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Curriculum Vitae

Date Prepared: March 15, 2015

Name: Harald Paganetti

Office Address: Massachusetts General Hospital Department of Radiation Oncology

Frances H. Burr Proton Therapy Center Boston, MA 02114

Home Address: 29 Decatur Street Gloucester, MA 01930

Work Phone: 1-617 726-5847

Work Email: hpaganetti@partners.org

Work FAX: 1-617 724-0368

Place of Birth: Ochtendung, Germany

Education

1989 Masters (Diploma) Physics (Advisor: Prof. P. David)

Rheinische-Friedrich-Wilhelms University, Bonn, Germany

1992 PhD Physics (Advisor: Prof. P. David)

Rheinische-Friedrich-Wilhelms University, Bonn, Germany

Postdoctoral Training

02/94-01/97 Postdoctoral Fellow Microdosimetry Department of Medicine, Forschungszentrum Jülich, Jülich, Germany

02/97-01/98 Postdoctoral Fellow Eye-Tumor Proton therapy Department of Ion-Beam Applications, Hahn-Meitner Institute, Berlin, Germany

02/98-01/00 Research Fellow Radiation Oncology Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA

Faculty Academic Appointments

01/98-12/00 Research Fellow Radiation Oncology Harvard Medical School 01/01-03/02 Instructor Radiation Oncology Harvard Medical School 04/02-02/06 Assistant Professor Radiation Oncology Harvard Medical School 03/06-08/12 Associate Professor Radiation Oncology Harvard Medical School 09/12- Professor Radiation Oncology Harvard Medical School

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Appointments at Hospitals/Affiliated Institutions

01/98-03/02 Research Fellow Radiation Oncology Massachusetts General Hospital 04/02-02/06 Assistant Biophysicist Radiation Oncology Massachusetts General Hospital 03/06-08/12 Associate Biophysicist Radiation Oncology Massachusetts General Hospital 09/12- Biophysicist Radiation Oncology Massachusetts General Hospital 01/09- Director of Physics Research Radiation Oncology Massachusetts General Hospital

Other Professional Positions

06/93-01/94 Lecturer for computer software ZAM (Central Institute for Applied Microelectronics of the Bavarian Colleges), Munich, Germany

01/01-12/01 Lecturer; Dept. of Nuclear Engineering Massachusetts Institute of Technology (MIT), Cambridge, MA

Major Administrative Leadership Positions Local

01/09- Director of Physics Research Radiation Oncology Massachusetts General Hospital National and International

08/11-07/12 Program Director (Therapy) American Association of Physicists in Medicine (AAPM) 09/09-05/12 Member of the Executive

Committee International Organization for Medical Physics (IOMP)

Committee Service Local

2010- Member: Oversight Committee of the Harvard Medical Physics Residency Program

Harvard Medical School

2010-2013 Clinical Trials Advisory Group Massachusetts General Hospital; Department of Radiation Oncology

National and International

2005 Consultant: Committee on prescribing and reporting dose in proton therapy

International Commission on Radiological Units and Measurements (ICRU)

2009 Member: Technical Program Committee

World Congress on Medical Physics and Biomedical Engineering, Munich, Germany, 2009

2010 Member: Scientific Program Committee

Congreso Latinoamericano de Fisica Medica; Cusco, Peru 2010

2010-2011 Member: Scientific Program Committee

2011 Annual Meeting of the National Council on Radiation Protection and Measurements (NCRP) “Scientific and Policy Challenges of

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Particle Radiations in Medical Therapy and Space Missions”

2006-2011 Chair: Nuclear Data Committee on Heavy Charged Particle Data for Radiotherapy

International Atomic Energy Agency (IAEA)

2010-2015 Member: Committee / Working party “Radiation Protection in Charged Particle Radiotherapy”

International Commission on Radiological Protection (ICRP)

2010-2011 Member: Scientific Program Committee

18th International Conference on Medical Physics, Porto Alegre, Brazil, April 2011

2011-2012 Scientific Program Committee World Congress on Medical Physics and Biomedical Engineering, Beijing, China 2012

Member of the International Advisory Board 2011

Co-Chair of the Scientific Committee 2011-2012

2011-2012 Member: Scientific Program Committee

19th International Conference on Medical Physics, Brighton, UK, June 2013

2013 Member: Scientific Program Committee

2013 Annual Meeting of the Particle Therapy Co-Operative Group (PTCOG), Essen, Germany

2012- Member: National Council on Radiation Protection and Measurements (NCRP)

Professional Societies

2001- American Association of Physicists in Medicine (AAPM)

2001- Full member 2007-2009 Member, European Affairs Subcommittee 2007-2012 Member, Task Group No. 158 “Measurements

and Calculations of Out-of-Field Doses from External Beam Radiotherapy”

2009 Scientific Program Committee: “Symposium on the Promises and Perils of Proton Radiotherapy”, Baltimore, MD

2009 Course co-Director for Continuing Education for the 2009 Annual Meeting of the AAPM, Anaheim, CA

2008-2012 Member, Working Group on New Research Initiatives

2008-2010 Member, Joint Working Group for Research Seed Funding Initiative

2010-2013 Co-Chair, Joint Working Group for Research Seed Funding Initiative

2010-2011 Program Co-Director (Therapy): 53rd Annual Meeting of the AAPM (in combination with the annual meeting of the Canadian Organization of

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Medical Physics COMP), Vancouver, July 2011 2010-2012 Meeting Coordination Committee 2010-2012 Scientific Program Sub-Committee 2011-2012 Member, Working Group on Navigation and

Grantsmanship Education 2012- Vice-Chair, Working Group on Navigation and

Grantsmanship Education 2011-2012 Program Director (Therapy): 54th Annual

Meeting of the AAPM, Charlotte, July 2012 2012-2014 Member, Treatment Delivery Sub-Committee 2012- Member, Working Group on Particle Beams 2014- Chair, Task Group No. 256 on “Proton Relative

Biological Effectiveness” 2014- Course Director; 2015 AAPM Summer School:

Proton Therapy – Physical Principles and Practice

2006-2014 Full Member: American Physical Society (APS)

2010- Full Member: Radiation Research Society (RRS)

2009-2010 Particle Therapy Co-Operative Group (PTCOG)

2009-2010 Member, Task Group “Shielding Design and Radiation Safety of Charged Particle Therapy Facilities”

2009-2012 International Organization for Medical Physics (IOMP)

2009-2012 Chair, Science Committee 2009-2012 Member, Executive Committee 2010-2012 International Union of Pure and

Applied Physics (IUPAP)

2010-2012 Member, Affiliated Commission AC-4: International Commission on Medical Physics

2010-2012 Ex-officio member, U.S. Liaison Committee for the International Union of Pure and Applied Physics (USLC/IUPAP); The National Academies

2012- American Society for Therapeutic Radiology and Oncology (ASTRO)

2013- Associate member 2012 Member: Radiation Physics Committee (RPC) 2013- Member: Annual Meeting Scientific Committee 2013-2015 Co-Chair: Annual meeting Physics Track 2015- Chair: Annual meeting Physics Track 2013 Member: Multidisciplinary Q&A Subcommittee 2013-2015 Vice-Chair: Clinical, Translational and Basic

Science Advisory Committee

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2013-2015 Chair: Clinical, Translational and Basic Science Advisory Committee

2014- Member, Science Steering Committee Grant Review Activities

2003 Grant review committee American Institute of Biological Sciences (AIBS)

External reviewer 2003 2008 Grant review committee Dutch Cancer Society External reviewer 2008 2002-2010 Small Business Innovation Research

(SBIR) and Small Business Technology Transfer (STTR) study section

National Institute of Health (NIH) / National Cancer Institute (NCI)

Member 2002-2010 2000-2015 Radiation Therapeutics and Biology

(RTB) study section National Institute of Health (NIH) / National Cancer Institute (NCI)

Ad-hoc reviewer 2000-2002 Full Member 2011-2015 2011 Special emphasize study section:

Development of Multiscale Models (U01)

National Institute of Health (NIH) / National Institute of Biomedical Imaging and Bioengineering (NIBIB)

Ad-hoc reviewer 2012-2014 Fonds de la Recherche Scientifique -

FNRS Belgian Government Research Agency

External reviewer 2012-2014

Editorial Activities 1999-2013 Guest Associate Editor Medical Physics 2003 Special Issue Editor Technology in Cancer Research & Treatment 2003- Editorial Board Technology in Cancer Research & Treatment 2008-2013 Associate Editor BMC Medical Physics 2013- Editorial Board; Associate Senior

Editor International Journal of Radiation Oncology, Biology, Physics

2014- International Advisory Board Physics in Medicine and Biology

Honors and Prizes

2009 Roberts Prize finalist Institute of Physics (IoP)

The Robert Prize is honoring the best paper in Physics in Medicine and Biology in 2009 (Top 10 in 2009: Paganetti H: Dose to water versus dose to medium in proton beam therapy)

2010 Partners in Excellence Award Partners Healthcare 2012 Elected into the National Council NCRP (chartered

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on Radiation Protection and Measurements (NCRP)

by the U.S. Congress in 1964)

2012 Nominated for the 2011-2012 A. Clifford Barger Excellence in Mentoring Award

Harvard Medical School

2012 Honorary Masters Degree Harvard University 2013 2012-2013 A. Clifford Barger

Excellence in Mentoring Award Harvard Medical School

2014 Visiting Professor; Annual James A Purdy Medical Physics Lectureship

Washington University, St. Louis

2014 Fellow of the American Association of Physicists in Medicine (AAPM)

AAPM

Report of Local Teaching and Training Teaching of Students in Courses 1987-1989 Basic radiation physics (undergraduate students in

Physics, Biology, and Medicine); University of Bonn, Germany)

2-hr sessions per wk for 40 weeks

2000-2001 Fundamentals and applications of ionizing radiation (graduate students); Department of Nuclear Engineering at Massachusetts Institute of Technology (MIT), Cambridge, MA; Course number: 22.55J, HST.560J Syllabus: “Medical Uses of Ionizing Radiation I (Diagnostic)”, “Theoretical Macro-Dosimetry”, “Experimental Macro-Dosimetry”, “Theoretical Micro-Dosimetry”, “Experimental Micro-Dosimetry”, “Health Aspects Using Ionizing Radiation”, “Medical Uses of Ionizing Radiation II (Therapy)”

2-hr sessions per wk for 20 weeks

2001 Radiation Oncology Physics (undergraduate students); Northeastern University, Physics Department. Boston, MA Syllabus: “Monte Carlo calculation techniques in radiation therapy”

2-hrs sessions; 8 times

2007 Harvard/MIT HST graduate program; Course number: HST.187 Syllabus: “Monte Carlo dose calculation”

1 lecture; 2 hrs

2008 Harvard/MIT HST graduate program; Course number: HST.187 Syllabus: “Neutrons in particle therapy”, “Biological aspects of particle therapy”

2 lectures; 2 hrs each

2009 Harvard/MIT HST graduate program; Course number: HST.187 Syllabus: “Neutrons in particle therapy”, “Biological aspects of particle therapy”

2 lectures; 2 hrs each

2012, 2014 MIT Nuclear Engineering; graduate program; Radiation 1 lecture; 2hrs

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Biophysics 22.055 (also 22.55J and HST.560J) Formal Teaching of Residents, Clinical Fellows and Research Fellows (post-docs) 2000- 1st year Radiation Oncology Residents

Syllabus: “Atomic and nuclear physics” 4 hour lectures / year

2010- MGH Radiation oncology lecture: “Applying for NIH funding for physics projects”

2 lecture; 1hr each; annually

Laboratory and Other Research Supervisory and Training Responsibilities

2001- Supervision of post-doctoral research fellows in Radiation Oncology Physics

Daily mentorship

Report of Regional, National and International Invited Teaching and Presentations Invited Presentations and Courses Teaching Courses 2001 RBE values for proton beam therapy. A survey on RBE dependencies on physical and

biological parameters in vitro and in vivo. XXXV PTCOG (Particle Therapy Co-Operative Group; Annual meeting), Tsukuba, Japan 2005 Proton Beam Radiotherapy – The State of the Art. / Educational Course (CE credited) Annual Meeting of the American Association of Physicists in Medicine (AAPM); Seattle,

Washington 2006 The Monte Carlo method in radiation therapy. Course on Monte Carlo in Radiation Therapy, INFN, Catania, Italy 2006 Monte Carlo calculation of time-dependent problem in radiation oncology. Course on Monte Carlo in Radiation Therapy, INFN, Catania, Italy 2006 Proton Monte Carlo in the clinic. Course on Monte Carlo in Radiation Therapy, INFN, Catania, Italy 2007 Geant4 applications to proton radiation therapy. / IAEA Teaching course Workshop on Nuclear Data for Science and Technology: Medical Application;

International Centre for Theoretical Physics, Trieste, Italy 2007 Nuclear data impact on proton radiation therapy calculations. / IAEA Teaching course Workshop on Nuclear Data for Science and Technology: Medical Application;

International Centre for Theoretical Physics, Trieste, Italy 2007 The use of Monte Carlo methods in heavy charged particle radiation therapy. Annual Meeting of the American Physical Society (APS), Denver, CO 2007 Proton Therapy / Educational Course (CE credited) Annual Meeting of the American Association of Physicists in Medicine (AAPM);

Minneapolis, MI 2007 Technical Development in Proton Therapy. Satellite Symposium at the 49th Annual Meeting of the American Society for Therapeutic

Radiology and Oncology (ASTRO), Los Angeles, CA 2008 Monte Carlo methods in proton beam radiation therapy. / Educational Course (CE

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credited) Annual meeting of the American College of Medical Physics (ACMP), Seattle, WA 2008 Proton Therapy. / Educational Course (CE credited) Annual Meeting of the American Association of Physicists in Medicine (AAPM); Houston,

TX 2008 RBE in Proton Therapy. Annual Meeting of the Radiation Therapy Oncology Group (RTOG); Philadelphia, PA 2008 Monte Carlo calculations. Annual Meeting of the Particle Therapy Co-Operative Group, PTCOG-47, Jacksonville,

FL 2009 Proton RBE. Is 1.1 correct? PSI (Paul Scherrer Institute) Winter School on Proton Therapy, Bad Zurzach, Switzerland 2009 Biological Uncertainties in Proton (Ion) Therapy. AAPM Symposium on the Promises and Perils of Proton Radiotherapy, Baltimore, MD 2009 Biological Aspects of Heavy Charged Particle Radiation Therapy. / Educational Course

(CE credited) Annual Meeting of the American Association of Physicists in Medicine (AAPM); Anaheim,

CA 2009 The future of NIH research funding. / Educational Course (CE credited) Annual Meeting of the American Association of Physicists in Medicine (AAPM); Anaheim,

CA 2009 Estimating the risk for second cancers using computer simulations and epidemiological

models (CE credited) Annual Meeting of the American Society for Therapeutic Radiology and Oncology

(ASTRO), Chicago, IL 2010 Radiobiological considerations of proton and carbon ion beams. Satellite Symposium at the 52nd Annual Meeting of the American Society for Therapeutic

Radiology and Oncology (ASTRO), San Diego, CA 2010 How significant are RBE variations in proton therapy? PSI (Paul Scherrer Institute) Winter School on Proton Therapy, Bad Zurzach, Switzerland 2011 How significant are RBE variations in proton therapy? / Teaching course PSI (Paul Scherrer Institute) Winter School on Proton Therapy, Bad Zurzach, Switzerland 2011 NIH Navigation and Grantsmanship / Educational Course (CE credited) Annual Meeting of the American Association of Physicists in Medicine (AAPM);

Vancouver, Canada 2012 Proton Planning and Delivery Uncertainties - physics aspects - 2012 State of the Art Techniques in IMRT, IGRT, SBRT, Proton and Brachytherapy:

Emphasis on Quality and Safety. Educational course organized by the American Society for Radiation Oncology (ASTRO), Las Vegas, NV

2012 How significant are RBE variations in proton therapy? / Teaching course PSI (Paul Scherrer Institute) Winter School on Proton Therapy, Bad Zurzach, Switzerland 2013 How significant are RBE variations in proton therapy? / Teaching course PSI (Paul Scherrer Institute) Winter School on Proton Therapy, Bad Zurzach, Switzerland 2013 Particle Physics / Teaching course Annual Meeting of the Particle Therapy Co-Operative Group, PTCOG-52, Essen,

Germany 2013 Biological considerations in proton therapy

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Satellite Symposium on Proton Therapy at the Annual Meeting of the American Association of Physicists in Medicine (AAPM); Indianapolis, IN

2013 Grantsmanship for NCI R01 and R21 applications Annual Meeting of the American Association of Physicists in Medicine (AAPM);

Indianapolis, IN 2014 How significant are RBE variations in proton therapy? / Teaching course PSI (Paul Scherrer Institute) Winter School on Proton Therapy, Bad Zurzach, Switzerland 2015 Differences in photon and proton biology - Variations in RBE - / Teaching course PSI (Paul Scherrer Institute) Winter School on Proton Therapy, Bad Zurzach, Switzerland Scientific Presentations 1998 Biophysical Modeling of Radiation Effects for Proton Therapy Kernfysich Versneller Institut (KVI), Groningen, The Netherlands 1999 Monte Carlo simulations to calculate the physical and biological characteristics of

therapeutic proton beams Hahn-Meitner Institut, Berlin, Germany 1999 Monte Carlo simulations to calculate the physical and biological characteristics of

therapeutic proton beams Deutsches Krebsforschungszentrum (DKFZ, German Cancer Research Center),

Heidelberg, Germany 2003 Significance of RBE variations in proton therapy. 7th Biennial ESTRO Meeting on Physics and Radiation Technology for Clinical

Radiotherapy, European Society of Therapeutic Radiology and Oncology, Geneva, Switzerland

2004 Monte Carlo simulations for commissioning, quality assurance, absolute dosimetry and treatment planning at the Northeast Proton Therapy Center.

14th International Conference on the use of Computers in Radiation Therapy, Seoul, South Korea

2004 Monte Carlo simulations at the Northeast Proton Therapy Center in Boston Deutsches Krebsforschungszentrum (DKFZ, German Cancer Research Center),

Heidelberg, Germany 2004 Calculation of Proton RBE values. 23rd Annual ESTRO Meeting, European Society of Therapeutic Radiology and Oncology,

Amsterdam, Netherlands 2004 Dynamic Monte Carlo simulations for proton beam therapy. University of Texas, MD Anderson Cancer Center, Houston, TX 2004 RBE in proton therapy treatment planning. University of Texas, MD Anderson Cancer Center, Houston, TX 2006 Current 4D Monte Carlo Simulation Methods. Workshop at Johns Hopkins University on “Deformable and 4D Patient Modeling”;

Baltimore, Maryland 2006 Radiation Treatment Involving Moving Targets. Rensselaer Polytechnic Institute, Troy, New York 2006 Treatment planning in 3 and 4 dimensions and the role of Monte Carlo techniques. World Congress on Medical Physics and Biomedical Engineering; Seoul, South Korea 2006 Roadmap to clinical use of proton Monte Carlo. 1st European Workshop on Monte Carlo Treatment Planning; Gent, Belgium 2007 What is needed in order to implement RBE variations in proton therapy treatment

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planning? Fifteenth Annual Radiation Workshop at Round Top, Round Top, TX 2007 The need for benchmark studies related to proton therapy. Annual Meeting of the American Nuclear Society (ANS), Boston, MA 2007 Should we worry about neutrons? Annual Meeting of the American Association of Physicists in Medicine (AAPM);

Minneapolis, MI 2007 The risk associated with secondary neutron doses in radiation therapy. Meeting of the New England chapter of the American Association of Physicists in

Medicine (NEAAPM), Providence, RI 2008 Computer simulations for translational research in proton beam therapy. Annual workshop on image-guided radiation therapy and robotics, Mannheim, Germany 2009 Comparing pencil-beam generated and Monte Carlo generated dose-to-water and dose-to-

tissue distributions for proton therapy patients. World Congress on Medical Physics and Biomedical Engineering; Munich, Germany 2009 Simulating dose and cancer risk due to low-dose neutron background in proton therapy. World Congress on Medical Physics and Biomedical Engineering; Munich, Germany 2009 Clinical use of proton Monte Carlo. / Keynote lecture European Workshop on Monte Carlo Treatment Planning; Cardiff, Wales 2010 Methodologies for assessing second cancer risk from radiation therapy and the impact of

treatment plan and treatment modality. National Cancer Institute, Radiation Genetics and Epidemiology, Bethesda, MD 2010 The use of Monte Carlo methods in proton radiation therapy of cancer. 4th workshop on Monte Carlo methods, Heidelberg, Germany 2010 Predicting the risk of developing a radiation-induced second cancer when treating a

primary cancer with radiation. / Presidential Symposium Annual meeting of the Radiation Research Society, Maui, Hawaii 2010 Relative biological effectiveness in proton therapy. Ion Beams in Biology & Medicine (IBIBAM), International workshop, Berkeley, CA 2010 Dose, equivalent dose, and risk outside of the target in external beam radiation therapy. Annual meeting of the International Commission on Radiation Units and Measurements

(ICRU), Essen, Germany 2011 Current Challenges in Proton and Light Ion Therapy. / Keynote lecture International Conference on Medical Physics, Porto Alegre, Brazil 2011 Monte Carlo simulations to influence current margin settings in proton therapy Deutsches Krebsforschungszentrum (DKFZ, German Cancer Research Center),

Heidelberg, Germany 2011 Monte Carlo as a tool to reduce uncertainties for proton therapy treatments International Workshop on Recent Advances in Monte Carlo Techniques for Radiation

Therapy, Montreal, Canada 2011 Clinical significance of RBE variations in proton and carbon ion therapy (an

overview/introduction to the problem) (CE credited) Annual Meeting of the American Association of Physicists in Medicine (AAPM);

Vancouver, Canada 2011 Computational phantoms for estimating the risk for radiation-induced cancers in radiation

therapy The Third International Workshop on Computational Phantoms for Radiation Protection,

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Imaging and Radiotherapy, Tsinghua University, Beijing, China 2011 Proton Therapy and the Curse of Precision. University of Pennsylvania, Philadelphia, PA 2011 Assessment of the Risk for Developing a Second Malignancy from Scattered and

Secondary Radiation in Radiation Therapy Annual Meeting of the National Council on Radiation Protection and Measurements

(NCRP) “Scientific and Policy Challenges of Particle Radiations in Medical Therapy and Space Missions”, Bethesda, MD

2012 The potential of increasing the therapeutic ratio in proton therapy by considering RBE variations

University of Texas, MD Anderson Cancer Center, Houston, TX 2012 TOPAS: Tool for Particle Simulation University of Texas, MD Anderson Cancer Center, Houston, TX 2012 Remaining physics challenges in proton therapy Connecticut Area Medical Physics Society (CAMPS): Proton Therapy Symposium at Yale

School of Medicine 2012 Proton Monte Carlo simulations to reduce uncertainties in treatment planning and delivery Department of Radiation Medicine and Applied Sciences, University of California, San

Diego Health System 2012 Motion Management in Proton Beam Scanning World Congress on Medical Physics and Biomedical Engineering, Beijing, China 2012 Uncertainties When Predicting the Dose Delivered to Proton Therapy Patients / Keynote

lecture World Congress on Medical Physics and Biomedical Engineering, Beijing, China 2012 Do Uncertainties in Proton Therapy Limit Its Clinical Potential? Annual Meeting of the American Association of Physicists in Medicine (AAPM); Charlotte,

NC 2012 Accuracy of Proton Dose Computation Algorithms and Need for Improvements: Monte

Carlo Annual Meeting of the American Association of Physicists in Medicine (AAPM); Charlotte,

NC 2012 Physical and biological parameters influencing the RBE in proton therapy Annual meeting of the Radiation Research Society, Puerto Rico 2012 Physics challenges in order to exploit the full potential of proton therapy Grand rounds lecture, Henry Ford Hospital, Detroit 2013 High performance particle therapy ASTRO AAPM NCI workshop on Technology for Innovation in Radiation Oncology,

Bethesda, MD 2013 Range uncertainties in proton therapy Annual Meeting of the American Association of Physicists in Medicine (AAPM);

Indianapolis, IN 2014 Exploiting the physical and biological characteristics of proton beams in radiation

oncology Annual James A Purdy Medical Physics Lectureship; Washington University, St Louis,

MO 2014 Monte Carlo simulations for research as well as clinical support in proton therapy Workshop on Proton Therapy; National Physics Laboratory, London, UK

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2014 Application of Monte Carlo dose and effect calculations in proton therapy International Workshop on Monte Carlo Techniques in Medical Physics, Quebec City,

Canada 2014 Laboratory and Clinical Evidence for and Against a Spatially Invariant RBE Annual Meeting of the American Association of Physicists in Medicine (AAPM); Austin,

TX 2014 Clinical impact of Monte Carlo simulations in proton therapy International symposium on Photon, Proton, Carbon Ion Radiotherapy: Advances in

Basic, Translational, and Clinical Research: Colorado State University, Denver, CO 2014 Physics simulations to exploit the biological characteristics of proton beams in radiation

oncology Annual workshop on image-guided radiation therapy and robotics, Mannheim, Germany 2014 From dose to biological effect: Biological parameters in proton therapy treatment planning Annual Meeting of the Radiation Research Society; Las Vegas, NV Report of Clinical Activities and Innovations Practice Activities

2002-2008 Quality assurance measurements for proton radiation therapy treatments

Massachusetts General Hospital, FH Burr Proton Therapy Center

4 hours per week

Report of Education of Patients and Service to the Community Educational material or curricula developed for non-professional students 2010 Biophysics Annenberg Media (in collaboration with the Harvard

Smithsonian Institute): “Teacher professional development and classroom resources across the curriculum”: Physics of the 21st Century. Unit 9; Biophysics; http://www.learner.org/resources/series213.html

Report of Scholarship Books

1. “Proton Therapy Physics”: Ed. Harald Paganetti; Taylor & Francis / CRC Press 2012; ISBN-10: 1439836442

2. “Principles and Practice of Proton Beam Therapy”: (Eds. Indra J Das and Harald Paganetti); Medical Physics Monograph No. 37; Medical Physics Publishing, Madison, W; ISBN: 978-1-936366-43-9 2015, in press

Research Investigations and Editorials published in peer-reviewed journals

1. Schrieder W; David P; Hänscheid H; Konijn J; de Laat CTAM; Paganetti H; Petitjean C; Reist HW; Risse F; Rösel Ch; Schaller LA; Schellenberg L; Sinha AK; Taal A and Trautmann N: The probability of prompt and delayed fission of muonic 237Np. Zeitschrift für Physik A-Hadrons and Nuclei 1991: 339, 445-451

2. Paganetti H; David P; Hänscheid H; Konijn J; de Laat CTAM; Lourens W; Risse F; Rösel Ch;

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Schaller LA and Taal A: Radiationless transition probabilities in muonic 209Bi. Zeitschrift für Physik A-Hadrons and Nuclei 1992: 342, 245-246

3. Paganetti H; David P; Hänscheid H; Konijn J; de Laat CTAM; Lourens W; Risse F; Rösel Ch; Schaller LA and Taal A: Delayed muon induced fission of 209Bi and the role of meson-exchange currents. Zeitschrift für Physik A-Hadrons and Nuclei 1992: 343, 113-118

4. Rösel Ch; Hänscheid H; Hartfiel J; von Mutius R; d’Achard van Enschut JFM; David P; Janszen H; Johansson T; Konijn J; Krogulski T; de Laat CTAM; Paganetti H; Petitjean C; Polikanov SM; Reist HW; Risse F; Schaller LA; Schellenberg L; Schrieder W; Sinha AK; Taal A; Theobald JP; Tibell G and Trautmann N: The study of prompt and delayed muon induced fission. III. The ratios of prompt to delayed fission yields. Zeitschrift für Physik A 1993: 345, 89-93

5. Rösel Ch; Karpeshin FF; David P; Hänscheid H; Konijn J; de Laat CTAM; Paganetti H; Risse F; Sabirov B; Schaller LA; Schellenberg L; Schrieder W and Taal A: Experimental evidence for muonic X-rays from fission fragments. Zeitschrift für Physik A 1993: 345, 425-426

6. Paganetti H and Schmitz Th: The influence of the beam modulation technique on dose and RBE in proton radiation therapy. Physics in Medicine and Biology 1996: 41, 1649-1663

7. Paganetti H; Olko P; Kobus H; Becker R; Schmitz Th; Waligorski MPR; Filges D and Müller-Gärtner HW: Calculation of RBE for proton beams using biological weighting functions. International Journal of Radiation Oncology, Biology, Physics 1997: 37, 719-729

8. Becker R; Bienen J; Cloth P; Dellert M; Drüke V; Eyrich W; Filges D; Fritsch M; Hauffe J; Heinrichs U; Hoffmann W; Kobus H; Maier R; Moosburger M; Paganetti H; Paul N; Peterson HP; Schmitz Th; Schwenke K and Sperl R: Comparison of HETC and PTRAN with Phantom Measurement Data. Radiation Protection Dosimetry 1997: 70, 497-500

9. Becker R; Bienen J; Carl U; Cloth P; Dellert M; Drüke V; Eyrich W; Filges D; Fritsch M; Hauffe J; Hoffmann W; Kobus H; Maier R; Moosburger M; Paganetti H; Peterson HP; Schmitz Th; Schwenke K and Sperl R: Biophysical Investigations of Therapeutic Proton Beams. Radiation Protection Dosimetry 1997: 70, 485-492

10. Paganetti H: Calculation of the spatial variation of relative biological effectiveness in a therapeutic proton field for eye treatment. Physics in Medicine and Biology 1998: 43, 2147-2157

11. Paganetti H: Monte Carlo method to study the proton fluence for treatment planning. Medical Physics 1998: 25, 2370-2375

12. Gottschalk B; Platais R and Paganetti H: Nuclear interactions of 160 MeV protons stopping in copper: a test of Monte Carlo nuclear models. Medical Physics 1999: 26, 2597-2601

13. Paganetti H and Goitein M: Radiobiological significance of beam line dependent proton energy distributions in a spread-out Bragg peak. Medical Physics 2000: 27, 1119-1126

14. Paganetti H; Gerweck L and Goitein M: The general relation between tissue response to x-radiation (α/β-values) and the relative biological effectiveness (RBE) of protons: prediction by the Katz track structure model. International Journal of Radiation Biology 2000: 76, 985-998

15. Paganetti H and Goitein M: Biophysical modeling of proton radiation effects based amorphous track models: International Journal of Radiation Biology 2001: 77, 911-928

16. Paganetti H: Nuclear Interactions in Proton Therapy: Dose and Relative Biological Effect Distributions Originating From Primary and Secondary Particles. Physics in Medicine and Biology 2002: 47, 747-764

17. Paganetti H; Niemierko A; Ancukiewicz, M; Gerweck LE; Goitein M; Loeffler JS; and Suit HD: RBE values for proton beam therapy: International Journal of Radiation Oncology, Biology, Physics 2002: 53, 407-421

18. Paganetti H and Gottschalk B: Test of Geant3 and Geant4 nuclear models for 160 MeV protons stopping in CH2. Medical Physics 2003: 30, 1926-1931

19. Paganetti H: Hadron Therapy – From yesterday’s physics laboratory to today’s modern clinical

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routine. Technology in Cancer Research and Treatment 2003: 2, 353-354 20. Paganetti H: Significance and implementation of RBE variations in proton beam therapy.

Technology in Cancer Research and Treatment 2003: 2, 413-426 21. Suit H; Goldberg S; Niemierko A; Trofimov A; Adams J; Paganetti H; Chen GTY; Bortfeld T;

Rosenthal S; Loeffler J and Delaney T: Proton beams to replace photon beams in radical dose treatments. Acta Oncologica 2003: 42, 800-808

22. Flanz, J and Paganetti H: Monte Carlo calculations in support of the commissioning of the Northeast Proton Therapy Center. Australasian Physical & Engineering Sciences in Medicine 2003: 26. 156-161

23. Paganetti H: Four-dimensional Monte Carlo simulation of time dependent geometries. Physics in Medicine and Biology 2004: 49, N75-N81

24. Paganetti H; Jiang H; Lee S-Y and Kooy H: Accurate Monte Carlo simulations for nozzle design, commissioning, and quality assurance in proton radiation therapy. Medical Physics 2004: 31, 2107-2118

25. Jiang H and Paganetti H: Adaptation of GEANT4 to Monte Carlo dose calculations based on CT data. Medical Physics 2004: 31, 2811-2818

26. Paganetti H; Jiang H; Adams JA; Chen GT and Rietzel E: Monte Carlo simulations with time-dependent geometries to investigate organ motion. International Journal of Radiation Oncology, Biology, Physics 2004: 60, 942-950

27. Paganetti H; Jiang H and Trofimov A: 4D Monte Carlo simulation of proton beam scanning: Modeling of variations in time and space to study the interplay between scanning pattern and time-dependent patient geometry. Physics in Medicine and Biology: 2005: 50, 983-990

28. Paganetti H: Interpretation of proton relative biological effectiveness using lesion induction, lesion repair and cellular dose distribution. Medical Physics 2005: 32, 2548-2556

29. Jiang H; Wang B; Xu XG; Suit HD and Paganetti H: Simulation of patient organ doses and effective doses originating from secondary neutrons in proton beam treatment. Physics in Medicine and Biology 2005: 50, 4337-4354

30. Paganetti H: Changes in tumor cell response due to prolonged dose delivery times in fractionated radiation therapy. International Journal of Radiation Oncology, Biology, Physics 2005: 63, 982-990

31. Kooy HM; Rosenthal SJ; Engelsman M; Mazal A; Slopsema RL; Paganetti H; Bussiere M and Flanz JB: Prediction of output factors for spread-out proton Bragg peak fields in clinical practice. Physics in Medicine and Biology 2005: 50, 5847-5856

32. Emfietzoglou D; Paganetti H; Papamichael G and Pathak A: Monte Carlo calculation of nanoscale dosimetric distributions of MeV proton tracks with secondary electron transport. Nuclear Instruments and Methods B 2006: 245, 80-84

33. Paganetti H: Monte Carlo calculations for absolute dosimetry to determine output factors for proton therapy fields. Physics in Medicine and Biology 2006: 51, 2801-2812

34. Paganetti H; Bortfeld T and Delaney T: Re: neutron dose in proton radiation therapy: In regard to Eric J Hall (Int J Radiat Oncol Biol Phys 2006;65:1-7). International Journal of Radiation Oncology, Biology, Physics 2006: 66, 1594-1595

35. Bortfeld T and Paganetti H: The biological relevance of daily dose variations in adaptive treatment planning. International Journal of Radiation Oncology, Biology, Physics 2006: 64, 899-906

36. Suit H; Goldberg S; Niemierko A; Ancukiewicz M; Hall E; Goitein M; Wong W and Paganetti H: Secondary Carcinogenesis in Radiation Treated Patients. A Review of Data on Radiation Induced Cancers in Human, non Human Primate, Canine and Rodent Subjects. Radiation Research 2007: 167, 12-42

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37. Parodi K; Paganetti H; Cascio E; Flanz JB; Bonab AA; Alpert NM; Lohmann K and Bortfeld T: PET/CT imaging for treatment verification after proton therapy - a study with plastic phantoms and metallic implants. Medical Physics 2007: 34, 419-435

38. Seco J; Sharp GC; Turcotte J; Gierga D; Bortfeld T and Paganetti H: Effects of intra-fraction motion on IMRT treatments with segments of few monitor units. Medical Physics 2007: 34, 923-934

39. Paganetti H: Letter to the Editor concerning “The impact of protons on the incidence of second malignancies in radiotherapy” by Eric J. Hall (Technology in Cancer Research and Treatment 2007; 6, 31-34). Technology in Cancer Research and Treatment 2007: 6, 661-662

40. Jiang H; Seco J and Paganetti H: Effects of Hounsfield number conversions on patient CT based Monte Carlo proton dose calculation. Medical Physics 2007: 34, 1439-1449

41. Parodi K; Paganetti H; Shih H; Michaud S; Loeffler JS; Delaney TF, Liebsch NJ; Munzenrider JE; Fischman AJ; Knopf A and Bortfeld T: Patient study on in-vivo verification of beam delivery and range using PET/CT imaging after proton therapy. International Journal of Radiation Oncology, Biology, Physics 2007: 68, 920-934

42. Parodi K; Ferrari A, Sommerer T and Paganetti H: Clinical CT-based calculations of dose and positron emitter distributions in proton therapy using the FLUKA Monte Carlo code. Physics in Medicine and Biology 2007: 52, 3369-3388

43. Seco J; Sharp GC, Wu Z; Gierga D; Buettner F and Paganetti H: Dosimetric impact of motion in free-breathing and gated lung radiotherapy: a 4D Monte Carlo study of intra/inter fraction effects. Medical Physics 2008: 35, 356-366

44. Zacharatou Jarlskog C; Lee C; Bolch WE; Xu XG and Paganetti H: Assessment of organ specific neutron equivalent doses in proton therapy using computational whole-body age-dependent voxel phantoms. Physics in Medicine and Biology 2008: 53, 693-717

45. Suit H; Kooy H; Trofimov A; Farr J; Munzenrider J; Delaney T; Loeffler J; Clasie B; Safai S; Liebsch N and Paganetti H: Should positive phase III clinical trial data be required before proton beam therapy is more widely adopted? No. Radiotherapy & Oncology 2008: 86, 148-153

46. Parodia K; Bortfeld T; Enghardt W; Fiedler F; Knopf A; Paganetti H; Pawelke J; Shakirin G and Shih H: PET imaging for treatment verification of ion therapy. Nuclear Instruments and Methods A 2008: 591, 282-286

47. Zacharatou Jarlskog C and Paganetti H: Physics settings for using the Geant4 toolkit in proton therapy. IEEE Transactions in Nuclear Science 2008: 55, 1018-1025

48. Knopf A; Paganetti H; Bortfeld T; Cascio E and Parodi K: Quantitative assessment of the physical potential of proton beam range verification with PET/CT. Physics in Medicine and Biology 2008: 53, 4137-4152

49. Zacharatou Jarlskog C and Paganetti H: Sensitivity of different dose scoring methods on organ specific neutron doses calculations in proton therapy. Physics in Medicine and Biology 2008: 53, 4523-4532

50. Xu XG; Bednarz B and Paganetti H: A Review of Clinical Data and Radiation Dosimetry Methods on Secondary Cancers from External Beam Radiation Treatments. Physics in Medicine and Biology 2008: 53, R193-R241; Featured article; One of the 5 most cited papers in Physics in Medicine and Biology in 2008 and 2009; Listed within the top 20 highlights in Physics in Medicine and Biology in 2008

51. Zacharatou Jarlskog C and Paganetti H: The risk of developing second cancer due to neutron dose in proton therapy as a function of field characteristics, organ, and patient age. International Journal of Radiation Oncology, Biology, Physics 2008: 69, 228-235; Named one of the issue highlights

52. Paganetti H; Jiang H; Parodi K; Slopsema R; and Engelsman M: Clinical implementation of

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Monte Carlo dose calculation in proton beam therapy. Physics in Medicine and Biology 2008: 53, 4825-4853

53. Riboldi M; Chen GTY; Baroni G; Paganetti H and Seco J: Design and testing of a simulation framework for dosimetric motion studies integrating an anthropomorphic computational phantom into four-dimensional Monte Carlo. Technology in Cancer Research and Treatment 2008: 7, 449-456

54. Paganetti H: Dose to water versus dose to medium in proton beam therapy. Physics in Medicine and Biology 2009: 54, 4399-4421; Featured article; Nominated (one of 10) for the Roberts Prize (best paper in Physics in Medicine and Biology in 2009)

55. Knopf A; Parodi K; Bortfeld T; Shih HA and Paganetti H: Biological and physical limitations of proton beam range verification with offline PET/CT scans. Physics in Medicine and Biology 2009: 54, 4477-4495

56. Seco J; Robertson D; Trofimov A and Paganetti H: Breathing interplay effects during proton beam scanning: simulation and statistical analysis. Physics in Medicine and Biology 2009: 54, N283-N294

57. Daartz J; Engelsman M; Paganetti H and Bussière MR: Field Size Dependence of the Output Factor in Proton Therapy. Medical Physics 2009: 36, 3205-3210

58. Athar B and Paganetti H: Neutron equivalent doses and associated lifetime cancer incidence risks for head & neck and spinal proton therapy. Physics in Medicine and Biology 2009: 54, 4907-4926

59. Brenner DJ; Elliston CD; Hall EJ and Paganetti H: Reduction of the secondary neutron dose in passively-scattered proton radiotherapy, using an optimized pre-collimator / collimator. Physics in Medicine and Biology 2009: 54, 6065-6078

60. Paganetti H; Athar B and Bednarz B: Dose rate effects when estimating risks for second malignancies: In regard to Fontenot et al (Int. J. Radiat. Oncol. Biol. Phys. 2009;74:616-22). International Journal of Radiation Oncology, Biology, Physics 2009: 75, 162

61. Henkner K; Sobolevsky N and Paganetti H: Test of the nuclear interaction model in SHIELD-HIT and a dose comparison with GEANT4. Physics in Medicine and Biology: 2009: 54, N509-N518

62. Paganetti H: The use of computational patient models to assess the risk of developing radiation-induced cancers from radiation therapy of the primary cancer. Proceedings of the IEEE 2009: 97, 1977-1987

63. Paganetti H; Goitein M and Parodi K: Practical anti-proton beams show poor dose distributions for radiation therapy. Radiotherapy & Oncology 2010: 95, 79-86

64. McGurk R; Seco J; Riboldi M; Wolfgang J; Segars P and Paganetti H: Extension of the NCAT phantom for the investigation of intra-fraction respiratory motion in IMRT using 4D Monte Carlo. Physics in Medicine and Biology 2010: 55, 1475-90

65. Xu XG and Paganetti H: Better radiation weighting factors for neutrons generated from proton treatment are needed. Radiation Protection Dosimetry 2010: 138, 291-294

66. Clasie B; Wroe A; Kooy H; Depauw N; Flanz J; Paganetti H and Rosenfeld A: Assessment of out-of-field absorbed dose and equivalent dose in proton fields. Medical Physics 2010: 37, 311-321

67. Sarfehnia A; Stewart K; Ross CK.; McEwen MR; Clasie B; Chung E; Lu HM; Flanz J; Cascio E; Engelsman M; Paganetti H and Seuntjens J: Primary water calorimetry in clinical electron beams, scanned proton beams, and 192Ir brachytherapy dosimetry. Proceedings of the International Symposium on Standards, Applications and Quality Assurance in Medical Radiation Dosimetry (IDOS): 2010: 1, 87-98

68. Suit H; Delaney T; Goldberg S; Paganetti H; Clasie B; Gerweck L; Niemierko A; Hall E; Flanz

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J; Hallman J and Trofimov A: Proton vs carbon ion beams in the definitive radiation treatment of cancer patients. Radiotherapy and Oncology: 2010 95, 3-22

69. Paganetti H and Kooy H: Proton radiation in the management of localized cancer. Expert Review of Medical Devices 2010: 7, 275-285

70. Athar B; Bednarz B; Seco J; Hancox C and Paganetti H: Comparison of out-of-field photon doses in 6-MV IMRT and neutron doses in proton therapy for adult and pediatric patients. Physics in Medicine and Biology 2010: 55, 2879-2892

71. Sarfehnia A; Clasie B; Chung E; Lu HM; Flanz J; Cascio E; Engelsman M; Paganetti H and Seuntjens J: Direct absorbed dose to water determination based on water calorimetry in scanning proton beam delivery. Medical Physics 2010: 37, 3541-3550

72. Gensheimer MF; Yock TI; Liebsch NJ; Sharp GC; Madan N; Grant PE; Paganetti H and Bortfeld T: In vivo proton beam range verification using spine MRI changes. International Journal of Radiation Oncology, Biology, Physics 2010: 78, 268-275

73. Carabe-Fernandez A; Dale RG; Hopewell JW; Jones B and Paganetti H: Fractionation effects in particle radiotherapy: implications for hypo-fractionation regimes. Physics in Medicine and Biology: 2010 55:5685-5700

74. Bednarz B; Daartz J and Paganetti H: Dosimetric accuracy of planning and delivering small proton therapy fields. Physics in Medicine and Biology 2010 55:7425-7438

75. España S and Paganetti H: The impact of uncertainties in the CT conversion algorithm when predicting proton beam ranges in patients from dose and PET-activity distributions. Physics in Medicine and Biology 2010 55: 7557-7572

76. Knopf A; Parodi K; Paganetti H; Bortfeld T; Daartz J: Engelsman M; Liebsch N and Shih HA: Accuracy of proton beam range verification using post-treatment positron emission tomography/computed tomography as function of treatment site. International Journal of Radiation Oncology, Biology, Physics 2011: 79, 297-304

77. Athar BS and Paganetti H: Comparison of second cancer risk due to out-of-field doses from 6-MV IMRT and proton therapy based on 6 pediatric patient treatment plans. Radiotherapy and Oncology 2011: 98:87-92

78. Moteabbed M; España S and Paganetti H: Monte Carlo patient study on the comparison of prompt gamma and PET imaging for range verification in proton therapy. Physics in Medicine and Biology 2011 56:1063-1082

79. Carabe-Fernandez A; Dale RG and Paganetti H: Repair kinetics considerations in particle beam radiotherapy. British Journal of Radiology 2011 84: 546-555

80. Grassberger C; Trofimov A; Lomax A and Paganetti H: Variations in linear energy transfer within clinical proton therapy fields and the potential for biological treatment planning. International Journal of Radiation Oncology, Biology, Physics 2011 80: 1559-1566; Named one of the issue highlights

81. Espana S; Zhu X; Daartz J; El Fakhri G; Bortfeld T and Paganetti H: Study of the reliability of the cross sections used to model the production of PET isotopes with proton beams. Physics in Medicine and Biology 2011 56: 2687-2698; Featured article

82. Bednarz B; Lu HM; Engelsman M and Paganetti H: Uncertainties and correction methods when modeling passive scattered proton therapy treatment heads with Monte Carlo. Physics in Medicine and Biology 2011 56: 2837-2854

83. Espana S and Paganetti H: Uncertainties in planned dose due to the limited voxel size of the planning CT when treating lung tumors with proton therapy. Physics in Medicine and Biology 2011 56: 3843-3856

84. Bednarz B; Chen GTY; Paganetti H; Han B; Ding A and Xu GX: Comparison of particle-tracking features in Geant4 and MCNPX codes for applications in mapping of proton range

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uncertainty. Nuclear Technology 2011 175: 2-5 85. Depauw N; Danto S; Bednarz B; Paganetti H; Fink Y and Seco J: Preliminary Study of Proton

Radiography Imaging Qualities Using GEANT4 Monte Carlo Simulations. Nuclear Technology 2011 175: 6-10

86. Seco J; Depauw N; Danto S; Paganetti H and Fink Y: Qualitative Evaluation of Proton Radiography for Viewing Density Differences in Lung Tumors: A Monte Carlo Study. Nuclear Technology 2011 175: 27-31

87. Rinaldi I; Ferrari A; Mairani A; Paganetti H; Parodi K and Sala P: An integral test of FLUKA nuclear models with 160 MeV proton beams in Multi Layer Faraday Cups. Physics in Medicine and Biology 2011 56: 4001-4012

88. Zhu X; España S; Daartz J; Liebsch N; Ouyang J; Paganetti H; Bortfeld TR and El Fakhri G: Proton beam range verification with in-room PET imaging. Physics in Medicine and Biology 2011 56: 4041-4057

89. Attanasi F; Knopf A; Parodi K; Paganetti H; Bortfeld T; Rosso V and Del Guerra A: Extension and validation of an analytical model for in-vivo PET verification of proton therapy - a phantom and clinical study. Physics in Medicine and Biology 2011 56: 5079-5098; Featured article

90. Grassberger C and Paganetti H: Elevated LET components in clinical proton beams. Physics in Medicine and Biology 2011 56: 6677-6691

91. Remmele S; Hesser J; Paganetti H and Bortfeld T: A deconvolution approach for PET-based dose reconstruction in proton radiotherapy. Physics in Medicine and Biology 2011, 56: 7601-7619

92. Akagi T; Aso T; Faddegon B; Kimuar A; Matsufuji N; Nishio T; Omachi C; Paganetti H; Perl J; Sasaki T; Sawkey D; Schümann J; Sin J; Toshito T; Yamashita T and Yoshida H: The PTSim and TOPAS Projects, Bringing Geant4 to the Particle Therapy Clinic. Progress in Nuclear Science and Technology 2011 2: 912-917

93. Moteabbed M; Geyer A; Drenkhahn R; Bolch WE and Paganetti H: Comparison of whole-body phantom designs to estimate organ equivalent neutron doses for secondary cancer risk assessment in proton therapy. Physics in Medicine and Biology 2012 57: 499-515

94. Carabe A; Moteabbed M; Depauw N; Schuemann J and Paganetti H: Range uncertainty in proton therapy due to variable biological effectiveness. Physics in Medicine and Biology 2012 57: 1159–1172; Featured article; Top 10 of the most downloaded papers in Physics in Medicine and Biology in 2012

95. Efstathiou JA; Paly JJ; Lu HM; Athar BS; Moteabbed M; Niemierko A; Adams JA; Bekelman JE; Shipley WU; Zietman AL and Paganetti H: Adjuvant Radiation Therapy for Early Stage Seminoma: A Proton-Photon Treatment Planning Comparison. Radiotherapy and Oncology 2012 103: 12-17

96. Dowdell SJ; Clasie B; Depauw N; Metcalfe P; Rosenfeld AB; Kooy HM; Flanz JB and Paganetti H: Monte Carlo study of the potential reduction in out-of-field dose using a patient-specific aperture in pencil beam scanning proton therapy. Physics in Medicine and Biology 2012 57: 2829-2842; Featured article; Nominated (one of 10) for the Roberts Prize (best paper in Physics in Medicine and Biology in 2012). Named one of the 25 highlight papers in Physics in Medicine and Biology in 2012; Highlighted by “International Journal of Radiation Oncology, Biology, Physics” as one of the 4 most impact and outstanding Physics in Oncology papers among all relevant radiation oncology journals in 2012.

97. Paganetti H: Range uncertainties in proton therapy and the role of Monte Carlo simulations. Physics in Medicine and Biology 2012 57: R99-R117; Top 10 of the most downloaded papers in Physics in Medicine and Biology in 2012; Named one of the 25 highlight papers in Physics in Medicine and Biology in 2012

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98. Schuemann S; Paganetti H; Shin J; Faddegon BA and Perl J: Efficient voxel navigation for proton therapy dose calculation in TOPAS and Geant4. Physics in Medicine and Biology 2012 57: 3281-3293

99. Shin J; Perl J; Schuemann S; Paganetti H and Faddegon BA: A modular method to handle multiple time-dependent quantities in Monte Carlo simulations. Physics in Medicine and Biology 2012 57: 3295-3308

100. Paganetti H; Athar BS; Moteabbed M; Adams JA; Schneider U and Yock TI: Assessment of radiation induced second cancer risks in proton therapy and IMRT for organs inside the primary radiation field. Physics in Medicine and Biology 2012 57: 6047-6062

101. Titt U; Bednraz B and Paganetti H: Comparison of MCNPX and Geant4 proton energy deposition predictions for clinical use. Physics in Medicine and Biology 2012 57: 6381-6394

102. Paganetti H: Assessment of the risk for developing a second malignancy from scattered and secondary radiation in radiation therapy. Health Physics 2012 103: 652-661

103. Butterworth KT; McGarry CK; Clasie B; Carabe-Fernadez A; Schuemann J; Depauw N; Tang S; McMahon SJ; Schettino G; O’Sullivan JM; Lu HM; Kooy H; Paganetti H; Hounsell AR; Held KD and Prise KM: Cell survival responses to modulated proton beams delivered by passive scattering and pencil beam scanning. Physics in Medicine and Biology 2012 57: 6671-6680

104. Perl J; Shin J; Schuemann S; Faddegon BA and Paganetti H: TOPAS - An innovative proton Monte Carlo platform for research and clinical applications. Medical Physics 2012 39: 6818-6837

105. Jia X; Schuemann J; Paganetti H and Jiang SB: GPU-based fast Monte Carlo dose calculation for proton therapy. Physics in Medicine and Biology 2012 57: 7783-7798; Featured article

106. Besemer A; Paganetti H and Bednarz B: Clinical impact of uncertainties in the mean excitation energy of human tissues during proton therapy. Physics in Medicine and Biology 2013 58: 887-902

107. Min CH; Zhu X; Winey BA; Grogg K; Testa M; El Fakhri G; Bortfeld TR; Paganetti H and Shih HA: Clinical Application of in-room PET for in vivo Treatment Monitoring in Proton Radiotherapy. International Journal of Radiation Oncology, Biology, Physics 2013 86: 183-189

108. Grassberger C; Dowdell S; Shackleford J; Sharp GC; Choi N; Willers H and Paganetti H: Motion interplay as a function of patient parameters and spot size in spot scanning proton therapy for lung cancer. International Journal of Radiation Oncology, Biology, Physics 2013 86: 380-386

109. Paganetti H and van Luijk P: Biological considerations when comparing proton therapy with photon therapy. Seminars in Radiation Oncology 2013 23: 77-87; Top 5 most downloaded papers in Seminars in Radiation Oncology in the first half of 2013

110. Carabe A; España A; Grassberger C and Paganeti H: Clinical consequences of Relative Biological Effectiveness variations in proton radiotherapy of the prostate, brain and liver. Physics in Medicine and Biology 2013 58: 2103-2117

111. Ramos-Mendez JA; Perl J; Faddegon B; Schuemann J and Paganeti H: Geometrical splitting technique to improve the computational efficiency in Monte Carlo calculations for proton therapy. Medical Physics 2013 40: 041718

112. Zeng C; Giantsoudi D; Grassberger C; Goldberg S; Niemierko A; Paganetti H; Efstathiou JA and Trofimov A: Maximizing the biological effect of proton dose delivered with scanned beams. Medical Physics 2013 40: 051708

113. Cho J; Ibbott G; Gillin M; Gonzalez-Lepera C; Min CH, Paganetti H, Zhu X; El Fakhri G and Mawlawi O: Elemental tissue composition in proton treatment patients determined using positron emission tomography. Physics in Medicine and Biology 2013 58: 3815-3835

114. Dowdell S; Grassberger C; Sharp GC and Paganetti H: Interplay effects in proton scanning for lung: A 4D Monte Carlo study assessing the impact of tumor and beam delivery parameters. Physics in Medicine and Biology 2013 58: 4137-4156

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115. Giantsoudi D; Grassberger C; Craft D; Niemierko A; Trofimov AV and Paganetti H: Linear energy transfer (LET)-Guided Optimization in intensity modulated proton therapy (IMPT): feasibility study and clinical potential. International Journal of Radiation Oncology, Biology, Physics 2013 87: 216-222

116. Bueno M; Paganetti H; Duch MA and Schuemann J: An algorithm to assess the need for clinical Monte Carlo dose calculation for proton therapy fields. Medical Physics 2013 40: 081704

117. Cho J; Ibbott G; Gillin M; Gonzalez-Lepera C; Titt U; Paganetti H; Kerr M and Mawlawi O: Elemental tissue composition in proton treatment patients determined using positron emission tomography. Physics in Medicine and Biology 2013 58: 7497-7512

118. Grogg K; Zhu X; Min CH; Winey B; Bortfeld T; Paganetti H; Shih HA and El Fakhri G: Feasibility of using distal endpoints for In-room PET Range Verification of Proton Therapy. IEEE Transactions in Nuclear Science 2013 60: 3290-3297

119. Dowdell S; Grassberger C and Paganetti H: Four-dimensional Monte Carlo simulations demonstrating how the extent of intensity-modulation impacts motion effects in proton therapy lung treatments. Medical Physics 2013 40: 121713

120. Testa M; Verburg JM; Rose M; Min C-H; Tang S; Bentefour H; Paganetti H and Lu H-M: Proton radiography and proton computed tomography based on time-resolved dose measurements. Physics in Medicine and Biology 2013; 58 8215-8234

121. Testa M; Schümann J; Lu H-M; Shin J; Faddegon B; Perl J and Paganetti H: Experimental validation of the TOPAS Monte Carlo system for proton therapy simulations. Medical Physics 2013 40: 121719

122. Paganetti H: Advancing (proton) radiation therapy. International Journal of Radiation Oncology, Biology, Physics; 2013; 87 871-873

123. Grosse N; Fontana AO; Hug EB; Lomax A; Coray A; Paganetti H; Sartori AA and Pruschy M: Deficiency in Homologous Recombination Renders Mammalian Cells more Sensitive to Proton versus Photon Irradiation. International Journal of Radiation Oncology, Biology, Physics 2014 88: 175-181

124. Sethi RV; Giantsoudi D; Raiford M; Rappalino O; Caruso P; Yock TI; Tarbell NJ; Paganetti H and MacDonald SM: Patterns of failure following proton therapy in medulloblastoma; LET distributions and RBE associations for relapses. International Journal of Radiation Oncology, Biology, Physics 2014 88: 655-663

125. Gerweck LE; Huang P; Lu HM; Paganetti H and Zhou Y: Lifetime Increased Cancer Risk in Mice Following Exposure to Clinical Proton Beam-Generated Neutrons. International Journal of Radiation Oncology, Biology, Physics 2014 89: 161-166; Named one of the issue highlights

126. Grassberger C; Daartz J; Dowdell S; Ruggiere TA; Sharp GC and Paganetti H: Quantification of Proton Dose Calculation Accuracy in the Lung. International Journal of Radiation Oncology, Biology, Physics 2014 89: 424-430

127. Moteabbed M; Yock TI and Paganetti H: The risk of radiation-induced second cancers in the high to medium dose region: a comparison between passive and scanned proton therapy, IMRT and VMAT for pediatric patients with brain tumors. Physics in Medicine and Biology 2014 59: 2883-99; Listed as one of the highlights of 2014 in Physics in Medicine and Biology

128. Hünemohr N; Paganetti H; Greilich S; Jäkel O and Seco J: Tissue decomposition from dual energy CT data for MC based dose calculation in particle therapy. Medical Physics 2014 41: 061714

129. Paganetti H: Monte Carlo simulations will change the way we treat patients with proton beams today. British Journal of Radiology 2014 87: 0293

130. Schuemann J; Dowdell S; Grassberger C; Min CH and Paganetti H: Site-specific range uncertainties caused by dose calculation algorithms for proton therapy. Physics in Medicine and

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Biology 2014 59: 4007-4031 131. Testa M; Min CH; Verburg J; Schuemann J; Lu H-M and Paganetti H: Range verification of

passively scattered proton beams based on prompt gamma time patterns. Physics in Medicine and Biology 2014 59: 4181-4195

132. Phillips J; Gueorguiev G; Shackleford J; Grassberger C; Dowdell S; Paganetti H and Sharp G: Computing proton dose to irregularly moving targets. Physics in Medicine and Biology 2014 59: 4261-4273

133. Liebl J; Paganetti H; Zhu M and Winey BA: The influence of patient positioning uncertainties in proton radiotherapy on proton range and dose distributions. Medical Physics 2014 41: 091711

134. Frey K; Unholtz D; Bauer J; Debus J; Min CH; Bortfeld T; Paganetti H and Parodi K: Automation and uncertainty analysis of a method for in-vivo range verification in particle therapy. Physics in Medicine and Biology 2014 59: 5903-5919

135. Moteabbed M; Schuemann J and Paganetti H: Dosimetric feasibility of real-time MRI-guided proton therapy. Medical Physics 2014 41: 111713

136. Min CH; Zhu X; Grogg K; El Fakhri G; Winey B and Paganetti H: A Recommendation on How to Analyze In-Room PET for In Vivo Proton Range Verification Using a Distal PET Surface Method. Technology in Cancer Research and Treatment 2014

137. Paganetti H: Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer. Physics in Medicine and Biology 2014 59: R419-R472; Listed as one of the highlights of 2014 in Physics in Medicine and Biology

138. Min C; Paganetti H; Winey BA; Adams J; MacDonald SM; Tarbell NJ and Yock TI: Evaluation of permanent alopecia in pediatric medulloblastoma patients treated with proton radiation. Radiation Oncology 2014 9: 220

139. Lin Y; McMahon SJ; Scarpelli M; Paganetti H and Schuemann J: Comparing gold nano-particle enhanced radiotherapy with protons, megavoltage photons and kilovoltage photons: a Monte Carlo simulation. Physics in Medicine and Biology 2014 59: 7675-7689; Listed as one of the highlights of 2014 in Physics in Medicine and Biology

140. Grassberger C; Lomax A and Paganetti H: Characterizing a proton beam scanning system for Monte Carlo dose calculation in patients. Physics in Medicine and Biology 2015 60: 633-646

141. Nguyen J; Moteabbed M and Paganetti H: Assessment of uncertainties in radiation-induced cancer risk predictions at clinically relevant doses. Medical Physics 2015 42: 81-89; Editor’s Pick

142. Wouters BG; Skarsgard LD; Gerweck LE; Carabe-Fernandez A; Wong M; Durand RE; Nielson D; Bussiere MR; Wagner M; Biggs P; Paganetti H and Suit HD: Radiobiological Intercomparison of the 160 MeV and 230 MeV Proton Therapy Beams at the Harvard Cyclotron Laboratory and at Massachusetts General Hospital. Radiation Research 2015 183: 147-187

143. Giantsoudi D; Schuemann J; Jia X; Dowdell S; Jiang S and Paganetti H: Validation of a GPU-based Monte Carlo code (gPMC) for proton radiation therapy: clinical cases study. Physics in Medicine and Biology 2015 60: 2257-2270

144. Klein EE; Dong L; Paganetti H and Tanderup K: The Far-Reaching Subject Matter of Medical Physics in Radiation Oncology. International Journal of Radiation Oncology, Biology and Physics 2015 91: 697–700

145. Liu Q; Ghosh P; Magpayo N; Testa M; Tang S; Biggs P; Paganetti H; Efstathiou JA; Lu HM; Held KD and Willers H: Lung Cancer Cell Line Screen Links Fanconi Anemia Pathway Defects to Increased Relative Biological Effectiveness of Proton Radiation. International Journal of Radiation Oncology, Biology and Physics 2015 91: 1081-1089

146. Paganetti H: Relating proton treatments to photon treatments via the relative biological effectiveness (RBE) – Should we revise the current clinical practice? International Journal of

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Radiation Oncology, Biology and Physics 2015 91: 892-894 147. Polster L; Schuemann J; Rinaldi I; Burigo L; McNamara A; Stewart R; Attili A; Carlson D; Sato

T; Ramos-Mendez J; Faddegon B; Perl J and Paganetti H: Extension of TOPAS for the simulation of proton radiation effects considering molecular and cellular endpoints. Physics in Medicine and Biology 2015 60; in press

148. Ramos-Mendez J; Perl J; Schuemann J; Shin J; Paganetti H and Faddegon B: Improved efficiency in Monte Carlo simulation for passive-scattering proton therapy. Physics in Medicine and Biology 2015 60; in press

149. Grogg K; Alpert NM; Zhu X; Min C-H; Testa M; Winey B; Normandin M; Shih HA; Paganetti H; Bortfeld T and El Fakhri G: Quantitative mapping of radioactivity production rate during proton therapy. International Journal of Radiation Oncology, Biology and Physics 2015; in press

150. Grassberger C; Dowdell S; Sharp GC and Paganetti H: Motion Mitigation for Lung Cancer Patients treated with Active Scanning Proton Therapy. Medical Physics 2015; in press

Book chapters

1. Paganetti H and Bortfeld T: Proton Therapy. In: New Technologies in Radiation Oncology (Series: Medical Radiology; Subseries: Radiation Oncology); Eds. Schlegel, W.; Bortfeld, T.; Grosu, A.L.; ISBN 3-540-00321-5; Springer Verlag, Heidelberg 2005: 345-363

2. Gerweck LE and Paganetti H: Radiobiology of Charged Particles. Proton and Heavier Charged Particle Radiotherapy, (Eds. DeLaney TF and Kooy HM); Lippincott Williams & Wilkins, ISBN-13: 978-0-7817-6552-7, 2007: 8-18

3. Paganetti H: Applications to secondary radiation dosimetry in external beam radiation therapy. In: Handbook of Anatomical Models for Radiation Dosimetry (Series: Medical Physics and Biomedical Engineering); Eds. Xu, G.X. and Eckerman, K; ISBN 978-1-4200-5979-3; CRC Press / Taylor&Francis 2009: 567-590

4. Paganetti H: Dose calculations in radiation therapy based on patient models using the Geant4 Monte Carlo code. In: Handbook of Anatomical Models for Radiation Dosimetry (Series: Medical Physics and Biomedical Engineering); Eds. Xu, G.X. and Eckerman, K; ISBN 978-1-4200-5979-3; CRC Press / Taylor&Francis 2009: 607-632

5. Paganetti H; Yock T; Tarbell NJ and Trofimov A: Optimization of Treatment Delivery Technology to Minimize Radiation Injury. In: Human Radiation Injury; Eds. Shrieve DC and Loeffler L; Lippincott Williams & Wilkins, ISBN 978-1605470115 2011: 114-125

6. Paganetti H: Proton therapy: History and rationale. In: Proton Therapy Physics (Ed. Harald Paganetti); CRC Press / Taylor&Francis 2011, 1-18

7. Paganetti H: Monte Carlo simulations. In: Proton Therapy Physics (Ed. Harald Paganetti); ISBN-10: 1439836442 CRC Press / Taylor&Francis 2011, 265-304

8. Clasie B; Paganetti H and Kooy H: Dose calculation algorithms. In: Proton Therapy Physics; ISBN-10: 1439836442 CRC Press / Taylor&Francis 2011, 381-412

9. Paganetti H: Late effects from scattered and secondary radiation. In: Proton Therapy Physics (Ed. Harald Paganetti); ISBN-10: 1439836442 CRC Press / Taylor&Francis 2011, 555-592

10. Paganetti H: The physics of proton biology. In: Proton Therapy Physics (Ed. Harald Paganetti); ISBN-10: 1439836442 CRC Press / Taylor&Francis 2011, 593-626

11. Paganetti H: Protons: Clinical considerations and applications. In: Monte Carlo techniques in Radiation Therapy, (Eds. Frank Verhaegen and Joso Seco) CRC Press / Taylor&Francis 2013, 201-222

12. Das IJ and Paganetti H: History of proton beam therapy. In: Principles and Practice of Proton Beam Therapy (Eds. Indra J Das and Harald Paganetti); Medical Physics Monograph No. 37;

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Medical Physics Publishing, ISBN: 978-1-936366-43-9 2015, in press 13. Paganetti H: Relative Biological Effectiveness: RBE. In: Principles and Practice of Proton Beam

Therapy (Eds. Indra J Das and Harald Paganetti); Medical Physics Monograph No. 37; Medical Physics Publishing, ISBN: 978-1-936366-43-9 2015, in press

14. Mohan R; Zhu XR and Paganetti H: Dose calculation: Analytical. In: Principles and Practice of Proton Beam Therapy (Eds. Indra J Das and Harald Paganetti); Medical Physics Monograph No. 37; Medical Physics Publishing, ISBN: 978-1-936366-43-9 2015, in press

15. Paganetti H; Schuemann J and Mohan R: Dose calculation: Monte Carlo. In: Principles and Practice of Proton Beam Therapy (Eds. Indra J Das and Harald Paganetti); Medical Physics Monograph No. 37; Medical Physics Publishing, ISBN: 978-1-936366-43-9 2015, in press

Proceedings and other non peer-reviewed research publications

1. Becker R; Bilski P; Budzanowski M; Eyrich W; Filges D; Fritsch M; Hauffe J; Kobus H; Moosburger M; Olko P; Paganetti H; Peterson HP; Schmitz T and Stinzing F: Biophysical measurements at the COSY proton beam. Microdosimetry: An Interdisciplinary Approach, Eds. Goodhead DT; O'Neill P; Menzel HG, ISBN 0-85404-737-9, The Royal Society of Chemistry, Cambridge, UK, 1997: 266-269

2. Schmitz Th; Becker R; Bilski P; Budzanowski M; Dellert M; Drüke V; Eyrich W; Filges D; Fritsch M; Hauffe J; Kobus H; Moosburger J; Paganetti H; Peterson HP; Sperl R; and Stinzing F: Experimental biophysical investigation in a 178.9 MeV proton beam. Advances in Hadrontherapy, Eds. Amaldi U; Larsson B; Lemoigne Y, ISBN 044482782X, Elsevier Science, Excerpta Media, International Congress Series 1997, 427-433

3. Paganetti H and Schmitz Th: Do different ways of beam modulation cause different RBE values? Advances in Hadrontherapy, Eds. Amaldi U; Larsson B; Lemoigne Y, ISBN 044482782X, Elsevier Science, Excerpta Media, International Congress Series 1997, 434-439

4. Paganetti H; David P; Eickhoff W; Hänscheid H; Konijn J; Lourens W; de Laat CTAM; Risse F; Rösel Ch; Schaller L and Taal A: Der Einfluß von Meson-Austausch-Strömen beim Myoneinfang an 209Bi. Verhandlungen der Deutschen Physikalischen Gesellschaft (VI) 1991: 26, 441-442 (in german)

5. Paganetti H; Olko P; Kobus H; Waligorski MPR; Schmitz Th; Filges D and Müller-Gärtner HW: Calculation of RBE for proton beams with energies between 70 and 250 MeV using the response function model. Proceedings of the NIRS International Seminar on the Application of Heavy Ion Accelerator to Radiation Therapy of Cancer (XXI. Meeting of the Proton Therapy Cooperative Group) 1994, 192-201

6. Olko P; Waligorski MPR; Paganetti H and Schmitz Th: Biophysical Modelling of the Relative Biological Effectiveness of Therapeutical Proton Beams: Track Structure and the Response Function Approach. Proceedings of the Tenth International Congress of Radiation Research, Würzburg, Germany, Eds. Hagen U, Jung H, and Streffer C, 1995: Vol.1, 113

7. Jiang SB; Zygmanski P; Kung JH; Paganetti H; Kooy H and Chen GTY: Monte Carlo as A Tool for IMRT Verification. Proceedings of the International Workshop on Monte Carlo Treatment planning (MCTP), Palo Alto, CA, October 2000

8. Paganetti H and Goitein M: Physical and Biological Dose Distributions Due to Primary Protons and Secondary Particles From Nuclear Interactions. The Use of Computers in Radiation Therapy, Eds. Schlegel W; Bortfeld T, ISBN 3-540-67176-5, Springer Verlag, Berlin; Heidelberg; New York, 2000: 323-325

9. Kooy H; Oelfke U; Lomax T; Paganetti H; Newhauser W; Bortfeld T and Goitein M: Design Considerations for Intensity Modulated Proton Therapy Treatment Planning. The Use of

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Computers in Radiation Therapy, Eds. Schlegel W; Bortfeld T, ISBN 3-540-67176-5, Springer Verlag, Berlin; Heidelberg; New York, 2000: 71-72

10. Paganetti H: Nuclear interactions in proton therapy: Consideration in the design of the beam delivery nozzle and effect on the dose delivered to the patient and the beam's biological effectiveness. Proceedings of the 7th International Conference on Applications of Nuclear Techniques, Crete, Greece, June 2001

11. Mascia A; Schreuder N; Ilic RD and Paganetti H: Characterizing a Proton Therapy Beam with a Multi Layered Faraday Cup. Procedings of the Meeting of the American Physical Society, Maui, Hawaii, October 2001

12. Paganetti H: Monte Carlo simulations for commissioning, quality assurance, absolute dosimetry, and treatment planning at the Northeast Proton Therapy Center. The XIVth International Conference on the Use of Computers in Radiation Therapy, Eds. Byong Yong Yi, Seung Do Ahn, Eun Kyung Choi, Sung W. Ha, ISBN 89-955266-0-2 93510, Jeong Publishing, Seoul, Korea, 2004: 32-35

13. Wang B; Xu XG; Jiang H and Paganetti H: Comparison of GEANT4 and MCNPX for proton radiation treatment simulations. In: The Monte Carlo Method: Versatility Unbounded In A Dynamic Computing World, American Nuclear Society, LaGrange Park, IL: 2005

14. Jiang H; Paganetti H; Suit H; Wang B and Xu XG: A case study on patient effective doses during proton radiation treatment. In: The Monte Carlo Method: Versatility Unbounded In A Dynamic Computing World, American Nuclear Society, LaGrange Park, IL: 2005

15. Parodi K; Bortfeld TR; Paganetti H; Cascio EW; Flanz J; Bonab A; Lohmann K and Alpert NM: Experimental study on the feasibility of PET/CT imaging for 3D in-vivo treatment verification after proton radiation therapy. Proceedings of the 10th Workshop on Heavy Charged Particles in Biology and Medicine and the 4th Meeting of the European Network for Light Ion Hadron Therapy 2005, 198-201

16. Ferrari A; Lorenzo-Sentis M; Roesler S; Smirnov G; Sommerer F; Theis C; Vlachoudis V; Carboni M; Mostacci A; Pelliccioni M; Villari R; Anderson V; Elkhayari N; Empl A; Lee K; Mayes B; Pinsky L; Zapp N; Parodi K; Paganetti H; Bortfeld T; Battistoni G; Campanella M; Cerutti F; Colleoni P; Gadioli E; Garzelli MV; Lanza M; Muraro S; Pepe A; Sala P; Wilson TN; Alloni D; Ballarini F; Liotta M; Mairani A; Ottolenghi A; Scannicchio D; Trovati S; Ranft J and Fasso A: Update on the status of the FLUKA Monte Carlo transport code. Computing in High Energy Physics (CHEP), Mumbai, India, February 2006, 203

17. Zacharatou-Jarlskog C; Jiang H and Paganetti H: Proton Monte Carlo in the clinic. IEEE Nuclear Science Symposium Conference Record, 2006: 6, 3891-3893

18. Zacharatou-Jarlskog C; Lee C; Bolch W; Xu XG and Paganetti H: Methods of secondary organ equivalent dose calculation for proton therapy. XVth International Conference on the use of Computers in Radiation Therapy, Volume I, 2007, 371-375

19. Seco J; Wu Z; Sharp G; Gierga D and Paganetti H: Accounting for temporal effects in Monte Carlo simulations for lung cancer radiation therapy. XVth International Conference on the use of Computers in Radiation Therapy, Volume II, 2007, 99-103

20. Paganetti H: Treatment planning in 3 and 4 dimensions and the role of Monte Carlo techniques. IFMBE Proceedings 2007: 14, 2203-2206

21. Paganetti H; Parodi K; Adams JA and Kooy HM: Comparison of pencil-beam and Monte Carlo calculated dose distributions in proton therapy for skull-base and para-spinal tumors. IFMBE Proceedings, 2007: 14, 2219-2222

22. Seco J; Gierga DP; Sharp GC; Turcotte JC and Paganetti H: Effects of intra-fraction motion on IMRT treatments with segments of few monitor units. IFMBE Proceedings, 2007: 14, 1763-1765

23. Seco J; Jiang H; Herrup D; Kooy H and Paganetti H: A Monte Carlo tool for combined photon

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and proton treatment planning verification. Journal of Physics: Conference Series 2007: 74, 012014

24. Parodi K; Ferrari A, Sommerer T and Paganetti H: A MC tool for CT-based calculations of dose delivery and β+- activation in proton therapy. Journal of Physics: Conference Series 2007: 74, 012013

25. Heath E; Seco J; Wu Z; Sharp G; Paganetti H and Seuntjens J: A comparison of dose warping methods for 4D Monte Carlo dose calculations in lung. Journal of Physics: Conference Series 2008: 102, 012013, 1-7

26. Paganetti H: Neutron worry. Enterprise Imaging & Therapeutic Radiology Management 2008: July, 45-48

27. Attanasi F; Knopf A; Parodi K; Bortfeld T; Paganetti H; Rosso V and Del Guerra A: Clinical validation of an analytical procedure for in vivo PET range verification in proton therapy. IEEE Nuclear Science Symposium Conference Record, 2009: 9, 4167-4171

28. Grogg K; Zhu X; Min CH; Winey B; Bortfeld T; Paganetti H; Shih HA and El Fakhri G: Feasibility of using distal endpoints for In-room PET Range Verification of Proton Therapy. IEEE Transactions in Nuclear Science 2012: 3890-3894

Guidelines and Reports

1. Jones DTL; Suit HD; Akine Y; Goitein G; Goitein M; Kanematsu N; Maughan RL; Tatsuzaki H; Tsujii H; Vatnitsky SM; DeLuca PM; Gahbauer RA; Wambersie A; Whitmore GF; Andreo P; Hendry JH; Coutrakon G; Lomax A; Paganetti H and Pedroni E: Committee on prescribing and reporting dose in proton therapy. International Commission on Radiological Units and Measurements (ICRU), ICRU report 78, Journal of the ICRU 2007 7; Oxford University Press; Guidelines on the clinical use of protons

2. Ipe NE; Fehrenbacher G; Gudowska I; Paganetti H; Schippers JM; Roesler S and Uwamino Y: Shielding design and radiation safety of charged particle therapy facilites. Particle Therapy Cooperative group (PTCOG) 2010: 1-445; Report to advise proton therapy facilities on safety issues

3. Yonekura Y; Tsujii H; Hopewell JW; Ortiz Lopez P; Cosset J-M; Paganetti H; Montelius A; Schardt D; Jones B and Nakamura T: Radiological Protection in Ion beam Radiotherapy. Annals of the ICRP Vol. 43. Published for the International Commission on Radiological Protection, ICRP Publication 127

Thesis

Der Einfluß des Mesonenaustauschs bei der verzögerten Spaltung und die direkte Kernanregung von myonischem 209Bi. Rheinische-Friedrich-Wilhelms University, Bonn, Germany 1992; (Title Translation: The influence of meson-exchange currents in delayed fission and the direct nuclear excitation of muonic 209Bi)