: 3135381.

42. International Cancer Genome Consortium (collective authorship, Hudson TJ et al., including Thayer SP). International network of cancer genome projects. Nature. 2010;464(7291):993-8. doi: 10.1038/nature08987. PMID: 20393554; PMCID: 2902243.

43. Correa-Gallego C, Ferrone CR, Thayer SP, Wargo JA, Warshaw AL, Fernandez-Del Castillo C. Incidental pancreatic cysts: do we really know what we are watching? Pancreatology : official journal of the International Association of Pancreatology. 2010;10(2-3):144-50. doi: 10.1159/000243733. PMID: 20484954; PMCID: 3214832.

44. Tempero MA, Arnoletti JP, Behrman S, Ben-Josef E, Benson AB, 3rd, Berlin JD, Cameron JL, Casper ES, Cohen SJ, Duff M, Ellenhorn JD, Hawkins WG, Hoffman JP, Kuvshinoff BW, 2nd, Malafa MP, Muscarella P, 2nd, Nakakura EK, Sasson AR, Thayer SP, Tyler DS, Warren RS, Whiting S, Willett C, Wolff RA, Adenocarcinoma NP. Pancreatic adenocarcinoma. J Natl Compr Canc Netw. 2010;8(9):972-1017. PMID: 20876541; PMCID: 3135380.

45. Konstantinidis IT, Dursun A, Zheng H, Wargo JA, Thayer SP, Fernandez-del Castillo C, Warshaw AL, Ferrone CR. Metastatic tumors in the pancreas in the modern era. J Am Coll Surg. 2010;211(6):749-53. doi: 10.1016/j.jamcollsurg.2010.08.017. PMID: 21109158; PMCID: 3135384.

46. Bausch D, Thomas S, Mino-Kenudson M, Fernández-del Castillo C, Bauer TW, Williams M, Warshaw AL, Thayer SP, Kelly KA. Plectin-1 as a novel biomarker for pancreatic cancer. Clin Cancer Res 2011 Jan 15; 17(2):302-309. Epub 2010 Nov 23. doi: 10.1158/1078-0432.CCR-10-0999. PMID: 21098698; PMCID: PMC3044444.

47. Bausch D, Pausch T, Krauss T, Hopt UT, Fernandez-del-Castillo C, Warshaw AL, Thayer SP, Keck T. Neutrophil granulocyte derived MMP-9 is a VEGF independent functional component of the angiogenic switch in pancreatic ductal adenocarcinoma. Angiogenesis. 2011;14(3):235-43. doi: 10.1007/s10456-011-9207-3. PMID: 21442180; PMCID: 3688040.

48. Haynes AB, Deshpande V, Ingkakul T, Vagefi PA, Szymonifka J, Thayer SP, Ferrone CR, Wargo JA, Warshaw AL, Fernandez-del Castillo C. Implications of incidentally discovered, nonfunctioning pancreatic endocrine tumors: short-term and long-term patient outcomes. Arch Surg. 2011;146(5):534-8. doi: 10.1001/archsurg.2011.102. PMID: 21576607; PMCID: 3688044.

49. Mino-Kenudson M, Fernandez-del Castillo C, Baba Y, Valsangkar NP, Liss AS, Hsu M, Correa-Gallego C, Ingkakul T, Perez Johnston R, Turner BG, Androutsopoulos V, Deshpande V, McGrath D, Sahani DV, Brugge WR, Ogino S, Pitman MB, Warshaw AL, Thayer SP. Prognosis of invasive intraductal papillary mucinous neoplasm depends on histological and precursor epithelial subtypes. Gut. 2011;60(12):1712-20. doi: 10.1136/gut.2010.232272. PMID: 21508421; PMCID: 3806085.

50. Genevay M, Mino-Kenudson M, Yaeger K, Konstantinidis IT, Ferrone CR, Thayer S, Castillo CF, Sahani D, Bounds B, Forcione D, Brugge WR, Pitman MB. Cytology adds


value to imaging studies for risk assessment of malignancy in pancreatic mucinous cysts. Ann Surg. 2011;254(6):977-83. doi: 10.1097/SLA.0b013e3182383118. PMID: 22041510; PMCID: 3817564.

51. Ying H, Elpek KG, Vinjamoori A, Zimmerman SM, Chu GC, Yan H, Fletcher-Sananikone E, Zhang H, Liu Y, Wang W, Ren X, Zheng H, Kimmelman AC, Paik JH, Lim C, Perry SR, Jiang S, Malinn B, Protopopov A, Colla S, Xiao Y, Hezel AF, Bardeesy N, Turley SJ, Wang YA, Chin L, Thayer SP, DePinho RA. PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-kappaB-cytokine network. Cancer Discov. 2011;1(2):158-69. doi: 10.1158/2159-8290.CD-11-0031. PMID: 21984975; PMCID: 3186945.

52. Tempero MA, Arnoletti JP, Behrman SW, Ben-Josef E, Benson AB, 3rd, Casper ES, Cohen SJ, Czito B, Ellenhorn JD, Hawkins WG, Herman J, Hoffman JP, Ko A, Komanduri S, Koong A, Ma WW, Malafa MP, Merchant NB, Mulvihill SJ, Muscarella P, 2nd, Nakakura EK, Obando J, Pitman MB, Sasson AR, Tally A, Thayer SP, Whiting S, Wolff RA, Wolpin BM, Freedman-Cass DA, Shead DA, National Comprehensive Cancer N. Pancreatic Adenocarcinoma, version 2.2012: featured updates to the NCCN Guidelines. J Natl Compr Canc Netw. 2012;10(6):703-13. PMID: 22679115; PMCID: 3807091.

53. Scherber C, Aranyosi AJ, Kulemann B, Thayer SP, Toner M, Iliopoulos O, Irimia D. Epithelial cell guidance by self-generated EGF gradients. Integr Biol (Camb). 2012;4(3):259-69. doi: 10.1039/c2ib00106c. PMID: 22314635; PMCID: 3440622.

54. Nehra D, Oyarvide VM, Mino-Kenudson M, Thayer SP, Ferrone CR, Wargo JA, Muzikansky A, Finkelstein D, Warshaw AL, Castillo CF. Intraductal papillary mucinous neoplasms: does a family history of pancreatic cancer matter? Pancreatology : official journal of the International Association of Pancreatology. 2012;12(4):358-63. doi: 10.1016/j.pan.2012.05.011. PMID: 22898638; PMCID: 3806100.

55. Valsangkar NP, Morales-Oyarvide V, Thayer SP, Ferrone CR, Wargo JA, Warshaw AL, Fernandez-del Castillo C. 851 resected cystic tumors of the pancreas: a 33-year experience at the Massachusetts General Hospital. Surgery. 2012;152(3 Suppl 1):S4-12. doi: 10.1016/j.surg.2012.05.033. PMID: 22770958; PMCID: 3806101.

56. Cogdill AP, Frederick DT, Cooper ZA, Garber HR, Ferrone CR, Fiedler A, Rosenberg L, Thayer SP, Warshaw AL, Wargo JA. Targeting the MAGE A3 antigen in pancreatic cancer. Surgery. 2012;152(3 Suppl 1):S13-8. doi: 10.1016/j.surg.2012.05.031. PMID: 22770803; PMCID: 3806055.

57. Ferrone CR, Pieretti-Vanmarcke R, Bloom JP, Zheng H, Szymonifka J, Wargo JA, Thayer SP, Lauwers GY, Deshpande V, Mino-Kenudson M, Fernandez-del Castillo C, Lillemoe KD, Warshaw AL. Pancreatic ductal adenocarcinoma: long-term survival does not equal cure. Surgery. 2012;152(3 Suppl 1):S43-9. doi: 10.1016/j.surg.2012.05.020. PMID: 22763261; PMCID: 3806092.

58. Fernandez-del Castillo C, Morales-Oyarvide V, McGrath D, Wargo JA, Ferrone CR, Thayer SP, Lillemoe KD, Warshaw AL. Evolution of the Whipple procedure at the Massachusetts General Hospital. Surgery. 2012;152(3 Suppl 1):S56-63. doi: 10.1016/j.surg.2012.05.022. PMID: 22770961; PMCID: 3806095.

