Spring 2011 Saint Louis University School of Medicine

GrandRounds

Internal Medicine Celebrates Centennial Match Day New Advocate for Faculty Development

Spring 2011 Saint Louis University School of Medicine

GrandRounds

Internal Medicine Celebrates Centennial Match Day New Advocate for Faculty Development

Spring 2011 Saint Louis University School of Medicine

GrandRounds

Internal Medicine Celebrates Centennial Match Day New Advocate for Faculty Development

For more information about the magazine or to submit story

suggestions, please contact 314 | 977-8335 or

grandrounds@slu.edu.

Vol. 9 No. 1 Saint Louis University School of MedicineSpring 2011

Grand Rounds is published biannually by

Saint Louis UniversityMedical Center

Development and Alumni Relations.

Grand Rounds is mailed to alumni and friends of the

School of Medicine.

Philip O. Alderson, M.D.Dean | Saint Louis University

School of MedicineVice President | Health Sciences

Schwitalla Hall M2681402 S. Grand Blvd.

St. Louis, MO 63104-1028

Grand rounds Editorial BoardPhilip O. Alderson, M.D.

Edward J. O’Brien Jr., M.D. ’67Thomas J. Olsen, M.D. ’79

Coordinator and writEr

Marie Dilg | SW ’94

dEsiGnErDana Hinterleitner

ContriButorsLaura Geiser | A&S ’90 | Grad ’92

Nancy SolomonCarrie Bebermeyer | Grad ’06

Sara Savat | Grad ’04

Photo CrEditsSteve Dolan | 12, 16, 20 and back cover

Sara Savat | Grad ’04 | 3, 14Kabance Photography | 20

Chad Williams | A&S ’11 | 2

© 2011, Saint Louis University All rights reserved

From the Dean | Medical education in America was much different in the early years of the 20th century than it is today. Many so-called medical schools were small, for-profit operations that provided two-year apprenticeships taught by part-time teach-ers. Admission and graduation requirements were lax. Because of concerns about this, the American Medical Association licensed the Carnegie Foundation to study and report on the American medical education system. The results of that study, which was conducted and written by Abraham Flexner, dramatically changed the future of America’s medical schools. Flexner wrote that the model for American education should be more like that of Johns Hopkins, which was modeled after European schools. Hopkins had taken the lead in the European style of medical training, which was grounded in scientific principles and supported by full-time faculty members. After the Flexner Report, many of the small proprietary programs closed. Standards for admission and graduation in America’s medical schools became much more rig-orous, and full-time professors were recruited. Because the new, well-organized curricula required better organizational support, the strongest university-associated medical schools began to de-velop accountable institutional units. These organization entities are what we now know as medical departments, and SLU was one of the early adopters. In 1911, within one year after the Flexner Report, SLU formed its Department of Medicine (known now as “Internal Medicine”). The first 100 years of this department have been characterized by the type of strong, science-based educa-tion that Flexner advocated. In addition, biomedical research at SLU has been closely linked to education to keep the level of instruction at the leading edge. SLU’s medical students tradition-ally learn not only the theory of medicine, but how to apply these principles in compassionate practice. These goals, which are quite consistent with those of Flexner, remain vital as we celebrate the centennial of that first department at SLU. Flexner’s report changed American medicine. A century later, SLU continues to evolve and improve its efforts to educate the finest young physi-cians possible. This issue of Grand Rounds is dedicated to the celebration of that century-long commitment in our Department of Medicine.

Philip o. alderson, M.d.Dean | Saint Louis University School of Medicine Vice President | Health Sciences

standing outside the Doisy Research Center

Mechanisms for Meeting the MisionNew dean of faculty de-velopment strives to give physicians and reserchers a voice | page 12

Poised for Discovery Young researchers waste no time in attracting attention and funding | page 16

Make Me a MatchMembers of the Class of 2011 get their marching orders| page 14

Vital signs | page 2

alumni Pulse and living the Mission | page 18

why i Give| back cover

page 4

page 16

page 12

page 14

page 2

GrandRounds

For more information about the magazine or to submit story

suggestions, please contact 314 | 977-8335 or

grandrounds@slu.edu.

Vol. 9 No. 1 Saint Louis University School of MedicineSpring 2011

Grand Rounds is published biannually by

Saint Louis UniversityMedical Center

Development and Alumni Relations.

Grand Rounds is mailed to alumni and friends of the

School of Medicine.

Philip O. Alderson, M.D.Dean | Saint Louis University

School of MedicineVice President | Health Sciences

Schwitalla Hall M2681402 S. Grand Blvd.

St. Louis, MO 63104-1028

Grand rounds Editorial BoardPhilip O. Alderson, M.D.

Edward J. O’Brien Jr., M.D. ’67Thomas J. Olsen, M.D. ’79

Coordinator and writEr

Marie Dilg | SW ’94

dEsiGnErDana Hinterleitner

ContriButorsLaura Geiser | A&S ’90 | Grad ’92

Nancy SolomonCarrie Bebermeyer | Grad ’06

Sara Savat | Grad ’04

Photo CrEditsSteve Dolan | 12, 16, 20 and back cover

Sara Savat | Grad ’04 | 3, 14Kabance Photography | 20

Chad Williams | A&S ’11 | 2

© 2011, Saint Louis University All rights reserved

From the Dean | Medical education in America was much different in the early years of the 20th century than it is today. Many so-called medical schools were small, for-profit operations that provided two-year apprenticeships taught by part-time teach-ers. Admission and graduation requirements were lax. Because of concerns about this, the American Medical Association licensed the Carnegie Foundation to study and report on the American medical education system. The results of that study, which was conducted and written by Abraham Flexner, dramatically changed the future of America’s medical schools. Flexner wrote that the model for American education should be more like that of Johns Hopkins, which was modeled after European schools. Hopkins had taken the lead in the European style of medical training, which was grounded in scientific principles and supported by full-time faculty members. After the Flexner Report, many of the small proprietary programs closed. Standards for admission and graduation in America’s medical schools became much more rig-orous, and full-time professors were recruited. Because the new, well-organized curricula required better organizational support, the strongest university-associated medical schools began to de-velop accountable institutional units. These organization entities are what we now know as medical departments, and SLU was one of the early adopters. In 1911, within one year after the Flexner Report, SLU formed its Department of Medicine (known now as “Internal Medicine”). The first 100 years of this department have been characterized by the type of strong, science-based educa-tion that Flexner advocated. In addition, biomedical research at SLU has been closely linked to education to keep the level of instruction at the leading edge. SLU’s medical students tradition-ally learn not only the theory of medicine, but how to apply these principles in compassionate practice. These goals, which are quite consistent with those of Flexner, remain vital as we celebrate the centennial of that first department at SLU. Flexner’s report changed American medicine. A century later, SLU continues to evolve and improve its efforts to educate the finest young physi-cians possible. This issue of Grand Rounds is dedicated to the celebration of that century-long commitment in our Department of Medicine.

Philip o. alderson, M.d.Dean | Saint Louis University School of Medicine Vice President | Health Sciences

standing outside the Doisy Research Center

Mechanisms for Meeting the MisionNew dean of faculty de-velopment strives to give physicians and reserchers a voice | page 12

Poised for Discovery Young researchers waste no time in attracting attention and funding | page 16

Make Me a MatchMembers of the Class of 2011 get their marching orders| page 14

Vital signs | page 2

alumni Pulse and living the Mission | page 18

why i Give| back cover

page 4

page 16

page 12

page 14

page 2

On the coverMuch of the School of Medicine’s rich history is rooted in the Depart-ment of Internal Medicine, which is celebrating its 100th anniver-sary this year. This cover of Grand Rounds honors the department’s chairmen: Charles Hugh Neilson, M.D., Ralph A. Kinsella Sr., M.D., Goronwy O. Broun Sr., M.D., Rene Wegria, M.D., Thomas F. Frawley, M.D., Stephen M. Ayers, M.D., Coy Fitch, M.D., D. Douglas Miller, M.D., and Adrian Di Bisceglie, M.D. Enjoy more archival photos, along with the department’s timeline and faculty memories on page 6.

GrandRounds

VitalSigns

tetri

lim

hoft

3 Grand Rounds

Construction continues on the Education union at the Medical Center. The building — located next to the School of Nursing — is being renovated and expanded to include a student lounge, a study space, a 225-seat auditorium, a state-of-the-art patient simulation center and an area for food service. It is scheduled to be completed by this summer.

Prescription for a Brighter FutureMedical School Students Teach At-Risk Teens

Jeremy timm a fourth-year medical student at SLU, leads a hands-on lesson about the makeup of the human brain and the effects cigarettes, illegal drugs and alcohol have on it.

Internal Medicine Announces New Division DirectorsBrent Tetri, M.D.Tetri, a SLUCare hepatologist with the Saint Louis University Liver Center, has been named director of the division of gastroenterology and hepatology.

Tetri is a distinguished hepatologist with an international reputation in the area of non-alcoholic fatty liver disease. He came to SLU in 1991 as an assistant professor of internal medicine.

Tetri is a graduate of Yale School of Medicine and completed an internship and residency at the University of Wisconsin Hospital and Clinics in Madison, Wis. He completed subspecialty training in gastroenterology and hepatology at the University of California San Francisco and the UCSF Liver Center Laboratory.

Tetri is the principal investigator at SLU for the NASH CRN (Nonalcoholic Steatohepatitis Clinical Research Network), which is funded by the NIH. Grants

from this network, which is currently in its second funding cycle, have brought approximately $6 million to the University.

vaccination with an H5 strain that isn’t the current dominant strain.”

In anticipation of a bird flu pandemic, in 2004 the U.S. government stockpiled 20 million doses of vaccine against the “Vietnam” strain of avian influenza, which then was the dominant strain of the virus. But the avian flu changes quickly, and since then a different strain of bird flu, known as the “Indonesia” strain, has replaced the Vietnam strain as the prominent circulating avian flu.

Researchers studied both the vaccine against the Vietnam strain and an investigational vaccine designed to protect against the Indonesia strain in 491 healthy adults. They measured the body’s immune response to different combinations of the two avian flu vaccines. They also looked at how long to wait between giving the first and second doses of vaccine.

Stockpiled Avian Flu Vaccine Could be Used Against New Strain A stockpiled vaccine designed to fight a strain of avian flu that circulated in 2004 can be combined with a vaccine that matches the current strain of bird flu to protect against a potential pandemic, researchers from the University’s Center for Vaccine Development have found.

The findings in the March issue of the Journal of Infectious Diseases suggest public health officials can get a jump on fighting a pandemic caused by avian flu virus because they won’t have to wait for a vaccine that exactly matches the current strain of bird flu to be manufactured. They can begin immunizing against the bird flu by giving an injection of a vaccine made from a related, yet mismatched, strain of flu to prime the body for a second shot of a vaccine that matches the current strain.

“A cornerstone of pandemic planning is the development of effective vaccines against avian influenza infection,” said Robert Belshe, M.D., director of the Center for Vaccine Development and the lead author of the paper. “The results of the present study confirm the usefulness of

Michael Lim, M.D.Lim, a SLUCare cardiologist, has been named director of the division of cardiology.

Lim is a national leader in the area of interventional cardiology. He came to SLU in 2003 as an assistant professor of internal medicine and has served as director of the catheterization labs at SLU Hospital.

After graduating from Wayne State University School of Medicine and completing his residency at Indiana University,

Lim served as chief medical resident at the Veterans Administration Medical Center in Indianapolis. He completed his training in cardiology and a fellowship in interventional cardiology at the University of Michigan.

Lim has conducted extensive clinical research using devices and other interventions in the management of coronary heart disease and congestive heart failure, as part of both large multi-center clinical trials and as an independent investigator at SLU.

Daniel F. Hoft, M.D., Ph.D. Hoft has been named director of the division of infectious diseases, allergy and immunology. The new division merges the division of immunobiology, which Hoft previously had directed, with the division of infectious diseases.

Hoft, who joined the medical school as an assistant professor of internal medicine in 1992, is a renowned researcher in

They found that two doses of vaccine are needed to provide protection against the avian flu. Giving the stockpiled Vietnam avian flu vaccine as the first dose primed the body’s system so that a follow up dose of the investigational Indonesia avian flu vaccine triggered a heightened immune response. The immune response to both strains of avian influenza became more robust as the injections of vaccine were spaced further apart.

“A 180-day interval between priming and boosting vaccine doses gave the best antibody responses, although in a fast-moving pandemic, this is unlikely to be an option,” Belshe said.

“The most surprising thing we discovered was the value of time,” he said. “It’s incredible how much stronger response you get at six months. There’s something going on there that we know nothing about and is a very interesting area for future research.”

the areas of immunology, infectious diseases and vaccine development. He is an internationally recognized tuberculosis vaccine expert. In addition, his research has led to the development of new vaccines in pre-clinical development for Chagas disease, a major cause of cardiac and gastrointestinal problems throughout Latin America.

Hoft is a graduate of the University of Missouri-Columbia’s School of Medicine. He received his Ph.D., from the University of Iowa, where he also was a resident and a fellow in infectious diseases.

Hoft has played a leadership role in the School of Medicine’s M.D./Ph.D. program. He has served as principle investigator for eight NIH grants, co-investigator

for more than six other NIH grants, and principal investigator of 12 TB vaccine clinical trials. He also has

participated in numerous NIH review committees for research grants and served as an adviser to the World Health Organization and other international bodies.

Every Thursday morning, a handful of fourth-year medical school students take a break from their busy study schedules to teach high school anatomy. Their students are not typical high school students, though.

The students at Innovative Concept Academy (ICA) have been suspended or expelled from school for a variety of offenses ranging from drug possession to gang activity. They come to ICA — often as an alternative to jail time — for a chance to turn their lives around.

Through SLU’s Adventures in Medicine and Science (AIMS) pro-gram, ICA students learn about the three main systems of the human body: nervous, circulatory and skeletal systems. Fourth-year medical students teach 11 one-hour programs at ICA per semester. The initia-tive is in its second semester.

“The medical school students are what set this program apart,” said Lisa Suggs, AIMS program manager. “They’re more than teach-ers; they’re role models. Many of the at-risk students at ICA have no positive role models in their lives. But the medical school students are close to their age, they’re real and down-to-earth. This experience is really powerful for ICA students.”

On the surface, the program looks like a typical high school anatomy class. But teachers hope to go one step further. The goal is to make science exciting and approachable. Their message: Anyone can do this; you just have to work hard.

To reinforce the message that a career in science is within reach, the teachers talk about why they chose to go to medical school. They share stories from their lives. They talk about applying to countless un-dergraduate programs and not getting into their first, or even second, choice school. They talk about not giving up and working hard, but still finding time for the occasional video game. They also talk about the excitement of working in a field where they’ll have the opportunity to help people and make a real difference.

“I think this program has surpassed everyone’s initial expecta-tions,” said Annie LeClair, AIMS program assistant. “The medical school students have gotten so much out of teaching at ICA and the high school students are thriving in the AIMS program. Several students have shown a real interest in careers in medical science. It’s definitely a win-win.”

To learn more about the AIMS program, go to aims.slu.edu.

