Brief Title: Ublituximab for Acute Neuromyelitis Optica ...€¦ · Brief Title: Ublituximab for Acute Neuromyelitis Optica (NMO) Relapses Document Date: August 3, 2017 Document:

Brief Title: Ublituximab for Acute Neuromyelitis Optica (NMO) Relapses Document Date: August 3, 2017 Document: Protocol and Statistical Plan ClinicalTrials.gov ID: NCT02276963

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•� nlsb l X msl u C8 ( Xs l X msl u l; (s u D•� Xox b xl;sXL•� XauaUL 6 6 C (( m lw D•� Xox (X Um m L s ;s0 s ; X mlmU m s sb m a sX sx ms)•� l XlmaU m u k u•� uu aoms L ulxls uan Lsax sXL ( m u

CGRKUF CR OR GRG

•� a sb s X C X lm6 Xkl u ;(lm 6 sbaX l ;(lm D nlsb m nlsbaosU aulmlox amsX ;s)

NGBCT TBF C

uu ;o i s; nluu X lk W L; a lmsX k mao; 9®®® xU x sbLu(X ml;auamCX XX sa U m Xl uuL ; p;s Xal ;eD ; ( X sb oXX ms ;s m X a X )

o i s; nluu uu X lk +W® xUf L a lmo; ak X aoX baoX; ; ua; sa sbam; s a ;s Xal sX sx ms ; (a;;l u 6 oXlmU sb s Xal X sx ms b ; )b X aX uu ;o i s; nluu X lk H ;s Xal ;)

uu ;o i s; nluu X lk (X cx l slam (XlaX sa lmo;lam a )

K F B RBNCi((Xawlx s uL 8® xlmos ; (XlaX sa sb lmo;lam a +W® xUf L a 6 ;o i s; nluu(X cx l s nlsb m mslbl;s xlm C l(b mbL X xlm %W xU aX Tolk u msD)

; a aX u s xlma(b m EW® xU CaX Tolk u msD nluu uuan aX ;o i s; nbaw( Xl m k X aX (LX wl 6 aX ; ulml uuL n XX ms )

C OUGBNC C3 OUGBNCKBR KB

o i s; ulUl u aX mXauux ms xo;s x s uu a sb auuanlmU Xls Xl 39)� u m nluulmU sa (Xakl nXlss m lmaXx am; ms)%)� 9Ic9®® L X; a U )8)� n os a(sl m oXlsl; m faX sX m;k X; xL ulsl;) m n ulml u k ms l;

lm ; ulml uuL ;lUmll ms m oXauaUl l lsC;D am (bL;l u w x6 masssXl os u sa masb X l; ; (Xa ;;6 nbl b l; l X ms Xax ; ulmm oXauaUl u w x6 m ssXl os u sa u ;lam lm sb ;(lm u aX 6 a(slm Xk aX X lm;s x) n ;Lx(sax; xo;s X (aXs nlsblm 9® L; aam; s)

+)� amlXx aX blUbuL ;o;( s l Uma;l; a aX lmU sa sb %®®EX kl;lam; a sb lmU X bot l Uma;sl Xls Xl aX C lmU X bot6%®®ED6 aX + (a;lslk ( X sb ol ulm ;) aX 6;o i s; xo;s b k sna ;auos Xls Xl 3

)� a(sl m oXlsl;)� xL ulsl;

C s u ;s sna a sbX ;o((aXslk Xls Xl 3)� (X ; m a amslUoao; ;(lm u aX u ;lam ws m lmU ak X sbX

aX xaX k Xs X u ; Ux ms;6)� Xls Xl ; sl;LlmU sb X kl; am u l Uma;sl Xls Xl

aX 2 aux m6 %®99.)� c U C +D lm ; Xox)

aX 6 ;o i s; xo;s b k uamUlso lm uuL ws m;lk sX m;k X; xL ulsl;C D X oXX ms l;au s a(sl m oXlsl; C Df lu s X u a(sl m oXlsl;C D6 aX a(sl a;(lm u xousl(u ; u Xa;l; C D sb s l; c U aX +msl a L (a;lslk )

W)� b uu aoms xo;s maXx u CWc%®J a sas u uLx(ba Ls ;D lm ;o i s;nba b k mas X lk masb X uu (u slmU sb X (L lm sb ( ;s L X) aXsba; am uu (u slmU sb X (L nlsblm sb ( ;s L X6 uu aoms a su ;s ®)WJ a sas u uLx(ba Ls ; l; m ;; XL)

E)� x u ;o i s l; ulUl u sa ms X sb sXl u l ;b l;3o� as (X Um ms aX moX;lmU0o� mamc blu XlmU (as msl u Cl) ) nax m nba b k b

bL;s X saxL6 X (a;scx ma( o; u6 nbl b l; lm ; 5% L X;nlsbaos x m; ; aX6 lm x u ;o i s; nba b k m (a;scx ma( o; u aX q% L X;6 xo;s amlXx nlsb auul uslxou slmU aXxam C D m ;sX lau u k u;D6 b k asb ak Xl ;

;oXUl uuL X xak aX b k oXX ms a ox ms so u ulU slamD

blu c XlmU (as msl u Cl) ) nax m nlsb om slam u ak Xl ; m maa ox ms lx( lXx ms a akl o s u aX os Xlm om slam sb s naouo; ;s XlulsLD) bl; s UaXL lm uo ; nax m nlsb

aulUax maXXba C k m ; k X D6 nax m nba X ( Xlx ma( o; u aXb k io;s Uom sa x m;sXo s )

o� o i s b ; m U slk ; Xox (X Um m L s ;s s ; X mlmU m UX ;sa am a sb auuanlmU3)� ax(u s ;slm m Xax lms X aoX; aX sb ( Xla Xax

am; ms lmsa sb sXl u omslu E xamsb; s X sb u ;s a; almk ;slU slam u (Xa o s0 aX6

)� am;l;s ms m aXX s o; a am a sb auuanlmU (s ux sba ; a lXsb amsXau aX sb ( Xla Xax am; ms lmsa sbsXl u omslu E xamsb; s X sb u ;s a; a lmk ;slU slam u (Xa o s3l)� X u amsX (slk ; C lsb X ax lm aX (XaU ;s Xam amuLDll)� mi s u (XaU ;s Xamlll)� kamaXU ;sX u lx(u ms;lk)� ;sXaU ml k Ulm u XlmUk)� X os m ao; amsX (slk ( s b ;kl)� msX os Xlm kl C D aX lmsX os Xlm ;L;s x C D nlsb

a ox ms luoX X s a q9J ( X L Xkll)� u ( Xsm X ;s XlulF slam Ck ; saxL nlsb a ox ms slam

a Faa;( Xxl D (XlaX sa sb x u ;o i sh; msXL lmsa sbsXl u0 sbl; x u xo;s sb ;au ( Xsm X aX sb ;o i s

klll)� ao u XXl X x sba 3 am ax m m a uo;lk (C l (bX Ux aX Xkl ufk ous (;D nlsb k Ulm u;( Xxl l u U ms Ca xfU ufluxf X xf;o((a;lsaXLD)

3 OUGBNC KBR KB

o i s; x slmU mL a sb auuanlmU Xls Xl X CNR ulUl u m mmas mXauu lmsb sXl u3

9)� oXX ms kl m aX tmanm bl;saXL a ulml uuL ;lUmll ms lm slamlm uo lmU3

)� bXaml aX amUalmU slk lm slao; l; ; X TolXlmU uamU s Xx;L;s xl sX sx ms ;o b ;6 os mas ulxls sa3 (XaUX ;;lk xousla uu ota m (b ua( sbL C D6 bXaml X m u lm slam6 bXaml b ;slm slam nlsb Xam bl s ;l;6 so X oua;l;6 aX slk b ( slsl; )

)� X klao; ; Xlao; a((aXsoml;sl aX sL(l u lm slam;))� l;saXL a (a;lslk ; XauaUL aX b ( slsl; ))� XlaX bl;saXL6 aX ;o;(l lam6 a so X oua;l; C D))� l;saXL a (a;lslk ; XauaUL aX )

%)� l;saXL a ulml uuL ;lUmll ms sX ox C )U) sX ox sl X lm lmioXL6X X u amso;lam6 ;(lm u aX ax(X ;;lamD

8)� ;s aX oXX ms bl;saXL a x l uuL ;lUmll ms k X; s; Clm uo lmUuu XUl X slam;D Xax3

)� aXsl a;s Xal ;)� l(b mbL X xlm)� oXlm aX xao; fbox m blx Xl msl a l ;

+)� ;s aX oXX ms x ulUm m L6 w (s aX)� Xkl u X lmax s U 9 aX u ;;)� amclmk ;lk ; u uu m ;To xao; uu ;tlm X lmax)� m X l Uma; ; nlsb oX slam a ax(u s X ;(am;

CX xl;;lamD 5W L X;ABGRNKr N A F RNONTB F OBTC C r 3 OU G GU L R KNF

S KRB BS RBNCt K T K O GG N K GSNCG o

W)� lUmll ms am oXX ms6 om amsXauu x l u am lslam lm uo lmU6 os masulxls sa6 X l 6 X m u6 b ( sl 6 b x sauaUl u6 U ;sXalms ;slm u6 m a Xlm 6lxxoma l l m L ;Lm Xax 6 (ouxam XL6 X X u6 (;L bl sXl 6 aXm oXauaUl u l; ; nbl b aou s sb ;o i sh; ; sL6 lx( lX sb;o i sh; X ul u ( Xsl l( slam lm sb sXl u6 lx( lX sb k uo slam am (alms;6 aX m ;;ls s sb o; a x l slam mas uuan L sb (Xasa au6; s Xxlm L sb a sb sXl u)

E)� ; a m lmk ;slU slam u XoU aX asb X w( Xlx ms u sb X (L aX am lslamasb X sb m nlsblm + n t;6 W (b Xx atlm sl b u ulk ; aX oX slam alauaUl u s Cnbl b k X l; uamU XD (XlaX sa ; X mlmU)

G)� oXX ms ( Xsl l( slam lm mL asb X lms Xk mslam u ulml u sXl u) Xsl l( slamlm mamclms Xk mslam u sXl u X TolX ; ((Xak u a sb (Xasa au L lmk ;slU saX)

I)� o i s; nba X am oXX msuL X lklmU mL asb X lmk ;slU slam u U ms;6 aXb k ( Xsl l( s lm m lms Xk mslam u ulml u sXl u nlsblm sb u ;s %9 L;6aX ;o i s; nba b k m k lm s nlsb ulk k lm q % xamsb; (XlaXsa sXl u lm uo;lam)

S)� o; sb X l; m omtmanm os (as msl u Xl;t aX k X; k ms; lmmoX;lmU lm ms; ; am XL sa sX sx ms a sb xasb X nlsb o ulsowlxX ;s lmU ;baou l; amslmo l sb xasb X l; mXauu )

UF K NGU L RG

lk CWD ;o i s; nluu mXauu sa X lk H ;s Xal ;)

NSUO RBNCG

CR CRBNCl Nl K R g 4 r uu ;o i s; nba X lk am a; a sXl u x l slamC D

K KNRN NO g 4 r uu ;o i s; nba ( XaXx uu kl;ls; lm aX m nlsb(Xasa au nlsbaos ;lUmll ms (Xasa au kl slam; aX klau slam;

Rr NSUO RBNC r uu ;o i s; sb s X lk am a; a sXl u XoU C D

R RBGRB O BGGU G

Xlx XL sL ;; ;;x ms;3 ;oxx XL a sb mox X m ( X ms U a ;o i s;nlsb mL k X; k ms C D6 mL ; Xlao; k X; k ms C D6 k X; k ms;u lmU sa ( Xx m ms l; amslmo slam a sXl u XoU m sXl u XoUcX u s k X;k ms; nluu X (aXs )

am XL l L ;; ;;x ms;3 b mU lm m oXauaUl aos ax ; am sb 6 lx%Wc aas ut m ; u ; Xax xl;;lam sa l; b XU C L W aX %9D6 mauuan o( C L; S® m 9I®D nluu m uLF L ( lX scs ;s; nlsb ;lUmll ms (ck uo ; am;l X u ;; sb m ®)®W) ulml u m oXauaUl lx(Xak x ms l; axxamuL

a ; Xk lm 5 EEJ a ;o i s; sX s s sb abm; a(tlm; a;(ls u) bUX a lx(Xak x ms lm sbl; sXl u (a(ou slam b ; mas m To s uL To msll

bl;saXl uuL) L 6 u mUsb a % bL( Xclms m;lsL m u mUsb a 9c(a;s amsX ;smb m x ms ;baou ;s u aX X o L l; b XU ) ( lX scs ;s nluu o;sa ax( X sb ; k uo ; nlsb ;lUmll m am;l X s (ck uo ; u ;; sb m ®)®W)

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b ; x(u ;lF a W ;o i s; lm sbl; ;lmUu Xx ;so L C H ;s Xal D l; ; am ;l lulsL m uaUl;sl u am;l X slam; am sb mox X a ;o i s; sb s nluu m;oXX ul u ; sL X (aXs a o ulsowlx cx l s uu; (u slam lm sb ( sl ms(a(ou slam)

m lm ( m ms s m sL amlsaXlmU a X C D nluu ax(a; a lkx x X; nlsb s u ;s am x x X nba l; m m slao; l; ; ( l ul;s6

x sauaUl;s6 oXauaUl;s6 s sl;sl l m6 m masb X lm ( m ms w( Xs nlsbw( Xl m am ;; ;;lmU ; sL) bX a sb x x X; nluu am ;s s sbabm; a(tlm; mlk X;lsL) b nluu X kl nlmU sb ; sL s s X sb lX;ssna ;o i s; X mXauu m ax(u slmU sb s Xal X sx ms b ; sa s Xxlml ls ; sa amslmo sb sXl u) b nluu ;o xls sb lX lm lmU; sa sb (am;aXs X k XL x slmU m sa sb ) x slmU; m lmc( X;am aX kls u am X m aX ax lm slam a sb asb) b s sa o; aX X kl n L sb

nluu so u X n s X aX lm sb s ; ) b ulml u s nluuxamlsaX L b X ( osl ; m nluu To XLcX (XlaX sa X kl n L sb )

UK RBNC NU L RKRB BS RBNC

( sa S xamsb;

K DB RBNCG C BCBRBNC N KFGmsl a Lmsl a Lc ( m ms uuou X Lsasawl lsLk X; k ms

ut ulm ba;(b s ;u mlm xlmasX m; X ;

+ To (aXlmc+;( Xs s xlmasX m; X ;m saxl b X ( osl u ;;lu s X u (sl oXlsl;u loxax(u s uaa uu aomsax(u x msc ( m ms Lsasawl lsLbXaml Lx(ba Lsl ot xl; (aXs aXxmsX u Xkao; L;s xamsX s ; X b XU mlF slamaxxam XxlmauaUL Xls Xl aX k X; k ms;oXXl ouox ls

6 Ls m sL amlsaXlmU a X

sbl ; axxlssu sXa X laUX xw( m l; lulsL s so; uX Ux ms mslU m lm lmU CX UlamDX Ux ms XL;s uulF u CX UlamDauuanco(aa ulml u X sllUb amsX ;s l;o u olsL

f m ( m ms sbl ; axxlss C D aX m;slsoslam u kl n a XC D

U xxomaUua oulmms Xm slam u am X m am Xxaml; slam a bml u TolX x ms;aX Ul;sX slam a b Xx osl u; aX ox m ;mk ;slU slam u l lm u Xa o sm;slsoslam u kl n a XmsX k mao;

t tlua usams s bL XaU m ;

amUlso lm uuL ws m;lk X m;k X; L ulsl;an ;s k u Xx

m ;l m lxx ama uam u msl a L

l u l slam XL aX Uou saXL slklsl ;Um sl ;am m x UlmUousl(u u Xa;l;

c slam u m X m;slsos r aXtlmU Xao(oXaxL ulsl; (sloXaxL ulsl; (sl ( sXox l;aX X

(sl a;(lm u ; u Xa;l;

K DB RBNCG C BCBRBNC N KFGb Xx a Lm xl aX XaUX ;;lk l; ;XaUX ;;lk ousla u ota m (b ua( sbLX Xasa au sX XX XxX XX xm axlF ulml u Xl uoXX ms ;au s (sl oXlsl;

Xlao; k X; k mss sl;sl u m uL;l; u m

x oxx XL a Xa o s b X s Xl;sl ;L;s x XU m u ;;Xox Xas lm u sXa(baX ;l;

s9f% uc l a ulxlm slaml;lsaXu usb XU mlF slam

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0o0�oXaxL ulsl; (sl C D l; ; k X 6 xL ulm slmU osalxxom l; ; a sb msX u m Xkao;

;L;s x sb s (X X msl uuL s; sb a(sl m Xk ; m ;(lm u aX ) usbaoUb bl;saXl uuL am;l X;o sL( a xousl(u ; u Xa;l; C D nlsb ak Xu ((lmU ;Lx(sax;6 l; l;slm s X lauaUl uuL m

(XaUma;sl uuL m b ; ( sba(bL;lauaUL omX ;(am;lk sa sL(l u sX sx ms; 2 lm;b mt X%®®G0 lx XaoUb6 s u)6 %®9%.) m %®®+6 m msl a L s XU slmU sb n s X b mm u (Xas lm6To (aXlmc+6 n ; aom sa ;;a l s nlsb ) ax( X sa 6 wbl ls; m au X U sam; s6 (aaX X (XaUma;l;6 m X XlsL a X Xa;(lm u uol aulUa uam u U m ;) ss t;sL(l uuL (Xa o xa X s sa ; k X l; lulsL sb s u ; sa oxou slam a l; lulsL nlsb bss t0 sn m ss t;6 ( sl ms; U m X uuL X x lm m oXauaUl uuL ;s u nlsbaos kl m a(XaUX ;;lk s XlaX slam) b X aX 6 ls l; Xo l u sb s UUX ;;lk sX sx ms aX b X u (; l;a(slxlF sa (X k ms l; lulsL)

s; (X axlm msuL x u ;6 nlsb x u sa x u X sla a E)W39) b X u slk X To m L axamU xL ulm slmU l;aX X; l; Tols k Xl u 6 lmU blUb X lm ;l m6 l;( ml m Xl m

(a(ou slam; ax( X sa nbls ;) b n (a(ou slamc ; (X k u m ;so l ; a am o s(Xakl (X k u m X s ; a ®)8% sa 8)9 ( X 9®®6®®® lm sb mamcnbls (a(ou slam 2 m b Ua( u6 su)6 %®9®.

ulml uuL lmls l; lm L bl;saXL a a(sl m oXlsl; m bl;saXL a sX m;k X; xL ulsl;nlsb mamc X lm 6 uamUlso lm uuL ws m;lk xL ulsl; u ;lam; m faX (X ; m a sb c Ulax Xt X) Xam U slk ( sl ms; nlsb sX m;k X; xL ulsl; m a(sl m oXlsl; xo;s b k

uamUlso lm uuL ws m;lk xL ulsl; m X lm sb s l; mas sL(l u aX xousl(u ; u Xa;l;)( sXox l;aX X C D l; lm ; + msl a L (a;lslk lm lkl o u; nlsb I r a(sl

m oXlsl; aX�sX m;k X; xL ulsl;)

ax(Xl; sb ;( sl uuL ulxls ;Lm Xax ; a uamUlso lm uuL ws m;lk sX m;k X; xL ulsl;C D6 X oXX ms l;au s a(sl m oXlsl; C Df lu s X u a(sl m oXlsl; C D6 m ;l ma(sl a;(lm u xousl(u ; u Xa;l; C D6 ; uamU ; ( sl ms; s ;s (a;lslk aX sb mslc + msl a L2 uum X6 s u)6 %®9®.) lFFa a6 s u)6 X (aXs sb s G a 98 CWEJD ( sl ms; Xax o; mL

k ua( ulml uuL lmls s X auuanco( slx a s u ;s % L X; nlsb sb asb X ;lw C+EJDX x lmlmU ) lm;b mt X s u)6 (Xa;( slk uL ;so l %S ( sl ms; nlsb lX;s k ms a )lsblm 9 L X6 E a sb 99 ; Xa(a;lslk C +HD ( sl ms; b X u (; a xL ulsl; Clm l slk a

