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Evolution in 21st Century Clinical Electrophoresis

V8 is revolutionising the laboratory for customers around the world. In 2012, Helena Biosciences launch the V8 E-Class — a second generation system with unique advancements to automation, analysis and useability.

ResultsSuperior separation, resolution and quantitation ■

Precise and accurate peak detection and band positioning ■

Unsurpassed shape matching ■

Sophisticated Levey-Jennings protocol ■

Optimised CE controls ■

UseabilityHigh definition on-screen trace images ■

Integrated CE and gel result display ■

Review Platinum off-line in Viewer Mode ■

Comprehensive language support ■

Simple, configurable user interface ■

Ultimate flexibility in LIMS connectivity ■

Up to 100,000 CE results for instant retrieval and analysis ■

Four user-defined buffer positions for on-board assay flexibility, ■

with automated assay switching and buffer availability

MethodsThree tailored serum protein methods for high speed screening ■

and high resolution diagnostic resultsUnique gel integration ideal for Serum Immunofixation, Urine ■

Analysis, Urine Immunofixation and Pentavalent ScreenGold-standard Haemoglobin Isoelectric Focusing method as ■

recommended by leading expertsAutomatic peak detection, labelling and band display for ■

crystal-clear interpretation and results reportingFully-automated Carbohydrate Deficient Transferrin (CDT) ■

method with on-board sample preparation

ReliabilityPre-flight check system for regular performance monitoring ■

Precise reagent and buffer level management ■

Instant user access to system monitoring messages ■

and error files for troubleshooting, service support and guaranteed operational uptime Log of PC–V8 communications ■

Log of PC–LIS/LIMS communications ■

Order capillary pre-condition and purging from ■

Platinum for system maintenance and optimisationComprehensive Platinum Help system ■

FutureproofingInpeco ■ ® FlexLab® integrationExtensions to database capacity ■

Network editing of diagnostic data ■

Improved communication of system status ■

LIS/LIMS host system query mode ■

Integration with QC lab middleware ■

Expert System for automated ■

diagnostic assistance

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Superior separation, resolution and quantitation for precision and accuracy

C MethodsA Results D Reliability E FutureproofingB Useability

1 Excellent Immunodisplacement result overlays leading to clearer and quicker interpretation. 2 Unsurpassed peak detection, sample baselining

and controls.

Consistent trough marker placement ■

Excellent baseline placement ■

Superior peak analysis ■

Second-pass peak detection ■

A2

Albumin

Alpha-1Alpha-2 Beta-1

Beta-2

Gamma M-spike

A

D-Punjab

Penta, Tetra

Tetra

Tri Di

Haemoglobin IEFSerum Protein (SP-6, SPE and Zoom) CDT

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Platinum 4.1 — an outstanding diagnostic software package.Platinum 4.1 continues to evolve to offer the most up to date, and user friendly software interface possible. With improvements to visual design, user options and software functionality, Platinum 4V is easier to use than ever.

A Results B Useability

2 Clear, easy to interpret trace displays.1 Platinum is now better-looking, more helpful and easier to use,

with improved icons, images and menus.

Viewer Mode for remote viewing of ■

Platinum filesComprehensive language and Help ■

system available within Platinum 4V

Clear on-screen trace display ■

Coloured trace display ■

Dynamic peak labelling ■

New and improved zone markers ■

Serum Protein

CDT

C Methods D Reliability E Futureproofing

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Sophisticated technology made simple.

Helena Biosciences have upgraded the already extensive functionality of the system to add new features and improve existing ones. These changes reinforce the V8’s position as the most capable and adaptable Clinical Capillary Electrophoresis system on the market.

1 Precise measurement of buffer usage and better display of buffer levels. 2 Unique on-board automated

gel integration technology.

Graphical ■

representation of buffer levels

Precise fluid ■

detection system

Facilitates efficiency ■

and workflow

Making capillary and gel ■

electrophoresis more compatible than everAutomated sample preparation for ■

SPIFE gel traysEnables V8 to support worldwide ■

Helena users

B UseabilityA Results C Methods D Reliability E Futureproofing

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Larger database capacity, and better system communication.Using new computer programming languages and software means that not only do we have a more up to date and robust system, we also have the ability to develop and integrate new technologies and features more rapidly.

1 State-of-the-art software development tools and new technologies for increased flexibility, power and performance. 2 New error reporting, better

support, for more uptime.

1GB2GB

2GB 4GB+

Error log accessible within Platinum for ■

simpler customer error reportingCommunication logs between the ■

Platinum PC and the V8 allow diagnostic troubleshootingCommunication logs between the ■

Platinum PC and LIS/LIMS to speed up the detection and resolution of data transmission issues

Latest Microsoft Access database software, immediately doubles the capacity of the database available and makes the storage of data more efficient.

Platinum 4.1 has had hundreds of code optimisations and new features added, leading to higher performance and more ease of use.

Newer software development tools make integrating future technologies and features easier, quicker and more cost-effective.

Future database size improvements possible as databases can be split into sub directories.

B UseabilityA Results C Methods D Reliability E Futureproofing

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Fully-automated, Gold-standard Haemoglobin IEF assay.V8 Haemoglobin IEF Assay from Helena Biosciences combines excellent automated performance with superb separation and quantitation capabilities, delivering fast and reliable results across a wide range of haemoglobin variants.

C Methods

1 Platinum delivers a clear, user-friendly trace display facilitating rapid and precise results for interpretation and diagnosis.

Clear display in the Platinum analysis window ■

with focus on the important elements of the traceSuperior separation of Haemoglobin fractions, ■

particularly A and F for excellent at-a-glance interpretationPlatinum 4.1’s automatic intelligent peak ■

recognition algorithms deliver outstanding peak identification and labellingEasy-to-use coloured bands on trace display, ■

for clearly delineated peaksDynamic peak labelling on the graph for ease ■

of identificationComparison of run position against historical ■

data allowing for precise typingExtensive Haemoglobin variant library enables ■

the identification of unusual variants using previously identified samples

Z1100

50

00 50

PreA F

AS

A2

100[%]

Z2 Z3 Z4 Z5 Z6 Z7 Z8 Z9 Z10 Z11

A Results D Reliability E FutureproofingB Useability

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Fully-automated Carbohydrate Deficient Transferrin assay, from sample preparation to results reporting.Our high-specification CDT assay delivers full automation of rack and sample handling, making it very easy to use.

1 Sample pre-treatment is no longer required. Iron saturation is now handled automatically and on-board.

2 All racks can be loaded at once and processed automatically without loss of resolution, reproducibility or accuracy.

3 Improved sample traceability as analytes can now be loaded and analysed from their primary tubes.

C MethodsA Results D Reliability E FutureproofingB Useability

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On-board diagnostics panel for a ‘pre-flight check’ of your system’s performance.Designed for end-users and service engineers, Platinum 4.1 incorporates a diagnostic audit system to verify that your V8 is running within the parameters specified by the manufacturer, helping to ensure the system’s optimal performance.

1 System Audit Mode: track the performance of the system through sample analysis for precise diagnostic troubleshooting. 2 Communication error logging

for rapid diagnostics.

Audit system performance to evaluate:

Whether all indicators are within tolerance ■

and running according to Helena Biosciences’ performance specificationsIdentify the potential causes of poor system ■

performance or unexpected results

The facility offers the ability to measure a number of performance indicators:

Temperature ■

Voltage ■

Current ■

Pressure ■

Fluid levels ■

Error log accessible within Platinum for ■

simpler customer error reportingCommunication logs between the Platinum PC ■

and the V8 allow diagnostic troubleshootingCommunication logs between the Platinum PC ■

and LIS/LIMS to speed up the detection and resolution of data transmission issues

D ReliabilityA Results E FutureproofingB Useability C Methods

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Total control for system maintenance and performance optimisation.Avoid time-consuming pre-conditioning and purging steps to ensure maximum system uptime and performance. At the click of a mouse the operator can purge and pre-condition the system easily and efficiently — all without workflow interruption.

1 Direct commands to the V8 give you total control over the analyser, saving time and money. 2 Avoid time-consuming analyser re-starts with new

purge and pre-conditioning overrides.

New Platinum feature allows ■

control over buffer and capillary purges

Order an extra wash of the ■

fluid lines with the new force purge option

Order an additional capillary ■

wash with the new force precondition option

D ReliabilityA Results E FutureproofingB Useability C Methods

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Inpeco® Integration — the art of automation.

The V8 E-Class will be the first Clinical Capillary Electrophoresis analyser that can be used in conjunction with the market-leading FlexLab® laboratory automation system. This unique system will offer laboratories a fully-automated clinical electrophoresis analyser without any operator intervention.

E Futureproofing

1 Modular V8 analytical platform to offer full compatibility with the FlexLab automation system. 2 Platinum enhancements offer

benefits to all customers.

These new features will provide additional functionality, both to Inpeco and non-Inpeco users:

Better LIS / LIMS integration enables ■

host system query functionality, to receive the specific test requirements of each sample

Better integration with laboratory ■

middleware and 3rd party QC packages

Development of the Expert system to ■

automate the reflex testing of abnormal samples

Support for cap piercing and sample ■

agitation for Haemoglobin analysis

V8 receives sample from FlexLab system and queries middleware for test details

XYZ arm takes sample from the primary tube

Analysis result automatically returned to FlexLab middleware

A Results B Useability C Methods D Reliability

V8 from Helena Biosciences is already transforming laboratories around the world. Find out below how we can improve your results, efficiency and performance.

The key feature of the V8 is the quality and dedication of our Sales, Service and Support teams who work closely with our local distribution partners to get the solutions to you quickly, efficiently and cost-effectively.

Helena Biosciences Europe

Queensway South, Team Valley Trading Estate Gateshead, Tyne and Wear, NE11 0SD United Kingdom

www.helena-biosciences.com

Tel +44 (0)191 482 8440 Fax +44 (0)191 482 8442

sales@helena-biosciences.com marketing@helena-biosciences.com

HL-2-2655P 2012/11 (1). © Copyright 2012 Helena Biosciences Europe. All rights reserved.

1 Helpful and efficient local sales operations. 2 Service programme to keep

your V8 running all year. 3 Skilled support team to get you back to work rapidly.

We pride ourselves in working with customers and our local representatives to deliver the very best product to you:

Rapid product ordering and delivery ■

Dedicated team of Product Specialists ■

enable customers to influence product design and development

Competitive pricing ■

The V8’s efficiency and reliability will maximise laboratory up-time, and are further supported by our comprehensive service and maintenance programme:

System backup and installation support ■

Annual product health-check ■

Access to regular product updates ■

When problems do occur, we have the best technical support to get your laboratory up and running again:

Local service teams trained to Helena ■

Biosciences standards

On-call Helena Biosciences support ■

specialists can make site visits

Dedicated support via telephone ■