59. Rosow DE, Liss AS, Strobel O, Fritz S, Bausch D, Valsangkar NP, Alsina J, Kulemann B, Park JK, Yamaguchi J, LaFemina J, Thayer SP. Sonic Hedgehog in pancreatic cancer: from bench to bedside, then back to the bench. Surgery. 2012;152(3 Suppl 1):S19-32. doi: 10.1016/j.surg.2012.05.030. PMID: 22770959; PMCID: 3806061.

Sarah P. Thayer, M.D., Ph.D. Page 21 60. Valsangkar NP, Bush DM, Michaelson JS, Ferrone CR, Wargo JA, Lillemoe KD,

Fernandez-del Castillo C, Warshaw AL, Thayer SP. N0/N1, PNL, or LNR? The effect of lymph node number on accurate survival prediction in pancreatic ductal adenocarcinoma. J Gastrointest Surg. 2013;17(2):257-66. doi: 10.1007/s11605-012-1974-7. PMID: 23229885; PMCID: 3806050.

61. Faris JE, Blaszkowsky LS, McDermott S, Guimaraes AR, Szymonifka J, Huynh MA, Ferrone CR, Wargo JA, Allen JN, Dias LE, Kwak EL, Lillemoe KD, Thayer SP, Murphy JE, Zhu AX, Sahani DV, Wo JY, Clark JW, Fernandez-del Castillo C, Ryan DP, Hong TS. FOLFIRINOX in locally advanced pancreatic cancer: the Massachusetts General Hospital Cancer Center experience. Oncologist. 2013;18(5):543-8. doi: 10.1634/theoncologist.2012-0435. PMID: 23657686; PMCID: 3662845.

62. Sahora K, Mino-Kenudson M, Brugge W, Thayer SP, Ferrone CR, Sahani D, Pitman MB, Warshaw AL, Lillemoe KD, Fernandez-del Castillo CF. Branch duct intraductal papillary mucinous neoplasms: does cyst size change the tip of the scale? A critical analysis of the revised international consensus guidelines in a large single-institutional series. Ann Surg. 2013;258(3):466-75. doi: 10.1097/SLA.0b013e3182a18f48. PMID: 24022439.

63. Cai S, Hong TS, Goldberg SI, Fernandez-del Castillo C, Thayer SP, Ferrone CR, Ryan DP, Blaszkowsky LS, Kwak EL, Willett CG, Lillemoe KD, Warshaw AL, Wo JY. Updated long-term outcomes and prognostic factors for patients with unresectable locally advanced pancreatic cancer treated with intraoperative radiotherapy at the Massachusetts General Hospital, 1978 to 2010. Cancer. 2013;119(23):4196-204. doi: 10.1002/cncr.28329. PMID: 24006012.

64. Fong ZV, Ferrone CR, Thayer SP, Wargo JA, Sahora K, Seefeld KJ, Warshaw AL, Lillemoe KD, Hutter MM, Fernandez-Del Castillo C. Understanding hospital readmissions after pancreaticoduodenectomy: can we prevent them?: a 10-year contemporary experience with 1,173 patients at the Massachusetts General Hospital. J Gastrointest Surg. 2014;18(1):137-44; discussion 44-5. doi: 10.1007/s11605-013-2336-9. PMID: 24002770.

65. Fernandez-del Castillo CF, Thayer SP, Ferrone CR, Wargo J. Surgery for small and asymptomatic branch-duct IPMNs. Ann Surg. 2014;259(3):e47. doi: 10.1097/SLA.0000000000000270. PMID: 24096750.

66. McDermott S, Thayer SP, Fernandez-Del Castillo C, Mino-Kenudson M, Weissleder R, Harisinghani MG. Accurate prediction of nodal status in preoperative patients with pancreatic ductal adenocarcinoma using next-gen nanoparticle. Transl Oncol. 2013;6(6):670-5. PMID: 24466369; PMCID: 3890701.

67. Hedgire SS, Mino-Kenudson M, Elmi A, Thayer S, Fernandez-del Castillo C, Harisinghani MG. Enhanced primary tumor delineation in pancreatic adenocarcinoma using ultrasmall super paramagnetic iron oxide nanoparticle-ferumoxytol: an initial experience with histopathologic correlation. Int J Nanomed. 2014;9:1891-6. doi: 10.2147/IJN.S59788. PMID: 24790431; PMCID: 4000182.

68. Lee GC, Fong ZV, Ferrone CR, Thayer SP, Warshaw AL, Lillemoe KD, Fernandez-Del Castillo C. High Performing Whipple Patients: Factors Associated with Short Length of Stay after Open Pancreaticoduodenectomy. J Gastrointest Surg. 2014. doi: 10.1007/s11605-014-2604-3. PMID: 25091843.

Sarah P. Thayer, M.D., Ph.D. Page 22 69. Marchegiani G, Mino-Kenudson M, Sahora K, Morales-Oyarvide V, Thayer S, Ferrone

C, Warshaw AL, Lillemoe KD, Fernandez-Del Castillo C. IPMN Involving the Main Pancreatic Duct: Biology, Epidemiology, and Long-Term Outcomes Following Resection. Ann Surg. 2014. doi: 10.1097/SLA.0000000000000813. PMID: 24979607.

70. Sahora K, Morales-Oyarvide V, Thayer SP, Ferrone CR, Warshaw AL, Lillemoe KD, Fernandez-Del Castillo C. The effect of antecolic versus retrocolic reconstruction on delayed gastric emptying after classic non-pylorus-preserving pancreaticoduodenectomy. Am J Surg. 2014. doi: 10.1016/j.amjsurg.2014.04.015. PMID: 25124295.

71. Sahora K, Castillo CF, Dong F, Marchegiani G, Thayer SP, Ferrone CR, Sahani DV, Brugge WR, Warshaw AL, Lillemoe KD, Mino-Kenudson M. Not all mixed-type intraductal papillary mucinous neoplasms behave like main-duct lesions: Implications of minimal involvement of the main pancreatic duct. Surgery. 2014;156(3):611-21. doi: 10.1016/j.surg.2014.04.023. PMID: 25081232.

72. Tempero MA, Malafa MP, Behrman SW, Benson AB, 3rd, Casper ES, Chiorean EG, Chung V, Cohen SJ, Czito B, Engebretson A, Feng M, Hawkins WG, Herman J, Hoffman JP, Ko A, Komanduri S, Koong A, Lowy AM, Ma WW, Merchant NB, Mulvihill SJ, Muscarella P, 2nd, Nakakura EK, Obando J, Pitman MB, Reddy S, Sasson AR, Thayer SP, Weekes CD, Wolff RA, Wolpin BM, Burns JL, Freedman-Cass DA. Pancreatic adenocarcinoma, version 2.2014: featured updates to the NCCN guidelines. J Natl Compr Canc Netw. 2014;12(8):1083-93. PMID: 25099441.

73. Naraghi L, Peev MP, Esteve R, Chang Y, Berger DL, Thayer SP, Rattner DW, Lillemoe KD, Kaafarani H, Yeh DD, de Moya MA, Fagenholz PJ, Velmahos GS, King DR. The influence of anesthesia on heart rate complexity during elective and urgent surgery in 128 patients. J Crit Care. 2015;30(1):145-9. doi: 10.1016/j.jcrc.2014.08.008. PMID: 25239820.

74. Valsangkar NP, Ingkakul T, Correa-Gallego C, Mino-Kenudson M, Masia R, Lillemoe KD, Castillo CF, Warshaw AL, Liss AS, Thayer SP. Survival in ampullary cancer: Potential role of different KRAS mutations. Surgery. 2015;157(2):260-8. doi: 10.1016/j.surg.2014.08.092. PMID: 25616942.

75. Kulemann B, Pitman MB, Liss AS, Valsangkar N, Fernandez-Del Castillo C, Lillemoe KD, Hoeppner J, Mino-Kenudson M, Warshaw AL, Thayer SP. Circulating tumor cells found in patients with localized and advanced pancreatic cancer. Pancreas. 2015;44(4):547-50. doi: 10.1097/MPA.0000000000000324. PMID: 25822154.

