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Dual Energy CT of The Heart Dual Energy CT of The Heart U. Joseph Schoepf, U. Joseph Schoepf, MD, FAHA, FSCBT MD, FAHA, FSCBT MR, FSCCT MR, FSCCT Professor of Radiology, Medicine, and Pediatrics Professor of Radiology, Medicine, and Pediatrics Director of Cardiovascular Imaging Director of Cardiovascular Imaging

Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

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Page 1: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

Dual Energy CT of The HeartDual Energy CT of The Heart

U. Joseph Schoepf, U. Joseph Schoepf, MD, FAHA, FSCBTMD, FAHA, FSCBT‐‐MR, FSCCTMR, FSCCTProfessor of Radiology, Medicine, and PediatricsProfessor of Radiology, Medicine, and PediatricsDirector of Cardiovascular ImagingDirector of Cardiovascular Imaging

Page 2: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

Consultant for / research support from 

Bayer

Bracco

General Electric

Medrad

Siemens

Disclosures

Page 3: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

Primary morphological vs. functional evaluation of CAD (i.e. SPECT vs. ICA, CTA)?Early attempts at CT imaging

Limited by experimental natureLimited by dedicated acquisition protocols

Hybrid Imaging (e.g. SPECT and CT)Dual‐energy CT for myocardial perfusion defectsDelayed enhancement dual‐energy CT Adenosine stress dual‐energy CT

Integrative CHD Imaging with CT

Page 4: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

140kV

80 / 100kV

Integrative Imaging: DECT

Page 5: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

7474‐‐yo woman yo woman with chest pain with chest pain and abnormal and abnormal SPECTSPECT

2x64x0.6mm, 2x64x0.6mm, 80kV/140kV80kV/140kV0.33 s rotation 0.33 s rotation timetime

DECT for Myocardial Ischemia 

Page 6: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

7474‐‐yo woman with chest pain yo woman with chest pain and abnormal SPECTand abnormal SPECTTight proximal stenosis D1Tight proximal stenosis D1

Morphology and Function: DECT

B. Ruzsics et al., Circulation 2008

Page 7: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

7474‐‐yo woman yo woman with chest pain with chest pain and abnormal and abnormal SPECTSPECT

B. Ruzsics et al., Circulation 2008

Morphology and Function: DECT

Page 8: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

DECT Postprocessing

F. Schwarz et al., Eur J Radiol 2008

Page 9: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

JM Kerl et al., Eur Radiol 2010

DECT Radiation Dose

16‐Slice CT DSCT DECT12 ± 3.59 mSv         9.8 ± 4.77 mSv      4.54 ± 1.87 mSv

Page 10: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support
Page 11: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

DE cCTA LAD

DECTSPECT

36 36 yoyo woman,  DM I woman,  DM I 

hoho LAD infarctLAD infarct

Page 12: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

Reversible Ischemia at Rest DECT

61 yo man, atypical chest pain

Page 13: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

DECT Can Detect Subtle Pathology

Vliegenthart et al., AJR in press

Page 14: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

Delayed Enhancement DECT

B. Ruzsics et al., HEART 2009

Page 15: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

cCTA

Delayed

FirstPass

LAD

Delayed Enhancement DECT

B. Ruzsics et al., HEART, in press

Page 16: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

Delayed Enhancement DECT

Ruszsics et al.,RSNA 2009

Page 17: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

0 1 week‐1 month

Abnormal SPECT

rest and/or stress

Rest DECT

AdenosineDECT

DelayedDECT

(sequential)

Rest ceMRI(perfusion)

Adenosine ceMRI(perfusion)

Delayed Enhancement(viability)

Adenosine protocol: 140 µg/min/kg 

Adenosine Stress DECT

B. Ruzsics et al., AHA 2008

Page 18: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

LM

D1LAD

Reversible Ischemia

Adenosine Stress DECTAdenosine Stress DECT

Page 19: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

Adenosine Adenosine Stress cMRIStress cMRI

Reversible Ischemia

Page 20: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

Rest Stress Delayed

Reversible Ischemia

Page 21: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

• Larger scan field of view (SFOV) for Dual Energy modes

• SFOV A/B‐detector: 50/33 cm

Next Generation DECT

33 cm

Page 22: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

S1: 80 kV

x 10415

10

5

0 50 100 150

80 kV140 kV

photon energy (keV)

numbe

r of qua

nta

0.4 mm Sn

+ SPS

140 kV + SPS

S2: 140 kV

• Dual Energy with Selective Photon Shield

• Improved separationof low and high energies

• Noise reduction• Greater dose reserve

Next Generation DECT

Page 23: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

83 msec 83 msec TTemporalemporal RResoesolution in Duallution in Dual‐‐Energy ModeEnergy Mode

165 msec 83 msec

DECT Temporal Resolution

Page 24: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

Next Generation DECT

Page 25: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

Rest

Stress

Quantitative DECT Perfusion

Page 26: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

Promising developments for DECT imaging of the myocardial blood supply and viability CT not the primary method for evaluation of myocardial perfusionCTA is mainly aimed at imaging the coronariesCT a possibly attractive modality for integrative imaging of anatomy and perfusionFurther refinements in technique impending

Summary – Future Perspectives

Page 27: Dual Energy CT of Heart - Society for Advanced Body Imaging · 2013-12-05 · Dual Energy CT of The Heart U. Joseph Schoepf, MD, FAHA, FSCBT ‐MR ... Consultant for / research support

[email protected]@musc.edu