CONTENTS OF VOLUME 21

Number 1

Obituary 1

Review W. 9. Mann

C. R. Divgi, A. M. Scott, K. McDermott, P. S. Fallone, S. Hilton, K. Siler, N. Carmichael, F. Daghighian, R. D. Finn, A. M. Cohen. J. Schlom and S. M. Larson

J. G. Tibben, L. F. A. G. Massuger, 0. C. Boerman, R. A. M. J. Claessens, G. F. Borm, K. Y. Pak, E. 9. Koenders and F. H. M. Corstens

Kathryn E. Bergmann, Scott W. Landvatter, Pamela G. Rocque, Kathryn E. Carlson, Michael J. Welch and John A. Katzenellenbogen

Aren Van Waarde, Gerben M. Visser, Ton J. Viir, Jaap Bouwer, Anne M. J. Paans and Willem Vaalburg

Christian Loc’h, Karine Mardon, Heric Valette, Catherine Brutesco, Pascal Merle& Andre Syrota and Bernard Maziere

Hide0 Saji, Yasubiko Iida, Iwao Nakatsuka, Masaki Kataoka, Takenori Miyao, Kazuhiko Ariyoshi, Yasuhiro Magata, Akira Yoshitake and Akira Yokoyama

Yasushi Arano, Hiioshi Matsushima, Masaaki Tagawa, Tatsuo fnoue, Mitsuru Koizmni, Makoto Hosono, Harmni Sakahara, Keigo Endo, Junji Konishi and Akira Yokoyama

Atsushi Takeda, Tetsu Sato and Shoji Okada

Gene-Jack Wang, Nora D. Volkow, Alfred P. Wolf, Stefan Madajewicz, Joanna S. Fowler, David J. Sehlyer and Robert R. MacGregor

Carla J. Math@ Mark A. Green, Wallace 9. Morrison and Deborah W. Knapp

Colin Tilcock, Quet Fah Abkong and Derek Fisher

Pradeep K. Garg, Sudha Garg and Michael R. Zalutsky

Ganesan Vaidyanathan, Donna AtBeck and Michael R. Zalutaky

Alan J. Fischman, Howard F. Solomon, John W. Babich, Michael J. Abrams, Ronald J. Callahan, H. William Strauss and Robert H. Rubin

3

9

17

25

41

49

57

63

71

77

83

89

97

105

111

The International Chernobyl Project Technical Report: assessment of radiological consequences and evaluation of protective measures

Clinical comparison of radiolocalization of two monoclonal anti- bodies (mAbs) against the TAG-72 antigen

Decreased kidney uptake of technetium-99m-labelled Fab’ fragments in ovarian carcinoma bearing nude mice using a cleavable chelator

Oxohexestrol derivatives labeled with fluorine-18. Synthesis, recep- tor binding and in vioo distribution of two non-steroidal estrogens as potential breast tumor imaging agents

Rodent biodistribution and metabolism of tritiated 4-DAMP, a M, subtype-selective cholinoceptor ligand

Preparation and pharmacological characterization of [76Br]-meta- bromobenzylguanidine ([76Br]MBBG)

Radioiodinated nordiazepam analog for in viuo assessment of benzodiazepine receptors by single photon emission tomography

A newly designed radioimmunoconjugate releasing a hippurate-like radiometal chelate for enhanced target/non-target radioactivity

Tumor detection by radioimaging of hepatic radiozinc-- correlation with metallothionein content

Positron emission tomography study of human prostatic adeno- carcinoma using carbon-l 1 putrescine

Evaluation of Cu-PTSM as a tracer of tumor perfusion: compari- son with labeled microspheres in spontaneous canine neoplasms

99”Tc-labeling of lipid vesicles containing the lipophilic chelator PE-DTTA: effect of tin-to-chelate ratio, chelate content and surface polymer on labeling efficiency and biodistribution behavior

Synthesis and preliminary evaluation of pam- and mefa- [ ‘*F]fluorobenzylguanidine

Monoclonal antibody F(ab’), fragment labeled with N-succin- imidyl 2,4-dimethoxy-3-halobenzoates: in uiuo comparison of iodinated and astatinated fragments

Imaging of focal sites of inflammation in Rhesus monkeys with %Tc-labeled human polyclonal IgG

111

Gerald S. Jones Jr, David R. Elmaleh, H. W. Strauss and A. J. Fischmnn

117

Technical Note Malcolm V. Phnm and Sandra J. Grihben 125

Synthesis and biodistribution of a new gvmtechnetium fatty acid

Influence of a syngeneic anti-idiotypic antibody response to a mouse anti-tumour monoclonal antibody on biodistribution of its radiolabelled Fc-intact monovalent Fab/c fragment

Book Review David M. Taylor 129

Number 2

Simona Ben-Hahn, Daniel Kahn, George J. Weiner, Mark T. Madsen, AJan D. Waxman, Cynthia M. Williams, Daniel L. Clarke-Pearson, R. Edward Coleman and Robert T. Maguire

131

Meral T. Ercan and Erkan Unlenen 143

Jean N. DaSilva, James E. Carey, Philip S. Sherman, Teresa J. Pisani and Michael R. Kllbourn

Susan Z. Lever, Kwamena E. Baidoo, Ashfaq Mahmood, Kauame Matsumura, Ursula Scheffel and Henry N. Wagner Jr

Colin Tilcock, Mel Yap, Margaret Szucs and Deepank Utkhede

Howard S. Rosenzweig, Girish N. Ranadive, Troy Seakey, Michael W. Epperly and WIIam D. Bloomer

Mohammed S. Al-T&%, Ronald M. Baldwin, Yolaoda Zen-Ponce, Elsbieta Sybirska, Sami S. Zoghbi, Marc Lamelle, Robert T. Malison, Hank F. Kuug, Robert M. Kessler, Dennis S. Chamey, Paul B. Hoffer and Robert B. Innis

Timothy R. DeCrado, G. Keith Mulholland, Donald M. Wieland and Markus Schwaiger

Reoato B. del Rosario, Yang-woon Jung, Kwameoa E. Baidoo, Susan Z. Lever and Donald M. Wieland

Paul 0. Zamora, Mark D. Domalewski, Michael J. Marek, Pin Budd and Buck A. Rhodes

Philip H. Elsinga, Aren van Waarde, Cerben M. Visser and Willem Vaalburg

Gary A. Rogers, Sharon Stone-Elander, Martin Ingvar, Lars Eriksson, Stanley M. Parsons and Lenuart Widen

J.-A. M. Tafani, B. Frances, Y. Coulais, A. M&an-Gal& M. Goeldner, C. Hirtb, R. Guiraud and J.-M. Zajac

Kazuo Kubota, Kiichi Ishiwata, Roko Kubota and Susnmu Yamada

151

157

165

171

179

189

197

205

211

219

231

239 Investigation of tumor invasion with [i’iIn]antimyosin

The safety and pharmacokinetics in adult subjects of an intravenously administered *Tc-labeled 17 amino acid peptide (CYT-379)

Accumulation of some small molecular weight complexes of *Tc in experimental abscesses

Characterization of [“C]tetrabenazine as an in vivo radioligand for the vesicular monoamine transporter

Novel technetium ligands with affinity for the muscarinic cholin- ergic receptor

PEG-coated lipid vesicles with encapsulated technetium-99m as blood pool agents for nuclear medicine

A novel method for the non-chromatographic purification of technetium-99m-labeled monoclonal antibodies: a study with B72.3 monoclonal antibody

Comparison of three high affinity SPECT radiotracers for the dopamine D, receptor

Evaluation of ( -)[i8Flfluoroethoxybenzovesamicol as a new PET tracer of cholinergic neurons of the heart

Synthesis and in vivo evaluation of a W”‘WT~-DADT- benzovesamicol: a potential marker for cholinergic neurons

Quantitation of radiolabeled antibody binding to cells by thin-layer chromatography

Synthesis and preliminary evaluation of (R,S)-I-[2-((carbamoyl-4- hydroxy)phenoxy)ethyIamino]-3-[4-(1-[”C]-methyI-4-trifluoro- methyl-2-imidazolyl)phenoxy]-2-propanol ([“C]CGP 20712A) as a selective /I,-adrenoceptor ligand for PET

‘*F-labelled vesamicol derivatives: syntheses and preliminary in vivo small animal positron emission tomography evaluation

In vivo binding of [‘251]NH,carfentanil to n opioid receptors in mouse brain

iv

Gene-Jack Wang, Prantika Som, Zvi H. Oster, Nora D. Volkow, Fum F. Knapp Jr and Donald F. Sacker

Vibhudutta Awasthi, S. Gambhir and A. B. Sewatkar

Robert Cantineau, Marcel Guillaume, Philippe Damhaut, Christian Lemaire, Alain Pleaevaux, Frangoise Gauthier, Bernard Pourrias and L&m Christiaeos

Y. Coulais, G. Cros, M. H. Darbieu, J. A. M. Tafani, H. Belhadj-Tahar, E. Bellande, R. Pasqualini and R. Guiraud

Temsbi Hamdahira, Miaom Maeda, Ayako Kato, Yoko Kaaazawa, Mayumi Yamada, Yoshikuai Torii, Yu-i&i Ichiya and Koji Masuda

Technical Notes A. K. Sin& Pusbpa Mishra, Ravi Kashyap and

U. P. S. Chauhan

DeAnna K. Coggin, Carla J. Mathias and Mark A. Green

245

251

255

263

269

211

283

Quantitative autoradiographic measurement of cocaine-induced regional myocardial metabolic changes in hypertensive rats

%Tc-insulin: labeling, biodistribution and scintiimaging in animals

Synthesis and biodistribution of [5-“‘Iliodotropapride: a potential D, dopamine receptor imaging agent

Synthesis, characterization and biodistribution of new WmTc 0x0 and nitrido complexes with bi- and tetradendate unsaturated NS and N,S, Schiff bases derived from 2-aminocyclopentene-l-dithio- carboxylic acid as potential heart imaging agents

Metabolic pathway of 2-deoxy-2-[‘*F]fluoro-D-talose in mice: trapping in tissue after phosphorylation by galactokinase

A simplified kit for instant preparation of technetium-99m human immunoglobulin-G for imaging inflammatory foci

Investigation of [67Ga]dimethyIgaIIium(III) acetylacetonate as a potential radiopharmaceutical

Number 3

EURO-IMMUNOANALYSE ‘93

Prefuce

Pierre Corvol

vii

STATE OF THE ART LECTURE

287 Information et communication cellulaires: les rtcepteurs couplCs aux proteines G

LECTURES

M. Gounnelen, L. Perin and Y. Le ROUC

HenrI Pujol

297 IGFs and their binding proteins

303 Inttrit d’une ditection pr6coce des mktastases? Impact sur Ia survie et Ia qualit de vie

SESSION 1: HETEROGENEITY OF CIRCULATING HORMONES

Anne-Marie Nagy, Sylvain Meurls and Claude Robyo

317

Bmao Claustrat, Joeelyne Brun, Jacques Champier, Catherine Harthe and Marie-OdUe Joly

331

R. Rizzoli, L. Vadas and J-W. Ronjour 331

M. Roger and N. Lalhou 349

J. M. Guliana, J. Taboulet, C. Calmettes, 359 G. Milhaud, M. S. Moukhtar and A. JuUienne

Origin and significance of the heterogeneity of protein hormones

Heterogeneity of human prolactin. Influence on immunoassays (RIA and IRMA)

Determination of circulating parathyroid hormone levels and differential diagnosis of hypercalcemia

Heterogeneity of plasma gonadotropins. Consequences on im- munological properties of LH

Heterogeneity of circulating calcitonin levels: relations with calci- tonin biosynthesis in medullary thyroid carcinomas

V

Gerbard Baumanu, Melissa Sbaw, 369 Heterogeneity of circulating growth hormone Klauss Amburn, Tauhid Jan, Norma Davila, Moises Mercado, Mark Stolar and John MacCart

Jiirg Chard 381 Apparent growth hormone levels in plasma and urine. Methodo- logical “artefacts”

G. Sassolas, R. Cohen and J. J. Tsati 393 Strategic d’exploration des &tats d’hyper&retion d’hormone de croissance

Jean-Claude Job and Pierre Cbatelain 401 Present and potential uses of growth hormone in therapeutics

SESSION 3: BIOLOGICAL DIAGNOSIS OF BLOOD TRANSMITTED VIRAL INFECTION

Paul V. Holland 407 Overview: Diagnostic tests for viral infections transmitted by blood

C. Trepo, C. Alonso, J. S. Li, D. Qu, F. Laurent 419 Limites du diagnostic immunoserologique et moleculaire de and L. Vitvitski l’hepatite C

J. M. Lemaire, S. Voisin and J. Coste 433 Serological diagnosis of HTLV-I/II infections in France

Elisabetta Cariani, Antonella Ravaggi, 441 Diagnosis of viral hepatitis with a nonisotopic hybridization assay AntoneRa Zonaro, Albert0 Albertini and Daniele Primi

SESSION 4: THE BIOLOGY OF CANCER

Richard J. Auchus and Suzanne A. W. Fuqua 449 Prognostic factors and variant estrogen receptor RNAs in clinical breast cancer

P. Teillac 455 Que peut attendre aujourd’hui le clinicien du dosage du PSA?

J. Grenier, J. L. Pujol, F. Guilleux, J. P. Daures, 471 Cyfra 21-1, a new marker of lung cancer H. Pujol and F. B. Micbel

C. Bohuon, J. M. Bidart, P. Ghilhmi-Dalbin, F. Troalen and D. BeRet

477 Problemes analytiques dans le dosage de marqueures tumoraux

Richard Cohen, Ciao-Carlo ZuccheRi, Marc Fraysse, Alessandro Pilo, MarieYolande Rigault, Serge Griilet and Charles-Albert BizoRon

483 ‘Oncocheck’: an international external quality assessment scheme for immunoassays of tumor markers

SESSION 5: CURRENT EVENTS IN IMMUNOANALYSIS

Roger Ekins 495 Immunoassay: recent developments and future directions

P. Fraucbhnont, A. Hazout, Y. Menezo 523 Insulin-like Growth Factors 1 et II dans la maturation folliculaire and J. Colette et ovocytaire

Luigi Bartalena, Paolo Vitti and Aldo pin&era 531 Diagnosis of thyroid dysfunction: present and future

Jacques Pirenne, France Pirenne-Noizat, 545 Cytokines and organ transplantation. A review Donat de Groote, Yvonne Vrindta, Miguel Lopez, Ret& Cathy, Nicolas Jacquet, Michel Meuriase, Pierre Honore and Paul Franchimont

Gianfranco Giraudi and Claudio Baggiani 557 Immunochemical methods for environmental monitoring

vi

Number 4

Farah Shah, Susan P. Hume, Victor W. Pike, Sharon Ashworth and Joe McDermott

Eva Barbarics, James F. Kronange, Catherine E. Costello, Gy. A. Janoki, B. Leonard Hobnan, Alan Davison and Alnn G. Jones

Raymond E. Gibson, Holly T. Beauchamp, Christine Fioravanti, Nancy Brenner and H. Donald Burns

D. Scott Wilbur, Donald K. Hamhn, John C. Livesey, Rajiv R. Srivastava, George E. Laramore and Thomas W. Griffin

Konichi Wada, Yasuhisa Fnjibayasbi, Hideynki Tanhrchi, Naoyuki Tajima, Nagara Tamaki, Junji Konishi and Akira Yokoyama

Sally W. Schwarz, Judith M. Connett, Carolyn J. Anderson, Pamela A. Rocque, Gordon W. Philpott, Li Wu Gno and Michael J. Welch

Christer Halldin, Thomas Hiigberg and Lars Farde

Jean Meng, David R. Elmaleh, Shireen Jyawook, Stephen Weiss, Nathaniel M. Alpert, John W. Babich, Ronald G. Tompkins and Alan J. Fischman

Ravi S. Harapanhalli, Roger W. Howell and Dandamudi V. Rao

Gary L. Griffiths, David M. Goldenberg, Anastasia L. Jones and Hans J. Hansen

649

N. C. Goomer, P. V. Kulkarni, A. Constantinescn, P. Antich, R. W. Parkey and J. R. Corbett

651

0. T. DeJesns, D. Murali, R. Kitchen, C. Endres, T. R. Oakes, S. E. Shelton, L. Freund, D. Houser, H. Uno, J. E. Holden and R. J. Nickles

663

E. Livni, Whrston Satterlee, Roger L. Robey, Charles A. Ah, Elden E. Van Meter, John W. Babich, Wiiam J. Wheeler, Douglas D. O’Bammn, James H. ThraU and Alan J. Fischman

669

Technical Note Samuel M. Mazza and Terry Yoshizmnl 611

Announcement

513

583

593

601

613

619

621

633

641

I

Synthesis of the enantiomers of [N-methyl-“C]PK 11195 and comparison of their behaviours as radioligands for PK binding sites in rats

In oiuo metabolism of the technetium isonitrile complex [Tc(2- ethoxy-2-methyl-1-isocyanopropane),l+

Receptor binding radiotracers for the radioiodinated [Sar’, Ile’]angiotensin II

Synthesis and radioiodination of a nido of 2-nitroimidazole

angiotensin II receptor:

1,2-carboranyl derivative

Effects of ischemia-reperfusion injury on myocardial single pass extraction and retention of Cu-PTSM in perfused rat hearts: comparison with “‘Tl and “C-iodoantipyrine

Evaluation of a direct method for technetium labeling intact and F(ab’), lA3, an anticolorectal monoclonal antibody

Fluorine-18labelled NCQ 115, a selective dopamine D-2 receptor ligand. Preparation and positron emission tomography

Synthesis of 2-[‘*F]fluoro-2-deoxy-~-glucose and positron emission tomography studies in monkeys

bis-Benzimidazole dyes, Hoechst 33258 and Hoechst 33342: radioiodination, facile purification and subcellular distribution

Preparation of a pure 99mTc-F(ab’), radioimmunoconjugate by direct labeling methods

Synthesis and evaluation of a new class of technetium-99m mono- cationic radiotracers from dithienyldiazalkanes

Evaluation of 3-[‘sF]fluoro-a-fluoromethyl-p-tyrosine as a tracer for striatal tyrosine hydroxylase activity

Synthesis of [“Cldapoxetine. HCl, a serotonin re-uptake inhibitor: biodistribution in rat and preliminary PET imaging in the monkey

48V radionuclidic impurity in product streams from liquid cyclotron targets with titanium windows

Number 5

DIAGNOSTIC IMAGING IN ONCOLOGY

W. C. Eckebnan, G. Di Chiro, M. Salvatore and S. M. Larson

681 Introduction

vii

STRUCTURAL IMAGING

Charles L. Dumoulin 683 Magnetic resonance angiography: today and tomorrow

Willi A. Kalender 693 Principles and applications of spiral CT

Giovanni Siiouetti, Antonio Orlacchio, 701 Advances in interventional radiology in oncology Ezio Faoucci and Raimoudo Chiusauo

Viuceuzo CavaUo and Fraucesco Giovagnorio

Giuseppe Beffiore, Sabato di Filippo, Cesare Guida, Ines Marauo and Ernest0 Porta

709 HRCT studies of lung anatomy

713 CT-guided biopsy of lung lesions

FUNCTIONAL IMAGING

Steven M. Larson, Chaitanya Divgi, Andrew Scott, Farhad Daghighiau, Homer Macapinlac and Sydney Welt

Homer A. Macapinlac, Audrew M. Scott, Steven M. Larson, Chaitanya R. Divgi, Samuel D. J. Yeh and Stanley J. Goldsmith

Randall A. Hawkins and Carl K. Hoh

Michael V. Kuopp, H. Biscboff, W. J. Lorenz and G. Van Kaick

William C. Eckelman

Silvana Del Vecchio, M. Patrizia Stoppelli, Maria V. Carriero, Roan Fonti, OrueIla Maasa, Pei Yong Li, Gerard0 Botti, Maria Cerra, Giuseppe D’Aiuto, Giuseppe Esposito and Marco Salvatore

A. M. Scott, H. Macapinlac, J. J. Zhang, H. Kalaigian, M. C. Graham, C. R. Divgi, G. Sgouros, S. J. Goldsmitk and S. M. Larson

Steven M. Larson, Chaitanya R. Divgi, Andrew Scott, George Sgouro5, Martin C. Graham, Lale Kostakoglu, David Scheinberg, Nai-Kong V. Cheung, Jeffrey Schlom and Ronald D. Finn

Michinao Miigaki, Takanori Hishinuma, Katsubiko Kimura, Hitoshi Nakamura, Hisashi Aso, Fumio I&ii, Masazumi Nishikawa, Kunibiko Itoh, Yoshihisa Tomioka, Shunji Ishiwata, Hi& Moritani, Taizo Uyama and Tatsuo Ido

793 The distribution of [“Clcocaine in normal and cocaine-sensitization mice

Toshiaki Irie, Kiyoshi Fukushi, Yosbio Akimoto, 801 Design and evaluation of radioactive acetylcholine analogs for Hiroshi Tamagami and Tadashi Nozaki mapping brain acetylcholinesterase (AchE) in vivo

Fund Nagatsugi, Shigeki Sasaki and Miuoru Maeda

809 8-[‘*F]Fluorooctanoic acid and its /?-substituted derivatives as potential agents for cerebral fatty acid studies: synthesis and biodistribution

Stefan Gublke, Haus-Jiirgen We&r, Christian Bruns and Gerhard St&&En

721 Current status of radioimmunodetection

731 Gallium-674trate imaging in nuclear oncology

739

749

159

771

775

785 Current status of radioimmunotherapy

PET FDG studies in oncology

PET imaging of lung tumours and mediastinal lymphoma

The application of receptor theory to receptor-binding and enzyme- binding oncologic radiopharmaceuticals

In vitro receptor imaging for characterization of human solid tumors

Clinical applications of fusion imaging in oncology

Number 6

819 (2-[‘*F]fluoropropionyl-(D)phe’)-octreotide, a potential radio- pharmaceutical for quantitative somatostatin receptor imaging with PET: synthesis, radiolabeling, in vitro validation and bio- distribution in mice

VIII

Uwe Habetkorn, SibyUe I. Ziegler, Franz Obetdotfet, Hetbett Trojan, Diet&b Haag, Peter Peschke, Mattin R. Betget, Annette Altmann and Getbatd van Kaick

Uwe Habetkom, Franz Obetdorfet, Thomas Klennet, Ludwig G. Strauss, Michael St&t, Reinhatd Wallich, Annette Altmann and Getbatd van Kaick

Stephen M. Moetlein, Joel S. Petlmuttet, Michael J. Welch and Marcus E. Raichle

Allen R. Btaun, Richatd E. Carson, H. Richard Adams, Ronald D. Finn, Barbara E. Francis and Peter Herscovitch

Moustapha Hassan, Assam Refai, Mats Andetsson, Pet-Olof Scbnell and Hans Jacobsson

Zhenping Zhu, Tarunendu Chose, Yatoslav Ktalovec and Chunzheng Yang

A. Ciatmiello, L. Pace, S. Betocchi, B. Alfano, M. Chiatiello and M. Salvatote

Technical Notes Malcolm V. Pimm and Sandra J. Gribben

Mikl6s Pap&s, Je& Llng, Mitia Rajtht and L&z16 Csetnay

David A. Goodwin, Charles McK. Ransone, Carol I. Diamanti and Maureen McTigue

Letter to the Editors Kouichi Wada, Yasuhisa Fujibayashi,

Naoyuki Tajima and Akita Yokoyama

M. B. Awang, J. G. Hardy, S. S. Davis, M. V. Pimm, S. J. Patty and I. R. Wilding

Rodney L. Page, Pradeep K. Gatg, Ganesan Vaidyanathan and Michael R. Zalutsky

D. Bender, M. Holschbach and 6. Stiicklin

Pet Hattvig, Johann Vdtysson, Gunnar Antoni, G&tan Westetbetg, Bengt L8ngstr6m, Enrica Ratti Moberg and Ivat 0ye

Jae Min Jeong, Seigo Kinuya, Chang H. Paik, Tsuneo Saga, Vitendar K. Sood, Jorge A. Carrasquillo, Ronald D. Neumann and James C. Reynolds

A. Vethagen, M. Studeny, G. Luurtsema, G. M. Visset, C. C. J. De Goeij, M. Sluyset, 0. E. Nieweg, E. Van Det Ploeg, K. G. Go and W. Vaalburg

827

835

847

857

865

873

883

889

893

897

901

905

911

921

921

935

941

FDG uptake, tumor proliferation and expression of glycolysis associated genes in animal tumor models

Metabolic and transcriptional changes in osteosarcoma cells treated with chemotherapeutic drugs

First-pass extraction fraction of iodine-123 labeled perfusion tracers in living primate brain

A kinetic comparison of [‘*F]2-fluoro-2-deoxyglucose and [‘8FJ2- fluoro-2-deoxymannose using positron emission tomography

In uiuo dynamical distribution of “‘I-VIP in the rat studied by gamma-camera

Immunoreactivity, stability, pharmacokinetics and biodistribution of a monoclonal antibody to human leukemic B cells after three different methods of radioiodination

Assessment of left ventricular regional function by radionuclide angiography: effects of number of sectors on repeatability

Effect of systemic DTPA treatment on tissue retention of free and carrier-bound “‘In from labelled proteins and polymer

Leukocyte labeling with 99”Tc-HMPA0. The role of the in t’rtro stability of HMPAO on the labeling efficacy and image quality

Rapid synthesis and quality control of 68Ga-labeled chelates for clinical use

A new radioiodinated agent for detecting radicals in uioo: synthesis and preliminary evaluation

Evaluation of ‘53Sm-diethylenetriaminepentaacetic acid for radio- labelling of pharmaceutical dosage forms by neutron activation

Preclinical evaluation and PET imaging of ‘*F-labeled Mel-14 F(ab’), fragment in normal dogs

Synthesis of n.c.a. carbon-11 labelled clozapine and its major metabolite clozapine-N-oxide and comparison of their biodistri- bution in mice

Brain kinetics of (R)- and (S)-[N-methyl-“Clketamine in the Rhesus monkey studied by positron emission tomography (PET)

Application of high affinity binding concept to radiolabel avidin with Tc-99m labeled biotin and the effect of pI on biodistribution

Metabolism of a [“F]fluorine labeled progestin (21-[‘8F]fluoro- 16u-ethyl-19-norprogesterone) in humans: a clue for future investigations

ix

Mitsuhiko Akabushi, Keniehi Kawai, Yoshiko Tanaka, Teruie Smnino, Shinichiro Masunaga, Koji Ono and Tokiharu Miyahara

953

Hiroyuki Nakamichi, Matsutaro Murakami, Shuicbi Miura, Yasushi Kondoh, Shigenori Mizusawa and Yukihiko Ono

959

P. Bassa, J. R. Garcia Car&, C. Piers, 963 A. Pavia, M. Minoves, M. Moragas, J. Pavia, F. Lomefia and J. Setoain

Ronald M. Baldwin, Yolanda Zea-Ponce, 969 Sami S. Zoghbi, Mohammed S. Al-Tikriti, John P. Seibvl. Elzbieta H. Svbirska. Robert T. M&son, Marc La&eUe, Dennis S. Chamey, Paul B. Hoffer and Robert B. Innis

Pharmacokinetics of the three radioiodinated dopamine D, recep- tor ligands [lz31]IBF, [1231]epidepride and [1231]2’-ISP in nonhuman primates

R. E. Shefer, B. J. Hughey, R. E. Klinkowstein, 977 A windowless 13N production target for use with low energy M. J. Welch and C. S. Dence deuteron accelerators

C. S. Dence, M. J. Welch, B. J. Hughey, R. E. Shefer and R. E. Klinkowstein

987

M. R. A. PiBai, E. 0. Schlemper and W. A. Volkert

997

L. W. Herman, A. J. Fischman, R. G. Tompkins, 1005 R. N. Hanson, C. Byon, H. W. Strauss and D. R. Ehnaleh

Technical Notes Joseph C. Hung and Thomas J. Herold 1011

Guillermina Ferro-Flares and Judith Lezama-Carrasco

1013

Jakobina Gr&arsd&tir, Eva Forssell Aronsson, 1017 Lars Jacobsson, 6liif Hafsteinsdbttir, Stig Hoimberg, Larsolof Hafstriim, Sture Lindegren, B&je Karlsson, Leif Liadholm and Siiren Mattsson

F. Nicholas Franano, W. Barry Edwards, Michael J. Welch and James R. Duncan

1023

D. J. Hnatowich, F. Virzi, M. Fogarasi, M. Rusekowskl and P. Whmard Jr

1035

Peter S. Conti, John Hilton, Dean F. Wong, Mian M. Alauddin, Robert F. Danoak+, Hayden T. Ravert, Alan A. Wilson and James H. Anderson

1045

Tor Kihlberg, Sven VaIiod and Bengt LllngstGm

1053

Tor Kihlberg, Sven Valind and Bengt L&striim

1067

Wolfgang Brandau, Sabine Fischer, Comelia Pusksis, Axe1 Steinstriiger, Ludwig Kuhknann and Otmar Sebober

1073

Determination of the target volume of HeLa cells treated with platinum-195 m radiolabeled cis-diammine( l,l-cyclobutane- dicarboxylato)platinum(II); comparison with cis- and trans- diammine-dichloroplatinums(I1)

Does the anabolic metabolism of L-[2-‘8Flfluorophenylalanine and L-[2,6-3H]phenylalanine differ in the cerebrum and the cerebellum?

Procedure for red blood cell labelling with 99mTc-HMPA0. Methodology and quality control

Production of [‘3N]ammonia applicable to low energy accelerators

Some observations on the instability of 99”Tc-complexes of propylene amine oxime (PnAO)

The use of pentafluorophenyl derivatives for the ‘*F labelling of proteins

Modified radioiodination and quality control methods for [‘251]sodium iothalamate

A freeze dried kit formulation for the preparation of 99mTc-EHDP-MoAb-IOR CEAl complex

Number 8

‘251-lab-elling of an internally 75Se-labelled monoclonal antibody- biodistribution in tumour-bearing nude mice

Metabolism of receptor targeted “‘In-DTPA-glycoproteins: identification of “‘In-DTFA+-lysine as the primary metabolic and excretory product

Can a cysteine challenge assay predict the in oiuo behavior of *Tc-labeled antibodies?

High performance liquid chromatography of carbon-11 labeled thymidine and its major catabolites for clinical PET studies

Synthesis of fatty acids specifically labelled with “C in various positions, including 2H substitution, for in viuo studies of myocar- dium using PET

Synthesis of [I-“Cl, [2-“Cl, [l-“C](2H3) and [2-“C](H,)acetate for in viuo studies of myocardium using PET

New renal function imaging agents. I. Synthesis and biological characterization of a pTc]diaminomercapto(thio)ether (DAMTE)

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Makiko Suehiro, Ursula A. Scheffel, Hayden T. Ravert, George A. Ricaurte, George Hatzidimitriou, Robert F. Dam&, Klaus P. Bagese and Henry N. Wagner Jr

Fabrice Perin, Didier Holfschir, Jean-Christophe Pittet, Franqois Daburon, Ghrd Normier, Hans Binz and Alain Le Pape

L. M. Guerdoud, R. Ouellet and J. E. Van Lier

Alfred F. McFee, Scott D. Robertson, and Lee C. Washburn

Prahlad R. Sigh, Kavita K. Katti, Kattesh V. Katti, Mel Corlija, Alan R. Ketring, Wynn A. Volkert and Richard R. Hoboes

1083 Highly potent indanamine serotonin uptake blockers as radio- tracers for imaging serotonin uptake sites

1093 Evaluation of possible interference of anti-inflammatory drugs upon scintigraphic imaging with macrophage targeting 99”Tc-J001X: effects of methylprednisolone, dexamethasone, in- domethacin and methotrexate

1101 Evaluation of 99mTc-labeled modified serum albumin for tumor detection

1109 Cytogenetic damage in marrow cells of mice after injections 01 yttrium-904abeIed monoclonal antibody

1115 A new WmTc-complex with a germanium-hydrazide (GeTH) ligand

Book Review David M. Taylor 1119