VitalSigns 5 Grand Rounds Saint Louis University School of Medicine

Thirsty for More? Vital Signs contains only a fraction of the news and events taking place at SLU’s Medical Center. If you would like to know more, check out SLU Health News on Facebook. Once you “like” SLU Health News, you can get updates in your Facebook news feed and participate in discussions.

facebook.com/SLUHealth

Grandgenett

Six Honored with Caring Physician AwardsDuring an interfaith prayer service in October celebrating the Feast of St. Luke, Saint Louis University Hospital recognized six doctors with Caring Physician Awards. The recipients included (from left) Erin l. Bakanas, M.d., general internal medicine; Mary s. Burton, M.d., gastroenterology and hepatology; nadia wasi-iqbal, M.d., nephrology; stewart G. albert, M.d., endocrinology; and rodney E. Yarnal, M.d., housestaff resident. The late Frank r. Burton, M.d., gastroenterology and hepatology was recognized posthumously.

The winners were selected from 30 nominations submitted by at-tending, fellow and resident physicians for demonstrating the qualities of caring, compassionate physicians.

Cannada

VitalSigns

SLU Virologist Receives an Outstanding Scientist AwardThe Academy of Science-St. Louis is giving Duane Grandgenett, Ph.D., professor at SLU's Institute of Molecular Virology, the Fellows Award, which recognizes a distinguished individual for outstanding achievement in science.

Grandgenett is a pioneering researcher whose basic science discoveries about how retroviruses spread have lead to new treatments for HIV. For more than three decades, he has focused on integrase, an enzyme that starts a process that allows HIV to put its genetic material into a person’s DNA, which leads to the spread of infected cells.

Grandgenett is considered the “father of integrase” because he was the first to characterize the structure and mechanism of the enzyme, which is a critical step in understanding the retrovirus life cycle.

Building on his studies and those of other investigators, a pharmaceutical company has developed a new and effective medication for HIV/AIDS, which afflicts about 33 million people worldwide.

‘Un-Growth Hormone’ Increases LongevityA research team has shown that a compound that acts in the opposite way as growth hormone can reverse some of the signs of aging. The finding may be counter-intuitive to some older adults who take growth hormone, thinking it will help revitalize them.

The result is significant, said John E. Morley, M.D., study co-investigator and director of the divisions of geriatric medicine and endocrinology, because people sometimes take growth hormone, believing it will be the fountain of youth.

“Many older people have been taking growth hormone to rejuvenate themselves,” Morley said. “Our results strongly suggest that growth hormone, when given to middle aged and older people, may be hazardous.”

The scientists studied the compound MZ-5-156, a “growth hormone-releasing hormone (GHRH) antagonist.” They conducted their research in a mouse strain engineered for studies of the aging process. Overall, the researchers found that MZ-5-156 had positive effects on oxidative stress in the brain, improving cognition, telomerase activity (the actions of an enzyme which protects DNA material) and life span, while decreasing tumor activity.

MZ-5-156, like many GHRH antagonists, inhibited several human cancers, including prostate, breast, brain and lung cancers. It also had positive effects on learning, and is linked to improvements in short-term memory. The antioxidant actions led to less oxidative stress, reversing cognitive impairment in the aging mouse.

brain function, rather than structure.

Bucholz said the time is right for this project because advances in imaging, cloud computing and genetics have brought scientists to a point where they can make sense of the enormous amounts of data required to study the human brain.

“This is a fascinating study that could at last offer a better understanding of a brain’s wiring,” said Bucholz, who also is director of the division of neurosurgery.

Researchers will study those with healthy brains, including identical twins, to learn how much of our brains' wiring is formulated by genetics as opposed to the environment.

Researchers hope to learn how much variance there is between normal brains. And, once the roadmap has been determined, they hope to use that information to help those with brain or neurological injuries or illness.

Improving Treatment of Battlefield Injuries One of two dozen major trauma centers named to be a part of the Department of Defense-funded Major Extremity Trauma Research Consortium (METRC), Saint Louis University will work to improve treatment for wounded service members and civilians. The partnership aims to conduct research to improve the care of major orthopaedic injuries sustained on the battlefield.

The consortium recently received a grant of $38.6 million, building on an initial

allotment of $18.4 million to improve the care of service members.

Lisa Cannada, M.D., associate professor

of orthopaedic surgery, said the studies conducted by consortium members will shed new light on the effectiveness of current treatment methods.

“We’ll be able to better understand what works and what doesn’t in treating both service members and civilians,” said Cannada.

SLU is one of a network of core civilian trauma centers that will work with major military medical centers. The consortium aims to improve evidence-based treatment guidelines for orthopaedic injuries, improving the clinical, functional and quality of life outcomes for both service members and civilians who suffer orthopaedic injuries.

Cannada, who is principal investigator for the consortium at SLU, is leading a study examining bone grafts.

William A. Banks, M.D., formerly at SLU and now a professor of internal medicine and geriatrics at the University of Washington School of Medicine in Seattle, is the study’s lead author. He said the results led the SLU team “to determine that antagonists of growth hormone-releasing hormone have beneficial effects on aging.”

National Children’s Study Starts The National Children’s Study, the largest study ever conducted in the United States to learn about the health and development of children, has begun in St. Louis.

Led in the St. Louis region by SLU’s School of Public Health, the study will follow more than 100,000 children from before birth until age 21. It will examine the effects of the environment and genetics on the growth, development and health of children.

“The ultimate goal of the study is to improve the health and well-being of children. We believe the National Children's Study will guide public health policies and the treatment of children for generations to come,” said Louise Flick, Dr.P.H., principal investigator for the National Children’s Study Gateway Study Center and professor of epidemiology at the School of Public Health.

Washington University in St. Louis, Southern Illinois University Edwardsville and the Battelle Center for Public Health Research and Evaluation, St. Louis Office, are collaborating partners with SLU in the St. Louis region.

Children from Jefferson County, Mo.; Macoupin County, Ill.; and Johnson/

Neurosurgeon Scans Brains for Landmark Wiring MapAs a part of a $30 million NIH initiative to functionally map the human brain, SLU neurosurgeon Richard Bucholz, M.D., will image the brains of healthy adults with magnetoencephalogram (MEG) technology, providing key information about brain function.

Collaborating with Washington University in St. Louis and the University of Minnesota’s Center for Magnetic Resonance Research, the institutions that lead the Human Connectome project, Bucholz’ team will head up the MEG imaging component of the endeavor as researchers aim to create a map of the cognitive pathways of the human brain.

Used clinically in only a handful of facilities throughout the country, the MEG, housed at SLU Hospital, is a key part of the Human Connectome project, offering data about

Union/Williamson counties, Ill.; which are other communities in the Gateway Study Center, will be recruited in 2012 as the study expands nationally to include a total of 105 study locations. Ultimately, more than 4,000 children from the Gateway Study Center will be sought for the research.

The National Children’s Study is funded by the NIH, CDC and the EPA. As the lead regional site, Saint Louis University School of Public Health received a total of $53.1 million – representing one 5-year contract for $26.8 million in 2007 and two 5-year contracts totaling $26.3 million in 2008 – from the NIH and other federal agencies.

Medical School Joins National Research Transformation EffortThe School of Medicine has joined a regional initiative funded by a $50 million, five-year NIH grant designed to speed the translation of basic science discoveries into treatments and cures for patients.

Washington University School of Medicine received the Clinical and Translational Science Award (CTSA) in 2007 to lead a regional collaboration that’s part of a national effort to foster research bridging the gap

between laboratory science and patient care.

Original collaborators on the team led by Washington University include BJC HealthCare; University of Missouri-St. Louis; Southern Illinois University Edwardsville; St. Louis College of Pharmacy and Saint Louis University’s schools of public health and nursing, Albert Gnaegi Center for Health Care Ethics and Doisy College of Health Sciences. Last fall, Saint Louis University School of Medicine was added as a collaborating partner.

“The CTSA promotes collaboration among institutions,” said Raymond Tait, Ph.D., vice president for research at SLU and a member of the CTSA Governing Council. “The idea is if we can put our mutual resources together, we will each be more productive in answering the question, ‘How do you translate a discovery into something that yields value for the community?’”

CTSA grants, which have been awarded to institutions in 28 states and the District of Columbia, also support training a new generation of clinical and translational researchers and engaging communities in research. Once the national research initiative is fully implemented this year, there will be about 60 CTSAs across the country.

5 Grand Rounds Saint Louis University School of Medicine

Thirsty for More? Vital Signs contains only a fraction of the news and events taking place at SLU’s Medical Center. If you would like to know more, check out SLU Health News on Facebook. Once you “like” SLU Health News, you can get updates in your Facebook news feed and participate in discussions.

facebook.com/SLUHealth

Grandgenett

Six Honored with Caring Physician AwardsDuring an interfaith prayer service in October celebrating the Feast of St. Luke, Saint Louis University Hospital recognized six doctors with Caring Physician Awards. The recipients included (from left) Erin l. Bakanas, M.d., general internal medicine; Mary s. Burton, M.d., gastroenterology and hepatology; nadia wasi-iqbal, M.d., nephrology; stewart G. albert, M.d., endocrinology; and rodney E. Yarnal, M.d., housestaff resident. The late Frank r. Burton, M.d., gastroenterology and hepatology was recognized posthumously.

The winners were selected from 30 nominations submitted by at-tending, fellow and resident physicians for demonstrating the qualities of caring, compassionate physicians.

Cannada

In 1911, there were no antibiotics.No immunizations against childhood diseases. No blood pressure medications.

No effective treatments for heart disease, cancer or ulcers. Roentgenographs (x-rays) were coming into use but were considered

more of a novelty than a diagnostic tool.

In 1911, medical education was digesting the Flexner Report,which called for improved admission and graduation standards, and full-time professors.

Medical educators and private practitioners were beginning to set aside their hostility and recognize each other’s legitimacy.

And in 1911, Saint Louis University’s School of Medicine established what would become one of its largest departments, the

Department of Internal Medicine.

Known at different times as Medicine, or as Experimental Medicine and Therapeutics, the Department of Internal Medicine started with a dozen physicians who were jacks-of-all-trades and grew into a department with nearly 130 full-time medical specialists in 10 divisions — cardiology; endocrinology; gastroenterology and hepatology; general

internal medicine; geriatrics; hematology and medical oncology; infectious diseases, allergy and immunology; nephrology; pul-monary, critical care and sleep medicine; and rheumatology.

As part of the department’s year-long centennial celebration, a different division

is featured every month with daily health tips on St. Louis radio station KEZK-FM

102.5; the divisions are sponsoring health literacy programs through the St. Louis County Library and news of special department events and stories are carried on digital display boards throughout the Medical Center and on the SLUCare website. A special exhibit of archival materials is on display outside the Medical Center Library.

“We’re very proud of our heritage as the oldest univer-sity west of the Mississippi and the part our department of internal medicine plays in increasing the prestige of the University,” said Adrian Di Bisceglie, M.D., chair of the department of internal medicine and holder of the Badeeh A. and Christine V. Bander Chair in Internal Medicine.

You can follow the department’s rise to national and international prominence by tracing its timeline.100exceence

Department of Internal Medicine Celebrates a Century of Compassionate Care

YEARS OF

Laurence J. KinseLLa, M.D. (’85)Neurologist | SSM St. Clare

Following a fruitful career investigating streptococcal infection and endocarditis at the Rockefeller Institute, my grandfather, Dr. Ralph A. Kinsella Sr., returned to St. Louis in 1919 to establish a research institute at Jewish Hospital. He returned to SLU in 1924 as professor of experimental medicine and the physician-in-chief of the newly constructed St. Mary’s Hospi-tal. Together with his friend and collaborator, Dr. Goronwy Broun, he would go on to publish seminal works in inflammatory arthritis, bacterial endocarditis, and St. Louis Encephalitis.

Ralph produced a slew of Kinsella physicians – Ralph Jr. (endocrinologist and chief of staff at City Hospital), Edward (gastroenterologist at St. Mary’s) and Peter (pulmonologist at St. Mary’s). A generation of nurses at St. Mary’s would help young trainees distinguish the Drs. Kinsella as “Endoscopy Ed” and “Pulmonary Pete.”

Ralph Jr. and Peter married physicians as well: Margaret Boyle, M.D., and Maria Stack, M.D., respectively.

The current generation of Kinsella physicians includes Margaret (Maggie), a rheumatologist in Bellingham, Wash.; Laurence, an adjunct professor in neurology at SLU and a neurologist at SSM St. Clare; and Charles, a pulmonary/critical care specialist in Indianapolis. And already, the fourth generation has begun. Christopher Ralph Jr., M.D. (Ed’s grandson and my nephew) will be a surgical resident at SLU in July. In addition to all of these physicians, we can’t forget the many nurses in the Kinsella family including Jane Ann, Kathy and Maria.

I think Ralph would want today’s physicians to recall what a privilege it is to practice medi-cine, to remain vigilant to variations in disease presentation and to remain ardent students of the science of medicine.

1900s

1903 SLU acquires the Marion-Sims-Beau-mont College of Medicine, resuming medical education the University had ceased in 1855.

1910s

1911 Charles Hugh Neilson, M.D., is appoint-ed director of the department of medicine.

1918 The first wave of an influenza pandemic hits the nation, killing more than 20 million people — more than had been killed in WWI.

1919 Ralph A. Kinsella Sr., M.D. (’11), joins the School of Medicine as a professor in the department of medicine. He receives a federal grant to study infectious diseases. To help in-vestigate the influenza pandemic, he recruits recent School of Medicine graduate Goronwy O. Broun Sr., M.D. (’18), whose sister died from the virus. Together they discover the factors responsible for hemorrhaging in severe cases.

The department has 26 part-time faculty members.

6 Grand Rounds

Deep Roots: The Kinsella Legacy

100exceenceDepartment of Internal Medicine Celebrates a Century of Compassionate Care

YEARS OF

Laurence J. KinseLLa, M.D. (’85)Neurologist | SSM St. Clare

Following a fruitful career investigating streptococcal infection and endocarditis at the Rockefeller Institute, my grandfather, Dr. Ralph A. Kinsella Sr., returned to St. Louis in 1919 to establish a research institute at Jewish Hospital. He returned to SLU in 1924 as professor of experimental medicine and the physician-in-chief of the newly constructed St. Mary’s Hospi-tal. Together with his friend and collaborator, Dr. Goronwy Broun, he would go on to publish seminal works in inflammatory arthritis, bacterial endocarditis, and St. Louis Encephalitis.

Ralph produced a slew of Kinsella physicians – Ralph Jr. (endocrinologist and chief of staff at City Hospital), Edward (gastroenterologist at St. Mary’s) and Peter (pulmonologist at St. Mary’s). A generation of nurses at St. Mary’s would help young trainees distinguish the Drs. Kinsella as “Endoscopy Ed” and “Pulmonary Pete.”

Ralph Jr. and Peter married physicians as well: Margaret Boyle, M.D., and Maria Stack, M.D., respectively.

The current generation of Kinsella physicians includes Margaret (Maggie), a rheumatologist in Bellingham, Wash.; Laurence, an adjunct professor in neurology at SLU and a neurologist at SSM St. Clare; and Charles, a pulmonary/critical care specialist in Indianapolis. And already, the fourth generation has begun. Christopher Ralph Jr., M.D. (Ed’s grandson and my nephew) will be a surgical resident at SLU in July. In addition to all of these physicians, we can’t forget the many nurses in the Kinsella family including Jane Ann, Kathy and Maria.

I think Ralph would want today’s physicians to recall what a privilege it is to practice medi-cine, to remain vigilant to variations in disease presentation and to remain ardent students of the science of medicine.

