BiOS - SPIE...+1 360 676 3290 • [email protected] • twitter (#PhotonicsWest) 1 2015 SYMPOSIUM CHAIRS: BiOS is the world’s largest international biomedical optics conference, encompassing

BiOS•

CONNECTING MINDS. ADVANCING LIGHT.

Call for Papers Submit Abstracts by 28 July 2014 www.spie.org/bioscall2

The Moscone Center San Francisco, California, USA

Conferences & Courses 7–12 February 2015

Photonics West Exhibition10–12 February 2015

BIOS EXPO 7–8 February 2015

BIOS IS THE WORLD’S LARGEST BIOMEDICAL OPTICS CONFERENCE, PART OF PHOTONICS WEST

CBiOS Call for Papers

Present your work at BiOSthe world’s largest biomedical optics and biophotonics conference.

C.Call for Papers.

TECHNOLOGIES- Photonic Therapeutics and Diagnostics

- Clinical Technologies and Systems

- Nano/Biophotonics

DATESConferences & Courses: 7–12 February 2015

LOCATIONThe Moscone Center San Francisco, California, USA

- Biomedical Spectroscopy, Microscopy, and Imaging

- Tissue Optics, Laser-Tissue Interaction, and Tissue Engineering

+1 360 676 3290 • [email protected] • twitter (#PhotonicsWest) 1

2015 SYMPOSIUM CHAIRS:

BiOS is the world’s largest international biomedical optics conference, encompassing clinical, translational, and fundamental research and development in the field of biomedical optics. It provides a premier technical forum for reporting and learning about the latest research and development, as well as for launching new applications and technologies.

BiOS is part of SPIE Photonics West, the largest biophotonics, laser, optoelectronics, and industrial manufacturing event in North America, with more than 5,000 technical attendees from more than 50 countries. Special events include hot topics presentations, the BiOS Expo, focus on Translational Research, and industry leading working groups and panels.

Present your research at SPIE BiOS 2015.

James FujimotoMassachusetts Institute of Technology (USA)

R. Rox AndersonWellman Ctr. for Photomedicine, Massachusetts General Hospital (USA), and Harvard School of Medicine (USA)

Plan to Participate.

SPIE International Headquarters PO Box 10 Bellingham, WA 98227-0010 USA Tel: +1 360 676 3290 / Fax: +1 360 647 1445 [email protected] / www.SPIE.org

SPIE Europe Office 2 Alexandra Gate Ffordd Pengam, Cardiff, CF24 2SA UK Tel: +44 29 2089 4747 / Fax: +44 29 2089 4750 [email protected] / www.SPIE.org

2 SPIE PHOTONICS WEST 2015 • www.spie.org/bioscall

BiOS—BIOMEDICAL OPTICS 2015

PHOTONIC THERAPEUTICS AND DIAGNOSTICSProgram Chair: Brian J. F. Wong, Beckman Laser Institute and Medical Clinic (USA)

BO100 Photonics in Dermatology and Plastic Surgery (Choi, Kollias, Zeng) . . . . . . . . . . . .6

BO101 Therapeutics and Diagnostics in Urology (Kang) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .6

BO102 Optical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology (Wong, Ilgner, Nuttal, Richter) . . . . . . . . . . 7

BO103 Optical Techniques in Pulmonary Medicine (Suter, Lam, Brenner) . . . . . . . . . . . . . . . . . . 7

BO104 Diagnosis and Treatment of Diseases NEW in the Breast and Reproductive System

(Skala, Dewhirst) . . . . . . . . . . . . . . . . . . . . . . .8

BO105 Endoscopic Microscopy (Wang, Tearney) . . . . . . . . . . . . . . . . . . . . . 9

BO106 Diagnostic and Therapeutic Applications of Light in Cardiology (Tearney, Gregory, Marcu) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10

BO107 Optical Techniques in Neurosurgery, Brain Imaging, and Neurobiology (Hirschberg, Madsen) . . . . . . . . . . . . . . . . . .11

BO108 Neurophotonics (Jansen, Luo) . . . . . . . . . . 12

BO109 Optogenetics and Optical Control of Cells (Mohanty) . . . . . . . . . . . . . . . . . . . . 13

BO110 Optics in Bone Surgery and Diagnostics (Mandelis) . . . . . . . . . . . . . . . . . . . . . . . . . . . 14

BO111 Lasers in Dentistry (Rechmann, Fried) . . . 14

BO112 Ophthalmic Technologies (Manns, Söderberg, Ho) . . . . . . . . . . . . . . . . . . . . . . . 15

BO113 Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy (Kessel, Hasan) . 16

BO114 Mechanisms for Low-Light Therapy X (Hamblin, Carroll, Arany) . . . . . . . . . . . . . . 16

BO115 Frontiers in Biological Detection: From Nanosensors to Systems (Miller, Fauchet, Cunningham) . . . . . . . . . 17

BO116 Molecular-Guided Surgery: Molecules,NEW Devices, and Applications

(Gioux, Pogue) . . . . . . . . . . . . . . . . . . . . . . . . 17

CLINICAL TECHNOLOGIES AND SYSTEMSProgram Chairs: Tuan Vo-Dinh, Fitzpatrick Institute for Photonics, Duke Univ. (USA); Anita Mahadevan-Jansen, Vanderbilt Univ. (USA)

BO200 Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIX (Fujimoto, Izatt, Tuchin) . . . . . . . . . . . . . . . 18

BO201 Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII (Mahadevan-Jansen, Vo-Dinh, Grundfest) . . . . . . . . . . . . . . . . . . . . . . . . . . . 19

BO202 Optics and Biophotonics in NEW Low-Resource Settings (Levitz, Ozcan,

Erickson) . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20

BO203 Design and Quality for Biomedical Technologies VI (Raghavachari, Liang) . . 21

BO204 Multimodal Biomedical Imaging X (Azar, Intes) . . . . . . . . . . . . . . . . . . . . . . . . . .22

BO205 Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIV (Gannot) . . . . . . . . . . . . .23

BO206 Optical Biopsy XIII: Toward Real Time Spectroscopic Imaging and Diagnosis (Alfano, Demos) . . . . . . . . . . . . . . . . . . . . . .24

BO207 Optical Tomography and Spectroscopy of Tissue X (Tromberg, Yodh, Sevick-Muraca) . . . . . . . . . . . . . . . . . . . . . . .25

BO208 Microfluidics, BioMEMS, and Medical Microsystems XIII (Gray, Becker) . . . . . . . .26

TISSUE OPTICS, LASER-TISSUE INTERACTION, AND TISSUE ENGINEERINGProgram Chair: Steven L. Jacques, Oregon Health & Science Univ. (USA)

BO300 Optical Interactions with Tissue and Cells XXVI (Jansen, Thomas) . . . . . . . . . . . . . . . .27

BO301 Dynamics and Fluctuations in Biomedical Photonics XI (Tuchin, Leahy, Larin, Wang) . . . . . . . . . . . . . . . . . 28

BO302 Photons Plus Ultrasound: Imaging and Sensing 2015 (Oraevsky, Wang) . . . . . . . .29

BO303 Biophotonics and Immune Responses X (Chen) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30

BO304 Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue VI (Bouchard, Allen) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30


Contents .


CALL FOR PAPERS

SPIE WILL PUBLISH YOUR RESEARCH GLOBALLY · www.SPIEDigitalLibrary.orgYour work will live far beyond the conference room—all proceedings from this meeting will be published in the SPIE Digital Library. Promote yourself, your ideas, and your organization to millions of key researchers from around the world through this web-based repository of the latest technical information.

SUBMIT YOUR ABSTRACT TODAY!www.spie.org/bioscall2

BO305 Energy-Based Treatment of Tissue and Assessment VII (Ryan) . . . . . . . . . . . . . . . . . 31

BO306 Optical Elastography and Tissue Biomechanics (Larin, Sampson) . . . . . . . .32

LA115 Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XV (Heisterkamp, Herman, Meunier, Nolte) . . . . . . . . . . . . . .33

BIOMEDICAL SPECTROSCOPY, MICROSCOPY, AND IMAGINGProgram Chairs: Paras Prasad, SUNY/Univ. of Buffalo (USA); Dan V. Nicolau, McGill Univ. (Canada)

BO400 Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XII (Farkas, Nicolau, Leif) . . . . . . . . . . . . . . . . .35

BO401 Multiphoton Microscopy in the Biomedical Sciences XV (Periasamy, So, König) . . . . .37

BO402 Three-Dimensional and Multidimensional Microscopy: Image Acquisition an d Processing XXI (Brown, Cogswell, Wilson) . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38

BO403 Single Molecule Spectroscopy and Superresolution Imaging VIII (Erdmann, Enderlein, Gregor, Gryczynski, Koberling) . . . . . . . . . . . . . . . 39

BO404 Optical Diagnostics and Sensing XV: Toward Point-of-Care Diagnostics (Coté) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40

BO405 Biomedical Applications of Light Scattering X (Wax, Backman) . . . . . . . . . 40

BO406 Optical Methods in Developmental Biology III (Rollins, Lo, Fraser) . . . . . . . . . 41

BO407 Adaptive Optics and Wavefront Control for Biological Systems (Bifano, Kubby, Gigan) . . . . . . . . . . . . . . . .42

BO408 Quantitative Phase Imaging NEW (Popescu, Park) . . . . . . . . . . . . . . . . . . . . . . .43

NANO/BIOPHOTONICSProgram Chairs: Ammasi Periasamy, Univ. of Virginia; Daniel L. Farkas, Univ. of Southern California

BO500 Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications X (Cartwright, Nicolau) . . . . . . . . . . . . . . . . . 44

BO501 Colloidal Nanoparticles for Biomedical Applications IX (Parak, Osiński, Liang) . .45

BO502 Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications (Achilefu, Raghavachari) . . 46

BO503 Plasmonics in Biology and Medicine XI (Vo-Dinh, Lakowicz) . . . . . . . . . . . . . . . . . .47

BO504 Bioinspired, Biointegrated, Bioengineered Photonic Devices III (Yun, Rogers, Lee) . . . . . . . . . . . . . . . . . . . .48

TRANSLATIONAL RESEARCH . . . . . . . . . . . . . . . . . 49

3D PRINTING . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49

General Information . . . . . . . . . . . . . . . . . . . . . . . . . . 50

Submission of Abstracts . . . . . . . . . . . . . . . . . . . . . . . 51

BiOS EXPO . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .52


Abstracts Due: 28 JULY 2014

EXECUTIVE ORGANIZING COMMITTEESamuel Achilefu, Washington Univ. School of

Medicine in St. Louis (USA)Robert Alfano, The City College of New York

(USA)David Allen, National Institute of Standards and

Technology (USA)Praveen Arany, National Institute of Dental and

Craniofacial Research (USA)Fred Azar, Philips Healthcare (USA)Vadim Backman, Northwestern Univ. (USA)Holger Becker, microfluidic ChipShop GmbH

(Germany)Thomas Bifano, Boston Univ. (USA)Jean-Pierre Bouchard, INO (Canada)Matthew Brenner, Univ. of California, Irvine (USA)Thomas Brown, Univ. of Rochester (USA)James Carroll, THOR Photomedicine Ltd. (United

Kingdom)Alexander Cartwright, Univ. at Buffalo (USA)Wei Chen, Univ. of Central Oklahoma (USA)Bernard Choi, Beckman Laser Institute and

Medical Clinic (USA)Carol Cogswell, Univ. of Colorado at Boulder

(USA)Gerard Coté, Texas A&M Univ. (USA)Brian Cunningham, Univ. of Illinois at Urbana-

Champaign (USA)Stavros Demos, Lawrence Livermore National Lab.

(USA)Mark Dewhirst, Duke Univ. (USA)Jörg Enderlein, Georg-August-Univ. Göttingen

(Germany)Rainer Erdmann, PicoQuant GmbH (Germany)David Erickson, Cornell Univ. (USA)Daniel Farkas, Univ. of Southern California (USA)Philippe Fauchet, Vanderbilt Univ. (USA)Scott Fraser, California Institute of Technology

(USA)Daniel Fried, Univ. of California, San Francisco

(USA)James Fujimoto, Massachusetts Institute of

Technology (USA)Israel Gannot, Tel Aviv Univ. (Israel)Sylvain Gigan, Institut Langevin (France)Sylvain Gioux, Beth Israel Deaconess Medical Ctr.

(USA)Bonnie Gray, Simon Fraser Univ. (Canada)Ingo Gregor, Georg-August-Univ. Göttingen

(Germany)Kenton Gregory, Oregon Medical Laser Ctr. (USA)Warren Grundfest, Univ. of California, Los Angeles

(USA)Zygmunt Gryczynski, Univ. of North Texas Health

Science Ctr. at Fort Worth (USA)

Michael Hamblin, Wellman Ctr. for Photomedicine (USA)

Tayyaba Hasan, Massachusetts General Hospital (USA)

Henry Hirschberg, Beckman Laser Institute and Medical Clinic (USA)

Arthur Ho, Brien Holden Vision Institute (Australia)Justus Ilgner, Univ. Hospital Aachen (Germany)Xavier Intes, Rensselaer Polytechnic Institute

(USA)Joseph Izatt, Duke Univ. (USA)E. Duco Jansen, Vanderbilt Univ. (USA)Hyun Wook Kang, Pukyong National Univ. (Korea,

Republic of)David Kessel, Wayne State Univ. (USA)Felix Koberling, PicoQuant GmbH (Germany)Nikiforos Kollias, Consultant (USA)Karsten König, Univ. des Saarlandes (Germany)Joel Kubby, Univ. of California, Santa Cruz (USA)Joseph Lakowicz, Univ. of Maryland School of

Medicine (USA)Stephen Lam, The BC Cancer Agency Research Ctr.

(Canada)Kirill Larin, Univ. of Houston (USA)Martin Leahy, National Univ. of Ireland, Galway

(Ireland)Luke Lee, Univ. of California, Berkeley (USA)Robert Leif, Newport Instruments (USA)Ofer Levi, Univ. of Toronto (Canada)David Levitz, MobileOCT (Israel)Rongguang Liang, College of Optical Sciences,

The Univ. of Arizona (USA)Xing-Jie Liang, National Center for Nanoscience

and Technology (China)Cecilia Lo, Univ. of Pittsburgh (USA)Qingming Luo, Britton Chance Ctr. for Biomedical

Photonics (China)Steen Madsen, Univ. of Nevada, Las Vegas (USA)Anita Mahadevan-Jansen, Vanderbilt Univ. (USA)Andreas Mandelis, Univ. of Toronto (Canada)Fabrice Manns, Univ. of Miami (USA)Laura Marcu, Univ. of California, Davis (USA)Benjamin Miller, Univ. of Rochester Medical Ctr.

(USA)Samarendra Mohanty, The Univ. of Texas at

Arlington (USA)Dan Nicolau, McGill Univ. (Canada)Robert Nordstrom, National Cancer Institute

(USA)Alfred Nuttal, Oregen Health and Science Univ.

(USA)Alexander Oraevsky, TomoWave Laboratories, Inc.

(USA)Marek Osiński, The Univ. of New Mexico (USA)Aydogan Ozcan, Univ. of California, Los Angeles

(USA)

BIOS—THE WORLD’S LARGEST BIOMEDICAL OPTICS CONFERENCE

4 SPIE PHOTONICS WEST 2015 • www.spie.org/bioscall2

CALL FOR PAPERS

Wolfgang Parak, Philipps-Univ. Marburg (Germany)

YongKeun Park, KAIST (Korea, Republic of)Ammasi Periasamy, Univ. of Virginia (USA)Brian Pogue, Thayer School of Engineering at

Dartmouth (USA)

Gabriel Popescu, Univ. of Illinois at Urbana-Champaign (USA)

Ramesh Raghavachari, U.S. Food and Drug Administration (USA)

Peter Rechmann, Univ. of California, San Francisco (USA)

Claus-Peter Richter, Northwestern Univ. (USA)John Rogers, Univ. of Illinois at Urbana-Champaign

(USA)Andrew Rollins, Case Western Reserve Univ.

(USA)Thomas Ryan, ArthroCare Corp. (USA)David Sampson, The Univ. of Western AustraliaEva Sevick-Muraca, The Univ. of Texas Health

Science Ctr. at Houston (USA)Melissa Skala, Vanderbilt Univ. (USA)Peter So, Massachusetts Institute of Technology

(USA)Per Söderberg, Uppsala Univ. (Sweden)Melissa Suter, Massachusetts General Hospital

(USA)Guillermo Tearney, Wellman Ctr. for

Photomedicine (USA)Nitish Thakor, Johns Hopkins Univ. (USA)Robert Thomas, Air Force Research Lab. (USA)Bruce Tromberg, Beckman Laser Institute and

Medical Clinic (USA)Valery Tuchin, N.G. Chernyshevsky Saratov State

Univ. (Russian Federation)Tuan Vo-Dinh, Fitzpatrick Institute for Photonics,

Duke Univ. (USA)Lihong Wang, Washington Univ. in St. Louis (USA)Ruikang Wang, Univ. of Washington (USA)Thomas Wang, Univ. of Michigan (USA)Adam Wax, Duke Univ. (USA)Tony Wilson, Univ. of Oxford (United Kingdom)Brian J. Wong, Beckman Laser Institute and

Medical Clinic (USA)Arjun Yodh, Univ. of Pennsylvania (USA)Seok Hyun Yun, Harvard Univ. (USA)Haishan Zeng, The BC Cancer Agency Research

Ctr. (Canada)


IMPORTANT DATESAbstracts Due: 28 JULY 2014BiOS Manuscript Due Date: 12 JANUARY 2015

PLEASE NOTE: Submissions imply the intent of at least one author to register, attend the conference, present the paper as scheduled, and submit a full-length manuscript for publication in the conference proceedings.


PHOTONIC THERAPEUTICS AND DIAGNOSTICS

Photonics in Dermatology and Plastic Surgery IV (BO100)Conference Chairs: Bernard Choi, Beckman Laser Institute and Medical Clinic (USA); Nikiforos Kollias, Consultant (USA); Haishan Zeng, The BC Cancer Agency Research Ctr. (Canada)

Program Committee: Anthony J. Durkin, Beckman Laser Institute and Medical Clinic (USA); Iltefat Hamzavi M.D., Henry Ford Hospital (USA); Kristen Marie Kelly M.D., Univ. of California, Irvine School of Medicine (USA); Jessica C. Ramella-Roman, The Catholic Univ. of America (USA); Lise Lyngsnes Randeberg, Norwegian Univ. of Science and Technology (Norway); Tsung-Hua Tsai, Far Eastern Memorial Hospital (Taiwan)

The research and development of highly selective lasers has transformed the clinical practice of der-matology and plastic surgery by allowing vascular lesions, pigmented lesions, tattoos, and hair to be removed without scarring. These important exam-ples of selective photothermal injury continue to be refined and extended. The potential for laser or non-laser applications in skin diagnosis, imaging, and treatment for burns and other conditions such as pso-riasis, acne, and vitiligo far exceeds their present use.

A detailed understanding of skin optics, photother-mal, photoacoustic, and photobiological processes is emerging. Innovative schemes for delivery and control of laser irradiation, including robotics, can potentially improve therapy. Optical spectroscopy, microscopy, and imaging techniques hold significant promises in skin lesion diagnosis and skin therapy monitoring, and submissions in these areas are especially welcome.

New laser therapeutics, including burn treatment, fractional laser technology, wound healing, drug delivery and photodynamic therapy of inflamma-tory skin conditions and cancer, will also be topics of interest for this session. Laser/tissue interaction, therapeutics, and diagnostics relating to light and skin, as well as competing technologies in the same scope, are also invited.

Contributions from all medical, dental, and veterinary specialties, military-related applications, and basic sciences contributions are encouraged. Presentations that focus on translational research in dermatology and plastic surgery are also welcomed.

Therapeutics and Diagnostics in Urology (BO101)Conference Chairs: Hyun Wook Kang, Pukyong National Univ. (Korea, Republic of)

Program Committee: Geoffrey N. Box M.D., The Ohio State Univ. (USA); Kin Foong Chan, Dermira, Inc. (USA); Nathaniel M. Fried, The Univ. of North Carolina at Charlotte (USA); Babak Shadgan M.D., The Univ. of British Columbia (Canada); Ronald Sroka, Laser-Forschungslabor (Germany); Joel M. Teichman M.D., St. Paul’s Hospital (Canada); Matthias Trottmann, Univ. München (Germany) Rudolf M. Verdaasdonk, Vrije Univ. Medical Ctr. (Netherlands)

This era of high technology in urology includes many new and routine uses of lasers for treatment and diagnosis. In addition, the use of light for both photodiagnostic purposes and photodynamic ther-apy continues to move from research lab to clinical use. Laser applications assisted with robotic devices enable high precision tissue cutting and ablation during surgery. Other energy-based treatments are also being applied for tissue destruction in urology.

This conference covers the use of lasers and thermal technology for treatment and diagnosis in urology and provides an opportunity to share ideas and technical information among scientists, engineers, and clinicians.

Papers are solicited in urological applications of therapeutic and diagnostic modalities including, but not limited to, the following:

LASERS FOR PHOTOTHERAPEUTICS• Fundamental laser-cell/tissue interactions in

urological applications• Laser coagulation/ablation/resection of tumors

in bladder, kidney, ureter, and renal pelvis• Photodynamic therapy of upper and lower

urinary tracts• Lithotripsy with lasers, shockwave, high-

intensity focused ultrasound (HIFU), and pneumatic systems

OTHER ENERGY FORMS FOR TISSUE TREATMENT• Minimally invasive surgical techniques including

radio frequency, microwave, HIFU, cryo, plasma, and irreversible electroporation (IRE)

• Tissue treatment effects and healing responses during energy-based treatments

TISSUE IMAGING FOR DIAGNOSTICS• Cellular/molecular imaging, probing, and optical

biopsy in urology• Pre-clinical/clinical applications of optical

imaging including optical coherence tomography (OCT), photoacoustic tomography (PAT), fluorescence, polarization, confocal, spectroscopy, microscopy, and photodynamic diagnosis (PDD)

• MRI, CT, PET, ultrasound, and terahertz imaging for detection of urological diseases

ADVANCED TECHNOLOGY IN UROLOGY• Novel designs and applications of optical fibers

and endoscopic delivery devices• Robotic-assisted surgery including radical

prostatectomy and nephrectomy• 3-D modeling and simulation on surgical procedures• Optical nerve stimulation for dysfunctional

urinary systems• Nanoparticle-assisted and image-guided therapy.


CALL FOR PAPERS

Optical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology (BO102)

Optical Techniques in Pulmonary Medicine (BO103)Conference Chairs: Melissa J. Suter, Massachusetts General Hospital (USA); Stephen Lam M.D., The BC Cancer Agency Research Ctr. (Canada); Matthew Brenner, Univ. of California, Irvine (USA)

Program Committee: Johannes de Boer, Vrije Univ. Amsterdam (Netherlands); Edmund Koch, Universitätsklinikum Carl Gustav Carus Dresden (Germany); David D. Sampson, The Univ. of Western Australia (Australia); Luc Thiberville, Rouen Univ. Hospital (France); Victor X. D. Yang, Ryerson Univ. (Canada); Septimiu D. Murgu M.D., The Univ. of Chicago (USA); Robert A. McLaughlin, The Univ. of Western Australia (Australia)

Due to the high prevalence of lung diseases and the lack of available technologies to adequately evaluate the complex processes of the respiratory system, the use of optical techniques for studying, diagnosing, and treating the pulmonary airways has rapidly increased in recent years. While the application of optical technologies in pulmonary medicine is an emerging trend, scientists in this field are working towards developing new, and advancing existing, optical technologies for disease detection, diagnosis, and treatment, and for guiding and evaluating pul-monary interventions. In addition, these techniques are being utilized to study respiratory physiology and pathophysiolgy including airway structure and function relationships such as perfusion, ventilation, mechanics and re-modeling.

This conference will cover all aspects relating to optical based molecular, structural and functional imaging, diagnosis, and treatment of the lung. The goal is to bring together scientists and clinicians to discuss and progress current state-of-the-art optical diagnostic and therapeutic techniques, and to use the developed optical approaches to challenge and further develop our current understanding of the physiology and pathophysiology of the respiratory system.

Topics include:• optical techniques for assessing bronchial and

alveolar lung structure• optical evaluation of pulmonary function:

perfusion, ventilation, mechanics and re-modeling

• optical diagnostics• evaluation of normal and diseased/injured

airway• optical detection, evaluation of treatment• optical coherence tomography• diffuse optical tomography• confocal and two-photon microscopy• spectroscopy• optical molecular imaging• fluorescence imaging• optical imaging and activation of inhaled agents• novel bronchoscopy techniques• laser/radiofrequency ablation treatment

techniques• optical monitoring of therapeutics.

IN CONJUNCTION WITH:

Conference Chairs: Brian J. F. Wong M.D., Beckman Laser Institute and Medical Clinic (USA); Justus F. Ilgner M.D., Univ. Hospital Aachen (Germany); Alfred Nuttal, Oregen Health and Science Univ. (USA); Claus-Peter Richter, Northwestern Univ. (USA)

Program Committee: Christian S. Betz, Ludwig-Maximilians-Univ. München (Germany); Waseem K. Jerjes, Univ. College London (United Kingdom); Milind Rajadhyaksha, Memorial Sloan-Kettering Cancer Ctr. (USA); Chung-Ku Rhee M.D., Dankook Univ. Hospital (Korea, Republic of); Jennifer E. Rosen, Boston Univ. (USA); Henricus J. C. M. Sterenborg, Erasmus MC (Netherlands)

Otolaryngology and head and neck surgery is a fertile field for applications of emerging technolo-gies. Precise focused beams and advanced energy delivery systems provide the foundation for the development of innovative microsurgical techniques. Optical spectroscopic diagnostics, including elastic scattering, differential path-length, fluorescence and infrared spectroscopy, enhance tissue differentiation and identification. Interferometric and stroboscopic optical techniques such as OCT (optical coherence tomography) can be used to monitor motion of the vocal folds and/or of the tympanic membrane. Diag-nostic systems increasingly interact with robotic and/or master-slave devices to allow for high precision cutting and ablation. Progress in OCT technology and other areas is facilitated successfully by inter-actions among clinicians, scientists, engineers, and researchers.

This conference covers the use of lasers and optical technology in otolaryngology and head and neck surgery, and provides an informative and crucial face-to-face interaction between the basic scientist and the clinician: a win-win scenario.

Papers from clinicians, scientists, engineers, and manufacturers are solicited in the following medical subspecialty areas:• imaging of the vocal cords and airway• cochlear imaging• femtosecond laser surgery applications• CO2 laser ablation• middle ear surgery/Stapes surgery• endoscopic cancer resection• RF surgical applications• plasma-mediated ablation• robotic and master / slave systems• optical diagnostic techniques• laryngology and speech science• translational research.



Diagnosis and Treatment of Diseases in the Breast and Reproductive System (BO104) New

Conference Chairs: Melissa C. Skala, Vanderbilt Univ. (USA); Mark W. Dewhirst D.V.M., Duke Univ. (USA)

Program Committee: Ji-Xin Cheng, Purdue Univ. (USA); Darren M. Roblyer, Boston Univ. (USA); Anita Mahadevan-Jansen, Vanderbilt Univ. (USA); Bruce J. Tromberg, Beckman Laser Institute and Medical Clinic (USA)

An array of optical technologies have been developed to diagnose and treat reproductive diseases in men and women. The great specificity of light provides an opportunity to identify pathologies such as can-cer (prostate, ovarian, cervical, breast, testicular), infertility, and pre-term labor. Treatments for these diseases can also be monitored over time using min-imally invasive optical technologies. Collaborations between clinicians, engineers, and scientists are par-amount to develop and translate these technologies.

This conference intends to bring together researchers and clinical partners to present and discuss advances in optical technologies in breast and reproductive health. Topics span fundamental understanding and discovery to preclinical and clinical applications. The intent is to stimulate interactions that will contribute to future progress in developing both basic science and translational technologies.

Technologies include but are not limited to the following:• diffuse optical imaging• fiber optic probe development• functional and anatomical imaging• microscopy• multi-modal imaging• optical coherence tomography• pptical methods to assess tissue structure,

biomechanics, and function• optical contrast agent development• photodynamic therapy• photoacoustic imaging• Raman, fluorescence, and absorption

spectroscopy

Applications include but are not limited to the fol-lowing:• breast cancer• cervical cancer• ovarian cancer• prostate cancer• testicular cancer• benign prostatic hypertrophy• fetal oxygen monitoring• in vitro fertilization• infertility• maternal health• optical studies of the breast and reproductive

system in animal models• optical studies of the breast and reproductive

system in vitro• pre-term labor• translational research.


CALL FOR PAPERS

Endoscopic Microscopy (BO105)

Conference Chairs: Guillermo J. Tearney M.D., Wellman Ctr. for Photomedicine (USA); Thomas D. Wang, Univ. of Michigan (USA)

Program Committee: David L. Dickensheets, Montana State Univ. (USA); Arthur F. Gmitro, The Univ. of Arizona (USA); Ralf Kiesslich M.D., Johannes Gutenberg Univ. Mainz (Germany); Francois Lacombe, Mauna Kea Technologies (France); Stephen Lam M.D., The BC Cancer Agency Research Ctr. (Canada); Hiroshi Mashimo, VA Boston Healthcare System (USA); Kenzi Murakami, Olympus Corp. (Japan); Norman S. Nishioka M.D., Massachusetts General Hospital (USA); Wibool Piyawattanametha, National Electronics and Computer Technology Ctr. (Thailand); Mark J. Schnitzer, Stanford Univ. School of Medicine (USA); Peter T. C. So, Massachusetts Institute of Technology (USA); Melissa J. Suter, Massachusetts General Hospital (USA)

Papers for this session focus on the development of high resolution imaging systems that are endoscope compatible and include novel techniques for early detection, screening, diagnosis, intervention, and treatment of disease in either pre-clinical models or human subjects. In general, remote detection is based on the use of an optical fiber to transmit light between the instrument and the tissue, and involves the collection of information about molecular and cellular processes without physical excision of tissue. These methods of in vivo optical imaging extends across a wide range of resolution, from molecular, sub-cellular and cellular to tissue and organ levels. The creation of an image may require a variety of different scanning mechanisms.

Endoscopic techniques provide unique advantages over other (e.g. whole body) imaging modalities for evaluating disease present over the epithelial surface of hollow organs. The direct proximity of collection optics to regions of disease can result in unparalleled achievement of resolution, unraveling of molecular mechanisms, and use of fluorescence contrast agents. Examples of applications of endo-scopic microscopy to medicine include the detection of pre-malignant lesions, identification of disease below the tissue surface, assessment of depth of tumor invasion, localization of cancer margins, eval-uation of effectiveness of pharmacological therapy, and reduction in number of physical biopsies and frequency of surveillance.

This conference provides an inter-disciplinary fo-rum for physicians, molecular biologists, chemists, biochemists, optical engineers, and instrument designers to report and discuss recent results, im-provements, and new approaches in the emerging field of endoscopic microscopy.

Contributed papers are solicited concerning, but not limited to, the following areas:• confocal microendoscopy• multi-photon microendoscopy• endoscopic OCT• endoscopic OCM• fluorescence endoscopic imaging• video capsule endoscopy• endocytoscopy• high magnification endoscopy• light scattering spectroscopy• Raman spectroscopy• infrared spectroscopy• MEMS scanning mechanisms• micro-actuators• luminal optical contrast agents• endoscopic image processing and analysis.

JOINT SESSIONThis special joint session is in conjunction with the OPTO conference on MOEMS and Miniaturized Systems (OE119). Papers are solicited that address the unique challenges to deliver high-fidelitymicroscopic imaging of tissue with a miniaturized instrument platform. Example topics include mechanisms for distal beam scanning, focus control and aberration correction using MOEMS devices, MEMS actuators or electrowetting op-tics; proximal scanning based on DMD or other SLM technologies; novel optical assembly and alignment techniques; highly corrected miniature optical systems.



Diagnostic and Therapeutic Applications of Light in Cardiology (BO106)

Conference Chairs: Guillermo J. Tearney M.D., Wellman Ctr. for Photomedicine (USA); Kenton W. Gregory M.D., Oregon Medical Laser Ctr. (USA); Laura Marcu, Univ. of California, Davis (USA)

Program Committee: Gijs van Soest, Erasmus MC (Netherlands); Carlo Di Mario, Univ. College London (United Kingdom); Stanislav Y. Emelianov, The Univ. of Texas at Austin (USA)

During the last decade there have been significant scientific developments in the diagnosis and treat-ment of cardiovascular diseases using lasers and optical technology. Recent progress in vulnerable plaque detection has motivated the development of a variety of new optical techniques for intra-coronary diagnosis. The scientific and medical communities have additionally continued to search for new technologies and to improve on existing technologies that can be applied to areas such as cardiovascular recanalization or angioplasty, welding of vascular anastomoses, ablation of arrhythmogenic foci, transmyocardial revascularization, etc. The interdisciplinary research and collaboration among physicians, scientists, engineers, and manufacturers is paramount to maintaining and strengthening the field of biomedical cardiovascular laser applications.

This conference intends to bring together researchers and industry partners to present and discuss the im-portant advances in laser and diagnostic applications in cardiovascular medicine. The intent is to stimulate interactions, which will contribute to future progress in developing effective clinical cardiovascular diag-nostic and therapeutic systems.

Topics will include, but are not limited to, the fol-lowing:• new laser sources for transmyocardial laser

revascularization• mechanisms of laser revascularization• ablation of arrhythmogenic foci and bypass

pathways• excimer laser applications• ablative and nonablative applications• catheter design for laser therapy of arrhythmias• evaluation of available laser angioplasty devices• new fibers and catheter designs for laser

angioplasty• new lead extraction laser catheters• optical methods of assessing cardiovascular

structure, biomechanics and function• vascular welding• vascular reactivity to laser energy

• approaches to control and assess the extent of laser injury

• new applications for laser thrombolysis• spectroscopy• fluorescence spectroscopy and imaging• new catheter design for intravascular optical

diagnostics• photodynamic therapy• photodynamic therapy for intimal hyperplasia• MEMS for cardiovascular diagnostics• optical coherence tomography• Raman, fluorescence, and absorption

spectroscopy• angioscopy• thermography• optical studies of the cardiovascular system in

animal models• contrast agents for cardiovascular diagnosis and

therapy• cardiovascular optogenetics• translational research.


CALL FOR PAPERS

Optical Techniques in Neurosurgery, Brain Imaging, and Neurobiology (BO107)

Conference Chairs: Henry Hirschberg M.D., Beckman Laser Institute and Medical Clinic (USA); Steen J. Madsen, Univ. of Nevada, Las Vegas (USA)

Program Committee: David Abookasis, Ariel Univ. of Samaria (Israel); Frederic Leblond, Ecole Polytechnique de Montréal (Canada); Herbert Stepp, Ludwig-Maximilians-Univ. München (Germany); Pablo A. Valdes, Dartmouth College (USA); Victor X. D. Yang, Ryerson Univ. (Canada)

Recent technological advances have opened excit-ing opportunities for lasers and optical techniques in neurosurgery and brain imaging. Therapeutic applications include: tumor debulking/removal via thermal or photochemical interactions, and spinal decompression and discectomy. Optical techniques have also shown promise in a number of diagnostic applications, including fluorescence-guided tumor resection, imaging of cortical function and intra-vas-cular examinations. Of special interest is the use of optical or other imaging modalities in the detection and therapy of neuro-degenerative diseases such as Alzheimer’s or Parkinson’s.

The purpose of this conference is to provide a forum for clinicians, scientists, engineers and manufacturers to report on current developments and to discuss future opportunities for optical techniques in neu-rosurgery and brain imaging.

Contributed papers are solicited concerning, but not limited to, the following areas:• laser surgery in the brain and spine• fluorescence-guided resection• optical spectroscopy of normal brain and

neoplastic tissue• functional imaging of the brain using optical

techniques• photodynamic therapy in neurosurgery• optical instrumentation and devices, including

microscopes and endoscopes• optical localization and registration techniques

for neuronavigation• fMRI/PET• techniques for in vivo microscopy• microscopic imaging and advanced microscopic

techniques• virtual reality• real-time functional imaging in the OR• co-registration (optical and other imaging

modalities)• translational research.





Neurophotonics (BO108)

Conference Chairs: E. Duco Jansen, Vanderbilt Univ. (USA); Qingming Luo, Huazhong Univ. of Science and Technology (China)

Conference Co-Chairs: Jun Ding, Stanford School of Medicine (USA); Anna W. Roe, Vanderbilt Univ. (USA)

Program Committee: David A. Boas, Massachusetts General Hospital (USA); Yu Chen, Univ. of Maryland, College Park (USA); Javier DeFelipe, Univ. Politécnica de Madrid (Spain); Hongwei Dong, Univ. of California, Los Angeles (USA); Congwu Du, Stony Brook Univ. (USA); Beop-Min Kim, Korea Univ. (Korea, Republic of); Vesa Kiviniemi, Univ. of Oulu (Finland); Pengcheng Li, Britton Chance Ctr. for Biomedical Photonics (China); Anita Mahadevan-Jansen, Vanderbilt Univ. (USA); Francesco Saverio Pavone, European Lab. for Non-linear Spectroscopy (Italy); Kambiz Pourrezaei, Drexel Univ. (USA); Claus-Peter Richter, Northwestern Univ. (USA); Shy Shoham, Technion-Israel Institute of Technology (Israel); Vladislav Toronov, Ryerson Univ. (Canada); Shaoqun Zeng, Britton Chance Ctr. for Biomedical Photonics (China)

Neurophotonics bridges optical physics and neu-roscience. Neurons are the basic building blocks of the nervous system and study of neuronal structure, function and behavior forms the basis of understand-ing and manipulating neural activity. Conventional methods in the research laboratory as well as in the clinic rely on electrical methods for stimulating, modulating and recording neural activity. The past decade has seen the rise of optical methods in this domain. Direct stimulation of neural cells and tissues using (laser) light has seen tremendous interest in the past few years. For example, infrared light was used to stimulate neural activity in the peripheral and central nervous system. Light-based technologies with different wavelengths from the UV through the infrared have been applied to stimulate neural tissue and cells. Therefore, the discussion on the mechanism of the light induced neural activation can be initiated. Novel optically inducible ion channels such as the -opsins for neural targeting, present an additional dimension to this area of research and opportunities for cross-fertilization of research ideas.

Genomics and proteomics have opened up an era providing new approaches and new tools for neuro-science research, particularly in optical neuroimag-ing. “Function follows form”, anatomic structure is the basis for understanding the brain’s function and brain diseases. Brain function depends on neuronal networks and so from a systems biology perspective, should be studied not only the neuron level, but also at the neuronal networks and system levels. Optical imaging can now be applied at multiple levels from gene to molecular, from cellular to tissue and from organ to system levels to yield critical information bridging molecular structure and physiological function.

The purpose of this conference is to provide a forum for scientists, clinicians, engineers and manufactures to report current developments and to discuss future opportunities for optical stimulating, modulating, manipulating, detecting, or imaging the brain or neural circuits at the gene, molecular, cellular, tissue, organ, or system level, in physiology and anatomy.

Topics will include, but are not limited to, the fol-lowing:

NOVEL PHOTONIC OR OPTOELECTRONIC METHODS• photon-neuron interaction, modulating,

manipulating neural activity and/or interfacing with the central nervous system

• infrared neural stimulation (INS)• optogenetics: optical activation of neurons

(genetically targeted light activated ion channels)

• detecting brain swelling or neural/seizure activity

• holographic neural stimulation and other approaches to spatial-temporal patterning.

OPTICAL NEUROIMAGING• high resolution optical imaging of synaptic

physiology, in vivo and/or in vitro neural circuits and networks

• diffusion, fluorescence and polarization spectroscopies, optical coherence tomography, Doppler, photo acoustics, speckle, or optical intrinsic signal imaging for brain cortex activity and neurovascular physiology

• functional near-infrared imaging (fNIRI) for human brain activity, such as working memory

• diffusive optical tomography for animal or human brain studies

• optical imaging of brain-wide neuroanatomical architecture or connectivity

• brain models and specimen preparation including mouse, treeshrew, marmoset, monkey, or human brain

• optical reporters, markers, dyes, nanoparticles, and molecular probes for brain models or neuronal circuits

• segmentation, identification and visualization of brain-wide dataset

• multimodal imaging integrating structural and functional information.

APPLICATIONS• optical neural prosthetics• nerve conduction• therapeutic interventions• feedback control• diagnosis of nerve dysfunction• pain control and modulation• traumatic brain injury• neural regeneration• artificial neurons.


CALL FOR PAPERS

Optogenetics and Optical Control of Cells (BO109)

These include:

APPLICATIONS OF OPTOGENETIC MODULATION• neural modulation for medical applications• controlling stem cell activity and their

differentiation• manipulation of Cardiac and other excitatory

cellular systems• reprogramming of metabolic activities• dissection of neural circuitry: functional

connectomics• modulation of other cellular functions.

OPTICAL IMAGING AND DETECTION OF CELLULAR STIMULATION• scattering/absorption based functional imaging

during optical stimulation• calcium probes and voltage-sensitive dye-based

imaging• in vivo fiber-based imaging and monitoring of

opsin expression• other novel optical imaging of physiological

activity.

BIOPHYSICS AND SPECTROSCOPIC CHARACTERIZATION OF OPSINS• characterization of opsins by FTIR, Raman and

other opticalspectroscopic methods• elucidation of the molecular structure of opsins

by crystallography• novel electrophysiological evaluation methods• modeling of opsin-photocycle.

NOVEL SOURCES FOR OPTOGENETIC STIMULATION• two-photon optogenetics• spatially and temporally modulated beams• waveguides and light delivery methods for in-

vivo applications• µLED array based devices for prosthetic

applications• modeling propagation of stimulating light in

tissue.

NEW OPSINS AND DELIVERY METHODS FOR OPTOGENETICS• functionally-improved opsins with enhanced

spectral and electrical properties• viral vectors and new expression strategies• optically-controlled delivery and gene

expression• advanced combinatorial optogenetic probes.

OTHER EMERGING HYBRID OPTICAL TECHNOLOGIES• photochemical stimulation• optoelectric activation• optofluidic manipulation• photothermal stimulation.

Conference Chairs: Samarendra K. Mohanty, The Univ. of Texas at Arlington (USA); Nitish V. Thakor, Johns Hopkins Univ. (USA)

Program Committee: Antoine Adamantidis, McGill Univ. (Canada); George J. Augustine, Duke-NUS Graduate Medical School (Singapore); Isaac P. Clements, Plexon Inc. (USA); Klaus B. Gerwert, Ruhr-Univ. Bochum (Germany); Xue Han, Boston Univ. (USA); Elizabeth M. Hillman, Columbia Univ. (USA); Richard Kramer, Univ. of California, Berkeley (USA); Alfred L. Nuttall, Oregon Health & Science Univ. (USA); Anna W. Roe, Vanderbilt Univ. (USA); Ulrich T. Schwarz, Fraunhofer Ctr. for Applied Photonics (Germany); John P. Welsh, Univ. of Washington (USA); Rafael Yuste M.D., Columbia Univ. (USA)

By combining genetic and optical methods, “optoge-netics” has allowed control (stimulation or silencing) of electrically-activatable, genetically-targeted cells with high temporal precision. This has heavily impact-ed neuroscience research by allowing dissection of functioning of neuronal circuitry. Since its first in-vivo demonstration, optogenetics technology has been applied to freely moving mammals and could even-tually form the basis of treatments of neurological disorders such as for vision restoration, psychiatric treatment and pain-control. Optogenetic technology is also impacting other biomedical research areas such as for control of cardiac function, stem cell differentiation and reprogramming of metabolic activities in mammalian cells. In all of these settings, optics is playing a crucial role in both delivering light for cellular control, and in some cases for imaging the consequences of this control. The introduction of non-linear optics has further allowed very precise and in-depth spatial control of optogenetic stimu-lation. Though fiber optic and waveguide technol-ogy is enabling delivery of light to targeted tissue regions, other photonic imaging technologies have the potential to significantly contribute to imaging read-outs of neural/cellular activities during opto-genetic stimulation (e.g. intravital microscopy, dif-fuse-reflectance, fluorescence, and SHG etc.). While a detailed understanding of tissue optics is essential for delivery of stimulation light, use of crystallography and spectroscopic methods will enhance the under-standing of the interaction processes between light and optogenetic molecules.

Innovative schemes for delivery and control of light irradiation, including miniaturized light source, fiber optics, waveguides and special beams can potentially improve optogenetic therapy. Optical microscopy, spectroscopy, and imaging techniques hold significant promise for characterizing opto-genetic probes and submissions in these areas are especially welcome. New therapeutic applications, including control of central and peripheral nervous system, cardiac system, stem cells as well as control of metabolic activities will also be topics of interest for this conference. Contributions from all biomed-ical specialties and basic sciences are encouraged. Technical and scientific papers related to advance-ment in development of optogenetics probes, their characterization, and applications, as well as other emerging hybrid optical technologies, coupled with new imaging and detection modalities are solicited.



Optics in Bone Surgery and Diagnostics (BO110)Conference Chairs: Andreas Mandelis, Univ. of Toronto (Canada)

Conference Co-Chairs: Michael D. Morris, Univ. of Michigan (USA)

Program Committee: Robert R. Alfano, The City College of New York (USA); Bennett T. Amaechi, The Univ. of Texas Health Science Ctr. at San Antonio (USA); Peter Fratzl, Max-Planck-Institut für Kolloid- und Grenzflächenforschung (Germany); Huabei Jiang, Univ. of Florida (USA); Stephen J. Matcher, The Univ. of Sheffield (United Kingdom); Eleftherios P. Paschalis, Ludwig Boltzmann Institut (Austria); Rahul Tandon D.D.S., Loma Linda Univ. (USA); Victor X. D. Yang, Ryerson Univ. (Canada)

With the penetration of lasers, optics, and imaging techniques in the field of tissue diagnostics, a rapid growth in bone-related biophotonics and optics-aid-ed bone surgery has emerged. While x-ray bone di-agnostics and imaging are well established photonic techniques due to their deep sub-dermal penetration, bone research has been associated more with endo-scopic technologies for which light waves face serious penetration barriers. However, we are witnessing an explosion in optical probes and diagnostics of bones and bone disease in the last 4-7 years.

This conference emphasizes optical applications to bone biology and surgery. It targets interdisciplinary research reports which bring out the interactions of bone with photons including relevant energy conver-sion mechanisms (ultrasound, heat) and can be used as a forum for the cross-fertilization and advance-ment of the science and technologies associated with bone optics and photonics. Technical and scientific papers related to the interactions and studies of bones with photons with energies spanning the entire spectral range from gamma rays to microwave and millimeter waves are solicited.

These include:• mineral density, mechanical strength, strain,

optical and other bone property measurements using optical absorption, reflection, transmission and scattering techniques

• optics in bone biology• optics guided bone surgery• optical topographical imaging• gamma - and x-ray imaging and bone

densitometry• general bone radiography• bone applications of ultrafast laser techniques• advanced optical techniques for the study of

bones and osteopathologic processes: optical coherence tomography, terahertz, photoacoustic and photothermal detection and spectroscopy, diffuse photon techniques

• bone spectroscopies, microscopies and diagnostic instrumentation

• in-vitro and in-vivo imaging and tomographies• fluorescence imaging and emission tomography• transdermal optics and bone osteogenesis

imaging• optics in bone endoscopy and surgery• bone optical engineering and clinical systems• non-linear effects in bone-photon interactions.• optically-guided treatment of bone trauma• bone tissue ablation with lasers• bone grafting: autogenous, allografts, xenografts• dental osseointegration into bone.

Lasers in Dentistry XXI (BO111)Conference Chairs: Peter Rechmann, Univ. of California, San Francisco (USA); Daniel Fried, Univ. of California, San Francisco (USA)

Program Committee: Gregory B. Altshuler, Palomar Medical Technologies, Inc. (USA); Tatjána Dostálová M.D., Charles Univ. in Prague (Czech Republic); John D. Featherstone, Univ. of California, San Francisco (USA); David M. Harris, Bio-Medical Consultants, Inc. (USA); Harvey A. Wigdor D.D.S., Advocate Illinois Masonic Medical Ctr. (USA)

Laser applications for dental hard tissue are a clinical reality. Exciting future applications are being de-veloped and will be featured at this conference. An entire session will be devoted to lesion detection by optical methods. This is one of the areas of rapidly ex-panding interest in dental research and applications to clinical practice, especially in relation to dental caries. Soft tissue clinical applications continue to be expanded. This conference will provide a forum for presentation of both basic and applied research in laser dentistry. Presentations of clinical studies are especially welcome. Manuscripts will be reviewed prior to publication.

Papers are solicited in all dental laser and biomedical optics dental application areas including, but not limited to, the following:• optical methods for lesion detection, especially

dental caries• early caries detection• optical coherence tomography in dentistry• dental 3D imaging• caries removal with lasers• caries prevention with lasers• laser endodontics• laser applications in periodontology• lasers and dental implants• laser photopolymerization• laser hard-tissue and soft tissue surgery• CO2 laser use in dentistry• Nd: YAG laser use in dentistry• Diode laser use in dentistry• Er: YAG/ErCr: YSGG use in dentistry• other wavelengths for hard or soft tissue use• clinical trials of lasers for dental applications• hard-tissue ablation and plasma production• laser-tissue interactions relevant to dentistry• wavelength and energy dependence of dental

laser applications• translational research.


CALL FOR PAPERS

Ophthalmic Technologies XXV (BO112)

Conference Chairs: Fabrice Manns, Univ. of Miami (USA); Per G. Söderberg, Uppsala Univ. (Sweden); Arthur Ho, Brien Holden Vision Institute (Australia)

Program Committee: Rafat R. Ansari, NASA Glenn Research Ctr. (USA); Michael Belkin, Tel Aviv Univ. (Israel); Kostadinka Bizheva, Univ. of Waterloo (Canada); David Borja, Alcon Labs., Inc. (USA); Ralf Brinkmann, Univ. zu Lübeck (Germany); Wolfgang Drexler, Medizinische Univ. Wien (Austria); Daniel X. Hammer, U.S. Food and Drug Administration (USA); Karen M. Joos, Vanderbilt Univ. (USA); Kirill V. Larin, Univ. of Houston (USA); Ezra Maguen, American Eye Institute (USA); Donald T. Miller, Indiana Univ. (USA); Daniel V. Palanker, Stanford Univ. (USA); Jean-Marie Parel, Bascom Palmer Eye Institute (USA); Roberto Pini, Istituto di Fisica Applicata Nello Carrara (Italy); Luigi Rovati, Univ. degli Studi di Modena e Reggio Emilia (Italy); Georg Schuele, OptiMedica Corp. (USA); Jerry Sebag, The Univ. of Southern California (USA); Peter Soliz, VisionQuest Biomedical, LLC (USA); Valery V. Tuchin, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)

You are invited to submit papers to Ophthalmic Tech-nologies XXV - the premier international meeting on therapeutic and diagnostic technology in the field of ophthalmology, which brings together engineers and scientists developing the next innovations, and clinicians and practitioners extending the technology.

Some recent topics covered include:• ophthalmic diagnostics• ophthalmic applications of OCT• adaptive optics• retinal prosthesis and bionic vision• wavefront sensing and wavefront-guided

surgery• laser surgical systems• femto second laser applications• artificial cornea and keratoprostheses• optoacoustic monitoring• functional and molecular imaging of the eye• imaging of retinal and choroidal vasculature• selective retinal photocoagulation• optics of the eye and vision correction• ocular biometrics• ocular diagnostics of neural diseases• virtual reality in ophthalmology• optics and laser applications in ophthalmic drug

delivery.

SPECIAL ABSTRACT REQUIREMENTS: PEER REVIEWSubmissions to this conference must include the following three separate documents:• 100-word text abstract (for online program)• 250-word text abstract (for abstract digest)• 2-page extended abstract (for committee

review only) The extended abstract is limited to two pages, including tables and figures. Include author names and affiliations; text; any figures, tables, or images; and sufficient data to permit peer review. All submissions will be peer-reviewed by the Program Committee to determine acceptance. The best extended abstracts will

be nominated for the Pascal Rol Award. Extended abstracts will be used only for the purpose of peer review, and will not be published.

NOTE ON DUPLICATE ABSTRACTSAuthors who submit an abstract on a similar topic for presentation at another BiOS conference may be invited to present a short communication that should focus on ophthalmic issues.

PASCAL ROL AWARD 2015Outstanding extended abstracts submitted to the Ophthalmic Technologies XXV conference will be nominated for the Pascal Rol Award for Best Paper in Ophthalmic Technologies. The award and prize will be presented after the last scientific session of the conference to recognize the best paper and presentation. The 2014 recipient of the Pascal Rol Award was Dr. Marco Ruggeri and his colleagues from the University of Miami (see www.pascalrolfoundation.org).

SPECIAL PRESENTATIONUnmet Ophthalmic Technology NeedsThis presentation series was established to pro-mote the exchange of ideas between clinicians with a technological need and engineers inter-ested in solving problems in ophthalmology. The invited lecture is sponsored by the Pascal Rol Foundation (www.pascalrolfoundation.org). The 2015 invited speaker will be Prof. Zoltan Nagy from Semmelweiss University in Budapest, Hungary, on the topic of femtosecond laser cataract surgery.



Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV (BO113)Conference Chairs: David H. Kessel, Wayne State Univ. (USA); Tayyaba Hasan, Massachusetts General Hospital (USA)

Program Committee: Charles J. Gomer, Children’s Hospital Los Angeles (USA); Nancy L. Oleinick, Case Western Reserve Univ. (USA); Ravindra K. Pandey, Roswell Park Cancer Institute (USA); Brian W. Pogue, Thayer School of Engineering at Dartmouth (USA); Kenneth K. Wang M.D., Mayo Clinic (USA)

Photodynamic therapy (PDT) has been approved by health agencies in several countries for treatment of neoplasia in a variety of sites and has been used for treatment of other pathologic conditions including actinic keratosis, atherosclerosis, and age related macular degeneration (AMD). PDT can be used to tar-get different subcellular sites for photodamage, e.g., the endoplasmic reticulum, lysosomes, mitochondria, and the plasma membrane. Photodamage can elicit cell death by activation of apoptosis, circumventing many common modes of drug resistance.

This conference will emphasize drug development, mechanisms, clinical applications, instrumentation for light delivery and dosimetry determinations along with new information on photodynamic mechanisms.

Abstracts are encouraged dealing with these topics:• drug development and characterization• clinical protocols and outcomes• mechanisms of phototoxicity• techniques for light delivery and dosimetry• tissue optics.

Mechanisms for Low-Light Therapy X (BO114)Conference Chairs: Michael R. Hamblin, Wellman Ctr. for Photomedicine (USA); James D. Carroll, THOR Photomedicine Ltd. (United Kingdom); Praveen Arany, National Institute of Dental and Craniofacial Research (USA)

Program Committee: Juanita Anders, Uniformed Services Univ. of the Health Sciences (USA); Tomas Hode, Immunophotonics, Inc. (USA); Daniel Barolet M.D., McGill Univ (Canada)

Low levels of visible light (frequently red or near-in-frared) can have significant therapeutic effects on multiple classes of diseases, injuries and medical dis-orders. In particular it is effective for wound healing and pain control as well as reduction of inflammation and swelling.

It is believed that the primary cellular chromophore that absorbs low levels of red and near-infrared light is cytochrome c oxidase, which is located in mitochondria. This absorption of energy may lead to increase in ATP synthesis and release of reactive oxygen species from the electron transport chain that can subsequently activate transcription factors and lead to cell proliferation and migration.

Despite many reports of positive findings from ex-periments conducted in vitro, in animal models and in randomized controlled clinical trials, LLLT remains controversial. This likely is due to two main reasons; firstly the biochemical mechanisms underlying the positive effects are incompletely understood, and secondly the complexity of rationally choosing amongst a large number of illumination parameters such as wavelength, fluence, power density, pulse structure and treatment timing has led to the pub-lication of a number of negative studies as well as many positive ones.

This conference covers a field that is rapidly achiev-ing a general level of acceptance in the medical and biomedical communities and will cover all of the important areas of LLLT research.

Contributed papers are solicited in the following areas (among others):• mechanistic studies and cellular chromophores• development of light sources for LLLT (LED

photomodulation; pulsed IR light therapy)• study of LLLT dosimetry• in vitro research in mammalian cells• in vitro research in micro-organisms in culture• stimulation of wound healing and scar reduction

in animal models• nerve regeneration and neural stimulation• prevention of ischemia-induced tissue death and

regeneration.

Well-controlled clinical trials in the following areas:• stimulation of wound healing such as non-

healing ulcers• treatments for stroke and degenerative brain

disease• pain reduction in post-surgical and neuralgia

patients• dental applications• dermatology applications• reduction of pain and inflammation in arthritis

and other orthopedic conditions• macular degeneration prevention• reduction of edema.


CALL FOR PAPERS

Frontiers in Biological Detection: From Nanosensors to Systems (BO115)Conference Chairs: Benjamin L. Miller, Univ. of Rochester Medical Ctr. (USA); Philippe M. Fauchet, Vanderbilt Univ. (USA); Brian T. Cunningham, Univ. of Illinois at Urbana-Champaign (USA)

Program Committee: Xudong Fan, Univ. of Michigan (USA); Laura Maria Lechuga, Catalan Institute of Nanoscience and Nanotechnology (Spain); Frances S. Ligler, U.S. Naval Research Lab. (USA); Michael J. Sailor, Univ. of California, San Diego (USA); Oliver G. Schmidt, Leibniz-Institut für Festkörper- und Werkstoffforschung Dresden (Germany); Christopher C. Striemer, Adarza BioSystems, Inc. (USA); Sharon M. Weiss, Vanderbilt Univ. (USA)

Detection of biological materials, from DNA strands to whole pathogens, is increasingly becoming a concern throughout society, not only in diagnostic laboratories in hospitals but also for on-site uses by health care providers or soldiers. From monitoring incidence of drug-resistant bacteria in hospitals and detecting harmful pathogens for homeland security to ensuring that our food is safe and our water clean, new, simple, inexpensive, sensitive, and fast methods of identifying biological molecules and pathogens are a pressing need. Optical solutions promise to provide many of these advantages and as a result many platforms for optical detection are being demonstrated in the laboratory. The deployment of bio-detection systems however requires that strin-gent specifications be met, for example in terms of sensitivity, false-positive and false-negative assess-ments, automated sample processing and analysis, system design and integration, and low cost.

This conference seeks to gather scientists, engineers and users active in biological detection. Contributions are sought in all areas, from novel optical detection platforms to nanosensors to system integration and commercialization.

Topics of interest include but are not limited to:• new sensing platforms• ultrasensitive (single pathogen) detection

methods• utilization of nanomaterials and new optically

responsive materials for pathogen detection• miniaturized optic components such as

microring resonators, photonic crystals, integrated optical waveguides, and nanoparticles

• label-free vs. tagged detection systems• organic and inorganic platforms• probe design• strategies to eliminate non-specific binding• integration of optics and microfluidics• systems demonstrations• new applications for environmental, medical,

and food testing.

A portion of the symposium will focus on optical sensors and diagnostics for the developing world; submissions in this topic area are particularly en-couraged.

Molecular-Guided Surgery: Molecules, Devices, and Applications (BO116)Conference Chairs: Brian W. Pogue, Thayer School of Engineering at Dartmouth (USA); Sylvain Gioux, Beth Israel Deaconess Medical Ctr. (USA)

Program Committee: Hak Soo Choi, Beth Israel Deaconess Medical Ctr. (USA); David J. Cuccia, Modulated Imaging, Inc. (USA); Daniel R. Draney, LI-COR Biosciences (USA); Hisataka Kobayashi, National Cancer Institute (USA); Vasilis Ntziachristos, Helmholtz Zentrum München GmbH (Germany); Keith D. Paulsen, Thayer School of Engineering at Dartmouth (USA); Jonathan M. Sorger, Intuitive Surgical, Inc. (USA); Tomasz S. Tkaczyk, Rice Univ. (USA); Alex Vahrmeijer, Leiden Univ. Medical Ctr. (Netherlands); Thomas D. Wang M.D., Univ. of Michigan (USA); Brian C. Wilson, Ontario Cancer Institute (Canada); Siavash Yazdanfar, GE Global Research (USA)

Advanced optical-molecular imaging applied to sur-gical guidance has emerged over the last decade as a major sector of Biomedical Optics with a growing impact and increasing numbers of clinical devices and procedures. Molecular-guided surgery relies on imaging specific markers in vivo, whether exogenous (e.g. fluorescence) or endogenous (e.g. hemoglobin), and allows healthcare practitioners to visualize features and function of tissue, in addition to the standard anatomical structures. This field requires a broad range of expertise including instrumentation, chemistry, biology, physics, tracer kinetics and clin-ical translation.

The number of investigators working in this specific field has grown from just a few individuals to hun-dreds of research groups today. This new conference aims to consoildate related work into one forum with the goals of pooling expertise and allowing the com-munity to follow and contribute to the field’s progress while offering strong potential for discussions and collaborations.

Submissions are solicited in the following and related areas:• contrast agents and molecular probes• devices and methods – fluorescence imaging• devices and methods – endogenous imaging• preclinical applications• clinical translation• clinical applications.

New


CLINICAL TECHNOLOGIES AND SYSTEMS

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIX (BO200)

Conference Chairs: James G. Fujimoto, Massachusetts Institute of Technology (USA); Joseph A. Izatt, Duke Univ. (USA); Valery V. Tuchin, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)

Program Committee: Peter E. Andersen, Technical Univ. of Denmark (Denmark); Kostadinka Bizheva, Univ. of Waterloo (Canada); Stephen A. Boppart M.D., Univ. of Illinois at Urbana-Champaign (USA); Zhongping Chen, Beckman Laser Institute and Medical Clinic (USA); Johannes de Boer, Vrije Univ. Amsterdam (Netherlands); Wolfgang Drexler, Medizinische Univ. Wien (Austria); Christoph K. Hitzenberger, Medizinische Univ. Wien (Austria); Robert A. Huber, Univ. zu L¸beck (Germany); Rainer A. Leitgeb, Medizinische Univ. Wien (Austria); Xingde Li, Johns Hopkins Univ. (USA); Yingtian Pan, Stony Brook Univ. (USA); Adrian Gh. Podoleanu, Univ. of Kent (United Kingdom); Andrew M. Rollins, Case Western Reserve Univ. (USA); Natalia M. Shakhova, Institute of Applied Physics (Russian Federation); Guillermo J. Tearney M.D., Wellman Ctr. for Photomedicine (USA); Ruikang K. Wang, Univ. of Washington (USA); Maciej Wojtkowski, Nicolaus Copernicus Univ. (Poland); Yoshiaki Yasuno, Univ. of Tsukuba (Japan)

SPECIAL ABSTRACT REQUIREMENTS: PEER REVIEWSubmissions to this conference are due no later than 4 August 2014 (one week after the main BiOS due date) and must include the following:• 100-word text abstract (for online program)• 250-word text abstract (for abstract digest)• 3-page summary (for committee review)

Optical coherence tomography and other optical methods and instruments based on coherent light interactions with tissues and detection methods are promising for noninvasive medical diagnostics and monitoring a wide spectrum of pathologies as well as fundamental biomedical research. The focus of this conference will be on the physical and mathematical basis of coherence domain methods, new instru-mentation and techniques and their applications in biomedical science and clinical practice. Directions of research and development in areas such as opti-cal coherence tomography (OCT), low-coherence interferometry, speckle and speckle interferometry measurement and imaging technologies, polarized light diagnostic methods, coherent light microscopy, and coherence technologies for flow and functional imaging will be considered. Applications of coher-ence domain optical methods for biological studies and clinical applications will also be discussed.

Papers are solicited on the following and related topics:• optical coherence tomography (OCT) systems,

theory, image processing techniques in OCT• spectral/Fourier domain and swept source OCT• optical coherence microscopy (OCM) full-field

OCT• molecular, spectroscopic and functional OCT• Doppler and polarization-sensitive OCT• OCT angiography• phase-contrast techniques• novel light sources for OCT• imaging devices and probes for OCT• low-coherence interferometry and topography• white-light interferometry• novel contrast mechanisms• clinical applications of OCT• ophthalmic applications• cardiovascular and intravascular applications• cancer imaging• endoscopic imaging• small animal imaging• developmental biology.


CALL FOR PAPERS

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII (BO201)

Oral and poster sessions are planned in the following subject areas:

CLINICAL DIAGNOSTIC SYSTEMS• minimally invasive diagnostics systems based

on Fluorescence, Raman scattering, diffuse reflectance

• early screening applications• clinical monitoring of early pathological or

physiological states• multi-modality diagnostic systems (optics

combined with acoustic, ultrasound, MRI, PET, X-ray)

• component/system design, engineering, and performance of biomedical instruments

• microinstrumentation and miniaturized clinical systems

• integrated instrument systems• high throughput systems.• digital pathology• automated data analysis algorithms• point-of-care diagnostics• diagnostics for personalized medicine

ADVANCED SENSORS FOR MEDICINE• clinical applications of optical biosensors

(enzyme, antibody, gene probe-based systems)• physical sensors and chemical in vivo sensors• biochip technologies• bio-electrics and nanosecond pulsing

technology• sensors for burn diagnostics• advances in assay automation and delivery

technology.

MEDICAL IMAGING TECHNIQUES AND DEVICES• Fluorescence, IR, OCT and other optical imaging

systems• advanced endoscopy techniques and devices• smart catheters• laser radar sensing and imaging• RF radar imaging• terahertz techniques and systems (imaging,

spectroscopy, and modeling)• optical methods of assessing structure and

function• trauma and critical care• telemedicine, telesurgery• virtual reality technologies.

MEDICAL GUIDANCE SYSTEMS• image guidance• tracking technology (optical, acoustic, etc.)• stereotactic technology• catheter navigation• anatomical identification• tumor demarcation, margin identification• therapeutic assessment• dexterity-enhanced surgery• robotics-assisted surgery• surgical simulators• real-time feedback systems• virtual reality techniques.

Conference Chairs: Anita Mahadevan-Jansen, Vanderbilt Univ. (USA); Tuan Vo-Dinh, Fitzpatrick Institute for Photonics, Duke Univ. (USA); Warren S. Grundfest M.D., Univ. of California, Los Angeles (USA)

Program Committee: Maurice C. Aalders, Forensic Technical Solutions (Netherlands); Francesco Baldini, Istituto di Fisica Applicata Nello Carrara (Italy); Jennifer K. Barton, The Univ. of Arizona (USA); Stephen A. Boppart M.D., Univ. of Illinois at Urbana-Champaign (USA); Gerald Grant, Duke Univ. (USA); Hong Liu, The Univ. of Oklahoma (USA); Laura Marcu, Univ. of California, Davis (USA); Mary-Ann Mycek, Univ. of Michigan (USA); Jianan Y. Qu, Hong Kong Univ. of Science and Technology (Hong Kong, China); Urs Utzinger, The Univ. of Arizona (USA); Georges A. Wagnières, Ecole Polytechnique Fédérale de Lausanne (Switzerland); Christopher W. Woods M.D., Duke Univ. (USA); Pixuan ‘Joe’ Zhou, DMetrix, Inc. (USA)

As surgical systems and clinical diagnostics adapt to new methods, instrumentation and assay tech-nology, the pace of system innovations continues to accelerate. Many technologies originally developed for other applications, e.g., defense, energy, and aerospace, have found applications in the medical industry/environment. This conference provides a forum for scientists, engineers, manufacturers, and clinical providers to present the most recent advances in instrumentation and methods of diag-nostic and therapeutic guidance systems for clinical applications. The conference goal is to provide an interdisciplinary forum for state-of-the-art methods in instrumentation research and development of biomedical technologies, approaching the trans-lation from research and development prototypes to user application. The emphasis will be on clinical translation and implementation. The conference will address the interests of researchers, applied scientists, engineers, and clinicians whose goal is to implement clinical systems with extended, improved performance capabilities.

Papers are sought that describe the methodologies, instrumentation systems and analysis of biomedical optics technologies for clinical implementation. Topics will span the areas of instrumentation, system engineering, assay automation, delivery technology, and data management for biomedical diagnostics and surgical assistance in the clinical setting in de-veloped countries as well as in developing countries. Examples include stereotactic systems developed for brain surgery, flexible micronavigation devices engineered for medical laser ablation treatments, re-al-time monitoring system of critical function, online sensing of biological assays, and digital pathology.



Optics and Biophotonics in Low-Resource Settings (BO202)

New

Conference Chairs: David Levitz, MobileOCT (Israel); Aydogan Ozcan, Univ. of California, Los Angeles (USA); David Erickson, Cornell Univ. (USA)

Program Committee: Gerard L. Coté, Texas A&M Univ. (USA); Frances S. Ligler, North Carolina State Univ. (USA); Anita Mahadevan-Jansen, Vanderbilt Univ. (USA); Nirmala Ramanujam, Duke Univ. (USA); Avi Rasooly, National Institutes of Health (USA); Eric A. Swanson, OCT News (USA); Sebastian Wachsmann-Hogiu, NSF Ctr. for Biophotonics Science and Technology (USA); Ian M. White, Univ. of Maryland, College Park (USA)

Approximately 85 % of the world’s population (6 billion people) lives outside OECD nations, where resources and facilities available to deliver medical care are limited. Optical technologies are uniquely positioned to enable emerging economies to improve the delivery of healthcare of their people. Optical methods can non-invasively assess the microstruc-ture, function, and composition of tissues, as well as deliver targeted therapies. The revolution in digital electronics has significantly reduced both the price and size of components (sensors, light sources, computing units) critical to most optical systems. Integrating such optical components with compact microfluidics and low-cost biomarkers allows for building robust optical systems that are inexpensive and scalable.

This conference is designed to serve as a forum for those engineers, scientists, clinicians, and aid workers who are developing and delivering bio-photonics-based solutions for healthcare delivery in low- resource settings. An emphasis is placed on mobility, cost-effectiveness, energy efficiency, and scalability, in pursuit of the ultimate goal of clinical validation and transitioning to the field.

Topics include:• smartphone-based imaging, sensing and

diagnostics systems• mobile and miniature optical systems• design adaptation for low-resource settings• integrated optics and microfluidics• translational research in low-resource settings• low-cost optical and optically-guided

therapeutics• spectroscopy and spectral imaging• low-cost optomechanical design• energy efficient systems• algorithms for mobile image analysis• machine learning and computer vision for mobile

imaging and sensing systems• contrast agents for field-use or point-of-care• mobile confocal and coherence-domain imaging• polarization-based mobile imaging and/or

detection methods.

The paper you present will live far beyond the conference roomAll proceedings from this event will be published in the SPIE Digital Library, promoting breakthrough results, ideas, and organizations to millions of key researchers from around the world.

www.SPIEDigitalLibrary.org

Helping engineers and scientists stay current and competitive


CALL FOR PAPERS

Design and Quality for Biomedical Technologies VII (BO203)

• illumination and detection geometry for imaging and spectroscopic systems

• fiber optic imaging systems• novel optical sensing and detection• micro-optics and MEMS based optical systems• sources, detectors and other components• maximum permissible light exposure levels in

vivo• development, validation, and application of

computer-aided design tools.

III. QUALITY• maximum permissible light exposure levels in

vivo• Quality by Design (QbD)• device calibration and intercomparison• standards in biomedical imaging and

spectroscopy• standards in devices and components• standards in image/data processing and storage• phantoms and test methods• metrology• development/evaluation of novel measurement

tools• computer-aided diagnosis algorithms• critical metrics for assessing quality• quality, compliance and regulatory issues related

to biomedical devices• statistical approaches for designing, evaluating,

and validating medical device, databases, and technologies

• patient and user safety; photothermal, biochemical, etc.

IV. RELIABILITY• physics, analysis, failure mechanisms and testing

for failure• aging, dormancy and component degradation• computational and analytical modeling• determination of factors of safety• reusability of new optical devices.

V. BIOMEDICAL IMAGING TECHNOLOGIES• hyperspectral, spectroscopic techniques• image enhancing techniques• CMOS technologies for biomedical applications• multi-modal techniques, including hybrid

devices with non-optical (e.g., x-ray, MRI, ESR, ultrasound) components

• small animal imaging• molecular imaging• digital Imaging and telemedicine.

