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Chapter 3. Cell structure Cell membrane Endocytosis and Exocytosis Cytoplasm Cell Organelles:- Lysosom, Mitochondria, Endoplasmic reticulum, Golgi Apparatus, cell Nucleus DNA, RNA Protein Synthesis and Secretion. THE CELL. Nucleus. Endoplasmic Reticulum. Cytoplasm. Lysosomes. - PowerPoint PPT Presentation
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Chapter 3• Cell structure
• Cell membrane
• Endocytosis and Exocytosis
• Cytoplasm
• Cell Organelles:- Lysosom, Mitochondria, Endoplasmic reticulum, Golgi Apparatus, cell Nucleus
• DNA, RNA
• Protein Synthesis and Secretion
THE CELL
Cell membrane
Nucleus
Cytoplasm
Endoplasmic Reticulum
Mitochondria
Lysosomes GolgiApparatus
Cell and its Composition• Normally cells are composed of:
1- Water = 70-80%
2- Proteins = 10-20%
3. Lipids = 2%
4. Carbohydrates = 1%
5. Various ions = small quantities (K+, Mg++, Phosphate Sulphate, Bicarbonate, Na+, Cl-, Ca++)
The Cell• There are many different types of cells in the body. Cells differ according to
their structure and function.
• A cell can be divided into 3 principal parts:
1- Cell membrane: permeable membrane surrounding the cell. It separates intracellular from extracellular environment.
2- Cytoplasm and Organelles: Cytoplasm is fluid-jelly like content of the cell in which the organelles float.
3- Nucleus: spheric body in the cell which contains genetic material. It is the commanding center of the cell.
Cell MembraneCell membrane forms a barrier between intracellular fluid (ICF) and extracellular fluid (ECF). It is composed of phospholipids, proteins and carbohydrates.
Extracellular
Intracellular
Cell Membrane
= is thin, only two molecules thick and
continuous over the entire cell surface.
- Behaves like fluid, therefore the floating membrane proteins can move around all areas of the cell membrane.
- The lipid bilayer is almost impermeable to water and water soluble substances (glucose, urea, various ions).
- The lipid bilayer is permeable to fat-soluble substances (O2, CO2, and alchohols).
Phospholipids bilayer
Cell Membrane
= are mostly glycoproteins (proteins+carbohydrates).
- Two types of membrane proteins:
i) integral proteins: protrude all the way through the cell. These proteins provide pathways through which water and water-soluble substances can cross.
ii) peripheral proteins: occur on the membrane, and normally attached to the integral proteins. These proteins function as enzymes to control the chemical reactions inside the cell.
Peripheral protein
Integral protein
Proteins
Cell Membrane= are usually on the outside of the membrane
attached to the protein molecules. These carbohydrates which are usually attached to proteins making glycoproteins play an important role in immune reactions and also act as receptors on the surface of the cell.
Carbohydrates
Carbohydrates + Proteins =Glycoproteins
Carbohydrates + Lipids =Glycolipids
- Ions, molecules and water can cross cell membrane by various methods
which will be explained in future lectures. Large molecules (proteins and cell debris) have other means of exchange between ICF and ECF:
- 1- Endocytosis = formation of an invagination by the cell membrane to engulf extracellular fluid and other materials. (phagocytosis, pinocytosis, and receptor-mediated endocytosis)
2- Exocytosis = is the reverse of endocytosis. Is used for secretion of materials by the cell.
Cell Invagination Engulfing and fussionof the membrane
Completeengulfing
Nucleus
Endocytosis and Exocytosis
Cytoplasm
- Jellylike matrix within the cell is known as cytoplasm.
- is not homogenous solution, but is highly organized structure of microtubules and microfilaments.
Lysosomes- Membrane-bound organelles which contain digestive enzymes. The vacuole
which contains the products of phagocytosis may fuse to a lysosome. The digestive enzymes breakdown the large molecules into smaller molecules.
- Lysosomes: - fuse with food vacuole, - fuse with vacuoles containing bacterial debris, - engulf worn-out organelles, - rupture to initiate cell death
Mitochondria
- Serve as the site for energy
production- cell powerhouse.- Able to migrate throughout
the cytoplasm
- It is believed that they are
able to reproduce. They have
DNA (primitive).
ENERGY PRODUCTION
Endoplasmic Reticulum
- There are two types:
1- Rough Endoplasmic Reticulum (RER)= contains ribosomes on its surface. It is involved in protein synthesis, present in glandular cells.
2- Smooth Endoplasmic Reticulum (SER) = has no ribosomes on its surface. Is an storage area and were some cellular reactions occur, present in skeletal muscle for Ca++ storage.
RER SER
Golgi Apparatus- Proteins which are synthesized in RER are transported and stored in the
Golgi apparatus. Golgi apparatus functions:
1- Separation of different proteins according to their functions.
2- Modification of proteins
3- Package of proteins for delivery
to different parts.
Cell Nucleus- Most cells have a single nucleus while some like skeletal muscle are multinucleated.
- Nuclear envelope: inner and outer membranes which surround the nucleus.
- transport in and out of the nucleus?
- Functions of DNA, RNA and mRNA?
Nuclear Pores
Protein SynthesisGenetic information is contained in DNA.
-To convert genetic code
(DNA code) to protein:
DNA code is first
transcribed into RNA
(genetic transcription).
Genetic Transcription occurs in NUCLEUS
Protein SynthesisThe RNA (mRNA) which has been copied DNA code goes to cytoplasm at the
ribosomes and starts the synthesis of proteins according to the transcribed code.
mRNA
Nucleus
Cytoplasm