1900s

1903 SLU acquires the Marion-Sims-Beau-mont College of Medicine, resuming medical education the University had ceased in 1855.

1910s

1911 Charles Hugh Neilson, M.D., is appoint-ed director of the department of medicine.

1918 The first wave of an influenza pandemic hits the nation, killing more than 20 million people — more than had been killed in WWI.

1919 Ralph A. Kinsella Sr., M.D. (’11), joins the School of Medicine as a professor in the department of medicine. He receives a federal grant to study infectious diseases. To help in-vestigate the influenza pandemic, he recruits recent School of Medicine graduate Goronwy O. Broun Sr., M.D. (’18), whose sister died from the virus. Together they discover the factors responsible for hemorrhaging in severe cases.

The department has 26 part-time faculty members.

6 Grand Rounds

Deep Roots: The Kinsella Legacy

's

9 8 Grand Rounds

John c. soucy Jr., M.D. (’61)Internist | Private Practice

My father, John C. Soucy Sr., M.D., was one of the first four residents to graduate from the internal medicine’s ac-credited residency program in 1932.

He often told me stories of the legendary diagnostic skills of his director and teacher, Dr. Ralph Kinsella. He said Dr. Kinsella could walk into the room of a complex and challenging patient and “smell” the diagnosis. The residents under Dr. Kinsella were well trained and masters of physical diagnosis. My father practiced internal medicine for more than 40 years in East St. Louis, Ill. He often made house calls in exchange for parts of a chicken, eggs, produce or other commodities. He became well known as a diagnostician and often was consulted in the most challenging cases.

From my memory and the testimo-nies of patients, he made many life-sav-ing diagnoses of atypical presentations of diseases such as tularemia, typhoid, Rocky Mountain spotted fever, subdural hematomas, pancreatitis, severe hypogly-cemia with coma and other entities. Re-member, there were no CT scans, MRIs, guided needle biopsies or other “high tech” resources. And, clinical laboratory diagnostic testing was in its infancy and considered archaic by today’s standards.

JaMes r. DraKeProfessor | Division of General Internal Medicine | 35 years

When I arrived at SLU in 1976 I was one of only three physicians in the primary care section, later to become general internal medicine. The Doctor’s Office Building was nearly new with color-coded modules. The old colored tiles still are visible in the back halls. I shared an office with Dr. Broun Sr., one of three generations of Brouns to be in the department during my time. Dr. William Dunn was my immediate boss.

We were a hospital unit in terms of finances but had academ-ic appointments in the department. Often there were conflicting priorities between the hospital (Mr. Richard Stensrud) and the department (Dr. Stephen Ayers), which would leave us caught in the middle. It wasn’t until 1987 when Dr. Coy Fitch took us into the department as the division of general medicine that we felt fully a part of the department. Dr. Robert Heaney was brought from City Hospital to be the first division director. To-day the division of general internal medicine has 13 physicians at the University Hospital. Over the years I have had the privilege of attending while my current colleagues Drs. Heaney, Olsen, Walden, Maxwell, Porter, Rice, Buckhold and Chako were stu-dents and/or residents in training.

By the way, I’m probably the only person currently at the University who actually ever met Dr. Charles Hugh Neilson. He was the grandfather of a close friend I’ve known since childhood.

raLph a. KinseLLa sr., M.D. (’11), was the first to demonstrate that salicylates, such as aspirin, have anti-inflammatory effects. He also made a major contri-bution to the understanding of the pathogenesis of infective endocarditis.

J. F. GerarD MuDD, M.D. (’45), established the first major cardiac cath-eterization laboratory in St. Louis in 1951, thus beginning landmark clinical research that continues today.

GeorGe e. ThoMa, M.D. (’47), professor emeritus in the division of nuclear medicine and vice president for the medical campus (1973-86), was a pioneer in the use of radio-isotopes in diagnosis and was the first editor of the Journal of Nuclear Medicine.

John MorLey, M.D., and JaMes FLooD, ph.D., were the first to estab-lish a mouse model of Alzheimer’s disease, which has allowed them to develop revolu-tionary therapies that appear to reverse the memory deficits in these animals by blocking production of beta-amyloid. Morley and his team also are leading studies on hormone replacement therapy to treat and/or prevent some of the problems of aging. One of their most significant findings showed that testosterone therapy could improve memory and strength in elderly men.

The Division oF inFecTious Diseases has received federal funding as a Vaccine Treatment and Evaluation Unit for two decades. One of eight NIAID-funded vac-cine research centers, the division is studying the safety and efficacy of several vaccines including potential vaccines against various strains of flu and TB.

Bruce r. Bacon, M.D., played a critical role in the discovery of the gene responsible for hemochromatosis. He and his team also are pioneering combination drug therapies for patients with chronic hepatitis C.

1920s

1924 Kinsella, also known as “Big Red,” is appointed director of the department of medicine and physi-cian-in-chief of the University Hospitals, which consists of St. Mary’s Hospital, St. Mary’s Infirmary and Mt. St. Rose Hospital.

Associated hospitals include Alexian Brothers, St. Anthony’s and St. John’s.

Broun, who left the school to work with some of the most famous virologists of the time, returns to the University and becomes the first full-time faculty member in the department.

1925 The department of medicine is re-named the department of internal medicine and has 40 faculty members.

1927 Rev. Alphonse Schwitalla, S.J., is appointed dean of the School of Medicine, and Neilson is appointed associate dean the following year.

1930s

1930 The University formally establishes grad-uate fellowships in internal medicine, which marks the beginning of formalized training in internal medicine at SLU. These positions were filled by men who had completed their medical degrees and had at least one year of approved internship. The two-year program provided physicians with the opportunity “for intensive development both in the fundamen-tal and the clinical sciences, fitting him more adequately for his future work as a physician.”

1931 Broun is pro-moted to professor of internal medicine.

The department has 48 faculty members.

1932 Graduate fellowships are des-ignated to honor the memory of persons

intimately associated with the development of the school. Honorees in internal medicine include the William Banks Rogers, the Mother Seraphia, the Don R. Joseph and the William Beaumont Graduate Fellowships in Internal Medicine.

1950s

1951 J. F. Gerard Mudd, M.D. (’45), estab-lishes the Cardiac Catheterization Lab.

1952 Mary Frances Nawrocki, M.D., is the first woman to graduate from the School of Medicine.

1954 Broun becomes chairman of the depart-ment of internal medicine. The John Cochran Veterans Administration Medical Center opens and becomes an important part of the department’s clinical, teaching and research activities. The relationship continues today.

1958 Broun retires and is succeeded by Rene Wegria, M.D. as chairman

1960s

1961 Broun emerges from retirement to become dean of the School of Medicine.

1964 Thomas F. Frawley, M.D., suc-ceeds Wegria.

1965 The division of allergy is created with the hiring of Raymond Slavin, M.D. (’56).

1966 The internal medicine residency program is accredited by the Accreditation Council on Graduate Medical Education.

1970s

1975 Stephen M. Ayres, M.D., is ap-pointed chairman of the department.

1977 The department establishes the divi-sion of endocrinology.

1980s

1981 The combined internal medicine and pediatrics residency training program is established.

in memory of a father

BROUN

KIN

SELL

A

FRAWLEY

WEG

RIA

AYR

ES

1933-38 Broun’s research into encephalitis brings national attention to the department. Broun was the first to isolate the viral agent responsible for St. Louis Encephalitis.

1933 Firmin Desloge Hospital is opened, supplanting St. Mary’s Infirmary as the chief teaching center of the medical school. The hospital was owned jointly by the Sisters of St. Mary and the University until 1959.

The Graduate Board authorizes the conferring of the degree of master in internal medicine, in place of the previously conferred degree, master of science in inter-nal medicine.

1936 The American Board of Internal Medicine con-venes for the first time, and the first internists are certified. Neilson is the first from SLU’s School of Medicine to be certified.

1940s

1940 Faculty increases to 66 members. Broun becomes director of laboratories.

1946 After WWII, the hospital board increases the number of residencies to meet the demands of returning medical officers. Resi-dencies in internal medicine increased from three to nine.

1949 Neilson retires. The same year, Melvin A. Casberg, M.D., succeeds Schwitalla as dean of the school. Three women are admitted to the school.

9 8 Grand Rounds

John c. soucy Jr., M.D. (’61)Internist | Private Practice

My father, John C. Soucy Sr., M.D., was one of the first four residents to graduate from the internal medicine’s ac-credited residency program in 1932.

He often told me stories of the legendary diagnostic skills of his director and teacher, Dr. Ralph Kinsella. He said Dr. Kinsella could walk into the room of a complex and challenging patient and “smell” the diagnosis. The residents under Dr. Kinsella were well trained and masters of physical diagnosis. My father practiced internal medicine for more than 40 years in East St. Louis, Ill. He often made house calls in exchange for parts of a chicken, eggs, produce or other commodities. He became well known as a diagnostician and often was consulted in the most challenging cases.

From my memory and the testimo-nies of patients, he made many life-sav-ing diagnoses of atypical presentations of diseases such as tularemia, typhoid, Rocky Mountain spotted fever, subdural hematomas, pancreatitis, severe hypogly-cemia with coma and other entities. Re-member, there were no CT scans, MRIs, guided needle biopsies or other “high tech” resources. And, clinical laboratory diagnostic testing was in its infancy and considered archaic by today’s standards.

JaMes r. DraKeProfessor | Division of General Internal Medicine | 35 years

When I arrived at SLU in 1976 I was one of only three physicians in the primary care section, later to become general internal medicine. The Doctor’s Office Building was nearly new with color-coded modules. The old colored tiles still are visible in the back halls. I shared an office with Dr. Broun Sr., one of three generations of Brouns to be in the department during my time. Dr. William Dunn was my immediate boss.

We were a hospital unit in terms of finances but had academ-ic appointments in the department. Often there were conflicting priorities between the hospital (Mr. Richard Stensrud) and the department (Dr. Stephen Ayers), which would leave us caught in the middle. It wasn’t until 1987 when Dr. Coy Fitch took us into the department as the division of general medicine that we felt fully a part of the department. Dr. Robert Heaney was brought from City Hospital to be the first division director. To-day the division of general internal medicine has 13 physicians at the University Hospital. Over the years I have had the privilege of attending while my current colleagues Drs. Heaney, Olsen, Walden, Maxwell, Porter, Rice, Buckhold and Chako were stu-dents and/or residents in training.

By the way, I’m probably the only person currently at the University who actually ever met Dr. Charles Hugh Neilson. He was the grandfather of a close friend I’ve known since childhood.

raLph a. KinseLLa sr., M.D. (’11), was the first to demonstrate that salicylates, such as aspirin, have anti-inflammatory effects. He also made a major contri-bution to the understanding of the pathogenesis of infective endocarditis.

J. F. GerarD MuDD, M.D. (’45), established the first major cardiac cath-eterization laboratory in St. Louis in 1951, thus beginning landmark clinical research that continues today.

GeorGe e. ThoMa, M.D. (’47), professor emeritus in the division of nuclear medicine and vice president for the medical campus (1973-86), was a pioneer in the use of radio-isotopes in diagnosis and was the first editor of the Journal of Nuclear Medicine.

John MorLey, M.D., and JaMes FLooD, ph.D., were the first to estab-lish a mouse model of Alzheimer’s disease, which has allowed them to develop revolu-tionary therapies that appear to reverse the memory deficits in these animals by blocking production of beta-amyloid. Morley and his team also are leading studies on hormone replacement therapy to treat and/or prevent some of the problems of aging. One of their most significant findings showed that testosterone therapy could improve memory and strength in elderly men.

The Division oF inFecTious Diseases has received federal funding as a Vaccine Treatment and Evaluation Unit for two decades. One of eight NIAID-funded vac-cine research centers, the division is studying the safety and efficacy of several vaccines including potential vaccines against various strains of flu and TB.

Bruce r. Bacon, M.D., played a critical role in the discovery of the gene responsible for hemochromatosis. He and his team also are pioneering combination drug therapies for patients with chronic hepatitis C.

1920s

1924 Kinsella, also known as “Big Red,” is appointed director of the department of medicine and physi-cian-in-chief of the University Hospitals, which consists of St. Mary’s Hospital, St. Mary’s Infirmary and Mt. St. Rose Hospital.

Associated hospitals include Alexian Brothers, St. Anthony’s and St. John’s.

Broun, who left the school to work with some of the most famous virologists of the time, returns to the University and becomes the first full-time faculty member in the department.

1925 The department of medicine is re-named the department of internal medicine and has 40 faculty members.

1927 Rev. Alphonse Schwitalla, S.J., is appointed dean of the School of Medicine, and Neilson is appointed associate dean the following year.

1930s

1930 The University formally establishes grad-uate fellowships in internal medicine, which marks the beginning of formalized training in internal medicine at SLU. These positions were filled by men who had completed their medical degrees and had at least one year of approved internship. The two-year program provided physicians with the opportunity “for intensive development both in the fundamen-tal and the clinical sciences, fitting him more adequately for his future work as a physician.”

1931 Broun is pro-moted to professor of internal medicine.

The department has 48 faculty members.

1932 Graduate fellowships are des-ignated to honor the memory of persons

intimately associated with the development of the school. Honorees in internal medicine include the William Banks Rogers, the Mother Seraphia, the Don R. Joseph and the William Beaumont Graduate Fellowships in Internal Medicine.

1950s

1951 J. F. Gerard Mudd, M.D. (’45), estab-lishes the Cardiac Catheterization Lab.

1952 Mary Frances Nawrocki, M.D., is the first woman to graduate from the School of Medicine.

1954 Broun becomes chairman of the depart-ment of internal medicine. The John Cochran Veterans Administration Medical Center opens and becomes an important part of the department’s clinical, teaching and research activities. The relationship continues today.

1958 Broun retires and is succeeded by Rene Wegria, M.D. as chairman.

1960s

1961 Broun emerges from retirement to become dean of the School of Medicine.

1964 Thomas F. Frawley, M.D., suc-ceeds Wegria.

1965 The division of allergy is created with the hiring of Raymond Slavin, M.D. (’56).

1966 The internal medicine residency program is accredited by the Accreditation Council on Graduate Medical Education.

1970s

1975 Stephen M. Ayres, M.D., is ap-pointed chairman of the department.

1977 The department establishes the divi-sion of endocrinology.

1980s

1981 The combined internal medicine and pediatrics residency training program is established.

in memory of a father

BROUN

KIN

SELL

A

FRAWLEY

WEG

RIA

AYR

ES

1933-38 Broun’s research into encephalitis brings national attention to the department. Broun was the first to isolate the viral agent responsible for St. Louis Encephalitis.

1933 Firmin Desloge Hospital is opened, supplanting St. Mary’s Infirmary as the chief teaching center of the medical school. The hospital was owned jointly by the Sisters of St. Mary and the University until 1959.

The Graduate Board authorizes the conferring of the degree of master in internal medicine, in place of the previously conferred degree, master of science in inter-nal medicine.

1936 The American Board of Internal Medicine con-venes for the first time, and the first internists are certified. Neilson is the first from SLU’s School of Medicine to be certified.

1940s

1940 Faculty increases to 66 members. Broun becomes director of laboratories.

1946 After WWII, the hospital board increases the number of residencies to meet the demands of returning medical officers. Resi-dencies in internal medicine increased from three to nine.