77. Herman JM, Hoffman JP, Thayer SP, Wolff RA. Management of the Primary Tumor and Limited Metastases in Patients With Metastatic Pancreatic Cancer. J Natl Compr Canc Netw. 2015;13(5):e29-36. Epub 2015/07/15. PMID: 26158133.

78. Yamaguchi J, Liss AS, Sontheimer A, Mino-Kenudson M, Castillo CF, Warshaw AL, Thayer SP. Pancreatic duct glands (PDGs) are a progenitor compartment responsible for pancreatic ductal epithelial repair. Stem cell research. 2015;15(1):190-202. Epub 2015/06/24. doi: 10.1016/j.scr.2015.05.006. PMID: 26100232.

79. Chari ST, Kelly K, Hollingsworth MA, Thayer SP, Ahlquist DA, Andersen DK, Batra SK, Brentnall TA, Canto M, Cleeter DF, Firpo MA, Gambhir SS, Go VL, Hines OJ, Kenner BJ, Klimstra DS, Lerch MM, Levy MJ, Maitra A, Mulvihill SJ, Petersen GM, Rhim AD, Simeone DM, Srivastava S, Tanaka M, Vinik AI, Wong D. Early detection of sporadic pancreatic cancer: summative review. Pancreas. 2015;44(5):693-712. Epub 2015/05/02. doi: 10.1097/mpa.0000000000000368. PMID: 25931254; PMCID: PMC4467589.

Sarah P. Thayer, M.D., Ph.D. Page 23 80. Cauley CE, Pitman MB, Zhou J, Perkins J, Kuleman B, Liss AS, Fernandez-Del Castillo C,

Warshaw AL, Lillemoe KD, Thayer SP. Circulating Epithelial Cells in Patients with Pancreatic Lesions: Clinical and Pathologic Findings. J Am Coll Surg. 2015;221(3):699-707. Epub 2015/07/26. doi: 10.1016/j.jamcollsurg.2015.05.014. PMID: 26209458; PMCID: Pmc4546900.

81. Huang Y, Nahar S, Nakagawa A, Fernandez-Barrena MG, Mertz JA, Bryant BM, Adams CE, Mino-Kenudson M, Von Alt KN, Chang K, Conery AR, Hatton C, Sims RJ, 3rd, Fernandez-Zapico ME, Wang X, Lillemoe KD, Fernandez-Del Castillo C, Warshaw AL, Thayer SP, Liss AS. Regulation of GLI Underlies a Role for BET Bromodomains in Pancreatic Cancer Growth and the Tumor Microenvironment. Clin Cancer Res. 2016 May 11. Epub ahead of print. doi: 10.1158/1078-0432.CCR-15-2068. PMID: 27169995.

82. Sahora K, Morales-Oyarvide V, Thayer SP, Ferrone CR, Warshaw AL, Lillemoe KD, Fernandez-Del Castillo C. The effect of antecolic versus retrocolic reconstruction on delayed gastric emptying after classic non-pylorus-preserving pancreaticoduodenectomy. Am J Surg. 2014. doi: 10.1016/j.amjsurg.2014.04.015. PMID: 25124295.

83. Yamaguchi J, Mino-Kenudson M, Liss AS, Chowdhury S, Wang, TC, Fernandez-del Castillo C, Lillemoe, KD, Warshaw AL, Thayer SP. Loss of trefoil factor 2 from pancreatic duct glands accelerates formation of intraductal papillary mucinous neoplasms. Gastroenterology. 2016. Dec;151(6):1232-1244.e10. doi: 10.1053/j.gastro.2016.07.045. PubMed PMID: 27523981. Epub 2016 Aug 12.

84. Conner A, Denroche R, Jang GH, Timms L, Kalimuthu S, Selander I, McPherson T, Wilson G, Chan-Seng-Yue M, Borozan I, Ferretti V, Grant R, Lungu I, Costello-Goldring E, Greenhalf W, Palmer D, Ghaneh P, Neoptolemos J, Buchler M, Petersen G, Thayer S, Hollingsworth M, Sherker A, Durocher D, Dhani N, Hedley D, Serra S, Pollett A, Roehrl M, Bavi P, Bartlett J, Cleary S, Wilson J, Alexandrov L, Moore M, Wouters B, McPherson J, Notta Faiyaz, Stein L, Gallinger S. Distinct mutational signatures are associated with correlates of increased immune activity in pancreatic ductal adenocarcinoma. JAMA Oncology. 2016 Oct 20. doi: 10.1001/jamaoncol.2016.3916. [Epub ahead of print]

85. Saung MT, Sharei A, Adalsteinsson VA, Cho N, Kamath T, Ruiz C, Kirkpatrick J, Petal N, Mino-Kenudson M, Thayer SP, Langer R, Jensen KF, Liss AS, Love JC. A size-selective intracellular delivery platform. Small. 2016. Sep 4. doi: 10.1002/smll.201601155. [Epub ahead of print].

86. Rosembaum M; Cauley C; Kulemann B; Liss A; Fernandez C; Warshaw A; Lillemoe K; Thayer S; Pitman M. Cytologic Characteristics of Circulating Epithelioid Cells in Pancreatic Disease. Accepted Cancer Cytopathology, January 26, 2017.

Submitted: 1. Geller LT; Barzily-Rokni M; Danino T; Jonas OH; Shental N; Nejman D; Cooper ZA;

Shee K; Thaiss CA; Reuben A; Livny J; Avraham R; Frederick DT; Ligorio M; Chatman K; Johnston SE; Mosher CM; Smith DA; Skalak M; Bu J; Michaud M; Traugher SA; Flaherty KT; Mandinova A; Garrett WS; Thayer SP; Ferrone CR; Huttenhower C; Bhatia SN; Gevers D; Wargo JA; Golub TR; Straussman R. Intra-tumor bacteria elicit drug resistance in pancreatic ductal adenocarcinoma. Submitted to Science 06/2016

Sarah P. Thayer, M.D., Ph.D. Page 24 Reviews, Chapters, and Editorials:

1. Thayer SP, Warshaw AL. “Periampullary Cancer” (chapter). 8th Edition, Current Surgical Therapy (John L. Cameron, Editor). Philadelphia: Elsevier Mosby, 2004, pp. 494-504.

2. Alsfasser G, Warshaw AL, Thayer SP, Antoniu B, Laposata M, Lewandrowski K, Klar E, Fernández-del Castillo C. “Aktiviertes Protein C hemmt die Entzündungsreaktion und verbessert das Überleben bei experimenteller akuter Pankreatitis“ [Activated Protein C decreases inflammation and improves survival in experimental acute pancreatitis]. Chirurgisches Forum 2005 (M. Rothmund, K.-W. Jauch and H. Bauer, Editors). Berlin/Heidelberg, Springer, 2005, pp. 235-236.

3. Thayer SP. “Commentary on: Lin JW, Leach SD. Pancreatic development.” Chapter 5 in Pancreatic Cancer (R. H. Ruban et al., Editors). Sudbury, MA: Jones and Bartlett Publishers, 2005, pp. 84-86.

4. Boland GM, Thayer SP. “Molecular signaling pathways in pancreatic cancer.” Chapter 11 in Pancreatic Cancer (Andrew Lowy, Steven Leach, and Philip Philip, Editors). New York: Springer, 2008, pp. 181-228.

5. Alsina J, Thayer SP. “Hereditary pancreatic cancer.” Chapter in MGH Guide to Clinical Cancer Genetics (Daniel Chung, Editor). New York: Springer, 2010, pp. 89-96.

6. Liss AS, Thayer SP. Therapeutic targeting of pancreatic stroma. Chapter 9 in: Pancreatic Cancer and the Tumor Microenvironment: Mesenchyme’s Role in Pancreatic Carcinogenesis (Paul J. Grippo and Hidayatullah G. Munshi, Editors). Trivandrum (India): Transworld Research Network, 2012. PMID: 22876383.

7. Thayer SP, Nakul V. Acute Pancreatitis. Chapter 11 in Current Surgical Therapy, 11th Edition (Andrew Cameron, Editor). New York: Elsevier, 2013, pp. 431-39.

Doctoral Dissertation:

1. Thayer SP. “Transcriptional activation of the MDR1 gene in retinoic acid stimulated neuroblastoma cells involves derepression and activation by multiple Sp family members.“ Ithaca, NY: Cornell University, 1999.

