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Albert de la ChapelleCurriculum Vitae

CURRICULUM VITAEAlbert de la Chapelle, M.D., Ph.D.

Name Albert de la Chapelle

Date and Place of Birth February 11, 1933, Helsinki, Finland

Nationality FinnishPermanent Resident, USA

Business Address Human Cancer Genetics ProgramComprehensive Cancer Center

The Ohio State University646 Medical Research Facility

420 West 12th

AvenueColumbus, OH 43210614/688-4781- Phone614/688-4772 - Faxe-mail: [email protected]

Current Major Positions

2004 - Distinguished University Professor, The Ohio State University (OSU)2004 - Cancer Scholar, OSU1997 - Leonard and Charlotte Immke Professor of Cancer Genetics, Department of Molecular

Virology, Immunology and Medical Genetics, OSU1997- Co-director, Molecular Biology and Cancer Genetics Program, Comprehensive Cancer

Center and Arthur G. James Hospital and Richard J. Solove Research Institute, OSU1999 - Professor, Division of Human Genetics, Department of Internal Medicine, College of

Medicine and Public Health, OSU2000 - Professor, Department of Molecular Genetics, College of Biological Sciences, OSU

Education1941-1950 Nya Svenska Läroverket: (High School) Helsingfors, Finland, graduated 19501950-1957 University of Helsinki, Finland. Faculty of Medicine. MD 19571958-1962 University of Helsinki, Finland. Faculty of Medicine. Ph.D. Human Genetics 1962

Certifications1957 - Licensed to practice medicine, Finland1965 - Board certified in Internal Medicine, Finland1986 - Board certified in Clinical Genetics, Finland

Previous Major Positions1969 -2003 Head, The Folkhälsan Institute of Genetics, Helsinki, Finland1974 -1997 Professor and Chairman, Department of Medical Genetics, University of Helsinki,

Finland1977-1997 Physician-in-Chief, Clinical Genetics, Helsinki University Central Hospital,

Finland1990-1997 Head, Hereditary Disorders Research Unit and Center of Excellence, University

of Helsinki, Finland1997 - 2004 Head, Division of Human Cancer Genetics, Department of Molecular Virology,

Immunology Medical Genetics, College of Medicine and Public Health, OSU1997 - 2004 Director, Human Cancer Genetics Program, Comprehensive Cancer Center and

Arthur G. James Hospital and Richard J. Solove Research Institute, OSU1999 – 2002 Director, Division of Human Genetics, Department of Internal Medicine, OSU


Fellowships, Medical and Academic Appointments

1955 Studied cardiology at Hôpital Boucicaut (Professor J. Lenègre), Paris, as recipient of French Government Stipend (3 months)

1958 Ship Doctor, The Johnson Line (South America) (3 months)

1958-1962 Resident, Internal Medicine (17 months) Diagnostic Radiology (9 months), Gynecology (2 months), Helsinki Teaching Hospitals, Finland

1956-1957 General Practitioner (3 months)

1959-1962 Junior Investigator, The Minerva Institute for Medical Research, Helsinki

1962-1990 Senior Investigator, The Minerva Institute for Medical Research, Helsinki

1959-1962 Resident, The Samfundet Folkhälsan Clinic for Teenagers, (22 months, part time), Helsinki, Finland

1963-1965 Resident, Internal Medicine, University of Helsinki, Finland

1965-1974 Senior Career Investigator, the Finnish National Research Council for Medical Sciences

(The Academy of Finland)

1965-1974 Docent of Medical Genetics, University of Helsinki, Finland

1966-1968 National Institutes of Health, International Postdoctoral Research Fellow at the Department of Medicine, laboratory of Dr. Paul A. Marks, Columbia University College of Physicians and Surgeons, New York (two years)

1973 Acting Professor of Medical Genetics, University of Helsinki, Finland (six months)

1974 Visiting Scientist, MRC Blood Group Unit (Drs. R.R. Race and R. Sanger) and MRCBiochemical Genetics Unit (Dr. E.B. Robson), London (3 months)

1981-1982 Visiting Scientist, Institut National de la Santé et de la Recherche Médicale, INSERM, Institut de Pathologie Moléculaire (Dr. J.C. Kaplan), Université Paris V (one year)(Recipient of Senior Scientist Award of the Academy of Finland)

1985-1995 Research Professor, the Academy of Finland

1986-1989 Visiting Professor, Department of Medicine and Institute of Human Genetics, Universityof Minnesota, Minneapolis, MN, USA

1989-1997 Visiting Professor, Roswell Park Cancer Institute, Buffalo, NY, USA

1995-1997 Research Professor, the University of Helsinki

Other Major Appointments, Finland

1. Medix Incorporated, vice chairman of the board and consultant 1965-1999

2. Central Medical Board of Finland, permanent consultant for genetics 1970-1996

3. Central Medical Board of Finland, member (genetics) 1976-1988

4. Väestöliitto, The Finnish Population and Family Welfare Federation, Department of Genetics, member 1975-1990

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Albert de la ChapelleCurriculum Vitae 5. The Sigrid Jusélius Foundation, Medical Board, secretary 1984-1988, member 1984-

1997, vice chairman 1995-1997)

6. The Finska Läkaresällskapet (Finnish Medical Society), member of board 1984-1986, president 1985, vice president 1986, member of grants committee 1981-1991, (chairman 1986-1991), honorary member 1996

Other Major Appointments, Finland Continued

7. Department of Gene Technology, University of Helsinki, member of the board 1983-

1986

8. Ministry of Education, member of working group to develop medical teaching in

Swedish, 1986

9. Academy of Finland, member of planning committee for a Finnish genome initiative,

1993-1994

10. Svenska Kulturfonden (Swedish Cultural Foundation of Finland), consultant 1995-1998

11. Samfundet Folkhälsan, Committee for the Genetics Clinic, chairman 1995-

12. Finnish National Board of Medicolegal Affairs, Permanent Member, 1996-2000

Military Activities

1954-1955 Served in Finnish Army as conscript (11 months). Promoted to Ensign 1955 (Anti-aircraft corps)

1955 Promoted to Lieutenant (Medical corps)

Awards and Honors, Finland

The J.W. Runeberg Prize for Research, The Finska Läkaresällskapet (The Finnish Medical Society), 1962

Member, Finska Vetenskapssocieteten (Finland's Senior Academy of Sciences and Letters), 1975

Corresponding member, Finnish Association of Dentists, 1978

Working member, Samfundet Folkhälsan, 1979

The E.J. Nyström Prize for Research, The Finska Vetenskapssocieteten (Finland's Senior Academy of Sciences and Letters), 1981

Commander of the Order of the Finnish Lion, 1984

150 Year Anniversary Prize for Research, The Finska Läkaresällskapet (The Finnish Medical Society), 1985

The Matti Äyräpää Prize for Medicine, Medical Society Duodecim, Finland, 1990

Commander of the Order of the White Rose of Finland, 1992

Honorary doctorate, University of Oulu, 1994

Corresponding member, The Dental Society, 1995

Honorary member, The Finska Läkaresällskapet (The Finnish Medical Society), 1996

Esko Nikkilä Lecturer, 1996

Fellow (“one of twelve") of the Academy of Finland, 1997

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Honorary member, Finland’s Senior Academy of Sciences and Letters, 1998

Honorary member, The Finnish Society of Medical Genetics, 1998

The Ossian Schauman Medal, Samfundat Folkhälsan, 2003

The Niilo Voipio Award, the Finnish Cancer Organizations, 2003

Awards and Honors, International

Member, European Society for Clinical Investigation, 1970

Jubilee Medal 1958 in Bronze with Diploma, Svenska Läkaresällskapet (The Swedish Society of Medicine), 1988

The Anders Jahre Prize for Medicine, University of Oslo, 1989

175 year Anniversary Commemorative Medal, Oslo University School of Medicine, 1989

Member, European Molecular Biology Organization (EMBO), 1989Awards and Honors, International Continued

Member, Royal Swedish Academy of Sciences, 1991

International Phoenix - Anni Verdi Award for Genetic Research (Italy) 1994

Honorary doctorate, University of Uppsala, 1995

Hamilton Fairley Award, European Society for Medical Oncology, 1996

Tim de Dombal Award and Lectureship, World Congress of Gastroenterology, 1998

European Society of Human Genetics Annual Award for Scientific Excellence (the Mauro Baschirotto Award), 2002

German Society of Human Genetics, GfH Medal of Honor, 2006

Awards and Honors, USAMember, Foreign associate, National Academy of Sciences, USA 1997

Simon M. Shubitz Award (University of Chicago), 1998

Wick R. Williams Memorial Award (Fox Chase Cancer Center), 1998

William Allan Award (American Society of Human Genetics), 2002

Fellow, American Association for the Advancement of Science, 2002

Highly Cited; Molecular Biology and Genetics, www.isihighlycited.com, 2003

Member, Association of American Physicians, 2005

Activities in International and National Bodies; Advisory Boards; Review Panels

European Society of Human Genetics, Board member, 1966-1995; Chairman of Aims and Statutes Committee, 1990-1991; President, 1993-1994

European Environmental Mutagen Society, councillor, 1974-1976

The Finnish Society of Medical Genetics, Founding member and first president, 1977-1980

The International Congress of Human Genetics, member of permanent committee, 1981-1986

The International Workshops on Chromosomes in Leukemia, member of advisory board, 1984-1990

The International Human Gene Mapping Workshops, executive committee, Chairman, 1983-1985; Member, 1985-1991

European School of Haematology, member of scientific committee, 1985-

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International Conferences on Prenatal Diagnosis & Therapy, member of advisory board 1986-1990

The Seventh International Congress of Human Genetics, Berlin, member of organizing committee,1986

The Ninth International Chromosome Conference, Marseille, member of scientific committee, 1986

Howard Hughes Medical Institute, member of ad hoc committee on Human Genome Mapping, 1986

Association des Cytogénéticiens de Langue Francaise, member, 1988-

The Eighth International Congress of Human Genetics, Washington, DC 1991, member of executive program committee, 1988-1991

The International Olympic Committee, member of Working Group on Gender Verification, 1988

The Tenth International Chromosome Conference, Uppsala 1989, member of organizing committee, 1989

Centre d'Etude du Polymorphisme Humain, Fondation Jean Dausset, Paris, collaborating investigator, 1990-

Activities in International and National Bodies; Advisory Boards; Review Panels Continued

Department of Medical Genetics, University of Uppsala, Sweden, member of Scientific Advisory Board, 1990-

Steering Committee of the Nordic Human Genome Project, Member, 1990-1997

The Human Genome Organization (HUGO), Member 1989-

Member, Gene Mapping Committee, 1991-1992

European Union, Member of Concerted Action on Genetic Studies in Cancer Families,1990-1997; Member of Concerted Action on Genetic Analysis of Epilepsy, 1992-1997; Member of Research Network on the Biological History of European Populations, 1994-

1997; Scientific Advisory Group on Human Genome Research, Member, 1994; BIOMED 2,

Grants Review Committee for Human Genome Research, Chairman (Rapporteur), 1995

Genome Interactive Databases, member of Editorial Committee, 1994-

European Commission Working Group on Cancer Research, Member, 1996

General Motors Mott Prize Selection Committee, 1997

The Wellcome Trust, member of the Genetics Advisory Group, 1997-

Reviewer of grants for various agencies and foundations in Finland, USA, Iceland, italy, France, Denmark, Canada, the Netherlands, Sweden, UK, Germany, New Zealand, 1997-

Faculty member, First Baltic Postgraduate Course in Medical Genetics, Vilnius, Lithuania, May 1997

Faculty member, Course on “Chromosome and Gene Alterations in Cancer” University of Helsinki, Nov 30-Dec 4, 1998

Reviewer, National Cancer Institute Site Visit, MIT, Cancer Center, Cambridge, MA, 1999

Primary reviewer for the appointment to a chair in Clinical Genetics, University of Uppsala, 1999-2000

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Primary reviewer of nominations to the Louis Jeantet Prize in Medicine, University of Geneva, Switzerland. Presentation of winner, Jean-Louis Mandel at Prize Ceremony, 1999

International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer, member of Council, 2000 –

International Cytogenetics and Genome Society, Founding member, 2002

Member, External Advisory Board, Cleveland G-I SPORE, 2003

Reviewer, Centres of Excellence Programme, Denmark, 2003

Member, Scientific Advisory Board, Genome Atlantic, Canada, 2004

Member, External Advisory Board, Case Western Reserve University Cancer Genetics Program, Comprehensive Cancer Center, 2006

Member, International Multidisciplinary Community Genetics Network, 2007

Co-Inventor on the following patents:

Title:Anhidrotic ectodermal dysplasia gene and method of detecting same. Approved 9/96

Title:Means for detecting familial colon cancer (FCC). Approved 2/96

Title:Diagnostic method employing MSH2 nucleic acids. Approved 12/97

Title:Human MSH2 protein. Approved 1/97

Title: Molecular cloning of the anhidrotic ectodermal dysplasia gene. Approved 12/97

Title: Diagnostic method employing MSH2 protein. Approved 11/98

Title: Method for diagnosis of ovarian dysgenesis. Approved 12/98

Co-Inventor on the following patents continued:Title: Tumor classification as indication of hereditary non-polyposis colorectal carcinoma.

Approved 2/99Title: BAALC protein isoforms, potential new markers for human acute leukemia and

hematopoietic and neuropoietic stem cells. Submitted 8/20/01Title: Cystatin B mutants. Approved 8/02Title: Identification and molecular characterization of FXGAG, fragile X site associated

gene: a novel gene associated with short stature. Submitted 6/02Title: Procedure for the detection of PMS2 specific mutations, Submitted 7/06

Editorships of Books

Chromosomes Today, Volume 6, (editors A de la Chapelle and M Sorsa) Elsewier/North Holland,

Amsterdam, pp 1-415, 1977

Human Gene Mapping 8, Karger, Basel, pp 1-823, 1985

Editorships of Journals

European Journal of Human Genetics, Associate Editor, 1991-Human Mutation, Communicating Editor, 1991-Blood Cells, Molecules & Diseases, Corresponding Editor, 1997-

Memberships of Editorial Boards

Acta Endocrinologica (Advisory Panel), 1965-1983Annales de Génétique, 1975-Cancer Genetics and Cytogenetics, 1980-1987Clinical Genetics, 2000-Community Genetics, 1997-2008

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Current Cancer Therapy Reviews, 2004-Cytogenetics and Cell Genetics, 1977-1983EMBO Journal, 1997-2002EMBO Reports, 2000-2002Encyclopedia of the Human Genome, 1999European Journal of Haematology, 1987-1994Excerpta Medica, Human Genetics, 1975-Familial Cancer, 1999-Finska Läkaresällskapets Handlingar, 1971-1980Genes, Chromosomes and Cancer, 1989-Genomics, 1987-Haematologica, 1999-Human Heredity, 1984-2005International Journal of Cancer, 1999-Journal of Clinical Oncology, 2006-Public Health Genomics Journal 2008-Scandinavian Journal of Haematology, 1976-1986

Reviewer for Journals in Addition to the Above

Acta Paediatrica Scandinavica Human Molecular GeneticsAmerican Journal of Human Genetics International Journal of AndrologyAmerican Journal of Medical Genetics International Journal of CancerAnnals of Clinical Research Journal of the American Medical AssociationAnnals of Human Genetics Journal of Clinical InvestigationBiochimie Journal of Clinical Oncology

Reviewer for Journals in Addition to the Above Continued

Biomedicine Journal of Internal MedicineBiotechniques Journal of Medical GeneticsBlood Journal of the National Cancer InstituteBritish Journal of Cancer LancetCancer Research Leukemia ResearchCarcinogenesis Molecular Medicine TodayCell Mutation ResearchChromosoma NatureClinical Cancer Research Nature GeneticsClinical Genetics Nature MedicineDisease Markers New England Journal of MedicineDuodecim OncogeneEuropean Journal of Cancer Scandinavian Journal of RheumatologyEuropean Journal of Pediatrics ScienceExperimental Cell Research Pediatric ResearchGene Reviews PLoS GeneticsHuman Genetics Proceedings of the National Academy of

Sciences, USA

Declared Eligible by the Appropriate Panels for

1968 Full Professorship in Medical Genetics, Faculty of Medicine, University of Oslo, Norway

1970 Associate Professorship in Genetics, Faculty of Sciences, University of Helsinki, Finland

1971 Full Professorship in Internal Medicine, University of Helsinki, Finland

1971 Full Professorship, in Medical Genetics, University of Århus, Denmark

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Albert de la ChapelleCurriculum Vitae1973 Associate Professorship in Chromosome Research, Faculty of Sciences, University of

Lund, Sweden

Acted As Official Opponent at Doctoral Dissertations

University of Helsinki, Finland:

1965 Dr. Pertti Aula: "Virus-Associated Chromosome Breakage"

1971 Dr. Jaakko Leisti: " Structural Variation in Human Mitotic Chromosomes"

1972 Dr. Svante Stenman: "Chromosome Pulverization Induced by Paramyxo-viruses"

University of Lund, Sweden:1970 Dr. Leif Håkansson: "On the Distribution of Proteins and Nucleic Acids along Human