1949 Neilson retires. The same year, Melvin A. Casberg, M.D., succeeds Schwitalla as dean of the school. Three women are admitted to the school.

a proud past1985 Coy Fitch, M.D., is appointed acting chairman of the department of internal medi-cine. In 1988 he is named chairman.

1985 St. Louis City Hospital closes.

1987 The University Hospital is expanded with the building of Bordley Tower. The division of general internal medicine is established and plays an instrumental role in developing the comprehensive, affordable University Health Plan for students and families.

1988 The division of geriatric medicine is cre-ated, and internationally known gerontological researcher, clinician and educator, John E. Morley, M.D., is appointed director.

1989 Fitch recruits Robert Belshe, M.D. (infectious diseases) and, a year later, Bruce R. Bacon, M.D. (gastroenterology and hepatol-ogy) as division directors, thus beginning significant education, research and clinical expansions in their specialties.

1990s

1996 Patricia Mon-teleone, M.D., (’61) is named first woman dean of the School of Medicine.

1998 Saint Louis Uni-versity Hospital is sold to Tenet Healthcare Corp.

10 Grand Rounds

Terry Moore, M.D. (’72)Professor | Director of the Division of Rheumatology | 35 years

I have enjoyed my time at SLU immensely and would like to express gratitude to the people who have helped me along the way. This includes: 1) Dr. Stephen Ayres, the former department chairman, who recruited me back here and gave me the time to pur-sue my research and achieve NIH funding; 2) Dr. Jack Zuckner, my longtime mentor and first director of rheumatology who guided me in my early days on the faculty; 3) Dr. Raymond Slavin, who has been a colleague and provided guidance throughout the years; 4) Dr. Adrian Di Bisceglie, our pres-ent chairman who again provided support for our division.

Also, I would like to express my gratitude to Ms. Margery Fort and Elizabeth and Chris Dorr who have provided funding over the last seven years for our research through their Campbell-Avery and Dorr Family Trust Funds, as well as thanks to John Fischer and the Lupus and Juvenile Arthritis Group of St. Louis for helping in our fundraising.

sTewarT aLBerT, M.D.Professor | Division of Endocrinology | 33 years

Dr. Coy Fitch established the division of endocrinology in 1977. I arrived a year later, Dr. Alan Silverberg in 1979 and Dr. Marla Bernbaum in 1983.

During the 30 plus years, the peripatetic division has wandered its offices with-in the medical center complex by moving eight times. One permanency, however, has been a goal emanating from the endocrinology division directors: residents and fellows should be internists first. As Dr. Harold Rifkin, past president of the American Diabetes Association said, “to know diabetes, you must know internal medicine.” We have had outstanding researchers and educators as directors — Drs. Coy Fitch, Arshag Mooradian, John Morley. More critically, these outstanding clinicians have set the standard for medical care regarding both evidence-based medicine and the art of “treating always.”

This seriousness, though, must be tempered and, as in all great works, there must be comic relief. The division’s physicians, fellows and staff star in an annual play that is a parody of medicine, health care and politics. Fortunately, the politi-cians keep us well stocked with material. The plays have ranged from Star Trek, Sherlock Holmes, Hamlet, Inherit the Wind and culminated (when there was suf-ficient talent or bravado) with a fractured musical version of The Wizard of Oz. We hope the inevitable “bonding” will keep us in touch with our graduates.

rayMonD G. sLavin, M.D., (’56)Professor | Director of Allergy and Clinical Immunology | 46 years

Washington University had left City Hospital that summer, and SLU remained. In July, the city experienced 17 consecutive days of temperatures above 100 de-grees. The ER was the only area with air conditioning. Many patients experienced heat stroke in the hospital! A heat stroke room set up next to the ER was filled with patients immersed in ice. More then 700 patients were admitted with heat stroke, and 150 people died in St. Louis during that heat wave.

Ten days into the scorching heat, Scott Air Force Base sent over a desert team with jet engines to run compressors that generated cold air to be piped into the wards. It was quite a sight to see an enormous tent housing the jet engines in front of the hospital.

There were no private rooms — only large wards with beds on the periphery. On each ward another row of beds was set up in the middle of the room. I can remember going down to City Hospital to see consults and lecture and feeling exactly like I was in a sauna.

All faculty members participated, but particularly yeoman services were rendered by Drs. Bob Heaney, Bill Mootz and Don Kennedy. Everyone who was at City Hospital during that period, including medical students, was invited to a party at Dr. Steve Ayres’ home, who then was chairman of the department. We were given a blue pin with 1980 emblazoned on it. Several weeks later at medicine grand rounds at the LRC, Dr. Ayres asked all of the people from City Hospital to stand amidst thunderous applause.

MON

TELE

ONE

remembering the 1980 heat wave

a little comic relief

In graditude

A Proud Past — A Bright FutureA Word From the Chairman

A Bright Future - A Word From the Chairman Adrian M. Di Bisceglie, M.D.

2000's

2000 D. Douglas Miller, M.D. (Bus ’99) , is named chairman of the department.

2001 Saint Louis University Liver Center is established. It becomes the larg-est liver center in Missouri in terms of

research funding, patient visits, clinical trials and hepatologists. It has the most active Hepatitis C practice in the United States.

2006 World renowned hepatologist Adrian M. Di Bisceglie, M.D., is appointed acting chair-man of the department. In 2009 Di Bisceglie is named chair and inaugural holder of the Badeeh A. and Christine V. Bander Chair in Inter-nal Medicine.

2008 The University opens the new Edward A. Doisy Research Center.

The department has grown to:

128 full-time faculty 275 part-time faculty 103 residents 75 fellows

Faculty members serve as attending physi-cians at Saint Louis University Hospital, the Veterans Administration Medical Center, SSM St. Mary’s Health Center and Des Peres Hospital.

The department generated more than $15.5 million in externally funded research in 2010.

MILLER

DI B

ICSE

GLIE

in honor oF Dr. coy FiTch, the physician who helped lead SLU’s department of internal medicine to prominence, the Fitch family has established the Drs. Coy D. and Rachel F. Fitch Endowed Lectureship Fund. Gifts to this fund can be made using the envelope which appears in this magazine.

a proud past1985 Coy Fitch, M.D., is appointed acting chairman of the department of internal medi-cine. In 1988 he is named chairman.

1985 St. Louis City Hospital closes.

1987 The University Hospital is expanded with the building of Bordley Tower. The division of general internal medicine is established and plays an instrumental role in developing the comprehensive, affordable University Health Plan for students and families.

1988 The division of geriatric medicine is cre-ated, and internationally known gerontological researcher, clinician and educator, John E. Morley, M.D., is appointed director.

1989 Fitch recruits Robert Belshe, M.D. (infectious diseases) and, a year later, Bruce R. Bacon, M.D. (gastroenterology and hepatol-ogy) as division directors, thus beginning significant education, research and clinical expansions in their specialties.

1990s

1996 Patricia Mon-teleone, M.D., (’61) is named first woman dean of the School of Medicine.

1998 Saint Louis Uni-versity Hospital is sold to Tenet Healthcare Corp.

10 Grand Rounds

Terry Moore, M.D. (’72)Professor | Director of the Division of Rheumatology | 35 years

I have enjoyed my time at SLU immensely and would like to express gratitude to the people who have helped me along the way. This includes: 1) Dr. Stephen Ayres, the former department chairman, who recruited me back here and gave me the time to pur-sue my research and achieve NIH funding; 2) Dr. Jack Zuckner, my longtime mentor and first director of rheumatology who guided me in my early days on the faculty; 3) Dr. Raymond Slavin, who has been a colleague and provided guidance throughout the years; 4) Dr. Adrian Di Bisceglie, our pres-ent chairman who again provided support for our division.

Also, I would like to express my gratitude to Ms. Margery Fort and Elizabeth and Chris Dorr who have provided funding over the last seven years for our research through their Campbell-Avery and Dorr Family Trust Funds, as well as thanks to John Fischer and the Lupus and Juvenile Arthritis Group of St. Louis for helping in our fundraising.

sTewarT aLBerT, M.D.Professor | Division of Endocrinology | 33 years

Dr. Coy Fitch established the division of endocrinology in 1977. I arrived a year later, Dr. Alan Silverberg in 1979 and Dr. Marla Bernbaum in 1983.

During the 30 plus years, the peripatetic division has wandered its offices with-in the medical center complex by moving eight times. One permanency, however, has been a goal emanating from the endocrinology division directors: residents and fellows should be internists first. As Dr. Harold Rifkin, past president of the American Diabetes Association said, “to know diabetes, you must know internal medicine.” We have had outstanding researchers and educators as directors — Drs. Coy Fitch, Arshag Mooradian, John Morley. More critically, these outstanding clinicians have set the standard for medical care regarding both evidence-based medicine and the art of “treating always.”

This seriousness, though, must be tempered and, as in all great works, there must be comic relief. The division’s physicians, fellows and staff star in an annual play that is a parody of medicine, health care and politics. Fortunately, the politi-cians keep us well stocked with material. The plays have ranged from Star Trek, Sherlock Holmes, Hamlet, Inherit the Wind and culminated (when there was sufficient talent or bravado) with a fractured musical version of The Wizard of Oz. We hope the inevitable “bonding” will keep us in touch with our graduates.

rayMonD G. sLavin, M.D., (’56)Professor | Director of Allergy and Clinical Immunology | 46 years

Washington University had left City Hospital that summer, and SLU remained. In July, the city experienced 17 consecutive days of temperatures above 100 de-grees. The ER was the only area with air conditioning. Many patients experienced heat stroke in the hospital! A heat stroke room set up next to the ER was filled with patients immersed in ice. More then 700 patients were admitted with heat stroke, and 150 people died in St. Louis during that heat wave.

Ten days into the scorching heat, Scott Air Force Base sent over a desert team with jet engines to run compressors that generated cold air to be piped into the wards. It was quite a sight to see an enormous tent housing the jet engines in front of the hospital.

There were no private rooms — only large wards with beds on the periphery. On each ward another row of beds was set up in the middle of the room. I can remember going down to City Hospital to see consults and lecture and feeling exactly like I was in a sauna.

All faculty members participated, but particularly yeoman services were rendered by Drs. Bob Heaney, Bill Mootz and Don Kennedy. Everyone who was at City Hospital during that period, including medical students, was invited to a party at Dr. Steve Ayres’ home, who then was chairman of the department. We were given a blue pin with 1980 emblazoned on it. Several weeks later at medicine grand rounds at the LRC, Dr. Ayres asked all of the people from City Hospital to stand amidst thunderous applause.

When I interview candidates for faculty positions I tell them our story. It goes some-thing like this.

Saint Louis University’s School of Medi-cine is the oldest medical school west of the Mississippi, and the department of internal medicine is 100 years old. I have been here for 17 of those years.

When I arrived in 1994, I gathered the University as a whole was experiencing some-thing of a revival under University President Lawrence Biondi, S.J. Since becoming presi-dent in 1987, Fr. Biondi has committed vast University resources to academics, student scholarships, financial aid, faculty recruit-ment, state-of-the-art technology and campus improvement projects.

Thanks to his leadership, SLU has grown from a mostly commuter school that drew primarily only local students into a major national university that attracts students from all 50 states and nearly 80 countries. And Fr. Biondi has transformed a campus that — nearly 25 years ago — was a collection of unrelated buildings interrupted by busy city streets into a lush urban oasis lauded for its beauty.

At the same time, the department of internal medicine was undergoing a revival of its own under the leadership of Dr. Coy Fitch. Beginning in 1988, he recruited a series of young, vigorous division directors who in turn, recruited young, energetic faculty. The department grew substantially during the 1990s and reached a plateau where it has been for the last five years.

Then, I tell those faculty candidates that I believe the department is poised for another cycle of growth. The reasons for this are new leadership in the form of a new dean, Philip O. Alderson, M.D., and my appointment as chair of the department. SLU has commit-ted to making a very substantial investment in the department, and it is my hope that, using these resources, we will be able to again recruit another series of young, vigorous division directors, and they will recruit new clinicians, researchers and teachers. In fact we have named three such vigorous division directors in the last few months (see Vital Signs).

At this turning point, it is important to re-flect on our history and see how far we have come before we look ahead to the tasks and opportunities that lie ahead.

MON

TELE

ONE

remembering the 1980 heat wave

a little comic relief

in graditude

2000's

2000 D. Douglas Miller, M.D. (Bus ’99) , is named chairman of the department.

2001 Saint Louis University Liver Center is established. It becomes the larg-est liver center in Missouri in terms of

research funding, patient visits, clinical trials and hepatologists. It has the most active Hepatitis C practice in the United States.

2006 World renowned hepatologist Adrian M. Di Bisceglie, M.D., is appointed acting chair-man of the department. In 2009 Di Bisceglie is named chair and inaugural holder of the Badeeh A. and Christine V. Bander Chair in Inter-nal Medicine.

2008 The University opens the new Edward A. Doisy Research Center.

The department has grown to:

128 full-time faculty 275 part-time faculty 103 residents 75 fellows

Faculty members serve as attending physi-cians at Saint Louis University Hospital, the Veterans Administration Medical Center, SSM St. Mary’s Health Center and Des Peres Hospital.

The department generated more than $15.5 million in externally funded research in 2010.

MILLER

DI B

ISCE

GLIE

in honor oF Dr. coy FiTch, the physician who helped lead SLU’s department of internal medicine to prominence, the Fitch family has established the Drs. Coy D. and Rachel F. Fitch Endowed Lectureship Fund. Gifts to this fund can be made using the envelope which appears in this magazine.

Between the construction going on outside her office win-dow and the air conditioning unit being installed on the floor above, it can be difficult to hold a conversation with Angela M. Sharkey, M.D. (’86). She doesn’t appear to mind, however, because she’s not in her office much anyway. Since being appointed in November as associate dean for faculty affairs and development in the School of Medicine, Sharkey has been on the move — meeting with faculty about her plans to help them evaluate their career objectives and life goals. Before joining Saint Louis University, Sharkey was on the faculty at Washington University School of Medicine for 18 years. She directed the fetal echocardiography laboratory, and cardiac outreach and fetal program development. Sharkey also gained extensive experience in faculty development program-ming. She served as director of Washington University’s office of faculty development in the department of pediatrics and was co-chair of a program to spotlight women in medicine and science. She is a member of the American Heart Asso-ciation’s committee on mentoring and early career develop-ment, and is a speaker at national meetings on topics including mentorship, teamwork and career paths in academic medicine. Sharkey, who also is a professor of pediatrics, has deep roots on SLU’s campus. Not only did she graduate from the medical school, so did her grandfather, William Brady Sharkey, M.D. (’24), her father, Phillip H. Sharkey, M.D. (’60), and her father-in-law, Joseph J. Lauber, M.D. (’55).

Sharkey started her job at SLU on the same day her father was on campus to celebrate his 50-year class reunion.

GR: How does it feel to be back at the School of Medicine?

AS: Wonderful. It’s really interesting to me that some of the educators who taught me in medical school and during my residency at Cardinal Glennon are still here. Clearly it means that people who come to SLU based on its mission of compassion-ate care, education and research just love it here.

GR: How did you become interested in faculty development?