X oXX ms sX m;k X; xL ulsl;D aX k ua( a(sl m oXlsl; Clm l slk a m oXaxL ulsl; a(sl D) LamsX ;s6 ma ; Xam U slk ( sl ms; X u (; ak X 9rG L X; auuanco() m ;l m b k;lxlu X m oXalx UlmU6 ; XauaUl u6 m lxxoma( sbauaUl u b X s Xl;sl ;6 m sb l X m l;(Xlx XluL am a u ;;ll slam ; lm ( m sb ; lm lkl o u; X l Uma; nlsb 6 os lm aXsbx Xl m oXa( 6 sb ; ( sl ms; X l Uma; nlsb 2 s;oat 6 s u)6 %®®G0 lmU X bot su)6 %®®G.)

b oXX ms ;s m X a X aX sX sx ms a os ss t; a asb a(sl m oXlsl; msX m;k X; xL ulsl; l; Wc L aoX; a blUb a; x sbLu(X ml;auam C9®®® xU luLDC lx XaoUb%®9%D) m ;ax ( sl ms;6 sbl; aoX; a ;s Xal sX sx ms l; ;ol l ms sa ;o((X ;; lmu xx slamm X k X; ;ax m oXauaUl L;om slam) saX; sb s x L (X l s ;o ;; nlsb ;s Xal ; uamlm uo ;x uu u ;lam oUbs XuL lm sb (Xa ;; m am oXX ms (X k mslklxxoma;o((X ;;lam) m x mL ( sl ms;6 ;s Xal ; X mas ;ol l ms sa ;o((X ;; lmu xx slam6m sX sx ms ; u slam sa (u ;x w b mU l; m ;; XL) lk L u ; a 9)® r 9)W kauox w b mU ;X TolX m lslam u %cn t lm( sl ms ba;(ls ulF slam m msX u ulm sb s X) u ;x w b mUXXl ; +c9®J Xl;t a ulm lm slam aX sbXax asl ax(ul slam;) ;(ls sb ; Xl;t;6 (u ;xw b mU l; ;s m X a X lm ;s Xal comX ;(am;lk ( sl ms; o; ls l; W®cG®J slk lmX o lmU slk lmu xx slam m X o lmU lmu xx saXL x U lm sbl; ( sl ms (a(ou slam

C F F (laXtan;tl %®9®D) uslx s uL6 m oXauaUl X ak XL s X blUb a; ;s Xal ; m (u ;xw b mU m ;sX sll lmsa sbX UXao(;3 UXao( sb s a ; mas lx(Xak s uu6 UXao( sb slx(Xak ; ;ax os x lms lm; ;lUmll ms m oXauaUl l ls m UXao( sb s lx(Xak ; n uu l mas

t sa ; ulm )

b X slam u aX o;lmU o ulsowlx l; ; am sb tmanm Xau ; a uu;6 msl a L (Xa o slam m(u ;x uu; lm sb ( sba(bL;lauaUL a ) l; b X s XlF L sb (X ; m a m mslc +msl a L6 nbl b m amuL (Xa o L l X msl slam a uu; sa (u ;x uu;) o; sb ;mslc + msl a l ; x L ( sbaU ml 6 uu; X aUmlFlmU + x L lX suL lmkauk lm sbl; ; (Xa ;; ; n uu) uu; u;a (u L Xau ; (as ms mslU m (X ; mslmU uu; lm ) b

;sXamU ;s kl m a sb lx(aXs m a uu; lm ax ; Xax ;so l ; a uu (u slam6 xa;saxxamuL nlsb mslc %® xama uam u msl a L6 Xlsowlx C lsow m4D) lsowlx b ; m ;banmlm lk X sXa;( slk m sna (Xa;( slk ;so l ; sa slk lm X o lmU X u (; ; o( saS®J m bl klmU X xl;;lam lm o( sa I®J a ( sl ms; ;au uL L ls; slam am %®H uu;6 ;(lsma b mU lm (u ;x uu (a(ou slam m mslc + msl a L sls X;) b ; box m sXl u; ;sXamUuL;oUU ;s Xlsl u Xau aX uu; lm sb ( sba(bL;lauaUL a box m l; ; ) blu sL(l uuL o; lmsb (X k mslam a l; ; 6 c uu (u slam x L m l l u lm sb sX sx ms a m os X u (; ;n uu) x XUlmU kl m lm l s ; sb s ( Xl(b X u uu; X slk s oXlmU X u (; m(u ;x u ;s (Xa o slam a mslc + msl a l ; ;(lt ;) uu; X u;a aom nlsblm os u ;lam;a sb ;(lm u aX m a(sl m Xk ;oUU ;slmU Xau ; asb lm sb uaa m lm sb msX u m Xkao;;L;s x oXlmU X u (; )�

0of�ETKNUCulsowlx l; mak u sblX U m X slam blx Xl mslc %® xama uam u msl a L la mUlm X aX

mb m slklsL6 wbl lslmU omlTo UuL a;Lu slam (Xalu nlsb uan Xo sa; ams ms)ulsowlx b ; m ;lUm sa lmsXa o ;o( XlaX msl a Lc ( m ms uucx l s

Lsasawl lsL C D nblu x lms lmlmU ax( slslk ax(u x msc ( m ms Lsasawl lsL C D)ulsowlx b ; u;a m xam;sX s sa lm o (XaUX xx uu sb C D) ulsowlx b ;omlTo (Xas lm ; To m 6 s XU slmU (lsa( ; am %® mas s XU s L Xlsowlx aX a soxox )

K OBCB O D OU RBNCG N OBRU3BF�� b xama uam u msl a L6 o ulsowlx 6 xam;sX s m mb m lulsL sa tluu bXaml

uLx(ba Lsl u ot xl C D uu; ax( X sa Xlsowlx ) ulsowlx xam;sX s lx(Xak NX (saX C N Df 9E lm lmU m N ( m ms saX om slam; ax( X saXlsowlx ) lslam uuL6 o ulsowlx lm o blUb X lm klsXa U lm;s uu;6 m blUb XN x l s lms Xu otlmc% C %D (Xa o slam L N H oXt s uu; 2 ax o s u) %®®I.)ulsowlx xam;sX s blUb U lm;s asb ( sl msc Xlk uu; m uu ulm ;)

U lm;s sb uu ulm xa;6 o ulsowlx n ; a ; Xk sa lmbl ls sb am;slsoslk uL slk cM ;oXklk u ( sbn L6 m lm o sb w(X ;;lam a uamU nlsb lmbl lslam a sb 8 c( sbn L) ulsowlx u;a lm o sb w(X ;;lam a (Xac (a(sasl saX;6 ; m;lslFlmU xa; uu;sa x l s (a(sa;l;) 2 Xls tl s u)6 %®99.

�� b mslsoxaX s a o ulsowlx n ; ax( X sa sb s a Xlsowlx nlsb b xasb X (L lm

auul ou X uLx(bax C D6 m x msu uu uLx(bax C D w maUX s xoXlm xa u;) lmUu U mso ulsowlx xam;sX s a; cX u s mslcsoxaX slklsL nlsb 9®®J soxaX UXansb lmbl lslam lmsb w maUX s s a; a 9®®xUftU6 m ;o( XlaX soxaX UXansb u L C%9 L;D ax( X saXlsowlx ) ulsowlx u;a xam;sX s ;o( XlaX mslcsoxaX slklsL ax( X sa XlsowlxU lm;s w maUX s; s uu a; u k u;) 2 ;s k ; s u)6 %®99.

��A CNCl OBCB O RN3B NONTr SKNTK F. G S KNKF NK BCT RN V TUB OBC

I X ulml u sL k uo slam a las bmauaUL Xlk b Xx osl u;e C mk ;slU saX Xa boX D)b sawl lsL ;so l ; ( XaXx sa ;s ul;b sb ; sL a o ulsowlx n X am o s aX lmU saaa aX saXL X sl C D X TolX x ms;6 lm uo lmU k ul slam a sb m uLsl u x sba o;

aX sb ; Xox m uL;l; a o ulsowlx ) b ulml u sawl auaUL ;so l ; am o s sa s nlsbo ulsowlx X ;oxx XlF lm u 9 uan)

O 0i N3B NONTr

rS N GRU r GR GrGR F RAN NFBCBGRK RBNC NG G SNKR C5

lmUu a;sawl lsL

LmaxauUo;xamt L

lmUu a; % n t;a ; Xk slam®6 ®)86 9® m 9®®xUftU

8%IGS ;

( s a;sawl lsL

LmaxauUo;xamt L

tuL aX + n t;®6 9® m W® xUftU 8%II® ;

Lsatlm X u ; LmaxauUo;xamt L

W6 %®6 E® xlmos ; mE baoX;9® m W® xUftU

8%II® ;

a u sau X m LmaxauUo;xamt L

+ n t;9® m W® xUftU 8%II® ;

a u sau X m n u mnbls X ls m lmUu a;

9® xUftU %®®G®E®W ;

os U ml lsLC x ; s ;sD

uxam uusL(blxoXlox m klsXa

f®6 96 86 9®6 8® m9®® ’Uf(u s

®G®W%% ;

xxomaU ml lsL LmaxauUo;xamt L

lmUu a; 6 %cn ta ; Xk slam®)86 9® m 9®® xUftU

8%IGS ;

xxomaU ml lsL LmaxauUo;xamt L

+cn t9® m W® xUftU 8%II® ;

3 msX ms Xm slam u awl auaUl ) iI ri I ti tl t t iIr ,c 3 msX b X b ; lauaUlTo ;C iIr tr t t ( r D) 3 m;slsos ;s oX luu C (I nr i(I InI D

m ;lmUu c a; sawl auaUL ;so l ;6 o ulsowlx l;(u L ; sL (Xalu ;lxlu X sa nb s xlUbsw( s aX mslc %® xama uam u msl a l ;) lmUu xlml;sX slam a o( sa 9®® xUftUo ulsowlx lm LmaxauUo; xamt L; n ; n uu sau X s 6 nlsb ma ua u lXXls slam nlsb lmsX k mao;

xlml;sX slam) masawl lsL ;so l ; C x ; s ;sD ;ban sb s o ulsowlx n ; mas xos U ml )amt L; sb s X lk ;lmUu lmi slam a ®)8 xUftU a o ulsowlx k ua( m mslco ulsowlx

X ;(am; 6 nb X ; mslco ulsowlx msl a l ; n X mas s s lm sb mlx u;6 nbl b X lk 9®aX 9®® xUftU C mk ;slU saX Xa boX D)

X ( s c a; sawl auaUL ;so L sX s LmaxauUo; xamt L; nlsb o ulsowlxlmsX k mao;uL s a; ; a ®6 9® aX W® xUftU n tuL aX + am; oslk n t;) s 9® xUftU6 makl m a sX sx mscX u s sawl lsL n ; a ; Xk w (s aX sb w( s (b Xx auaUl u sam nbls uaa uu m uLx(ba Ls aoms; C;x uu X ; o sa ua;; a uu;D0 ma sawl auaUl u s; am sb b x sauaUl u aX uaa la b xl;sXL ( X x s X; k uo s n X a ; Xk ) s W®xUftU a; 6 sna mlx u; (X ; ms nlsb (aaX U m X u ulml u ;lUm; CbL(asb Xxl 6 bL(a slklsL m(Xa;sX slamD) b x u ;ban sb ; ;Lx(sax; ;s XslmU am L 9W m n ; (X x soX uL; Xll am L %® s X sb sblX xlml;sX slam a o ulsowlx 6 nb X ; sb x u (X ; ms nlsbsb ; ulml u ;lUm; s X sb aoXsb lmo;lam m X ak X nlsb ;Lx(sax sl sX sx ms)

m X u slam sa sb (Xlx XL slklsL a o ulsowlx 6 uLx(bal (u slam n ; lm o lm sb ;(u m muLx(b ma ; s asb sb 9® xUftU m W® xUftU a; ;) m ;ax mlx u;6 X ; lm sbLxo; m;(u m n lUbs; n ; a ; Xk ) l;sa( sbauaUl u w xlm slam ;ban ;(u m m uLx(b masXa(bL6 xaX (Xamaom s sb W® xUftU a; ) lslam u b mU ; slmU sbb x sauLx(ba(al sl ax( Xsx ms C %®c w(X ;;lmU uu;D n X aom lm sb uomU;6 ulk X6 tl m L;6

X m u; Cu ota Lsa;l;6 wsX x ouu XL b x sa(al ;l;D m am x XXan Clm X ;xL ual f XLsbXal X slaD) m l X ms aXU m; a ;ax mlx u;6 x mL lxx soX uu; n X a ; Xknlsblm sb k ;; u;)

( sl lmu xx slam n ; xam;sX s s sb 9® xUftU a; lm 9 a E mlx u;) l;sa( sbauaULxam;sX s p uo;s Xe a b ( sl u ;lam;3 xlmlx u ;lmUu uu m Xa;l;6 ;ulUbsuL slk s o( Xuu; m xlmlx u lmu xx saXL b mU ;) s ;baou mas sb s sb c uu (u slam lm sb

( Xl(b X u uaa ; n uu ; lm am x XXan n ; ( Xsl ou XuL x Xt lm sbl; mlx u0 o(am m Xa(;L6X o slam a c uu; n ; SSJ lm sb am x XXan6 nb X ; sbl; k uo X b ((Xawlx s uL EIJlm sb asb X xamt L; sX s nlsb 9® xUftU) s sb W® xUftU a; ;lmUu c uu m Xa;l; n ; xlmlx uCm/%D aX ;ulUbs Cm/%D aX + a sb E xamt L; m slk slam a sb o( X uu; n ; ;ulUbs Cm/%D aXxa X s Cm/9D lm 8 aos a sb ; + mlx u;) ax lmu xx saXL b mU ; n X mas )

(a;;l u bL(asb ;l; sa sb a ; Xk xlmlx u b ( sl u ;lam; l; sb X ;oXU m a ( sbaU m;o; L sb lxxoma;o((X ;; ;s s a sb mlx u) ; sb ulk X mFLx slklsl ; C 6 D

n X mas xa ll m ;lm o ulsowlx l mas Xa;;cX s nlsb sb ulk X lm sb sl;;o c Xa;;X slklsL ;; L6 sbl; lm lmU n ; am;l X mamc k X; s) ; am sb ; sawl auaUL;so l ; lm mamcbox m (Xlx s ;6 sb ulk X aou s XU s aXU m m ;( l u ss mslam ;baou( l sa b ( sl xamlsaXlmU6 m sa ;o ulml u lm slam;6 nbl b m lx( s b ( sl ( X x s X; ;o b; bXaml b ( slsl;)

OBCB O D ONSF CR N OBRU3BFa s 6 88 ( sl ms; nlsb X u (; aX X X saXL b k m sX s lm lX;sclm box m a;; u slam ;so L C(Xasa au %®c®G®8D) sl ms; X lk lsb X am n tuL lmo;lam a ;lmUu U mso ulsowlx aX + a; ; s W l X ms a; u k u; C( Xs D aX n tuL Ic a; X Ulx m s am a;u k u C( Xs D) Xs o; m lmlsl u a; a 9W® xU auuan L G a; ; a +W® xU Csas u a; 88®®xUD)

A KF NEBC RB Gs X lmi slam a o ulsowlx nlsb 9W® xU a; auuan L ; k m n tuL lmi slam nlsb +W® xU6

X ;ous; ;oUU ;s mamculm X (b Xx atlm sl ; nlsb a; C+W® xU k; 9W® xUD m slx Cn t + k;n t ID3 xaX sb m (Xa(aXslam u lm X ; a x w m : o sa u X m X ; ) bkauox a l;sXl oslam s ;s L ;s s n ; ;x uu CzW D6 ((Xawlx s uL To u sa uaa kauox )b ; mamculm X (b Xx atlm sl ; x L w(u lm L lm lmU a o ulsowlx sa ls; s XU s6 nlsb

u XU ax(am ms a s XU scx l s ulxlm slam s X sb lX;s a; sb s l; X ; s X;o ; To ms lmo;lam; o sa X o slam lm sb k lu u s XU s) an k X6 ulxls s aX b a;u k u abaXs m am;l X u k Xl lulsL lm ; ulm ( sl ms b X s Xl;sl ;6 ( Xsl ou XuL lm s Xx; asoxaX oX m6 x t lXx am uo;lam; ll ous)

b ulm X x m ; Xox am msX slamcslx ; (Xalu s X sb lX;s6 sb aoXsb m sb lUbsb lmo;lama o ulsowlx X (X ; ms lm lUoX 9) ;oxx XL a mamc ax( Xsx ms u ( X x s X; s Xsb lX;s6 sb aoXsb m sb lUbsb lmo;lam a o ulsowlx X (X ; ms lm u %)

BTUK 0i BC K F C G KUF NC CRK RBNClRBF G SKNBO R K RA BKGRt RA NUKRA C RA BTARABCUGBNC N U OBRU3BF

C8 ( sl ms;0 SJD) s XoUcX u s ;6 l) ) a oXXlmU xaX sb m am n t s X sb u ;s lmo;lam ao ulsowlx 6 am;l;s ;; msl uuL a lm slam; Cm/9%D m m osXa( ml Cm/+D)

n msLcsbX lmo;lamcX u s X slam; C ;D n X X (aXs lm %® ( sl ms;6 9E a sb x UX %m G C8 lm ( Xs 6 + lm ( Xs D6 UX 8) lws m a sb ; %8 ; a oXX s X sb lX;s lmo;lam ao ulsowlx 6 8 s X sb ; am lmo;lam m + s X ;o ; To ms lmo;lam;) X 8 lmo;lamcX u sX slam; X TolX lmo;lam lms XXo(slam m X ;auk nlsbaos ; To u s X ;Lx(sax slsX sx ms ;o b ; aXsl a;s Xal 6 mslbl;s xlm ;6 awLU m sb X (L6 m Xam ba lu saX; lm ; aXam ba;( ;x)

n msL sbX (l;a ; a XoUcX u s (LX wl n X X (aXs lm %® ( sl ms;0 xlu Cq 8S1 D aX %®(l;a ; m xa X s CXax 8S sa +®1 D aX 8 (l;a ;) b ;6 bluu;6 m o; m ;sb mln X uu X (aXs ; xlu sa xa X s ;)

ls m XoUcX u s lm slam; n X X (aXs lm S ( sl ms;) m a sb ; h; n X xlu saxa X s X ;(lX saXL sX s lm slam;6 b X( ; X oXX m ; aX m u ; ;; ;) m UX 8 ul;s Xla;l;n ; l Uma; s sb slx a sb +sb lmo;lam auuan L UX 8 Xam ba(ouxam XL;( XUluua;l; % xamsb; u s X) m UX 8 k Xl uu n ; X (aXs lm am ( sl ms m X TolXsX sx ms nlsb L uaklX) masb X ( sl ms nlsb x l u bl;saXL a aXsl k uk X (u x ms m;s (bLua a u m a X lsl; X lklmU o ulsowlx (X ; ms nlsb % UX + (l;a ;6 Ir hIt t n(

I ; (;l; sb m I h t t n( nr n( ; (;l; nlsb m a X lsl;) kauoslam n ; kaX us X msl lasl sb X (L) uu sb ; lm slam; X ;auk nlsbaos ; To u w (s I h t t n( nr n(; (;l; ax(ul s nlsb m a X lsl;6 nbl b X ;auk s X k uk X (u x ms)

n msL (l;a ; a XoUcX u s m osXa( ml n X a ; Xk lm 9W ( sl ms; ; n uu ; % lslam u; ; a Xlu m osXa( ml ) lUbs (l;a ; C+®J0 + lm ( Xs m + lm ( Xs D n X UX 8

m osXa( ml m G (l;a ; C8WJ0 8 lm ( Xs m + lm ( Xs D n X UX +) m ( Xs 6 uu (l;a ;os am a oXX nlsblm I L; s X sb lX;s a; m X ;auk ;(ams m ao;uL ;(ls amslmo slam

a sb sX sx ms nlsb o ulsowlx ) L amsX ;s6 lm ( Xs 6 UX 8c+ m osXa( ml n ; a ; Xk s Xsb sblX lmo;lam lm 8 ; ;6 s X sb Gsb aX Isb lmo;lam lm 8 ; ;6 m u s X lm sb u ;s sna ; ;)X sx ms nlsb UX moua Ls auamL ;slxou slmU saX C c D n ; ;s Xs lm + ; ; u lmU sa

X ak XL sa maXx u k uo nlsblm 9 sa 8 L;) aoX ; ; X ;auk ;(ams m ao;uL)

u k m (l;a ; a XoUcX u s sbXax a Lsa( ml n X X (aXs lm 9® ( sl ms; am;l;slmU a 9®UX 9c% m 9 UX 8) lm a sb (l;a ; X (aXs a oXX u ;; sb m +Ib s X sb ;s Xs ao ulsowlx lmo;lam)