Metaphase Chromosomes"

1979 Dr. Alf Hansson: "Association Between Human Acrocentric Chromosomes"

The Karolinska Institute, Stockholm, Sweden:

1989 Dr. Catharina Larsson: "Recessive Mutations in Tumorigenesis of Human Breast Carcinoma and Multiple Endocrine Neoplasia Type 1"

Acted As Official Opponent at Doctoral DissertationsUniversity of Oulu, Finland:

1990 Dr. Sirkka Liisa Hostikka: "Human Type IV Collagen. Characterization of the a-2(IV) Chain and the 3' End of Its Gene, and Identification of a Novel a-5(IV) Chain with Mutations in Alport Syndrome"

Supervisor of Doctoral CandidatesUniversity of Helsinki, Finland:

1970 Dr. Johan Edgren: "Effect of Cysteine on Chromosome Aberrations Induced by Radiation of Human Lymphocytes in vitro"

1971 Dr. Johan Wennström: "Effect of Ionizing Radiation on the Chromosomes in Meiotic and Mitotic Cells"

1974 Dr. Ritva-Kajsa Selander (Åbo Akademi): "Kromosomala makromolekylers effekt på vissa akridinderivats absorption och fluorescens"

1975 Dr. Jim Schröder: "Passage of Blood Cells Between Foetus and Mother"

1979 Dr. Olli Turunen: "Stimulation of Human Fetal, Cord Blood and Maternal Lymphocytes by Mitogenic Agents"

1980 Dr. Georg H. Borgström: "Clinical Implications of Chromosome Aberrations in Hematologic Neoplasia"

1981 Dr. Riitta Herva (University of Oulu): "Q and C Band Chromosomal Heteromorphisms in a Northern Finnish Population"

1984 Dr. Kalle Simola: "X-linked Mental Retardation with the Marker X Chromosome - A Clinical and Cytogenetic Study"

1988 Dr. Mauri Keinänen: "Lineage-Specific Chromosome Analysis of Hematopoietic Cells"

1989 Dr. Juha Kere: "Molecular Abnormalities of Chromosome 7 in Myeloid Disorders" (with honors)

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Albert de la ChapelleCurriculum Vitae1989 Dr. Anna-Elina Lehesjoki: "Hemophilia A: Molecular Studies in Finnish Families"

1990 Dr. Mikael Lindlöf: "Duchenne and Becker Muscular Dystrophy: DNA studies in Finnish families"

1991 Dr. Tiina Alitalo: "Gene Mapping of Juvenile Retinoschisis and Åland Island Eye Disease on the Human X Chromosome" and Molecular Study"

1991 Dr. Eeva-Marja Sankila: "Choroideremia: a Genetic and Molecular Study"

1991 Dr. Päivi Peltomäki: "Molecular Genetic Alterations in Human Testicular Cancer"

1992 Dr. Johanna Hästbacka: "In Search of the Diastrophic Dysplasia Gene. Genetic Mapping of the Disease Locus" (with honors)

1994 Dr. Lauri Aaltonen: "Molecular Genetic Background of Hereditary Nonpolyposis Colorectal Cancer" (with honors)

1994 Dr. Tuija Sulisalo: "Genetic Mapping of the Gene for Cartilage-Hair Hypoplasia"

1995 Dr. Pia Salo: "Molecular and Clinical Genetics of the Human Y Chromosome. Mapping of Three Genes"

1995 Dr. Esa Tahvanainen: "Mapping Genes of the Finnish Disease Heritage: Cohen syndrome, Northern epilepsy, and Cornea plana congenita"

1995 Dr. Minna Nyström-Lahti: "Genetic Predisposition to Hereditary Non-Polyposis Colorectal Cancer"

1996 Dr. Kristiina Aittomäki: "Genetics of Hereditary Ovarian Dysgenesis" (with honors)

1997 Dr. Pia Höglund: "Molecular Genetics of Congenital Chloride Diarrhea"

1998 Dr. Akseli Hemminki: “Inherited Predisposition to Gastrointestinal Cancer: the Molecular Backgrounds of Peutz-Jeghers Syndrome and Hereditary Non-polyposis Colorectal Cancer” (with honors)

1998 Dr. Kimmo Virtaneva: “The Molecular Genetics of Progressive Myoclonus Epilepsy: Positional Cloning of the Cystatin B Gene and Characterization of a Novel Minisatellite Expansion Mutation”

1999 Dr. Susanna Ranta: “Positional Cloning of the Progressive Epilepsy with Mental Retardation Gene (CLN8)” (with honors)

Supervisor of Doctoral CandidatesUniversity of Helsinki, Finland Continued:

2000 Dr. Stina Roth: "Molecular Genetic Background of Juvenile Polyposis"

2000 Dr. Maria Aminoff-Backlund: “Molecular Genetics of Selective Intestinal Malabsorption of Vitamin B12 The Gräsback-Imerslund Disease (Megaloblastic Anemia 1)”

2000 Dr. Kristiina Avela: “Positional Cloning of the Mulibrey Nanism Gene (MUL)”

2002 Dr. Anu-Liisa Moisio : “Predisposing and Modifying Genes in Hereditary Colorectal Cancer Syndromes ”

2002 Dr. Tarja Joensuu: “ Positional Cloning of the Usher Syndrome Type 3 Gene (USH3)”

2004 Dr. Juha Kolehmainen: ”Molecular Genetics of Cohen Syndrome”

2004 Dr. Reijo Salovaara: ”Molecular Pathology of Hereditary Colon Cancer”

Supervisor of Doctoral CandidatesThe Ohio State University

1997-2000 Dr. Robert Chadwick, “Discovery and Genetic Analysis of Genes Involved in Hereditary and Sporadic Colorectal Cancer”

1998-2002 Dr. Ying Huang, “The Genetics of Papillary Thyroid Cancer”

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Albert de la ChapelleCurriculum Vitae1998-2006 Dr. Heejei Yoon, “Molecular Genetics of Thyroid Cancer”

Supervisor of Postdoctoral Scientists

1975-1976 Janusz Limon, Ph.D., “Molecular basis of chromosome banding”

1977-1978 Bogdan Kaluzewski, M.D., “Human cytogenetics”

1990-1996 Anna-Elina Lehesjoki, M.D., Ph.D, “The genetics of epilepsy”

1991-1994 Päivi Peltomäki, M.D., Ph.D., “The genetics of colorectal cancer”

1992-1996 Eeva-Marja Sankila, M.D., Ph.D., “The genetics of eye disorders”

1994-1996 Lauri Aaltonen, M.D., Ph.D., “The genetics of colorectal cancer”

1994-2000 Maaret Ridanpää, Ph.D., “The molecular basis of cartilage hair hypoplasia”

1995-1996 Federico Canzian, Ph.D., “Microsatellite instability in human pathology”

1995-1997 Jose Luis Dieguez Lucena, M.D.,“The molecular genetics of the follicle-stimulating hormone receptor”

1995-1997 Ralf Krahe, Ph.D., “Genes predisposing to multifatorially determined human disease”

1996-1997 Antonio Percesepe, M.D., Ph.D, “Predisposition to colon cancer”

1996-2000 Katarina Pelin, Ph.D., “The genetics of muscle disorders”

1997-1999 Bru Cormand, Ph.D., “The molecular genetics of muscle disorders”

1998-2000 Natalia Pellegata, Ph.D., “The genetics of nasopharyngeal carcinoma”

1998-2005 Stephan Tanner, Ph.D., “The molecular basis of acute myeloid leukemia”

1999-2003 Hidewaki Nakagawa, M.D., Ph.D., “Loss of imprinting in colon cancer”

2001-2003 Claudia Baldus, M.D., "The molecular basis of acute leukemia"

2004-2007 Mark Clendenning, Ph.D., “The molecular basis of hereditary cancer”

2004-2007 Kaisa-Mari Sotamaa, M.D., “Modifier genes in colorectal cancer predisposition”

2005-2007 Christian Langer, M.D., “BAALC in leukemia”

2003-present Huiling He, Ph.D., (Research Scientist): “The molecular basis of papillary thyroid cancer”

2004-present Krystian Jazdzewski, Ph.D., ”Genes predisposing to thyroid cancer”

2006-present Laura Valle, Ph.D., “The genetics of colorectal cancer”

Supervisor of Postdoctoral Scientists

2008-present Jerneja Tomsic, Ph.D. “Genes in colorectal cancer predisposition”

Supervisor of Clinical Fellows, The Ohio State University

1999-2000 Darius Desai, M.D., “A recurrent de novo mutation in MSH2”

2000-2001 Emmanuel Zervos, M.D., “Genetic predisposition to pancreatic cancer”

2003-2005 Anjali Satoskar, M.D., “BAALC in neuropoiesis and hematopoiesis”

Supervisor of Undergraduate Students, with Honors, The Ohio State University

2003-2007 Kyle Walsh, BS “New haplotype and genealogical data give important implications for the origins and prevalence of the American founder mutatin of MSH2”. With distinction.

Organizer of International Conferences and Symposia

President, Sixth International Chromosome Conference, Helsinki, Finland, 1977

Co-organizer, First International Workshop on Chromosomes in Leukemia, Helsinki, Finland, 1977

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Albert de la ChapelleCurriculum VitaeHead of Organizing Committee, International Symposium on Clinical Genetics, Helsinki, Finland, 1977

President, Third Nordic Conference on Medical Genetics, Helsinki, Finland, 1984

Organizer, Eighth Human Gene Mapping Workshop, Helsinki, Finland, 1985

Co-organizer, Nobel Symposium on the Etiology of Human Disease at the DNA level, Björkborn, Sweden 1990

Organizer and Chairman, Research Conference on Inherited Disorders and Their Genes in Different European Populations, sponsored by the European Science Foundation, Eurovillage Obernai, France, 1993

Co-organizer, Research Conference on Inherited Disorders and Their Genes in Different European Populations, sponsored by the European Science Foundation, San Feliu de Guixols, Spain, 1995

Conference Committee, 14th EORTC-NCI-AACR Symposium on “Molecular Targets and Cancer Therapeutics”, Frankfurt, Germany, 2002

Memberships in Societies/Organizations

American Association for the Advancement of Science, 1984-

American Association for Cancer Research, 1997-

American Society Clinical Oncology, 2002-

American Society of Human Genetics, (corresponding member) 1966-

European Society of Human Genetics, 1966-

Finnish Association of Hematology, 1965-

Finnish Association of Internal Medicine, 1965-

Finnish Association of Medical Genetics, 1976-

Finska Läkaresällskapet, (Finland) 1953-

Finnish Medical Association, 1957-

Human Genome Organization (HUGO), 1989-

Societas Biochemica, Biophysica et Microbiologica Fenniae, (Finland) 1974-

Societas Genetica Fennica, (Finland) 1964-

Association of American Physicians, 2005-

Teaching ResponsibilitiesUniversity of Helsinki

1. Internal Medicine, 1963-19652. Medical Genetics, 1964-19743. Organized postdoctoral course in Human Genetics, 19684. As Professor and Chairman of Medical Genetics, responsible for pre- and postdoctoral

teaching and training, 1974-5. As Professor and Chairman of Medical Genetics responsible for teaching, training and

licensing in Clinical Genetics, 1982-6. Head of Graduate School in Medical Genetics, 1994-19977. Co-organized a postgraduate course on “Physical Mapping of Genes”, 1996

8. Co-organized a postgraduate course on “Linkage Disequilibrium in Human Gene Mapping”, 1997

9. Faculty member Course on “Chromosome and Gene Alterations in Cancer” University of Helsinki, Nov, 30-Dec. 4, 1998 (one lecture)

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Teaching Responsibilities Elsewhere

1. Nordic Course "Genetics in the Medical Curriculum", Århus, Denmark, 1970

2. WHO Training Course on the Diagnostic Techniques for Chromosome Aberrations, Stockholm, Sweden, 13.8-4.9., 1971

3. Population Biology, Faculty of Medicine, University of Turku, Finland, 19724. Scandinavian Summer School of Male Reproductive Biology, University of Turku,

Finland, June 5-17, 1972 and June, 19835. Genetics, Faculty of Medicine, University of Turku, Finland, 19756. Organized and led Postgraduate Course in Clinical Genetics, University of Helsinki,

Finland, 1976 7. Organized and led a Session on Cytogenetic Diagnostics in Acute Leukemia at

Symposium of the Nordic Cancer Union, Turku, Finland, 1976

8. Organized and led Postgraduate Course on Genetics of Common Disorders, Helsinki, Finland, 1979

9. EMBO Course on the Chromosomal Localization of Genes, Paris, France, 1982 and 198310. American Society of Clinical Oncology, Educational Workshop, Toronto, Ontario, Canada,

May, 198411. Advanced Course in Human Genetics, University of Minnesota, Minneapolis, MN, USA,

1986, 1987, 1988

12. Faculty member, European School of Medical Genetics, Sestri Levante (Genova), Italy, April 6-12,1988 (several lectures)

13. Co-organized Course on Cytogenetics and Molecular Genetics in Haematological Malignancy, European School of Haematology, Chateau de Maffliers, France, April 18-22, 1988

14. Co-organized International Symposium "Exploring the Human Genome", Helsinki, Finland, November 21, 1988

15. Faculty member, European School of Medical Genetics, Sestri Levante (Genova) Italy, April 1-7, 1990 (several lectures)

16. Faculty member, European School of Medical Genetics, Sestri Levante (Genova) Italy, April 5-8, 1992 (two lectures)

17. Faculty member, Course on "Mechanisms of Sex Determination and Intersexuality. Basic and ClinicalAspects" in Buenos Aires, Argentina, October 6, 1992 (2 lectures)

18. "Star Lecturer", Short Course in Medical and Experimental Mammalian Genetics, Bar Harbor, ME, USA, July 1995 (two lectures)

19. Faculty member, First Baltic Postgraduate Course in Medical Genetics, Vilnius, Lithuania, May 1997, (two lectures)

20. Examiner, Habilitation, Université Louis Pasteur, Strasbourg for Dr. Stanislas du Manoir, “Analyse des aberrations chromosmiques and de leurs conséquences transcriptionnelles dans les tumeurs malignes par cytogénétique moléculaire et puces d’ADN”, May 28, 2002

Teaching ResponsibilitiesOhio State University 1997 - present

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1. Faculty Member, Dept. of Molecular Virology, Immunology and Medical Genetics course 734, Human Cancer Genetics, 2000 -

2. Faculty Member, Integrated Biomedical Science Graduate Program, Molecular Genetics 880.06, Module 2, Genes and Genome Organization, 2000 -

Major Courses Attended

1. Course in Human Cytogenetics. MRC Clinical Effects of Radiation Research Group, Edinburgh, Scotland, 1960

2. Gordon Research Conference on Cell Structure and Metabolism, Meriden, New Hampshire, USA 1967

3. Short Course in Genetics (organized by The Johns Hopkins University and The Jackson Laboratory), Bar Harbor, Maine, USA 1968

4. Workshop on Morphogenetic Tissue Interactions, Helsinki, Finland, 1969

5. Gordon Research Conference on Developmental Biology, Andover, New Hampshire, USA 1970

6. EMBO Summer School on The Separation of Macromolecules and Particles, Uppsala, Sweden, 1971

7. Postgraduate Course on Gene Technology, The Pasteur Institute, Paris, France, March-April 1982

Discontinued in 1982

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Albert de la ChapelleCurriculum VitaeMajor Invited Talks

1. Department of Medical Genetics, University of Uppsala, Sweden, 1960 Seminar: "Satellite Association of Human Acrocentric Chromosomes." (in Swedish)

2. Conference of the Nordic Society of Clinical Pathologists, Savonlinna, Finland, 1961Lecture: "Study on Human Chromosomes." (in Swedish)

3. Nordic Conference on Clinical Cytogenetics, Uppsala, Sweden, 1961Lecture: "Cytogenetics of Turner's Syndrome." (in Swedish)

4. Conference of the Nordic Society of Internists, Lund, Sweden, 1962 Lecture: "Chromosomes in Inborn Errors of Metabolism." (in Swedish)

5. Ninth Congress of the European Society of Haematology, Lisbon, Portugal, 1963Lecture: "Factors Stimulating Cell Division in Cultures Leucocytes. Chemical, Serological and Immunological Studies on Mitogens."

6. Third Conference of the Nordic Society of Geneticists, Helsinki, Finland, 1964 Lecture: "Isochromosomes for the Long Arm of the Human X Chromosome." (in Swedish)

7. Meeting of the Nordic Fertility Club, Lund, Sweden, 1966Lecture: "Males with Female Chromosomes." (in Swedish)

8. Symposium on the Labelling of Mammalian Chromosomes, Manchester, England, 1966 Lecture: "Isochromosome-X in Man."

9. Department of Pathology, Dartmouth College School of Medicine, Hanover, New Hampshire, USA, 1967Lecture: "Males with Female Chromosomes."