AS: I oversaw the medical student clerkship program in pediat-rics at Washington University for more than 13 years and found the aspect I enjoyed most was career counseling. I liked helping the students figure out what they wanted to be when they grew

up and what they needed to do in order to reach their targets. At the same time, I noticed that while 70 percent of our trainees in pediatrics were women, there was an absence of women in leadership positions within our department and medical school. I began focusing my passions on helping women faculty put their best foot forward so they could be recognized for the value they brought to the institution and be considered for potential leadership roles. Eventually, I assumed leadership of the faculty development taskforce for the Council on Medical Student Edu-cation in Pediatrics (COMSEP) and oversaw the development of a roadmap for faculty to follow in order to become success-ful leaders. It was through my work within COMSEP that I was able to cultivate my national reputation as an educator with expertise in faculty development. I was promoted to professor and was able to find a leadership role myself.

GR: This is a new position within the School of Medicine. Why is it needed, and what vision do you have for the office?

AS: Through focused efforts in faculty development for clini-cians, clinician educators and researchers, we hope to retain our most valuable resource — our faculty. No matter how success-ful faculty members might be, it’s only natural for them to want opportunities to advance. We will work to give faculty those opportunities in an environment in which they feel supported. We have research faculty, we have individuals who are inter-ested in medical education, and we have physicians interested in medical care, so we will provide a tripartite approach to faculty development. There will be some overlap, but we’ll have specific programs for various faculty members because it’s important to acknowledge and develop faculty needs with regard to the three missions of the medical school.

Specifically, our faculty development efforts will focus on such topics as promotion, mentoring, teamwork and work-life bal-ance. A leadership training program is under development to augment the skills of the future leaders of the Medical Center. The goal is to make the School of Medicine an even better place to work. Allowing our medical faculty to continue to be successful in their careers broadens the reputation of the school throughout the region and country, as well as allows us to con-tinue to provide excellent patient care.

GR: The School of Medicine has a number of faculty who’ve been here for some time and some who are early in their careers. How do you plan to attract and retain productive mid-level physicians?

AS: The way to retain mid-level faculty is to enable them to see a path where they can continue to develop — whether it be in a leadership role as a division director or as chair of an important committee. They have to have ongoing engagement in the University processes. If you’re developing faculty well, they’re going to be recruited away. You have to celebrate that as a success, but it does leave a void for us. So we need mecha-nisms for succession planning that are non-threatening to our current leaders but allow developing faculty to see there’s the potential for them to move up.

GR: Everyone agrees faculty development is important. It’s just finding time to do it. Faculty hired as clinician educators, for example, have aggressive targets for clinical income that interfere with time for professional development. How will your office help these faculty members?

AS: I understand this challenge firsthand. Faculty feel pulled because they need to be clinically productive. That’s why we’ll focus some of our resources on helping faculty use their time wisely and continue to educate in their clinical environments more efficiently. Our former traditions of teaching with a lecture and a PowerPoint presentation are going to have to be modified. The exciting part about that is we get to be innovative. Our office will provide faculty with training on new technolo-gies and formats available to facilitate the transfer of informa-tion to trainees. We need to develop faculty skill in teaching in the outpatient clinic, the One Minute Preceptor model for example. We’ll also provide faculty with efficient frameworks for how they can outline the work that they are doing — whether it be for their educator portfolio or their CV — so when it’s time to come up for promotion, they’re not doing additional work. The work’s been done along the way.

I’m also passionate about the effectiveness of teamwork. Most people think of mentoring as a one-on-one relationship, but uti-lizing a team of peers as your mentors is becoming increasingly important. I’ve had some success with peer mentoring programs in my former institution, which resulted in increased career satis-faction as well as increased academic productivity.

GR: How does the School of Medicine’s commitment to interprofes-sional education fit with your plans?

AS: My plans dovetail beautifully with the interprofessional philosophy. In fact, the University’s commitment to IPE at-tracted me to this office because the platform’s already in place. The University has positioned itself to become a national leader in this new approach to medical education. Health care reforms demand that we work collaboratively, and our faculty develop-ment plans will include ways of implementing IPE programs. IPE also can help alleviate the concerns we addressed earlier about clinical faculty not having enough time to work on their personal development. Emphasizing the importance of the team and bringing together health care professionals so the group — not just the physician — but other members of the health care team can provide patient care in a continuous ef-ficient manner can free the physician for other endeavors. Also, our development efforts will stress amplifying communication by clarifying expectations for what the learners (fellows, resi-dents, students) are going to do. This empowers the learners to augment rather than duplicate the care that’s being provided in the clinical setting. This can go a long way in allowing faculty to reach their clinical targets and provide opportunities for learners. Ultimately, our goal is to have the learners see that a career in academic medicine can be rewarding and fulfilling, so that they, too, will consider a long-term career at SLU.

Grand Rounds 13

Mechanisms for Meeting the MissionNew dean of faculty development strives

to give physicians and researchers a voice

Between the construction going on outside her office win-dow and the air conditioning unit being installed on the floor above, it can be difficult to hold a conversation with Angela M. Sharkey, M.D. (’86). She doesn’t appear to mind, however, because she’s not in her office much anyway. Since being appointed in November as associate dean for faculty affairs and development in the School of Medicine, Sharkey has been on the move — meeting with faculty about her plans to help them evaluate their career objectives and life goals. Before joining Saint Louis University, Sharkey was on the faculty at Washington University School of Medicine for 18 years. She directed the fetal echocardiography laboratory, and cardiac outreach and fetal program development. Sharkey also gained extensive experience in faculty development program-ming. She served as director of Washington University’s office of faculty development in the department of pediatrics and was co-chair of a program to spotlight women in medicine and science. She is a member of the American Heart Asso-ciation’s committee on mentoring and early career develop-ment, and is a speaker at national meetings on topics including mentorship, teamwork and career paths in academic medicine. Sharkey, who also is a professor of pediatrics, has deep roots on SLU’s campus. Not only did she graduate from the medical school, so did her grandfather, William Brady Sharkey, M.D. (’24), her father, Phillip H. Sharkey, M.D. (’60), and her father-in-law, Joseph J. Lauber, M.D. (’55).

Sharkey started her job at SLU on the same day her father was on campus to celebrate his 50-year class reunion.

GR: How does it feel to be back at the School of Medicine?

AS: Wonderful. It’s really interesting to me that some of the educators who taught me in medical school and during my residency at Cardinal Glennon are still here. Clearly it means that people who come to SLU based on its mission of compassion-ate care, education and research just love it here.

GR: How did you become interested in faculty development?

AS: I oversaw the medical student clerkship program in pediat-rics at Washington University for more than 13 years and found the aspect I enjoyed most was career counseling. I liked helping the students figure out what they wanted to be when they grew

up and what they needed to do in order to reach their targets. At the same time, I noticed that while 70 percent of our trainees in pediatrics were women, there was an absence of women in leadership positions within our department and medical school. I began focusing my passions on helping women faculty put their best foot forward so they could be recognized for the value they brought to the institution and be considered for potential leadership roles. Eventually, I assumed leadership of the faculty development taskforce for the Council on Medical Student Edu-cation in Pediatrics (COMSEP) and oversaw the development of a roadmap for faculty to follow in order to become success-ful leaders. It was through my work within COMSEP that I was able to cultivate my national reputation as an educator with expertise in faculty development. I was promoted to professor and was able to find a leadership role myself.

GR: This is a new position within the School of Medicine. Why is it needed, and what vision do you have for the office?

AS: Through focused efforts in faculty development for clini-cians, clinician educators and researchers, we hope to retain our most valuable resource — our faculty. No matter how success-ful faculty members might be, it’s only natural for them to want opportunities to advance. We will work to give faculty those opportunities in an environment in which they feel supported. We have research faculty, we have individuals who are inter-ested in medical education, and we have physicians interested in medical care, so we will provide a tripartite approach to faculty development. There will be some overlap, but we’ll have specific programs for various faculty members because it’s important to acknowledge and develop faculty needs with regard to the three missions of the medical school.

Specifically, our faculty development efforts will focus on such topics as promotion, mentoring, teamwork and work-life bal-ance. A leadership training program is under development to augment the skills of the future leaders of the Medical Center. The goal is to make the School of Medicine an even better place to work. Allowing our medical faculty to continue to be successful in their careers broadens the reputation of the school throughout the region and country, as well as allows us to con-tinue to provide excellent patient care.

GR: The School of Medicine has a number of faculty who’ve been here for some time and some who are early in their careers. How do you plan to attract and retain productive mid-level physicians?

AS: The way to retain mid-level faculty is to enable them to see a path where they can continue to develop — whether it be in a leadership role as a division director or as chair of an important committee. They have to have ongoing engagement in the University processes. If you’re developing faculty well, they’re going to be recruited away. You have to celebrate that as a success, but it does leave a void for us. So we need mecha-nisms for succession planning that are non-threatening to our current leaders but allow developing faculty to see there’s the potential for them to move up.

GR: Everyone agrees faculty development is important. It’s just finding time to do it. Faculty hired as clinician educators, for example, have aggressive targets for clinical income that interfere with time for professional development. How will your office help these faculty members?

AS: I understand this challenge firsthand. Faculty feel pulled because they need to be clinically productive. That’s why we’ll focus some of our resources on helping faculty use their time wisely and continue to educate in their clinical environments more efficiently. Our former traditions of teaching with a lecture and a PowerPoint presentation are going to have to be modified. The exciting part about that is we get to be innovative. Our office will provide faculty with training on new technolo-gies and formats available to facilitate the transfer of informa-tion to trainees. We need to develop faculty skill in teaching in the outpatient clinic, the One Minute Preceptor model for example. We’ll also provide faculty with efficient frameworks for how they can outline the work that they are doing — whether it be for their educator portfolio or their CV — so when it’s time to come up for promotion, they’re not doing additional work. The work’s been done along the way.

I’m also passionate about the effectiveness of teamwork. Most people think of mentoring as a one-on-one relationship, but uti-lizing a team of peers as your mentors is becoming increasingly important. I’ve had some success with peer mentoring programs in my former institution, which resulted in increased career satis-faction as well as increased academic productivity.

GR: How does the School of Medicine’s commitment to interprofes-sional education fit with your plans?

AS: My plans dovetail beautifully with the interprofessional philosophy. In fact, the University’s commitment to IPE at-tracted me to this office because the platform’s already in place. The University has positioned itself to become a national leader in this new approach to medical education. Health care reforms demand that we work collaboratively, and our faculty develop-ment plans will include ways of implementing IPE programs. IPE also can help alleviate the concerns we addressed earlier about clinical faculty not having enough time to work on their personal development. Emphasizing the importance of the team and bringing together health care professionals so the group — not just the physician — but other members of the health care team can provide patient care in a continuous ef-ficient manner can free the physician for other endeavors. Also, our development efforts will stress amplifying communication by clarifying expectations for what the learners (fellows, resi-dents, students) are going to do. This empowers the learners to augment rather than duplicate the care that’s being provided in the clinical setting. This can go a long way in allowing faculty to reach their clinical targets and provide opportunities for learners. Ultimately, our goal is to have the learners see that a career in academic medicine can be rewarding and fulfilling, so that they, too, will consider a long-term career at SLU.

Grand Rounds 13

Mechanisms for Meeting the MissionNew dean of faculty development strives

to give physicians and researchers a voice

As the last person called, Stanley Hoang also took home the cash pot. Every year, each student adds $1 to the pot when his or her name is called. The final student to receive his or her placement letter wins the money. Hoang will specialize in anesthesiology at University of Texas-Galveston.

Friends celebrate their placements at the March 17 ceremony at Busch Stadium Redbirds Club. (l-r)Rosemary Foster will specialize in anesthesiology at Barnes-Jewish Hospital, Patrick Reich will specialize in pediatrics at St. Louis Children’s Hospital, and Kristina Raveendran will specialize in family medicine at Saint Louis University’s family medicine practice in Belleville, Ill.

AneSTHeSioLoGyMelody Anderso St. Lukes-Roosevelt-N.Y.Paul Courtney University of Texas Medical Branch-GalvestonJordan eddington Saint Louis University School of MedicineDena els Rush University Medical Center-Ill.Matthew engel Cleveland Clinic Foundation-OhioRosemary Foster Barnes-Jewish Hospital-Mo.George Gilkey Mayo School of Graduate Medical Education-Minn.Chad Heng University of Southern CaliforniaJessica Hiruma UCLA Medical Center-Calif.Stanley Hoang University of Texas Medical Branch-GalvestonJohn Lee University of Southern Californianicole Marsh Harbor-UCLA Medical Center-Calif.Suraj Parulkar Northwestern McGaw/CMH-Ill.Mark Schmidt Rush University Medical Center-Ill.Michael Sunderbruch Loyola University Medical Center-Ill.Justin Tong Rush University Medical Center-Ill.eleain Tu UCLA Medical Center-Calif.Sanjana Vig St. Lukes-Roosevelt-N.Y.

DeRMAToLoGyKatherine Martin Barnes-Jewish Hospital-Mo.

eMeRGenCy MeDiCineArif Azam University of Texas Medical School-HoustonJohn Cheesebrew Orlando Health-Fla.Anneliese Cuttle Johns Hopkins Hospital-Md.Scott Haight Barnes-Jewish Hospital-Mo.Collin Jackson Michigan State University- KalamazooMichael Kueber Mayo School of Graduate Medical Education-Minn.Theodor Schmidt University of Illinois-St. Francis Medical Center

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As the last person called, Stanley Hoang also took home the cash pot. Every year, each student adds $1 to the pot when his or her name is called. The final student to receive his or her placement letter wins the money. Hoang will specialize in anesthesiology at the University of Texas-Galveston.

AneSTHeSioLoGyMelody Anderson St. Lukes-Roosevelt-N.Y.Paul Courtney University of Texas Medical Branch-GalvestonJordan eddington Saint Louis University School of MedicineDena els Rush University Medical Center-Ill.Matthew engel Cleveland Clinic Foundation-OhioRosemary Foster Barnes-Jewish Hospital-Mo.George Gilkey Mayo School of Graduate Medical Education-Minn.Chad Heng University of Southern CaliforniaJessica Hiruma UCLA Medical Center-Calif.Stanley Hoang University of Texas Medical Branch-GalvestonJohn Lee University of Southern Californianicole Marsh Harbor-UCLA Medical Center-Calif.Suraj Parulkar Northwestern McGaw/CMH-Ill.Mark Schmidt Rush University Medical Center-Ill.Michael Sunderbruch Loyola University Medical Center-Ill.Justin Tong Rush University Medical Center-Ill.eleain Tu UCLA Medical Center-Calif.Sanjana Vig St. Lukes-Roosevelt-N.Y.

DeRMAToLoGyKatherine Martin Barnes-Jewish Hospital-Mo.

eMeRGenCy MeDiCineArif Azam University of Texas Medical School-HoustonJohn Cheesebrew Orlando Health-Fla.Anneliese Cuttle Johns Hopkins Hospital-Md.Scott Haight Barnes-Jewish Hospital-Mo.Collin Jackson Michigan State University- KalamazooMichael Kueber Mayo School of Graduate Medical Education-Minn.Theodor Schmidt University of Illinois-St. Francis Medical Center

Guyve Shalileh University of Arizona/UPHK GME Consortiumivan Shatkin University of South Florida College of Medicine-TampaMichael Treiman Maricopa Medical Center-Ariz.Michael Vulfovich University of Massachusetts Medical SchoolJason West Einstein/Jacobi Medical Center-N.Y.

