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Dr. Mervat Mamdooh Khorshied

Personal information (C.V)

2012

CONSU

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CURRICULUM VITA(C.V) Personal information (C.V) /2012

Name: Mervat Mamdooh Ahmed Khorshied.

Marital status: Married.

Nationality: Egyptian.

Date of Birth: 1/12/1969.

Place of Birth: Cairo, Egypt.

Religion: Muslim.

Telephones;

Home; +202 33037080

Mobile; 0101593441

Address: 23 st Gezeret El Arab, El Mohandseen, Giza, Egypt.

Current Job Status: Assistant Professor of Clinical and Chemical Pathology,

Faculty of Medicine, Cairo University.

E- mail: mervatkhorshied@hotmail.com.

Professional experience:

November, 1995: M.B.,B.Ch.

Faculty of Medicine, Cairo University.

Excellent with honors, rank: 33 rd.

May, 2000: M.Sc. in Clinical and Chemical Pathology

Faculty of Medicine, Cairo University.

Thesis title: The diagnostic value of reticulated platelets

measurement in patients with immune thrombocytopenic

purpura (ITP).

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December 2004: M.D. in Clinical and Chemical Pathology

Faculty of Medicine, Cairo University.

Thesis title: Ex-vivo expansion of stem cells:

Defining optimum conditions using various cytokines.

Laboratory experience:

-Participating in scientific, technical and administrative supervision of different clinical

pathology laboratory tests in Kasr Al Aini Teaching Hospital, Cairo University.

-Supervision and practicing the assistant lecturers, residents' doctors and laboratory

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: technicians in Kasr Al Aini Teaching Hospital ,Cairo University.

-Participating in preparation and examination of different annual laboratory requirements

and supplies.

-Participating and supervision of quality control and assurance in Kasr Al Aini Teaching

Hospital, Cairo University.

-Performing and interpreting the different hematological techniques (qualified in molecular

techniques (PCR) and Stem cell culture techniques).

Attendance and training courses:

Certificated from Cairo University as a University Lecturer

Faculty and Leadership Development Programs of Cairo University;

Attending and passing the Scientific Research Methods program.

Attending and passing the Medical and Professional Ethics

program.

Attending and passing the Preparing and International Publishing

of Scientific Researches program.

Attending and passing the Teaching for Small and Large Groups program

Attending and passing the Quality standards in the teaching

process program.

Teaching:

Teaching the practical course of master degree of Clinical Haematology- First part

(From 2007 till now).

Practical examination of Clinical Haematology- First part (Fron 2007 till now).

Tutorial teaching for master degree students of Internal Medicine- First part (2007-

2009).

Tutorial teaching for master degree students of Clinical and Chemical Pathology- First

part (2009/2010, 2010/2011).

Participation in Practical examination of master degree students of Clinical and

Chemical Pathology (First and Second parts) (From 2005 till now).

Master Degree first/second Part lectures:

-Haematopoiesis.

- Haemogram and normal blood cells.

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-Manual and automated blood cells counting.

-Interpretation of peripheral blood count, differential count, staining of peripheral blood

smears.

-Calibration of automated blood cell counters.

-Immune hemolytic anemia.

Publications:

1-Expreeion and Clinical Implication of ZAP-70 in Acute Lymph-oblastic

Leukemia. Khorshied M,Gouda H, Mohsen I A, Sroor M, AL-Bolkeny TN. Journal of Medical

Science 2008.8(5) 461-468.

; http://scialert.net/pdfs/jms/2008/461-468.pdf

2-The Clinical Relevance of Cyclin A1 over Expression in Acute Myeloid

Leukemia. EL-Guindy N M, Khorshied M, Gouda H, Shaheen I A, Abu Khalil R E, Sroor M,

AL-Bolkeny TN. The Egyptian Journal of Haematolo-gy .2008.33(4);362-369

3-The osteogenic differentiation potentials of umbilical cord blood

haematopoietic stem cells. Mervat M. Khorshied ; Heba M. Gouda ; Iman A. Shaheen

Tarek N. Al Bolkeny. Comparative Clinical Pathology. Accepted for publication-2010.

http://www.springerlink.com/content/47h70418549ll761/

4-Clinical relevance of angiopoietin-1, angiopoietin-2, and their receptor Tie-2

expression in acute myeloid leukemia. Safaa M. El Karaksy, Nancy M. El Guindy, Heba

M. Gouda, Mervat M. Khorshied, Iman A. Shaheen, Reham E. Abu Khalil, Noha Y. Ibrahim.

Comparative Clinical Pathology. April- 2010.

http://www.springerlink.com/content/47h70418549ll761/

*Presented as a Poster and published in the abstract book of the American Association for

Cancer Research (AACR), Dead Sea- Jordan, March 2010.