XoUcX u s ( m Lsa( ml n ; X (aXs lm 8 ( sl ms; C9 UX 8 m % UX + (l;a ;D) aX uu asb x6 xlu sa xa X s (X c wl;slmU ( m Lsa( ml n ; (X ; ms s ; ulm ) uu os am ( sl ms ouuLX ak X ) b u ;s am n ; (X x soX uL nlsb X nm Xax sb ;so L o sa l Uma;l; aam axls ms ; am XL u ot xl )

lw ( sl ms; b w( Xl m am XoUcX u s u k s ulk X mFLx k ms6 Cl) ) lm X ; ak X %w lmuam 6 aX f ut ulm ba;(b s ; X sla 5 aX To u sa WD C; u 8D) lk aos a sb ; E

(l;a ; n X UX 8 ; nb X ; sb Esb n ; UX %) aoX (l;a ; a oXX ;aam s X sb lX;slmo;lam6 am a oXX s X sb ; am lmo;lam6 m sb u ;s am n ; a ; Xk s X sb +sblmo;lam lm ( sl ms nlsb x l u bl;saXL a bXaml xlw b ( sa uuou X m bau ;s sl ulk Xl;aX X) uu a sb x n X ;Lx(sax sl 6 l;au s 6 m sX m;l ms) lsb X lm X ; u k u alulXo lm maX lx( lX (Xas lm ;Lmsb ;l; n X X (aXs ) ak XL n ; ;(ams m ao; nlsbaos

X oXX m s X ;o ; To ms o ulsowlx lmo;lam)

O pi K flp O D R OBD K CarF GUGS R RN K O R RN U OBRU3BF

NANKR RB CR CUF K K

®9c®9 8®Gc®8 8®%c®% %®8c®8 8®8c®E %®9c®E 8

a ( sl ms; n X aom sa (a;lslk aX mslco ulsowlx msl a l ; o( sa 9% xamsb; s X sb;s Xs a sb ;so L)

xamU sb 89W aX x mslam ;6 8S n X X (aXs ; ; Xlao; k X; k ms; C D6 %8 a sb xlmU ;o;( s sa X u s sa sb ;so L XoU C; u +D) s l; sa mas sb s sb ; %8 ;

a oXX lm 9W ( sl ms;) uu a sb ; ; X ;auk nlsbaos ; To u w (s I h t t n( nr n(( h( ( C( sl ms ®+c®+D m ; a ( m Lsa( ml o sa ; am XL u ot xl aX nbl b sb ( sl msn ; (X x soX uL nlsb X nm Xax sb ;so L)

O xi KUTlK O R G KBNUG D KG D CRG OBGRBCT

NANKR RB CR CUF K K m®Wc®9 mo;lam X u s X slam 8®Gc®9 l;s Xla;l; 8®Gc®9 Xam ba(ouxam XL ;( XUluua;l; 8®9c®8 LX wl %®+c®+ sX (sa a u ; (;l; +®+c®+ s (bLua a u ; (;l; ax(ul s nlsb m a X lsl; +®9c®+ Xlu m osXa( ml 8®%c®% os lmo;lam X slam 8®%c®% m Lsa( ml +®8c®+ os lmo;lam X slam 8®8c®+ Xl uu 8®%c®8 osXa( ml +®%c®8 LX wl 9®8c®E u k s lk X mFLx ; 8®8c®E osXa( ml 9 +®8c®E osXa( ml % +®8c®G LX wl %®8c®S os lmo;lam X slam 8®+c®W os lmo;lam X slam 8®Ec®E os lmo;lam X slam 8®8c®I osXa( ml +®9c®E m Lsa( ml +®9c®E Xlu m osXa( ml 8

, aX lmU sa k8

am a sb aX x mslam ; b ; m am;l X ; a; culxlslmU sawl lsL aX lmU sbio Ux ms a sb ;so L sL axxlss ) b X aX 6 sb x wlxox sau X s a; b ; mas mX b L s)

B rxaUX (bl s aX sb ( sl ms; mXauu lm sb ;so L n X ; auuan;) b x l m U a sb 88

( sl ms; n ; E+ L X; CX mU +8cGGD) sl ms; b X lk 8 CX mU 9cID ulm ; a msl m X sb X (L(XlaX sa ;so L msXL6 E a sb x X X saXL sa sb lX xa;s X ms sX sx ms) lUbs m ( sl ms; CWWJDn X (X klao;uL sX s nlsb Xlsowlx c ams lmlmU sb X (L s sb slx a lm uo;lam lmsa sb ;so L)uu ( sl ms; os am (X ; ms nlsb uLx(b ma mu XU x ms6 99 C88JD a sb x b klmU outL

C5W xD uLx(b ma( sbL) n msL am ( sl ms; CEIJD (X ; ms nlsb ;(u max U uL m W C9WJD

nlsb b ( sax U uL) l m uaa uLx(ba Ls aoms n ; 8E)G w 9®Sf CX mU +)8Gc%9+D) l mb xaUua lm m (u s u s u k u; n X 99)S Uf u m 9®G w 9®Sf 6 X ;( slk uL) blXs m C8SJD( sl ms; b m U k uo qE Uf )

ulml u X ;(am; n ; ; am sb Xls Xl ;s ul;b L sb slam u m X m;slsos C DcaXtlmU Xao( o( s lm %®®I CWD) ;(am; s n X k lu u aX %S ( sl ms;6 9I aos a %9 lm

( Xs m 99 aos a 9% lm ( Xs ) a ax(u s X ;(am; ; n X a ; Xk nb s k X sb abaXs;)n uk C+9JD ( sl ms; n X lm ( Xsl u X ;(am; C D s xamsb +6 Wf9I lm ( Xs 6 m Gf99 lm ( Xs )n ; amlXx % xamsb; u s X lm I C%IJD ( sl ms;6 8fW lm ( Xs m WfG ( sl ms; lm ( Xs )

FFUC RGlUmll ms uaa uLx(ba Ls (u slam n ; a ; Xk lm uu ( sl ms; X u slmU sb lms mlauaUl u slklsL a o ulsowlx ) m sb +c a; ( Xs a sb ;so L6 uLx(ba Ls (u slam n ;

x wlx u am n t s X sb +sb a; a o ulsowlx nlsb x l m uLx(ba Ls aoms a ®)S w 9®Sflm abaXs 6 aXX ;(am lmU sa SGJ X u slk b mU 6 ( X;l;slmU am xamsb u s X C; lUoX %D) m sbIc a; ( Xs a sb ;so L6 sb uLx(ba Ls aoms m lX n ; om b mU os (Xaaom C ua; sa S®JD

(u slam n ; ;o;s lm omslu E xamsb; s X ;s Xs a sb X (L)

BTUK fi C ONN rFSAN rR NUCR

RU B G BC S B O NSUO RBNCGulsowlx b ; mas m k uo s lm ( l sXl (a(ou slam;6 aX lm (X Um ms nax m)

0op�b sXl u nluu oslulF aX ;(lm lx UlmU nlsb m nlsbaos amsX ;s oXlmU sb sXl u aX X u (; ;6; ( X ;s m X a X am xl;;lam m aX X ; X b (oX(a; ; am auuanco() m ; ; a (aaXX slmlm u X m 6 amsX ;s nluu mas o; )

aX (oX(a; ; a sbl; sXl u6 sXl u ;s nluu X kl n ;s m X a X ; a sb ;(lm m faX a(slm Xk ;0 sb auuanlmU b X s Xl;sl ; nluu X aX aX X ; X b (oX(a; ;3

9)� mUsb a ; Ulss u ;(lm % u ;lam lm mslx s X; lm uu ;o i s; nba a s lm ;6 m%)� mUsb a ; Ulss u ;(lm 9c(a;s amsX ;s u ;lam lm mslx s X; m faX aX ls u 9c(a;s

amsX ;s u ;lam lm xluulx s X; lm sba; ;o i s; nba lslam uuL X lk U aulmloxamsX ;s)

;lmUu X X nluu X kl n sb aX X ; X b (oX(a; ; m nluu lm ( m ms a sb sXl u) bX X nluu u;a ulm sa sb slx ; To m ; a sb ; m;)

�Coho(t A - 75 m IV (N=4) Coho(t B - 200 m IV (N=2)Coho(t C - 510 m IV (N=3) Coho(t D - 1050 m IV (N=3)Coho(t E - 1650 m IV (N=5) Pa(t II - 3300 m IV (N=11)

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Time f(om the fi()t infu)ion (month))

0 1 2 3 4 5 6

0ox�uu ;o i s; nba lu sa ulml uuL X ;(am L L W lm sb s Xal X sx ms b ; nluu

X axx m aX (u ;x w b mU ; ( X ;s m X a X ) m l l u X ;(am; l; U m X uuLam;l X m lx(Xak x ms lm sb ;( ll l lsC;D sb s u sa sb ba;(ls ulF slam) ( m lmU amsba; ;( ll l ls;6 sb Xls Xl sb s X Xaoslm uL o; s abm; a(tlm; sa lm l s sX sx msX ;(am; C;D lm xasaX6 ; m;aXL6 osamaxl m kl;o u om slam X 3

9)� m lx(Xak x ms lm ;sX mUsb L sb asaX ; X b aom lu ;sX mUsb ; u L s u ;s 9 ouu(alms lm s u ;s sna l;au s xo; u ; a s u ;s am ulx 6 aX

%)� m lm X ; a sna L u somlmU aXt omls; lm s u ;s am s ulx )8)� x(Xak x ms lm an u m faX u X om slam Xax lm amslm m sa s u ;s ( Xsl u

kauoms XL amsXau)+)� m lx(Xak x ms lm kl;o u olsL o;lmU ;l m uu m Tolk u ms a V % ulm ;)

;o i s; a mas X TolX ; u slam sa (u ;x w b mU o; sb L ouluu sb ulml u Xls Xlak 6 m x L ( XaXx sa amlXx X ;auoslam a sb lmu xx saXL u ;lamC;D ax( X saxl;;lam ) ; am sb m asb X ulml u saX;6 sb sX slmU (bL;l l m x L (Xa sal; b XU sb ;o i s bax aX b mU sb (u m sa ; u s lxxoma;o((X ;;lam sa (u ;x w b mU

aX amslmo sX sx ms a sb os w X slam)aX l; b XU Xax sb ba;(ls u6 sb ;o i s nluu ; b ou aX auuan o( lm sb ulml aX

sb S® m 9I® L kl;ls;) lm lmU; L sb s x L lmuo m ; u slam sa (u ;x w b mUsL(l uuL lm uo ws m;lam a mb m x ms6 lmkauk x ms a m n X ; a sb m Xkao; ;L;s x aX mlm X ; lm sb X a % bL( Xlms m;lsL) l;saXl uuL xamU sb f ( sl ms; sX s sabm; a(tlm;6 ((Xawlx s uL W®J a f ( sl ms; lx(Xak Xax X u (; nlsb ;s Xal ;uam ) b asb X W®J X TolX ; u s X nlsb (u ;x w b mU )

u ;x w b mU X sx ms b ;baou ;o i s; mas x s ak ulml u Xls Xl sa l; b XU bax 6 ; u slam sa sX sx ms nlsb

(u ;x w b mU l; ;s m X a X )

b (u ;x w b mU sX sx ms (b ; Ulm; s sb m a sb s Xal X sx ms b ; m nluuu ;s o( sa 9+ L;) oXlmU sb u ;x w b mU X sx ms b ; 6 ;o i s; nluu om XUa 9)® r 9)Wkauox ; a (u ;x w b mU k XL asb X L aX lmU sa ;s m X a X ) s sb m a sbl; (b ; 6; am x L ( XaXx sa amlXx X ;auoslam a sb u ;lam) mL oXsb X os

lxxoma;o((X ;;lk sX sx ms aX sb os u X l; X TolX m (Xakl aX lmU sa;s m X a X 6 sb ;o i s nluu amslmo sa auuan aX ; sL l;;o ;6 os sb ulml u l L

s nluu mas lm uo lm sb ;s sl;sl u m uL;l;) l;saXl uuL xamU f ( sl ms;sX s s sb abm; a(tlm; a;(ls u6 ((Xawlx s uL SWJ a f ( sl ms; nba ax(u s(u ;x w b mU X l; b XU auuanlmU ax(u slam a sb (u ;x w b mU )

u ;x w b mU nluu ult uL u X X x lmlmU lX ou slmU o ulsowlx ) an k X6 L sb slx (u ;xw b mU l; lmlsl s am L E a ba;(ls ulF slam6 W L; s X sb XoU lmo;lam6 xa;s6 l mas uu6 a sblX ou slmU uu; nluu uX L b k m ulxlm s ; ;banm lm lUoX %) usbaoUb sb X l; maw( Xlx ms u (b Xx atlm sl s lm ( sl ms; nba om XUa (u ;x w b mU W L; s XX lklmU o ulsowlx 6 w( Xl m nlsb Xlsowlx 6 ;lxlu X uu (u slmU U ms6 o; lm sbl;( sl ms (a(ou slam ;oUU ;s; sb s os uu (u slam (XlaX sa (u ;x w b mU l; mas b Xxou ossb s a Xlsowlx x L n X a ;aam X sb m lm ( sl ms; nlsbaos (u ;x w b mU ) bl; x Lo sa s; a Xlsowlx aos;l a sb lX ou slam C )U)6 am x XXanD sb s maXx uuL u ; sa EcI

xamsb; a lX ou saXL uu (u slam) ; nlsb Xlsowlx 6 (u ;x w b mU x L u;a ;baXs m sboX slam a lX ou saXL uu (u slam o sa o ulsowlx lm ( sl ms;) b ; s; nluu

xamlsaX L xamsbuL uu aoms;)

f�b ak X uu a i slk l; sa ;; ;; sb ; sL a o ulsowlx ; cam sb X (L sa ;s Xal ; aX

sX sx ms a os a(sl m oXlsl; m faX sX m;k X; xL ulsl; lm m )

fo0�a ;; ;; ; sL a os uu (u slam lm ;o i s; nlsb os X u (; a a(sl m oXlsl; aX

sX m;k X; xL ulsl; nba X sX s nlsb o ulsowlx H ;s Xal ; UlmmlmU am a;xlml;sX slam m m lmU nlsb X (u slam a lX ou slmU uu;)

fof�g a s Xxlm sb uu (u slam (b Xx atlm sl ; a o ulsowlx lm sb ( sl ms(a(ou slam nlsb xamsbuL uu aoms;)•� a s Xxlm sb (b Xx atlm sl ; a o ulsowlx lm ( sl ms;)g a s Xxlm sb X To m L a k X; k ms; nlsb o ulsowlx lm sb ( sl ms(a(ou slam)•� a auuan ulml u m (alms; aX (X ulxlm XL kl m a l L) ulml u aos ax ; nluu

xamlsaX aX l L o;lmU sbX om slam u m oXauaUl s ;s;6 sb w( m l; lulsLs so; u C D6 lx %Wc aas ut m lUb amsX ;s l;o u olsL C D oXlmUxl;;lam sa sb ba;(ls u m sna auuan o( kl;ls;6 S® L; m E xamsb; s X

ba;(ls ulF slam) lslam u ulml u m (alms; nluu lm uo 3•� u ;lam ;lF•� ox X a L; lm ba;(ls u•� TolX x ms aX (u ;x w b mU X ; o sb X (L

g a ;; ;; aX sb s a lxxomaU ml lsL am sb (b Xx atlm sl ;6 (b Xx a Lm xl ;6m ; sL a o ulsowlx )

p�

po0�o i s; ulUl u aX mXauux ms xo;s x s uu a sb auuanlmU Xls Xl 39)� u m nluulmU sa (Xakl nXlss m lmaXx am; ms)%)� 9Ic9®® L X; a U )8)� n os a(sl m oXlsl; m faX sX m;k X; xL ulsl;) m n ulml u k ms l; lm ;

ulml uuL ;lUmll ms m oXauaUl l lsC;D am (bL;l u w x6 mas ssXl os u sa masb X l; ;(Xa ;;6 nbl b l; l X ms Xax ; ulm m oXauaUl u w x6 m ssXl os u sa u ;lam lm sb;(lm u aX 6 a(sl m Xk aX X lm;s x) n ;Lx(sax; xo;s X (aXs nlsblm 9® L; aam; s)

+)� lUbuL ;o;( s aX amlXx l Uma;l; a aX lmU sa sb %®®E X kl;lam; a sblmU X bot l Uma;sl Xls Xl aX C lmU X bot6 %®®ED6 aX + (a;lslk ( X sb

ol ulm ;) aX 6 ;o i s; xo;s b k sna ;auos Xls Xl 3)� a(sl m oXlsl;)� xL ulsl;

C s u ;s sna a sbX ;o((aXslk Xls Xl 3)� (X ; m a amslUoao; ;(lm u aX u ;lam ws m lmU ak X sbX aX xaX

k Xs X u ; Ux ms;6)� Xls Xl ; sl;LlmU sb X kl; am u l Uma;sl Xls Xl aX

2 aux m6 %®99.)� c U C +D lm ; Xox)

aX 6 ;o i s; xo;s b k uamUlso lm uuL ws m;lk sX m;k X; xL ulsl; C DX oXX ms l;au s a(sl m oXlsl; C Df lu s X u a(sl m oXlsl; C D6 aX a(sl a;(lm uxousl(u ; u Xa;l; C D sb s l; + msl a L (a;lslk

W) b uu aoms xo;s maXx u CWc%®J a sas u uLx(ba Ls ;D lm ;o i s; nba b k masX lk masb X uu (u slmU sb X (L lm sb ( ;s L X) aX sba; am uu (u slmUsb X (L nlsblm sb ( ;s L X6 uu aoms a s u ;s ®)WJ a sas u uLx(ba Ls ; l; m ;; XL)

E) x u ;o i s l; ulUl u sa ms X sb sXl u l ;b l;3)� as (X Um ms aX moX;lmU0)� mamc blu XlmU (as msl u Cl) ) nax m nba b k b bL;s X saxL6 X (a;sc

x ma( o; u6 nbl b l; lm ; 5% L X; nlsbaos x m; ; aX6 lm x u ;o i s; nbab k m (a;scx ma( o; u aX q% L X;6 xo;s amlXx nlsb auul u slxou slmUaXxam C D m ;sX lau u k u;D6 b k asb ak Xl ; ;oXUl uuL X xak aX b koXX ms a ox ms so u ulU slamD

blu c XlmU (as msl u Cl) ) nax m nlsb om slam u ak Xl ; m ma a ox mslx( lXx ms a akl o s u aX os Xlm om slam sb s naou o; ;s XlulsLD) bl; s UaXLlm uo ; nax m nlsb aulUax maXXba C k m ; k X D6 nax m nba X ( Xlx ma( o; uaX b k io;s Uom sa x m;sXo s ) ax m a blu c XlmU (as msl u xo;s b km U slk ; Xox (X Um m L s ;s s ; X mlmU m UX ; sa am a sb auuanlmU3

9)� ax(u s ;slm m Xax lms X aoX; aX sb ( Xla Xax am; ms lmsa sb sXl uomslu E xamsb; s X sb u ;s a; a lmk ;slU slam u (Xa o s0 aX6

%)� am;l;s ms m aXX s o; a am a sb auuanlmU (s u x sba ; a lXsbamsXau aX sb ( Xla Xax am; ms lmsa sb sXl u omslu E xamsb; s X sb u ;sa; a lmk ;slU slam u (Xa o s3)� X u amsX (slk ; C lsb X ax lm aX (XaU ;s Xam amuLD)� mi s u (XaU ;s Xam)� kamaXU ;sX u lx(u ms;)� ;sXaU ml k Ulm u XlmU)� amsX (slk ( s b ;)� msX os Xlm kl C D aX lmsX os Xlm ;L;s x C D nlsb a ox ms

luoX X s a q9J ( X L XU)� u ( Xsm X ;s XlulF slam Ck ; saxL nlsb a ox ms slam a Faa;( Xxl D

(XlaX sa sb x u ;o i sh; msXL lmsa sb sXl u0 sbl; x u xo;s sb ;au( Xsm X aX sb ;o i s

b)� ao u XXl X x sba 3 am ax m m a uo;lk ( C l (bX Ux aXXkl ufk ous (;D nlsb k Ulm u ;( Xxl l u U ms

Ca xfU ufluxf X xf;o((a;lsaXLD)

3 OUGBNC KBR KB

o i s; x slmU mL a sb auuanlmU Xls Xl X CNR ulUl u m mmas mXauu lm sb sXl u39)� oXX ms kl m aX tmanm bl;saXL a ulml uuL ;lUmll ms lm slam lm uo lmU 3