Abstracts and Presentations: 1. Lee V, Chen J, Dubois M, Thayer SP, McNamara S. Continuous muscle relaxant infusion

with EMG monitoring. Annual Meeting, Southern Medical Association, Atlanta, GA, 1986.

2. Thayer SP. “An upstream binding element is required for retinoic acid-stimulated transcription of the MDR1 promoter in human neuroblastoma cells.” Presentation, Annual Meeting, AACR, San Diego, CA, April 12-16, 1997.

3. Friedman D, Thayer SP, Scotto KW. “Activation of MDR1 gene in retinoic acid-stimulated neuroblastoma cells involves derepression and activation by multiple Sp family members.“ Presentation, Annual Meeting, AACR, Philadelphia, PA, April 10-14, 1999.

4. Balcom JH, Keck T, Warshaw AL, Thayer SP, Antoniu B, Graeme-Cook F, Fernandez-del-Castillo C. “Prevention of clinically significant pancreatic fistulae with a new, absorbable hydrogel sealant after distal pancreatectomy in the dog.” Poster, Annual Meeting SSAT, Atlanta, GA, May 21, 2001.

Sarah P. Thayer, M.D., Ph.D. Page 25 5. Fernández-del Castillo C, Targarona J, Thayer SP, Brugge WR, Warshaw AL.

“Incidental pancreatic cysts: Clinicopathological characteristics and comparison to symptomatic patients.” 2002 Annual Meeting, New England Surgical Society, Dixville, NH, September 27-29, 2002.

6. Thayer SP, Roberts D, Nielsen C, Fernández-del Castillo C, Warshaw AL. “The developmental signaling factor Sonic Hedgehog is abnormally expressed in neoplastic pancreata and drives an intestinal metaplasia of the adult human pancreas.” Poster, Annual Meeting APA, Chicago, IL, November 14-15, 2002.

7. Stein SL, Warshaw AL, Fernández-del Castillo C, Lauwers GY, Sahani D, Thayer SP. Autoimmune pancreatitis masquerading as pancreatic cancer: A diagnostic dilemma. 84th Annual Meeting, New England Surgical Society, September 19-23, 2003, Newport, RI.

8. Thayer SP, Roberts D, Nielsen C, Fernández-del Castillo C, Warshaw AL. “To characterize the contribution of Sonic hedgehog to pancreatic neoplasia.” Scientific Advisory Committee Symposium MGH, Boston, MA, February 5, 2003.

9. Salvia R, Fernández-del Castillo C, Bassi C, Thayer S, Falconi M, Pederzoli P, Warshaw AL. “Can malignancy be predicted in main duct intraductal papillary mucinous tumors of the pancreas (IPMNs)?” Pancreas Club, Orlando, FL, May 18, 2003.

10. Alsfasser G, Targarona J, Thayer SP, Warshaw AL, Fernández-del Castillo C. “Is serum CA-19-9 useful in the evaluation of patients with cystic lesions of the pancreas?” Poster, Annual Meeting APA, Chicago, IL, November 6-7, 2003.

11. Thayer SP, Roberts DJ, Nielsen CM, Lauwers GY, Fernández-del Castillo C, Antoniu B, Yajnik V, Alsfasser G, Warshaw AL. “Hedgehog, an early mediator of pancreatic cancer tumorigenesis, links altered developmental programs to pancreatic neoplasia.” Presentation, Annual Meeting APA, Chicago, IL, November 6-7, 2003 (Hirshberg Award for Best Presentation).

12. Rosow DE, Balcom JH, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Chemically induced pancreatic ductal adenocarcinomas in mice express Sonic hedgehog.” Poster, 94th Annual Meeting, Molecular Targets and Cancer Therapeutics, AACR, Boston, MA, November 17-21, 2003.

13. Salvia R, Fernández-del Castillo C, Bassi C, Thayer SP, Falconi M, Pederzoli P, Warshaw AL. “Main duct intraductal papillary mucinous neoplasms (IPMNs) of the pancreas: Clinical predictors of malignancy and long-term survival following resection.” Presentation, Annual Meeting, Southern Surgical Association, Hot Springs, VA, December 1-3, 2003.

14. Rosow DE, Balcom JH, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Chemically induced pancreatic ductal adenocarcinomas in mice misexpress the Sonic hedgehog pathway.” Poster, Scientific Advisory Committee Symposium, February 5, 2004, MGH, Boston, MA.

15. Rosow DE, Balcom JH, Trainor AG, Strobel O, Antoniu B, Li L, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Sonic hedgehog is abnormally expressed in dimethylbenzanthracene (DMBA)-induced pancreatic neoplasia and drives a gastrointestinal metaplasia of the adult mouse pancreas.” Poster, 95th Annual Meeting AACR, Orlando, FL, March 27-31, 2004.

15. Strobel O, Trainor A, Li L, Antoniu B, Rosow DE, Fernández-del Castillo C, Warshaw AL, Thayer SP. Sonic hedgehog is misexpressed in the epithelium of branches of the


pancreatic main duct in response to inflammation: Role in pancreatic carcinogenesis. Poster, 95th Annual Meeting AACR, Orlando, FL, March 27-31, 2004.

16. Thayer SP, Roberts DJ, Nielsen CM, Lauwers GY, Strobel O, Rosow DE, Fernández-del Castillo C, Warshaw AL. “The Hedgehog pathway: an initiator and maintenance factor for pancreatic cancer.” Poster, Lustgarten Foundation for Pancreatic Cancer Research/AACR Meeting “Pancreatic Cancer 2004: Advances and Challenges,” San Francisco, CA, June 25-26, 2004.

17. Rosow D, Balcom JH, Trainor AG, Strobel O, Antoniu B, Li L, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Implantation of dimethylbenzanthracene in mice induces pancreatic ductal adenocarcinomas that misexpress the sonic hedgehog pathway.” Poster, Joint Meeting, 11th Meeting of the International Association of Pancreatology and 35th Annual Meeting of the Japan Pancreas Society, Sendai, Japan, July 11-14, 2004. Published in Journal of the Japan Pancreas Society 19(3):285 (2004).

18. Strobel O, Trainor A, Li L, Antoniu B, Rosow DE, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Sonic hedgehog is upregulated in response to inflammation in the epithelium of main duct branches: role in pancreatic carcinogenesis.” Poster, Joint Meeting, 11th Meeting of the International Association of Pancreatology and 35th Annual Meeting of the Japan Pancreas Society, Sendai, Japan, July 11-14, 2004. Published in Journal of the Japan Pancreas Society 19(3):241-242 (2004).

19. Thayer SP, Dor Y, Melton D, Strobel O, Rosow DE, Fernández-del Castillo C, Trainor A, Li L, Warshaw AL. “Carcinogen-induced tubular formations are not of islet cell origin.” Presentation, Joint Meeting, 11th Meeting of the IAP and 35th Annual Meeting of the Japan Pancreas Society, Sendai, Japan, July 11-14, 2004. Published in Journal of the Japan Pancreas Society 19(3):241 (2004).

20. Alsfasser G, Warshaw AL, Thayer SP, Laposata M, Lewandrowski KB, Fernández-del Castillo C. “Activated protein C decreases inflammation and improves survival in experimental acute pancreatitis.” Presentation, Joint Meeting, 11th Meeting of the International Association of Pancreatology and 35th Annual Meeting of the Japan Pancreas Society, Sendai, Japan, July 11-14, 2004.

21. Rosow DE, Strobel O, Trainor AG, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Hedgehog and its pathway members are misexpressed and active in the majority of sporadic human pancreatic adenocarcinomas: A biologically important pathway and potential therapeutic target.” Presentation, Annual Meeting, APA, Chicago, IL, November 4-5, 2004. Published in Pancreas 29(4):338, November 2004.

22. Strobel O, Rosow DE, Trainor AG, Lauwers AG, Li L, Antoniu B, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Duct glands of the pancreatic head up-regulate Shh, GI mucins and rate of proliferation in response to chronic injury and inflammation: Possible origin of pancreatic cancer?” Poster, Annual Meeting, APA, Chicago, IL, November 4-5, 2004. Published in Pancreas 29(4):338-339 (2004).