FAMiLy MeDiCineFrancisco Aleman Christus Spohn Memorial Hospital-TexasMatthew Carpinello Naval Hospital-Camp Pendletonerica Conrad Scott Medical Center-Scott Air Force Base-Ill.Paul Dagenais University of California Davis Medical CenterJaclyn Dorazio Ventura County Medical Center-Calif.Courtney Fahnhorst St. Vincent’s Medical Center-Fla.erin Fisk University Hospitals-Columbia-Mo.Jonathan Gibson University of Maryland Medical CenterCameron Gilmore Saint Louis University School of MedicineMatthew Hoffman University of Minnesota Medical SchoolDenis Kuzelj University of Illinois-Methodist Medical CenterAndrew Lawrence Anderson Area Medical Center-S.C.Lauren Maurer University of Minnesota Medical SchoolAmy McClintock St. Johns Mercy Medical Center-Mo.Kirk o’Donnell Mayo School of Graduate Medical Education-Minn.Adam Pace Mercy Medical Center-Redding-Calif./MFHCRichard Pierson Naval Hospital-JacksonvilleAbby Rardin Contra Costa Regional Medical Center-Calif.Kristina Raveendran Saint Louis University School of MedicineMatthew Schoenherr University of Wisconsin School of Medicine and Public Health

Julie Settle Cox Medical Centers-Mo.Fine Song West Suburban Medical Center-Ill.Mark Stahlschmidt Ventura County Medical Center-Calif.Quoc-Phong Tran New York Medical College St. Joseph’s Medical Center ProgramGretchen Vanden Berg University of Minnesota Medical School

inTeRnAL MeDiCineedris Aman University of California Davis Medical CenterDevon Branvold Jackson Memorial Hospital-Fla.Dmitry Blumenkrants University of Illinois College of Medicine-Chicago UIHAllison Carmichael Scripps Clinic/Green Hospital-Calif.Michael Darley University of Utah Affiliated HospitalsDavid DeWolfe Rhode Island Hospital/Brown UniversityMatthew Hansen University of Colorado School of Medicine-DenverJena Joy Kaiser Permanente-Oakland-Calif. MPHJae-Woo Kim University of Minnesota Medical SchoolJangwon Lee William Beaumont Army Medical CenterDaphne Lo University of Colorado School of Medicine-DenverAndrew Moses University of South Alabama HospitalsGenevieve Moyer Saint Louis University School of MedicineJasjit Mudhar Loyola University Medical Center-Ill.Allen onizuka Kaiser Permanente-Los AngelesAnand Patel University of Michigan Hospitals-Ann ArborBhavesh Patel University of Southern CaliforniaDaniel Pearson Wright Patterson Medical Center Air Force BaseAngad Rai Kaiser Permanente-Los AngelesAbhishek Shah University of California San Diego Medical Center

Sheena Spielberg University of Missouri-Kansas City ProgramsPatrick Stevens Vanderbilt University Medical Center-Tenn.Sahar Taqui University of California San Diego Medical CenterJeremy Timm University of Utah Affiliated Hos-pitalsDong To White Memorial Medical Center ProgramTabitha Townsend Medical University of South CarolinaMargaret Whitcraft St. Johns Mercy Medical Center-Mo.Stephen yau Rush University Medical Center-Ill.

neURoLoGiCAL SURGeRyJonathon Lebovitz Saint Louis University School of MedicineSheri Palejwala University of Arizona Affiliated Hospitalsian White Indiana University School of Medicine

neURoLoGyDavid McCoy University of Oklahoma College of Medicine-Oklahoma CityThong Pham Harbor-UCLA Medical CenterMegan Skorupa Vanderbilt University Medical Center-Tenn.Brian yurgionas University of California San Francisco

oBSTeTRiCS-GyneCoLoGyMelinda Auer Case Western/MetroHealth Medical Center-Ohioeric Behrman Greenville Hospital System/ University of South Carolina School of MedicineKinley Berger Saint Louis University School of MedicineAmy Bilyeu Washington Hospital Center-D.C.Maureen Cho Kaiser Permanente-San FranciscoSara Gorsky Saint Louis University School of MedicineKallie Harrison Saint Louis University School of Medicine

Mary Harrison University of Texas Southwestern Medical School-DallasShirley Hinshaw Medical College of Wisconsin Affiliated HospitalsBronwyn Kenny UVM/Fletcher Allen-VermontChris Kliethermes Saint Louis University School of MedicineMargo Smith National Capital Consortium-USNBrittney Thall University of Colorado School of Medicine-Denver

oPHTHALMoLoGyDavid Dodds Saint Louis University School of Medicineirfan Khan University of Virginia Program-Charlottesvilleneerav Lamba John H. Stoger Hospital of Cook County-ChicagoMansi Patel Drexel University College of MedicineTal Rubenstein Cleveland Clinic Foundation-Cole Eye Institute

oRTHoPAeDiC SURGeRyJudd Allen University of Oklahoma College of Medicine-Oklahoma CityBryce Cunningham University of Tennessee College of Medicine-Chattanooga Travis Junge SAMMC-Ft. Sam Houston Air Force Base-TexasScott Lukens University of Toledo-OhioJohn Miller Loyola University Medical Center-Ill.Michael Pitta Georgetown University Hospital-D.C.Daniel Whiting Mayo School of Graduate Medical Education-Minn.

Benjamin Wilke Mayo School of Graduate Medical Education-Minn.

oToLARynGoLoGyChristopher Britt University of Wisconsin Hospital and ClinicsMatthew Greulich University of Minnesota Medical SchoolJonathan Lusardi University of Chicago Medical CenterPeter McGuire Louisiana State University School of Medicine-New OrleansHetal Patel Hershey Medical Center/Penn State Aaron Robinson University of California Davis Medical Centernicholas Scazitti SAMMC-Lackland Air Force Base-Texasnicholas VanBuren University of Utah Affiliated Hospitals

PATHoLoGyKimberly Janssen University of North Carolina HospitalsKelly Moses University of South Alabama HospitalsAnnie Simpson Emory University Programevan yung University of Southern California

PeDiATRiCSJulie Berg Children’s National Medical Center-D.C.-CNMC Community HealthJonathan Brigham Children’s Hospital-Los AngelesSarah Bryant Saint Louis University School of MedicineDayna Chin University of California Irvine Medical Center-CHOCAma Karikari University of Arkansas-Little Rock

Terence Kothe Saint Louis University School of MedicineKara Kuhn University of California Davis Medical CenterKatherine Magnuson University of Wisconsin Hospital and ClinicsSarah Maufe UCLA Medical CenterMelissa Mavers UCLA Medical CenterChristina Papantonakis Palmetto Health-Richland, S.C.neil Patel Rush University Medical Center-Ill.Robert Petersen Saint Louis University School of Medicineelisa Pincus Saint Louis University School of MedicinePreethi Rangachari Northwestern McGaw/CMH-Ill.Patrick Reich St. Louis Children’s HospitalRegina Rowe University of Texas Southwestern Medical SchoolAbigail Schachter Saint Louis University School of MedicineWhitnee Stuban Oregon Health and Science Uni-versityKrystal Vasoya Children’s Hospital-Oakland, Calif.Jacquelyn Whitney Saint Louis University School of MedicineKatie Wolfe Northwestern McGaw/CMH-Ill.Rebecca young Saint Louis University School of MedicineJacob Wingerter University of Texas Southwestern Medical School

PeDiATRiCS/CHiLD neURoLoGyJan Ludke University of Colorado School of Medicine-DenverCarter Richards Saint Louis University School of Medicineemmanuelle Tiongson Children’s Hospital-Los Angeles

PHySiCAL MeDiCine AnD ReHABiLiTATionUdayan Kulkarni Virginia Commonwealth University Health SystemAdam Schulte Barnes-Jewish Hospital-Mo.

RADiATion-onCoLoGyChristopher Abraham Barnes-Jewish Hospital-Mo.

RADiATion-DiAGnoSTiCemad Allam Saint Louis University School of MedicineMustafa Al-Roubaie North Shore University-Manhasset-N.Y.Michael Ghazarian University of Texas Medical School-HoustonKatia Kaplan-List Rochester General HospitalKurtis Mauer Saint Louis University School of MedicineBrandon Taylor St. Luke’s Medical Center-Wis.Adrian Terry University of Tennessee Methodist HospitalRobert yuen Saint Louis University School of Medicine

SURGeRy-GeneRALJoshua Barnhill Naval Medical Center-San DiegoThomas Heafner SAMMC-Lackland AFB-TexasAmanda Hiler University of California-San FranciscoSamuel Luka George Washington University-D.C.Hoanglong nguyen UIC/Metro Group Hospitals-Ill.nicholas Rottler Saint Louis University School of MedicineAnji Wall Vanderbilt University Medical Center-Tenn.

URoLoGyChristopher Brown University of Arizona Affiliated HospitalsDanny Huynh University Hospitals-Columbia-Mo.McCabe Kenny University of Colorado School of Medicine-DenverJessica Peterson Loyola University Medical Center-Ill.

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Friends celebrate their placements at the March 17 ceremony at Busch Stadium Redbirds Club. (l-r)Rosemary Foster will specialize in anesthesiology at Barnes-Jewish Hospital, Patrick Reich will specialize in pediatrics at St. Louis Children’s Hospital, and Kristina Raveendran will specialize in family medicine at Saint Louis University’s family medicine practice in Belleville, Ill.

16

Poised for Discovery

Grand Rounds 17

G R A N T S at a Glancechristian Lemon, ph.D., assistant professor in the department of pharmacological and physiological science, received a $1.5 million grant from the National Institutes of Health for the project, “Taste and Oral Sensory Processing in the Brain.

patrick M. stuart, ph.D., associate research professor in the department of ophthal-mology, has received a $1.4 million grant from the National Institutes of Health for the project, “Mechanisms of Herpes Simplex Keratitis Amelioration.”

Gul n. shah, ph.D., research professor of internal medicine in the division of endo-crinology, has received a $1.2 million grant from the National Institutes of Health for the project, “Mitochondrial Carbonic Anhydrases and Diabetic Blood Brain Barrier Disruption A2.”

Mark L. Buller, ph.D., professor in the department of molecular microbiology and immunology, has received a $700,000 grant from the National Institutes of Health for the project, “Animal Models of Infectious Disease.”

Donna r. halloran, M.D., M.s.p.h., assistant professor in the department of pediatrics, has received a $651,000 grant from the National Institute of Child Health and Human Development for the project, “Burden of Late-Preterm Births Throughout the First Year of Life.”

Although the three

researchers profiled in this issue of Grand Rounds have been with the School of Medicine only a short time, their

investigations are bringing national attention and National Institutes of Health support to the University.

Hawiger, Baldán and Teague

»

»

16

Poised for Discovery

Grand Rounds 17

examine the effect of miR-33 antagonists on HDL and atherosclerosis, hypothesizing that silencing this microRNA will result in elevated func-tional HDL levels in circula-tion and, consequently, in smaller lesions in the arteries. Additionally, Baldán’s lab is investigating the impact of miR-33 over-expression or silencing on other aspects of cholesterol metabolism, with a special interest in the liver.

Daniel Hawiger, M.D., Ph.D.Assistant Professor | Department of Molecular Biology and ImmunologyJoined SLU in 2010

For the past decade, Daniel Hawiger, M.D., Ph.D., has been unraveling the complex secrets underlying the mal-functions of the immune sys-tem that lead to autoimmune diseases such as multiple sclerosis (MS). His research has implications for many other autoimmune diseases as well, including diabetes and inflammatory bowel disease (IBD).

In autoimmune diseases such as MS, problems arise when the body mounts an overactive immune response against substances and tissues normally present in the body. Under normal conditions, T cells, which are key players in the body’s immune response, are able to discriminate between “self ” cells (those of the body) and “nonself ” cells (foreign invaders) in a process called immunological tolerance.

“When the T cells do not distinguish properly between self antigens and foreign antigens, they start to destroy all cells and tolerance breaks down,” Hawiger said. “This can result in autoimmune diseases. In contrast, exces-sive tolerance could restrain

Academy of Sciences of the United States of America, found that the microRNA miR-33 may be key to controlling HDL cholesterol levels.

Statins, frequently pre-scribed to manage cholesterol levels, work by lowering LDL. Their role in HDL choles-terol metabolism, however, is still obscure. Importantly, HDL has been found to have a protective benefit against cardiovascular disease.

“Atherosclerosis costs lives and takes an enormous toll on our health,” Baldán said. “If the discovery that miR-33 can be used to raise HDL levels leads to better medications, it will have an enormous impact on our ability to treat heart disease.”

The study examined SREBP-2, a key gene that regulates cholesterol metabo-lism and that is induced in patients taking statins, and zeroed in on the microRNA miR-33, which is expressed within SREBP-2. Increas-ing the levels of miR-33 in the liver, scientists discov-ered, resulted in lower HDL cholesterol levels in an animal model; conversely, turning off miR-33, researchers found, had the effect of raising HDL levels.

Paralleling these results, four separate studies reported similar findings, adding to investigators’ hope that better medications may be on the horizon for managing athero-sclerosis. Scientists anticipate that future medications may prove to be more effective than statins alone by not only lowering LDL-cholesterol levels, but also increasing HDL levels

Following the paper’s publication, Baldán secured a $1.8 million grant from the NIH. He plans to continue to

protective immune response against certain types of cancers.”

Hawiger’s research primar-ily focuses on the physi-ological interactions between T cells and dendritic cells — another key element in de-termining the body’s immune response. The main function of dendritic cells is to process antigen material and present it to other cells of the immune system, including T cells. Dendritic cells can also tell T cells which are self and which are foreign antigens, and when to attack.

“We know the interactions between these two cells are critical, but we really don’t fully understand the molecu-lar mechanisms that underlie the process,” he said. “If we discover such mechanisms, we could help restore immune homeostasis in autoimmunity. This would be a huge break-through because we don’t have very good treatments right now for most autoim-mune diseases.”

Hawiger combines cellular immunology approaches with various molecular methods to define tolerance-regulating pathways. Through an in vivo antigen delivery system he de-

vised, Hawiger discovered that in the steady state dendritic cells induce T cell tolerance and prevent autoimmunity. Most recently, he discovered a critical role played by a transcription factor Hopx in T cell tolerance induced by dendritic cells.

Hawiger received his M.D. in 1996 from Vienna Univer-sity School of Medicine and his Ph.D. in 2003 from the Rockefeller University. He continued his research at Yale before joining the SLU School of Medicine last year. His re-search is funded in part by the National Multiple Sclerosis Society.

“I was drawn to this area of research because the regu-lation of immune response during MS is a big enigma. It entails two different types of immune responses — one that happens in the periphery of the body and the other in the brain. It’s very com-plex and interesting from a scientific perspective but also from a personal perspective. MS can strike at any age, but it usually affects people in their prime — in their 30s — so it’s a disease with an enormous social and economic impact on our society.

G R A N T S at a Glancechristian Lemon, ph.D., assistant professor in the department of pharmacological and physiological science, received a $1.5 million grant from the National Institutes of Health for the project, “Taste and Oral Sensory Processing in the Brain.”

patrick M. stuart, ph.D., associate research professor in the department of ophthal-mology, has received a $1.4 million grant from the National Institutes of Health for the project, “Mechanisms of Herpes Simplex Keratitis Amelioration.”

Gul n. shah, ph.D., research professor of internal medicine in the division of endo-crinology, has received a $1.2 million grant from the National Institutes of Health for the project, “Mitochondrial Carbonic Anhydrases and Diabetic Blood Brain Barrier Disruption A2.”

