i Bd Compar Compet Trials

7/23/2019 i Bd Compar Compet Trials

http://slidepdf.com/reader/full/i-bd-compar-compet-trials 1/17

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Cevac IBD L comparison to competitorsCevac IBD L comparison to competitors

Comparative studies of Cevac IBD L and some

of its main competitors

Results

C. Cazaban

International Technical Manager



2


Stud !o." #D$%&"'%(&&)* +. ,orgach- safet and serolog response

in S/, birds

10-day old SPF birds.

Ocular vaccination with

• Nobilis 228E (co!"titor 1#$ or

• %& (co!"titor 2#$

•'"vac &) *.

+0 birds !"r ,rou! (incl. control ,rou!#




Kinetics of virus replication in the bursa of Fabricius in 10-day oldSPF birds (study no.1)

0

1

2

3

!

"

2 3 # 1! 21

$ays of the study

% u r s a

h i s t o l o & y s c o r e ( ' u

r P h )

opetitor 1 opetitor 2 evac *%$ + ontrols




%,% inde in 10-day old SPF birds on $2 (study no.1)

0

0/1

0/2

0/3

0/

0/!

0/"

0/#

%% inde

opetitor 1 opetitor 2 evac *%$ +

*nterediate

ot



/


Serolo&y curve in 10-day old SPF birds (study no.1)

0123

!"#

10111213

0 # 1! 21 2

$ays of the study

* %

$ t i t r e ( i n l o &

2 )

opetitor 1 opetitor 2 evac *%$ + ontrols

*

*

*: statistical di fference





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Stud !o.( Immunosuppression stud #D$0&"10(&&)* $. /ala-

11-day old SPF birds. /0 birds !"r ,rou!.

Ocular vaccination ()ay 0# with

• Nobilis 228E (co!"titor 1#$• %& (co!"titor 2#$

• Poulvac &ursa Plus (co!"titor #$

• &) &l"n (co!"titor #$ or

• '"vac &) *.

Ocular vaccination with '"vac ni * day .

N) chall"n," (9"rts strain$ 10+ E)/0 !"r bird$ by i# day 18.

N) chall"n," ass"ss"nt day 2.



:


%,% inde in 11-day old SPF birds on $32 (study no.2)

0

0/1

0/2

0/3

0/

0/!

0/"

0/#

%% indeopetitor 1 opetitor 2 opetitor 3 opetitor evac *%$ +

*nterediate

ot



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*%$ Serolo&y curve in 11-day old SPF birds (study no.2)

0

1

23

!

"

#

10

11

12

13

0 1 32

$ays of the study

* % $ t i t r e ( i n l o &

2 )

opetitor 1 opetitor 2 opetitor 3 opetitor evac *%$ + ontrols

*

*

*: statistical di fference

*%$ vaccination



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$ Serolo&y curve in 11-day old SPF birds

0

1

2

3

!

"

#

0 1 32

$ays of the study

$ 0 * t i t r e ( i n l o & 2 )

op 1 4 5ni + op 2 4 5ni + op 3 4 5ni + op 4 5ni + evac *%$ + 4 5ni + evac 5ni + ontrols

*

*: statistical difference

*%$ vaccination $ vaccination



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$ challen&e in 11-day old SPF birds100 100 100 100 100 100

0

0

10

20

30

0

!0

"0

#0

0

0

100

P r o t e c t i o n r a t e ( 6 )

op 1 4 5ni + op 2 4 5ni + op 3 4 5ni + op 4 5ni + evac *%$ + 4 5ni + evac 5ni + SPF controls

$0, *%$ vaccination

$, $ vaccination

$1, $ challen&e

$32, $ challen&e

assessent



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7ise in * titre follo8in& $ challen&e in 11-day old SPF birds

0

0/!

1

1/!

2

2/!

3

3/!

$ 3 2 t i t r e i n c h a l l e n & e d -

$ 3 2 t i t r e i n u n c h a l l e n & e d

b i r d s

op 1 4 5ni + op 2 4 5ni + op 3 4 5ni + op 4 5ni + evac *%$ + 4 5ni + evac 5ni +

$0, *%$ vaccination

$, $ vaccination

$1, $ challen&e

$32, $ challen&e assessent





1/


Stud !o.) #D$%()0(&&) $. /ala- safet and efficac in commercialbroilers

'o"rcial broil"rs$ ocularly vaccinat"d at 17 days o a," (%); <N

titr" hatch 12.8$ and 17 d : lo,2# with (12/ birds !"r ,rou!3 1+/

controls#• Nobilis 228E (co!"titor 1#

• ;bic %& (co!"titor 2#

• Poulvac &ursa Plus (co!"titor #

• &) &l"n (co!"titor #

• '"vac &) *

vv&) chall"n,"$ %O9: strain$ 10 E)/0 !"r bird (20 birds !"r ,rou!#$

oral rout".



1+


evac *%$ + in broilers, coparison to copetitors, &ro8th

0

!00

1000

1!00

2000

2!00

3000

1 21 2 3! 2

9&e of the chic:ens (days)

9 v e r a & e b o d y 8 e i &

h t ( & )

opetitor 1 opetitor 2 opetitor 3 opetitor evac *%$ + ontrol

accination at 1# days

of a&e



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evac *%$ + in broilers, coparison to copetitors, vv*%$ challen&eresults

0

10

20

30

0

!0

"0

#0

0

0

100

1st challen&e ($2) 2nd challen&e ($32)

irus replication in the bursa days after challen&e

' t e n t o f b u r s

a

i n v o l v e e n t i n 6 )

opetitor 1 opetitor 2 opetitor 3 opetitor evac *%$ + ontrol



1:


%ain conclusions

• '"vac &) * is sa" on th" ,rowth o th" co"rcial broil"rs.

• Followin, th" "arli"st chall"n," (7 days !-v$ birds a,"d 2 days#$

'"vac &) * (and &) &l"n# !rot"ct"d th" bursa3 228E$ %&$ or

Poulvac &ursa Plus did not.

• Followin, th" lat" chall"n," (1/ days !-v$ birds a,"d 2 days#$

'"vac &) * (and %& and Poulvac &ursa Plus# !rot"ct"d a,ainstilln"ss$ as "vid"nc"d by th" body w"i,ht ,ain3 &) &l"n or 228E

did not. ;ll vaccin"s siilarly !rot"ct"d th" bursa.

Documents

i Bd Compar Compet Trials