5-The clinical significance of methylenetetrahydrofolate reductase (MTHFR)

polymorphisms in acute lymphoblastic leukemia. Hanaa

H. Arnaout, Mervat M. Khorshied, Iman A. Shaheen, Heba M. Gouda, Noha Y. Ibrahim,

Naglaa F. Koura. Comparative Clinical Pathology. June- 2010.

http://www.springerlink.com/content/f475876uw14w2157/

*Presented as a Poster in the 21St International Conference of Anti-Cancer treatment (ICACT),

Paris, Palis de Congres, Feb. 2010

6-Identification and clinical evaluation of the receptor for Hyal-uronic acid

mediated motility (RHAMM/CD 168) in AML patients: Khorshied M., Omar D. Pan

Arab Journal of Oncology | vol 3; issue 2 | June 10

http://www.amaac.info

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7-PRAME and WT1 Genes Expression in Chronic Myeloid Leukemia Patients:

Clinical Importance and Future Prospects. Eyada T., Kamal

El Dim M., Khorshied M., Zayed R., Soliman A., Omar D. Pan Arab Journal of Oncology, vol.2;

issue 3, Sept. 2009.http://www.amaac.info.

8- Nucleophosmin gene mutation in acute myeloid leukemia patients

Khorshied MM, Said WA, Shaaban HA. Saudi Med J. 2010 May;31(5):582-4. PMID:

20464055 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/20464055.

9-The role of Nucleophosmin gene mutation and Flt-3 internal tandem

duplication as molecular prognostic markers in AML. Khorshied MM, Said WA,

Shaaban HA. Journal of Egyptian Society of Haematology, Dec. 2009.

10-Prognostic implication of BAALC gene expression in de novo

acute myeloid leukemia patients. Eyada T., El Danasouri N., Gouda H., Khorshied M.,

Mokhtar D., Omar D. Egyptian Journal of Internal Medicine.

Jan-Apirl, 2009.

11-Expresasion and clinical implication of Cyclic adenosine monophosphate

response element binding protein (CREB) in de novo AML. Aisha Mostafa, Mervat

Khorshied, Heba Gouda, Mahmoud Sroor. Egypt. J. Lab. Med. Vol.20, No. 1,2,3 Feb., June,

Oct., 2008.

12- Expression of vascular endothelial growth factor and its receptors FLT-1 and

KDR in acute leukemia: Clinical relevance and future prospects. El Sheemy N.,

Salah El Din M., Leheta N., Shaheen N., Khorshied M., El Messery L., Al Ghonemy E. The

Medical Journal of Cairo University. Vol.75, No. 2, Suppl.

June 2007. http://www.medicaljournalofcairouniversity.com.

13- Effect of Uremia on polymorphnuclear leucocytes activity and apoptosis. El

Khateeb M., El Fayiad T., El Sirsawy G., Taha A., Aly M., Al Fishawy H., El Khashab O.,

Khorshied M., Gouda H., Abdel Rahman S. The Egyptian Journal of internal Medicine, Vol.

19, No. 1, Jan.2007, 57-69. http://www.esim.org.eg.

14- Autologous melanocyte–keratinocyte suspension in the treatment of vitiligo.

BM El-Zawahry, NS Zaki, DA Bassiouny, RM Sobhi, A Zaghloul, MM Khorshied and HM

Gouda. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND

VENEREOLOGY. Article first published online : 21 JUN 2010, DOI: 10.1111/j.1468-

3083.2010.03759. http://www.blackwell-synergy.com/loi/jdv.