23. Strobel O, Rosow DE, Trainor AG, Lauwers GY, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Duct glands of the pancreatic head upregulate sonic hedgehog and GI-specific mucins in response to chronic injury: stem cells of pancreatic cancer?” Poster, 96th Annual Meeting, AACR, Anaheim, CA, April 16-20, 2005.

24. Ferrone CP, Thayer SP, Finkelstein DM, Muzikansky A, Mino-Kenudson M, Lauwers G, Warshaw AL. “A decrease in preoperative to postoperative CA19-9 level is a significant predictor of survival in patients with pancreatic adenocarcinoma.” Poster and


Presentation (Merit Award winner), Annual Meeting, ASCO, Orlando, FL, May 13-17, 2005. Published in J Clin Oncol 2005 ASCO Annual Meeting Proceedings 23:4034.

25. Strobel O, Rosow DE, Trainor AG, Lauwers GY, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Duct glands of the pancreatic head upregulate sonic hedgehog as well as gastric and intestinal mucins in response to chronic inflammation: Gastrointestinal metaplasia an early event in pancreatic carcinogenesis.” Poster presentation, American Gastroenterological Association, DDW, Chicago, IL, May 14-19, 2005.

26. Rosow DE, Sahani DV, Strobel O, Alsfasser G, Mino-Kenudson M, Kalva S, Saini S, Lee SI, Wittenberg J, Mueller PR, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Imaging of acute mesenteric ischemia using 16-multi-detector row CT and CT angiography in a porcine model: description of disease evolution with surgical correlation.” Presentation, Presidential Plenary Session, SSAT, DDW, Chicago, IL, May 14-19, 2005 (published in J Gastrointest Surg).

27. Thayer SP, Dor Y, Melton D, Strobel O, Mino-Kenudson M, Lauwers G, Rosow DE, Fernández-del Castillo C, Warshaw AL. “Carcinogen-induced tubular formations are not of acinar cell origin.” Presentation, Pancreas Club, DDW, Chicago, IL, May 14-19, 2005.

28. Strobel O, Lauwers GY, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Differential expression of the developmental factors Sonic Hedgehog and Pdx-1 appears to determine the phenotype of pancreatic ductal epithelium in response to chronic injury.” Poster and Presentation, Pancreas Cancer 2005: State-of-the-Art, Lustgarten Foundation for Pancreatic Cancer Research/Memorial Sloan-Kettering Cancer Center, New York, NY, June 23-24, 2005.

29. Rodriguez R, Soto Germes S, Pandharipande PV, Gazelle GS, Thayer SP, Warshaw AL, Fernández-del Castillo C. “Implications and cost of pancreatic leak following distal pancreatic resection.” 12th Annual Surgical Resident and Fellow Research Presentation Day, New England Surgical Society, Boston, MA, May 27, 2005; awarded First Place for Best Clinical Presentation and presented at the Society's 86th Annual Meeting, Bretton Woods, NH, September 30, 2005.

30. Long DD, Munn LL, Mino-Kenudson M, Antoniu B, Strobel O, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Sonic hedgehog (Shh): A potent angiogenic factor necessary for tumor growth?” Presentation, Annual Meeting, APA, Chicago, IL, November 3-4, 2005.

31. Stirman A, Strobel O, Mikhaylova E, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Generation of a mouse model, Pdx-Shh, which develops precursor lesions of pancreatic cancer (PanINs) from normal ducts.” Poster, Annual Meeting, APA, Chicago, IL, November 3-4, 2005.

32. Strobel O, Dor Y, Stirman A, Mikhaylova E, Trainor A, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Tubular complexes are not of β-cell origin: genetic lineage tracing in a mouse model of pancreatitis.” Poster, Annual Meeting, APA, Chicago, IL, November 3-4, 2005.

33. Strobel O, Lauwers GY, Fernández-del Castillo C, Warshaw AL, Thayer SP. “PanIN 1A or duct glands of the pancreas?” Anatomic proof and characterization of a specialized compartment of the ductal system. Poster, Annual Meeting, APA, Chicago, IL, November 3-4, 2005. Published in Pancreas 31(4):471-472 (2005).

Sarah P. Thayer, M.D., Ph.D. Page 28 34. Rakhlin EY, Rosow DE, Mino-Kenudson M, Stirman AM, Mikhaylova EA, Long D,

Fernández-del Castillo C, Warshaw AL, Thayer SP. “Differentiation status may predict response to Hedgehog pathway inhibition in pancreatic adenocarcinoma.” Poster, Annual Meeting, APA, Chicago, IL, November 3-4, 2005. Published in Pancreas 31(4):464 (2005).

35. Rakhlin EY, Mino-Kenudson M, Warshaw AL, Thayer SP. “Characterization of Sonic hedgehog expression and Hedgehog pathway activity in Barrett's esophagus and esophageal adenocarcinoma.” Poster, 97th Annual Meeting, AACR, Washington, DC, April 1-5, 2006.

36. Hung YP, Thayer SP. “Familial pancreatic disease study.” Presentation, Soma Weiss Day, Harvard Medical School, Boston, MA, September 2006.

37. Vagefi PA, Razo O, Deshpande V, McGrath DJ, Lauwers GY, Thayer SP, Warshaw AL, Fernández-del Castillo C. “Evolving patterns in the detection of pancreatic neuroendocrine tumors (PNETs): The Massachusetts General Hospital experience.” Podium presentation, 2006 Annual Meeting, New England Surgical Society, Groton, CT, September 15-17, 2006.

38. Vagefi PA, Razo O, Deshpande V, McGrath DJ, Lauwers GY, Thayer SP, Warshaw AL, Fernández-del Castillo C. “Evolving patterns in the detection of pancreatic neuroendocrine tumors (PNETs): The Massachusetts General Hospital experience.” Poster, 2006 APA-IAP Joint Meeting, Chicago, IL, November 1-4, 2006.

39. Alsina J, Stirman A, Mino-Kenudson M, Fernández-del Castillo C, Warshaw A, Thayer SP. “Shh misexpression in the adult pancreas results in the expansion of both a mucinous ductal metaplasia and a fibrosing mesenchyme.” Poster, 2006 APA-IAP Joint Meeting, Chicago, IL, November 1-4, 2006. Published in Pancreas 33(4):443 (2006).

40. Guimaraes AR, Rakhlin EY, Long D, Weissleder R, Thayer SP. “Noninvasive MRI imaging: A sensitive indicator of physiologic changes accompanied with anti-hedgehog therapy in a pancreatic ductal adenocarcinoma (PDAC) xenograft model.” Poster, 2006 APA-IAP Joint Meeting, Chicago, IL, November 1-4, 2006. Published in Pancreas 33(4):465-466 (2006).

41. LaFemina J, Stirman A, Alsina J, Mino-Kenudson M, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Challenging the role of the p16 mutation in the development of pancreatic adenocarcinoma.“ Presentation, 41st Annual Meeting, Pancreas Club, Washington, DC, May 20, 2007.

42. Alsina J, Stirman A, Mino-Kenudson M, Fernández-del Castillo C, Warshaw A, Thayer SP. “Sonic hedgehog misexpression directs epithelial and mesenchymal changes important in initiation of the pancreatic cancer phenotype.” 41st Annual Meeting, Pancreas Club, Washington, DC, May 20, 2007.

43. Crippa S, Salvia R, Warshaw AL, Dominguez I, Bassi C, Falconi M, Thayer SP, Zamboni G, Lauwers G, Mino-Kenudson M, Pederzoli P, Fernández-del Castillo C. “Mucinous cystic neoplasm of the pancreas is not an aggressive entity.” Lessons from 163 resected patients. 41st Annual Meeting, Pancreas Club, Washington, DC, May 20, 2007.

44. LaFemina J, Roberts P, Hung Y, Gusella J, Sahani D, Fernández-del Castillo C, Warshaw A, Thayer SP. “Identification of a novel kindred with familial pancreatitis and pancreatic cancer.” Poster, DDW& SSAT, Washington, DC, May 21, 2007 (Poster of Distinction).