10. Department of Pathology, University of Colorado, Denver, Colorado, USA, 1967 Lecture: "Males with XX Sex Chromosomes."

11. Department of Biology, City of Hope Medical Center, Duarte, California, USA, 1967 Lecture: "Males with Female Chromosomes."

12. Department of Biology, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA, 1968 Lecture: "Differentiation of Erythroid Cells."

13. Laboratorio di Radiobiologia, CNEN, Rome, Italy, 1970Lecture: "Erythroid Cell Specialization: DNA-RNA Hybridization Experiments."

14. Symposium of the European Society of Human Genetics, "Determination and Differentiation of Sex, Ghent, Belgium, 1970Lecture: "The Development of Testes in the Apparent Absence of Y Chromosome Material."

15. Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA, 1970

Lecture: "Transcription in Differentiating Fetal Erythroid Cells."

16. Department of Terrestrial Magnetism, The Carnegie Institute of Washington, Washington, DC, USA, 1970Lecture: "The Control of Differentiation in Erythroid Cells."

17. Institute of Human Genetics, University of Hamburg, Germany, 1971Lecture: "Glutathione Reductase and other Enzyme Activities in Haematological Disorders Associated with C Trisomy."

18. Department of Pediatrics, University of Hamburg, Germany, 1971 Lecture: "The Control of Differentiation in Erythroid Cells."

19. Max-Planck Institute for Experimental Medicine, Göttingen, Germany, 1971 Lecture: "Erythroid Cell Specialization: DNA-RNA Hybridization Experiments."

20. International Symposium on The Synthesis, Structure and Function of Hemoglobin. Bad Nauheim, Germany, 1971Lecture: "Molecular Control of Differentiation: DNA, RNA and Haemoglobin Synthesis in the Erythroid Cells of Fetal Mice."

14

Albert de la ChapelleCurriculum VitaeMajor Invited Talks Continued

21. Institute of Anthropology and Human Genetics, University of Heidelberg, Heidelberg, Germany, 1971 Lecture: "The Etiology of Human XX Males."

22. Nobel Symposium No 23. Chromosome Identification -- Techniques and Applications in Biology and Medicine, Stockholm, Sweden, 1972Lecture: "Cytogenetical and Clinical Aspects of Trisomy-8 in the Bone Marrow."

23. Nobel Symposium No. 23. Chromosome Identification -- Techniques and Applications in Biology and Medicine, Stockholm, Sweden, 1972Lecture: "Sequential Denaturation and Reassociation of Chromosomal DNA in situ."

24. Norsk Hydro's Institute for Cancer Research, Oslo, Norway, December 18, 1972 Lecture: "What is the Basis of Chromosome Banding." (in Swedish)

25. Institute of Medical Genetics, University of Oslo, Norway, December 20, 1972 Lecture: "Immunological Interaction Between Mother and Child." (in Swedish)

26. Meeting of the Nordic Society of Haematology, Helsinki, Finland, June 1, 1973Lecture: "The Significance of Chromosome Investigations in the Diagnosis of Malignant Hematologic Diseases." (in Swedish)

27. Institute of Genetics, University of Glasgow, Scotland, April 29, 1974 Lecture: "Pericentric Inversions in Human Chromosomes 9 and 10."

28. Department of Genetics, University of Aberdeen, Scotland, May 3, 1974 Lecture: "Human Chromosome Polymorphisms."

29. Inaugural Lecture as First Holder of Chair in Medical Genetics, University of Helsinki, Finland, October 23, 1974Lecture: "Human Genetics Today." (in Finnish)

30. European Congress of Rheumatology, Helsinki, June 3, 1975Lecture: "Biological Hazards of Radiation."

31. First International Clinical Genetics Seminar, Athens, Greece, May 5, 1976 Lecture: "The Clinical Importance of Human Chromosomal Polymorphisms."

32. Symposium of the European Society of Human Genetics, Athens, Greece, May 8, 1976 Lecture: "Pericentric Inversions in Human C Group Chromosomes."

33. Fifth International Congress of Human Genetics, Mexico City, Mexico, October 11, 1976 Lecture: "The Etiology of XX Males."

34. International Symposium on Clinical Genetics, Helsinki, Finland, January 3, 1977 "Opening Address."

35. International Symposium on Clinical Genetics, Helsinki, Finland, January 4, 1977 Lecture: "Clinical Consequences of Human Pericentric Inversions."

36. Sixth International Chromosome Conference, Helsinki, Finland, August 29, 1977 "Opening Address."

37. Working Conference on Preventable Aspects of Genetic Morbidity, Cairo, Egypt, April 1, 1978Lecture: "The Occurrence and Prevention of Unbalanced Offspring in Carriers of Reciprocal Translocations."

38. Working Conference on Preventable Aspects of Genetic Morbidity, Cairo, Egypt, April 3, 1978Lecture: "Nucleated Fetal Cells Circulating in the Maternal Blood. An Alternative Approach to Prenatal Diagnosis."

39. Third European Conference on Prenatal Diagnosis of Genetic Disorders, Munich, Germany, April 13, 1978Lecture: "Fetal Blood Sampling and Other Alternative Methods."

40. Institute of Endocrinology, The Medical Academy of Lódz, Poland, May 16, 1979 Lecture: "Males with the Karyotype 46,XX."

15


41. Fourth Polish Cytogenetics Conference, Gdánsk, Poland, May 18, 1979 Lecture: "Human Chromosomal Inversions."

Major Invited Talks Continued

42. Nordic Research Course on Environmental Genetics, Helsinki, Finland, May 23, 1979 Lecture: "Aspects of Mutagenicity and Legislation."

43. Fifth International Workshop on Human Gene Mapping, Edinburgh, Scotland, July 13, 1979 Presentation: "The Map of the Human Y Chromosome."

44. European Society of Human Genetics Symposium on Genetic Aspects of Infertility and Foetal Wastage, Southampton, England, July 20, 1979Lecture: "The Etiology of XX Males."

45. Meeting of the Nordic Society of Hematology, Ålborg, Denmark, May 20, 1980 Lecture: "Chromosome Aberrations in Acute Lymphatic Leukemia." (in Swedish)

46. Symposium of the European Society of Human Genetics, Dubrovnik, Yugoslavia, October 6, 1980 Lecture: "The Map of the Human X Chromosome."

47. Kroc Foundation Symposium on Sex Determination, Santa Ynez, California, USA, December 11, 1980 Lecture: "The Etiology of Maleness in XX Men."

48. Department of Medicine, University of Chicago, Illinois, December 15, 1980 Lecture: "Human Gene Mapping by Gene Dosage."

49. Division of Medical Oncology, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, December 16, 1980Lecture: "Human Gene Mapping by Gene Dosage."

50. Symposium of the European Society of Human Genetics, Zürich, Switzerland, March 28, 1981 "Concluding Remarks of the Symposium."

51. Meeting of the Nordic Society of Hematology, Helsinki, Finland, May 15, 1981 Lecture: "Chromosome Aberrations in Acute Lymphatic Leukaemia." (in Swedish)

52. Sixth International Congress of Human Genetics, Jerusalem, Israel, September 15, 1981 Lecture: "Chromosomes in Human Leukemia: Experience of the First Three Workshops."

53. Sixth International Congress of Human Genetics, Jerusalem, Israel, September 15, 1981 Lecture: "Delivery of Genetic Services: Transition from Research to Routine."

54. Serono Symposium on The Genetic Control of Gamete Production and Function. Vienna, Austria, October 12, 1981Lecture: "The Map of the Human X Chromosome."

55. Institute of Molecular Pathology, University Paris V, France, December 17, 1981 Lecture: "XX Males." (in French)

56. Department of Pediatrics, University of Strasbourg, France, January 26, 1982 Lecture: "XX Males." (in French)

57. Department of Human Genetics, University of Utah, Salt Lake City, Utah, March 8, 1982 Lecture: "The Origin of XX Males."

58. Meeting on Recent Progress in the Genetic Analysis of the X Chromosome, Department of Human Genetics, University of Oxford, England, April 27, 1982Lecture: "Genetics of Sexual Dysgenesis."

59. Department of Pediatrics, University of Marseille, France, May 6, 1982Lecture: "The Origin of XX Males." (in French)

60. International Agency for Cancer Research, Lyon, France, May 17, 1982 Lecture: "The Origin of XX Males." (in French)

61. Symposium of the European Society of Human Genetics, Madrid, Spain, October 1, 1982 Lecture: "On the Mechanisms of Origin of XX Males and X Males."

62. Human Genetics Society, Melbourne, Australia, February 22, 1983 Lecture: The Etiology of XX Males."

16



63. Department of Medicine, Flinders Medical Center, South Australia, February 23, 1983Lecture: "Chromosomal Mechanisms in Human Leukaemia."

64. Genetics Department, University of Adelaide, Australia, February 24, 1983Lecture: "The Cytogenetics of Human Lymphoma and the Localization of the Breakpoints of Chromosomes in Burkitt's Lymphoma by in situ Hybridization of Cloned Immunoglobulin Genes."

65. Grand Rounds, Adelaide Children's Hospital, Adelaide, Australia, February 28, 1983 Lecture: "Chromosomal Mechanisms in Leukemia."

66. Department of Medicine, Queen Elizabeth Hospital, Adelaide, Australia, March 2, 1983 Lecture: "Etiology of Maleness in XX Males."

67. South Australia Genetics Group, University of Adelaide, Australia, March 2, 1983 Lecture: "Chromosomal Localization of Single-Copy Genes by in situ Hybridization."

68. Grand Rounds, Queen Elizabeth Hospital, University of Adelaide, Australia, March 3, 1983 Lecture: "Chromosomal Mechanisms in Human Leukemia."

69. Serono Symposium on the Differentiation of Sex, Carmel, California, USA, March 17, 1983 Lecture: "The Etiology of XX Males."

70. Second Nordic Conference of Medical Genetics, Copenhagen, Denmark, May 8, 1983 Lecture: "DNA Technology in the Diagnosis of Hereditary Disorders." (in Swedish)

71. Eighth International Chromosome Conference, Lübeck, Germany, September 22, 1983Lecture: "Localization of Single-Copy DNA Sequences on Human Chromosomes by in situ Hybridization."

72. Eighteenth Meeting of the German Society of Anthropology and Human Genetics, Münster, Germany, October 7, 1983Lecture: "The Human X Chromosome."

73. Third Nordic Conference of Medical Genetics, Helsinki, Finland, January 18, 1984 "Opening Address."

74. Department of Haematology, South African Institute for Medical Research, University of the Witwatersrand, Johannesburg, South Africa, March 14, 1984Lecture: "The Aetiologic Role of Chromosome Abnormalities in Neoplasia."

75. Department of Human Genetics, South African Institute for Medical Research, University of the Witwatersrand, Johannesburg, South Africa, March 14, 1984Lecture: "The Localization of Single-Copy DNA Sequences on Human Chromosomes by in situ Hybridization."

76. Department of Human Genetics, South African Institute for Medical Research, University of the Witwatersrand, Johannesburg, South Africa, March 15, 1984Lecture: "The Aetiology of Maleness in XX Males."

77. Department of Human Genetics, Cape Town Medical School, South Africa, March 20, 1984 Lecture: "The Aetiology of Maleness in XX Males."

78. Department of Cytogenetics, Tygerberg Medical School, Stellenbosch University, Tygerberg, South Africa, March 23, 1984Lecture: "The Etiology of Maleness in XX Males."

79. American Society of Clinical Oncology, Educational Workshop, Toronto, Ontario, Canada, May, 1984 Lecture: "The Etiologic Role of Chromosome Abnormalities in Neoplasia."

80. Center for Cancer Research and The Whitehead Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA, May 10, 1984Lecture: "The Etiology of Maleness in Human XX Males."


81. Second International Conference on Malignant Lymphoma, Lugano, Switzerland, June 14, 1984 Lecture: "The Chromosomes in Burkitt's Lymphoma."


82. Eighth International Congress of Histochemistry and Cytochemistry, Helsinki, Finland, August 6, 1984 Lecture: "The Localization of Single-Copy Genes by in situ Hybridization.

83. Conference on Medical Genetics, Past, Present and Future, Oslo, Norway, August 24, 1984 Lecture: "Chromosomal Mechanisms in Human Neoplasia."

84. Conférence INSERM: Structure moléculaire du chromosome Y, relation avec le chromosome X, sa fonction dans la détérmination du sexe chez l'homme normal et en pathologie, Seillac, France, September 27, 1984Lecture: "Males Without a Y Chromosome: Basic Facts and Recent Evidence."

85. Conférence INSERM: Structure moléculaire du chromosome Y, relation avec le chromosome X, sa fonction dans la détérmination du sexe chez l'homme normal et en pathologie, Seillac, France, September 27, 1984Lecture: "Concluding Remarks of Conference."

86. Symposium on Myelodysplastic Syndromes, Helsinki, Finland, January 11, 1985 Lecture: "Chromosomal Mechanisms in Neoplasia."

87. Department of Clinical Genetics, Karolinska Hospital, Stockholm, Sweden, January 14th, 1985Lecture: "Chromosomal Mechanisms in Neoplasia."

88. Seventh Steno Symposium, Hagedorn Research Laboratory and Steno Memorial Hospital, Gentofte, Denmark, May 13, 1985Lecture: "Genes Involved in Human Sex Determination and Differentiation."

89. Fourth International Clinical Genetics Seminar "Endocrine Genetics and Genetics of Growth", Athens, Greece, May 21, 1985

90. Third European Conference on Clinical Oncology and Cancer Nursing, Stockholm, Sweden, June 18, 1985Lecture: "Tumor Cytogenetics."

91. Eleventh World Congress of Gynecology and Obstetrics, Berlin, West Germany, September 18, 1985 Lecture: "DNA Technology in Prenatal Diagnosis."

92. Second International Amateur Athletics Federation Medical Congress, Canberra, Australia, October 2, 1985Lecture: "The Use and Misuse of Sex Chromatin Screening for "Gender Identification" of Female Athletes."

93. Fourth Nordic Conference on Medical Genetics, Oslo, Norway, January 25, 1986 Lecture: "The Masculinizing Gene." (in Swedish)

94. Institute of Human Genetics, University of Minnesota, Minneapolis, MN, USA, April 10, 1986 Lecture: "The Testis Determining Gene."

95. Cold Spring Harbor Symposium on the Molecular Biology of Homo Sapiens, Cold Spring Harbor, New York, USA, May 29, 1986Lecture: "Genetic and Molecular Studies on 46,XX and 45,X Males."

96. Marseille Chromosome Conference. Ninth International Chromosome Conference, Marseille, France, June 20, 1986Lecture: "Males Without a Y Chromosome: Recent Progress."

97. Seventh International Congress of Human Genetics, Berlin, Germany, September 25, 1986.Lecture: "Cytogenetics is as Useful as Ever in the Study of Human Disease."

18


98. Symposium on Molecular Genetics and Cytogenetics of Human Neoplasia, Berlin, Germany, September 27, 1986Lecture: "Morphological, Immunological and Molecular Characterization of Bone Marrow Mitoses."

99. National Cancer Institute, Frederick Cancer Center, Frederick, Maryland, USA, October 7, 1986 Lecture: "Morphological, Immunological and Molecular Characterization of Bone Marrow Mitoses."


`100. National Institutes of Health, Clinical Genetics Program, Bethesda, Maryland, USA, October 8, 1986 Lecture: "Testis Determination in Man."

101. National Institute of Child Health and Human Development, Center for Population Research. Workshop on Genetic Markers of Sex Differentiation, Bethesda, Maryland, USA, October 10, 1986Lecture: "The Etiology of Maleness in 45,X, 46,XX and 47,XXX Males."

102. International Symposium "From Man to Gene From Gene to Man", Florence, Italy, November 3, 1986Lecture: "The Genetics of Sex Determination in Man."

103. The Royal College of Physicians of London, Conference on New Prospects in Genetic Diseases, London, England, December 4, 1986Lecture: "The Molecular Biology of the Human X Chromosome."

104. British Society for Developmental Biology, Symposium on "The Mammalian Y Chromosome: The Molecular Search for the Sex Determining Gene", Oxford, England, March 25, 1987Lecture: "Genes on the Human Y Chromosome."

105. European Federation of Child Neurology Societies Meeting, Hyvinkää, Finland, June 15, 1987 Lecture: "The Molecular Biology of Duchenne Muscular Dystrophy."

106. International Conference on the New Genetics and the Human Gene Map, Paris, France, September 12, 1987Lecture: "Abnormal Sex Determination in Man."

107. 100th Anniversary of the US National Institutes of Health, Celebration at the University of Helsinki, Finland, September, 1987Lecture: The Molecular Biology of Primary Sex Determination in Man."

108. Department of Human Genetics, University of Manitoba, Winnipeg, Manitoba, Canada, October 28, 1987Lecture: "The Genetics of Primary Sex Determination in Man."

109. The Faculties of Medicine and of Physical Education and Recreation Studies, University of Winnipeg, Manitoba, Canada, October 29, 1987Lecture: "Sex Testing in the Olympics."