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15-Ex Vivo Expansion of Stem Cells: Defining Optimum Conditions Using

Various Cytokines. AZZA A. MOHAMED, AZZA M. IBRAHIM, MANAL W. EL-MASRY,

IMAN M. MANSOUR, MERVAT A. KHROSHIED, HEBA M. GOUDA, RAAFAT M. RIAD.

Laboratory Hematology; volume 12, Number 2 / June 2006.

16- Flow cytometric detection of leukemic stem cells (LSCs) in Egyptian pediatric B-acute lymphoblastic leukemia. Manal W. El-Masry, Mervat M. Khorshied, Iman A. Shaheen, Nelly N. Abulata, Tarek A. Hashem. Comp Clin Pathol. DOI 10.1007/s00580-011-1214-7

17- Quantitative Assessment of Wilms Tumor 1 (WT1) Gene Transcripts in

Egyptian Acute Lymphoblastic Leukemia Patients. Ali Sadek H, El-Metnawey

WH, Shaheen IA, Korshied MM, Mohamed AS. J Investig Med.

18. FcγRIIa and FcγRIIIa genetic polymorphisms in a group of pediatric immune thrombocytopenic purpura in Egypt.Tayseer K. Eyada, Hala M. Farawela, aMervat M. Khorshied, aIman A. Shaheen, aNeama M. Selim, bIman A.S Khalifa Blood Coagulation & Fibrinolysis. 2011 Oct. [Epub ahead of print].

19. Association of C46T genetic polymorphism of coagulation factor XII with deep

venous thrombosis: a cohort study on Egyptian patients. Naguib M. Zoheir, Mona S.

Hamdy, Mervat M. Khorshied, Nelly N. Abulata, Mehry El Sobky, Amr M. Saleh, Hussein M.

Khairy. Comp Clin Pathol DOI 10.1007/s00580-011-1387-0.

20.Tumor necrosis factor alpha−308 and Lymphotoxin alpha+252 genetic

polymorphisms and the susceptibility to non-Hodgkin lymphoma in Egypt.Azza

Ibrahima, Hala Abdel Rahmana, Mervat Khorshieda, Rania Samia, Nelly Nasra, Ola Khorshid.

Leuk Res (2011), doi:10.1016/j.leukres.2011.11.016.

21. Mannose binding lectin (MBL2) gene polymorphism in sickle cell anaemia: an Egyptian study". Menat Allah Kamal El Deen, Mervat M. Khorshied, Zeinab A. El Sadani, Yasmine M. Amrousy, Nermeen M. Galal. Comp Clin Pathol. DOI 10.1007/s00580 -012-1420-y. Hala A. Shaheen, Mervat Khorshied, Mohammad A. El-Sayed, Mohammad A. Taha. Post Stroke Infection; Frequency and Immunosuppression Contribution. Egypt J Neurol Psychiat Neurosurg. Vol 49 │ Issue 3; 139-244. Khorshied MM, El-Ghamrawy MK. DNA methyltransferase 3B (DNMT3B -579G>T) promotor

polymorphism and the susceptibility to pediatric immune thrombocytopenic purpura in Egypt.

Gene. 2012 Dec 10;511(1):34-7.

Farawela H, Khorshied M, Shaheen I, Gouda H, Nasef A, Abulata N, Mahmoud HA, Zawam

HM, Mousa SM. The association between hepatitis C virus infection, genetic

polymorphisms of oxidative stress genes and B-cell non-Hodgkin's lymphoma risk in Egypt. Infect

Genet Evol. 2012 Aug; 12(6):1189-94.

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Abdel Rahman HA, Khorshied MM, Elazzamy HH, Khorshid OM. The link between genetic

polymorphism of glutathione-S-transferases, GSTM1, and GSTT1 and diffuse large B-cell

lymphoma in Egypt. J Cancer Res Clin Oncol. 2012 Aug;138(8):1363-8.

Khorshied MM and Bassiouny DA. Glutathione S-transferase M1 and T1 genetic polymorphism in

Egyptian patients with nonsegmental vitiligo. Clinical and Experimental Dermatology. Article first

published online: 8 JUN 2012.