)� bXaml aX amUalmU slk lm slao; l; ; X TolXlmU uamU s Xx ;L;s xl sX sx ms;o b ;6 os mas ulxls sa3 6 bXaml X m u lm slam6 bXaml b ;s lm slam nlsbXam bl s ;l;6 so X oua;l;6 aX slk b ( slsl; )

)� X klao; ; Xlao; a((aXsoml;sl aX sL(l u lm slam;))� l;saXL a (a;lslk ; XauaUL aX b ( slsl; ))� XlaX bl;saXL6 aX ;o;(l lam6 a so X oua;l; C D))� l;saXL a (a;lslk ; XauaUL aX )

%)� l;saXL a ulml uuL ;lUmll ms sX ox C )U) sX ox sl X lm lmioXL6 X X u amso;lam6;(lm u aX ax(X ;;lamD

8)� ;s aX oXX ms bl;saXL a x l uuL ;lUmll ms k X; s; Clm uo lmU uu XUl X slam;DXax3

)� aXsl a;s Xal ;)� l(b mbL X xlm)� oXlm aX xao; fbox m blx Xl msl a l ;

+) ;s aX oXX ms x ulUm m L6 w (s aX)� Xkl u X lmax s U 9 aX u ;;)� amclmk ;lk ; u uu m ;To xao; uu ;tlm X lmax)� m X l Uma; ; nlsb oX slam a ax(u s X ;(am; CX xl;;lamD 5W L X;ABGRNKr N A F RNONTB F OBTC C r 3 OU G GU L R KNF S KRB BS RBNCt

K T K O GG N K GSNCG o

W)� ;auos m osXa(blu aoms u ;; sb m 9®®®fxl Xauls X tr (u s u s aoms u ;; sb mW®6®®®fxl Xauls X a uaa )

E)� lUmll ms am oXX ms6 om amsXauu x l u am lslam lm uo lmU6 os mas ulxls sa6 X l 6X m u6 b ( sl 6 b x sauaUl u6 U ;sXalms ;slm u6 m a Xlm 6 lxxoma l l m L ;Lm Xax 6(ouxam XL6 X X u6 (;L bl sXl 6 aX m oXauaUl u l; ; nbl b aou s sb ;o i sh;; sL6 lx( lX sb ;o i sh; X ul u ( Xsl l( slam lm sb sXl u6 lx( lX sb k uo slam am (alms;6 aX m ;;ls s sb o; a x l slam mas uuan L sb (Xasa au6 ; s XxlmL sb a sb sXl u)

G)� ; a m lmk ;slU slam u XoU aX asb X w( Xlx ms u sb X (L aX am lslam asb X sb mnlsblm + n t;6 W (b Xx atlm sl b uculk ; aX oX slam a lauaUl u s

Cnbl b k X l; uamU XD (XlaX sa ; X mlmU)I)� oXX ms ( Xsl l( slam lm mL asb X lms Xk mslam u ulml u sXl u) Xsl l( slam lm mamc

lms Xk mslam u sXl u X TolX ; ((Xak u a sb (Xasa au L lmk ;slU saX)S)� o i s; nba X am oXX msuL X lklmU mL asb X lmk ;slU slam u U ms;6 aX b k

( Xsl l( s lm m lms Xk mslam u ulml u sXl u nlsblm sb u ;s %9 L;6 aX ;o i s; nba b km k lm s nlsb ulk k lm q % xamsb; (XlaX sa sXl u lm uo;lam)

9®)� o; sb X l; m omtmanm os (as msl u Xl;t aX k X; k ms; lm moX;lmU lm ms;; am XL sa sX sx ms a sb xasb X nlsb o ulsowlx X ;s lmU ;baoul; amslmo l sb xasb X l; mXauu )

x�

xo0�a X Ul;s X ;o i s6 sb auuanlmU a ox ms; ;baou ax(u s L sb X ; X b aaX lm saXm ;lUm L l b u kL6 6 b )3

•� lUm ulUl lulsL X mlmU aXt;b s•� Ul;sX slam aXx

X) kL nluu sb m k XlL ulUl lulsL) a ax(u s sb X Ul;sX slam (Xa ;;6 X) kL nluu3

•� ;;lUm ;o i s sXl u mox X•� Ul;s X sb ;o i s am sb sXl u•� s Xs sb lmo;lam a ; ( X sb (Xasa au

s X sb lX;s sna C%D ;o i s; X mXauu m ax(u s lmo;lam nlsb sXl u XoU C D aX s Xsb lX;s ;lw xamsb;6 nbl b k X l; lX;s6 sb nluu x s sa X kl n ; sL) a oXsb X ;o i s;x L mXauu lmsa sb sXl u omslu sb b ; X kl n sb ;so L s m ;o xlss sb lXam uo;lam sa sb (am;aX m ) b nluu lmaXx sb (am;aX sb s sb ;so L x L (Xa; auuan;6 sa X o sb a; 6 aX sa s Xxlm s sb ;so L o sa ; sL am Xm; ; mas uan)

Xxls; sb Xl u sa amslmo

sb ( Xxls; sb ;so L sa amslmo 6 m lslam u sbX C8D ;o i s; nluu mXauu mlmo; nlsb sXl u XoU C D) (am ax(u slam a sb lmo;lam a sXl u XoU lmsa sb ; lslam u;o i s;6 sb nluu x s U lm sa X kl n sb ; sL s Xax sb ; sbX ;o i s; m sboxou slk ; sL Xax sbl; sXl u) b nluu lmaXx sb (am;aX a mL ; sL am Xm;)

Xxlm s ; Xl u

b (am;aX C X) kLD x L b uu mU sbl; l;lam ; ( X sb b Xs X) an k X6 ma ;o i sx L mXauu lmsa sb sXl u oXlmU sb b uu mU )

J�

Jo0�lk m sb ; k XlsL m sb am; To m ; a X u (; lm 6 o; a m slk sX sx ms l; am;l X

x m saXL) b (as msl u a oXX msuL oslulF XoU; m s bmlTo ; sa X o sb lmu xx slam lmb ; m ;s ul;b (Xlx XluL sbXaoUb w( Xs am; m;o; m ;x uu a( m u u m

X sXa;( slk ;so l ;)

X sx ms nluu xlml;s X lm m lm( sl ms ba;(ls u ; sslmU m ;auos m osXa(blu aoms xo;s5 9®®®fO m (u s u s aoms xo;s 5 W®6®®®fO aX lmo;lmU )

UB OBC G NK FBCBGRK RBNC N OBRU3BF

•� I t t e i (Ir I tig o ulsowlx nluu xlml;s X ; m lmsX k mao; lmo;lam)•� as msl u XoU ms X slam;3 a XoU lms X slam; b k m X (aXs sa s )

o� r Ce I ti(g uu ;o i s; X lklmU m lmo;lam a xo;s (X cx l s((Xawlx s uL 8® xlmos ; (XlaX sa sb a; a o ulsowlx nlsb m mslbl;s xlmC l(b mbL X xlm %W c W® xU aX Tolk u msD m aX u s xlma(b m EW® xU CaXTolk u msD)

f ;o i s; nluu Ulk m m lmo;lam a +W® xUf L a ak X aoX C+D baoX;am; oslk uL am sb lX;s L nblu s sb abm; a(tlm; a;(ls u)

Jof�

a lmk ;slU slam u aX axx X l u U ms; aX sb X (l ; asb X sb m sba; ; Xl uan x Lxlml;s X nlsb sb lms ms sa sX s sb ;o i sQ; os X u (; )a ;s Xal ; x L xlml;s X aos;l a (Xasa au X TolX x ms; aX os sX sx ms ; aosulm )CUGBNC RBNCG .BRA U OBRU3BF i mo;lam X u s X slam; b k m X To msuL X (aXsnlsb o ulsowlx ) uu ;o i s; sX s nlsb o ulsowlx X TolX (X cx l slam ((Xawlx s uL 8®xlmos ; (XlaX sa sb a; a o ulsowlx nlsb m mslbl;s xlm C l(b mbL X xlm %W c W® xU aXTolk u msD m aX u s xlma(b m EW® xU) Lx(sax sl lmo;lam X slam;6 ;(ls (X cx l slam6 x L sX s s sb l; X slam a sb sX slmU (bL;l l m6 lm uo lmU os mas ulxls sa3

lslam u mslbl;s xlm ;6 awLU m m Xam ba lu saX;)

Lx(sax sl sX sx ms aX m oXa( sbl aX xo; ou X ( lm m xo; u ;( ;x; x L sX s o;lmUam axls ms x l slam ; ( X ;s m X a X )

Jop�m sb ; m a sX sx ms u L; o sa k X; k msC;D6 sX sx ms nluu Ulm am L 9 nlsbm nlsb ;s Xal ; am L 9 m amslmo sa L W6 omu ;; am a sb auuanlmU Xls Xl ((ul ;3•� u L lm sX m; X sa sb abm; a(tlm; a;(ls u Xax m aos;l lm;slsoslam) m sb k ms sb s

m ( sl ms lms X ;s lm ( Xsl l( slmU lm sb sXl u (X ; ms; nlsb m os X u (; saaos;l lm;slsoslam6 sb X ;baou ma u L lm UlmmlmU sX sx ms nlsb ;s m X a X;s Xal sb X (L) b ;o i s x L mXauu lm sbl; sXl u m X lk am a; a o ulsowlx amsb lX;s L a ba;(ls ulF slam s sb abm; a(tlm; a;(ls u l sb sX m; X s t ; (unlsblm W L; a (X ; ms slam) s Xal sX sx ms nluu amslmo s abm; a(tlm; sa m;oXsas u a W L; a ;s Xal ;)

•� ms X oXX ms luum ;; sb s (X k ms; xlml;sX slam a sX sx ms6•� m (s u k X; k msC;D oXlmU sb lmo;lam a ;s Xal ; aX 6•� o i s l ; sa nlsb X n Xax sb sXl u6 aX•� m X u aX ;( ll b mU ; lm sb ;o i sQ; am lslam X m X sb ;o i s om (s u aX

oXsb X sX sx ms lm sb io Ux ms a sb lmk ;slU saX)

b X ;am aX sXl u X xak u m sb s sb ;o i s n ; X xak xo;s a ox ms lm sb ;(aXs aXx) o i s; nba l; amslmo sb X (L o sa m k X; k ms nluu auuan omslu

X ;auoslam aX ;s lulF slam a sb k X; k ms)

Jox�s X l; b XU Xax sb ba;(ls u6 ;o i s; nluu auuan ; m aos( sl ms ulml uuL s L; S® m

9I®) m lslam6 ;o i s; nluu xamlsaX xamsbuL aX uu aoms; aX ; uamU ; ls s t ; aXuu; sa X (u s sa xlmlxox a ®)WJ aX ( sl ms; nba nluu amslmo sa sX s nlsb c uu(u slmU U ms; aX (X k mslk X 6 aX lmU sa ;s m X a X 6 aX sa xlmlxox a WJ aX

( sl ms; nba nluu o; asb X (X k mslk ;sX s Ul ;) aX xa;s ;o i s;6 sb oX slam a c uu (u slamnlsb l; o( sa S xamsb;) o i s; X xak Xax sb sXl u aX om (s u k X; k msC;D nluu

auuan omslu X ;auoslam aX ;s lulF slam a sb k X; k ms) m lslam6 ;o i s; nluub t L ax(u s uaa aoms nlsb l X msl u m ax(u s x s aul (Xalu aX kl m asawl lsL sa asb X uu; C )U)6 m osXa(blu;D aX aXU m; ;o b ; tl m L aX ulk X om slam)

V� v;lmUu a; a +W® xU a o ulsowlx nluu xlml;s X om X sb lX slam a sb Xlm l( u

mk ;slU saX6 X) l b u kL nblu sb ;o i s l; lm sb ba;(ls u) s l; X TolX sb s sb ;auosm osXa(blu aoms 5 9®®®fO m sb (u s u s aoms 5 W®6®®® O aX sb lmo;lam) sb ulk XmFLx ; C m faX D X 5 W slx ; sb o(( X ulxls a maXx u C D a sb maXx u X mU s sbabm a(tlm; x l u u aX saXL aX l sb m osXa(blu aoms m (u s u s; aoms; X uan

(s u u k u; ; ; Xl 6 sb a; a o ulsowlx nluu b u aX o( sa +I baoX; omslu sbu aX saXL k uo ; X soXm sa nlsblm (s u X mU ) uu u ; ak a mas X soXm sa nlsblm

(s u X mU nlsblm +I baoX;6 sb ;o i s nluu mas X lk sb o ulsowlx lmo;lam m nluunlsb X nm Xax sb ;so L)

P�lk m sb ; k XlsL m sb am; To m ; a X u (; lm 6 o; a m slk sX sx ms l;am;l X x m saXL) b (as msl u a oXX msuL oslulF XoU; m s bmlTo ; sa X o sblmu xx slam lm b ; m ;s ul;b (Xlx XluL sbXaoUb w( Xs am; m;o; m ;x uu a( mu u m X sXa;( slk ;so l ;)

bl; l; b ; 96 om ulm ; sL sXl u lm f ;o i s; lm nbl b ;o i s; nluu X lk amC9D lmo;lam a +W® xU a lmsX k mao; o ulsowlx s sb am; s a m w X slam lm lslamsa ;s m X a X sX sx ms nlsb luL lmsX k mao; x sbLu(X ml;auam s 9®®® xU aX lk L;)

b sXl u (b ; ; m oX slam;6 ; n uu ; ;s m X a X sX sx ms m ; X ;banm lm sbs u uan) aX sba; nba ax(u s sb sXl u6 ls l; ax(Xl; a + (as msl u (b ; ;3 X m6 s XalX sx ms6 u ;x w b mU Cl m ;; XLD X sx ms m auuanc ()

u 93 ulsowlx lm Xl u b ; ; m lxlmU; a X sx ms;f ;

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b (oX(a; a sb X mlmU b ; l; sa ;; ;; ;o i s ulUl lulsL) bl; (Xa ;; lm uo ; m; m C;s m X a X D sa l mslL amsX ;s mb m lmU u ;lamC;D lm sb a(sl m Xk m faX ;(lm uaX )

o i s; xo;s b k lX ou slmU uu; sa mXauu lm sb sXl u m X lk o ulsowlx sb X (L) aXsba; nba b k mas X lk uu (u slmU x l slam; lm sb ( ;s 9% xamsb; CXlsowlx 6a soxox 6 a X ulFox 6 o ulsowlx D6 maXx u uu aoms a Wc%®J a sas u uLx(ba Ls ; xo;s

(X ; ms lm sb lX ou slam6 amlXx L ulxls uan Lsax sXL ( m u a 86 +6 9S m%®) aX sba; nba b k X lk uu (u slmU x l slam lm sb ( ;s 9% xamsb;6 xlmlxox

a ®)WJ a sas u uLx(ba Ls ; xo;s uu;) b naXtlmU bL(asb ;l; l; sb s nb m ;o i s b ; mos ss t auuanlmU (X k mslk sb X (L nlsb uu (u slmU U ms;6 sb X x lmlmU aX X soXmlmUc uu; X k XL UUX ;;lk m x L s uLF sb ss t)R KNB K RF CR A G

lUb a; C9®®® xUD lmsX k mao; x sbLu(X ml;auam nlsb Ulk m sa uu ;o i s; nlsb camlXx slk u ;lam; s am; s a sb ss t aX lmU sa ;s m X a X ) oXlmU sb lX;s L a;s Xal sX sx ms aX ; XuL ; (a;;l u lm sb ;s Xal sX sx ms aoX; 6 +W® xU a lmsX k mao;o ulsowlx nluu xlml;s X sa uu ;o i s;)

aXs nluu a o; am UlklmU sb o ulsowlx ; XuL lm sb ;s Xal sX sx ms (Xa ;; ;(a;;l u ) ;o i sh; xl;;lam aX sX m; X sa sb abm; a(tlm; a;(ls u l; u L 6 ;s m X aX sb X (L nlsb ;s Xal ; nluu Ulm ; ;aam ; (a;;l u ) b ;o i s x L mXauu lm sbl; sXl u m

X lk o ulsowlx am sb lX;s L a ba;(ls ulF slam s sb abm; a(tlm; a;(ls u l sb sX m; Xs t ; (u nlsblm sb s Xal X sx ms b ; )XlaX sa sb lmo;lam6 ax(u s uu aoms nlsb l X msl u m ax(u s x s aul ( m u ; X mlmU

aX maXx ulsl ; lm m osXa(blu aoms6 (u s u s aoms m ulk X mFLx ;)uu ;o i s; nba lu sa ulml uuL X ;(am L L W nluu X axx m aX (u ;x w b mU ; ( X

;s m X a X ) m l l u X ;(am; l; U m X uuL am;l X m lx(Xak x ms lm sb ;( lll lsC;D sb s u sa sb ba;(ls ulF slam) ( m lmU am sba; ;( ll l ls;6 sb Xls Xl sb s X

Xaoslm uL o; s abm; a(tlm; sa lm l s sX sx ms X ;(am; C;D lm xasaX6 ; m;aXL6 osamaxlm kl;o u om slam X 3

9)� m lx(Xak x ms lm ;sX mUsb L sb asaX ; X b aom lu ;sX mUsb ; u L s u ;s 9 ouu(alms lm s u ;s sna l;au s xo; u ; a s u ;s am ulx 6 aX

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kauoms XL amsXau)+)� m lx(Xak x ms lm kl;o u olsL o;lmU ;l m uu m b Xs a V % ulm ;)

;o i s; a mas X TolX ; u slam sa (u ;x w b mU o; sb L ouluu sb ulml u Xls Xlak 6 m x L ( XaXx sa amlXx X ;auoslam a sb lmu xx saXL u ;lam6 aX lmU sa

;s m X a X s abm; a(tlm;) ; am sb m asb X ulml u saX;6 sb sX slmU(bL;l l m x L (Xa sa l; b XU sb ;o i s bax aX b mU sb (u m sa ; u slxxoma;o((X ;;lam sa (u ;x w b mU aX amslmo sX sx ms a sb os w X slam)lm lmU; L sb s x L lmuo m ; u slam sa (u ;x w b mU sL(l uuL lm uo ws m;lam amb m x ms6 lmkauk x ms a m n X ; a sb m Xkao; ;L;s x aX m lm X ; lm sb X a %bL( Xlms m;lsL) l;saXl uuL xamU sb f ;o i s; sX s s abm; a(tlm;6((Xawlx s uL W®J a f ;o i s; lx(Xak Xax X u (; nlsb ;s Xal ; uam ) basb X W®J X TolX ; u s X nlsb (u ;x w b mU )

aX l; b XU Xax sb ba;(ls u6 sb ;o i s nluu ; b ou aX auuan o( lm sb ulml lmS® m 9I® L kl;ls;) m lslam6 ;o i s; nluu ; ms sa ua u u aX xamsbuL 9S xamlsaXlmUomslu sb uu aoms; X (u s sa xlmlxox a ®)WJ aX ( sl ms; nba nluu amslmo sa sX snlsb c uu (u slmU U ms; aX (X k mslk X 6 aX lmU sa ;s m X a X 6 aX sa xlmlxox aWJ aX ( sl ms; nba nluu o; asb X (X k mslk ;sX s Ul ;) b ; X ;ous; nluu X kl n L sb 6X) kL)

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baou ;o i s; mas x s ak ulml u Xls Xl sa l; b XU bax 6 ; u slam sa sX sx ms nlsb(u ;x w b mU l; ;s m X a X )

b (u ;x w b mU sX sx ms (b ; Ulm; s sb m a sb s Xal X sx ms b ; m nluuu ;s o( sa 9+ L;) oXlmU sb u ;x w b mU X sx ms b ; 6 ;o i s; nluu om XUa 9)® r 9)Wkauox ; a (u ;x w b mU k XL asb X L aX lmU sa ;s m X a X ) s sb m a sbl; (b ; 6; am x L ( XaXx sa amlXx X ;auoslam a sb u ;lam6 aX lmU sa ;s m X a X ) mL oXsb X os lxxoma;o((X ;;lk sX sx ms aX sb os u X l; X TolX m (XaklaX lmU sa ;s m X a X 6 sb ;o i s nluu amslmo sa auuan aX ; sL l;;o ;6 os sb

ulml u l L s nluu mas lm uo lm sb ;s sl;sl u m uL;l;) l;saXl uuL xamU f

;o i s; sX s s sb abm; a(tlm; a;(ls u6 ((Xawlx s uL SWJ a f ;o i s; nbaax(u s (u ;x w b mU X l; b XU auuanlmU ax(u slam a sb (u ;x w b mU )

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b (Xlx XL aos ax l; ; sL aX sb oX slam a sb ( Xla a uu (u slam) am XL l Laos ax ; nluu ;; ;; s auuan o( S® m 9I® L; s X lmlsl u ba;(ls ulF slam aX sb osX u (; ) m lslam sa sbaXaoUb bl;saXL m (bL;l u w xlm slam6 lm uo lmU X slmU6 kl;o uw xlm slam m slx n ut6 X ; X b a sb ;(lm nluu ( XaXx s L S® sa ax( X sasb X u (; u ;lam) m lslam6 ;o i s; nluu ; ms sa ua u u aX xamsbuL 9S xamlsaXlmU omslusb uu aoms; X (u s sa xlmlxox a ®)WJ aX ( sl ms; nba nluu amslmo sa sX s nlsb cuu (u slmU U ms; aX (X k mslk X 6 aX lmU sa ;s m X a X 6 aX sa xlmlxox a WJ aX

( sl ms; nba nluu o; asb X (X k mslk ;sX s Ul ;) b ; X ;ous; nluu X kl n L sb 6 X) kL)

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aX ;o i s; nba l; amslmo aX nlsb X n Xax sb sXl u6 lmk ;slU saX; nluu amslmo sa xamlsaX;o i s; nba b k amUalmU m oXauaUl l ls; nblu sb ;o i s X x lm; lm sb ba;(ls u) bl;lmkauk ; ( Xla l m oXauaUl w x; m ua; a ; Xk slam lm auu aX slam nlsb sb sX slmU(bL;l l m)

o i s; om u sa sau X s o ulsowlx nluu nlsb X nm Xax sb sXl u) sau X lulsL l;;o aX sb(oX(a; a nlsb X nlmU sa us Xm slk sX sx ms l; lm ; xa X s aX ; k X ;l c s aXax(ul slam X u s sa sX sx ms6 nbl b l; om (s u sa sb ;o i s0 aX ulml uuL ;lUmll msb mU lm b x sauaUl 6 b ( sl 6 aX X m u u aX saXL ( X x s X; sb s6 lm sb a(lmlam a sblmk ;slU saX6 naou X TolX b mU lm sX sx ms)

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ax(u s X l; lm ; ;o i s nba b ; ax(u s uu a sb ulml uuL m ;; XL (b ; ; a sbsXl u6 ; ( X ;s m X a X 6 m b ; auuan o( lm sb ulml aX uu auuan o( kl;ls;) bx wlxox oX slam a ( Xsl l( slam l; o( sa S xamsb; aX xa;s ;o i s;)

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b sXl u nluu oslulF aX ;(lm lx UlmU nlsb m nlsbaos amsX ;s oXlmU sb sXl u aX X u (; ;6; ( X ;s m X a X m aX X ; X b (oX(a; ; am S®c L auuanco() m ; ; a (aaX X slmlmu X m 6 amsX ;s nluu mas o; ) aX lmU sa ;s m X a X 6 ; m; lm sb sXl u nluu( XaXx s sb lmlsl slam a sb X u (; ) m auuan o(6 sb l; X ; X b (Xa oX )aX (oX(a; ; a sbl; sXl u6 ;s m X a X ; a sb ;(lm nluu X kl n L sXl u ;s 0 sb

auuanlmU b X s Xl;sl ; nluu X aX aX X ; X b (oX(a; ;3

9)� mUsb a ; Ulss u ;(lm % u ;lam lm mslx s X; lm uu ;o i s; nba a s lm ;6 m%)� mUsb a ; Ulss u ;(lm 9c(a;s amsX ;s u ;lam lm mslx s X; m faX aX ls u 9c(a;s

amsX ;s u ;lam lm xluulx s X; lm sba; ;o i s; nba lslam uuL X lk U aulmloxamsX ;s)

;lmUu ulm m ( m ms X nluu X kl n sb aX X ; X b (oX(a; ;) b X X nluuulm sa sb sX sx ms ;;lUmx ms; m slx ; To m ; a sb ; m;)

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t t I ti3 XU s; %® mslU m am c uu;

( r hI tig ulsowlx l; U m sl uuL mUlm X blx Xl xoXlm fbox mlX s U lm;s sb %® mslU m aom am sb ;oX a

uLx(ba Ls ;) ulsowlx l;(u L; sb sL(l u ;sXo soX alxxomaUua oulm;6 am;l;slmU a sna U xx CγD b kL b lm; m snat (( CκD ulUbs b lm; ulmt L l;oul Xl U ;) s l; ax(a; axoXlm k Xl u X Ulam C8G)%J a sas u xlma l ;D o; amsa box mam;s ms X Ulam;)

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s x( X soX X mUlmU H%1 f H I1 ) ulsowlx xo;s mas XaF m)

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o; lxx l s uL) s X luoslam lm (auLklmLu buaXl C D lmo;lamU;6 o ulsowlx l; ;s u lm ;s sl am lslam; aX %+ baoX; s %W1 6 m

lm Lm xl am lslam; ls l; ;s u aX I baoX; s %W1 )

ulsowlx b ; ;b ucul a 9I xamsb; ; am k lu u ;s lulsLs )

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b omls aw ; ams lmlmU sb 8 x kl u X UXao( L W lm aos X( t U aw ;6 nbl b nluu (Xakl sa sb ulml u sXl u ;ls ;) b omlsaw ; ams lmlmU sb 9W x kl u X mas UXao( lm aos X ( t U aw ;m sb L nluu (Xakl lm lkl o uuL sa sb ulml u sXl u ;ls ;)

b ams lm X ua;oX ;L;s x a o ulsowlx l; L( Uu ;; kl u ua;L ;lul amlF Xaxa osLu Xo X ;sa(( X m s x( X(Xaa

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X b lsl;6 XLmUlsl;6 am;luulsl;6 Xaslsl;6 slsl; x l 6 Xlm XL sX s lm slam6 m u; ;;6 Xam ba(ouxam XL ;( XUluua;l;6 Xlu lm slam6 l;s Xla;l;6 (sl ;ba t6

s (bLua a u ; (;l;6 sX (sa a u ; (;l;6 ( slsl; 6 mls u b X( ;6 X( ; Fa;s X6•� CLUKrt SNBGNCBCT C SKN UK O NFSOB RBNCGi XamU s bmlTo lm XoU o; U

(Xa ;;6 lmioXL6 a;sa( X slk b Xml 6 o os m ao; b x sax•� CD GRBT RBNCGi lUbs X ; 6 Xox U lm X ; 6 % ; soX slam X ;•� R NOBGF C CURKBRBNC BGNK KGi l s ; x uulso; lm To s amsXau6

L( X bau ;s Xau xl 6 L( XUuL xl 6 L( XoXl xl•� UG UONGE O R O C NCC RBD RBGGU BGNK KGi t ( lm6 o; oua;t u s u ( lm6

o; u ;( ;x;6 L uUl 6 XsbX uUl 6 m amlsl;•� NSO GFG CBTCt F OBTC CR C UCGS BB gBC O rGRG C SNOrSG4i To xao; uu

X lmax 6 ; u uu X lmax 6 ot xl 6 oXa m a Xlm X lmax a sb ;tlm•� KDNUG GrGR F BGNK KGi axmau m 6 X ;sb ;l 6 Lm a( k ;ak U u6 ; b xl ;sXat•� Gr AB RKB BGNK KGi mwl sL6 UUX ;;lam6 (X ;;lam6 m;axml•� C O C UKBC Kr BGNK KGi x soXl

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Xam ba(m oxa( sbL•� EBC C GU UR C NUG RBGGU BGNK KGi XLsb x 6 Xsl Xl 6 uu XUl Xx slsl;6

Xlk ; ou X Xx slsl;6 tlm b xaXXb U 6 L( Xbl Xa;l;6 lUbs ;n s;•� G UO K BGNK KGi L( Xs m;lam6 L(as m;lam6 as uo;b

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sL s aX o ulsowlx l; amuL k lu u Xax xlml;sX slam lm 88 ( sl ms; lm sb X msuLax(u s b ; ulml u sXl u lm X u (; m X X saXL ) ; ;o b6 o sa ;s sl;sl uulxls slam;6 ma om axxam k X; k ms; Ca oXXlmU lm V®)9J m q9J a ( sl ms;D m

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m sb ulml u sXl u ;ls X lk ; f ((Xak u m ((Xak u ; m mk ;slU saXc mlsl sC (am;aXD (X c s Xxlm To mslsL a sXl u XoU C D nluu ;bl(( Xax b X ( osl ;sa sb mk ;slU slam u b Xx L s abm a(tlm;)

(am X l(s a sX sx ms ;o((ul ;6 sb b Xx l;s aX sb ((Xa(Xl s ( X;am a sb ;ls nluuax(u s sb tmanu U x ms a X l(s m ; m ls t sa sb b X ( osl ; aX ;lUm mo( s sb aoms lulsL aXx; aX b X ( osl ;)

mL maXx ulsL am sb ;o((ul aw ; l; a ; Xk 6 sb b Xx l;s aX sb ((Xa(Xl s ( X;amxo;s a ox ms sb s am sb tmanu U x ms a X l(s aX ; m lmU ls sa b X ( osl ; aX ls;

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b X l; ma X m axlF slam lm sbl; om ulm 6 a( mcu u ; sL ;so L)yofoV� BGS CGBCT

aX l;( m;lmU6 sb ;ls (b Xx l;s aX bl;fb X X (X ; ms slk xo;s b t sb s o ulsowlx l; lmaX m nlsb sb (Xa o s ;( ll slam; m sb k ul lsL l; nlsblm sb X cs ;s m w(lXL s )

b w s a; m sb s m slx a xlml;sX slam a o ulsowlx xo;s X aX nlsblm sb6 ;o i sh; x l u X aX ;6 m faX lm sb XoU aoms lulsL X aX ;) s b mox X; a

o ulsowlx xo;s X (aXs nlsblm sb )

b b Xx l;s aX bl;fb X X (X ; ms slk nluu X aX sb s l;( m; m ;o i sh; mox X mlmlsl u; am sb u u;) f;b nluu ax(u s sb aoms lulsL aXx; nlsb lmaXx slam am XmlmUsb l;( m; slam a o ulsowlx ) X ( X slam nluu am L sb b Xx l;s aX bl;fb XX (X ; ms slk aX lmU sa lm;sXo slam; aX ;s Xlu luoslam lm uo nlsblm sb omls aw ; ao ulsowlx ) luoslam aX o ulsowlx l; ; auuan;3

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ulsowlx xo;s mas xlw nlsb asb X x l lm u (Xa o s;) ulsowlx ;baou amuL luoslm ®)SJ u aX o; ) a s X k lu u aX asb X ;auoslam; ;o b ; WJ wsXa; m WJx mmlsau)

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aX (a;ls;)•� ulsowlx xo;s mas xlml;s X l a ; mas amaXx sa sb ;( ll slam;) b

mk ;slU saX aX bl;fb X X (X ; ms slk xo;s lxx l s uL lmaXx b X ( osl ;)•� m aX m nlsb slam W)9c ul;s a (X cx l slam nluu xlml;s X aX lmo;lam

a o ulsowlx )•� lm lmo;lamcX u s bL(as m;lam x L a oX6 CRBArS KR CGBD F B RBNCG F r

.BRAA O %+ baoX; (XlaX sa m sbXaoUbaos lmo;lam a o ulsowlx•� a asb X sX sx ms x L ac xlml;s X nlsb o ulsowlx Casb X sb m aX lxx l s

lms Xk mslam aX k X; k msD)•� s l; X axx m sb s o ulsowlx xlml;s X lxx l s uL s X luoslam)

ulsowlx ;baou xlml;s X amuL L ;uan lmo;lam kl lmsX k mao; Xaos ; ;lmUuxlml;sX slam ak X aoX C+D baoX;)

b uan X s l; ;( ll lm sb s u ; uan)yofoPo0� ON. R NK

•� ® sa 8®Q3 %J a sb sas u kauox•� 8®Q sa 9 3 +J a sb sas u kauox•� 9 sa % 3 9+J a sb sas u kauox•� %b sa + 3 I®J a sb sas u kauox

CUGBNC K R N U OBRU3BF

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NR O DNOUFRN BCUG

CUGBNC K Rh RNph2 phc RN 0 0 RN f f RN x

+W® xU %W® x 9® x f %® x f 8W x f 9®® x f

yofoy� T CR rS KG CGBRBDBRr

OBRU3BF rS KG CGBRBDBRr C CUGBNC RBNCGg k lu u s sb ;l (XlaX sao ulsowlx xlml;sX slam nluu (lm (bXlm aX ;o os m ao; lmi slam6 l(b mbL X xlmbL Xa buaXl aX lmi slam6 m X ;o; ls slam Tol(x ms aX sb x XU m L x m U x ms a

m (bLu sl X slam;) ulsowlx ;baou xlml;s X lmsX k mao;uL sbXaoUb l sulm )

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sicgctoyPoc1g 1:oyePoiego

6eLotA/f ts /7gf,-8 /tfL ts /7g to 7f L7oig7f rtffATiL As e:Af r:7fL

g:1yies 1gtego 8nc chcncol 8ei1 yPdSca PgsescaPn cto1yl 8 8 8

yc1y oyePoiegot 8coPn tc gt *ec So 8 8 8 8 8 8 8 8 8eTy1n1 caPn 5Pi 8 8 8 8 8 8 8 8 8Ph1yPo1yl Pttettiego 8 8 8 8 8 8 8 8

8 8 8 8 88 8 8 8 8

cies 11o Pnr 8 8 8 8 8smeyte megot 8 8 8 8 8 8 8 81ga1icoPgo est 8 8 8 8 8 8 8

0h�bl; l; (Xlx XL ; sL ;so L6 os n X lms X ;s lm X aX lmU (as msl u x ;oX ; a l L)b ; nluu ;; ;; ; ; am XL ulml u m (alms;) Xlx XL aos ax x ;oX ; aX ; sL Xs lu lm ; slam 9% uan)

B r C SNBCRGulml u aos ax ; nluu xamlsaX aX l L o;lmU sbX om slam u m oXauaUl s ;s;6 sbw( m l; lulsL s so; u C D6 lx %Wc aas ut m lUb amsX ;s l;o u olsL

C D) b ; nluu ;; ;; L; 9 m W a ba;(ls ulF slam m n tuL sb X s X aX sb lX;ssbX n t; C L; 98 m %® oXlmU ( Xla ; m D) m lslam6 n nluu o; To msll u

( X x s X; ; ; am XL m (alms ; ; Xl uan)

b oXsFt w( m l; lulsL s so; u C D n ; k ua( sa x ;oX sb l; lulsL;s so; a ;o i s; nlsb xousl(u ; u Xa;l;) s uuan; m a i slk To msll slam a sb u k u aom slamlmU sb s aou nl uL m X (Xa o l uL o; L X ; X b X; m b usb X (Xakl X;)b (Xakl ; sas u ; aX am ; u sb s X mU ; Xax ® sa 9®) b lX;s u k u; 9)® sa +)W X X

sa ( a(u nlsb blUb UX a x ou saXL lulsL m sb ;o ; To ms u k u; W)® sa S)W X X sa sbua;; a x ou saXL lulsL) b X mU a x lm s UaXl ; lm uo C®D / maXx u m oXauaUl w x0 saCWD / x ou saXL nlsbaos l aX X ;s aX %®® x s X;0 l; lulsL ; k X maoUb sa lx( lX ouu luLslklsl ;0 sa C9®D / sb o sa ) m lslam6 ls u;a (Xakl ; lUbs ;o ; u x ;oX x ms;uu om slam u L;s x C D ; aX ;) b ; ;o ; u s UaXl ; X ul;s lm (( m lw %)

lUb amsX ;s l;o u olsL3 lUbc amsX ;s ua m u ss X b Xs; X X luL k lu u m (Xakl(X sl u6 To msls slk 6 m ;s m X lF ;; ;;x ms a kl;o u om slam) b b Xs am;l;s; a Xan;a u t u ss X; C X ;lmU lm ;lF Xax sa( sa assaxD am nbls tUXaom )

aX sbl; sXl u6 9®®Jxama ou X blUb amsX ;s kl;o u olsL nluu x ;oX am L; 9 m W oXlmUsb ;s Xal (b ; m n tuL oXlmU sb (u ;x w b mU (b ; ) b Xs; nluu X s %cx s Xl;s m L sX lm w xlm X; lm sb ba;(ls u Xaax nlsb am;s ms ulUbslmU a I®c9®® aasc m u ;ax(ul;b o;lmU ;s m X uoaX ; ms ba;(ls u Xaax ak Xb ulUbslmU) lma ou X s ;slmU nluu

X aX ; sas u mox X a u ss X; l msll aXX suL Cx wlxox E®D)

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lx %Wcaas n utlmU sXl u; nluu ;; ;; am L; 9 m W oXlmU sb ;s Xal (b ; m n tuLlm sb (u ;x w b mU (b ; ) b lx %Wc aas ut s ;s l; To msls slk x ;oX a uan XwsX xlsL om slam) X TolX 6 sb ;o i s x L o; m ((Xa(Xl s ;;l;slk kl sa n ut ;Tol tuL ; b f;b m Xax am m sa sb asb X m a u XuL x Xt 6 oma ;sXo s 6 %WcaasaoX; ) k XL aXs nluu x sa o; sb ; x s ;slmU b uun L aX k XL lx %Wc aas uts ;s) as msl u aX ws Xm u l;sX slam; ;baou t (s sa xlmlxox ; xo b ; (a;;l u ) ;o i snluu ;s m nlsb sb sa ; a bl;fb X ;ba ; am sb ;s XslmU ulm Cl msll L s ( x Xt am sbuaaXD m slxlmU nluu Ulm nb m mL ( Xs a sb ;o i sQ; aas Xa;; ; sb s ( ) lxlmU nluu mnb m mL ( Xs a sb ;o i sQ; aas Xa;; ; sb lml;b ulm Cl msll L s ( x Xt am sb uaaXD)lx nluu X aX lm ; am ; m Xaom sa sb m X ;s s msb a ; am o;lmU ;sa(n s b

(Xakl aX sbl; sXl u) b s ;t l; lxx l s uL xlml;s X U lm L b klmU sb ;o i s n ut tsb ; x l;s m ) b k X U a sb sna k uo ; nluu X aX lm sb ; X (aXs aXx)

L RBD B r C SNBCRG

; nluu ( XaXx aX ;s m X a X m X ; X b (oX(a; ; m nluu o; sa x tulml u l;lam; aos ; u slam a lxxoma;o((X ;;lk sX sx ms) aX sbl; sXl u6 sb ; nluuu;a m uLF aX sna ( X x s X;3 u mUsb m % bL( Xlms m;lsL lm sb ;(lm u aX m a(slm Xk m u mUsb a 9 (a;sc amsX ;s mb m x ms l k lu u )

ox X a L; lm sb ba;(ls u m X TolX x ms aX (u ;x w b mU nluu u;a X aX am sb;)

0ho0�CR CRlRNl K Ro uu ;o i s; nba X lk am a; a sXl u XoU nluu lm uo lm sb lms mscsacsX s UXao()

Kl KNRN NOo uu ;o i s; nba ( XaXx uu kl;ls; lm aX m nlsb (Xasa au nlsbaos ;lUmll ms(Xasa au kl slam; aX klau slam;)

OO U L R K RF CR KNUSo uu ;o i s; nba X lk am a; a sXl u XoU C D)

00�bl; ; slam ; Xl ; sb ;s sl;sl u x sba ; sa o; sa m uLF sb l L m ; sLm (alms;) aXx u ;s sl;sl u m uL;l; (u m C D6 nbl b xo;s lm ulF aX s ; ua t6nluu (Xakl lslam u s lu; aX s b m ulmU (Xa oX ;6 ;s sl;sl u x sba ;6 m s(X ; ms slam; C )U)6 s u 6 ul;slmU6 m lUoX ;b uu;D) b lm u ulml u ;so L X (aXs nluu ; Xl

kl slam; Xax sb 6 l mL)

00o0�rSNRA GBGbl; sXl u l; w(uaXlmU sb ; sL a o ulsowlx lm sb sX sx ms a f X u (; ;) b

bL(asb ;l; l; sb s sb o ulsowlx X Ulx m (Xa(a; lm sbl; sXl u l; ; m sau X u lm sbf ( sl ms (a(ou slam) b a i slk ; a sb sXl u nluu ;; ;; sbXaoUb sb o; a

;oxx XL ;s sl;sl ;)