Sarah P. Thayer, M.D., Ph.D. Page 29 45. LaFemina J, Roberts P, Hung Y, Gusella J, Sahani D, Fernández-del Castillo C, Warshaw

A, Thayer SP. “Identification of a novel kindred with familial pancreatitis and pancreatic cancer.” MGH Research Fellows’ Poster Celebration, Boston, MA, June 1, 2007 (Honorable Mention).

46. Fritz S. “Pancreatic cancer tumor response to Hedgehog pathway inhibition in a xenograft model.” Presentation, Karin Grunebaum Research Foundation, Harvard Medical School, Boston, MA, June 8, 2007.

47. Strobel O, Dor Y, Alsina J, Stirman A, Lauwers G, Trainor A, Fernández-del Castillo C, Warshaw A, Thayer S. “In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammation-mediated ductal metaplasia.” Presentation, Annual Meeting, APA, Chicago, IL, November 1-3, 2007.

48. LaFemina J, Stirman A, Alsina J, Mino-Kenudson M, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Paradoxical inhibition of ductal proliferation due to SHH misexpression with p16-/- is accompanied by pluripotential cell expansion.” Presentation, Annual Meeting, APA (Pancreatic Cancer 2007: Stem Cells in the Pancreas and Pancreatic Cancer), Chicago, IL, November 3, 2007; published in Pancreas 2007: 35(4):409-410.

49. LaFemina J, Stirman A, Alsina J, Mino-Kenudson M, Fernández-del Castillo C, Warshaw A, Thayer S. “Shh misexpression with p16-/- results in stimulation of pancreatic progenitor cells and paradoxical normalization of pancreatic neoplastic phenotype.” Poster, 54th Annual Meeting, Massachusetts Chapter, ACS, Boston, MA, December 8, 2007.

50. Fritz S, Fernández-del Castillo C, Mino-Kenudson M, Crippa S, Batten JM, Nguyen AT, Thayer SP, Deshpande V, Lauwers GY, Warshaw AL, Iafrate AJ. “Current chromosomal aberrations in intraductal papillary mucinous neoplasms (IPMNs).” Presentation, 42nd Annual Meeting, Pancreas Club, San Diego, CA, May 18, 2008.

51. Fritz S, Fernández-del Castillo C, Mino-Kenudson M, Crippa S, Miller JM, Thayer SP, Deshpande V, Lauwers GY, Warshaw AL, Iafrate AJ. “Detection of chromosomal aberrations in intraductal papillary mucinous neoplasms by comparative genomic hybridization.” Poster, DDW & 49th Annual Meeting SSAT, San Diego, CA, May 21, 2008.

52. Fritz S, Fernández-del Castillo C, Iafrate AJ, Mino-Kenudson M, Neyhard N, LaFemina J, Stirman A, Warshaw AL, Thayer SP. “A xenograft model and cell line deriving from invasive intraductal papillary mucinous neoplasm of the pancreas.” Poster, DDW & 49th Annual Meeting SSAT, San Diego, CA, May 19, 2008.

53. Ferrone CR, Warshaw AL, Rodriguez JR, Thayer SP, Fernández-del Castillo C. “Pancreatic fistula rates after 442 distal pancreatectomies: staplers do not decrease fistula rates.” Presentation, 49th Annual Meeting SSAT, San Diego, CA, May 20, 2008.

54. LaFemina J, Roberts P, Hung Y, Gusella J, Sahani D, Fernández-del Castillo C, Warshaw A, Thayer S. “Identification of a novel kindred with familial pancreatitis and pancreatic cancer.” Poster, 42nd Annual Meeting, Pancreas Club, San Diego, CA, May 18, 2008.

55. Strobel O, Rosow DE, Rakhlin EY, Lauwers GY, Trainor AG, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Pancreatic duct glands, a specialized ductal compartment reactive to chronic injury and involved in Shh-driven mucinous metaplasia.” Presented to the Joint Meeting of the European Pancreatic Club (EPC) and the IAP, Lodz, Poland, June 26, 2008.

Sarah P. Thayer, M.D., Ph.D. Page 30 56. Androutsopoulos V, Dominguez I, Ferrone C, Fernández-del Castillo C, Warshaw AL,

Thayer SP. “Does gemcitabine improve survival in resected pancreatic cancer patients?” Poster, Annual Meeting, APA, Chicago, IL, November 6-8, 2008.

57. Nehra D, Mino-Kenudson M, Thayer SP, Ferrone C, Finkelstein D, Silver M, Warshaw AL, Fernández-del Castillo C. “Intraductal papillary mucinous neoplasms: A genetic disease?” Poster, Annual Meeting, APA, Chicago, IL, November 6-8, 2008.

58. Konstantinidis I, Deshpande V, Catalano OA, Forcione DG, Sahani D, Fernández-del Castillo C, Thayer SP, Warshaw AL, Ferrone CR. “Lymphoepithelial cysts of the pancreas: Report of a single institution experience of 8 cases.” Poster, Annual Meeting, APA, Chicago, IL, November 6-8, 2008.

59. Correa-Gallego C, Ferrone C, Sahani D, Forcione D, Brugge W, Thayer SP, Warshaw AL, Fernández-del Castillo C. “Incidentally discovered pancreatic cysts: What evaluation is useful?” Presentation, Annual Meeting, APA, Chicago, IL, November 6-8, 2008.

60. Bausch D, Mino-Kenudson M, Warshaw AL, Thayer SP, Kelly K. “Plectin-1 as a novel imaging marker in pancreatic cancer.” Presentation, Annual Meeting, APA, Chicago, IL, Nov. 6-8, 2008.

61. Bausch D, Mino-Kenudson M, Fernández-del Castillo C, Warshaw AL, Thayer SP, Kelly K. “Plectin-1 as a novel imaging biomarker for pancreatic cancer.” Presentation, Pancreas Club, Chicago, IL, May 30, 2009.

62. Correa-Gallego C, Ferrone C, Thayer SP, Wargo JA, Warshaw AL, Fernández-del Castillo C. “Incidental pancreatic cysts: Do we really know what we are watching?” Presentation, Pancreas Club, Chicago, IL, May 30, 2009.

63. Androutsopoulos V, Thayer SP. “Does Gemzar improve survival in resected pancreatic cancer patients?” Presentation, Pancreas Club, Chicago, IL, May 31, 2009.

64. Konstantinidis I, Genevay M, Brugge WR, Thayer SP, Ferrone CR, Fernández-del Castillo C, Lauwers GY, Deshpande V. “Cytology plays a key role in the identification of malignancy in pancreatic cysts.” In analysis of 175 histologically confirmed cases. Presentation, DDW 2009, Chicago, IL (S1294).

65. Konstantinidis I, Deshpande V, Fernández-del Castillo C, Warshaw AL, Lauwers GY, Androutsopoulos V, Thayer SP, Ferrone CR. “Does the mechanism of lymph node invasion affect survival in patients with pancreatic cancer?” Presentation, DDW 2009, Chicago, IL (T1587).

66. Crippa S, Fernández-del Castillo C, Salvia R, Finkelstein DM, Bassi C, Dominguez I, Capelli P, Mino-Kenudson M, Lauwers TY, Falconi M, Thayer SP, Partelli S, Pederzoli, Warshaw AL. “Main-duct and combined IPMNs are the same clinical entity and distinct from branch-duct IPMNs.” Presentation, DDW 2009, Chicago, IL (967).

67. Fritz S, Fernández-del Castillo C, Mino-Kenudson M, Crippa S, Miller JM, Thayer SP, Deshpande V, Lauwers GY, Warshaw AL, Iafrate AJ. “Detection of chromosomal aberrations in intraductal papillary mucinous neoplasms by comparative genomic hybridization.” Presentation, DDW 2009, Chicago, IL (W1414).

68. Fritz S, Fernández-del Castillo C, Iafrate AJ, Mino-Kenudson M, Neyhard NL, LaFemina J, Stirman A, Warshaw AL, Thayer SP. “A xenograft model and cell line deriving from invasive intraductal papillary mucinous neoplasm of the pancreas.” Presentation, DDW, Chicago, IL, June 3, 2009.

Sarah P. Thayer, M.D., Ph.D. Page 31 69. Bausch D, Mino-Kenudson M, Fernández-del Castillo C, Warshaw AL, Kelly K, Thayer

SP. Plectin-1 as a biomarker in malignant pancreatic intraductal papillary mucinous tumors. Presentation, SSAT, DDW, Chicago, IL, June 3, 2009.

