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Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk- Related Brain Function and Psychiatric Disorders Janine Arloth, Ryan Bogdan, Peter Weber, Goar Frishman, Andreas Menke, Klaus V. Wagner, Georgia Balsevich, Mathias V. Schmidt, Nazanin Karbalai, Darina Czamara, Andre Altmann, Dietrich Trümbach, Wolfgang Wurst, Divya Mehta, Manfred Uhr, Torsten Klengel, Angelika Erhardt, Caitlin E. Carey, Emily Drabant Conley Stephan Ripke, Naomi R. Wray, Cathryn M. Lewis, Steven P. Hamilton, Myrna M. Weissman, Gerome Breen, Enda M. Byrne, Douglas H.R. Blackwood, Dorret I. Boomsma, Sven Cichon, Andrew C. Heath, Florian Holsboer, Susanne Lucae, Pamela A.F. Madden, Nicholas G. Martin, Peter McGuffin, Pierandrea Muglia, Markus M. Noethen, Brenda P. Penninx, Michele L. Pergadia, James B. Potash, Marcella Rietschel, Danyu Lin, Bertram Müller-Myhsok, Jianxin Shi, Stacy Steinberg, Hans J. Grabe, Paul Lichtenstein, Patrik Magnusson, Roy H. Perlis, Martin Preisig, Jordan W. Smoller, Kari Stefansson, Rudolf Uher, Zoltan Kutalik, Katherine E. Tansey, Alexander Teumer, Alexander Viktorin, Michael R. Barnes, Thomas Bettecken, Elisabeth B. Binder, René Breuer, Victor M. Castro, Susanne E. Churchill, William H. Coryell, Nick Craddock, Ian W. Craig, Darina Czamara, Eco J. De Geus, Franziska Degenhardt, Anne E. Farmer, Maurizio Fava, Josef Frank, Vivian S. Gainer, Patience J. Gallagher, Scott D. Gordon, Sergey Goryachev, Magdalena Gross, Michel Guipponi, Anjali K. Henders, Stefan Herms, Ian B. Hickie, Susanne Hoefels, Witte Hoogendijk, Jouke Jan Hottenga, Dan V. Iosifescu, Marcus Ising, Ian Jones, Lisa Jones, Tzeng Jung-Ying, James A. Knowles, Isaac S. Kohane, Martin A. Kohli, Ania Korszun, Mikael Landen, William B. Lawson, Glyn Lewis, Donald MacIntyre, Wolfgang Maier, Manuel Mattheisen, Patrick J. McGrath, Andrew McIntosh, Alan McLean, Christel M. Middeldorp, Lefkos Middleton, Grant M. Montgomery, Shawn N. Murphy, Matthias Nauck, Willem A. Nolen, Dale R. Nyholt, Michael O’Donovan, Högni Oskarsson, Nancy Pedersen, William A. Scheftner, Andrea Schulz, Thomas G. Schulze, Stanley I. Shyn, Engilbert Sigurdsson, Susan L. Slager, Johannes H. Smit, Hreinn Stefansson, Michael Steffens, Thorgeir Thorgeirsson, Federica Tozzi, Jens Treutlein, Manfred Uhr, Edwin J.C.G. van den Oord, Gerard Van Grootheest, Henry Völzke, Jeffrey B. Weilburg, Gonneke Willemsen, Frans G. Zitman, Benjamin Neale, Mark Daly, Douglas F. Levinson, Patrick F. Sullivan, Andreas Ruepp, Bertram Müller-Myhsok, Ahmad R. Hariri, Elisabeth B. Binder Janine Arloth, Ryan Bogdan, Peter Weber, Goar Frishman, Andreas Menke, Klaus V. Wagner, Georgia Balsevich, Mathias V. Schmidt, Nazanin Karbalai, Darina Czamara, Andre Altmann, Dietrich Trümbach, Wolfgang Wurst, Divya Mehta, Manfred Uhr, Torsten Klengel, Angelika Erhardt, Caitlin E. Carey, Emily Drabant Conley Stephan Ripke, Naomi R. Wray, Cathryn M. Lewis, Steven P. Hamilton, Myrna M. Weissman, Gerome Breen, Enda M. Byrne, Douglas H.R. Blackwood, Dorret I. Boomsma, Sven Cichon, Andrew C. Heath, Florian Holsboer, Susanne Lucae, Pamela A.F. Madden, Nicholas G. Martin, Peter McGuffin, Pierandrea Muglia, Markus M. Noethen, Brenda P. Penninx, Michele L. Pergadia, James B. Potash, Marcella Rietschel, Danyu Lin, Bertram Müller-Myhsok, Jianxin Shi, Stacy Steinberg, Hans J. Grabe, Paul Lichtenstein, Patrik Magnusson, Roy H. Perlis, Martin Preisig, Jordan W. Smoller, Kari Stefansson, Rudolf Uher, Zoltan Kutalik, Katherine E. Tansey, Alexander Teumer, Alexander Viktorin, Michael R. Barnes, Thomas Bettecken, Elisabeth B. Binder, René Breuer, Victor M. Castro, Susanne E. Churchill, William H. Coryell, Nick Craddock, Ian W. Craig, Darina Czamara, Eco J. De Geus, Franziska Degenhardt, Anne E. Farmer, Maurizio Fava, Josef Copyright © 2015 The Authors Terms and Conditions

Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk- Related Brain Function and Psychiatric Disorders Janine Arloth, Ryan

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Page 1: Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk- Related Brain Function and Psychiatric Disorders Janine Arloth, Ryan

Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders 

Janine Arloth, Ryan Bogdan, Peter Weber, Goar Frishman, Andreas Menke, Klaus V. Wagner, Georgia Balsevich, Mathias V. Schmidt, Nazanin Karbalai, Darina Czamara, Andre Altmann, Dietrich Trümbach, Wolfgang Wurst, Divya Mehta, Manfred Uhr, Torsten Klengel,

Angelika Erhardt, Caitlin E. Carey, Emily Drabant Conley Stephan Ripke, Naomi R. Wray, Cathryn M. Lewis, Steven P. Hamilton, Myrna M. Weissman, Gerome Breen, Enda M. Byrne, Douglas H.R. Blackwood, Dorret I. Boomsma, Sven Cichon, Andrew C. Heath, Florian Holsboer, Susanne Lucae, Pamela A.F. Madden, Nicholas G. Martin, Peter McGuffin, Pierandrea Muglia, Markus M. Noethen, Brenda P. Penninx, Michele L. Pergadia, James B. Potash, Marcella Rietschel, Danyu Lin, Bertram Müller-Myhsok, Jianxin Shi, Stacy

Steinberg, Hans J. Grabe, Paul Lichtenstein, Patrik Magnusson, Roy H. Perlis, Martin Preisig, Jordan W. Smoller, Kari Stefansson, Rudolf Uher, Zoltan Kutalik, Katherine E. Tansey, Alexander Teumer, Alexander Viktorin, Michael R. Barnes, Thomas Bettecken,

Elisabeth B. Binder, René Breuer, Victor M. Castro, Susanne E. Churchill, William H. Coryell, Nick Craddock, Ian W. Craig, Darina Czamara, Eco J. De Geus, Franziska Degenhardt, Anne E. Farmer, Maurizio Fava, Josef Frank, Vivian S. Gainer, Patience J.

Gallagher, Scott D. Gordon, Sergey Goryachev, Magdalena Gross, Michel Guipponi, Anjali K. Henders, Stefan Herms, Ian B. Hickie, Susanne Hoefels, Witte Hoogendijk, Jouke Jan Hottenga, Dan V. Iosifescu, Marcus Ising, Ian Jones, Lisa Jones, Tzeng Jung-Ying,

James A. Knowles, Isaac S. Kohane, Martin A. Kohli, Ania Korszun, Mikael Landen, William B. Lawson, Glyn Lewis, Donald MacIntyre, Wolfgang Maier, Manuel Mattheisen, Patrick J. McGrath, Andrew McIntosh, Alan McLean, Christel M. Middeldorp, Lefkos Middleton, Grant M. Montgomery, Shawn N. Murphy, Matthias Nauck, Willem A. Nolen, Dale R. Nyholt, Michael O’Donovan, Högni Oskarsson, Nancy Pedersen, William A. Scheftner, Andrea Schulz, Thomas G. Schulze, Stanley I. Shyn, Engilbert Sigurdsson, Susan L. Slager,

Johannes H. Smit, Hreinn Stefansson, Michael Steffens, Thorgeir Thorgeirsson, Federica Tozzi, Jens Treutlein, Manfred Uhr, Edwin J.C.G. van den Oord, Gerard Van Grootheest, Henry Völzke, Jeffrey B. Weilburg, Gonneke Willemsen, Frans G. Zitman, Benjamin Neale, Mark Daly, Douglas F. Levinson, Patrick F. Sullivan, Andreas Ruepp, Bertram Müller-Myhsok, Ahmad R. Hariri,

Elisabeth B. Binder Janine Arloth, Ryan Bogdan, Peter Weber, Goar Frishman, Andreas Menke, Klaus V. Wagner, Georgia Balsevich, Mathias V. Schmidt, Nazanin Karbalai, Darina Czamara, Andre Altmann, Dietrich Trümbach, Wolfgang Wurst, Divya Mehta, Manfred Uhr, Torsten Klengel, Angelika Erhardt, Caitlin E. Carey, Emily Drabant Conley Stephan Ripke, Naomi R. Wray, Cathryn M. Lewis,