Farawela H, Khorshied M, Shaheen I, Gouda H, Nasef A, Abulata N, Mahmoud HA, Zawam

HM, Mousa SM. The association between hepatitis C virus infection, genetic

polymorphisms of oxidative stress genes and B-cell non-Hodgkin's lymphoma risk in Egypt. Infect

Genet Evol. 2012 Aug; 12(6):1189-94.

Hanaa Hamed Arnaout1, Mervat Mamdooh Khorshied1, Ola M. Reda Khorshid2* and Mona

Hazem El-Nagdy. Association of Caspase 8 and Caspase 10 Genetic Polymorphisms with B-cell

Non Hodgkin’s Lymphoma in Egypt: A Case-Control Study. J Cancer Sci Ther Volume 4(9) 249-

253 (2012) – 249.

El-Zawahry BM, Azzam OA, Zaki NS, Abdel-Raheem HM, Bassiouny DA, Khorshied MM. PTPN22 gene polymorphism in Egyptian alopecia areata patients and its impact on response to diphencyprone immunotherapy. Gene. 2013 Apr 6. pii: S0378-1119(13)00339-9. doi: 10.1016/j.gene.2013.03.070. [Epub ahead of print]

Research projects:

Project 1:

Genetic polymorphism of oxidative stress genes and the risk of NHL and its

relevance to HCV infections.

Participants:

Hala Farawela, MD; Mervat Khorshied, MD; Aya Nassef, MD; Somaya Abdel Rahman,

MD; Heba Gouda, MD; Iman Abdel Mohsen, MD, Nelly Abulata, MD and Hamdy El Zawam*,

MD. Department of Clinical and Chemical Pathology, *Department of Oncology, Faculty of

Medicine, Cairo University, Egypt.

Project 2:

The Evaluation of C-Reactive protein, Procalcitonin, and CD64 as an Adjunctive

Tool for Diagnosing Ventilator Associated Pneumonia (VAP).

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Participants:

Ahmed Mokhtar, MD, Mervat Khorshied*, MD. Heba M. Gouda*, MD, Riham El Sayed*,

MD. Department of Anaesthesia, *Clinical and Chemical Pathology Department, Faculty of

Medicine, Cairo University, Egypt.

Project 3:

Analysis of monocyte chemotactic protein-1 gene polymorphism in Egyptian

cirrhotic patients with spontaneous bacterial peritonitis and other infections

Participants:

Mahasen Mabrok, MD; Dalia Omran, MD and Mervat Khorshied*, MD.

Department of Tropical Medicine, *Department of Clinical Pathology, Faculty of Medicine,

Cairo University

Supervision on Master and MD thesis of Clinical and Chemical pathology:

Starting from April 2005 till now.

Attendance and participation in workshops:

1- Basic Stem Cell Culture at Tissue Culture and Cytogenetic Unit, Department of

Clinical Pathology, Kasr El-Aini Faculty of Medicine, Cairo University. Jun2e 2006.

2- Cardiovascular Cell Therapy at Faculty of Medicine, Cairo University. May, 2008:

Tissue culture and experimental work.

3- Haematopathology and Immunohistochemistry Workshop at the National

Cancer Institute, Cairo University. Jan, 2009.

4- Publishing Scholarly Journals- ELSEVIER, at STMPU-Cairo University, Dec.

2009.

Attendance of Conferences and workshops:

The 6th International Conference for Thalassemia. Update in Thalassemia (From

Prevention to Gene Therapy). May 2005.

The 3rd Annual Meeting of Clinical Pathology –Al Azhar University. The Role of

Laboratory in Early Diagnosis. September 2005.

The 27th Annual Meeting of The Egyptian Society of Haematology (ESH),In

Collaboration with The Egyptian Association of Transfusion Medicine (EATM). Dec.

2005.

The 53th Scientific Conference of The Egyptian Society of Clinical Chemistry (ESCC) -

International meeting. Dec. 2005.

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The 2nd International Conference of Egyptian Society of Hematology and Research

(ESHR). February 2006.

The 4th International Congress of The Egyptian Society of Pediatric Hematology and

Oncology (ESPHO). March 2006.

The XVII Conference of The Egyptian Society Of Laboratory Medicine. March, 2006.

The 28th Annual Meeting of The Egyptian Society of Haematology (ESH),In

Collaboration with The Egyptian Association of Transfusion Medicine (EATN) .