110. Department of Neurology, Duke University, Durham, N.C., USA, December 9, 1987 Lecture: "The Molecular Genetics of Primary Sex Determination in Man."

111. International Symposium on "Molecular Genetics and Isolated Populations", Helsinki, Finland, January 7, 1988Lecture: "X- and Y-chromosomal Polymorphisms in the Search for the Testis Determining Factor."

112. National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA, March 15, 1988Lecture: "Recent Developments in the Molecular Biology of the Y Chromosome."

113. Roswell Park Memorial Institute, Buffalo, New York, USA, March 25, 1988 Lecture: "The Genetics of Primary Sex Determination in Man."

114. Fourth International Symposium of the Belgian Society for Clinical Chemistry, Brugge, Belgium, May 26, 1988

19


Opening lecture: "General Introduction to Recombinant DNA Technology in Diagnosis."

115. Fifth Nordic Meeting of Medical Genetics, Laugarvatn, Iceland, August 27, 1988 Lecture: "Clinical Genetics in Finland." (in Swedish)

116. International Symposium on the Impact of Medical Genetics on Public Health, Copenhagen, Denmark, October 29, 1988Lecture: "Impact of Molecular Genetics on the Understanding of Sex Determination and its Abnormalities in Man."


117. 13th Congress of the European Society of Medical Oncology, Lugano, Switzerland, October 30, 1988Lecture: "Present Impact of Cytogenetics and Molecular Genetics on the Management of Hematologic Malignancies."

118.Department of Medical Genetics, Biomedical Center, University of Uppsala, Sweden, November 28, 1988

Lecture: "The Molecular Genetics of Primary Sex Determination in Man."

119.Department of Clinical Genetics, the Karolinska Hospital, Stockholm, Sweden, November 29, 1988Lecture: "Primary Sex Determination in Man." (in Swedish)

120.The Swedish Society of Medicine, Stockholm, Sweden, November 30, 1988 Lecture: "The Molecular Basis of Human Sex Determination and Its Abnormalities." (in Swedish)

121. Third International Workshop on Chromosomes in Solid Tumors, Tucson, Arizona, USA, February 28, 1989Lecture: "Conference Overview."

122. Berzelius Symposium XVIII: Molecular Genetics and Human Disease, Uppsala, Sweden, September 19, 1989Lecture: "Sex determination."

123. University of Oslo School of Medicine, Oslo, Norway, September 29, 1989 Lecture: "The Molecular Genetics of Sex Determination." (in Swedish)

124. 28th Reunion of the French Society for the Study of Fertility, Paris, France, October 19, 1989

Lecture: "Human Sex Reversal." (in French)

125.International Symposium on the Molecular Genetics of Sex Determination, New Orleans, LA, USA, April 30, 1990

Lecture: "XX Males and XX true Hermaphrodites."

125.VII World Congress on Human Reproduction, Helsinki, Finland, June 28, 1990 Lecture: "The Genetics of Testis Determination."

127.Royal College of Pathologists of Australasia and the Haematology Society of Australia, Christchurch, New Zealand, October 3, 1990

Lecture: "Clinical Utility of Molecular Diagnostics and Cytogenetics in Leukemia."

128.Third Hematology Update Symposium of the Puerto Rican Society of Hematology, San Juan, Puerto Rico, October 12-14, 1990

Lecture: "Introduction to Cytogenetics and Molecular Diagnostics for the Hematologist."Lecture: "The Use of Molecular Diagnostics in Leukemia/Lymphoma."

129.RP Foundation Fighting Blindness Workshop on Progress in Genetic Studies on Retinal Degeneration, Cincinnati, Ohio, USA, October 16, 1990

Lecture: "Localization of Åland Island Eye Disease Locus by Linkage Analysis."

20

Albert de la ChapelleCurriculum Vitae130. International Athletic Foundation Workshop on the Approved Methods of Gender

Verification, Monte Carlo, Monaco, November 10, 1990

Lecture: "Why Sex Chromatin Screening should be Abandoned as a Method for Gender Verification."

131. Center for Genetics in Medicine, Washington University School of Medicine, St. Louis, Missouri, USA, April 26, 1991Lecture: "Population variation in human genetic disease: the example of Finland."

132. Colorectal Cancer Workshop, National Cancer Institute, Baltimore Maryland, USA, May 1, 1991 Lecture: "Linkage Studies in Hereditary Colorectal Cancer."

133. First Nordic Genome Workshop, Visby, Sweden, May 16, 1991 Lecture: "Population Genetics of Inherited Disorders in Isolated Populations."

134. Nordic Cancer Union, Symposium on Genetics of Cancer, Åbo, Finland, September 20, 1991

Lecture: "Familial Cancer Syndromes."


135.Howard Hughes Medical Institute, Workshop on the Causes and Consequences of Chromosome Rearrangements in Human Leukemia and Lymphoma, Bethesda, Maryland, USA, October 6, 1991

Lecture: "Chromosome 7 in Myeloid Leukemia."

136.Istituto Giannina Gaslini, Genova, Italy, January 10, 1992Lecture: "Sex Determination and Sex Chromosome Abnormalities."

137. European Society of Human Genetics, 24th Annual Meeting, Elsinore, Denmark, May 27-31, 1992 Lecture: " Inherited Diseases in Genetic Isolates."

138. 1st Nordic HUGO Workshop on Genetic Mapping, Aarhus, Denmark, September 21-23, 1992 Lecture: "Linkage Disequilibrium Mapping in Isolated Populations".

139. Endocrinological Research Center, Buenos Aires, Argentina, October 7, 1992 Lecture: "Males Without a Y Chromosme."

140. National Cujo University, Mendoza, Argentina, October 9, 1992 Lecture: "Males Without a Y Chromosome."

141. Whitehead Institute, Cambridge, MA, March 25 1993Lecture: "The Study of Hereditary Disorders in Isolated Populations."

142. XXVI Nordic Meeting of Gastroenterology, Tampere, Finland, May 27, 1993 Lecture: Lecture: "Genetics of Hereditary Non-polyposis Colorectal Carcinoma."

143. Japanese Digestive Disease Week, Kobe, Japan, September 22, 1993 Lecture: "The Hereditary Component of Colorectal Cancer."

144. Sixth Tokyo Symposium for Colorectal Surgery, Tokyo, September 25, 1993 Lecture: "The Hereditary Component of Colorectal Cancer."

145. European Concerted Action on Genetic Analysis of Epilepsy, Montpellier, France, November 5, 1993 Lecture: "A New Autosomal Recessive Childhood Epilepsy."

146. European Research Conference on Inherited Disorders and Their Genes in Different European Populations, Obernai, France, November 27, 1993Lecture: "Linkage Disequilibrium in Mapping and Cloning of Recessively Inherited Disease Genes."

147. Institute of Medical Genetics, Oslo, Norway, December 13, 1993Lecture: "The Genetics of Colorectal Cancer." (in Swedish)

148. Roswell Park Cancer Institute, Buffalo, NY, January 7, 1994Medical Grand Rounds Lecture: "Hereditary Colorectal Cancer."

21

Albert de la ChapelleCurriculum Vitae149. Cancer Progress 1994 Conference, New York, NY, February 28, 1994 Lecture:

"Hereditary Colon Cancer”. March of Dimes 25th Clinical Genetics Conference, Orlando, FL, March 15, 1994 Lecture: “The Genetics of Colorectal Cancer.”

150. American College of Medical Genetics, First Conference, Orlando, FL, March 16, 1994 Lecture: “Heredity in Nonpolyposis Colorectal and Related Human Cancers.”

151. Fourth European Workshop on Cytogenetics and Molecular Genetics of Human Solid Tumors, Noordwijkerhout, April 23, 1994Lecture: “The Genetics of Colorectal Cancer.”

153. National Cancer Institute and National Center for Human Genome Research Workshop on Hereditary Breast, Ovarian and Colon Cancer, Washington DC, April 27, 1994Lecture: “Molecular Epidemiology of Colon Cancer.”

152. Cancer and Leukemia Group B, 1994 Spring meeting, Washington DC, April 30, 1994Lecture: “Hereditary Colon Cancer.”

155. International Genetic Epidemiology Society, Paris, June 1, 1994Lecture: "Genetics of Colon Cancer."

156. United European Gastroenterology Week, Oslo, Norway, June 26, 1994Lecture: "Recent Advances in GI Cancer Genetics."


157. Fourth Workshop of the Nordic Genome Initiative, Helsinki, Finland, September 4, 1994 Lecture: "The Molecular Epidemiology of Hereditary Colon Cancer."

158. International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer, Milan, Italy, September 11, 1994

Lecture: "Future Perspectives."

159. Societas Biochemica Biophysica et Microbiologica Fenniae, Biosciences Conference, Helsinki, Finland, September 16, 1994Lecture: "Predictive Testing in Hereditary Colon Cancer."

160. Italian Federation of Human Genetics (FISME), Ninth Annual Conference, Spoleto, Italy, September 28, 1994Lecture: "Hereditary Colon Cancer."

161. American Society of Human Genetics, 44th Annual Meeting, Montreal, Canada, October 19, 1994Lecture: "Dominant Mutator Model: Hereditary Non-polyposis Colon Cancer: Clinical and Phenotypic Effects."

162. Genes and Diseases, San Raffaelle International Biomedical Science Park, Telethon Italy, Milano, Italy, November 11, 1994Lecture: "Linkage Disequilibrium in Isolated Populations as a Tool in the Positional Cloning of Disease Genes: the Example of Finland."

163. Sloan-Kettering Memorial Cancer Center, New York, NY, November 16, 1994 Lecture: "The Role of Mismatch Repair Genes in Hereditary Colon Cancer."

164. First Annual Symposium on Human Molecular Genetics, University of Antwerp, Antwerp, Belgium, November 26, 1994Lecture: "Hereditary Colon Cancer."

165. EUROFAP, EC Concerted Action: Genetic Studies in Cancer Families, Genetics of FAP and HNPCC, Budapest, Hungary, December 3, 1994Lecture: " Spectrum of HNPCC Mutations."

166. IKA (the Comprehensive Cancer Centre Amsterdam) 15th Anniversary International Congress on Colorectal Cancer: from Gene to Cure, University of Amsterdam, Amsterdam, February 9, 1995Lecture: "Epidemiology of Inherited Susceptibility to Colorectal Cancer."

22

Albert de la ChapelleCurriculum Vitae167. IKA (the Comprehensive Cancer Centre Amsterdam) 15th Anniversary International

Congress on Colorectal Cancer: from Gene to Cure, University of Amsterdam, Amsterdam, February 9, 1995Lecture: "DNA Mismatch Repair Genes in the Causation of Colorectal Cancer."

168. 400-Year Anniversary Jubilee Symposium on Cancer - from Molecular Mechanisms to Clinical Therapy, University of Uppsala, Uppsala, Sweden, March 23, 1995Lecture: "Genetic Mechanisms in Hereditary Colon Cancer."

169. Workshop on Genetic Screening for Colorectal Cancer, National Cancer Institute, Bethesda, MD, April 10, 1995Lecture: "A Population-Based Study to Determine the Incidence of HNPCC."

170. European Society of Human Genetics, 27th Annual Meeting, Berlin, Germany, May 25, 1995Lecture: "Hereditary Colorectal Cancer."

171. IIIrd KTL-Symposium on Molecular Mechanisms of Disease, Espoo, Finland, May 29, 1995 Lecture: "Inherited Predisposition to Colon Cancer and Associated Cancers"

172. International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer, Helsinki, Finland, September 15, 1995Lecture: "Molecular Genetics in Epidemiological Evaluation of HNPCC."

173. Fifth International Congress on Hormones and Cancer, Quebec, Canada, September 19, 1995:Lecture: "Genetic Instability and Cancer."


174. Fifth International Congress on Hormones and Cancer, Quebec, Canada, September 19, 1995:Lecture: "Genetic Instability and Cancer."

175. American Association for Cancer Research, Special Conference entitled "Cancer: The Interface Between Basic and Applied Research", Baltimore, Nov 6, 1995 Lecture: "Hereditary Non-Polyposis Colorectal Cancer: Translating Molecular Advances into Clinical Practice."

176. Euroconference, Human Genome Variation in Europe: DNA markers, Barcelona, Nov 9, 1995 Lecture: "DNA Mismatch Repair Gene Mutations: a "New" Class of Human Disease Susceptibility."

177. Symposium on "Genetic Aspects of Mental Retardation", University of Uppsala, Department of Clinical Genetics, December 8, 1995Lecture: "The Nordic Disease Heritage." (in Swedish)

178. Creighton University, Omaha, Nebraska, March 20, 1996Lecture: "Is Hereditary Colorectal Cancer an Example of a Cancer that is Preventable Thanks to Genetic Testing?"

179. St. Jude Children’s Research Hospital, Memphis, TN, April 11, 1996Lecture: "Is Hereditary Nonpolyposis Colorectal Cancer an Example of a Cancer that is Truly Preventable Thanks to Genetic Testing?"

180. The Baptist Memorial Health Care Foundation Forum on Cancer Research, Memphis, TN, April 12, 1996Lecture: "Is Hereditary Nonpolyposis Colorectal Cancer an Example of a Cancer that is Truly Preventable Thanks to Genetic Testing?"

181. National Cancer Institute Second International Conference "From Gene Cloning to Populations", Frederick, MD, June 27, 1996Lecture: "Population-Based Studies of Colon Cancer Susceptibility Genes."

182. University of Texas MD Anderson Cancer Center, Houston, TX, July 1, 1996 Lecture: "Population-Based Studies of Colon Cancer Susceptibility Genes in Finland."

23

Albert de la ChapelleCurriculum Vitae183. Whitehead Symposium on Cancer, Cambridge, MA, October 21, 1996

Chairman of Session and lecture: "Origins of Cancer."

184. Third Annual Genetic Linkage Symposium, San Francisco, CA, October 22, 1996 Lecture: "Replication Error and Loss of Heterozygosity in Tumors."

185. American Society of Human Genetics, Annual Meeting, San Francisco, CA, October 23, 1996Workshop Lecture: "The Finnish Population Structure as a Model of Founder Population."

186. European Society of Medical Oncology, 21st Congress, Vienna, November 4, 1996Hamilton Fairley Lecture: "Is Hereditary Non-Polyposis Colorectal Cancer an Example of a Common Cancer that is Truly Preventable Thanks to Genetic Testing?"

187. Karolinska Institute, Microbiology and Tumor Biology Center, Stockholm, January 17, 1997Lecture: "Hereditary Predisposition to Colon Cancer."

188. University of Utah, Eccles Institute of Human Genetics, Salt Lake City, UT, February 4, 1997Lecture: “Hereditary Colon Cancer.”

189. American Association of Cancer Research, Annual Meeting, San Diego, CA, April 15, 1997Organizer of Symposium and Lecture: “Identification and Management of High-Risk Individuals: Colon Cancer.”

189. UICC Symposium on Familial Cancer and Prevention, Kobe, May 14, 1997 Lecture: “HNPCC Prevention: Molecular Testing of Known Family Members and Molecular Screening in sporadic Colorectal Cancer Patients."

190. Cleveland Clinic Foundation Retreat, Salt Fork State Park, Ohio, September 8, 1997Lecture “Genes Predisposing to Colorectal Cancer.”


191. European Conference of Clinical Oncology, Annual Meeting, Hamburg, Germany, September 17, 1997 Chairman of Session and Lecture: “Prevention and Cure of Colorectal Cancer.”

192. Tenth Meeting of the International Institute of Genetics and Biophysics, CNR: Genome-Based Analysis of Gene Regulation and Its Evolution, Capri Italy, October 12, 1997Lecture: Evolution and Function of a Disease-Causing Minisatellite Expansion Mutation.”

193. American Society of Human Genetics, 47th Annual Meeting, Baltimore, MD, October 29, 1997Lecture: “The Population History of Epilepsy Mutations.”

194. Case Western Reserve University, Cleveland, Ohio, April 27, 1998Lecture: “Genetic Predisposition to Colon Cancer.”

195. University of Chicago, Chicago, Illinois, May 7, 1998 Simon M. Shubitz Cancer Lecture: “Genetic Predisposition to Colon Cancer.”

196. European Society of Human Genetics Annual Meeting, Lisbon, Portugal, May 13, 1998 Lecture: “High-and Low-Penetrance Genes in Cancer Predispositions.”

197. International Association of Cancer Registries, 32nd Annual Conference, Atlanta, Georgia, August 17, 1998Lecture: “Colon Cancer Genetics.”

198. Tim de Dombal Lecture, World Congress of Gastroenterology, Vienna, Austria, September 10, 1998 Lecture: “Molecular Screening Strategies to Identify Individuals at High Risk for Colorectal and Endometrial Cancer.”

199. XIX Congress of Polish Oncological Society, Gdansk, Poland, September 11, 1998

24


Lecture: “Genes Predisposing to Colorectal Cancer.”

200. Conference: The Future is Now: Genetics in Cancer Prevention and Diagnosis, Dayton, Ohio,September 25, 1998Lecture: “From Laboratory to Clinic: The Impact of the Discovery of Genes for Hereditary Colon Cancer on Current Patient Management.”

201. Wick R. Williams Memorial Lecture, Fox Chase Cancer Center, Philadelphia, PA, September 28, 1998Lecture: “Genetic Predisposition to Colon Cancer.”

202. Dana-Farber Cancer Institute Seminars in Oncology and the Harvard Longwood Seminar in theGenetics of Cancer and Aging, Boston, MA, December 15, 1998The David G. Nathan Lecture, “Hereditary Predisposition to Colon Cancer.”

203. Genetics and Molecular Biology…From Discovery to Practice, Honolulu, Hawaii, February 23, 1999Lecture: “Hereditary Cancer Susceptibility Syndromes.”

204. Medical Scientist Training Program, and Department of Genetics, Baylor College of Medicine, Houston, Texas, March 30, 1999Lecture: “Genetic Predisposition to Colorectal Cancer.”

205. Finnish Academy of Science, Helsinki, Finland, April 29, 1999Lecture: “Genetic Predisposition to Cancer.” (in Swedish)

206. American Society of Clinical Oncology, Thirty-Fifth Annual Meeting, Atlanta, Georgia, May 15-18, 1999 Educational Lectures: “Molecular Genetic Diagnosis for Hereditary Cancer.”

207. ECCO 10, The European Cancer Conference, Vienna, Austria, September 15, 1999Lecture: “Genes Predisposing to Colon Cancer.”

208. Department of Molecular Genetics, Biochemistry & Microbiology, University of Cincinnati, October 5,1999Lecture: “Genetic Predisposition to Colon Cancer.”

209. The Burnham Institute, San Diego, California, Distinguished Seminar Series, November 9, 1999Lecture: “Genes Predisposing to Colorectal Cancer.”


210. Department of Medical and Molecular Genetics, Indiana University School of Medicine, November 18, 1999Lecture: "Hereditary Colon Cancer."

211. Gordon Research Conference on “Genes and Cancer: Pathways, Mutations and Genomics.”, Newport, Rhode Island, August 6, 2000Keynote Lecture: “Molecular Genetics of Colon Cancer in the Clinical Context.”

212. The 12th International Collaborative Group for Hereditary Non-polyposis Colorectal Cancer Meeting, Tiberias, Israel, September 20, 2000.Lecture: ”Population-wide Molecular Screening for HNPCC-Should it be Done.”

213. The Genetic Challenge Symposium, Department of Genetics, Lund University, Lund, Sweden, October 6, 2000Keynote Lecture: “Cancer is a Genetic Disease.”

214. Rudbeck Symposium: Cancer—from Molecular Mechanisms to Clinical Therapy, Uppsala, Sweden, October 10, 2000Lecture: “Genetic Predisposition to Colon Cancer.”

25

Albert de la ChapelleCurriculum Vitae215. Gastrointestinal Cancer Symposium, University of California, San Francisco, November

14, 2000 Lecture: “Has Gene Discovery Benefitted the Colorectal Cancer Patient?”

216. Keystone Symposium: The Molecular Medicine of Colorectal Cancer, Taos, New Mexico, February 3, 2001Lecture: "Genetic Predisposition to Colorectal Cancer."

217. University of Wisconsin Genetics Colloquium on the Genetic Analysis of Human Biology, Madison, Wisconsin, February 14, 2001Lecture: "Hereditary Colon Cancer: Molecular Diagnosis, Population-wide Screening and Prevention."

218. American Association for Cancer Research, Conference on Genetic Modifiers of Cancer Susceptibility: Lessons from Human Population Studies and Mouse Models, Lake Tahoe, Nevada, February 26, 2001Lecture: "Methylation and Imprinting in Colon Cancer."

219. Université Libre de Bruxelles, Fondation Erasme, Brussels, Belgium, April 20, 2001 Lecture: “Can Genetic Testing be Used in the Prevention of Cancer?"

220. Tenth International Congress of Human Genetics, Vienna Austria, May 17, 2001 Lecture: "Has Gene Detection Benefitted the Cancer Patient?”

221. Yonsei University, Seoul, Korea, September 10, 2001Lecture: "Hereditary Nonpolyposis Colorectal Cancer: Population-based Molecular Screening and its Implications."

222. American Association for Cancer Research International Conference Seoul, Korea, September 11, 2001Lecture: "Population-based Molecular Screening for HNPCC and its Implications."

223. American Society of Human Genetics Annual Meeting, San Diego, California, October 14, 2001Lecture: "Hereditary Nonpolyposis Colorectal Cancer: Natural History, Mutation Detection and Molecular Screening."

224. National Cancer Institute, Center for Cancer Research, Bethesda, Maryland, November 13, 2001Grand Rounds Lecture: "Population-based Molecular Screening for Hereditary Nonpolyposis Colorectal Cancer and its Implications."

225. American Association for Cancer Research Conference on Colon Cancer: Genetics to Prevention, Philadelphia, PA, March 8, 2002Lecture: “Molecular Screening for Mismatch Repair Related Cancer.”

226. The Finnish Association for Medical Genetics, 25th Anniversary Seminar, Helsinki, Finland, March 22, 2002Lecture: “BAALC, the Human Member of a Novel Mammalian Neuroectoderm Gene Lineage, is Implicated in Hematopoiesis and Acute Leukemia.”


227. European Society of Human Genetics Mauro Baschirotto Award Lecture, Strasbourg, France, May 28, 2002Baschirotto Award Lecture 2002: “BAALC, the Human Member of a Novel Mammalian Neuroectoderm Gene Lineage, is Implicated in Hematopoiesis and Acute Leukemia.”

228. The Mildred Scheel Cancer Conference, Gästehaus Petersberg, Germany, September 19, 2002Keynote Lecture: “Translational Cancer Genetics: From Mismatch Repair Deficiency to Cancer Prevention.”

229. Joint International Journal of Cancer/Meyenburg-Stiftung Lectureship, Heidelberg, Germany, September 23, 2002Lecture: “Genetic and Epigenetic Predisposition to Colon Cancer.”

26

Albert de la ChapelleCurriculum Vitae230. The American Society of Human Genetics William Allan Award Presentation and Lecture,

Baltimore, MD, October 18, 2002William Allan Award Lecture: “Inherited Human Diseases: Challenges, Victories and Disappointments.”

231. Karolinska Research Lectures at Nobel Forum, The Karolinska Institute, Stockholm, Sweden, November 14, 2002Lecture: “Population-based Screening for Predisposition to Cancers Caused by Mismatch Repair Deficiency.”

232. Diagnostic Guidelines for Hereditary Non-Polyposis Colorectal Cancer and Microsatellite Instability Meeting, Bethesda, MD, December 12, 2002Lecture: “Microsatellite Instability Versus Immunohistochemistry in the Screening for Mismatch Repair Deficiency.”

233.Finnish Cancer Foundation 30th Symposium, Helsinki, Finland, February 7, 2003Lecture: “How Should the Screening and Surveillance of Hereditary Colon Cancer be Organized in Finland.”

234. Folkhälsan Institute of Genetics 40th Anniversary Seminar, Helsinki, Finland, February 14, 2003

Lecture: “Ossian Schauman’s Institute of Genetics.”

235. Folkhälsan Institute of Genetics 40th Anniversary Seminar, Helsinki, Finland, February 14, 2003Lecture: “The Genetics of Selective Intestinal Malabsorption of Vitamin B12.”

236. Danish Society of Medical Genetics 25th Anniversary Meeting, Copenhagen, Denmark, April 4, 2003Lecture: “Genetic and Epigenetic Predisposition to Colon Cancer”

237. The Environmental Mutagen Society: “Environmental Mutagenesis: From Mechanisms to Risk Assessment”, Miami, FL, May 14, 2003Lecture: “Is Large Scale Molecular Screening For Hereditary Colorectal Cancer Feasible?”

238. The Evanston Northwestern Healthcare Inaugural Henry Lynch Lectureship, Evanston, IL, May 30, 2003Lecture: “A Geneticist’s Perspective on Lynch Syndrome”

239. UICC International Conference: “Family Cancer: Biology & Clinical Care” Oklahoma City, OK, June 5, 2003Lecture: “Update on HNPCC”

240. 4th Benjamin Franklin Stem Cell Workshop, Berlin, Germany, October 22, 2004Lecture: “Challenges of ‘New’ Genes: BAALC in Acute Leukemia”

241. Fox Chase Cancer Institute: Cancer Genetics 2005, Bridging Science to Practice, Philadelphia, PA, March 8, 2005Lecture: “Genetic Predisposition to Colon Cancer”

242.American Association for Cancer Research 96th Annual Meeting, Anaheim, CA, April 18, 2005Lecture: “Genetic Predisposition to Colon Cancer”


243.Sigrid Jusélius 75th Anniversary Symposium, Helsinki, Finland, June 10, 2005Lecture: “Genetic Predisposition to Colon Cancer”

244. Wake Forest University School of Medicine: Piedmont Oncology Association Fall Symposium, Myrtle Beach, SC, September 30, 2005Lecture: “Genes in the Predisposition to Colon Cancer”

245. American Association for Cancer Research, Cancer Susceptibility and Cancer Susceptibility Syndromes, Maui, Hawaii, March 3, 2006Lecture: “The Genetic Predisposition to Colon Cancer”

27

Albert de la ChapelleCurriculum Vitae246. German Society of Human Genetics Annual Congress, Heidelberg, Germany, March 8, 2006

Lecture: “A proposal to Screen all Clorectal Cancer Patients for Predisposing Mutations”

247. American Society of Clinical Oncology Annual Meeting, Atlanta, GA, June 5, 2006Lecture: “Hereditary Colorectal Cancer: How to Integrate Testing into Clinical Practice”

248. National Cancer Institute Conference “50 Years of 46 Human Chromosomes: Progress in Cytogenetics”

Bethesda, MD, July 21, 2006Presentation: “Concluding Remarks”

249. The Colon Cancer Family Registry Conference “Etiological Pathways in Colorectal Cancer: Implications for Future Studies”, Santa Monica, CA, September 5, 2006Presentation: “Mutations in the PMS2 Gene”

250. Siteman Cancer Center, Cancer Genetics Seminar Series, Washington University, St. Louis, MO, February 13, 2007Presentation: “Colon Cancer Genes”

251. American Association for Cancer Research, Annual Meeting, Los Angeles, CA, April 17, 2007Lecture: “Genetic Testing for Colorectal Cancer Predisposition”

252. Department of Veterans Affairs. Hereditary Non-Polyposis Colorectal Cancer Advisory Meeting, Washington, DC, September 27, 2007Presentation: “Screening for Lynch Syndrome”

253. Cancer and Heredity Symposium, University of Groningen, The Netherlands, November 15, 2007Lecture: “Genes in the Predisposition to Colon Cancer”

254. Centro Nacional de Investigaciones Oncológicas Seminar Series, Madrid, Spain, January 25, 2008Lecture: “Genes in the Predisposition to Colon Cancer”

255. International Symposium on Cancer Genotypes and Cancer Phenotypes, Florence, Italy, July 5, 2008Lecture: “Genetic Predisposition to Colorectal Cancer”

256. The Cleveland Clinic Colorectal Cancer Summit, Cleveland, OH, Sept. 4, 2008Lecture: “Lynch Syndrome”

257. Collaborative Group of the Americas on Inherited Colorectal Cancer 12th Annual Meeting, Cleveland, OH, Sept. 5, 2008Jagelman Lecture: “The Role of Founder Mutations in Lynch Syndrome”

258. 79th Annual Meeting of The American Thyroid Association, Chicago, IL Oct. 3, 2008Presentation: “Genes in the Predisposition to Papillary Thyroid Cancer”

28

Albert de la ChapelleCurriculum VitaeInvited Local Talks, Lectures and SeminarsEvents Before 1971 Not Listed

1. Symposium on the Regulation of Differentiation, Helsinki, Finland, February 12, 1971Lecture: "The Use of DNA-RNA Hybridization in the Study of the Mechanisms by which Differentiation is Regulated." (in Finnish)

2. Savonlinna Medical Association, Savonlinna, Finland, February 4, 1972 Lecture: "Modern Genetic Counseling." (in Finnish)

3. Postgraduate Course, Finnish Medical Association and Scientific Associations, Helsinki, Finland, January 13, 1973Lecture: "Basic Cytogenetics and Cytogenetic Methodology." (in Finnish)

4. Department of Medicine, Kivelä Hospital, Helsinki, Finland, March 16, 1973 Lecture: "Chromosome Investigations from an Internist's Point of View." (in Finnish)

5. Grand Rounds, Aurora Hospital, Helsinki, Finland, October 24, 1973 Lecture: "Fetal Cells in the Maternal Blood." (in Finnish)

6. Finnish Society for Nuclear Technology, Helsinki, Finland, October 25, 1973 Lecture: "Biological Dose Monitoring." (in Finnish)

7. Department of Pathology, University of Oulu, Oulu, Finland, November 30, 1973 Lecture: "Human Chromosomal Inversions." (in Finnish)

8. Department of Sero-Bacteriology, University of Helsinki, Helsinki, Finland, December 14, 1973 Lecture: "Mechanisms of Mammalian Chromosome Banding I".

9. Department of Sero-Bacteriology, University of Helsinki, Helsinki, Finland, January 18, 1974 Lecture: "Mechanisms of Mammalian Chromosome Banding II."

10. Societas Genetica Fennica (Finnish Genetics Society), Annual Meeting, Turku, Finland, February 23, 1974Lecture: " The Banding of Human Chromosomes". (in Finnish)

11. Tampere Medical Association, Tampere, Finland, March 7, 1974 Lecture: "Chromosome Investigations from a Clinical Point of View." (in Finnish)

12. Postgraduate Course in Haematology, University of Helsinki, Finland, October 4, 1974 Lecture: "Significance of Chromosome Investigations in Haematology." (in Finnish)

13. Satakunta Medical Association, Pori, Finland, October 18, 1974 Lecture: "Indications for Chromosome Study." (in Finnish)

14. Kyminlaakso Medical Association, Lahti, Finland, December 3, 1974 Lecture: "Indications for Chromosme Study." (in Finnish)

15. Finska Läkaresällskapet, Helsinki, Finland, February 6, 1975Lecture: "Do Chromosome Aberrations in the Bone Marrow Lead to Leukemia?" (in Swedish)

16. Department of Pediatrics, University of Helsinki, Finland, February 12, 1971

Lecture: "Human Gene Mapping." (in Finnish)

17. Grand Rounds, Aurora Hospital, Helsinki Finland, May 7, 1975

Lecture: "Indications for Chromosome Study." (in Finnish)

18. Department of Ophthalmology, University of Helsinki, Finland, May 14, 1975 Lecture: "Basic Human Genetics for Ophthalmologists." (in Finnish)

19. Conference of Nordic Medical Laboratory Group, Helsinki, Finland, May 23, 1975 Lecture: "Indications for Chromosome Study." (in Swedish)

20. University of Turku, Finland, January 26, 1976Lecture: "The Organization of Clinical Genetics Services." (in Finnish)

29


21. Finska Vetenskaps-Societeten (The Finnish Academy of Sciences), Helsinki, Finland, February 16, 1976Lecture: "The Role of Chromosomes in Human Sex Differentiation." (in Swedish)

Invited Local Talks, Lectures and Seminars Continued

22. Grand Rounds, Central Hospital of Kotka, Finland, February 18, 1976 Lecture: "Indications for Chromosome Study." (in Finnish)

23. Course on the Diagnosis of Hereditary Metabolic Diseases Organized by the Finnish Association of Clinical Chemistry and Physiology, Helsinki, Finland, March 13, 1976Lecture: "The Study of Amniotic Fluid Samples." (in Finnish)

24. Finnish Association of Hematology, Tenth Anniversary Meeting, Helsinki, Finland, April 2, 1976 Lecture: "The Use of Bone Marrow Chromosomal Abnormalities in Human Gene Mapping."

25. Department of Radiochemistry, University of Helsinki, Finland, February 11, 1977 Lecture: "Biologic Dosimetry." (in Finnish)

26. Medical Association of Central Finland, Jyväskylä, Finland, March 23, 1977 Lecture: "Indications for Chromosome Study." (in Finnish)

27. Department of Virology, University of Helsinki, Finland, March 24, 1977 Lecture: "Mapping the Human Chromosomes."

28. Grand Rounds, Departments of Medicine, University of Helsinki, Finland, April 28, 1977 Lecture: "Chromosome Diagnostics in Hematology." (in Finnish)

29. Finnish Society of Endocrinology, 30th Anniversary Meeting, Hyvinkää, Finland, October 14, 1977 Lecture: "The Sex Chromosomes."

