CV Professor Peter GHOSH

Abridged CV – 03/07 – Peter Ghosh

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Professor Peter GHOSH

Place and date of birth : London, United Kingdom. 4th August 1940

Nationality & marital status : Australian, Married

Present position and CEO and Director of Research,Institute of Nutraceutical Research,

contact details : PO Box 35,Brookvale, NSW 2100, AustraliaTelephone: 61-02-99058440Mobile: 0410246469Facsimile: 61-02-99058443E-mail: [email protected]

Other Current Appointments2006 - Vice President, Cartilage Regenerative Programs, Mesoblast Ltd, Melbourne, Victoria 3000, Australia.2003 - Board Member, Institute of Bone and Joint Research, Royal North

Shore Hospital of Sydney, St Leonards, NSW 2065, Australia.2003 - Honorary Associate Professor, Faculty of Medicine, University of

Sydney, Australia.2003 - Honorary Member, Department of Orthopaedics, Royal North Shore

Hospital of Sydney, Australia.2003 - Board Member, Bone and Joint Research Foundation of the University

of Sydney, Australia.2005 - Chairman, Proteobioactives Pty Ltd, Brookvale, NSW 2100, Australia.2006 - Visiting Professor, Department of Biochemistry, Faculty of Medicine.

Chiang Mai University, Thailand.

Past Appointments1998/02 President, Institute of Bone and Joint Research, Royal North Shore

Hospital, St Leonards, NSW 2065, Australia.1986/02 Associate Professor, Department of Surgery, University of Sydney.1973/02 Academic Director, Raymond Purves Bone and Joint Research

Laboratories, University of Sydney.1978/79 Visiting Research Fellow, Dept. Pathology, University of British

Columbia, Vancouver, British Columbia, Canada.1969/70 Head of Department of Medicinal Chemistry, Riker Research Institute,

Sydney, Australia.1966/68 Research Fellow, John Curtin School of Medical Research, ANU

Canberra, Australia.1963/66 PhD Studentship, University of East Anglia, Norwich, Norfolk, UK1962/63 Research Scientist, Koch-Light Laboratories, Haverhill, Suffolk, UKAcademic Qualifications1962 Bachelor of Science, BSc (Honours) (Kings College, University of London, UK)1966 Doctor of Philosophy, PhD (University of East Anglia, Norwich, UK)1975 Fellow Royal Australian Chemical Institute, FRACI (Australia)1989 Fellow Royal Society of Chemistry, FRSC (UK)1989 Chartered Chemist, CChem (UK)

Abridged CV 03/07- Peter Ghosh

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1995 Doctor of Science, DSc (University of Sydney, Australia)2004 Chartered Scientist, CSc (UK)

Major honorary positions held in scientific societies and other professionalorganisations1978/80 Australian Director, International Foundation for Cancer Research

(Bethesda, USA)1976/83 Treasurer, Connective Tissue Society of Australia and New Zealand1982 Specialist Colloquia Organiser, 12th International Congress of Biochemistry,

Perth, WA1982/95 Scientific advisory committee.Osteogenesis Imperfecta Society of NSW1983/90 Board Member, SpineCare/Children's Spinal Research Foundation1983/85 President, Connective Tissue Society of Australia and New Zealand1984 Co-convenor, Australian Orthopaedic Association Continuing Education

Program (Basic Science)1984/85 Member, Scientific Advisory Committee - International League Against

Rheumatism (ILAR) Meeting, Sydney1984/85 Convenor, International League Against Rheumatism Satellite Meeting,

"Recent advances in connective tissue research", Port Stephens1988 Chairman, Organizing and Program Committee, Pan-Pacific Connective

Tissue Societies Meeting, Cairns, Qld1989 Member, International Working Party on Osteoarthritis, Cincinnati, Ohio,

USA1990 Member, International Working Party on Osteoarthritis, Val-David,

Quebec, Canada1990 Member, Executive Committee - Australasian & New Zealand

Orthopaedic Research Society1991 Founding Member, Osteoarthritis Research Society (Paris, France)1992/94 President, Australian and New Zealand Orthopaedic Research Society1993 Member Scientific Committee (Osteoarthritis), International League

Against Rheumatism Congress, Barcelona, Spain1993 Member, International Scientific Advisory Board - Vth Prague

Rheumatological Symposium, Czechoslovakia1993/95 Deputy Director, Science Council, RNSH1994 Member, Organising Committee - University of Sydney Orthopaedic Silver

Jubilee/Australian and New Zealand Orthopaedic Research Society Meeting,Sydney

1994/96 Chairman, Medical Research Council Sub-committee, RNSH1994/96 Member, Scientific Advisory Committee (Osteoarthritis and Cartilage) and

Symposia Executive Committee - Asia Pacific League AgainstRheumatism (APLAR) Congress, Melbourne, Vic.

1995/99 Academic Director, Bone and Joint Research Foundation1995 Chairman, Organising Committee - Matrix Biology Society of Australia

and New Zealand/Federation of Asia and Oceania Biochemist andMolecular Biologist Satellite Meeting, Terrigal

1995/02 Co-Chair, Post-graduate student review committee, Dept Surgery1996 Member, Scientific Advisory Committee, European Society for

Osteoarthrology, Ghent, Belgium1996/97 Co-chairman, Scientific Program Director - Osteoarthritis Research

Society / International League Against Rheumatism Conjoint Meeting,Singapore


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1997/02 Board Member, Osteoarthritis Research Society International (OARSI)1997 Board Member, Northern Medical Research Foundation1997/00 Member, RNSH Medical Research Committee1998 Chairman, Scientific Program Committee, Association Research

Circulation Osseous (ARCO), SICOT meeting, Darling Harbour, Sydney1999 Scientific Advisory Committee, Pan-Pacific Connective Tissue Societies

Meeting, Queenstown, NZ1999/00 Member, Scientific Program Committee, Cartilage Products Technology,

Banff, Canada2001/02 Chair, Scientific Program committee OARSI International OA Congress,

Sydney,2001/03 Member, Australian National Action Network Committee, Bone and Joint

Decade2001/05 Member Stryker Biotech, scientific advisory committee, Sydney2002/03 Member, Lincoln Foundation Scientific Advisory Committee, Sydney

Prizes and AwardsSmith and Nephew, Australian Spinal Research Prize (1997) (with Melrose J andTaylor TKF).European Spinal Research Society Award for best paper 2002-3(with Shen B, Taylor TKF and Melrose J).Elected Life Member, International Society for Hyaluronan Sciences (USA) (2004)Charles R Ream Award for research excellence(Current Therapeutic Research Publication) (2005) (with Edelman J, March L andSmith M).

Editorial Boards/Journal Reviewer (1985 – present)Current Rheumatology Reviews (Editorial Board)Osteoarthritis and Cartilage (Editorial Board)APLAR Journal of Rheumatology (Editorial Board)Arthritis and Rheumatism (Reviewer)Annals of Rheumatic Diseases (Reviewer)Journal of Orthopaedic Research (Reviewer)Journal of Rheumatology (Reviewer)Spine (Reviewer)Seminars in Arthritis and Rheumatism (Reviewer)

Scientific Assessor Major Grants (1980 – 2002):National Health & Medical Research CouncilHealth Research Council of New Zealand (committee)Health Research Council of Hong KongArthritis Foundation of CanadaARGC, ARA, AOA, ARA (Australia)Wellcome Foundation (UK)US-Israel Binational Science Foundation (USA)

Invitations to present lectures or chair national or international scientificmeetings / congresses:

1974 - 19801. "Articular Cartilage" Symposium. Organised by the Institute of Postgraduate

Studies, University of London, UK, 1974 (Invited Speaker and Participant).


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2. South East Asia and Pacific Area League (SEAPAL), 3rd RheumatologySymposium. Canberra, ACT, 1977 (Invited Speaker).

3. Symposium: "The Aetiopathogenesis of Osteoarthrosis". (Arthritis andRheumatism Council, UK), Cardiff, UK, 1977 (Invited Speaker)

4. 11th Congress of International Association of Gerontology - Satellite Meeting"Ageing in Australia". Sydney, NSW, 1978 (Invited Speaker).

5. Osteoarthrosis Workshop (Institute of Postgraduate Studies), University ofLondon, UK, 1979 (Invited Speaker and Participant).

1980 - 19856. SEAPAL, 4th Rheumatology Congress. Manila, Philippines, 1980 (Invited

Speaker).

7. International Symposium: "Osteoarthritis and Inflammation". Organised by theUniversity of Miami, School of Medicine, Palm Aire, Florida, USA, 1981 (InvitedSpeaker and Participant).

8. International Union of Biochemistry Congress - Workshops on "Matrix Biology".Perth, WA, 1982 (Chairman and Invited Speaker).

9. International Union of Biochemistry Congress - Satellite Meeting: "Connectivetissue in health and disease". Monash University, Vic, 1982 (Invited Chairmanand Speaker).

10. Western Pacific Connective Tissue Societies Meeting. St. George, Utah, USA,1983 (Invited Speaker).

11. SEAPAL, 5th Rheumatology Congress. Bangkok, Thailand, 1984 (InvitedSpeaker).

12. Pan-Pacific 17th Surgical Congress. Sydney, NSW, 1984 (Invited Speaker).

13. Inaugural Gordon Research Conference on "Proteoglycans". Plymouth, NewHampshire, USA, 11-15 June 1984 (Invited Participant).

14. XVI International Congress in Rheumatology (ILAR). Sydney, NSW, 1985.(Chairman of two Sessions, one Workshop and Review Speaker in twoSessions) (Member of the Scientific Advisory Board).

15. International Symposium: "Recent Advances in Connective Tissue Research".International League Against Rheumatism Satellite Meeting, Port Stephens,NSW, May 1985. (Chairman and Speaker).

16. NH & MRC Special Workshop: "Ageing Research in Australia". University ofNew South Wales, NSW, August 1985 (Invited Speaker and Discussant).

1986 - 199017. International Symposium: "Proteases and Their Involvement in the

Pathogenesis of Osteoarthritis". Val David, Quebec, Canada, August 1986(Invited Speaker).


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18. Prince Henry's Hospital, Melbourne, Victoria. Symposium: "The Challenge ofOsteoarthritis". (Sponsored by Ciba-Geigy), August 1986 (Invited ReviewLecturer).

19. New Zealand Rheumatism Association Symposium: "Cartilage Science inArthritis". Auckland, NZ, March 1987 (Invited Speaker).

20. Special Lecture Tour of New Zealand (Auckland, Hamilton, Christchurch,Dunedin): "The Etiopathogenesis of OA and a Rational Approach to itsTreatment". Sponsored by Roussel (NZ), July 1987.

21. Inaugural Postgraduate Medical Research Symposia: "Recent Advances inOrthopaedic Research". Department of Orthopaedics, National University ofSingapore, 12-23 July 1987 (Visiting Professor and Lecturer).

22. Symposium: "The Aetiopathogenesis of Osteoarthritis". The Institute ofOrthopaedics, University of London, UK, September 1987 (Invited Participantand Speaker).

23. Symposium: "The Lumbar Disc". Combined Meeting - Australian SpinalResearch Society and Australian Association of Musculoskeletal Medicine.Brisbane, Qld, October 1987 (Invited Speaker).

24. German Drug Regulatory Authority (Bundesgesund heits - amt. BGA).European Inquiry into "Chondroprotective Drugs". Berlin, Germany, 9 May 1988(Invited Expert Witness).

25. Annual Meeting of the Japanese Orthopaedic Association. Tokyo, Japan,September 1988 (Invited Guest Lecturer and Participant).

26. Sociedade Brasileira de Reumatogia XVII Congress. Florianopolis, Brazil, 25-29September 1988 (Invited Guest Lecturer - two lectures).

27. SEAPAL Symposium: "Therapeutic (NSAIDs) Modulation of CartilageCatabolism in Arthritis". Tokyo, Japan, 9 September 1988 (Chairman andSpeaker).

28. "Recent Advances in Cartilage Research". Inaugural Geigy RheumatologySymposium. Melbourne, Vic, November 1988 (Invited Speaker).

29. American College of Rheumatology Satellite Meeting: "Cartilage Degradation, isthere a Place for Chondroprotective Agents?" Cincinnati, USA, 17 June 1989(Chairman and Speaker).

30. Geigy Rheumatology Symposium "Osteoarthritis". Surfers Paradise, Qld, 22-22October 1989 (Chairman - Round-table Discussant).

31. Inaugural Pan-Pacific Connective Tissue Societies Symposium. Cairns, Qld,5-10 November 1989 (Chairman, Speaker and Chairman of Program).

32. Japanese Connective Tissue Annual Society Meeting: "Role of MechanicalFactors in the Metabolism of Cartilage". Tokyo, Japan, 21-23 February 1990(Invited Lecturer).


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33. Symposium: "Synovium-cartilage Inter-relationships, Physiology and Pathologyin Osteoarthritis". 9th Centenary Foundation Meeting of the University ofBologna. Bologna, Italy, 21-24 May 1990 (Invited Speaker - two lectures).

34. Inaugural Combined Meeting of the Sydney Carbohydrate and Protein Groups.University of New South Wales, NSW, July 1990 (Review Lecturer).

35. Combined Meeting of the New Zealand Rheumatism and AustralianRheumatism Association Meeting. Queenstown, NZ, September 1990 (InvitedChairman).

36. First International Symposium and Workshop on the "Synovium". University ofPennsylvania, Philadelphia, PA, USA, September 1990 (Invited Speaker).

37. Osteoarthritis Symposium: "Diagnosis and Therapy". La Sapiniére, Val-David,Quebec, Canada, 3-5 October 1990 (Invited Speaker).

1991 - 199538. Fidia Research Symposium: "Laboratory Evaluation and Development of

Chondroprotective Agents". Albano Terme, Italy, 25 June 1991 (Invited Lecturerand Workshop Chairman).

39. European League Against Rheumatology (EULAR) Osteoarthritis Symposium.Budapest, Hungary, 30 June - 7 July 1991 (Invited Speaker).

40. Inaugural Meeting of the Orthopaedic Research Society of Australia and NewZealand. Christchurch, NZ, 18 August 1991 (Speaker and Chairman).

41. 11th Congress of the Asian Orthopaedic Association. Kuala Lumpur, Malaysia,21-23 November 1991 (Invited Speaker and Chairman).

42. Ciba-Geigy Cartilage Symposium in conjunction with Australian RheumatologyAssociation Meeting. Perth, WA, 1-4 December 1991 (Co-chairman andSpeaker).

43. Australian Society for Medical Research National Meeting, Canberra, ACT,17 December 1991 (Invited Speaker).

44. 10th Congress of the Italian Arthroscopy Society Symposium: "Focus onArthroscopic Approach to the Diagnosis and Follow-up of Osteoarthritis of theKnee". 19-22 January 1992. Cortina d'Ampezzo, Italy (Invited Speaker andWorkshop Participant).

45. 19th Congress of the European Society of Osteology (ESOA). Noordwijkerhout,Netherlands, May 1992 (Plenary Lecturer).

46. The Spinal Society of Australia Meeting. Adelaide, SA, August 1992 (InvitedSpeaker).

47. 7th Asia Pacific League Against Rheumatology (APLAR) Congress. Bali,Indonesia, 13-18 September 1992 (Invited Congress Lecturer).

48. 1st Congress of the Osteoarthritis Research Society: "The Regulation ofCartilage Metabolism in OA". 10-12 December 1992, Paris, France (Speakerand Chairman of Session 3) (Invited to become Member of Editorial Board).


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49. Workshop: "Pathology and Physiology of Osteoarthritis" Symposium. Universityof Cologn, Germany, 13-14 December 1992 (Invited Speaker) (2 papers).

50. Special Invited Lecture: "New Horizons in Osteoarthritis Research". Universityof Padua, Italy, December 1992 (Visiting Professor).

51. 39th Meeting of the Orthopaedic Research Society (USA). February 1993(Chairman of Cytokines Session).

52. International League Against Rheumatism (ILAR) XVIII Congress, Barcelona,Spain, July 1993 (Invited Scientific Adviser also)

53. Congress Symposium - Session - "Osteoarthritis, Sulphated and Non-sulphatedDrug Therapy" (Review Speaker).

54. Symposium - Osteoarthritis: "New Perspective in Disease Modification" (InvitedSpeaker).

55. Workshop - Osteoarthritis: "New Understandings" (Invited Speaker andDiscussant).

56. Vth Prague Rheumatology Symposium, Czechoslovakia. September 1993(Plenary Lecture and Member of Scientific Advisory Committee - DiseaseModification in Osteoarthritis).

57. 2nd Pan-Pacific Connective Tissue Societies Symposium. September 1993,Bali, Indonesia, (Invited Lecture: "Pathobiology of Osteoarthritis" and Chairmanof Session).

58. Royal Swedish Academy of Science. Invited member of Australian delegation tovisit Swedish universities and present lectures. Speaker at a SpecialSymposium on "Matrix Biology". 23-27 September 1993, Medevi Brunn,Sweden.

59. Australian Orthopaedic Association Annual Meeting and Australia New ZealandOrthopaedic Research Society combined plenary session. (Chairman andReview Lecture: session 4 - "The Role of Mechanical Factors on theMetabolism of Disc Proteoglycans"). Adelaide, SA, 30 September 1993.

60. Japanese Rheumatism Foundation. 3rd International Symposium on the"Treatment of Osteoarthritis with Slow Acting Anti-rheumatic Drugs". Tokyo,Japan, 5 March 1994 (Invited Lecturer).

61. Spinal Research Society of Australia - Smith and Nephew Research PrizeAward (in conjunction with Professor TKF Taylor and Dr. J Melrose). RACS,Melbourne, Vic, 1994.

62. XVI International Congress of Biochemistry, Satellite Symposium on "Collagen".Madras, India, 15-17 September 1994 (Invited Chairman and Speaker).

63. International Symposium: "Osteoarthritis: Challenges for the 21st Century". LaSapiniére, Quebec, Canada, 5-7 October 1994 (Invited Speaker).

64. Connective Tissue Society of Australia and New Zealand. Warburton, Vic,December 1994 (Chairman).


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65. International Expert Workshop on "Hyaluronic Acid" (Bayer AG, sponsor).Rathaus Schönenberg, John F. Kennedy Platz, Berlin, Germany, 27-29 January1995 (Invited Speaker and Workshop Participant).

66. Visiting Professor and Lecturer: "The Role of Mechanical Factors and TGF-b onCartilage Metabolism". University of Caen, Normandy, France, 31 January1995.

67. Symposium: "Inflammation and the Extracellular Matrix". Sponsored by theRebecca L. Cooper Medical Research Foundation. Sydney, NSW, 11-12 May1995 (Invited Speaker).

68. Combined New Zealand and Australian Rheumatology Association Meeting.Auckland, NZ, 14-17 May 1995 (Invited Speaker).

69. XII European Congress of Rheumatology. Amsterdam, Netherlands, 18-23 June1995 (Invited Speaker).

70. Australian Association of Musculoskeletal Medicine Annual Conference.Canberra, ACT, 22-23 July 1995 (Invited Speaker).

71. Australian and New Zealand Orthopaedic Association Annual Meeting.Melbourne, Vic, September 1995 (Chairman).

72. 7th International Seminar on "The Treatment of Rheumatic Diseases". Tel-Aviv,Israel, 1-16 December 1995 (Invited Speaker).

199673. 9th Annual Meeting Japanese Society of Cartilage Metabolism. Nagoya

University, Japan, 29 February - 2 March 1996.

Invited Speaker:(a) Symposium: Novel concepts of osteoarthritis (29.2.96)(b) Professor Shinmei Memorial Lecture (2.3.96)

74. 8th Asia Pacific League Against Rheumatism Congress of Rheumatology.Melbourne, Vic, 21-26 April 1996.

Invited Speaker and/or chairman:(a) "Cartilage Structure and Function in Osteoarthritis" (23.4.96)(b) Seikagaku Symposium: "Hyaluronan and the Biochemical Lesions of

Osteoarthritis" (23.4.96)(c) Arthropharm Symposium: "Sites and Modes of Action of Polysulphate

Polysaccharides in Osteoarthritis" (24.4.96)(d) Continuing Orthopaedic Education Workshop: "Physiological

Treatments of Arthritis" (26.4.96)

Annual Scientific Meeting Royal Australasian College of Physicians.Canberra, ACT, 7-10 May 1996. Invited Lecture: "Disc Metabolism".


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75. Workshop: "Osteoarthritis Clinical Trials". (Combined meeting of OARSTaskforce, GREES, OMERACT III). Washington, DC, USA, 25-27 May 1996(Invited Workshop Participant).

76. 21st Symposium of the European Society for Osteoarthrology. Ghent, Belgium,25-28 September 1996 (Invited Lecturer and Member of Scientific AdvisoryCommittee).

77. Australian Society for Experimental Pathology Annual Scientific Meeting.University of New South Wales, NSW, 7-11 October 1996 (Invited Lecture - TheBoehringer Lecture).

78. 3rd Pan-Pacific Connective Tissue Societies Symposium. Kamuela, Hawaii,USA, 20 November - 5 December 1996 (Chairman - Session: ECM of Bone andCartilage).

79. 7th International Symposium on "Bone Necrosis". Fukuoka, Japan, 3-5 October1996 (Invited Participant / Speaker).

80. ASEAN / Indonesian Orthopaedic Association Meeting, Bali, Indonesia,11-13 November 1996 (Plenary Lecturer).

199781. Combined Osteoarthritis Society and International League Against Rheumatism

(ILAR) Congress, Singapore, June 1997 (Chairman and Invited Speaker) (Co-chair Scientific Program and Organising Committee).

82. New Zealand Musculoskeletal Research Society Annual Meeting, Auckland,New Zealand, August 1997 (Invited Speaker).

83. Japanese Arthritis Society Annual Meeting, Nagota, Japan, 17-18 October 1997(Invited Speaker).

199884. Combined Meeting of the 5th Rheumatism Association of ASEAN (RAA) and

3rd Asia-Pacific League of Associations for Rheumatology (APLAR) Congress,Manila, Philippines, 18-22 January 1998 (Invited Plenary Lecturer, SymposiumLecturer and Chairman).

85. 5th International Congress “Research and Therapeutics in Osteoarthritis:Interleukin-1 Inhibitors”. La Napoule, France, 31 January - 1 February 1998(Invited Speaker).

86. Australian Rheumatology Association Scientific Meeting, Sydney, NSW, May1998 (Symposium Lecturer - “Osteoarthritis, Pathogenesis and Treatment”).

87. AVS Satellite Meeting on NSAIDs and OA. Darling Harbour, 19 May 1998. (TwoLectures on OA and NSAID treatment).

88. UCB Conference on Osteoarthritis. New York, USA, 23 May 1998. (Lecture“Animal Models of OA”).

89. “New Frontiers in Joint Arthroplasty” St. George Hospital, Kogarah, NSW,21 August 1998. Lecture “Cartilage Metabolism in OA”.


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90. 13th Annual Japanese Orthopaedic Research Society (JORS) Meeting,Nagoya, 25-27 September 1998. Two lectures: (a)Pathogenesis of Disc Degeneration and Future Therapies.

(b) Biomechanical and Ultrastructure Changes in Cartilage in EarlyTraumatic Arthritis. (Invited Speaker).

91. Osteoarthritis Research Society, “Role of Nitric Oxide and Cycloxygenase inOsteoarthritis”, Florence, Italy, 15-16 October 1998 (Chairman of Session 3)

199992. Société Internationale de Chirurgie Orthopédique et de Traumatologie (SICOT),

21st World Congress, Sydney, Australia, 18-23 April 1999 (Invited SymposiumSpeaker - “Pathogenesis and Treatment of Osteoarthritis”).

93. 4th World Congress on Osteoarthritis and Satellite Symposia - OsteoArthritisResearch Society International, Vienna, Austria, 16-19 September 1999 (InvitedSpeaker and Chairman).

94. 4th Pan-Pacific Connective Tissue Society Meeting, Queenstown, NZ,November 1999 (Invited Speaker and Chairman).

200095. SA Australian Rheumatology Association (Meeting), Adelaide, SA, Australia,

23 February 2000 (Invited Speaker).

96. The First International Symposium on Antler Science and Product Technology,Banff, Alberta, Canada, 9-12 April 2000 (Invited Speaker and Chairman).

97. 9th APLAR Congress and 6th Chinese Rheumatology Association, Beijing,China, 21-26 May 2000 (Invited Speaker and Chairman).

200198. Invited Workshop Participant: "The Role of Bone in Osteoarthritis". Procter and

Gamble Symposium, Coral Gables, Miami, Florida, USA, 9-11 February 2001.

99. Australian Society for Cellular and Molecular Gerontology, "Osteoarthritis,Genetic and Molecular Mechanisms". Melbourne, Vic, 19-22 March 2001 (GuestSpeaker).

100. Symposium EULAR 2001 Meeting, "Mechanism of Action of Hyaluronan inOsteoarthritis". Prague, Czech Republic, 13-16 June 2001 (Review Lecture).

101. 6th World Congress on Osteoarthritis and Satellite Symposia - OsteoArthritisResearch Society International, Washington, DC, USA, 30 September-3October 2001 (Invited Chairman).

102. Ghosh P: The challenges associated with the biologic repair of cartilagedefects. Institute of Bone and Joint Research Symposium, Sydney University,NSW, 24 November 2001.

2002103. McCraig Osteoarthritis Workshop, Emerald Lake, Alberta, Canada, 22-23 March

2002. (Invited Workshop Participant).


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104. OARSI Annual Congress, Sydney, NSW, 22-25 September 2002. (Chairman"Symposium 2: Integrative Medicine, A Maturing Science")

105. Asia Pacific Forum on New Therapeis in Rheumatic Disease, Singapore, 9-13October 2002. (Plenary Speaker and Symposium Participant).

106. Hong Kong Medical Association Meeting, “Etiopathogenesis of Osteoarthritisand New Strategies for its Treatment”. Hong Kong, 26 October 2002. (InvitedSpeaker).

107. APLAR Congress, Hyaluronan Satellite Meeting, Bangkok, Thailand, 1-6December 2002. (Invited Speaker)

2003108. Hyaluronan 2003 International Conference, Cleveland, Ohio, USA, October

2003. (Invited Session Chairman and speaker).

2004

International Cartilage Repair Society Congress, Ghent, Belgium, May, 2004,(Invited Plenary Lecturer).

Stryker Australia, Orthopaedic Symposium, Queenstown, New Zealand, July2004 (Invited basic science Lecturer).

2005Italian Rheumatology Association, 5th Annual Rheumatics Course: Cartilageand Bone Inter-relationships. Plenary Lecture, Physiology and Pathology inOsteoarthritis and Osteoporosis, Bologna, Italy, June 15-18, 2005 (invitedspeaker).

2006Japanese Rheumatology Association Congress, Nagasaki, Japan,April 21 –25th , 2006 (invited speaker).

Publications

(i) Editor Books / Monographs

1. Ghosh P (Guest Editor): Symposium: Recent advances in connective tissueresearch. Agents Actions Special 18 (Suppl.): 1986.

2. Ghosh P (Editor): Biology of the intervertebral disc. CRC Press, UnisciencePublication, Boca Raton, Fl, USA, (Vols. I and II) 1988.

3. Moskowitz R, Pavelka K, Ghosh P and Jubb RW: Intra-articular hyaluronans:A new direction in osteoarthritis therapy. A continuing Medical EducationProgram, Monograph, Case Western Reserve University School of Medicine,Cleveland, Ohio, USA, 2002.


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(ii) Chapters in Books

1. Boulton AJ and Ghosh P: Benzofuroxans in advances in heterocyclicchemistry. Academic Press, 10: 8-25, 1969.

2. Taylor TKF, Ghosh P, Bushell GR and Sutherland JM: Disc metabolism inscoliosis. Proc. 5th Symposium on: Scoliosis. The Cardiothoracic Institute,Brompton Hospital, London, 21-22 September 1976. Ed. PA Zorab. AcademicPress, London, New York and San Francisco, pp 231-246, 1977.

3. Ghosh P and Taylor TKF: Is primary osteoarthrosis the consequence ofageing? Proceedings of the Satellite Conference of the 11th Congress of theInternational Association of Gerontology, pp 110-112, Sydney, Australia, 1978.

4. Taylor TKF and Ghosh P: Ageing and the intervertebral disc. Proc. SatelliteConference of the 11th Congress of the International Association ofGerontology, pp 113-115, 1978.

5. Taylor TKF, Ghosh P, Bushell GR and Andrews JL: Glycosaminoglycans andcollagen in idiopathic scoliosis. 6th Symposium on: Scoliosis. Ed. PA Zorab,Academic Press, pp 179-193, 1980.

6. Ghosh P and Taylor TKF: The musculoskeletal system. In: Clinical science forsurgeons. Ed. W Burnett. Butterworths Press, London, UK, pp 449-478, March1981.

7. Taylor TKF, Ghosh P, Bushell GR and Stephens RW: Scientific basis for thetreatment of intervertebral disc disorders. In: Scientific Foundation ofOrthopaedic Surgery and Traumatology. Ed. R Owen, Heinemann Med. Books,UK, pp 387-405, 1981.

8. Ghosh P, Ternai B and Whitehouse B: Benzofurazans and benzofuroxans:Biochemical and Pharmacological Properties. Medicinal Research Reviews1(2): 159-187, 1981.

9. Burkhardt D and Ghosh P: Synergistic combinations of hyperthermia andinhibitors of nucleic acids and protein synthesis. In: Hyperthermia and cancertreatment. Eds. LJ Anghileri and J Robert, Chapter 7, CRC Press, Inc. USA,1(2): 127-157, 1984.

10. Ghosh P: Influence of Drugs and Hormones on disc metabolism and thesequelae of its degeneration. In: Biology of the Intervertebral Disc. Ed. PGhosh, Uniscience Series, Chapter 12, CRC Press, Inc, Boca Raton, Fl, USA,pp 121-159, 1988.

11. Melrose J and Ghosh P: Disc non-collagenous proteins including enzymes andtheir inhibitors. In: Biology of the Intervertebral Disc. Ed. P Ghosh, UniscienceSeries, Chapter 8, CRC Press, Inc, Boca Raton, Fl, USA, pp 189-237, 1988.

12. Ghosh P: Anti-rheumatic drugs and cartilage. In: Bailliere's ClinicalRheumatology, International Practice and Research. Ed. P Brooks, Tindall,Saunders, London, UK, pp 309-338, 1988.

13. Brooks P and Ghosh P: Chondroprotection, myth or reality. In: Controversies inRheumatology. Ed. N Bellamy, Bailliere Tindall, London, UK, (Vol. 4), pp 293-303, 1990.


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14. Ghosh P, Smith M and Wells C: Second line agents in osteoarthritis. In:Second Line Agents in the Treatment of Rheumatic Diseases. Eds. D Furst andJ Dixon. Chapter 15, Marcel Dekker, Inc, NY, pp 363-427, 1991.

15. Ghosh P: Future treatments of osteoarthritis. In: APLAR Rheumatology. Eds.Nasution AR, Darmawan J, Isbagio H. Churchill Livingstone NY, pp 255-258,1992.

16. Ghosh P, Numata Y, Smith S, Read R, Armstrong S, Johnson K: The metabolicresponse of articular cartilage to abnormal mechanical loading induced bymedial or lateral meniscectomy. Joint Destruction in Arthritis & Osteoarthritis.AAS 39: 89-93, 1993.

17. Ghosh P, Armstrong S, Read R, Numata Y, Smith S, McNair P and Marshall R:Animal models of early osteoarthritis: Their use for the evaluation of potentialchondroprotective agents. Joint Destruction in Arthritis & Osteoarthritis. AAS39: 195-206, 1993.

18. Little C and Ghosh P: Potential use of pentosan polysulphate for the treatmentof equine joint disease. In: Joint Disease in the Horse. Eds. CW McIlwraith andGW Trotter, Chapter 17. WB Saunders, 1996.

19. Ghosh P: Role of biomechanical factors. In: Experimental and Clinical Aspectsof Osteoarthritis. Eds. Reginster, Henrotin and Martel-Pelletier, Chapter 4.2,Springer-Verlag, Heidelberg, Germany, 1998.

20. Ghosh P, Roubin R and Smith MM: Rationale for the use of antler cartilageproducts and genes obtained from their cells to treat arthritis and repaircartilage defects following joint injury. In: Antler Science and ProductTechnology. Eds. Sim JS, Smith MM and Ghosh P: Experimental models ofosteoarthritis. In: Osteoarthritis. Diagnosis and Medical/Surgical Management(3rd Edition). Eds. Moskowitz RW, Howell DS, Altman RD, Buckwalter JA andGoldberg VM. Chapter 8, WB Saunders Company, Philadelphia, London, NewYork, St. Louis, Sydney, Toronto, pp 171-199, 2001.

21. Sunwoo HH, Hudson RJ and Jeon BT. Antler Science and Product TechnologyResearch Centre, University of Alberta, Edmonton, Canada. pp 296-313, 2001.


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22. Roubin R and Ghosh P: Deer antler cartilage cells express specific growthfactors which up-regulate chondrocyte DNA and proteoglycan biosynthesis invitro. In: Antler Science and Product Technology. Eds. Sim JS, Sunwoo HH,Hudson RJ and Jeon BT. Antler Science and Product Technology ResearchCentre, University of Alberta, Edmonton, Canada. pp 151-170, 2001.

23. Ghosh P and Cheras P: Vascular mechanism in osteoarthritis. In :Pharmacopathogenesis. Eds. Breedveld F and Brooks P. Bailliere's-ClinicalRheumatology - Best Practice and Research Clinical Rheumatology, 15(5):693-709, 2001.

24. Ghosh P: Prospects for pharmacological modification of joint breakdown inosteoarthritis: The biological perspectives. In: Osteoarthritis. (2nd Editions)Eds. Brandt K, Doherty M and Lohmander S. Oxford University Press, Chapter11.2.1. 4 April 2003.

25. Ghosh P, Smith M, Burkhardt D, Kepic B, Swain M, Cake M, Read RPreclinical studies on the pharmacology of Hyaluronan in relation to itsapplication as an intra-articular therapy for the treatment of osteoarthritis. inHyaluronan : structure, metabolism, biological activities, therapeuticapplications. Balazs EA and Hascall VC, Eds. Matrix Biology InstitutePublications, New Jersey, USA, Volume 2: 491 – 502, 2005.

26. Ghosh P: Systemic Chondroprotection, 5th International Cartilage RepairSociety, Ghent Meeting May 26-29, 2004. Medimond International ProceedingsPublications.

(iii) Short Articles, Communications in Refereed Journals

1. Taylor, TKF, Bushell GR and Ghosh P: School screening for scoliosis: APandora's box. Aust. N.Z. J. Surg. 48(1): 2-3, 1978.

2. Taylor TKF, Bushell GR and Ghosh P: School screening for scoliosis: A lookinside Pandora's box. Aust. N.Z. J. Surg. 48(4): 441-443, 1978.

3. Taylor TKF and Ghosh P: Tropical fruit in the treatment of lumbar discprolapse - A topical issue. Med. J. Aust. Editorial, 142(8): 462-464, 1985.

4. Taylor TKF and Ghosh P: Chemonucleolysis - Unexpected new horizons forresearch. Aust. N.Z. J. Surg. Editorial, 55: 88-90, 1985.

5. Ghosh P: Chondroprotective drugs and osteoarthritis. (Letter) Ann. Rheum.Dis. 49(5): 338-339, 1990.

6. Taylor TKF, Ghosh P and Melrose J: Chemonucleolysis - A further look at acontentious issue. Med. J. Aust. 153(10): 575-578, 1990.

7. Ghosh P, Holbert C, Read R, Armstrong S and Wilson D: Chondroprotectionand NSAIDs. (Letter). Lancet 337(8757): 1612-1613, 1991.

8. Ghosh P and Brooks P: Chondroprotection - Exploring the concept (Editorial).J. Rheumatol. 18(2): 161-166, 1991.

9. Ghosh P: Rheumatology of hyaluronan preparation - NRD 101 (A view point).Clinical Immunotherapeutics. (6)2: 169-170, 1996.


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10. Ghosh P: Point-of-View “Biomechanical effects of chondroitinase-ABC andchymopapain on spinal motion segment”. Spine 22(16): 1834-1835, 1997.

11. Ghosh P: Point-of-View “Matrix metalloproteinases: The clue to intervertebraldisc degeneration?” Spine 23(14): 1626, 1998.

12. Ghosh P: A review of the use of Adequan, Cartrophen and pentosan equinein the horse. Aust. Equine Vet. 18(1): 109-110, 2000.

13. Ghosh P and Smith M: Synovial ablation in a rabbit rheumatoid arthritis modelusing photodynamic therapy. Editorial. ANZ J. Surg. 72(7): 461, 2002.

(iv) Full-length Articles in Refereed Journals

1. Boulton AJ, Ghosh P and Katritzky AR: Eine allgemaine umlagerung vonHererocyclic und neue Synthesen des Benzotriazol-, Benzofurazan, undAnthranil-Systems. Ang. Chem. 816-817, 1964.

2. Boulton AJ, Ghosh P and Katritzky AR: N-oxides and related compounds.Part XXVIII. 5-Amino and 5-hydroxy benzofuroxans. J. Chem. Soc. (C): 971-976, 1966.

3. Boulton AJ, Ghosh P and Katritzky AR: Heterocyclic rearrangements. Part V.Rearrangement of 4-arylazo and 4-nitro-benzofuroxans: New syntheses of thebenzotriazole and benzofurazan ring systems. J. Chem. Soc. (B): 1004-1011,1966.

4. Boulton AJ, Ghosh P and Katritzky AR: Heterocyclic rearrangements. Part VI.Rearrangement of 4-acyl and 4-amino-alkyl benzofuroxans: New synthesis ofthe anthranil and indazole ring system. J. Chem. Soc. (B): 1011-1015, 1966.

5. Boulton AJ, Ghosh P and Katritzky AR: A new benxofurazan synthesis.Tetrahedron Lett. No. 25: 2887-2888, 1966.

6. Ghosh P: Preparation and study of some 5-, and 7-substituted-4-nitrobenzofurazans and their N-oxides: A retro-Boulton-Katritzkyrearrangement. J. Chem. Soc. (B): 334-342, 1968.

7. Ghosh PB and Whitehouse MW: Potential antileukemic andimmunosuppressive drugs. Preparation and in vitro pharmacological activityof some benzo-2,1,3-oxadiazoles (benzofurazans) and their N-oxides(benzofuroxans). J. Med. Chem. 11: 305-311, 1968.

8. Ghosh PB and Whitehouse MW: 4-Nitrobenzofurazans and 4-nitrobenzofuroxans: A new class of thiol neutralising agents and potentinhibitors of nucleic acid synthesis in leucocytes. Biochem. Pharmacol. 17:158-161, 1968.

9. Ghosh P and Whitehouse MW: 7-Chloro-4-nitrobenzo-2-oxa-1,3-diazole: Anew fluoroigenic reagent for amino acids and other amines. Biochem. J. 108:155-156, 1968.

10. Brown DJ and Ghosh PB: The spectra, ionization, and deuteriation ofoxazoles and related compounds. J. Chem. Soc. B: 270-276, 1969.

11. Ghosh P and Whitehouse MW: Potential antileukemic andimmunosuppressive drugs. II: Further studies with benzo-2,1,3-oxidiazoles


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(benzofurazans) and their N-oxides (benzofuroxans). J. Med. Chem. 12: 505-507, 1969.

12. Ghosh P: Oxadiazolobenzoxadiazole and thiadiazolobenzoxadiazole - Novelheterocyclic system. Tetrahedron Lett. No. 32: 2999-3000, 1971.

13. Ghosh PB, Ternai B and Whitehouse MW: Potential antileukemic andimmunosuppressive drugs. 3. Effects of homocyclic ring substitution on the invitro drug activity of 4-nitrobenzo-2,1,3-oxadiazoles (4-nitrobenzofurazans)and their N-oxides (4-nitrobenzofuroxans). J. Med. Chem. 15: 255-260, 1972.

14. Ghosh PB and Ternai B: The reaction of 4- and 5-acetyloxazoles withmalononitrile. J. Org. Chem. 37(7): 1047-1049, 1972.

15. Bolt AG, Ghosh PB and Sleigh MJ: Benzo-2,1,5-oxadiazoles - A novel classof heterocyclic monoamine oxidase inhibitors. Biochem. Pharmacol. 23: 1963-1968, 1974.

16. Ghosh PB and Everitt BJ: Furazanobenzofuroxan, furazanobenzothiadiazole,and their N-oxides. A new class of vasodilator drugs. J. Med. Chem. 17: 203-206, 1974.

17. Ingman AM, Ghosh P and Taylor TKF: Variation of collagenous and non-collagenous proteins of human knee joint menisci with age and degeneration.Gerontologia 20(4): 212-223, 1974.

18. Braund KG, Ghosh P, Taylor TKF and Larsen LH: Morphological studies ofthe canine intervertebral disc. The assignment of the beagle to theachondroplastic classification. Res. Vet. Sci. 19(2): 167-172, 1975.

19. Ghosh P, Ingman AM and Taylor TKF: Variations in collagen, non-collagenous proteins, and hexosamine in menisci derived from osteoarthriticand rheumatoid arthritic knee joints. J. Rheumatol. 2(1): 100-107, 1975.

20. Ghosh P, Stephens RW and Taylor TKF: Mechanism of cartilage and synovialfluid hyaluronate degradation by polysaccharidases. Ann. Rheum. Dis. Suppl.2: 73-74, 1975.

21. Ghosh P, Taylor TKF and Horsburgh BA: The composition and proteinmetabolism in the immature rabbit intervertebral disc. Cell Tissue Res. 163(2):223-238, 1975.

22. Ghosh P, Taylor TKF, Yarroll JM, Braund KG and Larsen LH: Genetic factorsin the maturation of the canine intervertebral disc. Res. Vet. Sci. 19: 304-311,1975.

23. Stephens RW, Ghosh P and Taylor TKF: The characterisation and function ofthe polysaccharidases of human synovial fluid in rheumatoid andosteoarthritis. Biochim. Biophys. Acta 399(1): 101-112, 1975.

24. Stephens RW, Ghosh P, Taylor TKF, Gale CA, Swann JC, Robinson RG andWebb J: The origins and relative distribution of polysaccharidases inrheumatoid and osteoarthritic fluids. J. Rheumatol. 2(4): 393-400, 1975.

25. Braund KG, Ghosh P, Taylor TKF and Larsen LH: The identification andquantitation of connective tissue hexosamines using a combination of gas-liquid chromatographic and colorimetric procedures. Anal. Biochem. 64(1):10-17, 1975.


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26. Ghosh P, Stephens RW and Taylor TKF: (Letter): The inhibition of synovialfluid polysaccharidases by gold sodium thiomalate. Med. J. Aust. 1: 317,1975.

27. Braund KG, Ghosh P, Taylor TKF and Larsen LH: The qualitative assessmentof glycosaminoglycans in the canine intervertebral disc using a criticalelectrolyte concentration staining technique. Res. Vet. Sci. 21: 314-317, 1976.

28. Ghosh P, Taylor TKF, Braund KG and Larsen LH: The collagenous and non-collagenous protein of the canine intervertebral disc and their variation withage, spinal level and breed. Gerontology 22(3): 124-134, 1976.

29. Ghosh P, Taylor TKF, Braund KG and Larsen LH: A comparative chemicaland histochemical study of the chondrodystrophoid andnonchondrodystrophoid canine intervertebral disc. Vet. Pathol. 13(6): 414-427, 1976.

30. McKenzie LS, Horsburgh BA, Ghosh P and Taylor TKF: Osteoarthrosis:Uncertain rationale for anti-inflammatory drug therapy. Lancet 1(7965): 908-909, 1976.

31. McKenzie LS, Horsburgh BA, Ghosh P and Taylor TKF: Effect of anti-inflammatory drugs on sulphated glycosaminoglycan synthesis in agedhuman articular cartilage. Ann. Rheum. Dis. 35(6): 487-497, 1976.

32. Shinmei M, Ghosh P and Taylor TKF: N6,02'-Dibutyryl adenosine 3',5'-monophosphate-stimulated release of proteoglycans from cultured immaturerabbit ear cartilage. Biochim. Biophys. Acta 437: 94-105, 1976.

33. Taylor TKF, Ghosh P, Braund KG, Sutherland JM and Sherwood AA: Theeffect of spinal fusion on intervertebral disc composition: An experimentalstudy. J. Surg. Res. 21(2): 91-104, 1976.

34. Braund KG, Taylor TKF, Ghosh P and Sherwood AA: Lateral spinaldecompression in the dog. J. Sm. Anim. Pract. 17(9): 583-592, 1976.

35. Stephens RW, Sutherland J, Ghosh P and Taylor TKF: Human serum andsynovial fluid hyaluronidase - Bovine testicular hyaluronidase is not a validsubstitute in drug evaluation studies. Biochem. Pharmacol. 25(13): 1507-1511, 1976.

36. Ghosh P, Taylor TKF and Braund KG: The variation of theglycosaminoglycans of the canine intervertebral disc with ageing. I.Chondrodystrophoid breed. Gerontology 23: 87-98, 1977.

37. Ghosh P, Taylor TKF and Braund KG: Variation of the glycosaminoglycans ofthe intervertebral disc with ageing. II. Non-chondrodystrophoid breed.Gerontology 23: 99-109, 1977.

38. McKenzie LS, Horsburgh BA, Ghosh P and Taylor TKF: Sulphatedglycosaminoglycan synthesis in normal and osteoarthrotic hip cartilage. Ann.Rheum. Dis. 36(4): 369-373, 1977.

39. McKenzie LS, Horsburgh BA, Ghosh P and Taylor TKF: Organ culture ofhuman articular cartilage: Studies on sulphated glycosaminoglycan synthesis.In Vitro 13(7): 423-428, 1977.


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40. Braund KG, Taylor TKF, Ghosh P and Sherwood AA: Spinal mobility in thedog. A study in chondrodystrophoid and non-chondrodystrophoid animals.Res. Vet. Sci. 22(1): 78-82, 1977.

41. Harris PA, Stephens RW, Ghosh P and Taylor TKF: Endo- andexoglycosidases in an experimental rat osteosarcoma. Aust. J. Exp. Biol.Med. Sci. 55(4): 363-370, 1977.

42. MacPhee DG, Robert GP, Ternai B, Ghosh P and Stephens R: Mutagenesisby 4-nitrobenzofurazans and furoxans. Chem. Biol. Interact. 19: 77-90, 1977.

43. Burkhardt D, Stephens RW, Ghosh P and Taylor TKF: Inhibition of synovialfluid lysosomal glycosidases by anti-arthritic gold preparations. AgentsActions 8(3): 251-257, 1978.

44. Bushell GR, Ghosh P, Taylor TKF, Sutherland JM and Braund KG: The effectof spinal fusion on the collagen and proteoglycans of the canine intervertebraldisc. J. Surg. Res. 25: 61-69, 1978.

45. Ghosh P, Taylor TKF, Bellenger C, Pettit G and Horsburgh B: Knee jointmeniscal regeneration and post-meniscectomy arthropathy - An experimentalstudy in the dog. Aust. N.Z. J. Med. 8: 34, 1978.


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46. Ghosh P: Lysosomal enzymes in joint disease. Aust. N.Z. J. Med. 8: 12-15,1978.

47. Stephens RW, Pemberton LI, Ghosh P and Taylor TKF: A radioassay forproteolytic cleavage of isolated cartilage proteoglycan. I. Separation principlesand variables. Anal. Biochem. 90(2): 726-736, 1978.

48. Dunn RI, Bolt AG, Ghosh P and Mrongovius RI: A novel activity cage for rats:Characterization of some phenylethylamine derivatives with central stimulantand depressant effects. Clin. Exp. Pharmacol. Physiol. 5: 627-633, 1978.

49. Ghosh P, Bolt AG and Mrongovius RI: 1,2-Diphenylethylamines as potentialnon stimulant anorectics. Arzneim.-Forsch./Drug Res. 28(9): 1561-1564,1978.

50. Bushell GR, Ghosh P and Taylor TKF: Collagen defect in idiopathic scoliosis.Lancet 2: 94-95, 1978.

51. Knight JA, Stephens RW, Bushell GR, Ghosh P and Taylor TKF: Neutralprotease inhibitors from human intervertebral disc and femoral head articularcartilage. Biochim. Biophys. Acta 584(2): 304-310, 1979.

52. Stephens RW, Ghosh P and Taylor TKF: The pathogenesis of osteoarthrosis.Med. Hypotheses 5(7): 809-816, 1979.

53. Mrongovius RI, Ghosh P and Bolt AG: Anorectic and motor activity effects ofsome 1-Benzylcycloalkylamines in the rat. Clin. Exp. Pharmacol. Physiol. 6:81-86, 1979.

54. Bushell GR, Ghosh P, Taylor TKF and Sutherland JM: The collagen of theintervertebral disc in adolescent idiopathic scoliosis. J. Bone Joint Surg. Br.61(4)B: 501-508, 1979.

55. Ghosh P, Bushell GR, Taylor TKF, Pearce RH and Grimmer BJ: Distributionof glycosaminoglycans across the normal and the scoliotic disc. Spine 5(4):310-317, 1980.

56. Pettit GR, Bellenger CR, Taylor TKF and Ghosh P: Die Behandlung vonMeniskusläsionen des Hundes. Kleintier Praxis, 25: 435-440, 1980.

57. Stephens RW, Walton EA, Ghosh P, Taylor TKF, Gramse M and HavemannK: A radioassay for proteolytic cleavage of isolated cartilage proteoglycan. 2.Inhibition of human leukocyte elastase and cathepsin G by anti-inflammatorydrugs. Arzneimittel-Forschung (Drug Res) 30(12): 2108-2112, 1980.

58. Taylor TKF, Ghosh P and Bushell GR: The contribution of the intervertebraldisk to the scoliotic deformity. Clin. Orthop. 156: 79-90, 1981.

59. Walton EA, Upfold LI, Stephens RW, Ghosh P and Taylor TKF: The role ofserine protease inhibitors in normal and osteoarthrotic human articularcartilage. Semin. Arthritis Rheum. 11 (Suppl. 1): 73-75, 1981.

60. Walton EA, Stephens RW, Ghosh P and Taylor TKF: Nonsteroidalantiinflammatory drugs (NSAIDs) and articular cartilage integrity. Semin.Arthritis Rheum. 11 (Suppl. 1): 147-149, 1981.


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61. Mrongovius RI, Ghosh P, Bolt AG and Ternai B: 1-(2-Thienyl)-2-phenylethylamines as potential non-stimulant anorectics. Arzneim.-Forsch. /Drug Res. 31(II) Nr.10: 1718-1720, 1981.

62. Taylor TKF and Ghosh P: Anti-inflammatory drugs in the management ofspondylosis. Br. Med. J. 283(6297): 951, 1981.

63. Ghosh P, Taylor TKF and Meachin AD: A double blind crossover trial ofindomethacin, flurbiprofen and placebo in the management of lumbarspondylosis. Curr. Ther. Res. 30(3): 318-326, 1981.

64. Andrews JL, Ghosh P, Ternai B and Whitehouse MW: Ammonium 4-chloro-7-sulfobenzofurazan: A new fluorigenic thiol-specific reagent. Arch. Biochem.Biophys. 214(1): 386-396, 1982.

65. Burkhardt D, Ghosh P, Ternai B and Whitehouse MW: Effects of 4-nitro and4-sulpho-7-substituted benzofurazans on nucleic acid and protein synthesis ofa malignant fibrosarcoma cell line in combination with mild hyperthermia.Chem. Biol. Interact. 42(2): 195-207, 1982.

66. Sinosich MJ, Davey MW, Ghosh P and Grudzinskas JG: Specific inhibition ofhuman granulocyte elastase by human pregnancy associated plasma proteinA. Biochem. Int. 5: 777-786, 1982.

67. Golding JC and Ghosh P: Drugs for osteoarthrosis. I: The effects of pentosanpolysulphate (SP54) on the degradation and loss of proteoglycans fromarticular cartilage in a model of osteoarthrosis induced in the rabbit knee jointby immobilization. Curr. Ther. Res. 33(2): 173-184, 1983.

68. Golding J and Ghosh P: Drugs for osteoarthrosis. II: The effects of aglycosaminoglycan polysulphate ester (Arteparon) on proteoglycanaggregation and loss from articular cartilage of immobilized rabbit knee joints.Curr. Ther Res. 34(1): 67-80, 1983.

69. Nakagawa T, Ghosh P and Nagai Y: Serine proteinase and serine proteinaseinhibitors of normal and degenerate knee joint menisci. Biomed. Res. 4(1):25-32, 1983.

70. Hanspal JS, Bushell GR and Ghosh P: Detection of protease inhibitors usingsubstrate-containing sodium dodecyl sulfate-polyacrylamide gelelectrophoresis. Anal. Biochem. 132(2): 288-293, 1983.

71. Ghosh P, Taylor TKF, Pettit GD, Horsburgh BA and Bellenger CR: Effects ofpostoperative immobilisation on the regrowth of the knee joint semilunarcartilage: An experimental study. J. Orthop. Res. 1: 153-164, 1983.

72. Andrews JL, Ghosh P, Lentini A and Ternai B: The interaction of pentosanpolysulphate (SP54) with human neutrophil elastase and connective tissuematrix components. Chem. Biol. Interact. 47(2): 157-173, 1983.

73. Ghosh P, Sutherland JM, Taylor TKF, Pettit GD and Bellenger CR: Theeffects of postoperative joint immobilization on articular cartilage degenerationfollowing meniscectomy. J. Surg. Res. 35(6): 461-473, 1983.

74. Ghosh P, Sutherland JM, Taylor TKF, Bellenger CR and Pettit GD: The effectof bilateral medial meniscectomy on articular cartilage of the hip joint. J.Rheumatol. 11(2): 197-201, 1984.


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75. Lesjak MS and Ghosh P: Polypeptide proteinase inhibitor from humanarticular cartilage. Biochim. Biophys. Acta 789(3): 266-277, 1984.

76. Frost L and Ghosh P: Microinjury to the synovial membrane may causedisaggregation of proteoglycans in rabbit knee joint articular cartilage. J.Orthop. Res. 2(3): 207-220, 1984.

77. Andrews JL, Sutherland JM and Ghosh P: The distribution and binding ofglycosaminoglycan polysulfate to intervertebral disc, knee joint articularcartilage and meniscus. Arzneimittelforschung (Drug Res.) 35(1): 144-148,1985.

78. Cole T-C, Burkhardt D, Ghosh P, Ryan M and Taylor T: Effects of spinalfusion on the proteoglycans of the canine intervertebral disc. J. Orthop. Res.3: 277-291, 1985.

79. Lentini A, Ternai B and Ghosh P: Synthetic inhibitors of human leukocyteelastase. Part 1. Sulphated polysaccharides. Biochem. Int. 10(2): 221-232,1985.

80. Cole T-C, Burkhardt D, Frost L and Ghosh P: The proteoglycans of the canineintervertebral disc. Biochem. Biophys. Acta 839(2): 127-138, 1985.

81. Smith MM and Ghosh P: The effects of some polysulphated polysaccharideson hyaluronate (HA) synthesis by human synovial fibroblasts. Agents Actions18 (Suppl.): 55-62, 1986.

82. Cole T-C, Ghosh P and Taylor TKF: Variation of the proteoglycans of thecanine intervertebral disc with ageing. Biochim. Biophys. Acta 880(2-3): 209-219, 1986.

83. Ghosh P, Andrews JL, Osborne RA and Lesjak MS: Variation with ageing anddegeneration of serine and cysteine proteinase inhibitors of human articularcartilage. Agents Actions 18 (Suppl.): 69-81, 1986.

84. Read R, Sutherland J and Ghosh P: The matrix components of epiphysealgrowth plate and articular cartilages from dogs treated with ammoniumtetrathiomolybdate, a copper antagonist. Aust. J. Exp. Biol. Med. Sci. 64(6):545-562, 1986.

85. Burkhardt D and Ghosh P: Laboratory evaluation of glycosaminoglycanpolysulphate ester for chondroprotective activity: A review. Curr. Ther. Res.40(6): 1034-1053, 1986.

86. Burkhardt D and Ghosh P: Laboratory evaluation of antiarthritic agents aspotential chondroprotective agents. Semin. Arthritis Rheum. 17(2) (Suppl. 1):3-34, 1987.

87. Hannan N, Ghosh P, Bellenger C and Taylor T: Systemic administration ofglycosaminoglycan polysulphate (Arteparon) provides partial protection ofarticular cartilage from damage produced by meniscectomy in the canine. J.Orthop. Res. 5(1): 47-59, 1987.

88. Melrose J, Ghosh P and Taylor TKF: Neutral proteinases of the humanintervertebral disc. Biochim. Biophys. Acta 923(3): 483-495, 1987.


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89. Ghosh P, Collier S and Andrews J: Synovial membrane-cartilage interactions- The role of serine proteinase inhibitors in interleukin-1 mediated degradationof articular damage. J. Rheumatol. 14 (Suppl. 14): 122-124, 1987.

90. Cole T-C, Ghosh P, Hannan NJ, Taylor TKF and Bellenger CR: The responseof the canine intervertebral disc to immobilization produced by spinalarthrodesis is dependent on constitutional factors. J. Orthop. Res. 5(3): 337-347, 1987.

91. Cullis-Hill D and Ghosh P: The role of hyaluronic acid in joint stability - Ahypothesis for hip dysplasia and allied disorders. Med. Hypotheses 23(2):171-185, 1987.

92. Smith MM and Ghosh P: The synthesis of hyaluronic acid by human synovialfibroblasts is influenced by the nature of the hyaluronate in the extracellularenvironment. Rheumatol. Int. 7(3): 113-122, 1987.

93. Cook L, Ternai B and Ghosh P: Inhibition of human sputum elastase bysubstituted 2-pyrones. J. Med. Chem. 30: 1017-1023, 1987.

94. Melrose J and Ghosh P: Low molecular weight serine proteinase inhibitors ofthe human intervertebral disc. Biochem. Int. 15(1): 117-125, 1987.

95. Lentini A, Ternai B and Ghosh P: Synthetic inhibitors of human granulocyteelastase. Part 4. Inhibition of human granulocyte elastase and cathepsin G bynon-steroidal anti-inflammatory drugs (NSAIDs). Biochem. Int. 15(6): 1069-1078, 1987.

96. Cole T-C, Melrose J and Ghosh P: Cysteine proteinase inhibitors of theintervertebral disc. Biochim. Biophys. Acta 952(2): 201-207, 1988.

97. Hutadilok N, Ghosh P and Brooks P: Binding of haptoglobin, inter-a-trypsininhibitor and a1-proteinase inhibitor to synovial fluid hyaluronate and theinfluence of these proteins on its degradation by oxygen derived free radicals.Ann. Rheumatic. Dis. 47(5): 377-385, 1988.

98. Lentini A, Ternai B and Ghosh P: Interaction of heparin and SP54 with gelatin.Int. J. Biol. Macromol. 10: 113-120, 1988.

99. Melrose J and Ghosh P: The quantitative discrimination of corneal type I, butnot skeletal type II keratan sulphate in glycosaminoglycan mixtures by using acombination of dimethylmethylene blue and endo-b-D-galactosidasedigestion. Anal. Biochem. 170(2): 293-300, 1988.

100. Collier S and Ghosh P: The role of plasminogen in interleukin-1 mediatedcartilage degradation. J. Rheumatol. 15(7): 1129-1137, 1988.

101. Hutadilok N, Smith MM, Cullis-Hill D, Brooks PM and Ghosh P: Pentosanpolysulphate stimulates hyaluronate and DNA synthesis in synovial fibroblastsand partially reduces the suppressive effect of hydrocortisone on fibroblastmetabolism. Curr. Ther. Res. 44(5): 845-860, 1988.

102. Cole T-C, Melrose J and Ghosh P: Isolation and characterisation of a neutralproteinase from the canine intervertebral disc. Biochim. Biophys. Acta 990(3):254-262, 1989.


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103. Ghosh P: Therapeutic modulation of cartilage catabolism by nonsteroidalantiinflammatory drugs (NSAIDs) in arthritis. Semin. Arthritis Rheum. 18(Suppl. 1): 2-6, 1989.

104. Francis DJ, Forrest MJ, Brooks PM and Ghosh P: Retardation of articularcartilage degradation by glycosaminoglycan polysulfate, pentosan polysulfate,and DH-40J in the rat air pouch model. Arthritis Rheum. 32(5): 608-616, 1989.

105. Collier S and Ghosh P: Evaluation of the effects of antiarthritic drugs on thesecretion of proteoglycans by lapine chondrocytes using a novel assayprocedure. Ann. Rheum. Dis. 48(5): 372-381, 1989.

106. Kongtawelert P and Ghosh P: An enzyme-linked immunosorbent-inhibitionassay for quantitation of hyaluronan (hyaluronic acid) in biological fluids. Anal.Biochem. 178(2): 367-372, 1989.

107. Kongtawelert P, Francis DJ, Brooks PM and Ghosh P: Application of anenzyme-linked immunosorbent inhibition assay to quantitate the release of KSpeptides into fluids of rat subcutaneous air-pouch model and the effects ofchondroprotective drugs on the release process. Rheumatol. Int. 9(2):77-83,1989.

108. Melrose J, Ghosh P and Taylor TKF: Lysozyme, a major low molecular weightcationic protein of the intervertebral disc, which increases with ageing anddegeneration. Gerontology 35(4): 173-180, 1989.

109. Kongtawelert P, Brooks PM and Ghosh P: Pentosan polysulfate(Cartrophen®) prevents the hydrocortisone induced loss of hyaluronic acidand proteoglycan from cartilage of rabbit joints as well as normalizes thekeratan sulfate levels in their serum. J. Rheumatol. 16(11): 1454-1459, 1989.

110. Ghosh P: The role of serine proteinases and serine proteinase inhibitors inthe pathobiology of connective Tissues. J. Jpn. Orthop. 63(5): 643-652, 1989.

111. Ghosh P: Articular cartilage: What it is, Why it fails in osteoarthritis, and Whatcan be done about it. Arthritis Care Res. 1(4): 211-221, 1989.

112. Kongtawelert P and Ghosh P: A monoclonal antibody that recognizes 2,3-,2,6-, and 4,6-disulphate ester ring substitution in pyranose-containingpolysaccharides. Its production, characterization and application for thequantitation of pentosan polysulphate, dextran sulphate, glycosaminoglycanpolysulphate and chondroitin sulphate E. J. Immunol. Methods 126(1): 39-49,1990.

113. Ghosh P, Wells C, Smith M and Hutadilok N: Chondroprotection, myth orreality: An experimental approach. Semin. Arthritis Rheum. 19(14) (Suppl. 1):3-9, 1990.

114. Ghosh P, Sutherland J, Bellenger C, Read R and Darvodelsky A: Theinfluence of weight-bearing exercise on articular cartilage of meniscectomizedjoints. An experimental study in sheep. Clin. Orthop. 252: 101-113, 1990.

115. Kongtawelert P and Ghosh P: A method for the quantitation of hyaluronan(hyaluronic acid) in biological fluids using a labeled avidin-biotin technique.Anal. Biochem. 185(2): 313-318, 1990.


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116. Andrews JL and Ghosh P: Low molecular weight serine proteinase inhibitorsof human articular cartilage. Isolation, characterisation and biosynthesis.Arthritis Rheum. 33(9): 1384-1393, 1990.

117. Kongtawelert P and Ghosh P: A new sandwich-ELISA method for thedetermination of keratan sulphate peptides in biological fluids employing amonoclonal antibody and labelled avidin biotin technique. Clin. Chim. Acta.195(1-2): 17-26, 1990.

118. Melrose J, Gurr KR, Cole T-C, Darvodelsky A, Ghosh P and Taylor TKF: Theinfluence of scoliosis and ageing on proteoglycan heterogeneity in the humanintervertebral disc. J. Orthop. Res. 9(1): 68-77, 1991.

119. Ghosh P, Burkhardt D, Read R and Bellenger C: Recent advances in modelsfor evaluating chondroprotective drugs. J. Rheumatol. 18(Suppl. 27): 143-146,1991.

120. Hutadilok N, Smith MM and Ghosh P: Effects of hydrogen peroxide on themetabolism of human rheumatoid and osteoarthritic synovial fibroblasts invitro. Ann. Rheum. Dis. 50(4): 219-226, 1991.

121. Collier S and Ghosh P: Comparison of the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on proteoglycan synthesis by articular cartilageexplants and chondrocyte monolayer cultures. Biochem. Pharmacol. 41(9):1375-1384, 1991.

122. Meyer-Carrive I and Ghosh P: Effects of tiaprofenic acid (Surgam) oncartilage proteoglycans in the rabbit joint immobilisation model. Ann. Rheum.Dis. 51(4): 448-455, 1992.

123. Ghosh P, Melrose J, Cole T-C and Taylor T: A comparison of the highbuoyant density proteoglycans isolated from the intervertebral discs ofchondrodystrophoid and non-chondrodystrophoid dogs. Matrix 12(2): 148-155, 1992.

124. Andrews JL, Melrose J and Ghosh P: A comparative study of the low-molecular serine proteinase inhibitors of human connective tissues. Biol.Chem. Hoppe Seyler 373(3): 111-118, 1992.

125. Melrose J, Ghosh P, Taylor TKF, Hall A, Osti OL, Vernon-Roberts B andFraser RD: A longitudinal study of the matrix changes induced in theintervertebral disc by surgical damage to the annulus fibrosus. J. Orthop. Res.10(5): 665-676, 1992.

126. Melrose J and Ghosh P: Development of an avidin-biotin competitiveinhibition assay and validation of its use for the quantitation of humanintervertebral disc serine proteinase inhibitory proteins. Anal. Biochem.204(2): 372-382, 1992.

127. Nethery A, Giles I, Jenkins K, Jackson C, Brooks P, Burkhardt D, Ghosh P,Whitelock J, O'Grady RL, Welgus HG and Schrieber L: The chondroprotectivedrugs, Arteparon and sodium pentosan polysulphate, increase collagenaseactivity and inhibit stromelysin activity in vitro. Biochem. Pharmacol. 44(8):1549-1553, 1992.

128. Melrose J, Ghosh P, Taylor TKF and Andrews JL: The serine proteinaseinhibitory proteins of the human intervertebral disc: Their isolation,


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characterization and variation with ageing and degeneration. Matrix 12(6):456-470, 1992.

129. Ghosh P: Non-steroidal anti-inflammatory drugs and chondroprotection: Areview of the evidence. Drugs 46(5): 834-846, 1993.

130. Hope N, Ghosh P, Taylor TKF, Sun D and Read R: Effects of intraarticularhyaluronan on matrix changes induced in the lateral meniscus by total medialmeniscectomy and exercise. Semin. Arthritis Rheum. 22(6) (Suppl. 1): 43-51,1993.

131. Ghosh P, Read R, Armstrong S, Wilson D, Marshall R and McNair P: Theeffects of intra-articular administration of hyaluronan in a model of earlyosteoarthritis in sheep. I. - Gait analysis, radiological and morphologicalstudies. Semin. Arthritis Rheum. 22(6) (Suppl. 1): 18-30, 1993.

132. Ghosh P, Read R, Numata Y, Smith S, Armstrong S and Wilson D: Theeffects of intra-articular administration of hyaluronan in a model of earlyosteoarthritis in sheep. II. Cartilage composition and proteoglycanmetabolism. Semin. Arthritis Rheum. 22(6) (Suppl. 1): 31-42, 1993.

133. Armstrong SJ, Read RA, Ghosh P and Wilson DM: Moderate exerciseexacerbates the osteoarthritic lesions produced in cartilage by meniscectomy:A morphological study. Osteoarthritis Cartilage 1: 89-96, 1993.

134. Ghosh P: Osteoarthritis and hyaluronan: Palliative or disease modifyingtreatment? Semin. Arthritis Rheum. 22(6) (Suppl. 1): 1-3, 1993.

135. Melrose J, Ghosh P: Determination of the average molecular size ofglycosaminoglycans by fast protein liquid chromatography. J Chromatogr.637: 91-95, 1993.

136. Ghosh P and Smith M: The role of cartilage-derived antigens, pro-coagulantactivity and fibrinolysis in the pathogenesis of osteoarthritis. Med. Hypotheses41(2): 190-194, 1993.

137. Francis DJ, Hutadilok N, Kongtawelert P and Ghosh P: Pentosanpolysulphate and glycosaminoglycan polysulphate stimulates the synthesis ofhyaluronan in vivo. Rheumatol. Int. 13(2): 61-64, 1993.

138. Meyer-Carrive I, Graham GG and Ghosh P: Pharmacokinetics of tiaprofenicacid in normal rabbits and rabbits subjected to joint immobilization. AgentsActions 39: 59-68, 1993.

139. Jacoby AS, Melrose J, Robinson BG, Hyland VJ and Ghosh P: Secretoryleukocyte proteinase inhibitor is produced by human articular cartilagechondrocytes and intervertebral disc fibrochondrocytes. Eur. J. Biochem.218(3): 951-957, 1993.

140. Bansal MK, Smith MM, Numata Y and Ghosh P: The effects of calciumpentosan polysulphate on inflammatory mediators in the rat air-pouch modelof inflammation. Curr. Ther. Res. 54(6): 714-730, 1993.

141. Ghosh P, Wells C, Numata Y, Read R and Armstrong S: The effects of orallyadministered tiaprofenic acid on the biosynthesis of proteoglycans in ex vivocartilage cultures from joints of animals with early osteoarthritis. Curr. Ther.Res. 54(6): 703-713, 1993.


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142. Smith MM, Ghosh P, Numata Y and Bansal MK: The effects of orallyadministered calcium pentosan polysulfate on inflammation and cartilagedegradation produced in rabbit joints by intraarticular injection of ahyaluronate-polylysine complex. Arthritis Rheum. 37(1): 125-136, 1994.

143. Ghosh P: The role of hyaluronic acid (hyaluronan) in health and disease:Interactions with cells, cartilage and components of synovial fluid. Clin. Exp.Rheumatol. 12(1): 75-82, 1994.

144. Melrose J, Ghosh P and Taylor TKF: Proteoglycan heterogeneity in thenormal adult ovine intervertebral disc. Matrix Biol. 14(1): 61-75, 1994.

145. Melrose J, Ghosh P and Jacoby A: A solid phase enzyme linkedimmunofiltration assay for secretory leucocyte proteinase inhibitor. Clin.Chem. Acta 225: 17-28, 1994.

146. Armstrong S, Read R and Ghosh P: The effects of intraarticular hyaluronanon cartilage and subchondral bone changes in an ovine model of earlyosteoarthritis. J. Rheumatol. 21(4): 680-688, 1994.

147. Ghosh P, Hutadilok N and Lentini A: Nuclear magnetic resonance studies ofhyaluronan (HA): Evidence of competitive inhibition of interchain associationsby phospholipids which may result in decreased anti-inflammatory andcartilage protecting properties of HA. Heterocycles 38: 1757-1774, 1994.

148. Theiler R, Ghosh P and Brooks P: Clinical assessment methods inosteoarthritis and clinical trials with chondromodulating agents. OsteoarthritisCartilage 2: 1-23, 1994.

149. Melrose J, Ghosh P, Taylor TKF and McAuley L: A comparative study of thecomposition of discs and of proteoglycans from different spinal levels ofsheep. Vet. Comp. Orthop. Traumatol. 7: 70-76, 1994.

150. Melrose J, Rodgers K and Ghosh P: The preparation and use of biotinylatedtrypsin and its use in Western blotting for the detection of trypsin inhibitoryproteins. Anal. Biochem. 222: 34-43, 1994.

151. Ghosh P, Hutadilok N, Adam N and Lentini A: Interactions of hyaluronan(hyaluronic acid) with phospholipids as determined by gel permeationchromatography, multi-angle laser-light scattering photometry and 1H-NMRspectroscopy. Int. J. Biol. Macromol. 16(5): 237-244, 1994.

152. Ghosh P, Holbert C, Read R and Armstrong S: Hyaluronic acid (hyaluronan)in experimental osteoarthritis. J. Rheumatol. 22 (Suppl. 43): 155-157, 1995.

153. Melrose J, Hall A, Macpherson C, Bellenger CR and Ghosh P: Evaluation ofdigestive proteinases from the Antarctic Krill Euphasia Superba, as potentialchemonucleolytic agents. In vitro and in vivo studies. Arch. Orthop. TraumaSurg. 114(3): 145-152, 1995.

154. Rodgers KJ, Melrose J and Ghosh P: Biotin-labeled potato chymotrypsininhibitor-1: A useful probe for the detection and quantitation of chymotrypsin-like serine proteinases on western blots and its application in the detection ofa serine proteinase synthesised by articular chondrocytes. Anal. Biochem.227: 129-134, 1995.


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155. Collier S and Ghosh P: Effects of transforming growth factor beta onproteoglycan synthesis by cell and explant cultures derived from the kneejoint meniscus. Osteoarthritis Cartilage 3(2): 127-138, 1995.

156. Melrose J, Ghosh P and Patel M: Biotinylated aprotinin: A versatile probe forthe detection of serine proteinases on Western blots. Int. J. Biochem. CellBiol. 27(9): 891-904, 1995.

157. Melrose J, Numata Y and Ghosh P: Biotinylated hyaluronan: A versatile andhighly sensitive probe capable of detecting nanogram levels of hyaluronbinding proteins (hyaladherins) on electroblots by a novel affinity detectionprocedure. Electrophoresis 17: 205-212, 1996.

158. Rodgers KJ, Melrose J and Ghosh P: Biotinylated trypsin and its applicationas a sensitive, versatile probe for the detection and characterisation of anovine chondrocyte serine proteinase inhibitor using Western blotting.Electrophoresis 17: 213-218, 1996.

159. Patel MI, Ghosh P, Melrose J and Appleberg M: Smooth muscle cell migrationand proliferation is enhanced in abdominal aortic aneurysms. Aust. N.Z. J.Surg. 66(5): 305-308, 1996.

160. Collier S, Hope N and Ghosh P: Healing of circular defects in the rabbitmedial meniscus can occur spontaneously and not improved by intra-articularhyaluronic acid. Vet. Comp. Orthop. Traumatol. 9(2): 60-65, 1996.

161. Patel MI, Melrose J, Ghosh P and Appleberg M: Increased synthesis of matrixmetalloproteinases by aortic smooth muscle cells is implicated in theetiopathogenesis of abdominal aortic aneurysms. J. Vasc. Surg. 24(1): 82-92,1996.

162. Melrose J, Taylor TKF, Ghosh P, Holbert C, Macpherson C and BellengerCR: Intervertebral disc reconstitution after chemonucleolysis withchymopapain is dependent on dosage. An experimental study in beagle dogs.Spine 21(1): 9-17, 1996.

163. Little C, Ghosh P and Bellenger CR: Topographic variation in biglycan anddecorin synthesis by articular cartilage in the early stages of osteoarthritis: Anexperimental study in sheep. J. Orthop. Res. 14(3): 433-444, 1996.

164. Ghosh P and Hutadilok N: Interactions of pentosan polysulfate with cartilagematrix proteins and synovial fibroblasts derived from patients withosteoarthritis. Osteoarthritis Cartilage 4(1): 43-53, 1996.

165. Melrose J, Taylor TKF and Ghosh P: Variation in intervertebral disc serineproteinase inhibitory proteins with ageing in a chondrodystrophoid (beagle)and non-chondrodystrophoid (greyhound) canine breed. Gerontology 42: 322-329, 1996.

166. Rodgers K, Melrose J and Ghosh P: Purification and characterisation of 6 and58 kDa forms of the endogenous serine proteinase inhibitory proteins of ovinearticular cartilage. Biol. Chem. Hoppe Seyler 377: 837-845, 1996.

167. Smith MM, Little CB, Rodgers K and Ghosh P: Animal models used toevaluate anti-osteoarthritis drugs. Pathol. Biol. [Paris] 45(4): 313-320, 1997.


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168. Melrose J, Ghosh P, Taylor TKF, Latham J and Moore R: Topographicalvariation in the catabolism of aggrecan in an ovine annular lesion model ofexperimental disc degeneration. J. Spinal Disord. 10(1): 55-67, 1997.

169. Little C, Ghosh P and Rose R: The effect of strenuous versus moderateexercise on the metabolism of proteoglycans in different weight-bearingregions of the equine third carpal bone. Osteoarthritis Cartilage 5(3): 161-172,1997.

170. Little C and Ghosh P: Variation in proteoglycan metabolism by articularchondrocytes in different joint regions is determined by post-natal mechanicalloading. Osteoarthritis Cartilage 5(1): 49-62, 1997.

171. Anderson JM, Edelman J and Ghosh P: The effects of pentosan polysulphateon peripheral blood leukocyte populations and monocyte procoagulant activityin patients with osteoarthritis. Curr. Ther. Res. 58: 93-107, 1997.

172. Melrose J, Taylor TKF and Ghosh P: The serine proteinase inhibitory proteinsof the chondrodystrophoid (beagle) and non-chondrodystrophoid (greyhound)canine intervertebral disc. Electrophoresis 18(7): 1059-1063, 1997.

173. Little C, Smith S, Ghosh P and Bellenger CR: Histomorphological andimmunohistochemical evaluation of the joint changes in a model ofosteoarthritis induced by lateral meniscectomy in sheep. J. Rheumatol.24(11): 2199-2209, 1997.

174. Pasquali-Ronchetti I, Quaglino D, Mori G, Bacchelli B and Ghosh P:Hyaluronan - Phospholipid interactions. J. Struct. Biol. 120(1): 1-10, 1997.

175. Melrose J, Ghosh P, Taylor TKF, Vernon-Roberts B, Latham J and Moore R:Elevated synthesis of biglycan and decorin in an ovine annular lesion modelof experimental disc degeneration. Eur. Spine J. 6(6): 376-384, 1997.

176. Melrose J, Little CB and Ghosh P: Detection of aggregatable proteoglycanpopulations by affinity blotting using biotinylated hyaluronan. Anal. Biochem.256(2): 149-157, 1998.

177. Melrose J, Whitelock J, Xu Q and Ghosh P: Pathogenesis of abdominal aorticaneurysms: Possible role of differential production of proteoglycans bysmooth muscle cells. J. Vasc. Surg. 28(4): 676-686, 1998.

178. Ghosh P, Xu A, Hwa S-Y, Burkhardt D and Little C: Evaluation of theprotective effects of diacerhein on cartilage and subchondral bone in an ovinemodel of osteoarthritis. Revue du Praticien 48(Suppl. 17): S24-30, 1998.

179. Simpson DS, Bellenger CR, Ghosh P, Numata Y and Little C: The effect oftotal meniscectomy versus caudal pole hemimeniscectomy on the stifle jointof the sheep. V.C.O.T. 12(2): 56-63, 1999.

180. Francis DJ, Andrews BA, Brooks PM and Ghosh P: Chondroprotective effectof extracts of normal human articular cartilage on matrix degradation in ratsubcutaneous air-pouch model of inflammation. APLAR J. Rheumatol. 3: 298-305, 1999.

181. Ghosh P: Evaluation of disease progression during nonsteroidalantiinflammatory drug treatment - Experimental models. International


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Federation of Societies on Skeletal Diseases. New York, USA, 23-24 May1998. Osteoarthritis Cartilage 7(3): 340-342, 1999.

182. Appleyard RC, Ghosh P and Swain MV: Biomechanical, histological andimmunohistological studies of patellar cartilage in an ovine model ofosteoarthritis induced by lateral meniscectomy. Osteoarthritis Cartilage 7(3):281-294, 1999.

183. Smith MM, Numata Y and Ghosh P: Effects of calcium pentosan polysulfateon joint inflammation and pouch fluid levels of leukocytes, nitric oxide andinterleukin-6 in a rat model of arthritis. Current Therapeutic Research 60(11):561-576, 1999.

184. Micklethwaite L, Ghosh P, Little CB, Hodgson DR and Rose RJ: Proteoglycancomposition and biosynthesis in superficial and deep digital flexor tendons ofstandardbred horses. V.C.O.T. 12: 166-1999.

185. Takizawa M, Ohuchi E, Yamanaka H, Nakamura H, Ikeda E, Ghosh P andOkada Y: Production of tissue inhibitor of metalloproteinases 3 is selectivelyenhanced by calcium pentosan polysulfate in human rheumatoid synovialfibroblasts. Arthritis Rheum. 43(4): 812-820, 2000.

186. Melrose J, Smith S and Ghosh P: Differential expression of proteoglycanepitopes by ovine intervertebral disc cells. J. Anat. 197(pt. 2): 189-198, 2000.

187. Melrose J, Smith S, Rodgers K, Little C, Burkhardt D and Ghosh P:Immunolocalisation of BPTI-like serine proteinase inhibitory proteins in mastcells, chondrocytes and intervertebral disc fibrochondrocytes of ovine andbovine connective tissues. An immunohistochemical and biochemical study.Histochem. Cell Biol. 114(2): 137-146, 2000.

188. Taylor TKF, Melrose J, Burkhardt D, Ghosh P, Claes LE, Kettler A and WilkeH-J: Spinal biomechanics and aging are major determinants of theproteoglycan metabolism of intervertebral disc cells. Spine 25(23): 3014-3020, 2000.

189. Cake MA, Read RR and Ghosh P: Modification of articular cartilage andsubchondral bone pathology in an ovine meniscectomy model of osteoarthritisby avocado and soya unsaponifiables (ASU). Osteoarthritis Cartilage 8(6):404-411, 2000.

190. Edelman J, Hanrahan P and Ghosh P: Deer antler cartilage in the treatmentof arthritis: Results of a 6 month placebo-controlled double-blind study withCervusen® in 54 patients with osteoarthritis. APLAR J. Rheumatol. 4(2): 95-100, 2000.

191. Melrose J, Ghosh P and Taylor TKF: A comparative analysis of the differentialspatial and temporal distributions of the large (aggrecan, versican) and small(decorin, biglycan, fibromodulin) proteoglycans of the intervertebral disc. J.Anat. 198: 3-15, 2001.

192. Melrose J, Smith S, Ghosh P and Taylor TKF: Differential expression ofproteoglycan epitopes and growth characteristics of intervertebral disc cellsgrown in alginate bead culture. Cells Tissues Organs 168(3): 137-146, 2001.


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193. Degenhardt M, Ghosh P and Watzig H: Studies on the structural variations ofpentosan polysulphate sodium (NaPPS) from different sources by capillaryelectrophoresis. Arch. Pharm. Pharm. Med. Chem. 334: 27-29, 2001.

194. Hwa S-Y, Burkhardt D, Little C and Ghosh P: The effects of orallyadministered Diacerhein on cartilage and subchondral bone in an ovine modelof osteoarthritis. J. Rheumatol. 28(4): 825-834, 2001.

195. Burkhardt D, Hwa S-Y and Ghosh P: A novel microassay for the quantitationof the sulfated glycosaminoglycan content of histological sections: Itsapplication to determine the effects of Diacerhein on cartilage in an ovinemodel of osteoarthritis. Osteoarthritis Cartilage 9: 238-247, 2001.

196. Pattison ST, Melrose J, Ghosh P and Taylor TKF: Regulation of galatinase-A(MMP-2) production by ovine intervertebral nucleus pulposus cells grown inalginate bead culture by transforming growth factor-b1 and insulin like growthfactor-I. Cell Biol. Int. 25(7): 679-689, 2001.

197. Adam N and Ghosh P: Hyaluronan molecular weight and polydispersity insome commercial intra-articular injectable preparations and in synovial fluid.Inflamm. Res. 50(6): 294-299, 2001.

198. Melrose J, Shen B and Ghosh P: Affinity and Western blotting revealhomologies between ovine intervertebral disc serine proteinase inhibitoryproteins and bovine pancreatic trypsin inhibitor. Proteomics 1(12): 1529-1533,2001.

199. Fuller CJ, Ghosh P and Barr AR: Plasma and synovial fluid concentrations ofcalcium pentosan polysulphate achieved in the horse following intramuscularinjection. Equine Vet. J. 34(1): 61-64, 2002.

200. Melrose J, Smith S and Ghosh P: Synthesis of a kunitz-type serine proteinaseinhibitory protein that shares homology with bovine pancreatic trypsin inhibitorby ovine intervertebral disc cells in serum-free alginate bead culture. J. SpinalDisord. Tech. 15(2): 164-171, 2002.

201. Ghosh P and Smith M: Osteoarthritis, genetic and molecular mechanisms.Biogerontology 3(1-2): 85-88, 2002.

202. Melrose J, Roberts S, Smith S, Menage J and Ghosh P: Increased nerve andblood-vessel ingrowth associated with proteoglycan depletion in an ovineannular lesion model of experimental disc degeneration. (ISSLS SpecialSocietal Issue) Spine 27(12): 1278-1285, 2002.

203. Melrose J, Smith S, Little CB, Kitson J, Hwa S-Y and Ghosh P: Spatial andtemporal localization of transforming growth factor-β, fibroblast growth factor-2, and osteonectin, and identification of cells expressing α-smooth muscleactin in the injured annulus fibrosus. Implications for extracellular matrixrepair. Spine 27(16): 1756-1764, 2002.

204. Shen B, Melrose J and Ghosh P: Induction of matrix metalloproteinase-2 and-3 activity in nucleus pulposus cells grown in three-dimensional agarose gelculture by interleukin-1β: A potential pathway of disc degeneration. Eur. SpineJ. 12: 66-75, 2003.


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205. Shen B, Shimmon S, Smith MM and Ghosh P: Biosensor analysis of themolecular interactions of pentosan polysulfate and of sulfatedglycosaminoglycans with immobilized elastase, hyaluronidase and lysozymeusing surface plasmon resonance (SPR) technology. J. Pharm. Biomed. Anal.31: 83-93, 2003.

206. Appleyard RC, Burkhardt D, Ghosh P, Read R, Cake M, Swain MV andMurrell GAC: Topographical analysis of the structural, biochemical anddynamic biomechanical properties of cartilage in an ovine model ofosteoarthritis. Osteoarthritis Cartilage 11: 65-77, 2003.

207. Ghosh P: Osteoarthritis – 2002 and Beyond. APLAR J. Rheumatol. 6(1): 79-84. 2003.

208. Parker D, Hwa S-Y, Sambrook P and Ghosh P: Estrogen replacementtherapy mitigates the loss of joint cartilage proteoglycans and bone mineraldensity induced by ovariectomy and osteoarthritis. APLAR J. Rheumatol. 6(2):116-127, 2003.

209. Melrose J, Smith S, Ghosh P and Whitelock J: Perlecan, the multidomainheparan sulfate proteoglycan of basement membranes, is also a prominentcomponent of the cartilaginous primordia in the developing human fetal spine.J. Histochem. Cytochem. 51(10): 1331-1341, 2003.

210. Cake MA, Read RA, Smith SM and Ghosh P: Topical administration of thenitric oxide donor glyceryl trinitrate modifies the structural and biomechanicalproperties of ovine articular cartilage. Osteoarthritis Cartilage 11:872-878,2003.

211. Hannon RL, Smith JG, Cullis-Hill D, Ghosh P and Cawdery MJ: Safety ofCartrophen-Vet® in the dog: A review of adverse reaction reports in the UK. JSmall Animal Practice. 44: 202-208, 2003.

212. Melrose J, Smith S, Ghosh P and Taylor TKF: Comparison of the morphologyand growth characteristics of intervertebral disc cells, synovial fibroblasts andarticular chondrocytes in monolayer and alginate bead cultures. Eur. Spine J.(in press).

213. Melrose J, Smith S and Ghosh P: Assessment of the cellular heterogeneity ofthe ovine intervertebral disc: Comparison with synovial fibroblasts andarticular chondrocytes. Eur. Spine J. 12: 57 – 65. 2003.

214. Melrose J, Smith S and Ghosh P. Histological and immunohistological studieson cartilage. Methods Mol Med. 101: 39 –63, 2004.

215. Oakley SP, Lassere MN, Portek I, Szomor Z, Ghosh P, Kirkham BW, MurrellGAC, Smith S, Wulf S and Appleyard RC: Biomechanical, histologic andmacroscopic assessment of articular cartilage in a sheep model ofosteoarthritis. Osteoarthritis Cartilage. 12:667 – 79, 2004.

216. Cake MA, Read RA, Appleyard RC, Hwa SY and Ghosh P. The nitric oxidedonor glyceryl trinitrite increases subchondral bone sclerosis and cartilagedegeneration following ovine meniscectomy. Osteoarthritis and Cartilage. 12:974 – 81, 2004.

217. Oakley SP, Portek I, Szomor Z, Appleyard RC, Ghosh P, Kirkham BW,Murrell GA, Lassere MN. Arthroscopy – a potential “gold standard” for the


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diagnosis of the chondropathy of early osteoarthritis. Osteoarthritis andCartilage. 13: 368 – 78, 2005.

218. Young AA, Smith MM, Cake MA, Ghosh P, Read RA, Melrose J, SonnabendDH and Little CB. Regional assessment of articular cartilage gene expressionand small proteoglycan metabolism in an animal model of osteoarthritis.Arthritis Research Ther. 7: R852 – 61, 2005.

219. Ghosh P, Shimmon S, Whitehouse, The immunological basis for inflammationand cartilage destruction in osteoarthritis. New opportunities for therapeuticintervention. Reumatismo, 57: 110-112. 2005.

220. Ghosh P, Edelman J, March L and Smith M. Effects of pentosan polysulfate inosteoarthritis of the knee: a randomized, double blind, placebo-controlled pilotstudy. Current Ther Research. 66: 552 – 571, 2005.

221. Oakley SP, Portek I, Szomor Z, Appleyard RC, Ghosh P, Kirkham BW,Murrell GA, Lassere MN. Arthroscopic estimation of the extent ofchondropathy. Osteoarthritis and Cartilage. Dec 21, 2006.

222. Ghosh P, Shimmon S and Whitehouse M. Arthritic disease suppression andcartilage protection with glycosaminoglycan peptide complexes (Peptacans)derived from the cartilage extracellular matrix. Inflammopharmacology. 14:161- 68, 2006.


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(vi) Major Reviews

1. Burkhardt D and Ghosh P: Hyperthermia and cancer. Aust. N.Z. J. Surg.47(5): 571-576, 1977.

2. Bushell GR, Ghosh P, Taylor TKF and Akeson WH: Proteoglycan chemistryof the intervertebral disks. Clin. Orthop. 129: 115-123, 1977.

3. Ghosh P, Bushell GR, Taylor TKF and Akeson WH: Collagens, elastin andnoncollagenous protein of the intervertebral disk. Clin. Orthop. 129: 124-132,1977.

4. Akeson WH, Woo SL-Y, Taylor TKF, Ghosh P and Bushell GR: Biomechanicsand biochemistry of the intervertebral disks: The need for correlation studies.Clin. Orthop. 129: 133-140, 1977.

5. Ghosh P and Taylor TKF: The knee joint meniscus. A fibrocartilage of somedistinction. Clin. Orthop. 224: 52-63, 1987.

6. Ghosh P: Du Rolle von mechanischen und genetischen Faktoren in derDegeneration der Band scheibe. Manuelle Medizin 29: 21-25, 1991.

7. Ghosh P: Osteoarthritis: Aetiopathogenesis and management. Mod. Med., 68-80, 1991.

8. Little C and Ghosh P: Structural and functional changes in articular cartilagewith aging, mechanical loading and osteoarthritis. Aust. Musculoskeletal Med.1: 14-25, 1996.

9. Smith MM and Ghosh P: Osteoarthritis: Current status and future directions.APLAR J. Rheumatol. 2(1): 27-53, 1998.

10. Ghosh P: The pathobiology of osteoarthritis and the rationale for the use ofpentosan polysulfate for its treatment. Semin. Arthritis Rheum. 28(4): 211-267, 1999.

11. Ghosh P and Guidolin D: Mechanism of action of intra-articular hyaluronan inosteoarthritis: Are its effects molecular weight dependent? Semin. ArthritisRheum. 32(1): 10-37, 2002.

(vii) Other Articles

1. Taylor TKF and Ghosh P: The disc factor in back strain. Special publication ofRoyal Australasian College of Surgeons. Seminars on Occupational Injuries,1973.

2. Gosh P (sic) and Taylor TKF: The reactions of connective tissue to physicalstress. Chapter 9 "Strains at Work" Special publication of Royal AustralasianCollege of Surgeons. Seminars on Occupational Injuries, 1973.

3. Ghosh P: Osteoarthritis and future prospects for management. SEAPALBulletin 6: 29-33, 1988.


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(viii) Patents

1. Cullis-Hill D and Ghosh P: Anti-inflammatory Compounds and Compositions,US 5,668,116, Sept 1997.

2. Roubin R and Ghosh P: "Matrix gene expression in chondrogenesis".Australian Patent Provisional Application no. PP 8197, 15 February 2002.Assigned to the University of Sydney and ADP Pharmaceuticals Pty. Limited.

3. Shen B and Ghosh P: Nutraceuticals for the treatment, protection andrestoration of connective tissues. International Publication Number: WO03/062279, (July 2003).

4. Ghosh P: Connective Tissue derived Polypeptides. International PublicationNumber: WO 2004/110475, (December 2004).

5. Ghosh P: Glycosaminoglycan peptides derived from connective tissues anduse thereof in the prevention of arthritis and other anti-inflammatoryconditions. Australian Patent Provisional Application 2004900250, (January2004)

(ix) Refereed and Published Conference Papers

1. Gale CA, Ghosh P, Robinson RG, Stephens RW, Swann JC, Taylor TKF andWebb J: The origins and relative distribution of lysosomal enzymes inrheumatoid and osteoarthritic fluids. Aust. N.Z. J. Med. 3: 59, 1975.

2. Harris P, Ghosh P and Taylor TKF: Studies on the level of polysaccharidasesof rat osteosarcoma cells in vitro and in vivo. Clin. Exp. Pharmacol. 2(1): 85,1975.

3. Horsburgh BA, McKenzie LS, Ghosh P and Taylor TKF: Actions of anti-inflammatory drugs on the synthesis of acid mucopolysaccharides in humanosteoarthritic cartilage in vitro. Clin. Exp. Pharmacol. 2(1): 88, 1975.

4. Ingman AM, Ghosh P and Taylor TKF: The rationale of meniscectomy inosteoarthritis and rheumatoid arthritis of the knee joint. J. Bone Joint Surg. Br.57(2)B: 250, 1975.

5. Stephens RW, Ghosh P and Taylor TKF: The inhibitory effects of anti-inflammatory drugs and cations on hyaluronic acid degradation by serum andpathological synovial fluid. Clin. Exp. Pharmacol. 2(1): 87, 1975.

6. Burkhardt D, Stephens RW, Ghosh P and Taylor TKF: The inhibition ofsynovial-fluid glycosidases in the rheumatoid joint by metallothiomalates.Biochem. Soc. Trans. 4: 1081, 1976.

7. Ghosh P, Bushell GR, Taylor TKF and Sutherland JM: Characterisation of theproteoglycans of the canine nucleus pulposus and annulus fibrosus. Trans.Orthop. Res. Soc. 2: 10, 1977.

8. Ghosh P, Taylor TKF, McKenzie LS and Horsburgh BA: Comparison of thesynthesis and levels of glycosaminoglycans in aged and osteoarthrotic hipcartilages. Trans. Orthop. Res. Soc. 2: 9, 1977.


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9. Ghosh P, Taylor TKF, Braund KG and Sutherland JM: The effects on thepartial excision of the dorsal vertebral elements (PEDVE) on disc composition- An experimental study. Trans. Orthop. Res. Soc. 2: 9, 1977.

10. Taylor TKF, Ghosh P, Bushell GR and Braund KG: The effects of spinalfusion on adjacent intervertebral disc in dogs - An experimental study. Trans.Scol. Res. Soc. 2: 208, Boston, USA, 1977.

11. Taylor TKF, Ghosh P, Bushell GR and Sutherland JM: Studies in idiopathicscoliosis. J Bone Joint Surg. Br. 60B: 291, 1978.

12. Ghosh P, Wilkins RD and Taylor TKF: Failure stress studies onmicrospecimens of human semi-lunar cartilages (menisci). Trans. Orthop.Res. Soc. 3: 316, 1978.

13. Ghosh P, Bushell GR, Sutherland JM and Taylor TKF: The matrix of thescoliotic disc - A consequence or determinant of spinal curvature? J. BoneJoint Surg. Br. 61B: 241, 1979.

14. Ghosh P, Knight J, Stephens RW, Bushell GR and Taylor TKF: NeutralProtease inhibitors from human intervertebral disc and femoral head cartilage.Trans. Orthop. Res. Soc. 4: 47, 1979.

15. Ghosh P, Taylor TKF, Bellenger CR, Pettit GD and Horsburgh B: The effect ofimmobilization on the regrowth of the knee joint semi-lunar cartilage(meniscus). Trans. Orthop. Res. Soc. 4: 104, 1979.

16. Ghosh P, Stephens RW, Knight J and Taylor TKF: The role of enzymeinhibitors in the pathogenesis of osteoarthrosis. J. Bone Joint Surg. Br. 62B:268, 1980.

17. Walton E, Stephens RW, Ghosh, P and Taylor TKF: Anti-inflammatory druginhibition of human polymorphonuclear leukocyte elastase and cathepsin G.Connect. Tissue Res. 7: 207, 1980.

18. Bellenger CR, Horsburgh B, Ghosh P, Taylor TKF and Pettit GD: Regrowth ofthe knee joint semi-lunar cartilage - The effects of immobilization onglycosaminoglycan distribution. Connect Tissue Res. 7: 199, 1980.

19. Hawke LJ, Upfold LI, Walton EA, Stephens RW, Ghosh P and Taylor TKF:Why is cartilage avascular and resistant to neoplastic invasion? Connect.Tissue Res. 7: 201, 1980.

20. Upfold LI, Walton EA, Hawke LJ, Stephens RW, Ghosh P and Taylor TKF:Serine protease inhibitors in human articular cartilage. Connect. Tissue Res.8: 145, 1980.

21. Walton EA, Upfold LI, Stephens RW, Ghosh P and Taylor TKF: The role ofserine protease inhibitors in normal and osteoarthrotic human articularcartilage. Symposium on: Osteoarthritis and inflammation. Semin. ArthritisRheum. Suppl. 1: 1980.

22. Walton EA, Stephens RW, Ghosh P, Taylor TKF, Havemann K and GramseM: Non-steroidal anti-inflammatory drugs (NSAIDs) and articular cartilageintegrity. Symposium on: Osteoarthritis and inflammation. . Semin. ArthritisRheum. Suppl. 1: 1980.


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23. Stephens RW, Ghosh P, Bellenger CR, Walton EA and Taylor TKF:Immobilization of sheep forelimb - A model for study of cartilageneovascularization. Connect. Tissue Res. 8: 143-144, 1980.

24. Ghosh P, Walton EA, Stephens RW, Golding JC and Taylor TKF: Inhibition ofangiogenesis. CSIRO Special Symposium Publication: The importance ofcopper in biology and medicine. pp 50-53, 1981.

25. Burkhardt D, Ghosh P and Taylor TKF: The effects of age and cell viability ofthe degradation of rabbit costal cartilage proteoglycans. Connect. Tissue Res.9: 204-205, 1982.

26. Ghosh P, Sutherland JM, Horsburgh BA, Taylor TKF, Bellenger CR and PettitG: The effects of post-operative immobilization and weight-bearing on theregrowth of fibrocartilage and degeneration of articular cartilage in the kneejoint of meniscectomized greyhounds. Connect. Tissue Res. 9: 207, 1982.

27. Golding JC, Ghosh P and Taylor TKF: The effects of polysulphatedpolysaccharides on the degradation of cartilage proteoglycans in anexperimental model of osteoarthritis in the rabbit. Connect. Tissue Res. 9:208-210, 1982.

28. Ghosh P, Sutherland JM, Taylor TKF, Bellenger CR and Pettit GD: Theeffects of post-operative joint immobilization on articular cartilagedegeneration following meniscectomy. J. Bone Joint Surg. Br. 65(5): 671,1983.

29. Taylor TKF and Ghosh P: Serum glycosaminoglycans in adolescent idiopathicscoliosis and the dilemma of school screening for spinal deformity. J. BoneJoint Surg. Br. 65(5): 675, 1983.

30. Ghosh P, Lesjak M and Taylor TKF: Characterisation and study of the serineproteinase inhibitors of normal aged and osteoarthrotic human articularcartilage. Connect. Tissue Res. 11: 339-340, 1983.

31. Andrews JL, Ghosh P, Cook I, Lentini A and Ternai B: Interaction ofpolysulphated carbohydrates with human granulocyte elastase (HGE),collagen and articular cartilage protein. Connect. Tissue Res. 11: 220-221,1983.

32. Frost LC and Ghosh P: Aggregation and degradation of rabbit articularcartilage proteoglycans following microtrauma to the joint capsule. Connect.Tissue Res. 11: 246, 1983.

33. Golding JC and Ghosh P: The inhibition effects of polysulphatedpolysaccharides on cartilage proteoglycan degradation in experimentalarthritis. Connect. Tissue Res. 11: 247, 1983.

34. Andrews JL, Ghosh P, Sutherland JM and Horsburgh BA: Uptake anddistribution of glycosaminoglycan polysulphate (Arteparon®) in theintervertebral disc, knee joint articular cartilage and meniscus. Connect.Tissue Res. 11: 240, 1983.

35. Ghosh P and Frost L: The aggregation and degradation of rabbit articularcartilage proteoglycans following intra-articular injection of saline. Trans.Orthop. Res. Soc. 8: 315, 1983.


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36. Ghosh P, Sutherland JM, Taylor TKF, Bellenger CR and Pettit GD: Theresponse of femoral head articular cartilage to altered load bearing producedby knee joint meniscectomy and immobilization. Trans. Orthop. Res. Soc. 8:245, 1983.

37. Ghosh P, Bellenger CR, Sutherland JM, Taylor TKF and Pettit GD: Theeffects of post-operative immobilization on articular degeneration followingmeniscectomy in dog. Aust. Vet. Pract. 13(1): 26-27, 1983.

38. O'Brien TX, Frost L, Ghosh P and Taylor TKF: Effects of glycosaminoglycanpolysulphate on the synthesis and degradation of articular cartilageproteoglycans. Clin. Res. 31: 46, 1983.

39. Burkhardt D and Ghosh P: Isolation and characterisation of growth factorsfrom aged human articular cartilage. First International Workshop on: Cell andcytokines in bone and cartilage. Davos, Switzerland, December 1985. Calcif.Tissue Int. 38 (Suppl.): S14, 1985.

40. Ghosh P: Biology and pathobiology of cartilage. In: Rheumatology 85. Eds.PM Brooks and JR York. Excerpta Medica International Congress, Series675, Amsterdam, The Netherlands, pp 101-103, 1985.

41. Ghosh P: Aetiology and mechanisms of cartilage degradation in osteoarthritis.In: Rheumatology 85. Eds. PM Brooks and JR York. Excerpta MedicaInternational Congress, Series 675, Amsterdam, The Netherlands, pp 167-171, 1985.

42. Taylor TKF, Andrews JL, Frost LC, Ghosh P and Berndt MD:Glycosaminoglycans in scoliosis. In: Scoliosis Prevention Proc. 7thSymposium. Eds. JO Warner and MH Mehta. Praeger Publishers, NY, pp 23-43, 1985.

43. Ghosh P, Cole T-C and Taylor TKF: Variation of proteoglycans of theintervertebral disc with ageing and degeneration. Trans. Orthop. Res. Soc.11: 421, 1986.

44. Ghosh P, Andrews JL, Lesjak M and Osborne R: Variation with ageing anddegeneration of the serine and cysteine proteinase inhibitors of humanarticular cartilage. Trans. Orthop. Res. Soc. 11: 478, 1986.

45. Ghosh P, Hannan N, Bellenger C and Taylor TKF: Reduction in damage toarticular cartilage after meniscectomy. Trans. Orthop. Res. Soc. 11: 283,1986.

46. Francis DJ, Ghosh P and Brooks P: A new experimental model for theevaluation of chondroprotective agents and other drugs. Trans. Orthop. Res.Soc. 13: 282, 1988.

47. Ghosh P: The role of mechanical and genetic factors in degeneration of thedisc - A review. Bull. Aust. Assoc. Musculoskeletal Med. 4: 22-26, 1988.

48. Ghosh P: The basic biochemistry of the intervertebral disc and its variationwith ageing and degeneration - A review. Bull. Aust. Assoc. MusculoskeletalMed. 4: 18-21, 1988.

49. Ghosh P: The role of mechanical and genetic factors in degeneration of thedisc. J. Man. Med. 5: 62-65, 1990.


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50. Ghosh P: Basic biochemistry of the intervertebral disc and its variation withageing and degeneration. J. Man. Med. 5: 48-51, 1990.

51. Ghosh P and Burkhardt D: The latent serine proteinases of normal anddegenerate (OA) human cartilage. Trans. Orthop. Res. Soc. 16: 198, 1991.

52. Read R, Ghosh P, Wells C, Burkhardt D and Armstrong S: Topographicalvariation in composition, PG-biosynthesis and swelling pressure of cartilagesof loaded tibio-femoral joints. Trans. Combined Meeting of Japanese,American and Canadian Orthop. Res. Societies, Banff, Canada, 21-23October 1991.

53. Read R, Armstrong S, Wilson D, Marshall R and Ghosh P: A new animalmodel of osteoarthritis in which the clinical effects, cartilage lesions andsubchondral bone changes can be readily correlated. Trans. CombinedMeeting of Japanese, American and Canadian Orthop. Res. Societies, Banff,Canada, 21-23 October 1991.

54. Melrose J, Ghosh P and Taylor TKF: Proteoglycan heterogeneity in the ovineintervertebral disc. Immunol. Cell Biol. 70: S19, 1992.

55. McAuley LP, Ghosh P and Taylor TKF: In vitro biosynthesis of proteoglycansby intervertebral disc cells entrapped in alginate beads - A new experimentalmodel. Immunol. Cell Biol. 70: S19, 1992.

56. Meyer-Carrive I, Smith M and Ghosh P: The effects of tiaprofenic acid andmisoprostol on cartilage proteoglycans and eicosanoids levels in the rabbitjoint immobilization model. Immunol. Cell Biol. 70: S20, 1992.

57. Collier SA and Ghosh P: Effects of transforming growth factor-b on meniscalfibrochondrocytes in vitro. Immunol. Cell Biol. 70: S20, 1992.

58. Burkhardt D, Ghosh P, Sun D, Read R and Armstrong S: The relative effectsof hyaluronan (Artz®) and pentosan polysulphate (Cartrophen®) on theglycosaminoglycans of articular cartilage in an ovine model of osteoarthritis.Immunol. Cell Biol. 70: S20, 1992.

59. Rodgers K, Melrose J, and Ghosh P: Purification of a serine proteinaseinhibitor from ovine articular cartilage. Immunol. Cell Biol. 70: S32, 1992.

60. Armstrong S, Read R, Wilson D and Ghosh P: The effects of exercise on thehistopathology of cartilage and bone in meniscectomised ovine knee joints -The effects of exercise. J. Bone Joint Surg. Br. 75B (Suppl. 1): 69, 1993.

61. Hope NGA, Ghosh P, Read R, Burkhardt D and Taylor TKF: The influence ofmoderate exercise on the composition of the knee joint meniscus. J. BoneJoint Surg. Br. 75B (Suppl. 1): 70, 1993.

62. Ghosh P, Melrose J, Holbert C, Taylor TKF, McPherson C and Bellenger C:Disc reconstitution after chymopapain chemonucleolysis is related to the doseused and the amount of proteoglycan present in the nucleus pulposus. J.Bone Joint Surg. Br. 75B (Suppl. 1): 70, 1993.

63. Melrose J, Ghosh P, Taylor TKF, Hall A, Osti OL, Vernon-Roberts B andFraser RD: A longitudinal study of the matrix changes induced in theintervertebral disc by surgical damage to the annulus fibrosus. J. Bone JointSurg. Br. 75B (Suppl. 1): 70, 1993.


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64. Ghosh P, Numata Y, Smith S, Read R, Armstrong S and Wilson D: Themetabolic response of articular cartilage to altered mechanical loadinginduced by exercise and medial meniscectomy. J. Bone Joint Surg. Br. 75B(Suppl. 1): 69. 1993.

65. Hope NGA, Ghosh P, Read R, Burkhardt D and Taylor TKF: Matrix changesinduced in the lateral meniscus after medial meniscectomy and exercise. J.Bone Joint Surg. Br. 75B (Suppl. 1): 72, 1993.

66. Little CB, Ghosh P and Bellenger C: Studies on articular cartilageproteoglycan metabolism in a lateral meniscectomy model of earlyosteoarthritis in sheep. J. Bone Joint Surg. Br. 75B (Suppl. 1): 72, 1993.

67. Ghosh P: The role of cartilage-derived antigens, pro-coagulant activity andfibrinolysis in the pathogenesis of osteoarthritis - A hypothesis. J. Bone JointSurg. Br. 75B (Suppl. 1): 73, 1993.

68. Collier SA and Ghosh P: Experimental meniscal repair: Studies of the healingof longitudinal lesions in the avascular midsubstance of sheep menisci. J.Bone Joint Surg. Br. 75B (Suppl. 1): 72, 1993.

69. Armstrong S, Read R and Ghosh P: Increased subchondral osteoidproduction seen in an animal model of osteoarthritis. J. Bone Joint Surg. Br.75B (Suppl. 1): 73, 1993.

70. Ghosh P and Collier S: The effects of transforming growth factor b (TGF-b) onthe biosynthesis of proteoglycans by meniscal fibrochondrocytes in vitro.Trans. Orthop. Res. Soc. 18: 735, 1993.

71. Little C, Ghosh P and Bellenger C: Meniscectomy increases aggrecan,decorin (PG-S2) and biglycan (PG-S1) metabolism in cartilage. Trans.Orthop. Res. Soc. 18: 707, 1993.

72. Armstrong S, Read R, Ghosh P and Wilson D: Meniscectomy increasessubchondral osteoid production in an animal model of osteoarthritis. Trans.Orthop. Res. Soc. 18: 706, 1993.

73. Little C and Ghosh P: Mechanical loading of articular cartilage is a majordeterminant of chondrocyte phenotypic expression. Trans. Orthop. Res. Soc.19: 489, 1994.

74. Rodgers K, Melrose J and Ghosh P: Ovine articular chondrocytes synthesisea serine proteinase the levels of which are increased by interleukin-1 but notby retinoic acid. Osteoarthritis Cartilage 2 (Suppl. 1): 49, 1994.

75. Anderson J, Bansal M and Ghosh P: Immune response and auto-immunity tocartilage antigens in osteoarthritis. Osteoarthritis Cartilage 2 (Suppl. 1): 55,1994.

76. Ghosh P, Bowman L, Smith MM and Numata Y: Mechanism of action ofpentosan polysulphate (PPS) a pleiotropic osteoarthritis drug (POD).Osteoarthritis Cartilage 2 (Suppl. 1): 55, 1994.

77. Edelman J, Smith MM, March L and Ghosh P: A double-blind placebo-controlled clinical study of a pleiotropic osteoarthritis drug (pentosanpolysulphate, Cartrophen®) in 105 patients with osteoarthritis (OA) of theknee and hip joints. Osteoarthritis Cartilage 2(Suppl. 1): 60, 1994.


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78. Ghosh P, Taylor TKF, McAuley L and Melrose J: The role of mechanicalfactors in disc degeneration. J. Bone Joint Surg. Br. 76B (Suppl. 1 & 3): 1994.

79. Little CB and Ghosh P: Mechanisms of articular cartilage degenerationfollowing meniscectomy. J. Bone Joint Surg. Br. 76B (Suppl. 1 & 3): 1994.

80. Collier SA and Ghosh P: The potential of TGF-b in supporting repair of theknee joint meniscus. J. Bone Joint Surg. Br. 76B (Suppl. 1 & 3): 1994.

81. Melrose J, Ghosh P, Taylor TKF, Moore R and Latham J: The catabolism ofaggrecan and biosynthesis of decorin and biglycan are increased in annularrim lesions. Trans. Orthop. Res. Soc. 20: 413, 1995.

82. Little C, Jacoby A and Ghosh P: Differential effect of TGF-b on proteoglycanssynthesis by chondrocytes from defined weight bearing regions of articularcartilage. Trans. Orthop. Res. Soc. 20: 370, 1995.

83. Ghosh P, Smith MM, Numata Y and Verbruggen G: Calcium pentosanpolysulphate (CaPPS) a novel pleiotropic osteoarthritis drug (POD). EULAR J.24 (Suppl. 3): E79, 1995.

84. Melrose J, Rosenbaum D, Ghosh P, Hughes CE and Caterson B: A simplifiedprotocol for the isolation of the G1, G1-G2 domains of aggrecan and detectionof their degradation products by MMP-2, 3 on Western blots using biotinylatedhyaluronan and monoclonal antibodies. Immunol. Cell Biol. 73: A15, 1995.

85. Little C, Ghosh P and Rose R: The metabolism of aggrecan and decorin butnot biglycan are altered in high weight bearing regions of equine articularcartilage by strenuous exercise. Immunol. Cell Biol. 73: A16, 1995.

86. Little C and Ghosh P: The response of chondrocytes from different jointregions to growth factors and interleukin-1. Immunol. Cell Biol. 73: A18, 1995.

87. Rodgers, K, Melrose J, Little C and Ghosh P: Expression of aggrecanaseactivity by chondrocytes in an ovine meniscectomy model of osteoarthritis.Immunol. Cell Biol. 73: A18, 1995.

88. Smith MM, Numata Y, Bowman L and Ghosh P: Ex vivo metabolism ofsynovial fibroblasts cultured from rabbits administered calcium pentosanpolysulphate (PS) - A new anti-osteoarthritic drug. Immunol. Cell Biol. 73:A20, 1995.

89. Pasquali Ronchetti I, Mori G, Quaglino (Jr) D and Ghosh P: Hyaluronan-phospholipid interactions: Causality or biological role? Immunol. Cell Biol. 73:A21, 1995.

90. Melrose J, Numata Y and Ghosh P: Biotinylated hyaluronan: A versatilesensitive probe capable of detecting nanogram levels of hyaluronan bindingproteins (hyaladherins) by Western-blotting. Immunol. Cell Biol. 73: A21,1995.

91. Adam N, Ghosh P and Swain M: Pentosan polysulphate (PPS) increases themolecular weight of hyaluronan and the rheological properties of synovial fluidin patients with osteoarthritis. Immunol. Cell Biol. 73: A21, 1995.

92. Burkhardt D, Bowman L and Ghosh P: The effects of interleukin-1 on cellviability, nitric oxide production and proteoglycan synthesis by ovine articularchondrocytes. Immunol. Cell Biol. 73: A27, 1995.


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93. Xu Q, Little C, Robinson B and Ghosh P: The effect of TGF-b1 on theexpression of aggrecan, decorin and biglycan by ovine chondrocytes.Immunol. Cell Biol. 73: A27, 1995.

94. Appleyard R, Ghosh P and Swain M: The topographic variation inbiomechanical properties of articular cartilage of ovine joints in relation to itsultrastructure. Immunol. Cell Biol. 73: A11, 1995.

95. Sun D, Smith MM, Numata Y, Bowman L, Smith S, Holbert C and Ghosh P:Studies on the effects of Cervusen® in a new rat model of arthritis. Immunol.Cell Biol. 73: A29, 1995.

96. Bowman L, Smith MM, Numata Y and Ghosh P: The in vitro effects of calciumpentosan polysulphate and interleukin-1 on rabbit synovial fibroblastmetabolism. Immunol. Cell Biol. 73: A29, 1995.

97. Numata Y, Smith MM, Sun D, Bowman L and Ghosh P: Pentosanpolysulphate attenuates tumour necrosis factor-a, nitric oxide and interleukin-6 production in a rat model of inflammatory arthritis. Immunol. Cell Biol. 73:A30, 1995.

98. Smith MM, Numata Y, Bowman L and Ghosh P: Calcium pentosanpolysulphate given orally to rabbits with inflamed knee joints abrogatesinterleukin-1 induced anti-interleukin-6 activity in ex vivo cultures of synovialfibroblasts. Arthritis Rheum. 38 (Suppl.): S372, 1995.

99. Little CB, Ghosh P and Rose R: Strenuous running decreases aggrecan butincreases decorin biosynthesis in radial facet cartilage of equine third carpal;bones. Trans. 2nd Combined Orthop. Res. Soc. 2: 332, 1995.

100. Ghosh P, Read R, Armstrong S, Holbert C and Sun D: High contact stressinduced by meniscectomy results in cartilage and synovial fluid changesconsistent with early osteoarthritis: A 2 year study in sheep. Trans. 2ndCombined Orthop. Res. Soc. 2: 57, 1995.

101. Little CB, Ghosh P and Rose R: Proteoglycan metabolism is altered in thirdcarpal bone radial facet articular cartilage in strenuously exercised horses.Vet. Surg. 24(5): 430, 1995.

102. Ghosh P: Site and mode of action of polysulphated polysaccharides inosteoarthritis. Osteoarthritis Cartilage 4: i-ii, 1996.

103. Smith MM, Numata Y, Bowman L and Ghosh P: Preservation of chondrocyteand synoviocyte metabolism (cytoprotection) by oral calcium pentosanpolysulphate in a lapine model of inflammatory arthritis. OsteoarthritisCartilage 4: ii-iii, 1996.

104. Edelman J, Anderson J and Ghosh P: Disease modification in osteoarthritis:relationship of macrophage procoagulant activity and haematalogicalparameters to symptoms in patients receiving pentosan polysulphate.Osteoarthritis Cartilage 4: iv-v, 1996.

105. Adam N, Ghosh P, Swain M, Rasaratnam I and Ryan P: The effects of intra-articular pentosan polysulphate (Cartrophen) on synovial fluid visco-elasticityand hyaluronan molecular weight in patients with gonarthritis. OsteoarthritisCartilage 4: vii, 1996.


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106. Rasaratnam I, Ryan P, Bowman L, Smith M and Ghosh P: A double-blindplacebo-controlled study of intra-articular pentosan polysulphate (Cartrophen)in patients with gonarthritis - Laboratory and clinical findings. OsteoarthritisCartilage 4: vi-vii, 1996.

107. Ghosh P: Hyaluronan and the biochemical lesions of osteoarthritis. Immunol.Cell Biol. 74: A9, 1996.

108. Little C, Smith S, Adam N and Ghosh P: Effects of hyaluronans of differentmolecular weight on cartilage and synovial changes in an ovine model ofosteoarthritis. Immunol. Cell Biol. 74: A11, 1996.

109. Ghosh P: Pleiotropic drugs in osteoarthritis - Roles on cartilage and onsubchondral bone. Clin. Rheumatol. 15(5): 545, 1996.

110. Verbruggen G, Veys EM, Ghosh P and Cullis-Hill D: Pentosan polysulphatetreatment in osteoarthritis. Serological parameters which could correlate withclinical response. Clin Rheumatol 15(5): 542, 1996.

111. Taylor TKF, Burkhardt D and Ghosh P: The influence of pelvic proximity onlumbar disc proteoglycan metabolism. J. Bone Joint Surg. 78-B Suppls II andIII: 107, 1996.

112. Ghosh P, Xu Q, Little C and Robinson B: Up-regulation of decorin mRNA incartilages of an ovine model of osteoarthritis. Trans. Orthop. Res. Soc. 22(1):171, 1997.

113. Melrose J, Ghosh P, Taylor TKF, Vernon-Roberts B, Latham J and Moore R:Biglycan and decorin synthesis is elevated in an ovine annular lesion model ofexperimental disc degeneration. J. Bone Joint Surg. 79-B(4S) Suppl: 416,1997.

114. Melrose J, Ghosh P, Caterson B and Hughes C: Detection of the G1 and G2globular domains of aggrecan and their MMP-2,3 degradation products byaffinity blotting using biotinylated hyaluronan. Trans. Orthop. Res. Soc. 22(2):468, 1997.

115. Little C, Ghosh P, Hughes C and Caterson B: Aggrecanase is involved in bothnormal and accelerated turnover of aggrecan in an ovine model ofosteoarthritis. Trans. Orthop. Res. Soc. 22(1): 170, 1997.

116. Ghosh P, Adam N, Anderson J, Smith M, Edelman J and Verbruggen G:Synovial fluid rheology and plasma markers as indices of disease activity inOA. Osteoarthritis Cartilage 5 (Suppl. A): 46, 1997.

117. Conaghan PG, Smith MM, Brooks P and Ghosh P: Effect of calciumxylopyranose polysulphate in an animal model of inflammation. OsteoarthritisCartilage 5 (Suppl. A): 62, 1997.

118. Appleyard R, Little C, Ghosh P, Smith S and Swain M: The effects ofintraarticular hyaluronan on patellar cartilage of an ovine model ofosteoarthritis. Matrix Biol. 16(2): 67, 1997.

119. Melrose J, Smith S, Ghosh P and Taylor TKF: Differential expression ofproteoglycan epitopes by ovine intervertebral disc cells cultured in alginatemicrospheres. J. Bone Joint Surg. [Br] 80-B (2S) Suppl II: 144, 1998.


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120. Pattison S, Melrose J, Ghosh P and Taylor TKF: Characterisation of theproteoglycans of the cervical intervertebral disc. J. Bone Joint Surg. [Br] 80-B(2S) Suppl II: 144, 1998.

121. Hwa S-Y, Burkhardt D, Little C and Ghosh P: Dynamic spatial and temporalchanges of subchondral bone in an ovine model of osteoarthritis. J. BoneJoint Surg. [Br] 80-B(Suppl II): 145, 1998.

122. Appleyard R, Ghosh P and Swain M: Studies on the biomechanical propertiesof patellar cartilage in an ovine model of osteoarthritis using finite elementanalysis and a novel indentation system. J. Bone Joint Surg. [Br] 80-B(SupplII): 144, 1998.

123. Melrose J, Ghosh P and Taylor TKF: Studies on the temporal and spatialexpression of the large aggrecan, versican-like and the small leucine richrepeat proteoglycans of the intervertebral disc. Trans. Orthop. Res. Soc.23(1): 188, 1998.

124. Melrose J, Smith S, Ghosh P and Taylor TKF: Differential expression ofproteoglycan epitopes by ovine intervertebral disc cells in calcium alginatemicrospheres. Int. J. Exp. Pathol. 79(5): A38-A39, 1998.

125. Ghosh P, Xu A and Little C: Modulation of matrix metalloproteinase activity inosteoarthritic cartilage by calcium xylopyranose polysulfate. Trans. CombinedOrthop. Res. Soc. 342, 1998.

126. Ghosh P: The metabolism in pathologic conditions of the spinal disc andfuture therapy. J. Jpn Orthop. Assoc. 3-HS41, 1998.

127. Ghosh P, Appleyard R and Swain M: Progressive changes induced incartilage of the patella-femoral and hip joints by lateral meniscectomy. J. JpnOrthop. Assoc. 2H-EL82, 1998.

128. Ghosh P: Osteoarthritis: Pathogenesis and treatment. Publication of the 5thASEAN Congress of Rheumatology / 3rd APLAR Symposium, Manila,Philippines, January 1998.

129. Ghosh P: Disease modifying osteoarthritis drugs. Publication of the 5thASEAN Congress of Rheumatology / 3rd APLAR Symposium, Manila,Philippines, January 1998.

130. Ghosh P: Effects of exercise on cartilage and bone metabolism. Publication ofthe 5th ASEAN Congress of Rheumatology / 3rd APLAR Symposium, Manila,Philippines, January 1998.

131. Ghosh P: Osteoarthritis: Pathogenesis and treatment. Publication of the 5thASEAN Congress of Rheumatology / 3rd APLAR Symposium, Manila,Philippines, January 1998.

132. Ghosh P: The cartilage and subchondral bone in osteoarthritis. APLAR J.Rheumatol. 2: 175-178, 1998.

133. Ghosh P, Engle M, Smith M and Read R: Piascledine-300 modulateschondrocyte hypertrophic response and matrix metalloproteinase activity in anovine model of osteoarthritis. XIV European League Against RheumatismCongress, SECC, Glasgow, Scotland, 6-11 June 1999.


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134. Smith MM, Ghosh P, Conaghan P and Numata Y: Calcium pentosanpolysulfate modulates cytokine, nitric oxide and disease activity in a newmodel of inflammatory arthritis. Osteoarthritis Cartilage 6 (Suppl. 1): 43, 1999.

135. Smith MM, Diaz M, van Dijk, Darvodelsky A and Ghosh P: Orallyadministered CaPPS modulates the effects of peripheral blood monocytesfrom normal and arthritic rabbits on the metabolism of proteoglycans in rabbitear cartilage explants. Osteoarthritis Cartilage 7 (Suppl. A): S20, 1999.

136. Appleyard R, Swain M and Ghosh P: Modification of the dynamic shearmodulus and phase lag properties of tibial plateau articular cartilage in anovine model of osteoarthritis by oral administration of calcium pentosanpolysulfate. Trans. Orthop. Res. Soc. 320, 2000.

137. Parker D, Smith SM, Hwa S-Y, Smith MM and Ghosh P: The effects ofovariectomy and estrogen treatment on cartilage integrity in an ovine model ofosteoarthritis. 5th World Congress on Osteoarthritis - OsteoArthritis ResearchSociety International, Barcelona, Spain, 4-7 October 2000. OsteoarthritisCartilage 8 (Suppl. B): S46, 2000.

138. Roubin R, Smith MM and Ghosh P: Oral administration of deer-antlercartilage reduces disease progression in a rat model of arthritis and containsnovel gene products which have chondrogenic potential. 5th World Congresson Osteoarthritis - OsteoArthritis Research Society International, Barcelona,Spain, 4-7 October 2000. Osteoarthritis Cartilage 8 (Suppl. B): S50, 2000.

139. Smith MM, Reichman LJA, Smith SM, Hwa S-Y and Ghosh P: Calciumpentosan polysulfate downregulates estrogen receptor presentation insynovial fibroblasts in an ovine model of osteoarthritis. 5th World Congress onOsteoarthritis - OsteoArthritis Research Society International, Barcelona,Spain, 4-7 October 2000. Osteoarthritis Cartilage 8 (Suppl. B): S55, 2000.

140. Smith MM, Engle JM, Hwa S-Y and Ghosh P: Estrogen replacement therapyrestores proteoglycan synthesis in patellar cartilage of osteoarthritic sheep.5th World Congress on Osteoarthritis - OsteoArthritis Research SocietyInternational, Barcelona, Spain, 4-7 October 2000. Osteoarthritis Cartilage 8(Suppl. B): S55, 2000.

141. Melrose J, Smith S, Little C, Kitson J, Hwa S-Y and Ghosh P: Repair ofannular disc lesions: Spatial and temporal localisation of TGF-beta, sPARC(osteonectin, BM-40), and FGF-2 are early responses in experimentallyinjured ovine discs. Trans. Orthop. Res. Soc. 47th Annual Meeting, p0896,2001.


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142. Hwa S, Smith M, Burkhardt D and Ghosh P: Oestrogen depletion provokessignificant vascular and matrix changes in the calcified cartilage andsubchondral bone of the femoral-tibial joints of aged ewes. Trans. Orthop.Res. Soc. 47th Annual Meeting, p0373, 2001.

143. Cake MA, Read RA, Hwa S-Y and Ghosh P: Glyceryl trinitrate increasessubchondral bone thickness and density in an ovine meniscectomy model ofosteoarthritis. 6th World Congress on Osteoarthritis - OsteoArthritis ResearchSociety International, Washington, DC, USA, 30 September - 3 October 2001.Osteoarthritis Cartilage 9 (Suppl. B): S54, 2001.

144. Smith MM, Cake M, Smith SM, Hwa S-Y, Burkhardt D and Ghosh P: Theeffects of calcium pentosan polysulfate on synovial pathology, nitric oxidesynthase expression and hyaluronan production in an ovine model ofosteoarthritis. 6th World Congress on Osteoarthritis - OsteoArthritis ResearchSociety International, Washington, DC, USA, 30 September - 3 October 2001.Osteoarthritis Cartilage 9 (Suppl. B): S4, 2001.

145. Hwa S-Y, Smith MM, Sambrook P and Ghosh P: The protective effects ofcalcium pentosan polysulfate on calcified cartilage integrity in the medialcompartment of joints of an ovine model of osteoarthritis. 6th World Congresson Osteoarthritis - OsteoArthritis Research Society International, Washington,DC, USA, 30 September - 3 October 2001. Osteoarthritis Cartilage 9 (Suppl.B): S13, 2001.

146. Cake M, Appleyard R, Read R, Ghosh P, Swain M and Murrell G: Effects oftopical glyceryl trinitrate on femoro-tibial articular cartilage and subchondralbone in normal and ovariectomized sheep. Trans. Orthop. Res. Soc. 48thAnnual Meeting, 0154, 2002.

147. Appleyard R, Burkhardt D, Ghosh P, Read R, Cake M, Swain MV and MurrellGAC: Topographical relationships between cartilage biochemical anddynamic biomechanical properties in an ovine model of osteoarthritis. Trans.Orthop. Res. Soc. 48th Annual Meeting, 0667, 2002.

148. Appleyard RC, Szomor ZL, Ghosh P, Swain MV and Murrell GAC: Loss ofproteoglycans from articular cartilage increases dynamic phase lag but doesnot affect shear modulus: Application of a novel arthroscopic indentationdevice. Trans. Orthop. Res. Soc. 48th Annual Meeting, 0396, 2002.

149. Ghosh P, Kipic B, Smith MM, Burkhardt D, Swain M, Cake M and Read R:The viscosity and elasticity of synovial fluids from osteoarthritic joints areimproved 5 weeks post treatment by 5 intra-articular injections of hyaluronanwith a molecular weight (MW) of 500 - 730 kDa but not by a preparation withMW of 3000 - 6900 kDa. European Congress of Rheumatology (EULAR)Annual Meeting, Stockholm, Sweden, 12-15 June 2002. Ann. Rheum. Dis. 61(Suppl. 1): 116-117, 2002.

150. Read R and Ghosh P: Intra-articular hyaluronan: A disease modifyingtherapy? APLAR J. Rheumatol. 5(1): A5-A6, 2002.

151. Ghosh P: The challenges associated with the biologic repair of cartilagedefects. APLAR J. Rheumatol. 5(1): A2-A3, 2002.

152. Oakley SP, Appleyard RC, Ghosh P, Szomor Z, Portek I, Kirkham B andLassere MN: The relationship between stiffness (shear modulus), thickness


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and histologic grading of cartilage using different scoring methods.OsteoArthritis Research Society International, Sydney, NSW, Australia, 22-25September 2002. Osteoarthritis Cartilage 10 (Suppl. A): S23[PS10], 2002.

153. Oakley SP, Ghosh P, Szomor Z, Portek I, Kirkham B and Lassere MN:Cellular and matrix changes exist throughout the stifle joint after medialmeniscectomy - Evaluation of responsiveness of a new histological method ofassessment. OsteoArthritis Research Society International, Sydney, NSW,Australia, 22-25 September 2002. Osteoarthritis Cartilage 10 (Suppl. A):S22[PS09], 2002.

154. Oakley SP, Ghosh P, Szomor Z, Portek I, Kirkham B and Lassere MN:Evaluation of reliability of a new histological method of assessingosteoarthritic cartilage. OsteoArthritis Research Society International, Sydney,NSW, Australia, 22-25 September 2002. Osteoarthritis Cartilage 10 (Suppl.A): S23[PO11], 2002.

155. Roubin R, Ghosh P, Robinson B, Goomer R and Amiel D: A novel geneproduct derived from deer antler chondrocytes stimulates mitogenesis whentransfected into rabbit chondrocytes. OsteoArthritis Research SocietyInternational, Sydney, NSW, Australia, 22-25 September 2002. OsteoarthritisCartilage 10 (Suppl. A): S41[PS64], 2002.

156. Cake MA, Read RA, Smith SM and Ghosh P: Ovariectomy increases nitricoxide production in ovine patellar cartilage. OsteoArthritis Research SocietyInternational, Sydney, NSW, Australia, 22-25 September 2002. OsteoarthritisCartilage 10 (Suppl. A): S9[M24], 2002.

157. Smith MM, Pradhananga S and Ghosh P: Calcium pentosan polysulfateincreases both concentration and molecular weight of hyaluronan synthesisedby human osteoarthritic synovial fibroblasts in vitro. OsteoArthritis ResearchSociety International, Sydney, NSW, Australia, 22-25 September 2002.Osteoarthritis Cartilage 10 (Suppl. A): S50[PS91], 2002.

158. Smith MM, Burkhardt D, Smith SM, Cake M, Read RA and Ghosh P: Theeffects of intraarticular hyaluronan on synovial pathology, nitric oxidesynthase expression and hyaluronan production in an ovine model ofosteoarthritis. OsteoArthritis Research Society International, Sydney, NSW,Australia, 22-25 September 2002. Osteoarthritis Cartilage 10 (Suppl. A):S55[PS107], 2002.

159. Smith MM, Ghosh P, Kipic B, Burkhardt D, Swain M, Cake M and Read R:The quantity and quality of hyaluronan in synovial fluids from osteoarthriticsheep are improved by intra-articular Hyalgan® treatment. OsteoArthritisResearch Society International, Sydney, NSW, Australia, 22-25 September2002. Osteoarthritis Cartilage 10 (Suppl. A): S56[PS108], 2002.

160. Shen B, Shimmon S, Smith MM and Ghosh P: Discovery and evaluation ofpotential disease modifying anti-osteoarthritis drugs using surface plasmonresonance technology. OsteoArthritis Research Society International, Sydney,NSW, Australia, 22-25 September 2002. Osteoarthritis Cartilage 10 (Suppl.A): S4[M09], 2002.

161. Hwa S-Y, Burkhardt D, Smith SM, Smith MM and Ghosh P: The protectiveeffects of calcium pentosan polysulfate on articular cartilage and subchondral


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bone in the medial compartment of joints in an ovine model of osteoarthritisinduced by lateral meniscectomy. OsteoArthritis Research SocietyInternational, Sydney, NSW, Australia, 22-25 September 2002. OsteoarthritisCartilage 10 (Suppl. A): S21[PS05], 2002.

162. Bagga H, Burkhardt D, Morris D, Ghosh P and March L: Effect of intra-articular hylan GF-20 (Synvisc) on synovial fluid and clinical parameters.OsteoArthritis Research Society International, Sydney, NSW, Australia, 22-25September 2002. Osteoarthritis Cartilage 10 (Suppl. A): S69[PS149], 2002.

163. Melrose J, Smith S, Ghosh P and Whitelock J: Perlecan, the multi-domain,heparan sulphate basal lamina proteoglycan, is also a prominent peri- andextra-cellular matrix component in the developing vertebral body andintervertebral disc of the foetal human spinal column. (submitted Orthop. Res.Soc. Meeting, February 2003).

164. Ghosh P, Shen B, Shimmon S and Smith M: A new technology for thediscovery and evaluation of anti-arthritic agents using surface plasmonresonance (SPR). APLAR J. Rheumatol. (accepted for publication).

165. Oakley SP, Szomor Z, Ghosh P, Portek I, Lassere MN, Kirkham BW, MurrellGAC and Appleyard R: Reduction in collagen organization and stiffnessduring early state osteoarthritis: A study in sheep. Trans. Orthop. Res. Soc.49th Annual Meeting, 2003.

166. Ghosh P, Shimmon S, Whitehouse M: A novel Glycosaminoglycanpolypeptide complex, Peptacan, suppresses joint inflammation anf preservescartilage in rat mosdels of arthritis given orally either as a toleragen or as atherapeutic agent. Osteoarthritis Cartilage 12 (Suppl. B): [P189], 2004.

167. Ghosh P, Shen B, Wei X,: Functional characterisation of the novel genehDACC-7 – A prologue for gene therapy for the repair of articular cartilage.Osteoarthritis Cartilage 12 (Suppl. B):[ M66], 2004.

168. Yet to be updated

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CV Professor Peter GHOSH