FSO Ba NCGB K RBNCGb ; x(u ;lF a W ;o i s; l; ; am ;l lulsL m uaUl;sl u am;l X slam; am sb mox X a

;o i s; sb s nluu X k u ;lUmll ms Xl;t aX sau X lulsL l;;o a o;lmU o ulsowlx H ;s Xal ;) s l;msl l( s sb s 9 ;o i s nluu lu ; X mlmU m 9 nluu Xa( aos ak X sb aoX; a sb sXl u6 aXsas u a + ;o i s; nba X w( s sa ax(u s sb sXl u) o i s; nba nlsb X n nluu masX (u )

00of�CR KBF C OrGBG

b X nluu ma lms Xlx m uL;l;)

R RBGRB O C OrGBG

;oxx XL a sb mox X m ( X ms U a ;o i s; nlsb mL k X; k ms6 mL ; Xlao; k X;k ms6 k X; k ms; u lmU sa ( Xx m ms l; amslmo slam a sXl u XoU6 m sXl u XoUcX u sk X; k ms; nluu X (aXs )

b mU lm m oXauaUl aos ax ; am sb 6 lx %Wc aas ut m ; u ; Xax xl;;lamsa l; b XU nluu m uLF L ( lX scs ;s; nlsb ;lUmll ms (ck uo ; am;l X u ;; sb m ®)®W)

L 6 u mUsb a % bL( Xlms m;lsL m u mUsb a 9c(a;s amsX ;s mb m x ms ;baou ;s uaX X o L l; b XU ) ( lX scs ;s nluu o; sa ax( X b mU ; lm sb ; k uo ; nlsb;lUmll m am;l X s (ck uo ; u ;; sb m ®)®W)

amslmoao; s nluu ; Xl o;lmU sb auuanlmU ; Xl(slk ;s sl;sl ;3 m6 x m6 x l m6xlmlxox m x wlxox) s nluu l;(u L lm uu ul;slmU; ;aXs L ;o i s mox X)

b m aoms s X (X ; ms 6 sb ( X ms U nluu ;o((X ;; nb m sb aoms l; F Xa lm aX Xsa X n ss mslam sa sb mamcF Xa aoms;) Xan mas p l;;lmUe nluu lm uo lm aomss ou slam; nb X m ;; XL sa aoms aX Xa(aos; m xl;;lmU k uo ;) mu ;; asb Xnl;;( ll 6 sb maxlm saX aX ( X ms U ; nluu sb mox X a ;o i s; nlsb mamcxl;;lmU;; ;;x ms nlsblm sb m uL;l; (a(ou slam a lms X ;s)

X;lam S)% nluu o; sa ( XaXx uu m uL; ;)

00op�b ms mscsac X s C D (a(ou slam nluu o; aX sb al l u m uL;l;)

b sL a(ou slam nluu lm uo uu ;o i s; nba X lk am a; a sXl u XoU C D) uu ; sL;; ;;x ms; lm uo lmU sawl lsL nluu ( XaXx am sb sL a(ou slam)

b Xc Xasa au a(ou slam C D nluu am;l;s a uu ;o i s; nlsbaos x iaX (Xasa au kl slamaX (Xasa au klau slam) b Xls Xl aX x iaX (Xasa au kl slam aX klau slam nluu s Xxlm ma ox ms (XlaX sa s ; ua t) o i s w uo;lam Xax sb (a(ou slam nluu u;as Xxlm m a ox ms (XlaX sa s ; ua t) o((aXslk m uL; ; x L ( XaXx ;

am sb (a(ou slam)

00ox�b l;(a;lslam a ;o i s; lm uo ; sb mox X m ( X ms U a ;o i s; aX sb auuanlmUs UaXl ;3 ;o i s; sX s C; sL (a(ou slamD6 ;o i s; lm sb (a(ou slam6 ;o i s; ax(u s 6m ;o i s; l; amslmo Xax sb sXl u) uu ( X ms U ; nluu ; am sb mox X a ;o i s;mXauu ) b X ;am; aX sXl u l; amslmo slam nluu u;a ;oxx XlF lm sbl; s u ) muL amX ;am aX sXl u l; amslmo slam nluu X aX ) an k X6 uu X ;am; nluu (X ; ms lm sbul;slmU)

ul;slmU nluu (X ; ms s am XmlmU ;o i s l;(a;lslam)

00oJ�; ulm xaUX (bl m ulml u b X s Xl;sl ; nluu ;oxx XlF ; ( X ms U ; aX s UaXl u

k Xl u ; m ; x m6 ;s m X kl slam6 x l m6 xlmlxox m x wlxox aX amslmoao;x ;oX ;) b m uL; ; a ; ulm b X s Xl;sl ; nluu ( XaXx aX sb a(ou slam)

00oV�XlaX m am axls ms x l slam; nluu ;oxx XlF aX sb sL (a(ou slam L aXu usbXU mlF slam C D m l slam XL) o i s; x L b k xaX sb m am x l slam ( XXoU u ;; m (X XX s Xx) s b u k u a ;oxx XlF slam6 ;o i s l; aoms am l b f;b

X (aXs am aX xaX x l slam; s sb s u k u)

XlaX x l slam; X lm ; x l slam; nlsb ;sa( s a oXXlmU aX sb s a X lklmUlX;s sXl u sX sx ms) am axls ms x l slam; X lm ; x l slam; nlsb ;s Xs s ;a oXXlmU am aX s X s a X lklmU lX;s sXl u sX sx ms) l slam; nlsb ;s Xs m ;sa( s ;nbl b X t s sb s a lX;s a; nluu ;oxx XlF ; asb (XlaX m am axls ms x l slam;)

00oP�l u bl;saXL nluu (soX s sb X mlmU kl;ls) l u bl;saXL nluu a o;lmU

m nluu ;oxx XlF L ;L;s x aXU m u ;; m (X XX s Xx aX sb sL(a(ou slam)

00oy�b a; CxUD a sXl u XoU xlml;s X C D6 m sb oX slam a sX sx ms nluu ;oxx XlF

nlsb ; Xl(slk ;s sl;sl ;) b (Xa(aXslam a ;o i s; ax(u slmU sb lmo;lam a sXl u XoU C Dnluu ;oxx XlF )

00ob�am XL m (alms; a ulml u aos ax ; nluu xamlsaX aX l L o;lmU sbX om slam u

m oXauaUl s ;s;6 sb w( m l; lulsL s so; u C D6 lx %Wc aas ut m lUbamsX ;s l;o u olsL C D) b ; nluu ;; ;; L; 9 m W a ba;(ls ulF slam m n tuL

sb X s X aX sb lX;s sbX n t; C L; 98 m %®6 l m D) b (Xlx XL m uL;l; nluub mU Xax ; ulm sa L S® m sb ; am XL m uL; ; nluu b mU Xax ; ulm sa L;W6 %®6 m E xamsb;)

aX sbl; ; am XL l L m (alms6 sb ; nluu m uLF aX sna ( X x s X;3 u mUsb a %bL( Xlms m;lsL lm sb ;(lm u aX m a(sl m Xk m u mUsb a 9 (a;sc amsX ;s mb m x ms lk lu u ) b ; am XL m uL; ; aX nluu b mU Xax ; ulm sa l; b XU am L W aX%®6 ; n uu ; b mU Xax ; ulm sa auuan o( s L S®)

ox X a L; lm sb ba;(ls u m X TolX x ms aX (u ;x w b mU nluu ;; ;; o;lmU; Xl(slk ;s sl;sl ;)

0f�

0fo0� sL k uo slam; nluu ; am sb lm l m 6 lms m;lsL6 m sL( a k X; k ms;6 ; n uu ;

am ulml uuL ;lUmll ms b mU ; lm sb ;o i sh; (bL;l u w xlm slam6 kls u ;lUm;6 m ulml uu aX saXL X ;ous;) sL m uL; ; nluu ( XaXx o;lmU sb ; sL (a(ou slam) sL k Xl u ;nluu s ou s m (X ; ms ) w(a;oX sa sXl u sX sx ms m X ;am; aX l; amslmo slam asXl u sX sx ms nluu u;a s ou s )

0fof�k X; k ms C D xamlsaXlmU m X (aXslmU l; Xaoslm ( Xs a k XL ulml u sXl u) b auuanlmU

ul;s a ; m sb b X s Xl;sl ; a m a ; Xk C slam I)%D nluu s Xxlm nb sb X sb k msX TolX ; w( ls X (aXslmU lm lslam sa Xaoslm X (aXslmU)

0fop�R KF g G KBSRBNC4 C TK i b ; Xl(slam; m UX lmU ; u ; aom lm sb

X kl; axxam XxlmauaUL Xls Xl aX k X; k ms; C D k X;lam +)® nluu oslulFaX X (aXslmU) uu ((Xa(Xl s sX sx ms X ; ;baou b k ;; sa a(L a sbk X;lam +)®) a(L a sb k X;lam +)® m anmua Xax sb n ;lsbss(3ff s () m X)Uakf(Xasa au k ua(x msf u sXaml A ((ul slam;f s )bsx)

e 3S R C GG2i ; m y m w( s h aX y w( s h aX w( ls X (aXslmU (oX(a; ; amuL)

0fox� l

b X X ma w uo;lam; aX w( ls k X; k ms X (aXslmU) uu k X; k ms;6 lm uo lmU sb6nluu am;l X om w( s m ;o i s sa w( ls X (aXslmU)

0foJ�uu ; m ; a oXXlmU am sXl u nluu ul;s L ;o i s) b X To m L m ( X ms U ; a

;o i s; nlsb sX sx msc x XU ms k X; k ms; C ;D nluu s ou s L ;L;s x aXU m u ;;C D m 6 nb X sX sx msc x XU ms l; lm ; mL sb s3

•� oX; s X lX;s a;lmU a sXl u x l slam m sbXaoUb sb m a sb sXl u aX o( sbXaoUb8® L; s X sb u ;s a; a sXl u sX sx ms6 aX

•� ; am;l X sX sx mscX u s X U X u ;; a sb ;s Xs s a sb k ms6 aX•� ; (X ; ms aX lX;s a;lmU a sXl u x l slam os naX; m; lm lms m;lsL aX sb lmk ;slU saX

;o ; To msuL am;l X; sX sx mscX u s )

; sb s X am;l X s u ;s (a;;l uL X u s sa sXl u sX sx ms nluu s ou s ; n uu ;sb;6 ;6 m k ms; X ;ouslmU lm sX sx ms l; amslmo slam)

; sb s a oX s X lmaXx am; ms os aX lX;s a;lmU a sXl u x l slam nluu mas;oxx XlF os nluu ul;s )

s b u k u a ;oxx XlF slam6 ;o i s nluu aoms amuL am aX b 6 6 aXw( Xl m nlsblm sb s u k u) m sb ;oxx slam aX ; k XlsL6 nlsblm b u k u a 6 6 aXw( Xl m 6 sb am nlsb sb blUb ;s ; k XlsL nluu lm uo ) m sb ;oxx slam aX h;

X u slam;bl( sa sb sXl u XoU6 nlsblm b u k u a 6 6 aX w( Xl m 6 sb am nlsb sbua; ;s X u slam;bl( sa sb sXl u XoU nluu lm uo )

0foV�m k X; k ms C D l; mL omsan X x l u a oXX m lm ;o i s aX ulml u lmk ;slU slam

;o i s xlml;s X (b Xx osl u (Xa o s) m a ; mas m ;; XluL b k sa b k o; uX u slam;bl( nlsb sbl; sX sx ms) m k X; k ms C D m sb X aX mL om kaX u momlms m ;lUm Clm uo lmU m maXx u u aX saXL lm lmU6 aX w x(u D6 ;Lx(sax6 aX l; ;s x(aX XluL ;;a l s nlsb sb o; a x l lm u (Xa o s6 nb sb X aX mas am;l X X u s sasb x l lm u (Xa o s) bl; lm uo ; mL a oXX m sb s l; m n lm am; s aX UUX k s lm ; k XlsLaX X To m L Xax sb ; ulm am lslam)

m ulml u ;so l ;6 m m lm uo m om ;lX u x l u am lslam a oXXlmU s mL slx 6lm uo lmU Xomclm aX n ;baos ( Xla ;6 k m l ma sXl u sX sx ms b ; m xlml;s X ) baxxam XxlmauaUL Xls Xl aX k X; k ms; C D k+)® l; sa o; aX sb UX lmU a

; k XlsL a ;Lx(sax; m maXx u lm lmU;) aX k X; k ms; mas ak X L sb cX;lam +)® UX lmU ;L;s x6 sb auuanlmU lmlslam; nluu o; 3

•� K 03 lu 0 ;Lx(sax sl aX xlu ;Lx(sax;0 ulml u aX l Uma;sl a ; Xk slam; amuL0lms Xk mslam mas lm l s )

•� K fi a X s 0 xlmlx u6 ua u aX mamclmk ;lk lms Xk mslam lm l s 0 ulxlslmU U c((Xa(Xl s lm;sXox ms u ,)

•� K p3 k X aX x l uuL ;lUmll ms os mas lxx l s uL ul csbX s mlmU0ba;(ls ulF slam aX (XauamU slam a ba;(ls ulF slam lm l s 0 l; ulmU0 ulxlslmU ; uc X

,,•� K x3 l csbX s mlmU am; To m ;0 oXU ms lms Xk mslam lm l s )•� K J3 sb X u s sa )

b mk ;slU saX xo;s u;a ;; ;; sb X u slam;bl( a mL k X; k ms sa sb o; a sXl u XoU6; am k lu u lmaXx slam6 o;lmU sb auuanlmU Uol ulm ;3

•� NR O R 3 u Xc os s x(aX u m faX x b ml;sl X u slam sa o; asb X sb m sb sXl uXoU)

•� NU RUO3 b X l; ma X ;am u (a;;l lulsL sb s sb k ms l; X u s sa sb sXl u XoU oslmls o; mmas ; Xs lm )

•� NGGB O 3 b X l; ;sluu X ;am u (a;;l lulsL sb s sb o; a sb k ms n ; sb sXl u XoUos sb X wl;s; xaX ult uL o; a sb k ms ;o b ; ax(ul slam; a (XaUX ;;lkl; ; )

•� KN O 3 b xa;s ult uL o; a sb k ms l; sb sXl u XoU os asb X o; ; mmasax(u s uL w uo )

•� BCBR i u X os s x(aX u m faX x b ml;sl X u slam sa sb sXl u XoU) uu asb X o; ;b k m ulxlm s ) k ms; u ;;ll ; lmls nluu as m amlXx L a ox mslmUX ;auoslam am l; amslmo slam a sb sXl u XoU m X oXX m o(am X ;ox(slam)

0foVo0� NK BCT N D KG D CRG

uu k X; k ms; a mL ;o i s oXlmU sb aoX; a sb sXl u nluu X (aXs am sb ; X (aXsaXx6 m sb lmk ;slU saX nluu Ulk bl; aX b X a(lmlam ; sa sb X u slam;bl( a sb k X; k ms sasXl u XoU sX sx ms Cl) )6 nb sb X sb k ms l; X u s aX omX u s sa sXl u XoU xlml;sX slamD) sb k X; k ms l; ; Xlao;6 ls ;baou X (aXs ; ;aam ; (a;;l u m ma UX s X sb m %+ baoX;

sa b X ( osl ; m sb b lX a ) b abm; a(tlm; xo;s u;a masll ;X TolX L abm; a(tlm; Uol ulm ;) sb X omsan X k ms; a oXXlmU lm sb X x naXt aulml u sXl u X u;a sa X aX ; ; Cl) )6 ; sb s a oX (XlaX sa ;;lUmx ms a sXl usX sx ms sb s X X u s sa (Xasa aucx m s lms Xk mslam6 lm uo lmU lmk ;lk (Xa oX ; ;o b; la(;l ;6 x l slam n ;baos6 aX ma sX sx ms XomclmD)

uu ; X U X u ;; a ; Xlao;m ;; aX X u slam;bl( sa o ulsowlx sX sx ms ;( mmlmU Xax sb;lUm soX a sb lmaXx am; ms aXx6 omslu 8® u m X L; s X l; amslmo slam aX ax(u slama (Xasa auc;( ll sX sx ms ; lm L sb (Xasa au aX sb s ;o i s6 X sa X aX am sb

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b X (aXslmU a maXx ulsl ; a kls u ;lUm; ; k X; k ms; ;baou kal ) maXx ulsl ; akls u ;lUm; ;baou mas X (aXs omu ;; mL Xls Xlam aX m l; ouluu 6 sb kls u ;lUm;

maXx ulsl ; o; sb ;o i s sa l; amslmo sXl u sX sx ms6 aX sb lmk ;slU saX lm;l;s; sb s sbmaXx ulsL ;baou X (aXs ; m ) mL UX 8 aX + u aX saXL maXx ulsL aX mL ulml uuL

;lUmll ms UX 9 aX % b x sauaUL aX la b xl;sXL u aX saXL k uo C;D ;baou X aX ; m) m maXx u u aX saXL k uo aX kls u ;lUm l; ;;a l s nlsb ulml u ;lUm; m faX ;Lx(sax;6

sb ;lUm aX ;Lx(sax ;baou X (aXs ; m 6 m sb ;;a l s u aX saXL k uo aX kls u ;lUm;baou am;l X lslam u lmaXx slam sb s xo;s auu s am sb X u k ms )

ulml u aX saXL ;ous; nluu ;oxx XlF ) oxx XL ;s sl;sl ; aX so u k uo ; m aXb mU ; Xax ; ulm nluu s ou s aX u aX saXL X ;ous; L ; b ou kl;ls) o i s; nlsbu aX saXL k uo ; aos;l a sb maXx u X X m X mU s mL (a;sc ; ulm ;; ;;x ms nluu;oxx XlF 6 m UX ( X X;lam +)® nb m ((ul u ) o i s lm l m au aX saXL sawl lsL nluu ;oxx XlF m ;;lUm x wlxox UX aX b u aX saXL s ;s)0foVop� C OBCT N D KG D CRG

uu k X; k ms; X ;ouslmU lm l; amslmo slam Xax sb sXl u ;baou auuan omslu X ;auoslam aX;s lulF slam) o i s; xo;s auuan aX ; aX 8® u m X L; s X l; amslmo slam aXax(u slam a (Xasa auc;( ll sX sx ms) uu m n ; a oXXlmU oXlmU sbl; ( Xla xo;sX (aXs m auuan omslu X ;auoslam omu ;;6 lm sb a(lmlam a sb lmk ;slU saX6 sb ; k uo ; Xmas ult uL sa lx(Xak o; a sb om XuLlmU l; ; ) m sbl; ; 6 sb lmk ;slU saX; xo;s X aXbl; aX b X X ;amlmU aX sbl; l;lam lm sb ;o i sh; x l u X aX m ; axx ms am sb )s X 8® L;6 amuL ;6 ;6 aX sb; ;; ;; L sb lmk ;slU saX ; sX sx ms X u s X sa

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b lmlslam; a ; Xlao; k X; k ms; C ;D X Ulk m uan) b (Xlm l( u lmk ;slU saX l;X ;(am;l u aX m;oXlmU sb s uu ;s lmkauk lm sb sXl u l; xlul X nlsb sb ams ms a sbl; ; slam)

m aX X slam l; lm ; mL omsan X x l u a oXX m sb s3•� X ;ous; lm sb6 l; lxx l s uL ul csbX s mlmU6•� X TolX ; s u ;s %+cbaoX lm( sl ms ba;(ls ulF slam aX (XauamU slam a wl;slmU

ba;(ls ulF slam6•� X ;ous; lm ( X;l;s ms aX ;lUmll ms l; lulsLflm ( lsL6•� o; ; amU mls u max uLf lXsb s)

l u m ; l msll io Ux ms ;baou w X l; lm l lmU nb sb X w( ls X (aXslmU l;((Xa(Xl s lm asb X ;lso slam;6 ;o b ; lx(aXs ms x l u k ms; sb s x L mas lxx l s uL ul csbX s mlmU aX X ;ous lm sb aX ba;(ls ulF slam6 os x L i a( X lF sb ;o i s aX x L X TolX

lms Xk mslam sa (X k ms am a sb asb X aos ax ; ul;s lm sb (X klao; lmlslam) b ; ;baouu;a o;o uuL am;l X ; Xlao;) w x(u ; a ;o b k ms; X lms m;lk sX sx ms lm mx XU m L Xaax aX s bax aX uu XUl Xam ba;( ;x0 uaa L; X ;l ; aX amkou;lam; sb s a masX ;ous lm ba;(ls ulF slam0 aX k ua(x ms a XoU ( m m L aX XoU o; ) sb o sa l; ;(XaUX ;;lam nluu X aX am sb ) l; lm ; ;o;( s om w( s 6 m