30. Course on Treatment of Malignant Hematologic Diseases, University of Helsinki and the Finnish Association of Hematology, Lammi, Finland, October 27, 1977Lecture: "The Significance of Chromosome Investigations of the Bone Marrow in Leukemia." (in Finnish)

31. Grand Rounds, Department of Surgery, University of Helsinki, Finland, November 25, 1977 Lecture: "Genetics in a Department of Surgery." (in Finnish)

32. Postgraduate Course, Finnish Medical Association and Scientific Associations, Helsinki, Finland, January 10, 1978Lecture: "Genetics of Chromosomal Disorders." (in Finnish)

33. Postgraduate Course, Finnish Medical Association and Scientific Associations, Helsinki, Finland, January 10, 1978Lecture: "Control of Genes, Fact or Utopia." (in Finnish)

34. Societas Biochemica, Biophysica et Microbiologica Fenniae (Finnish Society of Biochemistry, Biophysics and Microbiology) Annual Meeting, Helsinki, Finland, February 22, 1978Lecture: "The Human Gene Map." (in Finnish)

35. Mjölbollsta Hospital, Mjölbollsta, Finland, April 25, 1978Lecture: "Genetics in a Hospital for Internal Medicine." (in Swedish)

34. Dental Research Day, University of Turku, Finland, September 29, 1978 Lecture: "Medical Genetics and Some of its Details." (in Finnish)

35. Radiation Protection Days, Helsinki, Finland, October 17, 1978 Lecture: "Genetic Effects of Ionizing Radiation." (in Finnish)

38. Course in Clinical Genetics, University of Helsinki, and Finnish Association of Medical Genetics, Lammi, Finland, October 12, 1978Lecture: "The Molecular Basis of Inheritance and the Human Gene Map." (in Finnish)

39. Course in Clinical Genetics, University of Helsinki, and Finnish Association of Medical Genetics, Lammi, Finland, October 12, 1978

30


Lecture: "Abnormalities of the Sex Chromosomes." (in Finnish)

40. Molecular Biology Days, Helsinki, Finland, October 26, 1978Lecture: "Are Testes Induced by Multiple Genes after All? Genealogy and H-Y Antigen." (in Finnish)


41. Nordic Ecumenic Union, Seminar, Tuusula, Finland, November 17, 1978 Lecture: "Genetic Research To-Day and in the Future." (in Swedish)

42. Fourth Department of Medicine, University of Helsinki, Finland, December 12, 1978 Lecture: "Genetics at a Department of Medicine." (in Swedish)

43 Symposium on Acute Leukemia, Postgraduate Course, Finnish Medical Association and Scientific Associations, Helsinki, Finland, January 12, 1979

Lecture: "Chromosomal Aberrations in Acute Leukemia."

44.Department of Obstetrics and Gynecology, University of Helsinki, Finland, March 16, 1979 Lecture: "The Role of Chromosome Abnormalities in Infertility." (in Finnish)

45.Nordic Symposium organized by the Finnish Association of Pathology, Helsinki, Finland, March 21, 1979

Lecture: "Hereditary Disorders that are Common in Finland." (in Swedish)

46. Critical University, Helsinki, Finland, April 2, 1979Lecture: "Genetic Research and the Responsibility for Man." (in Finnish)

47. Course on Alternative Approaches to Medicine, Helsinki, Finland, September 28, 1979 Lecture: "What Does Genetics Have to Offer the Physician." (in Finnish)

48. Businessmen's Association, Helsinki, Finland, November 22, 1979 Lecture: "Genetics in the Service of the Community." (in Swedish)

49. Midwifery Hospital, Helsinki, Finland, March 12, 1980Lecture: "Prenatal Diagnosis in Finland." (in Finnish)

48. Finnish Association of Sports Medicine, Helsinki, Finland, April 11, 1980 Lecture: "The Use and Misuse of Cytologic Methods for the Determination of Sex." (in Finnish)

49. Department of Radiotherapy, University of Helsinki, Finland, September 4, 1980 Lecture: "Chromosome Investigations in Lymphoma." (in Finnish)

52. Finnish Leukemia Group, Turku, Finland, September 26, 1980Lecture: "Chromosome Investigations in Myeloma." (in Finnish)

53. Symposium on Endocrinology of Puberty. Postgraduate Courses, Finnish Medical Association and Scientific Associations, Helsinki, Finland, January 9, 1981Lecture: "Genetic Determination of Maleness."

54. Symposium on Chemotherapy, Finnish Cancer Foundation, Tuusula, Finland, February 14, 1981 Lecture: "Genetic Late Effects of Cytostatic Drugs."

55. Department of Radiotherapy, University of Helsinki, Finland, February 27, 1981 Lecture: "Chromosome Investigations of Tumors."

56. Course on Lymphoma, Finnish Association of Hematology, Lammi, Finland, October 21, 1982Lecture: "Specific Translocations and Their Significance in the Etiology and Diagnosis of Burkitt's Lymphoma." (in Finnish)

64. Seminars in Clinical Genetics, University of Helsinki, Finland, November 12, 1982 Lecture: "The Etiology of XX Males." (in Finnish)

58. Finska Vetenskaps-Societeten (Finnish Academy of Sciences), Helsinki, Finland, January 17, 1983Lecture (as a recipient of the E.J. Nyström Prize): "Modern Genetics at the Service of Medicine." (in Swedish)

31


59. Department of Medicine, University of Turku, Finland, April 13, 1983 Lecture: "What's New in the Chromosomes of Leukemias and Tumors." (in Finnish)

60. Department of Pediatrics, University of Turku, Finland, April 13, 1983 Lecture: "Present-Day Indications for Chromosome Study." (in Finnish)

61.Department of Biochemistry, University of Helsinki, Helsinki, Finland, April 29, 1983 Lecture: "In situ DNA Hybridization."


62. Department of Virology, University of Helsinki, Helsinki, Finland, May 5, 1983 Lecture: "Localization of Genes by in situ Hybridization." (in Finnish)

63. Finnish Association of Medical Genetics, Oulu, Finland, May 13, 1983 Lecture: "DNA Technology in the Diagnosis of Hereditary Disease." (in Finnish)

64. Symposium on Genetics in Cancer, Finnish Association of Medical Genetics, Helsinki, Finland, September 30, 1983Lecture: "Chromosomal Breakpoints Associated with Neoplasia."

65. Social Sciences Circle, Helsinki, Finland, March 5, 1984Lecture: "Are We Ready for the Modern Genetics?" (in Swedish)

66. Finska Läkaresällskapet (Finnish Medical Society), Helsinki, Finland, November 24, 1983 Lecture: "Clinical Genetics in the Service of Health Care: Tasks and Organization." (in Swedish)

67. Symposium on Tumor Markers in the Clinical Diagnosis and Monitoring of Cancer. Postgraduate Courses, Finnish Medical Association and Scientific Associations, Helsinki, Finland, January 10, 1984Lecture: "Chromosomal Breakpoints in Malignancy."

68. Course on the Medical Applications of Gene Technology, University of Helsinki, Finland, April 4, 1984 Lecture: "Diagnosis of Hereditary Disorders by Nucleic Acid Hybridization Techniques." (in Finnish)

69. The Minerva Foundation, 25th Anniversary, Helsinki, Finland, April 6, 1984 Lecture: "Could our Research Policies Be Improved?" (in Swedish)

70. Course in Clinical Genetics arranged by the Finnish Association of Medical Genetics and the University of Helsinki, Lammi, Finland, November 8-10, 1984Lecture: "Recombinant DNA Technology in the Diagnosis of Hereditary Disorders." (in Finnish)

71. Course in Clinical Genetics arranged by the Finnish Association of Medical Genetics and the University of Helsinki, Lammi, November 8-10, 1984Lecture: "Clinical Consequences of Sex Chromosome Abnormalities." (in Finnish)

72. Department of Biology, Åbo Akademi, Åbo, Finland, December 3, 1984Lecture: "Chromosome Translocations and Oncogenes in the Etiology of Leukemia and Cancer." (in Swedish)

73. Course in Gene Technology, Helsinki, Finland, January 22, 1985 Lecture: "Gene Therapy." (in Finnish)

74. Grand Rounds, Departments of Medicine, Meilahti Hospital, University of Helsinki, February 28, 1985 Lecture: "The Genetics and Cytogenetics of Malignant Neoplasms." (in Finnish)

75. Finnish Association of Medical Genetics, Helsinki, Finland, March 22, 1985Lecture: "Recombinant DNA Techniques in the Diagnosis of Duchenne Muscular Dystrophy." (in Finnish)

76. Department of Gene Technology, University of Helsinki, May 6, 1985 Lecture: "Diagnosis of X-chromosomal Muscular Dystrophies." (in Finnish)

77. The Finska Läkaresällskapet (Finnish Medical Society), Helsinki 150th Anniversary Celebration, October 11, 1985"Presidential Address." (in Swedish)

32


78. The Finska Läkaresällskapet (Finnish Medical Society), Helsinki, Annual Meeting, January 25, 1986 Lecture: "In Search of the Masculinizing Gene." (in Swedish)

79. The Medicinarklubben Thorax (Association of Medical Students), Helsinki, Annual Meeting, March 8, 1986Lecture: "Why Sex Chromatin should be Abandoned as a Screening Method for Female Athletes." (in Swedish)

80. IV Paulo Symposium on "Recombinant DNA in Clinical Medicine", Helsinki, Finland, August 25, 1986 Lecture: "Human X-linked Disorders."


81. Department of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland, September 12, 1986Lecture: "DNA Technology in the Diagnosis of Hereditary Disorders." (in Finnish)

82. Departments of Medical and Clinical Genetics, University of Helsinki, Finland, September 12, 1986 Lecture: "DNA Diagnosis in Finland To-day."

83. Division of Child Neurology, University of Helsinki, Finland, November 19, 1986 Lecture: "Molecular Diagnosis of Muscular Dystrophies." (in Finnish)

84. Department of Clinical Chemistry, University of Kuopio, Finland, November 18, 1987 Lecture: "Cytogenetic and Molecular Diagnosis of Cancer." (in Finnish)

85. The Finnish Cancer Societies, Symposium on Leukemia and Lymphoma, Tuusula, Finland, February 11, 1988Lecture: "Cytogenetics and Molecular Genetics of Leukemias and Lymphomas." (in Finnish)

86. The Finnish Society of Gynecology and Obstetrics, and the Finnish Society of Medical Genetics, Joint Meeting, Helsinki, Finland, May 6, 1988Lecture: "DNA Studies in Prenatal Diagnosis." (in Finnish)

87. Biocenter, University of Oulu, Finland, May 12, 1988Lecture: "The Molecular Genetics of Sex Determination." (in Finnish)

88. Department of Pathology, University of Helsinki, Finland, September 14, 1988 Lecture: "Primary Sex Determination in Man."

89. Department of Gene Technology, University of Helsinki, Finland, November 14, 1988 Lecture: "The Molecular Genetics of Sex Determination."

90. Department of Neurology, University of Helsinki, Finland, November 22, 1988Lecture: "The Molecular Basis of Duchenne Muscular Dystrophy." (in Finnish)

91. Seminar on Sports Medicine, Lahti, Finland, February 15, 1989 Lecture: "Gender Verification."

92. Finnish-French cultural seminar, University of Helsinki, Finland, October 14, 1989 Lecture: Contacts between Finland and France in Medicine. (in Finnish)

93. Department of Physiology, University of Turku, Finland, October 31, 1989 Lecture: "The Molecular Genetics of Sex Determination."

94. Samfundet Folkhälsan, Conference on Genetics - Fact or Fiction, Helsinki, Finland, November 1, 1989 Lecture: "Genetics at the Service of Medicine." (in Swedish)

95. Grand Rounds, Meilahti Hospital, Helsinki University Central Hospital, Helsinki, Finland, November 2, 1989.Lecture: "Sex Determination." (in Finnish)

96. Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki Finland, November 3, 1989.Lecture: "What is New in the Genetics of Sex Determination." (in Finnish)

33


97. Opening of the Annual Medical Assembly, Finnish Medical Societies, Helsinki, Finland, January 7, 1990Matti Äyräpää lecture: "The New Genetics in Medicine." (in Finnish)

98. Finnish Cancer Societies, Symposium on Cancer of the Colon and Rectum, Tuusula, Finland, February 8, 1990Lecture: "The Genetics of Colon Cancer." (in Finnish)

99. Department of Pediatrics, University of Helsinki, Finland, April 18, 1990 Lecture of the Month: "New Diagnostic Procedures in Clinical Genetics." (in Finnish)

100. Finska Läkaresällskapet, Helsinki, Finland, April 19, 1990Lecture: "Gene Diagnosis." (in Swedish)


101. International Symposium on Clinical Medicine and Molecular Genetics, Helsinki, Finland, April 20, 1990 Lecture: "DNA Diagnostics of Cancer."

102. Duodecim Society of Oulu, Postgraduate Course, Oulu, Finland, November 22, 1990 Lecture: "The Achievements of Gene Research."

103. Duodecim Society of Mikkeli, Finland, January 26, 1991Lecture: "The New Genetics in Medicine." (in Finnish)

104. Neurology Association of Finland, 30th Anniversary Meeting, Helsinki, Finland, February 15, 1991 Lecture: "The Molecular Genetics of X Chromosomal Hereditary Muscle Disorders."(in Finnish

105. Grand Rounds, Helsinki University Central Hospital, Helsinki, Finland, November 14, 1991 Lecture: "Human Gene Mapping - the Situation Today." (in Finnish)

106. Endocrinology Rounds, Department of Pediatrics, University of Helsinki, Finland, February 19, 1992 Lecture: "Molecular Genetics of the Y Chromosme." (in Finnish)

107. Duodecim Society of Kuopio, 70th Anniversary Symposium, Kuopio, Finland, February 22, 1992 Lecture: "Genes and Diseases." (in Finnish)

108. Helsinki University of Technology, Espoo, Finland, September 18, 1992 Lecture: "Mapping the Human Genome." (in Finnish)

109. Odontologiska Samfundet, Annual Meeting, Helsinki, Finland, January 29, 1993 Lecture: "The Big Genome Project." (in Swedish)

110. Institute of Biotechnology, University of Helsinki, February 7, 1994 Lecture: "The Cancer Susceptibility Gene on Human Chromosome 2".

111. Grand Rounds, Helsinki University Central Hospital, Helsinki, Finland, September 8, 1994 Lecture: "Gene Defects in Colon Cancer" (in Finnish)

112. Grand Rounds, Aurora Hospital, Helsinki, December 2, 1994 Lecture: "The Finnish Disease Heritage" (in Finnish)

113. The Minerva Foundation - Medix Company Seminar, Helsinki, December 15, 1994 Lecture: "Genetic Testing" (in Swedish)

114. Finska Vetenskapssocieteten (Finland's Senior Academy of Sciences and Letters), Helsinki, December 19, 1994Lecture: "Hereditary Cancer" (in Swedish)

115. Grand Rounds, Fourth Department of Medicine, Helsinki, December 21, 1994 Lecture: "Hereditary Colon Cancer" (in Swedish)

116. Medicine 95, Workshop on Hereditary Cancer, Helsinki, January 9, 1995 Lecture: "Gene Defect Causing Hereditary Nonpolypotic Colon Cancer"

117. The Medical Society Duodecim, Postgraduate School on Genes in Clinical Medicine, Tusby, September 1, 1995Lecture: "Hereditary Colon Cancer" (in Finnish)

34


118. Esko Nikkilä Lecture, 65th Annual Meeting of the Finnish Society of Physicians in Internal Medicine, Helsinki, February 2, 1996Lecture: "Is Hereditary Colon Cancer an Example of a Cancer that is Truly Preventable Thanks to Genetic Testing?"

119. The Haartman Seminars, University of Helsinki, May 8, 1996Lecture: "The Finnish Disease Heritage"

120. Institute of Biomedicine, University of Helsinki, May 22, 1996Lecture: "What’s New in Human Gene Mapping and Cloning"


121. University of Helsinki, General Public Lecture Series, October 8, 1996Lecture: Are the Advances in Genetic Research Directly Promoting the Fight Against Diseases?" (in Swedish)

122. Graduate Schools in Medicine, Helsinki, February 16, 1997Lecture: “The Graduate School in Medical Genetics” (in Finnish)

123. Finnish Association of Medical Genetics, Annual Meeting, Oulu March 21, 1997 Lecture: “What’s Up in Genetics” (in Finnish)

124. Ohio State University Comprehensive Cancer Center, Medical Grand Rounds, Columbus, Ohio, September 26 ,1997.Lecture: “Genetic Predisposition to Colon Cancer”

125. Second Tvärminne Symposium on the Origins of the Finns Lammi, Finland October 11, 1997 Lecture: “What Does Gene Research Tell Us About the Finns? A Comment”

126. The Ohio State University Medical Center, 4th Annual Oncology Update: Colorectal Cancer, December 6, 1997Lecture: “Is Hereditary Colorectal Cancer Preventable Thanks to Genetic Testing?”

127. The Medical Scientist Student Organization of the Ohio State University Forum, December 12, 1997 Lecture: “Is Predictive Testing for Common Cancers Now a Reality?”

128. Chromosome and Gene Alterations in Cancer and Their Clinical Significance, Haartman Institute, Helsinki, Finland, November 30, 1998Lecture: “Cancer Genetics”

129. Grand Rounds, Riverside Methodist Hospital, Columbus, Ohio, May 25, 1999Lecture: “Familial Non-Polyposis Colon Cancer”

130. The Ohio State Winter College, Naples, Florida, January 27, 2001 Lecture: "The Contribution of Genetics to the Detection, Prevention, and Treatment of Cancer"

131. The Samfundet Folkhälsan 80th Anniversary Celebration, University of Helsinki, March 16, 2001 Lecture: "Medical Research: Successes and Disappointments" (in Swedish)

132. Ohio State University Comprehensive Cancer Center, Fourth Annual Scientific Meeting "Genomics and Cancer Biology" Dublin, Ohio, January 11, 2002Lecture: "Genetic and Epigenetic Susceptibility to Colon Cancer: The Columbus Study"

133. The Ohio State University James Cancer Hospital and Solove Research Institute " The James Update: GI Oncology" Conference, Columbus, Ohio, April 26, 2003Lecture: "The Genetics of GI Cancer"

134. The Ohio Department of Health/The Ohio Cancer Incidence Surveillance System and the American Cancer Society, Ohio Division, Inc. "The Ohio Cancer Symposium 2003: Data into Action-The Ohio Cancer Plan", Columbus, Ohio May 3, 2003Lecture: "Screening and Surveillance of Hereditary Cancer: The Columbus Study"

135. The Ohio State University Clinical Cancer Genetics Program, “Cancer Genetics Short Course”, Columbus, Ohio, April 22, 2004Lecture: “Hereditary Nonpolyposis Colorectal Cancer”

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136. The Ohio State University James Cancer Hospital and Solove Research Institute, Ernest L. Mazzaferri Thyroid Cancer Conference, “Thyroid Cancer from Predisposition to Therapy: A Bench to Bedside Symposium”, November 5, 2004, Columbus, OhioLecture: “Heritability of Thyroid Cancer”

137. The Ohio State University James Cancer Hospital and Solove Research Institute, Ernest L. Mazzaferri Thyroid Cancer Conference, “Thyroid Cancer from Predisposition to Therapy: A Bench to Bedside Symposium”, November 5, 2004, Columbus, OhioLecture: “Genetic Predisposition to Papillary Thyroid Cancer”


138. The Ohio State University James Cancer Hospital and Solove Research Institute, Gastrointestinal Conference, “Gastrointestinal Cancer 2005: Current Updates on State of the Art Management”, August 26, 2005, Columbus, OhioKeynote Address: “Genetics of Colorectal Cancer”

139. The Ohio State University Comprehensive Cancer Center, Cancer Genetics Conference, “An Update on Colorectal Cancer Genetics”, March 2, 2007, Columbus, OhioLecture: “Colon Cancer Genes”

140. The Ohio State University, Department of Molecular Virology, Immunology and Medical Genetics, Faculty seminar, March 10, 2008, Columbus, OhioLecture: “Genes in the predisposition to papillary thyroid cancer. A progress report”

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Albert de la ChapelleCurriculum VitaeSubmitted Papers and Posters Presented at Scientific Meetings

1. Nordman CT, Weber T, de la Chapelle A, Gräsbeck R: The Leucocyte-mitogenic action of leucoagglutins. Tenth Congress of the International Society of Hematology, Stockholm, Sweden, 1964

2. Leisti J, Aula P, de la Chapelle A: Klinefelter's syndrome with XXYY sex chromosomes. Third Conference of the Nordic Society of Geneticists, Helsinki, Finland, 1964

3. Hortling H, de la Chapelle A, Johansson C-J, Niemi M, Sulamaa M: Endocrinological observations in operated cases of cryptorchism. Acta Endocrinologica Congress, Hamburg, Germany, 1965

4. de la Chapelle A, Hortling H, Wennström J, Niemi M, Johansson C-J: Two males with female chromosomes. Acta Endocrinologica Congress, Hamburg, Germany, 1965

5. de la Chapelle A: Isochromosome-X in man. Fourth Conference of the Nordic Society of Geneticists, Lund, Sweden, 1966

6. de la Chapelle A, Wennström J: Cytogenetic and autoradiographic investigations in the XX male syndrome. Third International Congress of Human Genetics, Chicago, Illinois, USA, 1966

7. Fantoni A, de la Chapelle A, Marks PA: RNA and protein synthesis in developing erythroid cells of yolk sac and liver. Federation Meetings, Chicago, Illinois, USA 1967

8. de la Chapelle A, Fantoni A, Rifkind RA, Marks PA: Erythroid cell development; decay rates of synthetic capacity for different proteins. Meeting of The American Society for Clinical Investigation, Atlantic City, New Jersey, USA, 1967

9. Fantoni A, de la Chapelle A, Rifkind RA, Marks PA: Differentiation of erythroid cells in fetal mice. Meeting of The American Society of Hematology, Toronto, Ontario, Canada, 1967

10. de la Chapelle A, Fantoni A, Marks PA: Differentiation of erythroid cells: decay rates of synthetic capacity for three embryonic hemoglobins. Federation Meetings, Atlantic City, New Jersey, USA, 1968

11. Fantoni A, de la Chapelle A, Chui D, Rifkind RA, Marks PA: Control mechanisms of the conversion from synthesis of embryonic to adult hemoglobin. Second Conference on the Problems of Cooley's Anemia, New York Academy of Sciences, New York, USA, 1968

12. Fantoni A, de la Chapelle A, Marks PA: Cell replication and stabilization of hemoglobin synthesis in differentiating erythroid cells. Twelfth Congress of the International Society of Hematology, New York, New York, USA, 1968

13. Djaldetti M, Fantoni A, de la Chapelle A, Marks PA, Rifkind RA: Studies on the cellular basis of stabilization of hemoglobin synthetic capacities as erythroid cells differentiate. Meeting of The American Society of Cell Biology, Boston, MA, USA, 1968

14. de la Chapelle A, Selander R-K: Mechanisms controlling the differentiation of erythroid cells in fetal mice. Joint Meeting of the Nordic Society of Geneticists and the Nordic Society of Cell Biologists, Reykjavik, Iceland, 1969

15. de la Chapelle A, Fantoni A, Marks PA: Differentiation of mammalian somatic cells: The patterns of ribosome content, polysome distribution and RNA synthesis in differentiating mouse erythroid cells. FEBS Sixth Meeting, Madrid, Spain, 1969

16. de la Chapelle A: The cytogenetics of male hypogonadism. Meeting of the Nordic Fertility Club, Helsinki, Finland, 1970

17. de la Chapelle A, Schröder J: Possible assessment of foetal sex in man from cells in the maternal circulation. Scandinavian Microsymposium on Cell Genetics, Helsinki, Finland, 1970

18. de la Chapelle A, Selander R-K: Transcription in differentiating foetal erythroid cells. Medical Research Meeting, Scientific Societies of Finland, Helsinki, 1970

19. Selander R-K, de la Chapelle A: Erythroid cell specialization. DNA-RNA hybridization experiments. Medical Research Meeting, Scientific Societies of Finland, Helsinki, 1971

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20. Kirjarinta M, Eriksson AW, Lehtosalo T, Knutar F, de la Chapelle A: C trisomy and red cell glutathione reductase activity. Medical Research Meeting, Scientific Societies of Finland, Helsinki, 1971

Submitted Papers at Meetings Continued

21. de la Chapelle A, Eriksson AW, Kirjarinta M, Knutar F: Glutathione reductase activity in haematological disorders associated with C trisomy. Meeting of the European Society of Clinical Investigation, Scheveningen, The Netherlands, 1971

22. de la Chapelle A, Schröder J: Cytogenetics of C trisomy in haematological disease. Fourth International Congress of Human Genetics, Paris, France, 1971

23. Schröder J, de la Chapelle A: Foetal lymphocytes in the maternal circulation. Fourth International Congress of Human Genetics, Paris, France, 1971

24. de la Chapelle A, Selander R-K, Schröder J: The localization and properties of different types of DNA in eukaryote chromosomes. Medical Research Meetings, Scientific Societies of Finland, Helsinki, Finland, 1972

25. Schröder J, Selander R-K, de la Chapelle A: Selective in situ denaturation of human chromosome regions containing satellite DNA. Medical Research Meetings, Scientific Societies of Finland, Helsinki, Finland, 1972

26. de la Chapelle A, Schröder J, Selander R-K: Cytological demonstration of repetitious DNA in mammalian chromosomes using acridine dyes. Fourth International Chromosome Conference, Jerusalem, Israel, 1972

27. de la Chapelle A, Schröder J: Apparently non-reciprocal balanced human (3q-;Xq+) translocation: Late replication of structurally normal X. Fourth International Chromosome Conference, Jerusalem, Israel, 1972

28. de la Chapelle A, Schröder J, Räihä N, Tiilikainen A: Antenatal diagnosis of sex and the immunological interactions between mother and foetus. A study of foetal lymphocytes in the maternal circulation. Symposium on Somatic Cell Genetics, European Society of Human Genetics, Amsterdam, The Netherlands, 1972

29. Schröder J, Selander R-K, de la Chapelle A: Acridine orange reveals regions containing satellite DNA in mammalian chromosomes. Symposium on Somatic Cell Genetics, European Society of Human Genetics, Amsterdam, The Netherlands, 1972

30. Schröder J, Tiilikainen A, de la Chapelle A: Immunological aspects of foetal cells in the maternal blood 1. Kinetics. Meeting of the Scandinavian Society of Immunology, Oslo, Norway, 1973

31. Tiilikainen A, Schröder J, de la Chapelle A: Immunological aspects of foetal cells in the maternal blood 2. Masking of paternal HL-A antigens. Meeting of the Scandinavian Society of Immunology, Oslo, Norway, 1973

32. de la Chapelle A, Tiilikainen A, Schröder J: Significance of foetal cells in the maternal blood. Meeting of the European Society for Clinical Investigation, Rotterdam, The Netherlands, 1973

33. de la Chapelle A, Schröder J, Ikkala E, Vuopio P: Significance of 8-trisomy in the bone marrow. Symposium of the European Society of Human Genetics, Pavia, Italy, 1973

34. Schröder J, Tiilikainen A, de la Chapelle A: Occurrence of fetal cells in the maternal blood. Fourth International Conference on Birth Defects. Vienna, Austria, 1973

35. Vuopio P, Niskanen E, de la Chapelle A: Preleukemia. Fifth Meeting of the Nordic Society of Hematology, Stockholm, Sweden, 1974

36. de la Chapelle A: Glutathione reductase and chromosome 8. (Discussion) Second Conference on Human Gene Mapping, Rotterdam, The Netherlands, 1974

37. de la Chapelle A: Pericentric inversions in human C group chromosomes. (Discussion) Second Conference on Human Gene Mapping, Rotterdam, The Netherlands, 1974

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38. de la Chapelle A, Schröder J, Herva R: Minor pericentric inversions of human chromosomes 9 and 10. Fourth Workshop of the Section of Cytogenetics of the German Society of Anthropology and Human Genetics, Berlin, Germany, 1974

39. de la Chapelle A, Selander R-K, Simola K: Interaction of quinacrine mustard with repetitious DNA in solution. Fifth International Chromosome Conference, Leiden, The Netherlands, 1974


40. de la Chapelle A: Transfer of leukocytes from foetus to mother. Symposium of the European Society of Human Genetics, Freiburg, Germany, 1975

41. de la Chapelle A: Alternative methods (Discussion). European Conference on the Parental Diagnosis of Genetic Disorders of the Foetus. Stockholm, Sweden, 1975

42. de la Chapelle A: Rationale for the use of cytogenetic abnormalities of bone marrow cells in mapping by gene dosage (Discussion). Third International Workshop on Human Gene Mapping, Baltimore, Maryland, USA, 1975

43. de la Chapelle A, Vuopio P, Icén A: Red cell glutathione reductase activity in patients with bone marrow trisomy 8. Third International Workshop on Human Gene Mapping, Baltimore, Maryland, USA, 1975

44. de la Chapelle A, Vuopio P, Sanger R, Teesdale P: The Colton blood groups in monosomy 7 of the bone marrow. Third International Workshop on Human Gene Mapping, Baltimore, Maryland, USA, 1975

45. Limon J, Selander R-K, de la Chapelle A: Cytogenetic and physicochemical investigations with fluorescent acridine derivatives (in Polish). Sixth Meeting of the Polish Society of Genetics, Bialystok, Poland, 1976

46. Turunen O, Lundqvist C, de la Chapelle A: Fetal cells in the maternal blood. Differential effect of mitogens on maternal and fetal lymphocytes. Fifth International Congress of Human Genetics, Mexico City, Mexico, 1976

47. Lundqvist C, Schröder J, de la Chapelle A, Himberg M: The karyotype of Coregonus nasus sensu Svärdson from the Archipelago of Åland. Eighth Meeting of the Nordic Society of Geneticists, Turku, Finland, 1976

48. de la Chapelle A: The genetics of human XX males. Symposium of the European Society of Human Genetics, Oslo, Norway, 1977

49. Turunen O, Lundqvist C, de la Chapelle A: In vitro effect of lipopolysaccharide B on human fetal lymphocytes. Symposium of the European Society of Human Genetics, Oslo, Norway, 1977

50. Simon J, Selander R-K, de la Chapelle A, Ledochowski A: Fluorescence of 9-aminoacridine derivatives with nucleic acid polymers. Sixth International Chromosome Conference, Helsinki, Finland, 1977

51. Lundqvist C, Turunen O, de la Chapelle A: Mitogenic response of human adult and cord blood lymphocytes to polyclonal B-cell activators. Meeting of the Scandinavian Society of Immunology, Stockholm, Sweden, 1977

52. de la Chapelle A, Simola K, Karli P, Lindenbaum RH, Robson EB, Cook PJL, Buckton KE: Linkage data on chromosome 11. Fifth International Workshop on Human Gene Mapping, Winnipeg, Manitoba, 1977

53. Turunen O, Lundqvist C, Julin M, Holmlund G, Tiilikainen A, de la Chapelle A: The mitogenic activity of rabbit antisera made against human fetal cells. Meeting of the Scandinavian Society of Immunology, Oslo, Norway, 1978

54. de la Chapelle A: Genes on chromosome 7. Symposium of the European Society of Human Genetics, Vienna, Austria, 1978

55. Borgström GH, Teerenhovi L, Vuopio P, de la Chapelle A, Brandt L, Golomb H, Mitelman F, Rowley J, Sandberg AA, Syuiti A: 7 monosomy in acute non-lymphocytic leukemia. A

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cytogenetical and clinical study. Satellite Symposium of the Seventeenth International Conference of Hematology, Poitiers, France, 1978

56. Vuopio P, Ruutu P, Repo H, Hänninen A, de la Chapelle A: Defective neutrophil chemotaxis in refractory idiopathic sideroblastic anemia. Seventeenth International Conference of Hematology, Paris, France, 1978

57. Alvesalo L, de la Chapelle A: Permanent tooth sizes in 46,XX males. Sixteenth International Congress of Genetics, Moscow, Soviet Union, 1978


58. Schröder J, Turunen O, Lundqvist C, de la Chapelle A: Maternal blood as a source of foetal cells for prenatal diagnosis. Third European Conference on Prenatal Diagnosis of Genetic Disorders. Munich, Germany, 1978

59. Simola K, de la Chapelle A, Aula P, Karli P: Prenatal diagnosis by means of genetic linkage. Third European Conference on Prenatal Diagnosis of Genetic Disorders. Munich, Germany, 1978

60. Autio K, Turunen O, de la Chapelle A, Schröder J: Chromosome studies in different lymphocyte populations in CLL. Fifth Meeting of the European and African Division of the International Society of Haematology, Hamburg, Germany, 1979

61. Schröder J, Autio K, de la Chapelle A: Karyotypes in CLL: Evidence from mouse and man. Fifth Meeting of the European and African Division of the International Society of Haematology, Hamburg, Germany, 1979

62. Borgström GH, Teerenhovi L, Ruutu T, Jansson S-E, Vuopio P, de la Chapelle A: Preleukemic refractory anemia with 5q- karyotype. Fifth Meeting of the European and African Division of the International Society of Haematology, Hamburg, Germany, 1979

63. Teerenhovi L, Borgström GH, Lintula R-L, de la Chapelle A, Vuopio P: Karyotypes in preleukemic refractory idiopathic sideroblastic anemia. Fifth Meeting of the European and African Division of the International Society of Haematology, Hamburg, Germany, 1979

64. de la Chapelle A, Alvesalo L: Mapping of the growth promoting gene(s) on the human Y chromosome. Sixth International Human Gene Mapping Workshop, Edinburgh, Scotland, 1979

65. de la Chapelle A, Gahmberg CG, Andersson LC, Ruutu T, Ruutu P, Kosunen TU, Repo H, Vuopio P: A granulocyte membrane glycoprotein possibly involved in locomotion and coded for by chromosome 7. Sixth International Human Gene Mapping Workshop, Edinburgh, Scotland, 1979

66. Ruutu P, Ruutu T, Repo H, Vuopio P, Timonen T, Kosunen TU, de la Chapelle A: Defective neutrophil migration in monosomy-7. Eighteenth Congress of the International Society of Hematology, Montreal, Quebec, Canada, 1980

67. Teerenhovi L, Borgström GH, Lintula R-L, Vuopio P, de la Chapelle A: Karyotypic evolution in patients with preleukemia developing acute leukemia. Eighteenth Congress of the International Society of Hematology, Montreal, Quebec, Canada, 1980

68. Borgström GH, Teerenhovi L, Vuopio P, Andersson L, Knuutila S, Elonen E, de la Chapelle A: Chromosome studies in adult acute lymphoblastic leukemia. Eighteenth Congress of the International Society of Hematology, Montreal, Quebec, Canada, 1980

69. Knuutila S, Vuopio P, Borgström GH, de la Chapelle A: Higher frequency of a 5q- clone in bone marrow cells with methotrexate than with the direct method. Eighteenth Congress of the International Society of Hematology, Montreal, Quebec, Canada, 1980

70. Borgström GH, Knuutila S, Vuopio P, Elonen E, Siimes M, de la Chapelle A: Advantage of short-term bone marrow culture in chromosome studies of haematological disorders.