December 2006.

The 28th Annual Meeting of The Egyptian Society of Haematology (ESH),In

Collaboration with The Egyptian Association of Transfusion Medicine (EATM). Jan.

2007.

The 18th Annual Conference of The Egyptian Society of Laboratory Medicine. The

Laboratory ;From Self-Evaluation to Accreditation. March 2007.

The 5th International Congress of The Egyptian Society of Pediatric Hematology and

Oncology (ESPHO). March 2007.

The 3rd International Conference of Egyptian Society of Hematology and Research

(ESHR) .April 2007.

The 8th International Thalassemia Conference. May 2007.

The 29th Annual Meeting of The Egyptian Society of Haematology (ESH),

In Collaboration with The Egyptian Association of Transfusion Medicine (EATM). Jan.

2008.

The 4th International Conference of Egyptian Society of Hematology and Research

(ESHR). February 2008.

The 6th International Congress of The Egyptian Society of Pediatric Hematology and

Oncology (ESPHO). March 2008.

The 9th International Thalassemia Conference. In May 2008.

The 7th International Congress of The Egyptian Society of Pediatric Hematology and

Oncology (ESPHO). March 2009.

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The 10th International Thalassemia Conference. In May 2009.

XXth Congress of the International Society of Haematology-European and African

Division ISH-EAD. Oct. 2009.

The 30th Annual Meeting of The Egyptian Society of Haematology (ESH),In

Collaboration with The Egyptian Association of Transfusion Medicine (EATM). Jan.

2010.

Poster presentation at the 21St International Conference of Anti-Cancer treatment

(ICACT), Paris, Palis de Congres, Feb. 2010.Poster entitled Identification of Leukemia

stem cells in pediatric B-cell precursor ALL.

The 8th International Congress of The Egyptian Society of Pediatric Hematology and

Oncology (ESPHO). March 2010.

Attendance and participation in The 1st Annual Scientific Conference of the Clinical and

Chemical Pathology Department Cairo University.

(Accredited by UEMS-EACCME ). Poster presentation .April 2010.

56th Annual Meeting Scientific and Standardization Committee of International Society

on Thrombosis and Haemostasis (ISTH). May2010.

- The annual conference of the Egyptian Society of Laboratory Medicine (ESLM-2012).

- Participated as a Speaker at The annual conference of the Egyptian Society of Laboratory

Medicine (ESLM-2012).

- The annual conference of the dept.; CLINCHEM 2012

- The International Conference for Thalassemia.

- The Annual Meeting of The Egyptian Society of Haematology (ESH),In Collaboration with

The Egyptian Association of Transfusion Medicine (EATN).

Membership of the Scientific Societies:

Membership of the Egyptian Society of Laboratory Medicine.

Membership of the Egyptian Society of Haematology.

Current activities:

- Member of the editorial board of the Egyptian Journal of Laboratory Medicine.

منسق لجنة ادارة توكيد الجودة و المراجعه الداخليه لقسم الباثولوجيا االكلينيكيه و الكيميائيه -

Computer skills:

Certificated from Cairo University in computer skills.

Special skills in dealing with word, Excel and power point programs.

Good dealing with internet.

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Language:

Arabic: Mother tongue.

English: Excellent spoken & written. Test of English as a Foreign

Language (TOEFL) certificated.

Other skills and attitude:

Strategic and practical analysis.

Self-motivated.

Self Trained.

Discipline.

Teamwork oriented.

Valid driving license.

References available upon request

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1996- 1997

1997-2000

2001- 2004

2005- 2010

Starting from July

2010

Rotating Internship (House Officer)

Faculty of Medicine (Kasr Al Aini Teaching Hospital), Cairo

University.

Resident of Clinical and Chemical Pathology, Faculty

of Medicine (Kasr Al Aini), Cairo University.

Assistant Lecturer of Clinical and Chemical

Pathology, Faculty of Medicine (Kasr Al Aini), Cairo

University.

Lecturer of Clinical and Chemical Pathology, Faculty

of Medicine (Kasr El Aini), Cairo University.

Assistant Professor of Clinical and Chemical

Pathology, Faculty of Medicine (Kasr Al Aini), Cairo

University.

Education: