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Dual Modality Ultrasound-SPECT Detector for Molecular Imaging
R. Pani1,2, R.Pellegrini1,2, M.N. Cinti1,2, S. Ridolfi1,2, R. Scafe'1,2, G. De Vincentis1,3, E. Di Castro1,3, M. Mattioli1, P. Boccaccio4, G.
Moschini4,5, N.Lanconelli6,7, S. Lo Meo6,7, D. Sacco8,9, A. Fabbri8,10, P. Bennati8,10, V. Orsolini Cencelli8,11, T. Baroncelli8, F. de
Notaristefani8,11 and F. Navarria6,7
1INFN, Roma1, 2 Dept of Experimental Medicine, .Sapienza. Univ., Rome, 3Dept of Radiology .Sapienza. Univ., Rome, 4LNL-INFN, Padova,5Physics Dept, Univ. Padua, 6INFN , Bologna, 7Physics Dept, Bologna Univ., 8INFN Roma3, 9ISPESL Monteporzio Rome,
10EDEMOM PhD School of Electronics, .Roma Tre. University, Rome, 11 Physics Dept, .Roma Tre. University, Rome Italy
ECORAD dual modality imager ECORAD dual modality imager 3D gamma ray & 3D US3D gamma ray & 3D US
US
Gamma
US
Gamma
2D gamma ray & 3D US2D gamma ray & 3D US
• The ECORAD collaboration aims to develop a dual compact system for imaging in Medicine, integrating an US-probe with a compact gamma camera.
• ECORAD dual modality imager is planned to obtain functional (Radionuclide imaging) and anatomic (Ultrasound Imaging) information for a more reliable diagnosis in Medicine.
• Ultrasounds (US) are a cost-effective and reliable method, representing an easy ways to assemble a portable devices.
Calibration Experiment: 3D US & 2D GammaCalibration Experiment: 3D US & 2D Gamma
“Biological “ Experiment: 3D US & 2D Gamma“Biological “ Experiment: 3D US & 2D Gamma
Egg after injection
(20 µµµµl Tc99m + methylene blue
Coronal US Image
(from 3D reconstruction)
2D Gamma Image2D Gamma Image 3D US & 2D gamma3D US & 2D gamma
Gamma CameraGamma Camera3D US /2D gamma imager module3D US /2D gamma imager module
Co-registration System Co-registration System
Fused US-Gamma images
The SPECT/US hybrid imager is the first integrated detector able to carry out fusion of morphological (anatomical) and functional contents for medical application.
The scintillation detector will be able to reconstruct volume image by an advanced reconstruction algorithm for gamma ray tomosynthesis dedicated to slant collimator, without a tomographic ring.
First generationFirst generation
Ultrasound Piezoelectric Probe:
256 pixel -10 MHz
Outer dimension: 45 mm x 12 mm
US C-scan to obtain 3D US images
Gamma Camera module
Ultrasound Probe
Transverse Plane Sagittal Plane
30 mm
10 mm
20 mm
30 mm
40 mm
10 mm
20 mm
30 mm
40 mm
Coronal Plane ( from 3D reconstruction)
Capillary #2
Capillary #1
Capillary #1
Capillary #2
Front view
• 2 capillaries • ID=0.2 mm – OD= 0.6 mm
• Volume 1 µl• 0.1mCi Tc99m in each capillary
Fused US Coronal images-Gamma imagesFused US Coronal images-Gamma imagesUS imagesUS imagesUS - Gamma PhantomUS - Gamma Phantom
The two capillaries are visible in two different slides of the coronal plane . The false color image represents the functional
information coming from gamma detector, where the two capillaries are visible simultaneously.
Sagittal plane
Transverse plane
Coronalplane
Capillary #1
Ca
pil
lary
#2
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Read-out electronics main issues:
- 256 independent channels
- 250Ksample/s - max event-rate
- FPGA based control board
- 14 bit ADC dynamic range
Energy Resolution: 6.5 % @140 keVIntrinsic Spatial Resolution 0.9 mm
10 x 10 cm2 FoV gamma camera
LaBr3:Ce Continuous Scintillation Crystal
2x2 array of MA-PMT Hamamatsu H8500-Mod8
CORRESPONDING AUTHOR: [email protected]
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