Mark L. Buller, ph.D., professor in the department of molecular microbiology and immunology, has received a $700,000 grant from the National Institutes of Health for the project, “Animal Models of Infectious Disease.”

Donna r. halloran, M.D., M.s.p.h., assistant professor in the department of pediatrics, has received a $651,000 grant from the National Institute of Child Health and Human Development for the project, “Burden of Late-Preterm Births Throughout the First Year of Life.”

Support for Teague’s work is based on the promise of dual T cell receptors. T cells are naturally designed to attack foreign invaders and ig-nore healthy self-tissue. They play a major role in the im-mune system by recognizing and eliminating infected cells, and also cells that become cancerous tumors.

Tumors, however, have the ability to thwart T cells because they resemble normal self-tissues, and as a result T cells don’t mount a strong response. Indeed, one of the factors that determines how aggressive tumors grow is how well they suppress the immune system.

Teague’s research is aimed at helping T cells overcome these immunosuppressive obstacles that impede robust T cell responses to cancer.

Ryan Teague, Ph.D.Assistant Professor | Department of Molecular Microbiology and ImmunologyJoined SLU in 2008

Cancer is difficult to treat because it can fool the im-mune system and circumvent defenses that usually protect people from disease. Ryan Teague, Ph.D., is conducting research aimed at under-standing and bolstering the immune response to tumors by identifying and overcoming obstacles to cancer immuno-therapy.

Teague received $1.2 mil-lion from the NIH’s National Institute of Allergy and Infec-tious Diseases to study im-munotherapy against cancer. Teague also received $200,000 from the Cancer Research Institute in an award given to promising young investigators in cancer immunology.

To do this, Teague is using engineered dual-receptor T cells. While T cells normally recognize only one target, like a virus, dual-receptor T cells can recognize two distinct antigens at once. Thus, when these T cells interact with a tu-mor and become suppressed, they can be reinvigorated by immunization through the second receptor, triggering a much stronger response. This stronger response then turns against the tumor once again.

In another part of Teague’s study, he looks at a second im-munosuppressive mechanism, the process of T cell deletion. Deletion is a natural part of the body’s attempt to avoid autoimmunity by eliminat-ing activated T cells to keep from hurting healthy tissue, but these same mechanisms also are used by cancer cells to evade T cell responses. By

blocking negative signals in the tumor, Teague hopes to encourage T cells to persist and remain active in the tumor environment.

The goal of Teague’s research is to provide insight into how T cell responses to tumors can be enhanced, and ultimately translated into effective immunotherapy for patients with cancer.

Ángel Baldán, Ph.D. Assistant Professor | Department of Biochemistry and Molecular BiologyJoined SLU in 2009

Thanks to a discovery by Ángel Baldán, Ph.D., scientists have identified an important microRNA that may allow us to better control cholesterol levels in blood.

Baldán’s study, which was published in the July 2010 Proceedings of the National

Although the three

researchers profiled in this issue of Grand Rounds have been with the School of Medicine only a short time, their

investigations are bringing national attention and National Institutes of Health support to the University.

Hawiger, Baldán and Teague

»

»

»

Alumni Pulse

Living The Mission:Where There is Hope

Lester R. Sauvage, M.D. (’48), is one of the world’s leading authorities on the subject of synthetic replacements for diseased arteries. In 1962, he became the first surgeon to successfully use vein tissue as a coronary artery substitute when he took a piece of a research animal’s own vein to replace its heart vessel.

The coronary bypass pro-cedure is the most frequently performed heart operation in the world. And while he has used the procedure to save his patients hundreds of times, Sauvage said it is his patients who save him.

“While I was opening their physical hearts, they were opening my spiritual heart,” he said.

Sauvage is a profound believer in the importance of spirituality in healing. In 1959 when he founded The Hope Heart Institute in Seattle (now in Bellevue, Wash.), he wove his beliefs into the cardiac research laboratory’s mission statement. It was his desire that The Hope be dedicated to preventing and treat-ing heart and blood vessel

disease, as well as improving the physical, emotional and spiritual quality of life for all at risk of or affected by cardiovascular disease.

“Optimal health is much more than the mere absence of disease,” said Sauvage, clinical professor of surgery-emeritus at the University of Washington Medical School. “Extending the physical lives of my patients wouldn’t be truly meaningful if the ex-tended years did not include increased happiness. Medical science now recognizes that the body and the spirit inter-act and that a happy spirit can help heal the body and assist in keeping it healthy.”

Before his retirement from clinical practice in 1991, Sau-vage worked 20-hours days, mostly performing surgery or taking care of patients post-op at Providence Medi-cal Center in Seattle, where he served as chairman of the department of surgery and director of surgical education.

Heart surgeon Mark De-domenico, M.D. (‘64) was The Hope’s first cardiac vascular fellow in 1966. He said Lester Sauvage has been his greatest mentor and friend.

“Even if we’d been in sur-gery from 6:30 in the morn-ing until 11:30 at night, he would make sure his patients got all the time they needed from him,” said Dedomenico, who served on The Hope’s board of directors for four decades and is currently CEO of PRO Sports Clubs, the largest sports-medicine club for athletes in the United States. “When I made rounds with him, he always told me to touch the patients and let the patients know we love them. He is tireless and dedicated, and I owe all my successes in medicine, busi-ness and life to him.”

When Sauvage wasn’t with his patients, he was building The Hope into a world-class research facility. The institute’s 24 scientists are dedicated to researching synthetic blood vessel grafts, vascular surgical techniques, and prediction and prevention of thrombotic complications of atherosclerosis, endothelial cell functions, and vascular autografts.

In addition to performing the world’s first experimental use of vein grafts for coro-nary artery bypass, Sauvage and his colleagues devel-oped the healing concept of assisted cellular migration, which formed the basis for the design of the Sauvage line of synthetic blood vessel grafts. He and his researchers designed an operation that shares the abundant blood supply of an arm with the lower limbs of fragile, elderly patients, enabling them to

walk, sleep and avoid amputa-tions.

Sauvage and his team developed a test to measure the tendency of an individ-ual’s blood platelets to form life-threatening clots and drugs to prevent such clots. They also were the first in the world to use only the internal mammary arteries to restore circulation to the entire heart — a procedure much more durable than vein grafts from the legs, which frequently close off after several years.

Although he retired re-cently as medical director of The Hope, Sauvage comes to work almost daily and is writ-ing his fourth lay book about finding health and happiness in life. In Open Your Heart to the Magic of Love, Sauvage describes his childhood in Wapato, Wash., his accep-tance to SLU’s medical school at the age of 17 and the roots of his spirituality.

He writes, “During the first few months of pre-med, I was torn between entering the Jesuit order and becoming a priest or going on toward a career in medicine. I chose medicine because of an underlying conviction that I could do God’s work in this world best as a doctor. Thus, from the beginning, my ori-entation toward medicine was founded on a firm spiritual base.”

Sauvage spends any free time he has with his wife, Mary Ann, their eight children and 29 grandchildren, all of whom live in the Seattle area.

lester and Mary ann sauvage

18 Grand Rounds Saint Louis University School of Medicine

“I was torn between entering the Jesuit Order and becoming a priest or going on toward a career in medicine. I chose medicine because of an underlying conviction that I could do God’s work in this world best as a doctor.”

SAUvAGE

From Your Alumni Association Presidentedward J. o’Brien Jr., M.D. (’67)

As we go to press, the Uni-versity continues the centennial celebration of the Department of Internal Medicine. Stay tuned for events

being held throughout the year, special CME programs (in spring and fall) and cer-emonies recognizing long-time faculty and staff.

Some of you may not be aware of the ongoing repre-sentative alumni organization called the School of Medicine Executive Advisory Board (EAB). The board is com-posed of graduates repre-senting various classes and specialties. Members meet with the dean bi-annually.

Board subcommittees deal with scholarship funding, diversity and alumni outreach. A specific agenda for each meeting includes reports from these committees and the dean’s update of the medical school and campus. We also discuss ideas on various mat-ters and develop projects to advance the medical school’s mission and outreach.

I thank the past and pres-ent EAB members for their time, talent and loyalty.

I’m sure you’re familiar with the annual Alumni Merit Award presented each year at Reunion Weekend. In addi-tion to continuing this award, we are introducing a second annual award for Community Service, which will be pre-sented for the first time dur-ing Reunion Weekend 2011. Although the deadline has passed for nominations for

Reunion Weekend 2011, your nominations for either award in the future are welcome. You can download nomina-tion forms at medschool.slu.edu/alumni or call the Office of Alumni Relations at (314) 977-8335.

As we continue to build on our alumni outreach ef-forts, I'm pleased to report that we have hosted — and will continue to host — meet-ings with graduates practicing in the local medical commu-nity. We also plan to visit with graduates in nearby com-munities to share with them our progress at the School of Medicine. Nationally, we remain encouraged by the many graduates and former residents who have attended our SLU medical receptions

Show your school colorswww.clubcolors.com/slu

Travel with alumniwww.slu.edu/alumni/travel

markyo

urcalen

dar School of Medicine Alumni Events April 28 John H. Gladney, M.D., Diversity Award Reception May 1 Pediatric Academic Societies / Denver Area Reception May 8 Digestive Disease Week / Chicago Area Reception May 19 Pre-Commencement June 20-22 New Resident Orientation July 31 White Coat Ceremony Oct. 27-29 Alumni Reunion Weekend: Celebrating the classes of 2006, 2001, 1996,

1991, 1986, 1981, 1976, 1971, 1966, 1961, 1956, 1951 and earlier.

Continuing Medical Education Programs May 21 Dizziness Diagnosis and Management May 24-25 Summer Geriatric Institute: Building Communities of Care June 4 The 4th Annual Acute Stroke and Cerebrovascular Intervention Conference June 17-18 Advance Cosmetic Breast Surgery Techniques July 22-24 Cosmetic Blepharoplasty and Fundamentals of Face Lift July 25-28 Masters Conference for Advanced Death Investigation Aug. 11-13 The 18th Advanced Techniques in Cervical Spine Decompression

and Stabilization Sept. 10 The 10th Annual Symposium on Gastrointestinal Cancers, Clayton, Mo. Oct. 14-16 Hair Restoration Surgery Techniques Oct. 20-23 Microsurgery Suturing Techniques-Free Tissue Transfer for Major Ablative

Defects of the Heat and Neck

For information on alumni events, please contact the Alumni Relations Office at 314-977-8335 or visit medschool.slu.edu/alumni/.

For information on the CME programs, please call the SLU School of Medicine continuing medical education office at 314-977-7401. See updates and details about Practical Anatomy and Surgical Education Workshop programs at medschool.slu.edu/cme.

o’Brien

Alumni Pulse

Living The Mission:Where There is Hope

Lester R. Sauvage, M.D. (’48), is one of the world’s leading authorities on the subject of synthetic replacements for diseased arteries. In 1962, he became the first surgeon to successfully use vein tissue as a coronary artery substitute when he took a piece of a research animal’s own vein to replace its heart vessel.

The coronary bypass pro-cedure is the most frequently performed heart operation in the world. And while he has used the procedure to save his patients hundreds of times, Sauvage said it is his patients who save him.

“While I was opening their physical hearts, they were opening my spiritual heart,” he said.

Sauvage is a profound believer in the importance of spirituality in healing. In 1959 when he founded The Hope Heart Institute in Seattle (now in Bellevue, Wash.), he wove his beliefs into the cardiac research laboratory’s mission statement. It was his desire that The Hope be dedicated to preventing and treat-ing heart and blood vessel

disease, as well as improving the physical, emotional and spiritual quality of life for all at risk of or affected by cardiovascular disease.

“Optimal health is much more than the mere absence of disease,” said Sauvage, clinical professor of surgery-emeritus at the University of Washington Medical School. “Extending the physical lives of my patients wouldn’t be truly meaningful if the ex-tended years did not include increased happiness. Medical science now recognizes that the body and the spirit inter-act and that a happy spirit can help heal the body and assist in keeping it healthy.”

Before his retirement from clinical practice in 1991, Sau-vage worked 20-hours days, mostly performing surgery or taking care of patients post-op at Providence Medi-cal Center in Seattle, where he served as chairman of the department of surgery and director of surgical education.

Heart surgeon Mark De-domenico, M.D. (‘64) was The Hope’s first cardiac vascular fellow in 1966. He said Lester Sauvage has been his greatest mentor and friend.

“Even if we’d been in sur-gery from 6:30 in the morn-ing until 11:30 at night, he would make sure his patients got all the time they needed from him,” said Dedomenico, who served on The Hope’s board of directors for four decades and is currently CEO of PRO Sports Clubs, the largest sports-medicine club for athletes in the United States. “When I made rounds with him, he always told me to touch the patients and let the patients know we love them. He is tireless and dedicated, and I owe all my successes in medicine, busi-ness and life to him.”

When Sauvage wasn’t with his patients, he was building The Hope into a world-class research facility. The institute’s 24 scientists are dedicated to researching synthetic blood vessel grafts, vascular surgical techniques, and prediction and prevention of thrombotic complications of atherosclerosis, endothelial cell functions, and vascular autografts.

In addition to performing the world’s first experimental use of vein grafts for coro-nary artery bypass, Sauvage and his colleagues devel-oped the healing concept of assisted cellular migration, which formed the basis for the design of the Sauvage line of synthetic blood vessel grafts. He and his researchers designed an operation that shares the abundant blood supply of an arm with the lower limbs of fragile, elderly patients, enabling them to

walk, sleep and avoid amputa-tions.

Sauvage and his team developed a test to measure the tendency of an individ-ual’s blood platelets to form life-threatening clots and drugs to prevent such clots. They also were the first in the world to use only the internal mammary arteries to restore circulation to the entire heart — a procedure much more durable than vein grafts from the legs, which frequently close off after several years.

Although he retired re-cently as medical director of The Hope, Sauvage comes to work almost daily and is writ-ing his fourth lay book about finding health and happiness in life. In Open Your Heart to the Magic of Love, Sauvage describes his childhood in Wapato, Wash., his accep-tance to SLU’s medical school at the age of 17 and the roots of his spirituality.

He writes, “During the first few months of pre-med, I was torn between entering the Jesuit order and becoming a priest or going on toward a career in medicine. I chose medicine because of an underlying conviction that I could do God’s work in this world best as a doctor. Thus, from the beginning, my ori-entation toward medicine was founded on a firm spiritual base.”

Sauvage spends any free time he has with his wife, Mary Ann, their eight children and 29 grandchildren, all of whom live in the Seattle area.

lester and Mary ann sauvage

18 Grand Rounds Saint Louis University School of Medicine

“I was torn between entering the Jesuit Order and becoming a priest or going on toward a career in medicine. I chose medicine because of an underlying conviction that I could do God’s work in this world best as a doctor.”

SAUvAGE

From Your Alumni Association Presidentedward J. o’Brien Jr., M.D. (’67)

As we go to press, the Uni-versity continues the centennial celebration of the Department of Internal Medicine. Stay tuned for events

being held throughout the year, special CME programs (in spring and fall) and cer-emonies recognizing long-time faculty and staff.

Some of you may not be aware of the ongoing repre-sentative alumni organization called the School of Medicine Executive Advisory Board (EAB). The board is com-posed of graduates repre-senting various classes and specialties. Members meet with the dean bi-annually.

Board subcommittees deal with scholarship funding, diversity and alumni outreach. A specific agenda for each meeting includes reports from these committees and the dean’s update of the medical school and campus. We also discuss ideas on various mat-ters and develop projects to advance the medical school’s mission and outreach.

