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:

E

E A ( C) E D D

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?

?

?

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& C

A A C

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Post vaccination Neutralising antibodies

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Macrophageactivation

Ag

APC

T HB T C

Antibodyproduction Cytotoxicity

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Lymphocyte in peripheral blood

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CD3 CD4 CD8

CD19 B

CD16 & CD56

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C CE E EC ED

D

D

E A E E EC ED

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C

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A 2

A

E

A E

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E

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Exogenous pathway.APCs take up extracellular antigenCleave into peptides

Load peptides into HLA class II molecules

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HLA Peptide TCR complex

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C

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A C

C C

C

A

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APC

MHC

peptide

TCRT cell

CD4

CD3

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APC

MHC

TCRT cell

CD28

CD40

CD40ligand

b7

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APC

MHC

TCRT cell

ICAM1/LFA-1

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A

Signal 1

Signal 2

Activation

DangerSignal &Signal 3

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B A

C A

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Granuloma FormationTh1 cells & MacrophagesRequires IFN, TNF

Ag

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Macrophageactivation

Ag

APC

T HB T C

Antibodyproduction Cytotoxicity

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Cytotoxic T cells Serial killers!!

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!!

? ?

? ? ?