X (aXslmU l; m ax( ;; nlsblm X (aXslmU Uol ulm ; ; lm lm sbl; ; slam)

X sx ms nlsblm aX xl;;lam sa sb auuanlmU lulsl ; l; mas am;l X sa x s sb Xls Xl aplm( sl ms ba;(ls ulF slame C usbaoUb l mL asb X Xls Xl X x s6 sb k ms xo;s ;sluusX s ; m m lxx l s uL X (aXs D3

•� x XU m L ( Xsx ms aX x XU m L aax•� os( sl ms aX ; x c L ;oXU XL omls;•� ; Xk slam aX ;baXsc;s L omls•� b luls slam lulsL•� a;(l aX ;tluu moX;lmU lulsL•� oX;lmU bax ;6 o;sa l u X aX ;(ls X lulsL

a;(ls ulF slam oXlmU sb sXl u aX (X c(u mm ;oXUl u aX x l u (Xa oX Cam nbl b n ;(u mm (XlaX sa msXL lm sb sXl uD a ; mas X TolX X (aXslmU ; ; Xlao; k X; k ms sa sb(am;aX C X) l b u kLD)0foPof� KBNUG D KG D CR SNKRBCT r CD GRBT RNKG

s l; lx(aXs ms sa l;slmUol;b sn m p; Xlao;e m p; k X e k X; k ms;6 ; sb s Xx; X mas;LmamLxao;) k XlsL l; x ;oX a lms m;lsL0 ban k X6 m a ; k X lms m;lsL m masm ;; XluL am;l X ; Xlao;) aX w x(u 6 m o; 6 nbl b ( X;l;s; aX ; k X u baoX;6 x Lam;l X ; k X m o; 6 os x L mas am;l X m ) m sb asb X b m 6 ;sXat nbl bX ;ous; lm amuL ulxls UX a l; lulsL x L am;l X amuL xlu ;sXat 6 os naouam;l X m ) k XlsL m ; Xlao;m ;; ;baou lm ( m msuL ;; ;; nb m X aX lmU; m ; am sb )

k X; k ms; u ;;ll L sb sX slmU lmk ;slU saX ; G KBNUG X TolX w( lslao; b m ulmU mX (aXslmU sa sb aX asb X X Uou saXL U m l ; lm aX X sa ax(uL nlsb X Uou saXL X TolX x ms;)

Xlao; k X; k ms; x L a oX s mL slx Xax sb ;lUmlmU a sb lmaXx am; ms aXxsbXaoUb sb Scxamsb auuanco( ( Xla s X sb u ;s sXl u sX sx ms) (am;aX aX ;lUm xo;smasll a uu ;6 X U X u ;; a o; ulsL6 nlsblm %+ baoX; a sb lX;s tmanu U a sb k ms Lsb sX slmU (bL;l l m aX X ; X b ( X;amm u)

N K SNKR C t G RA SSKNSKB R S T ouu ; m x l uuL amlXx sb; CX U X u ;; a o; ulsL ;; ;;x msD a oXXlmU am sXl u

sX sx ms aX nlsblm 8® L; a u ;s sXl u sX sx ms xo;s X (aXs sa sb b X ( osl ;6 sbabm; a(tlm; m sb b lX a sb ; ; nlsblm sb m auuan omslu X ;auoslamCnlsb osa(;L X (aXs l ((ul u D)

sb; a oXXlmU nlsblm 8® L; s X u ;s sXl u sX sx ms sb s X x y(a;;l uLh aX y(Xa uLhX u s sa o ulsowlx xo;s X (aXs ; ; nlsblm sb Cnlsb m osa(;L X (aXs lk lu u D)

sb; a oXXlmU nlsblm 8® L; s X u ;s sXl u sX sx ms m mas ssXl os sa sXl u sX sx msC )U)6 l; ; (XaUX ;;lamD m mas X (aXs lm m w( lslao; x mm X sa sb b X ( osl ;m sb b lX a sb 6 os m ;lx(uL (soX am sb ((Xa(Xl s ; m C sbD)b abm; a(tlm; ;baou masll ; ;aam ; (a;;l u )

b lmk ;slU saX xo;s X kl n m ;lUm a am sb s am sb X (aXs) b nluuX (aXs sa sb (am;aX CaX (am;aX ;lUm D ; aosulm lm sb sL amlsaXlmU u m)

m l; X (aXs sa sb ;(am;aX aX ;lUm kl w6 sb ; x lmaXx slam xo;s ms X amsb nlsblm %+ baoX; C9 o;lm ;; LD) X m;xl;;lam a sb X (aXs ;baou amlXx Lsb ;ls ( X;amm u ;o xlsslmU sb X (aXs)

auuanco( lmaXx slam aX ; m lmaXx slam am mamc; Xlao; ; sb s ax ; Xlao; ;baouu;a X (aXs sa sb ;(am;aX aX ;lUm ; ;aam ; ls l; k lu u 0 sb ; X (aXs; ;baou;o xlss o;lmU sb ((Xa(Xl s ) b s lu X (aXslmU (Xa ;; nluu (Xakl sa sb;ls ; lm sb sL amlsaXlmU u m)

mk ;slU saX; xo;s X (aXs ; m auuanco( lmaXx slam sa sb lX X ;(am;l u m;slsoslam u kl na X C ;Df m ( m ms sbl ; axxlss aX lmU sa sb (aul l ; a sb X ;(am;l u

C ; X b sbl ; axxlss D)

0foy�b (am;aX C X) kLD nlsb ;;l;s m Xax b X ( osl ; X X ;(am;l u aX X (aXslmU X u k ms

; sa sb ax( s ms osbaXlsL6 asb X ((ul u X Uou saXL osbaXlsl ;6 m ( Xsl l( slmUlmk ;slU saX;6 lm aX m nlsb Uol ulm ;6 X Uou slam;6 m faX ua u X Uou saXLX TolX x ms;)

b (am;aX C X) kLD nlsb ;;l;s m Xax b X ( osl ; X X ;(am;l u aX X (aXslmUom w( s s u aX ul csbX s mlmU k ms; ;;a l s nlsb sb o; a sb sXl u XoU sa sbX Uou saXL U m l ; m ax( s ms osbaXlsl ; kl s u (bam aX w nlsblm G u m X L; s X

lmU masll a sb k ms) b (am;aX nluu X (aXs uu X u s os om w( s ; lm uo lmUmamc sbfmamcul csbX s mlmU X u s os om w( s ; ;;a l s nlsb sb o; a sb sXl ux l slam sa b X ( osl ; m sb abm; a(tlm; ; L ; sL X (aXs nlsblm 9+ u m X

L; a masll slam) b X ( osl ; l; X TolX sa maslL sb )

0fob�mk ;slU saX; nluu o; aXX s x l u s XxlmauaULf am (s; nb m X aX lmU ; aX ; am sb

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uu ;6 lm uo lmU sba; sb s x s X (aXslmU Xls Xl 6 nluu X aX am sb 0 ; sb sx s sb lmlslam a m nluu lslam uuL X (aXs auuanlmU sb (Xa oX ; mas lm

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3 m a mo;lam9Hfc W xlmos ;%Hfc 8® xlmos ;8Hfc % baoX;

x(ulmU Xa oX ; csa( m ;s Xs slx ; a lmo;lam xo;s X aX m so u slx f s ; a ; x(u ; X nm

xo;s (Xakl ) b ;o i s nluu mas X lk mL lslam u lmo;lam; a o ulsowlx )uu ; x(u ; sa a s lm aX m uL;l; a o ulsowlx nluu ; Xox) m Ecxu uaa ; x(u l;

X TolX aX b ; x(u slx (alms)s X msXloU slam6 % ulToas; a ®)W xu a ; Xox ;baou ;saX s c%®1 sa G®1 s sb ;ls ) mulToas nluu ; ms sa b X ( osl ; m sb ; am ulToas nluu ;bl(( sa b X ( osl ;s X sb lX;s ; x(u l; X lk L sb x) uu ; x(u ; xo;s ; ms nlsblm 9+ L; a lmUauu s Xax sb ;o i s)((Xawlx s uL ; k m CGD ; x(u ; ak X G L; ;baou auu s aX sb m uL;l; a

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)� Xl(b X u uaa l; sa X nm lmsa b ( XlmlF k os lm X so ;) b ( sl msh; lmlsl u;6slx ; x(u a s lm 6 m s ; x(u n ; a s lm ;baou X aX am b so; n uu ; am sb X ;( slk slx ;b s lm sb )

)� lsblm %® xlmos ; a auu slam6 msXloU sb uaa ; x(u ; s S®®wU aX 9W xlmos ; sa; ( X s (u ;x )

)� aX b ; x(u auu s 6 (l( ss o(ul s ulToas; a (u ;x 6 % xu b6 lm(auL(Xa(Lu m XLakl u; C om D) ulToas 9 l; sb ; x(u m ulToas % l; sb o(ul s )

)� ulToas; X sa XaF m m ;saX s c%®1 sa AcG®1 aX uan X omslu ;( lx m; X;bl(( sa ;bl(( sa b X ( osl ;) uu ; x(u ; xo;s ;bl(( nlsblm 9+ L;auuanlmU auu slam aX oXsb X ;saX U m faX m uL;l;)

)� ( lx m; m s b aX ;bl(x ms am uu ; x(u ; b k m auu s aX( sl ms nlsblm 9+ L; a lmU auu s )

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)� x(u ; x L ;saX s sb ;ls aX o( sa 9+ L;) x(u ; X sa ;bl(( ak XmlUbslm ;ol l ms XL l sa t ( ; x(u ; XaF m)

)� m ulToas Xax b ; x(u nluu ;bl(( m sb o(ul s ; x(u ; m ; msam b X ( osl ; k Xll ; sb L b k X lk sb lX;s ulToas) U lm6 uu ; x(u ;xo;s ;bl(( nlsb 9+ L;)

)� a mas ;bl( ; x(u ; m o(ul s ; lm sb ; x aw) k sb o(ul s ; m ;bl( sb xs X b X ( osl ; b ; k Xll sb L b k X lk sb lX;s ulToas)

)� u sb ( sl ms uan ;b s; lm ; ( X s (u ;sl U m sb m (u lm sb ;bl((lmU aw))� u ; ams s b X ( osl ; lsb X L (bam aX L x lu aX ;bl((lmU ; x(u ;)

bl; l; sa ;;oX sb s ;bl(x ms; m X lk am sb s L) bl; l; ;( l uuLlx(aXs ms l ;bl((lmU am boX; L aX Xl L ulk XL)

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(X c wl;slmU x l u am lslam l; am sb s l; (X ; ms s sb ;s Xs a sb sXl u) o b am lslam; nluuX aX am sb sXl uh; ((Xa(Xl s x l u bl;saXL ) (X c wl;slmU x l u am lslam nluu

X aX ; m aX amuL l sb X To m L6 ; k XlsL6 aX b X s X a sb am lslam naX; m;oXlmU sb sXl u) b m X aX lmU ;o b k ms; am sb ((Xa(Xl s ; (aXs aXx6 ls l; lx(aXs ms

sa amk L sb am (s sb s sb (X c wl;slmU am lslam b ; b mU L lm uo lmU ((ul u; Xl(saX;)

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X Um m L6 aXslam6 lXsb s;6 m amU mls u max ul ; X k ms; a ;( l u lms X ;s6 ;; Xl uan lm ; slam 9%)99)G)

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b auuanlmU X k ms; a ;( l u lms X ;s6 m nluu X (aXs w( lslao;uL3

K TC C rt NKRBNCt BKRA RGv NCT CBR O CNF OB G ;o i s ax ; (X Um ms nblu mXauu lm sb sXl u6 b X ( osl ; nluu masllw( lslao;uL6 X U X u ;; a nb sb X aX mas ls x s; sb Xls Xl aX w( ls X (aXslmU) aXslam;C;(ams m ao;6 l ms u6 aX sb X ( osl D nluu u;a X (aXs sa b X ( osl ;)

amU mls u max ul ;f lXsb s; O. rGx s Xls Xl 6 m nluu sb X aX w( lslao;uLX (aXs ; m 6 o;lmU sb (X klao;uL ; Xl (Xa ;; aX X (aXslmU)

KB O KUT D K NGLx(sax sl m mamc;Lx(sax sl ak X a; nluu X (aXs lm sb ) mL l ms u aX

lms mslam u ak X a; nlsb sb sXl u sX sx ms sb s l; ;Lx(sax sl 6 k m l mas ouluulmU ; Xlao;m ;;Xls Xlam6 nluu X (aXs sa b X ( osl ; lxx l s uL Cnlsblm %+ baoX;D o;lmU sbaXX ;(am lmU ( U 6 m auuanlmU sb ; x (Xa ;; ; Xl aX ; C; slam 9+D) sXl u XoU ak X a; a oX;6 ;o i s; nluu ;sa( sXl u XoU a;lmU m ulml uuL xamlsaX ;((Xa(Xl s 6 x m UlmU ;Lx(sax;f;l s; sb s x L a oX)

0p�m lm ( m ms nluu lm b XU a X kl nlmU ; sL s ) m aX X sa m;oX ; sL m ulxls

sawl lsL aX mXauu ;o i s;6 sb nluu x s s u ;s am C(XlaX sa ;o i s mXauux msCaXU mlF slam u x slmUDD6 s X sna ;o i s; b k m lmo; nlsb sXl u XoU m lm u ; sLX kl n x slmU s X sb lsb ;o i s ax(u s sb ;so L) b auuanlmU k X; k ms; nluuauuan L sb 3 m osXa( ml 6 sbXax a Lsa( ml 6 lm slam6 m u k slam; lm ulk X mFLx ;)b ; k ms; nluu X kl n L sb nb m sna C%D ;o i s; mXauu b k ax(u s

sX sx ms nlsb m ;s Xal ; aX k XL ;lw Cxamsb;D6 nbl b k X a oX; lX;s6 oXlmU sb aoX; asb sXl u) uu asb X ; Xlao; m mamc; Xlao; k X; k ms; nluu a ox ms ) b nluu uaats sb sas u ; sL s lm s XxlmlmU nb sb X ls l; (a;;l u sa a; sb m ws sbX C8D ;o i s; lmsbl; sXl u)

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b (am;aX C X) kLD nluu sX m; XXlmU sb X Uou saXL a ulU slam aX xamlsaXlmU sbl; sXl u ms x m U x ms sa b X ( osl ;6 m ) ls xamlsaXlmU ;b uu am o s sa m;oX sb box m

;o i s (Xas slam6 sXl u (Xa oX ;6 u aX saXL6 sXl u lms Xk mslam xlml;sX slam6 m sauu slam (Xa ;; ; X a blUb To ulsL m x s sb b X ( osl ; ;6 f m 6 nb m((Xa(Xl s 6 X Uou saXL Uol ulm ;) b ls amlsaXlmU u m ;b uu lm ;( s; a sb xamlsaXlmU(Xa ;;)

b X ( osl ; nluu kl;ls abm; a(tlm; nlsblm E xamsb; (XlaX sa lmlsl slmU sb (Xasa au sa lm;( ssb XoU ;saX U X 6 m ouuL lmaXx sb mk ;slU saX a bl;fb X X ;(am;l lulsl ; aX ;so l ; msb (Xa oX ; aX ;;oXlmU To s m aXX s a ox ms slam) sXl u lmlsl slam ;ls kl;ls aXs u am X m nluu ( XaXx sa X kl n lmk ;slU saX X ;(am;l lulsl ;6 sb (Xasa au6 m ls;X TolX x ms; nlsb sb mk ;slU saXC;D) oXlmU sb lmlsl slam6 sb ; X (aXs aXx; C ;D masb X ( Xslm ms sXl u x s Xl u; nluu X kl n nlsb sb lmk ;slU saXh; X ; X b ;s ) oXlmU sbaoX; a sb sXl u6 b X ( osl ; nluu x t kl;ls; sa sb ;ls ; ; m ;; XL lm aX X sa X kl n(Xasa au ax(ul m 6 w xlm ;6 m lm lkl o u ;o i s x l u X aX ;6 m m;oX sb s sbsXl u l; lmU am o s aX lmU sa sb (Xasa au m ( Xslm ms X Uou saXL X TolX x ms;) u s

msXl ; nluu k Xll nlsb ;aoX a ox ms slam) b X kl n a x l u X aX ; nluu amlm x mm X sa ;;oX sb s ;o i s aml msl ulsL l; x lms lm )

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X ; X b (aul l ; m (Xa oX ; m mL asb X ua u ((ul u X Uou saXL X TolX x msC;D)

0Jo0�b sXl u (Xasa au6 6 6 k lu u ; sL lmaXx slam6 ;o i s a ox ms;6 ;o i s X Xolsx ms

(Xa oX ; C )U)6 k Xsl; x ms;D6 lmaXx slam aos ( Lx ms; Cl) )6 ( Lx ms;D max( m; slam k lu u sa sb ;o i s; m a ox ms slam kl m lmU sb h; To ull slam; xo;s;o xlss sa sb aX sbl u X kl n m ((Xak u (XlaX sa sb sXl u ;s Xs)

b (am;aX C X) kLD m faX ;lUm nluu auuan uu m ;; XL X Uou slam; sa m;oX lmlsl u mamUalmU6 sXl u X kl n) b (am;aX C X) kLD6 ; ((Xa(Xl s xo;s ;o xls m 6 nb Xm ;; XL6 a s lm ((Xak u Xax sb aX uu ;o ; To ms (Xasa au x m x ms; m b mU ; sasb lmaXx am; ms a ox ms)

((ul u 6 sb nluu maslL sb .BRABC bh rG a sb m a sb sXl u6 aX l sb sXl us Xxlm s ; XuL6 sb xo;s maslL sb .BRABC 0x rG a sb s Xxlm slam) X ;am aX sbXuL s Xxlm slam xo;s (Xakl C ; lm lm lX slk %®®9f%®f D) b (am;aX nluu lsb X

(X ( X aX X kl n uu ;o xl;;lam a ox ms; (XlaX sa ;o xl;;lam sa sb )

sL o( s ; aX o ulsowlx nluu (X ( X L sb (am;aX aX ls; X (X ; ms slk Cb X ( osl ;6 m )D ; X TolX 6 aX ;o xl;;lam sa sb X u k ms )

0Jof�; X TolX L ua u X Uou slam;6 sb (am;aX C X) kLD nluu m;oX uu u U u ;( s; X ak X 6m ((Xak u a sb ((Xa(Xl s X Uou saXL a l ; a s lm 6 (XlaX sa sXl u lmlsl slam) X TolX 6 sb(am;aX nluu u;a m;oX sb s sb lx(u x ms slam a ;o ;s msl u x m x ms sa sb (Xasa au m

asb X X u k ms sXl u a ox ms; b (( m amuL s X ((Xak u L sb X u k ms X Uou saXL osbaXlsl ;)

sL o( s ; aX o ulsowlx nluu (X ( X L sb (am;aX aX ls; X (X ; ms slk Cb X ( osl ;6 m )D ; X TolX 6 aX ;o xl;;lam sa sb X u k ms X Uou saXL osbaXlsL)

0Jop�s lu; a lm;oX m m faX lm xmlsL nluu ams lm nlsblm sb nXlss m UX x ms sn m

abm; a(tlm; m b X ( osl ;)

0Jox�maXx am; ms l; (Xa ;; L nbl b ;o i s kauoms XluL amlXx; bl; aX b X nluulmUm ;; sa( Xsl l( s lm ( Xsl ou X sXl u6 s X b klmU m lmaXx a uu ;( s; a sb sXl u sb s XX u k ms sa sb ;o i sQ; l;lam sa ( Xsl l( s ) maXx am; ms l; a ox ms L x m; anXlss m6 ;lUm m s lmaXx am; ms aXx)

b nluu ;o xlss aX ((Xak u sa sb sb s l; X ;(am;l u aX X kl n m ((Xak u a sbsXl u) b am; ms aXx nluu lm uo uu a sb X u k ms u x ms; oXX msuL X TolX L sbX ;(am;l u X Uou saXL osbaXlsL6 ; n uu ; ua u aomsL osbaXlsL aX ;s s X Uou slam; m m slam uX TolX x ms;)

aX X Xolsx ms m mXauux ms lmsa sb sXl u6 b (Xa;( slk m l s nluu Ulk m ouuw(u m slam a sb sXl u) m sb ;; msl u lmaXx slam b ; m (Xakl sa sb (Xa;( slkm l s 6 m sb lmk ;slU saX l; ;oX sb s sb lm lkl o u m l s om X;s m ; sb lx(ul slam; a

( Xsl l( slmU lm sbl; sXl u6 sb m l s nluu ;t sa Ulk am; ms sa ( Xsl l( s lm sb sXl u L;lUmlmU m lmaXx am; ms aXx) mas slam sb s nXlss m lmaXx am; ms b ; m a s lm nluu

x lm sb ;o i sh; x l u X aX ) a(L a sb lmaXx am; ms aXx6 sa lm uo sb;o i sh; ;lUm soX 6 nluu (Xakl L sb lmk ;slU saX sa sb ;o i s)

m x m x ms sa sb (Xasa au ;o ;s msl uuL us X; sb sXl u ;lUm aX sb (as msl u Xl;t; sa sb;o i s;6 sb ;o i sh; am; ms sa amslmo ( Xsl l( slam lm sb sXl u xo;s a s lm )

0JoJ�

0JoJo0� U L R NCB CRB OBRr

aml msl ulsL a ;o i sh; ( X;am u s nluu (Xas s lm aX m nlsb e:L usb m;oX maXs lulsL m aoms lulsL s a 9SSE C D6 m m slam u s (Xas slam u n;)

X Uou slam; X TolX sb s6 lm aX X sa ( Xsl l( s lm sb sXl u6 ;o i s xo;s ;lUm m osbaXlF slamXax sb sXl u sb s b aX ;b b ; m lmaXx a auuanlmU3

•� b s (Xas s b usb lmaXx slam C D nluu auu s Xax ;o i s; lm sbl; sXl u0•� ba nluu b k ;; sa sb s lmaXx slam m nbL0•� ba nluu o; aX l; ua; sb s lmaXx slam0•� b s b usb lmaXx slam x L oXsb X l; ua; L sb X l(l ms; a sb lmaXx slam6 m

sb s l sb lmaXx slam l; l; ua; sb lmaXx slam x L ma uamU X (Xas s L X u aX;s s (Xlk L u n;0

•� b lmaXx slam auu s aos sb X ; X b sXl u nluu t (s ; ( X s Xax sb ;o i sh;x l u X aX ;6 os sb ;o i s nluu u sa a s lm sb X ; X b X aX ; s X sbam uo;lam a sb sXl u0

•� b sb X sb osbaXlF slam ams lm; m w(lX slam s 0 m•� b XlUbs; a X ; X b ;o i s sa X kat bl; aX b X osbaXlF slam)

m sb k ms sb s ;o i s X kat ; osbaXlF slam sa auu s aX o; bl; aX b X 6 sb lmk ;slU saX6 LX Uou slam6 X s lm; sb lulsL sa o; uu lmaXx slam auu s (XlaX sa sb X ka slam a ;o i sosbaXlF slam) aX ;o i s; sb s b k X kat osbaXlF slam sa auu s aX o; 6 ss x(s; nluux sa a s lm ( Xxl;;lam sa auu s s u ;s kls u ;s so; Cl) )6 sb s sb ;o i s l; ulk D s sb m asb lX ; b ou sXl u ( Xla )

m ax(ul m nlsb Uol ulm ; m ((ul u ( Xs; a %9 ls l; X TolX x ms sb s sblmk ;slU saX m lm;slsoslam ( Xxls osbaXlF X (X ; ms slk ; a b X ( osl ;6 sb X Uou saXLosbaXlsl ; m sb lX s ;; sa X kl n sb ;o i sh; aXlUlm u x l u X aX ; s sb ;ls aXk Xll slam a sXl ucX u s (Xa oX ; m s )

;oX ; sa (Xas s aml msl ulsL lm uo 3 amuL omlTo sXl u mox X m lmlsl u; nluu l mslL;o i s; am sb aX asb X a ox ms; ;o xlss sa sb (am;aX) bl; lmaXx slam6 saU sb X nlsbsb ;o i sh; s a lXsb6 nluu o; lm sb s ; aX ;o i s l msll slam) o i s m x ; aX

X ;; ; nluu mas ms X lm sb aX s ; ) a x s Xl u XlmU ;o i sh; m x nluut (s am lu L sb (am;aX) o i s; nluu lmaXx a sb lX XlUbs; nlsblm sb )

0JoV�X;am u s a sb lmk ;slU saX; m ;o clmk ;slU saX; x L lm uo lm sb (am;aX s ; 6

m ;b uu sX s lm ax(ul m nlsb uu ((ul u u n; m X Uou slam;) b m X blklmU aX(Xa ;;lmU ( X;am u s ( Xs lmlmU sa sb lmk ;slU saX aX ;o clmk ;slU saX6 sb (am;aX nluu s t uu((Xa(Xl s x ;oX ; sa ; Uo X m (X k ms ;; sa sbl; s L mL om osbaXlF ( XsL)

0JoP�b lm m ; aX sbl; sXl u nluu ;o i s sa ; ( X s nXlss m UX x ms sn m sbb X ( osl ; m abm; a(tlm; mlk X;lsL) uu mk ;slU saX lm m l u l; ua;oX ; ; ((ul u sa

%9 Xs W+ nluu ((Xa(Xl s uL (Xakl m X kl n L sb abm; a(tlm; )

0V�

0Vo0�x m x ms; sa sb (Xasa au ;b uu (u mm 6 a ox ms m ;lUm soX osbaXlF (XlaX sa

lx(u x ms slam)

m x m x ms sa sb (Xasa au l; X TolX 6 sb x m x ms nluu aXlUlm s m a ox ms Lsb (am;aX) b nXlss m x m x ms xo;s ;o xlss sa sb abm; a(tlm; aX sb a X h;((Xak u)

x m x ms; ;( ll uuL lmkauklmU b mU sa sXl u ;lUm6 Xl;t sa ;o i s6 lm X ; sa a;lmU aXw(a;oX 6 ;o i s mox X lm X ; 6 lslam aX X xak u a m n s ;s; aX (Xa oX ;6 nluuX kl n m ((Xak L sb s sb mk ;slU saXh; lulsL)

b x m x ms nluu ;o xlss aXx uuL sa sb aX asb X X Uou saXL osbaXlsl ; L sb(am;aX ; ((ul u 6 m ;( ll uuL nb m m lm X ; sa a;lmU aX ;o i s w(a;oX m faX

;o i s mox X b ; m (Xa(a; 0 aX6 nb m sb lslam aX X xak u a m mk ;slU saX l;m ;;ls s )

s x; X TolXlmU (Xasa au x m x ms nlsb m m faX m ax( s ms osbaXlsL((Xak u lm uo 6 os X mas ulxls sa6 sb auuanlmU3

•� b mU sa sXl u ;lUm•� l;t sa ;o i s•� m X ; sa a; aX ;o i s w(a;oX sa XoU•� o i s mox X lm X ; a xaX sb m %®J•� lslam aX X xak u a s ;s; m f aX (Xa oX ;•� lslamfX xak u a m n mk ;slU saX

s ;baou oXsb X mas sb s6 l m x m x ms sa sb (Xasa au ;o ;s msl uuL us X; sb sXl u ;lUmaX sb (as msl u Xl;t; sa sb ;o i s;6 sb lX am; ms sa amslmo ( Xsl l( slam lm sb sXl u nluua s lm )

0Vof�aX sb sXl u x L Ulm6 Xs lm a ox ms slam X TolX L X Uou slam; nluu (Xakl L

sb mk ;slU saX) b X TolX a ox ms slam nluu t (s L sb (am;aX)

a ox ms; s xlmlxox X TolX sa Ulm sb sXl u lm uo 6 os X mas ulxls sa6 sb auuanlmU3

•� ;lUm soX c osbaXlF (Xasa au m amsX s0•� a(L a sb al l u ((Xak u a sb sXl u m sb x x X; ul;s0•� oXX ms oXXl ou ls aX sb (Xlm l( u lmk ;slU saX m mL ;;a l s lmk ;slU saXC;D nba

nluu lmkauk lm sb sXl u0•� m l slam a ((Xa(Xl s X ls slam aX mL u aX saXl ; sa o; lm sb sXl u m

a(L a sb maXx u X mU ; aX s ;s; sa ( XaXx L sb s u aX saXL0•� XlUlm u aXx 9WG% C s s x ms a mk ;slU saXD6 ((Xa(Xl s uL ax(u s m ;lUm 0•� a(L a sb c ((Xak am; ms aXx ams lmlmU ( Xxl;;lam aX o ls L sb abm;

a(tlm; m faX sb 0•� lm m l u l; ua;oX aXx; aX uu lmk ;slU saX; ul;s am aXx 9WG%0•� Xsll s aX sXl u sX lmlmU0•� ls To ull slam X (aXs;6 nb X ((ul u 0

•� Xll slam a Xlm l( u mk ;slU saX (s lulsL Xax ua u m faX m slam u Xx msul;sC;D)

b (am;aX nluu m;oX sb s uu a ox ms slam sb s l; X TolX sa lm (u aX sb sXl u x L;s Xs6 lm aX m nlsb E m (am;aX ;6 nluu k lu u aX mL sXl u ;ls ; Xlmlsl s )

0Vop�b nluu x lms lm ul;s a ((Xa(Xl s uL To ull ( X;am; sa nbax b f;b b ; u U s sXl uosl ; m nluu m;oX sb s uu ( X;am; ;;l;slmU lm sb am o s a sb sXl u X lmaXx a sb lX

a ulU slam;) uu ( X;am; osbaXlF sa x t msXl ; m faX aXX slam; am sb ; nluu lm uoam sbl; a ox ms) uu msXl ; lm sb ;o i sh; nluu ;o((aXs L ;aoX a ox ms slam nb X((Xa(Xl s )

aoX a ox ms; X sb aXlUlm u a ox ms;6 s 6 X aX ; m Xsll a(l ; a aXlUlm u X aX ;a ulml u lm lmU;6 a ; Xk slam; m slklsl ; Xax nbl b sb ;o i sh; s X a s lm )b ; m lm uo 6 os X mas ulxls sa6 ba;(ls u X aX ;6 ulml u m al b Xs;6 u aX saXL6

x l acs bml u ( Xsx ms m (b Xx L X aX ;6 l Xl ;6 xl Xal b ;6 sX ;6 a(l ; aXsX m; Xl(slam; Xsll s X k Xll slam ; lmU oX s m ax(u s 6 (basaUX (bl m U slk ;6xl Xalux aX x Um sl x l 6 cX L;6 m aXX ;(am m )

b m sXl u ;s X X ;(am;l u aX x lms lmlmU ax(X b m;lk m msX ulF lulmU ;L;s xC ls Xl u lu f aX D a uu sXl ucX u s C ;; msl uD a ox ms slam6 ;ols u aX lm;( slam smL slx L X (X ; ms slk ; a ((ul u X Uou saXL osbaXlsl ;) b f xo;s am;l;s a sba;a ox ms; sb s lm lkl o uuL aX auu slk uL ( Xxls k uo slam a sb am o s a sb sXl u m sb

To ulsL a sb s (Xa o ) b f nluu ams lm ; xlmlxox uu X u k ms a ox ms; maXX ;(am m ; aosulm lm slam 98 m %9 Xs 89%)WG6 lm uo lmU t La ox ms; ;o b ; sb m mL x m x ms;6 (Xasa au m mL x m x ms;6 ;lUm ;6 a(l ;

a ax(u s ;6 ((Xak u a ox ms;6 lm m l u l; ua;oX aXx;6 ;o i s l msll slam ul;s;6mXauux ms uaU;6 u U slam a osbaXlsL uaU6 ;s To ull slam a ox ms;6 u aX saXL maXx uX mU ;6 X aX ; X u slmU sa sb sXl u XoU lm uo lmU aoms lulsL X aX ;) XoU aoms lulsLX aX ; nluu6 s xlmlxox6 ams lm lmaXx slam X U X lmU X l(s6 ;bl(x ms6 m l;(a;lslam) baXx a XoU aoms lulsL X aX 6 s xlmlxox6 nluu ams lm m x 6 s XoU;bl(( fX lk 6 s 6 To mslsL m s bf a 6 aX uas mox X aX l mslsL a b ;bl(x ms) m

lslam6 uu aXlUlm u ;aoX a ox ms; ;o((aXslmU msXl ; lm sb nluu x lms lm mX luL k lu u )

b (am;aXflmk ;slU saX C X) kLD nluu x lms lm To s lmk ;slU slam u (Xa o s X aX ; mlm m l u lms X ;s X aX ; ; ( X %9 Xs W+)E m Xs 89%)WG aX ma u ;; sb m % L X; s X sbu ;s x Xt slmU ((ul slam b ; m ((Xak L 0 aX6 lm sb k ms sb s sb x Xt slmU((ul slam b ; mas m ((Xak L 6 aX ma u ;; sb m % L X; s X sb u ;s ;bl(x ms fulk XL a sb XoU aX lmk ;slU slam u o; l; l; amslmo m b ; m masll a sbl; amslmo slam)

b ;b uu x lms lm To s a ox ms slam f X aX ; a slklsl ; ; ( X %9Xs WE)99W aX s u ;s 8 L X; s X ax(u slam a sb X ; X b)

a m u k uo slam; m faX o ls; Xax X Uou saXL osbaXlsl ;6 sb lmk ;slU saX lslam uuL nluut ( X aX ;6 lm uo lmU sb l mslsL a uu ( Xsl l( slmU ;o i s; C;ol l ms lmaXx slam sa ulmtX aX ; )U)6 x l u X aX ;D6 uu aXlUlm u6 ;lUm lmaXx am; ms aXx;6 m a(l ; a uu ;6 6;aoX a ox ms;6 s lu X aX ; a sX sx ms l;(a;lslam6 m X u s ;; msl u X Uou saXLa ox ms;) b a ox ms; ul;s ak nluu X s lm L sb lmk ;slU saX aX ; uamU ; m

sa ax(uL nlsb m slam u m lms Xm slam u X Uou slam; CU m X uuL % L X; s X l; amslmolmU ulml u

k ua(x ms aX s X sb u ;s x Xt slmU ((Xak uD) b X ( osl ; aX ls; X (X ; ms slk nluumaslL X) kL CaX abm; a(tlm; mlk X;lsLD nb m sb sXl ucX u s X aX ; X ma uamU X X TolX )

0Vox�b sXl u l; sb (Xlx XL s auu slam lm;sXox ms aX sb sXl u) ; X (aXs aXx C D nluu

oslulF aX sb auu slam a uu s m uu s nluu ms X o;lmU sb mUul;b u mUo U m;baou t (s oXX ms sa m u sb xamlsaX sa X kl n sb ;o i s;h ;s so; sbXaoUbaos sb aoX; asb sXl u)

m aX X sa x lms lm aml msl ulsL6 amuL sXl u mox X6 ;o i s mox X6 lmlsl u; m s a lXsbx L o; sa l mslL sb ;o i s lm sb ) sb ;o i sh; m x (( X; am mL asb Xa ox ms C )U) u aX saXL X (aXsD6 ls nluu a uls X s am sb a(L a sb a ox ms sa ;o((ul

sa sb lmk ;slU saX ;ls m X (u lm;s nlsb sb ;o i s mox X m ;o i sh; lmlsl u;) blmk ;slU saX nluu x lms lm ( X;am u ;o i s l msll slam ul;s C;o i s mox X; nlsbaXX ;(am lmU ;o i s l msll X;D sa m u X aX ; sa l msll m k Xll ; osb msl )o i s s flmaXx slam nluu t (s aml msl u6 m nluu x m U aX lmU sa ((ul u

ua u6 ;s s 6 m X u X Uou slam;)

0VoJ� t t

b lmk ;slU saX nluu ( Xxls sXl ucX u s xamlsaXlmU6 To ulsL o ls;6 m lm;( slam; Lb X ( osl ; m Uak Xmx ms X Uou saXL osbaXlsl ; a uu sXl ucX u s a ox ms; C )U)6 ;aoXa ox ms;6 X Uou saXL a ox ms;6 s auu slam lm;sXox ms;6 ; X (aXs aXx;D) b

lmk ;slU saX nluu m;oX sb ( lulsL aX lm;( slam; a ((ul u sXl ucX u s lulsl ;) blmk ;slU saX nluu m;oX sb s sb sXl u xamlsaX aX mL asb X ax(ul m aX X kl n X l; Ulk m

;; sa uu sXl ucX u s a ox ms; m sXl ucX u s lulsl ;)

Xsl l( slam ; m lmk ;slU saX lm sbl; sXl u lx(ul ; sb (s m a (as msl u lm;( slam LUak Xmx ms X Uou saXL osbaXlsl ;6 sb ;(am;aX aX ls; X (X ; ms slk C;D)

s sb (am;aXh; l; X slam aoX a ox ms Xll slam C D x L ( XaXx am uu s ls x;aX ( X ms U sb X a)

0VoV�m lslam sa sb ulml u amlsaXlmU ax(am ms a sbl; (Xasa au6 sb b X ( osl ;h; o ulsL;;oX m C D ( Xsx ms ;b uu ;s ul;b m o lslmU u m a ox ms ; ( X s Xax sb (Xasa au

sa ;s ul;b sb Xls Xl L nbl b lm ( m ms o lslmU ;b uu am o s oXlmU sb am o s a sbsXl u sa ;; ;; ax(ul m nlsb m ((ul u X Uou saXL X TolX x ms;) s aXa ox ms slam o ls ;b uu ;; ;; aX ax(ul m sa sb (Xasa au6 oX L lm X u slam sa

;aoX a ox ms; m ax(ul m sa ((ul u X Uou slam;)

0VoP�uu lmaXx slam (Xakl X U X lmU sb sXl u6 ; n uu ; uu lmaXx slam auu s f a ox msoXlmU sb aoX; a sb sXl u6 nluu X U X ; aml msl u)

ulml u sXl u X (aXs nluu (X ( X o(am ax(u slam a sb sXl u) b (am;aX nluu l; ua; sbsXl u X ;ous;6 lm sb aXx a ulml u sXl u X (aXs ;Lma(;l;6 sa sb m sb ((ul u X Uou saXLosbaXlsl ; nlsblm am L X a sb m a sb sXl u) b aXx s a sbl; ;Lma(;l; m sb s a sbulml u sXl u X (aXs m ls; m oxnluu ax(uL nlsb 8 Uol ulm ; aX ;sXo soX m ams msa ulml u sXl u X (aXs)

b lm m l u l; ua;oX lmaXx slam nluu (Xakl sa b X ( osl ; m sb abm; a(tlm;(XlaX sa sXl u ( Xsl l( slam Xax uu ; m o c mk ;slU saX; nba X lmkauk lm sb sXl u m

m x am sb 9WG% aXx

L am o slmU sbl; sXl u6 sb mk ;slU saX lXx; sa b X ( osl ; sb s b aX ;b nluu x lms lm6 lm;sXl s aml m 6 lmaXx slam oXml;b L b X ( osl ; lm uo lmU s U m X s Xax sbl; sXl um (X ulxlm XL u aX saXL X ;ous;6 w (s ; w x(s aX X Uou saXL (oX(a; ;)

uu s U m X s oXlmU sb am o s a sbl; sXl u l; anm L sb (am;aX C X) kLD m x L;b X nlsb b X ( osl ; ; aosulm lm ; ( X s amsX s sn m b X ( osl ; m abm;a(tlm;)

uu x mo; Xl(s;6 ;sX s;6 aX asb X (X ; ms slam x s Xl u; m U m X s s sb l; X slam a sb(am;aX C X) kLD)

0P�us X 6 o L 6 Xs s u)6 s Xxlm ms; a ox m uu lUX slam Xa;; X lm m asb ul uuu;6 eenit %®®8 9G®CSD3++SGc+W®W

Xls tl 6 luls uua 6 u (ams 6 ( m l a; 6 u a 6 am kl ) b mslc %® xo ulsowlx lms XXo(s; sb L;X Uou s ct (( f m luf f X ;l;s m uaa( lm cuu;3 Xau lm ; m;lslF slam sa (a(sa;l;) ms m au) %®9908ICED39EI8cS+

l 6 s u)6 x( s a Xlsowlx am X u (; X s m l; lulsL lm m oXaxL ulsl; a(sln I h rt( ( tnri 9GC9®D 9%%Wr9%8®

lFFa a 6 auul 6 (l 6 s u) X k u m a m oXaxL ulsl; a(sl ;( sXox l;aX X m(b masL( l;sXl oslam) nrt %®®S0 %WE3 9IS9r9ISIu t X 6 omt 6 to; s u)6 ;slx slam a a; X TolX x ms; aX ;o;s slm i a atslklsL a sb X ( osl box m mslc %® msl a L6 r xe It t %®®G39+®38®8c89%

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