I thank the past and pres-ent EAB members for their time, talent and loyalty.

I’m sure you’re familiar with the annual Alumni Merit Award presented each year at Reunion Weekend. In addi-tion to continuing this award, we are introducing a second annual award for Community Service, which will be pre-sented for the first time dur-ing Reunion Weekend 2011. Although the deadline has passed for nominations for

Reunion Weekend 2011, your nominations for either award in the future are welcome. You can download nomina-tion forms at medschool.slu.edu/alumni or call the Office of Alumni Relations at (314) 977-8335.

As we continue to build on our alumni outreach ef-forts, I'm pleased to report that we have hosted — and will continue to host — meet-ings with graduates practicing in the local medical commu-nity. We also plan to visit with graduates in nearby com-munities to share with them our progress at the School of Medicine. Nationally, we remain encouraged by the many graduates and former residents who have attended our SLU medical receptions

that are held in conjunction with major specialty meetings. Please refer to the calendar of events located in this section of Grand Rounds, or visit the alumni website to learn about upcoming receptions. We hope you will join us.

As always, the electronic outreach continues. Keep up with Dialogue with the Dean and the monthly Medical Alumni e-bulletin.

Alumni Executive Advisory Board

President: Edward J. O’Brien Jr., M.D. (’67) St. Louis

Immediate Past-President: Thomas J. Olsen, M.D. (’79) St. Louis

Members:

Mary Agne, M.D. (’88) Belleville

Robert J. Blaskiewicz, M.D. (’75) St. Louis

Mary E. Case, M.D. (’69) St. Louis.

Thomas J. Geller, M.D. (’80) St. Louis

Marilyn Maxwell, M.D. (’81) St. Louis

Duane H. Moore, M.D. (’02) St. Louis

Sheryl S. Ream, M.D. (’86) St. Louis

Thomas A. Schneider, M.D. (’58) Saint Charles

Keith M. Starke, M.D. (’81) St. Louis

Dana P. Valencia, M.D. (Res. ’02) St. Louis

Catherine M. Wittgen, M.D. (’89) St. Louis

Show your school colorswww.clubcolors.com/slu

Travel with alumniwww.slu.edu/alumni/travel

markyo

urcalen

dar School of Medicine Alumni Events April 28 John H. Gladney, M.D., Diversity Award Reception May 1 Pediatric Academic Societies / Denver Area Reception May 8 Digestive Disease Week / Chicago Area Reception May 19 Pre-Commencement June 20-22 New Resident Orientation July 31 White Coat Ceremony Oct. 27-29 Alumni Reunion Weekend: Celebrating the classes of 2006, 2001, 1996,

1991, 1986, 1981, 1976, 1971, 1966, 1961, 1956, 1951 and earlier.

Continuing Medical Education Programs May 21 Dizziness Diagnosis and Management May 24-25 Summer Geriatric Institute: Building Communities of Care June 4 The 4th Annual Acute Stroke and Cerebrovascular Intervention Conference June 17-18 Advance Cosmetic Breast Surgery Techniques July 22-24 Cosmetic Blepharoplasty and Fundamentals of Face Lift July 25-28 Masters Conference for Advanced Death Investigation Aug. 11-13 The 18th Advanced Techniques in Cervical Spine Decompression

and Stabilization Sept. 10 The 10th Annual Symposium on Gastrointestinal Cancers, Clayton, Mo. Oct. 14-16 Hair Restoration Surgery Techniques Oct. 20-23 Microsurgery Suturing Techniques-Free Tissue Transfer for Major Ablative

Defects of the Heat and Neck

For information on alumni events, please contact the Alumni Relations Office at 314-977-8335 or visit medschool.slu.edu/alumni/.

For information on the CME programs, please call the SLU School of Medicine continuing medical education office at 314-977-7401. See updates and details about Practical Anatomy and Surgical Education Workshop programs at medschool.slu.edu/cme.

o’Brien

Bussmann

luisiri

left | Members of the Class of ’85 celebrate their 25-year reunion with the Rev. James Tobin, S.J.

Members of the Class of ’60 take a break from celebrating

their 50 year reunion to pose for a photo in DuBourg Hall.

World renowned pediatric oncologist, Jeffrey Lipton, M.D. (’75), received the 2010 Alumni Merit Award during Reunion Weekend in October

“Dr. Lipton exemplifies the Jesuit ideal of men and women for others,” said Philip O. Alderson, M.D., dean of the School of Medicine. “He has dedicated his life to the care of critically ill children and the discovery of cures for the diseases affecting them.”

After graduating from the School of Medicine, Lipton completed his postdoctoral training and research fellowship in pediatric hematology/oncology at Children’s Hospital Medi-cal Center in Boston. He completed his research fellowship in pediatrics at Harvard Medical School.

Lipton has remained in academic medicine, teaching medical students, fellows and residents. He holds academic appointments as professor of pediatrics and molecular medicine at Hofstra University School of Medicine in New York and in the Elmezzi Graduate School of Molecular Medicine at Hofstra.

His current hospital appointments include serving as direc-tor of hematology-oncology and stem cell transplantation at Schneider Children’s Hospital in the North Shore/Long Island Jewish Health System, on Long Island, N.Y.

The author of more than 200 peer-reviewed articles, ab-stracts and book chapters, Lipton has been recognized with several awards throughout his distinguished career, including awards presented by family support groups such as the Jeffrey Modell Foundation Lifetime Achievement Award in 1992 and the Daniella Maria Arturi Foundation Diamond Blackfan Anemia Pioneer Award in 2004.

Alumni Reunion Weekend 2010

lipton

Saint Louis University School of Medicine Grand Rounds 20

shields

McBride

In MemoriamDonald W. Bussmann, M.D., 1920-2011Donald W. Bussmann, M.D., a cardiologist and medical school administrator from 1965 to 1980, died in January at the age of 90.

Dr. Bussmann joined the School of Medicine as a volunteer member of the cardiology faculty in 1951, and became a full-time faculty member in 1955. An associate professor of inter-nal medicine, Dr. Bussmann helped to found the division of cardiology at SLU.

He special-ized in the study of heart sounds and murmurs, and educated generations of medical

students and residents.In 1962, Dr. Bussmann

began serving on the school’s admissions committee.

Dr. Bussmann was chair-man of the committee on admissions from 1964 to 1980. He was assistant dean for student affairs from 1965 to 1972, associate dean for admissions and student affairs from 1972 to 1975 and associate dean for ad-missions from 1975 to 1980.

Upon his retirement, members of the medi-cal school class of 1983 presented Dr. Bussmann with a special citation at commencement, calling him “the venerable gatekeeper” of SLU School of Medicine.

Atchawee Luisiri, M.D. 1949-2011Atchawee Luisiri, M.D., professor of radiology died in February.

Born in Bangkok, Thai-land, Dr. Luisiri helped sick children in St. Louis for the last 34 years. She was board certified in pediatric radiol-ogy and held a secondary

appointment as assistant professor in the department of pediatrics and adolescent medicine. She also was direc-

tor of pediatric radiology at Cardinal Glennon Children’s Medical Center.

Michael Wolverson, M.D., chair of the department of radiology at SLU, noted Dr. Luisiri’s skill with patients and students as well as her dedica-tion to her job.

“Dr. Luisiri was a very dedicated pediatric radiologist, well-respected by the entire community. Her passing is truly a very sad loss.”

Dr. Luisiri wrote nu-merous book chapters and papers advancing the field of medical imaging and improv-ing doctors’ ability to use imaging equipment, includ-ing ultrasound, CT and MRI. Her work covered many areas from spina bifida to radiology of child abuse.

Lawrence R. McBride, M.D., 1949-2010Lawrence R. McBride, M.D. (’75), former professor of surgery, died in November at the age of 61.

Dr. McBride spent nearly 30 years at SLU as a medical student, resident, cardiotho-racic fellow and professor of surgery. He received the endowed Tenet Chair of Cardiovascular Surgery and directed the heart and lung transplant program at SLU Hospital.

Dr. McBride was a board certified cardiothoracic surgeon whose expertise in-cluded heart and lung trans-

Zimny

Zuckner

plantation, mechanical circula-tory support, the surgical treatment of advanced cardiac disease, valvular heart disease and surgical problems of the aorta including aneurysms and dissections.

“An extraordinarily tal-ented surgeon, Dr. McBride was the sort of surgeon other surgeons would seek out to operate on them or their loved ones,” said Robert G. Johnson, M.D., C. Rollins Hanlon Professor and chair of the department of surgery. “Few could equal his atten-tiveness to the finest points of an operation.”

In 2000, Dr. McBride left SLU and joined the Mayo Clinic in Jacksonville, Fla., where he was chairman of the division of

cardiothoracic surgery. Most recently, Dr. McBride joined the Florida Hospital Transplant Center, where he helped de-velop the first heart transplant program in central Florida.

John B. Shields, M.D., 1931-2010John B. Shields, M.D. (’57), a clinical professor of radiology and former department chair at the School of Medicine, died in December at the age of 79.

Dr. Shields had been a member of the SLU family for 57 years. Origi-nally, Dr. Shields trained at SLU to be a cardio-

thoracic surgeon but changed his specialty to radiology when he was diagnosed with multiple sclerosis.

Dr. Shields joined the radiology department as an instructor in 1978, after com-pleting his resident training in radiology at Saint Louis Uni-

versity Hospital. He served as chairman of the department of radiology from 1978 to 1994, and subsequently was a professor in the department.

Dr. Shields was director of the radiology training pro-gram from 1978 to 1994 and from 2001 to 2004.

“Passionate about teach-ing, Dr. Shields was both the toughest professor and the professor who taught students most,” said Edward J. O’Brien Jr., M.D. (’67), adjunct professor of radiol-ogy and the first resident he trained.

“Everybody remembers Dr. Shields and learned a lot from him. He was a discipli-narian, humble but proud,” O’Brien said.

George H. Zimny, Ph.D. 1926-2011George H. Zimny, Ph.D., pro-fessor emeritus of psychology, died in March at the age of 85.

Dr. Zimny joined the SLU faculty as an associate professor of psychology in the department of psychiatry in 1964. He served as a full professor from 1967 to 1997, when he retired with emeritus status.

During his three decades at SLU, Dr. Zimny published nearly 40 papers and a text-book, Method in Experimental Psychology. He was known for developing the Medical Specialty Preference Inventory tool, an assessment still used today that measures medical students’ interest in various specialties to determine their focus in residency.

Dr. Zimny also served as chief of the section of human behavior from 1967 to 1974 at SLU.

George Grossberg, M.D., professor of psychiatry, called him a “true mentor” - some-one known throughout the department for helping young

faculty members and students with their research aspirations.

“He was a true gentleman who was a first-rate research-

er,” Grossberg said. “He dedicated his career to helping young researchers like me at the time so that we

could get our research off the ground.”

Jack Zuckner, M.D., 1922-2011Jack Zuckner, M.D. (’47), a former professor and director of rheumatology, died in March at the age of 88.

A well-known leader in the field of rheumatology, Dr. Zuckner was the first rheuma-tologist in the St. Louis area. He joined the School of Medicine in 1952 and served as director of the division of rheumatology from 1955-1983.

In 1963, Dr. Zuckner developed the first pediatric arthritis clinic in Missouri at SSM Cardinal Glennon Children’s Medical Center. He also founded SLU’s Arthritis Clinical and Research Center, one of the first local clinics to provide specialized care for rheumatic diseases.

Dr. Zuckner was the first person to become a Master with the American College of Rheumatology in the state of Missouri, and he held numerous leadership roles in professional organizations.

Though Dr. Zuckner retired from SLU in 1983, he maintained a private practice until 1995 and continued to

participate in division confer-ences up until a few years ago.

Bertrand Coughlin, M.D. (’31)Max Starkloff, M.D. (’31)Chester Mellies, M.D. (’33)John Donovan, M.D. (’35)Francis Morris, M.D. (’38)William Knaus, M.D. (’39)Flavius Pernoud Jr., M.D. (’39)William De Fries, M.D. (’40)Stanley Ciapciak, M.D. (’44)Edward Baker, M.D. (’45)Milton Baker, M.D. (’45)George Corti, M.D. (’45)Eugene Brugge, M.D. (’46)James Green, M.D. (’46)Homer Schroeder, M.D. (’46)Philip Doisy, M.D. (’47)Kenneth Michael, M.D. (’47)Glenn West, M.D. (’47)Pablo Ayub, M.D. (’48)Robert Clark, M.D. (’48)Thomas Maher, M.D. (’48)David Cox, M.D. (’49)John Riley, M.D. (’49)Raymond Healy, M.D. (’51)James Kelly, M.D. (’51)Peter Boudoures, M.D. (’52)Sung Hsia, M.D. (’52)Frank Ritter, M.D. (’53)Owen Kwong, M.D. (’54)Robert Love, M.D. (’54)Wallace Pike, M.D. (’54)Shale Rifkin, M.D. (’54)James Allen, M.D. (’55)George Hungerman, M.D. (’55)Angelo Milano, M.D. (’55)William Thorpe, M.D. (’55)Lucien Wright, M.D. (’55)Thomas Way, M.D. (’56) Walter H. Oppenheim, M.D. (’59)Michael Daiuto, M.D. (’60)James Mack, M.D. (’61)Albert Sheff, M.D. (’62)Paul Langlois, M.D. (’63)John Brockley, M.D. (’66)Bernard Podurgiel, M.D. (’67)Edward Kanda, M.D. (’71)Francis Drew, M.D. (’72)Robert Yowell, M.D. (’81)Gregory Mantych, M.D. (’82)

Grand Rounds apologizes to Kathleen Barcia, M.D. (’89), whom we mistakenly listed as deceased in the fall 2010 issue. We are happy to report that Dr. Barcia is alive and well and practicing pediatrics at the Health and Wellness Center of Louisa, a federally qualified community health center in Virginia.

“I want to thank SLU for its past

efforts on my behalf and to support

the education of new generations

of physicians.”

Giving really does change lives.Though the amounts and the reasons may vary, there’s one thing all gifts have in common: Together they make a world of difference to Saint Louis University.

Make your gift by using the envelope enclosed in this issue of Grand Rounds or online by visiting giving.slu.edu.

If you’ve already made a gift to SLU, thank you.

Please visit giving.slu.edu/igive and tell us your reason for giving.

ThoMaS E. REh, M.d. (’69)RadIoLoGIST

SSM ST. MaRy’S hEaLTh CEnTER

One N. Grand Blvd., SON 539

St. Louis, MO 63103

Address Service Requested

Non-Profit Org.U.S. Postage

PAiDSt. Louis, MOPermit No. 134

Giving really does change lives.Though the amounts and the reasons may vary, there’s one thing all gifts have in common: Together they make a world of difference to Saint Louis University.

Make your gift by using the envelope enclosed in this issue of Grand Rounds or online by visiting giving.slu.edu.

If you’ve already made a gift to SLU, thank you.

Please visit giving.slu.edu/igive and tell us your reason for giving.

ThoMaS E. REh, M.d. (’69)RadIoLoGIST

SSM ST. MaRy’S hEaLTh CEnTER

One N. Grand Blvd., SON 539

St. Louis, MO 63103

Address Service Requested

Non-Profit Org.U.S. Postage

PAiDSt. Louis, MOPermit No. 134