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Sixth Meeting of the European and African Division of the International Society of Haematology, Athens, Greece, 1981

71. Herva R, de la Chapelle A: DiGeorge syndrome: Evidence for specific deletion of 22q11. Sixth International Congress of Human Genetics, Jerusalem, Israel, 1981

72. Knuutila S, Vuopio P, Borgström GH, de la Chapelle A: Clonal chromosome aberrations in bone marrow and blood from patients with haematological disorders: A comparison of the two cell types. Sixth International Congress of Human Genetics, Jerusalem, Israel, 1981

73. de la Chapelle A, Herva R: Monosomy for gene(s) in 22q11 can cause DiGeorge's syndrome. Sixth International Human Gene Mapping Workshop, Oslo, Norway, 1981

74.de la Chapelle A, Ruutu P, Ruutu T, Repo H, Vuopio P, Timonen T, Kosunen TU: The locomotion defect of granulocytes in monosomy 7 involves random locomotion, chemotaxis, and chemokinesis. Sixth International Human Gene Mapping Workshop, Oslo, Norway, 1981


75.Simola K, de la Chapelle A, Pirkola A, Karli P, Cook PJL, Tippett PA: Data on DM:Le linkage. Sixth International Human Gene Mapping Workshop, Oslo, Norway, 1981

76.Salonen R, de la Chapelle A: Partial 4q monosomy/10q trisomy phenotype in a large family. International Postgraduate Course on Identification of Genetic Syndromes in Pediatrics. Florence, Italy, 1982

77. de la Chapelle A, Lenoir G, Boué A, Gallano P, Huerre C, Jeanpierre M, Kaplan J-C: Lambda Ig constant region localized in band 22q11 and translocated to chromosome 8 in Burkitt's lymphoma with t(8;22). Seventh International Human Gene Mapping Workshop, Los Angeles, California, USA, 1983

78. Jensen PKA, Junien C, de la Chapelle A: Gene for glutathione reductase localized to subband 8p21.1. Seventh International Human Gene Mapping Workshop, Los Angeles, California, USA, 1983

79. Simola KOJ, Knuutila S, Kaitila I, de la Chapelle A: A separate gene for aniridia at 11p13. Seventh International Human Gene Mapping Workshop, Los Angeles, California, USA, 1983

80. Welin M-G, Miettinen E-L, Luotola J, de la Chapelle A, Weber TH: Detection of B-lymphocytes in peripheral blood and other tissues by immunohistochemical methods using monoclonal, Ia-like antigen specific, antibodies. Colloqium on Protides of the Biological Fluids, Brugge, Belgium, 1983

81. Page DC, de la Chapelle A, Vergnaud G, Botstein D, Weissenbach J: Y-specific DNA in human XX males. Meeting of the American Society of Human Genetics, Toronto, Canada, 1984

82. de la Chapelle A, Knuutila S, Elonen E: Recurrent translocation (2;11)(p21;q23) in myelodysplastic syndrome and acute non-lymphocytic leukemia. Eighth International Human Gene Mapping Workshop, Helsinki, Finland, 1985

83. Keskiaho L, Knuutila S, Kaski U, Nuutila A, Pihko H, de la Chapelle A: The inheritance of fragile sites: apparent absence of FRA2B in the parents of two unrelated probands. Eighth International Human Gene Mapping Workshop, Helsinki, Finland, 1985

84. Borgström GH, Bloomfield CD, de la Chapelle A: Translocation 1;7 with resulting monosomy 7q and trisomy 1q: A common recurring abnormality in myelodysplastic syndromes. Eighth International Human Gene Mapping Workshop, Helsinki, Finland, 1985

85. Bloomfield CD, Garson OM, Volin L, Knuutila S, de la Chapelle A: The t(1;3)(p36;q21) in acute nonlymphocytic leukemia (ANLL): a new cytogenetic-clinicopathologic association. Eighth International Human Gene Mapping Workshop, Helsinki, Finland, 1985

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86. Vergnaud G, Page D, Simmler MC, Rouyer F, Noel B, Botstein D, de la Chapelle A, Weissenbach J: The male determining region of the human Y chromosome: deletion mapping by DNA hybridization. Eighth International Human Gene Mapping Workshop, Helsinki, Finland, 1985

87. Kere J, Ruutu T, de la Chapelle A: Characterization of neoplasia-associated chromosome abnormalities by Southern blot analysis. Fourth Nordic Conference on Medical Genetics, Oslo, Norway, 1986

88. Lindlöf M, Kääriäinen H, de la Chapelle A: RFLP studies in families with Duchenne muscular dystrophy. Fourth Nordic Conference on Medical Genetics, Oslo, Norway, 1986

89. Sankila E-M, Karma J, Forces H, Eriksson A, de la Chapelle A: Linkage studies on choroideremia. Fourth Nordic Conference on Medical Genetics, Oslo, Norway, 1986

90. Peltomäki P, Knuutila S, Ritvanen A, Kaitila I, de la Chapelle A: Pallister-Killian syndrome: cytogenetic and molecular studies. 7th Int Congr Hum Genet, Berlin, Germany, 1986

91. Andersson M, Page DC, de la Chapelle A: Chromosome Y-specific DNA is transferred to the X-chromosome short arm in human XX males. 7th Int Congr Hum Genet, Berlin, Germany, 1986

92. Keinänen M, Knuutila S, Bloomfield CD, Elonen E, de la Chapelle A: The proportion of mitoses in different cell lineages changes during culture of normal bone marrow. 7th Int Congr Hum Genet, Berlin, Germany, 1986

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93. Kere J, Ruutu T, de la Chapelle A: Assignment to cell lineage and characterization of chromosomal abnormalities by RFLP analysis in hematological disorders. 7th Int Congr Hum Genet, Berlin, Germany, 1986

94. Lakkala-Paranko T, Franssila K, Lappalainen K, Leskinen R, Knuutila S, de la Chapelle A, Bloomfield CD: Non-random chromosome abnormalities in peripheral T-cell lymphomas. 7th Int Congr Hum Genet, Berlin, Germany, 1986

95. MacDermot KD, Malcolm S, Clark RP, Goff MR, Kaitila I, Airenne P, Söderholm AL, de la Chapelle A: Gene localisation for X linked hypohidrotic ectodermal dysplasia (Christ-Siemen-Touraine syndrome) and a novel noninvasive body sweat pore count method for detection of heterozygous females. 7th Int Congr Hum Genet, Berlin, Germany, 1986

96. Sankila E-M, de la Chapelle A, Kärnä J, Eriksson AW, Forsius H: Choroideremia: Close linkage to DXYS1 demonstrated by segregation analysis and genealogic evidence. 7th Int Congr Hum Genet, Berlin, Germany, 1986

97. Vauhkonen A-E, Rasi V, de la Chapelle A: First experiences of carrier detection by DNA analysis in hemophilia A and B in Finland. 7th Int Congr Hum Genet, Berlin, Germany, 1986

98. Lindlöf M, Kääriäinen H, de la Chapelle A: Carrier detection, genetic counseling and prenatal diagnosis in X-linked muscular dystrophy. Experience with presently available probes. 7th Int Congr Hum Genet, Berlin, Germany, 1986

99. de la Chapelle A: Morphological, immunological and molecular characterization of bone marrow and blood mitoses. Meeting on Molecular Genetics and Cytogenetics of Human Neoplasia, Berlin, Germany, 1986

100. Keinänen M, Knuutila S, Bloomfield CD, Elonen E, de la Chapelle A: The proportion of mitoses in different cell lineages changes during culture of normal bone marrow. Meeting on Molecular Genetics and Cytogenetics of Human Neoplasia, Berlin, Germany, 1986

101. Kere J, Ruutu T, de la Chapelle A: Assignment to cell lineage and characterization of chromosomal abnormalities by RFLP analysis in hematological disorders. Meeting on Molecular Genetics and Cytogenetics of Human Neoplasia, Berlin, Germany, 1986

102. Lindlöf M, Kääriäinen H, de la Chapelle A: RFLP studies in X-linked muscular dystrophy (XLMD): Carrier detection, prenatal diagnosis and linkage data. Satellite Workshop on New Techniques and Approaches to the Molecular Study of Human Inherited Disease, Genoa, Italy, 1986

103. Vauhkonen A-E, Rasi V, de la Chapelle A: DNA-diagnostik av hemofili. 19. Nordiska Koagulationsmötet, 1986

104. Page DC, Brown L, de la Chapelle A, Disteche C, McGillivray B, Simpson E: Sex reversal and the male-determining function of the human Y chromosome. Annual Meeting, American Society of Human Genetics, USA, 1986

105. MacDermot KD, Malcolm S, Clark RP, Goff MR, Kaitila I, Airenne P, Söderholm A-L, de la Chapelle A: X linked hypohidrotic ectodermal dysplasia. Gene localisation and a new method of sweat pore detection in heterozygous females by infra-red scanner. Greenwood Genetic Center, USA, 1987

106. Page DC, Brown L, Pollack J, Bieker K, de la Chapelle A, Disteche C, McGillivrey B: Sex reversal and the male-determining function of the human Y chromosome. British Society for Developmental Biology, Spring Meeting, Oxford, England, 1987

107. de la Chapelle A: Genes on the X and Y chromosomes: Phenotypic correlations. British Society for Developmental Biology. Spring Meeting, Oxford, England, 1987

108. MacDermot KD, Morgan SH, Cheshire JK, Wilson TM, Kaitila I, Söderholm A-L, de la Chapelle A, Kolvraa S, Bolund L, Kruse TA: X-linked anhidrotic ectodermal dysplasia (EDA). Two point and multipoint linkage analysis using 7 polymorphic DNA markers. Ninth International Human Gene Mapping Workshop, Paris, France, 1987

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109. Kere J, Savilahti E, Norio R, de la Chapelle A: Distribution of closely linked restriction fragment length polymorphism alleles in Finnish cystic fibrosis patients and parents. 15th Annual Meeting of the European Working Group for Cystic Fibrosis, Oslo, Norway, 1987

110. Sankila E-M, Page DC, de la Chapelle A: Orientation and gene order around the choroideremia locus. Ninth International Human Gene Mapping Workshop, Paris, France, 1987

111. Sankila E-M, Page DC, Forsius H, Kärnä J, Eriksson A, de la Chapelle A: Haplotyping Finnish choroideremia patients. Ninth International Human Gene Mapping Workshop, Paris, France, 1987

112. Kere J, Ruutu T, de la Chapelle A: Characterization of chromosome 7 long arm deletions by DNA probes in myeloid disorders. Ninth International Human Gene Mapping Workshop, Paris, France, 1987

113. Lehesjoki A-E, Rasi V, de la Chapelle A: Linkage analysis of two RFLPs closely linked to the F8C gene. Ninth International Human Gene Mapping Workshop, Paris, France, 1987

114. Andersson M, Page DC, Pettay D, Subrt I, Turleau C, de Grouchy J, de la Chapelle A: Y;autosome translocations and mosaicism in the etiology of 45,X maleness. Ninth International Human Gene Mapping Workshop, Paris, France, 1987

115. Lindlöf M, Sistonen P, de la Chapelle A: Linkage studies in X linked muscular dystrophy using gene specific and flanking DNA markers. Ninth International Human Gene Mapping Workshop, Paris, France, 1987

116. Alitalo T, Kärnä J, Forsius H, Frants R, Eriksson A, de la Chapelle A: Linkage studies in X-linked retinoschisis using eight polymorphic DNA probes from the short arm of X chromosome. Ninth International Human Gene Mapping Workshop, Paris, France, 1987

117. Alitalo T, Dobbs M, Wasmuth J, Kurnit D, de la Chapelle A: Mapping of six single copy DNA sequences on human chromosome 5 by in situ hybridization. Ninth International Human Gene Mapping Workshop, Paris, France, 1987

118. Saviranta P, Lindlöf M, Lehesjoki A-E, Kalimo H, Lang H, Sonninen V, Savontaus M-L, de la Chapelle A: Linkage studies in a new X-linked myopathy suggest exclusion of DMD locus and tentative assignment to distal Xq. Ninth International Human Gene Mapping Workshop, Paris, France, 1987

119. de la Chapelle A: Evidence for the existence of an autosomal testis determining gene, TDFA. Ninth International Human Gene Mapping Workshop, Paris, France, 1987

120. de la Chapelle A: Why sex chromatin screening for gender identification of female athletes should be dropped. 38th Annual Meeting, American Society of Human Genetics, San Diego, CA, USA, 1987

121. Breakefield XO, Sims KB, Norio R, Ozelius L, Hsu Y-PP, Sankila E, Powell JF, Corey T, Bruns G, Haines J, Gusella JF, Murphy D, de la Chapelle A: X-linked monoamino oxidase deficiency in humans. Annual Meeting, American Society of Human Genetics, New Orleans, Louisiana, USA, 1988

122. Disteche CM, de la Chapelle A, Green P, Adler DA, Page DC: Regional localization of the Zfx gene in mouse and of the ZFX gene in human. Tenth International Human Gene Mapping Workshop, New Haven, Connecticut, USA, 1989

123. Kere J, Donis-Keller H, Ruutu T, de la Chapelle A: Chromosome 7 long arm deletions in myeloid disorders: terminal DNA sequences are commonly conserved and breakpoints vary. Tenth International Human Gene Mapping Workshop, New Haven Connecticut, USA, 1989

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124. Alitalo T, Forsius H, Kärnä J, Eriksson AW, Kruse TA, de la Chapelle A: Additional linkage data and gene order around the locus for X-linked retinoschisis. Tenth International Human Gene Mapping Workshop, New Haven, Connecticut, USA, 1989

125. Alitalo T, Koistinen R, Aalto-Setälä K, Kontula K, Julkunen M, Jänne O, de la Chapelle A: Gene for the human insulin-like growth factor-binding protein/placental protein 12: mapping to 7p12-p14 and demonstration of a BglII RFLP. Tenth International Human Gene Mapping Workshop, New Haven, Connecticut, USA, 1989

126. Lehesjoki A-E, Sistonen P, Rasi V, de la Chapelle A: Linkage and gene order studies in hemophilia A. Tenth International Human Gene Mapping Workshop, New Haven, Connecticut, USA, 1989


127. Sankila EM, Lehner T, Eriksson AW, Forsius H, Kärnä J, Page DC, Ott J, de la Chapelle A: Multipoint linkage analysis in Finnish choroideremia families. Tenth International Human Gene Mapping Workshop, New Haven, Connecticut, USA, 1989

128. Kere J, Donis-Keller H, de la Chapelle A: Refinement of the map around the collagen locus in chromosome 7 by physical mapping. Tenth International Human Gene Mapping Workshop, New Haven, Connecticut, USA, 1989

129. Kere J, Ruutu T, Donis-Keller H, de la Chapelle A: Molecular mapping of long arm deletions of chromosome 7 in acute myeloid leukemia and myelodysplastic syndrome. Tenth International Human Gene Mapping Workshop, New Haven, Connecticut, USA, 1989

130. Kruse TA, Kolvraa S, Bolund L, Kaitila I, Söderholm AL, de la Chapelle A, MacDermot KD: X-linked anhidrotic ectodermal dysplasia (EDA). Multipoint linkage analysis. Tenth International Human Gene Mapping Workshop, New Haven, Connecticut, USA, 1989

131. Rouyer F, Weissenbach J, Andersson M, de la Chapelle A: An interspersed repeated element specific for subtelomeric regions. Tenth International Human Gene Mapping Workshop, New Haven, Connecticut, USA, 1989

133. Lehesjoki A-E, Sistonen P, Rasi V, de la Chapelle A: Hemophilia A: genetic prediction and linkage studies in Finish families. Annual Meeting, American Society of Human Genetics, Baltimore, Maryland, USA, 1989

134. Levinson B, Lehesjoki A-E, de la Chapelle A, Gitschier J: Molecular analysis of hemophilia A mutation in the Finnish population. Annual Meeting, American Society of Human Genetics, Baltimore, Maryland, USA, 1989

Discontinued in 1990

45


Rev. 07/08/08

46

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