70. Boni A, Thayer SP, Ferrone C, Bausch D, Neyhard N, Cogdill A, Fernández-del Castillo C, Warshaw AL, Wargo JA. “Immunotherapeutic and epigenetic approaches targeting cancer-testis antigens in the treatment of pancreatic cancer.” Poster, Annual Meeting APA and Japanese Pancreas Society, Honolulu, HI, November 4-7, 2009.

71. Konstantinidis IT, Dursun A, Bordeianou L, Wargo J, Thayer SP, Fernández-del Castillo C, Warshaw AL, Ferrone CR. Metastatic tumors to the pancreas in the modern era. Poster, Annual Meeting APA and Japanese Pancreas Society, Honolulu, HI, November 4-7, 2009.

72. Ferrone CR, Konstantinidis IT, Fernández-del Castillo C, Wargo J, Thayer SP, Warshaw AL. “Fifteen years of the Warshaw technique.” Poster, Annual Meeting APA and Japanese Pancreas Society, Honolulu, HI, November 4-7, 2009.

73. Correa-Gallego C, Ferrone CR, Thayer SP, Wargo JA, Warshaw AL, Fernández-del Castillo C. “Are multifocal pancreatic cysts an indolent condition?” Poster, Annual Meeting APA and Japanese Pancreas Society, Honolulu, HI, November 4-7, 2009.

74. Correa-Gallego C, Mino-Kenudson M, Ferrone C, Thayer SP, Wargo JA, Warshaw AL, Fernández-del Castillo C. “Non-neoplastic cysts comprise 8% of resected pancreatic cysts presumed to be neoplastic.” Poster, Annual Meeting APA and Japanese Pancreas Society, Honolulu, HI, November 4-7, 2009.

75. Bausch D, Pausch T, Hopt UT, Fernández-del Castillo C, Warshaw AL, Thayer SP, Keck T. “Granulocyte MMP-9 is a VEGF-independent component of the angiogenic switch in PDAC.” Presentation, Annual Meeting APA and Japanese Pancreas Society, Honolulu, HI, November 4-7, 2009.

76. Bausch D, Fritz S, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Inhibition of hedgehog signaling in a PDAC xenograft model inhibits the tumor and its microenvironment.” Accepted for presentation (with Young Investigator Award), Joint Meeting, IAP and Japan Pancreas Society, Fukuoka, Japan, July 11-13, 2010.

77. Park JK, Irimia D, Toner M, Bausch D, Liss A, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Differences in migration between primary and metastatic PDAC cells.” Presentation (with Young Investigator Award), Joint Meeting IAP and Japan Pancreas Society Fukuoka, Japan, July 11-13, 2010.

78. Park JK, Toner M, Nagrath S, Komen J, Bausch D, Liss A, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Detection of circulating tumor cells (CTCs) in pancreatic ductal adenocarcinoma (PDAC).” Presentation (with Young Investigator Award), Joint Meeting IAP and Japan Pancreas Society Fukuoka, Japan, July 11-13, 2010.

79. Bausch D, Fritz S, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Inhibition of hedgehog signaling in a PDAC xenograft model inhibits the tumor and its microenvironment.” Presentation, Annual Meeting APA, Chicago, IL, November 3-6, 2010.

80. Park J, Irimia D, Toner M, Bausch D, Liss A, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Differences in migration between PDAC stem cells and non-stem cells.” Poster, Annual Meeting, APA, Chicago, IL, November 3-6, 2010.

Sarah P. Thayer, M.D., Ph.D. Page 32 81. Valsangkar NP, Bush DM, Michaelson JS, Fernández-del Castillo C, Warshaw AL,

Thayer SP. “Race does not substantially affect outcomes in patients with pancreatic cancer.” Poster, Annual Meeting, APA, Chicago, Nov. 3-6, 2010.

82. Valsangkar NP, Bush DM, Michaelson JS, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Prognostic value of lymph node ratio increases with number of lymph nodes examined: A concomitant review of SEER and a single institution’s patients.” Poster, 52nd Annual Meeting SSAT, DDW, Chicago, IL, May 6-10, 2011.

83. Valsangkar NP, Bush DM, Michaelson JS, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Predicting survival in pancreatic cancer: A comparison of lymph node ratio with number of metastatic nodes.” Presentation (short), Pancreas Club, DDW, Chicago, IL, May 6-10, 2011.

84. Bausch D, Fritz S, Liss A, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Hedgehog signaling is required for tumor stroma maintenance and tumor angiogenesis in pancreatic cancer.” Presentation (long), Pancreas Club, DDW, Chicago, IL, May 6-10, 2011.

85. Mino-Kenudson M, Fernández-del Castillo C, Baba Y, Hsu M, Correa-Gallego C, Ingkakul T, Perez Johnston R, Turner BG, Androutsopoulos V, McGrath D, Sahani DV, Brugge WR, Ogino S, Pitman MB, Warshaw AL, Thayer SP. “Prognostic significance of histologic and precursor epithelial subtypes of invasive intraductal papillary mucinous neoplasm: improved survival rates compared to pancreatic ductal adenocarcinoma are limited to indolent colloid and oncocytic types.” Presentation (long), Pancreas Club, DDW, Chicago, IL, May 6-10, 2011.

86. Valsangkar NP, Ingkakul T, Correa-Gallego C, Warshaw AL, Fernández-del Castillo C, Liss AS, Thayer SP. “The G12D mutation of KRAS predicts early recurrence and poor overall survival in ampullary adenocarcinoma.” Presented, Annual Meeting APA, Chicago, IL, November 2-5, 2011.

87. Yamaguchi J, Mino-Kenudson M, Liss AS, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Pancreatic duct glands (PDG) are the origin of gastric-type IPMN.” Poster, Annual Meeting APA, Chicago, IL, November 2-5, 2011.

88. Valsangkar NP, Ingkakul T, Correa-Gallego C, Liss AS, Mino-Kenudson M, Fernández-del Castillo C, Warshaw AL, Thayer SP. “The prognostic implication of KRAS mutation in ampullary adenocarcinoma: only the KRASG12D genotype predicts poor survival.” Presentation, 46th Annual Meeting, Pancreas Club, San Diego, CA, May 18-19, 2012.

89. Yamaguchi J, Mino-Kenudson M, Liss AS, Lillemoe KD, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Pancreatic duct glands (PDG) are the origin of gastric-type IPMN.” Presentation, 46th Annual Meeting, Pancreas Club, San Diego, CA, May 18-19, 2012.

90. Liss AS, Nahar S, Mertz JA, Sims RJ, Fernández-del Castillo C, Lillemoe KD, Warshaw AL, Thayer SP. “The BET family of chromatin adaptors are key regulators of cell growth and Shh expression in pancreatic ductal adenocarcinoma.” Presentation and Poster of Distinction, 46th Annual Meeting, Pancreas Club, San Diego, CA, May 18-19, 2012.

91. Kulemann B, Liss AS, Valsangkar NP, Fernández-del Castillo C, Lillemoe KD, Mino-Kenudson M, Warshaw AL, Pitman MB, Thayer SP. “The capture of CTC for cytological, molecular and cell culture evaluation in patients with pancreatic cancer.” Poster of Distinction, 46th Annual Meeting, Pancreas Club, San Diego, CA, May 18-19, 2012.

Sarah P. Thayer, M.D., Ph.D. Page 33 92. Hedgire Sandeep S, Fernández-del Castillo Carlos, Thayer Sarah, Mino-Kenudson Mari,

Weissleder Ralph, Harisinghani Mukesh G. “Delineating the tumor in pancreatic adenocarcinoma using USPIO-ferumoxytol: Preliminary findings.” Annual Meeting, Society of Computed Body Tomography and Magnetic Resonance, Boston, MA, October 6, 2012. Best Translational Science Poster Award.

93. Yamaguchi J, Mino-Kenudson M, Liss AS, Lillemoe KD, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Pancreatic duct glands (PDG), a progenitor stem cell niche responsible for pancreatic epithelial renewal and repair in response to inflammatory injury.” Poster, Joint Meeting, APA and IAP, Miami, FL, October 31-November 3, 2012.

94. Sahora K, Mino-Kenudson M, Thayer S, Ferrone C, Brugge W, Sahani D, Pitman M, Warshaw A, Lillemoe K, Fernández-del Castillo C. “Branch duct intraductal papillary mucinous neoplasms: Does cyst size change at the tip of the scale? A critical analysis of the revised international consensus guidelines in a large single-institutional series.” Presentation, American Surgical Association, 133rd Annual Meeting, Atlanta, GA, April 4-6, 2013.

95. Ven FZ, Klaus S, Seefeld KJ, Wargo JA Ferrone CR, Thayer SP, Warshaw AL, Lillemoe KD, Hutter MM, Fernández-del Castillo C. “Understanding hospital readmissions after pancreaticoduodenectomy: can we prevent them? A 10-year contemporary experience with 1173 patients at the Massachusetts General Hospital.” Plenary presentation, Annual Meeting SSAT, Orlando, FL, May 17, 2013.

96. Goldberg S, Hong TS, Fernández-del Castillo C, Thayer SP, Ferrone CR, Willett C, Warshaw AL, Ryan DP, Cai S. “IORT prognostic factors for locally advanced pancreatic cancer.” Poster, American Society for Radiation Oncology (ASTRO), 55th Annual Meeting, Atlanta, GA, Sept. 22-24, 2013.

97. Cauley CE, Pittman M, Zhou J, Valsangkar N, Liss A, Fernández-del Castillo C, Warshaw AL, Lillemoe KD, Thayer SP. “Prognostic value of circulating tumor cells in patients with pancreatic adenocarcinoma.” 44th Annual Meeting APA, Miami Beach, FL, Oct. 31-Nov. 2, 2013.

98. Yamaguchi J, Mino-Kenudson M, Liss AS, Lillemoe KD, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Loss of TFF2 in pancreatic duct glands (PDG) results in the formation of IPMN, suggesting TFF2 may function as a tumor suppressor.” 44th Annual Meeting APA, Miami Beach, FL, October 31-November 2, 2013.

99. Marchegiani G, Mino-Kenudson M, Morales-Oyarvide V, Thayer S, Ferrone C, Warshaw AL, Lillemoe K, Fernández-del Castillo C. “IPMN involving the main pancreatic duct: biology, epidemiology, and long-term outcomes following resection.” 44th Annual Meeting APA, Miami Beach, FL, October 31-November 2, 2013.

100. Liss AS, Nahar S, Mertz J, Bryant B, Sims R III, Fernández-del Castillo C, Lillemoe K, Warshaw AL, Thayer SP. “BET proteins are key mediators of tumor cell growth and the microenvironment in pancreatic cancer.” 44th Annual Meeting APA, Miami Beach, FL, October 31-November 2, 2013.

101. Chowdhury S, Klinkebiel D, Yamaguchi J, Liss AS, and Thayer SP. “TFF2/Smad4 tumor suppressor signaling in pancreatic cancer is regulated by promoter methylation.” 46th APA Annual Meeting, San Diego, CA, November 4-7, 2015 (Poster of Distinction)

102. Chowdhury S, Ali M, Yamaguchi J, Liss AS, Sontheimer A, and Thayer SP. “Novel TFF2/DPYSL3 interaction in Smad4-mediated tumor suppressor signaling in pancreatic cancer.” 46th APA Annual Meeting, San Diego, CA, November 4-7, 2015.

Sarah P. Thayer, M.D., Ph.D. Page 34 103. Chowdhury S, Ali M, Maroni D, Woods N, and Thayer SP. “DPYSL3 variant 1 regulates

cell survival in pancreatic cancer.” 46th American Pancreatic Association (APA) Annual Meeting, San Diego, CA, November 4-7, 2015.

104. Thayer SP. “The ampulla is a reservoir for Lgr5-derived secretory cells that migrate to the pancreas following injury,” 46th Annual Meeting of APA, San Diego, CA, November 4-7, 2015

Professional and Public Service Engagements Nov 2014 “Interview with an Expert: Surgery.” Published in Cure Pancreatic

Cancer, Lustgarten Foundation. www.lustgarten.org Jan 20, 2015 Opening remarks at the Pre-radio-thon Meeting for NRG Media, Omaha,

NE Mar 2, 2015 Interview for video for NRG Media Radio-thon Mar 2, 2015 Interview for NET program, “Living with Cancer in Nebraska” Mar 7, 2015 Represented the F&PBCC at the Team Jack Gala in Lincoln, NE Mar 21, 2015 Attended the Ambassador of Hope Gala Mar 25, 2015 Participated in a Panel Discussion for NET program on cancer in

Nebraska Apr 17, 2015 Represented the F&PBCC at Kicks for a Cure Apr 18, 2015 Represented the F&PBCC at the Omaha Symphony Gala Oct 9, 2015 Interview for the Midlands Business Journal Oct 27, 2015 Participated/Photos for the UNe Campaign Jan 13, 2016 Interviewed by the Omaha World Herald for an article which appeared

on Jan 14, 2016 Jan 13, 2016 Interviewed by KETV for video story: “Cancer cure plays important role

with local family” Jan 20, 2015 Opening remarks at the Pre-Radio-Thon Meeting for NRG Media Mar 2, 2015 Interview for video for NRG Media Radio-Thon Mar 2, 2015 Interview for NET TV Program, “Living with Cancer in Nebraska” Mar 7, 2015 Represented the F&PBCC at the Team Jack Gala in Lincoln, NE Mar 21, 2015 Represented the F&PBCC at the Ambassador of Hope Gala Mar 25, 2015 Participated in a Panel Discussion in Lincoln, NE, for an NET Program on

cancer in Nebraska Apr 17, 2015 Represented the F&PBCC at Kicks for a Cure Apr 18, 2015 Represented the F&PBCC at the Omaha Symphony Gala, Omaha, NE Oct 9, 2015 Provided a statement and photo for the “Midlands Business Journal” Oct 27, 2015 Participated in a UNe campaign Oct 28, 2015 Interviewed with Sue Myer for a new F&PBCC publication Jan 13, 2016 Interviewed by the Omaha World Herald for an article which appeared on

January 14, 2016, entitled, “Education Cure is a ‘mighty word,’ but emerging science, Obama’s encouragement holds promise for cancer patients, Omaha docs say.”

Jan 13, 2016 Interviewed by TV station, KETV, for video story: “Cancer cure effort plays important role with local family.”

Feb 2, 2016 Participated in a marketing photoshoot for the Multidisciplinary Clinic (MDC)

http://www.lustgarten.org/

Sarah P. Thayer, M.D., Ph.D. Page 35 Feb 13-15, 2016 Presentation concerning the F&PBCC at the NU Foundation event in

Scottsdale, AZ Mar 8, 2016 Participated in a physician recruitment video shoot for Provider Network

Services Apr 25, 2016 Participated in an outreach dinner with St. Francis Medical Center, Grand

Island, NE May 17, 2016 Attended the Mother/Daughter Brunch to discuss women’s cancer

services, Omaha, NE July 13, 2016 Presented at the Optum Health Conference, Century Link Center,

Omaha, NE July 22, 2016 Attended the American Cancer Society’s Hope in the Heartland Gala at

Baxter Arena, Omaha, NE Sept 12, 2016 Attended an outreach dinner with Heartland Oncology & Hematology. Oct 3, 2016 Traveled to Lincoln, NE, to provide an update to Senators and President

Hank Bounds concerning the F&PBCC during pre-game activities. Also presented brief remarks on the Half Time Radio Network with Dr. Bounds concerning the current status of the cancer center’s opening, as well as cancer research and care

Oct 1, 2016 Social share, “The Buffett Cancer Center is recruiting the best of the best—researchers and physicians in top positions at national-level programs and prestigious institutions. They see what we’re doing for cancer care and research, and they want to be part of it.”

Oct 2016 Included in an advertisement for the University of Nebraska to detail the F&PBCC, https://nebraska.edu/impact/.

https://nebraska.edu/impact/

Documents

I. GENERAL INFORMATION2014- American Society of Clinical Oncology (ASCO) 2015- Society of Surgical Oncology (SSO) 2015- American Society of Breast Surgeons (ASBS) Awards and Honors: