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CHMI 2227 - E.R. Gauthier, Ph.D. 1
CHMI 2227EBiochemistry I
Proteins:-Levels of Protein Structure-Conformation of Peptide Group
CHMI 2227 - E.R. Gauthier, Ph.D. 2
Proteins: Levels of Protein Structure
http://macromolecules.ucsf.edu/Lectures/Tanja%20Macromol_forces%202006.pdf
CHMI 2227 - E.R. Gauthier, Ph.D. 3
Primary Structure
http://www.fiu.edu/~bch3033/Handouts/Lh4Ch04Prot.pdf
CHMI 2227 - E.R. Gauthier, Ph.D. 4
Secondary Structure
http://www.fiu.edu/~bch3033/Handouts/Lh4Ch04Prot.pdf
CHMI 2227 - E.R. Gauthier, Ph.D. 5
Tertiary Structure
http://www.fiu.edu/~bch3033/Handouts/Lh4Ch04Prot.pdf
CHMI 2227 - E.R. Gauthier, Ph.D. 6
Quaternary Structure
http://www.fiu.edu/~bch3033/Handouts/Lh4Ch04Prot.pdf
CHMI 2227 - E.R. Gauthier, Ph.D. 7
Proteins
CHMI 2227 - E.R. Gauthier, Ph.D. 8
CHMI 2227 - E.R. Gauthier, Ph.D. 9
Secondary Structure of Proteins
http://employees.csbsju.edu/hjakubowski/classes/ch331/protstructure/olunderstandconfo.html
CHMI 2227 - E.R. Gauthier, Ph.D. 10
Conformation of the Peptide Group
Peptide Group
CHMI 2227 - E.R. Gauthier, Ph.D. 11
Peptide bond has resonance structures!
Peptide bond is shown as single C-N bond
Peptide bond is shown as a double bond
CHMI 2227 - E.R. Gauthier, Ph.D. 12
Conformation of the peptide group
Figure 3.25 Biochemistry 2001, Fifth Edition
CHMI 2227 - E.R. Gauthier, Ph.D. 13
Cis conformation of the peptide group
R2R1
Cα CαC N
O H
CHMI 2227 - E.R. Gauthier, Ph.D. 14
Trans conformation of the peptide group
Cα
Cα
R1
R2
N
H
C
O
CHMI 2227 - E.R. Gauthier, Ph.D. 15
Exceptions to the rule!
Figure 3.26 Biochemistry 2001, Fifth Edition
CHMI 2227 - E.R. Gauthier, Ph.D. 16
Psi and Phi Angles
CHMI 2227 - E.R. Gauthier, Ph.D. 17
Psi and Phi Angles
Peptide Bond
CHMI 2227 - E.R. Gauthier, Ph.D. 18
Psi and Phi Angles
CHMI 2227 - E.R. Gauthier, Ph.D. 19
Animation of Phi rotation
Phi rotationhttp://employees.csbsju.edu/hjakubowski/classes/ch331/protstructure/olunderstandconfo.html
CHMI 2227 - E.R. Gauthier, Ph.D. 20
Animation of Psi rotation
Psi rotationhttp://employees.csbsju.edu/hjakubowski/classes/ch331/protstructure/olunderstandconfo.html
CHMI 2227 - E.R. Gauthier, Ph.D. 21
Ramachandran Plot
CHMI 2227 - E.R. Gauthier, Ph.D. 22
Ramachandran Plot
Figure 3.28 Biochemistry 2001, Fifth Edition