Steven P. Hamilton, Myrna M. Weissman, Gerome Breen, Enda M. Byrne, Douglas H.R. Blackwood, Dorret I. Boomsma, Sven Cichon, Andrew C. Heath, Florian Holsboer, Susanne Lucae, Pamela A.F. Madden, Nicholas G. Martin, Peter McGuffin, Pierandrea Muglia,

Markus M. Noethen, Brenda P. Penninx, Michele L. Pergadia, James B. Potash, Marcella Rietschel, Danyu Lin, Bertram Müller-Myhsok, Jianxin Shi, Stacy Steinberg, Hans J. Grabe, Paul Lichtenstein, Patrik Magnusson, Roy H. Perlis, Martin Preisig, Jordan W. Smoller,

Kari Stefansson, Rudolf Uher, Zoltan Kutalik, Katherine E. Tansey, Alexander Teumer, Alexander Viktorin, Michael R. Barnes, Thomas Bettecken, Elisabeth B. Binder, René Breuer, Victor M. Castro, Susanne E. Churchill, William H. Coryell, Nick Craddock, Ian W. Craig, Darina Czamara, Eco J. De Geus, Franziska Degenhardt, Anne E. Farmer, Maurizio Fava, Josef Frank, Vivian S. Gainer, Patience J. Gallagher, Scott D. Gordon, Sergey Goryachev, Magdalena Gross, Michel Guipponi, Anjali K. Henders, Stefan Herms, Ian B. Hickie, Susanne Hoefels, Witte Hoogendijk, Jouke Jan Hottenga, Dan V. Iosifescu, Marcus Ising, Ian Jones, Lisa Jones, Tzeng Jung-Ying,

James A. Knowles, Isaac S. Kohane, Martin A. Kohli, Ania Korszun, Mikael Landen, William B. Lawson, Glyn Lewis, Donald MacIntyre, Wolfgang Maier, Manuel Mattheisen, Patrick J. McGrath, Andrew McIntosh, Alan McLean, Christel M. Middeldorp, Lefkos Middleton, Grant M. Montgomery, Shawn N. Murphy, Matthias Nauck, Willem A. Nolen, Dale R. Nyholt, Michael O’Donovan, Högni Oskarsson, Nancy Pedersen, William A. Scheftner, Andrea Schulz, Thomas G. Schulze, Stanley I. Shyn, Engilbert Sigurdsson, Susan L. Slager,

Johannes H. Smit, Hreinn Stefansson, Michael Steffens, Thorgeir Thorgeirsson, Federica Tozzi, Jens Treutlein, Manfred Uhr, Edwin J.C.G. van den Oord, Gerard Van Grootheest, Henry Völzke, Jeffrey B. Weilburg, Gonneke Willemsen, Frans G. Zitman, Benjamin Neale, Mark Daly, Douglas F. Levinson, Patrick F. Sullivan, Andreas Ruepp, Bertram Müller-Myhsok, Ahmad R. Hariri,

Elisabeth B. Binder 

Neuron Volume 86, Issue 5, Pages 1189-1202 (June 2015)

DOI: 10.1016/j.neuron.2015.05.034

Copyright © 2015 The Authors Terms and Conditions

Page 2: Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk- Related Brain Function and Psychiatric Disorders Janine Arloth, Ryan

Figure 1

Neuron 2015 86, 1189-1202DOI: (10.1016/j.neuron.2015.05.034) Copyright © 2015 The Authors Terms and Conditions

Page 3: Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk- Related Brain Function and Psychiatric Disorders Janine Arloth, Ryan

Figure 2

Neuron 2015 86, 1189-1202DOI: (10.1016/j.neuron.2015.05.034) Copyright © 2015 The Authors Terms and Conditions

Page 4: Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk- Related Brain Function and Psychiatric Disorders Janine Arloth, Ryan

Figure 3

Neuron 2015 86, 1189-1202DOI: (10.1016/j.neuron.2015.05.034) Copyright © 2015 The Authors Terms and Conditions

Page 5: Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk- Related Brain Function and Psychiatric Disorders Janine Arloth, Ryan

Figure 4

Neuron 2015 86, 1189-1202DOI: (10.1016/j.neuron.2015.05.034) Copyright © 2015 The Authors Terms and Conditions

Page 6: Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk- Related Brain Function and Psychiatric Disorders Janine Arloth, Ryan

Figure 5

Neuron 2015 86, 1189-1202DOI: (10.1016/j.neuron.2015.05.034) Copyright © 2015 The Authors Terms and Conditions

Page 7: Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk- Related Brain Function and Psychiatric Disorders Janine Arloth, Ryan

Figure 6

Neuron 2015 86, 1189-1202DOI: (10.1016/j.neuron.2015.05.034) Copyright © 2015 The Authors Terms and Conditions

Page 8: Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk- Related Brain Function and Psychiatric Disorders Janine Arloth, Ryan

Figure 7

Neuron 2015 86, 1189-1202DOI: (10.1016/j.neuron.2015.05.034) Copyright © 2015 The Authors Terms and Conditions