JOINT SESSIONA special joint session is planned with the Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue (BO304) conference.

Conference Chairs: Ramesh Raghavachari, U.S. Food and Drug Administration (USA); Rongguang Liang, College of Optical Sciences, The Univ. of Arizona (USA)

Conference Co-Chairs: T. Joshua Pfefer, U.S. Food and Drug Administration (USA)

Program Committee: Anthony J. Durkin, Beckman Laser Institute and Medical Clinic (USA); Kenji Taira, Olympus Corp. (USA); Jeeseong Hwang, National Institute of Standards and Technology (USA); Stephen P. Morgan, The Univ. of Nottingham (United Kingdom); Robert J. Nordstrom, National Institutes of Health (USA); Jannick P. Rolland, Univ. of Rochester (USA); Eric J. Seibel, Univ. of Washington (USA); Tomasz S. Tkaczyk, Rice Univ. (USA); Gracie Vargas, The Univ. of Texas Medical Branch (USA); Rudolf M. Verdaasdonk, Vrije Univ. Medical Ctr. (Netherlands); David W. Allen, National Institute of Standards and Technology (USA)

Rapid advances in optical technologies and compu-tational power have brought about a revolution in biomedical diagnostics and therapeutics. However, these advances necessitate parallel progresses in techniques used for development and evaluation.

This conference will focus on three key areas that are critical to the design and production of safe, ef-fective, and commercially-viable biomedical devices and technologies:1. systems and components which require unique

solutions for biomedical applications2. the evaluation of quality and safety of

biomedical imaging devices and technologies3. the establishment of device reliability, including

failure and performance degradation.

This conference provides a unique forum for scien-tists and engineers from academia, industry and government to discuss issues that are relevant to all biomedical imaging modalities. Interactions between these parties should facilitate the development of biomedical devices and evaluation methods that will benefit medical/biological knowledge and patient care. Submissions pertaining to optical diagnostics and therapeutics for all fields of medicine as well as optical evaluation of pharmaceuticals and biotech-nology products are solicited for this conference.

I. DEVICES• optical and biophotonic devices and instruments

for research and clinical applications• biosensor, noninvasive photonics medical

sensors• biomedical instrumentation• image guided biopsy, surgical and therapeutic

device and technologies• cost effective optics and devices• preclinical, in vivo-simulating device, and

technologies.

II. DESIGN• tomography, polarization, confocal,

multispectral, multiphoton, spectroscopic, and multimodal imaging systems

• optics for biomedical imaging technologies and devices



Multimodal Biomedical Imaging X (BO204)

The conference objectives are to provide a forum:• to review and share recent developments in

novel multimodal imaging techniques,• to report development of novel computational

methods, and• to bring together the optical imaging and image

analysis communities.

Topics include, but are not limited to:• multimodal imaging integrating structural,

molecular and functional information• multimodal microscopic imaging• 2D, 3D, 4D tomographic and / or multi-spectral

imaging• imaging analysis and/or image processing

techniques applied to optical imaging (e.g. visualization, segmentation, registration)

• multimodal imaging instrumentation and system design

• detection and diagnostic analysis techniques which may provide better quantitative and/or diagnostic insight into clinical and pre-clinical imaging (e.g. methods for quantitative measurements, computer-assisted diagnosis)

• imaging analysis and/or image processing techniques used to combine optical imaging with other imaging modalities (e.g. MR, x-ray, PET)

• iImage analysis, computational methods and reconstruction approaches which may help bring optical imaging into the clinic (visual rendering of complex data set, novel algorithms for assisted optical reconstruction)

• clinical evaluation of these new technologies (physiological and functional interpretation of image data, visual perception and observer performances, validation of quantitative assessment of optical signatures in-vivo).

Conference Chairs: Fred S. Azar, Philips Medical Systems (USA); Xavier Intes, Rensselaer Polytechnic Institute (USA)

Program Committee: Caroline Boudoux, Ecole Polytechnique de Montréal (Canada); Christophe Chefd’hotel, Ventana Medical Systems, Inc. (USA); Yu Chen, Univ. of Maryland, College Park (USA); Qianqian Fang, Massachusetts General Hospital (USA); Sergio Fantini, Tufts Univ. (USA); Gultekin Gulsen, Univ. of California, Irvine (USA); Theodore J. Huppert, Univ. of Pittsburgh (USA); Tim Nielsen, Philips Research (Germany); Vasilis Ntziachristos, Helmholtz Zentrum München GmbH (Germany); Brian W. Pogue, Thayer School of Engineering at Dartmouth (USA); Siavash Yazdanfar, GE Global Research (USA); Arjun G. Yodh, Univ. of Pennsylvania (USA)

Optical techniques offer the potential to contribute greatly to the expansion of clinical multimodality techniques. Their ability to image structural, func-tional, and molecular information at different spatial and temporal scales makes them very attractive to the biomedical community. There is critical need for new instrumental approaches and computational techniques to provide rapid, accurate and cost-ef-fective means for acquisition, quantification and characterization of multimodal data. Multimodality approach can be understood as the combination of multiple optical techniques in an instrument and/or fusion of an optical technique with other well-estab-lished imaging modalities such as CT, MRI, US, or PET. These instrumental and computational methods will enable faster acceptance of novel imaging modalities into viable clinical and/or pre-clinical systems. The applications are diverse and range from imaging at the cellular level to the whole body while incorporat-ing molecular, functional and anatomical information.


CALL FOR PAPERS

Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XV (BO205)

• 1D, 2D, 3D photonic bandgap crystals• new surgical and diagnostic procedures based

on optical fibers and waveguides • fiber based methods and systems • imaging bundles for the VIS/NIR/MIR • embedded optical sensors • imaging capsules • bio-compatibility of fiber materials for

endoscopic tools • mechanical properties of fibers (bending, tensile

strength) for endoscopic applications • new fibers and catheter designs for laser surgical

applications • sensor and detector arrays • sensors for the smart medical home• sensors for remote rural areas • trans-endoscopic optical methods such as

Optical Coherent Tomography (OCT), confocal, Bragg sensing.

The aim of the conference is to bring together groups of researchers, applied scientists, engineers, clinicians, students and industrialists belonging to different disciplines who have as a common link the development and use of optical sensing and fiber based techniques and methodologies. We aim to create a synergistic environment for discussion and growth of the field.

The conference subject is particularly suitable to obtain the right balance among the various disci-plines. To this aim, the papers should report on both technical and biomedical advances. Contributions focusing on the development of fibers, endoscopic delivery, and diagnostic systems sensing methods for applications in all biomedical areas are solicited.

Conference Chairs: Israel Gannot, Tel Aviv Univ. (Israel)

Program Committee: JJames P. Clarkin, Polymicro Technologies, A Subsidiary of Molex Incorporated (United States); Ilko Ilev, U.S. Food and Drug Administration (United States); Jin U. Kang, Johns Hopkins Univ. (United States); Karl-Friedrich Klein, Technische Hochschule Mittelhessen (Germany); Pierre Lucas, The Univ. of Arizona (United States); Yuji Matsuura, Tohoku Univ. (Japan); Angela B. Seddon, The Univ. of Nottingham (United Kingdom)

Optical components, devices and systems, both passive and active, operating in the ultra-violet (UV), visible (VIS), near-infrared (NIR) and mid-IR (MIR) spectral regions (but not limited to these), for use in: medical sensing, early disease diagnosis, disease monitoring and medical treatment and surgery. Com-ponents, devices and systems including: waveguides and waveguide sensors, Lab-on-Chip, light delivery devices, passive fibers, bright sources such as fibre lasers and supercontinuum generation, bundles, detectors, - these are essential elements needed to perform biological and clinical laboratories and in-vivo medical procedures for the 21st century. This conference will cover various topics in these fields.

In the medical field there are still pressing demands for the following:• new fibers and waveguides, other delivery

devices, and trans-endoscopic tools for the X-ray, UV, VIS, NIR and MIR regions of the spectrum

• invasive minimal invasive and non-invasive optical, biological, environmental and chemical sensors for UV/VIS/NIR/MIR fluorescence, Raman, absorption and evanescent-wave and photo-thermal spectroscopy, optical, and thermal bundles- biosensors for the medical and biological

areas - fiber sensors for physical, chemical, and

immunoassays - waveguide sensors, including molecular

diagnostic arrays • covering an increasing number of laser output

wavelengths – such as ultrafast lasers, X-ray lasers, and UV/VIS/NIR/MIR fiber lasers

• Femto, Atto, Zepto and Yocto pulse delivery • low loss waveguides and fiber bundles for

Terahertz, thermal, and optical imaging • theory of waves and signals delivery in fibers • fiber damage thresholds for high energy pulse

delivery, nonlinear effects • making the therapeutic and diagnostic systems

more intelligent and safer, i.e., by increasing the number and the role of fiber based and control devices in the diagnostic and surgical apparatus - this will lead to safer operative procedures for both patients and physicians

• smart surgical tools • optical fiber and waveguide materials and

devices required specifically for medical applications





Optical Biopsy XIII: Toward Real Time Spectroscopic Imaging and Diagnosis (BO206)

• phosphorescence spectroscopy and imaging• novel coherence methods• multi photon spectroscopy and imaging• upper excite states for deeper penetration in

tissue and brain• time resolved spectroscopy and imaging• speckle and spatial Fourier frequencies

spectroscopy for diagnoses• ultraviolet diagnostic methods• infrared diagnostic methods• optical biopsy mapping with linear excitation

methods• nonlinear optical biopsy mapping• instrumentation for in-vivo optical biopsy• video spectral imaging and mapping of tissue• nano particle tagging and contrast agents• chemo- and molecular targeting agents• STED nano-scale imaging• supercontinuum for medical and biological

applications• noninvasive detection and imaging of cancer• diabetes noninvasive detection• assessment of tissue injury• high resolution imaging methods for in vivo

pathology• instrumentation of in vivo optical biopsy• in vivo spectroscopy and imaging• endoscopes and micro-endoscopes for optical

biopsy• tissue modification with light pulses• laser tissue welding and real time monitoring• integration of optical detection and therapy

systems• dynamics of laser-tissue interactions• novel methods for optical biopsy.• “optical metabolomics” maybe a future growth

area.

Conference Chairs: Robert R. Alfano, The City College of New York (USA); Stavros G. Demos, Lawrence Livermore National Lab. (USA)

Program Committee: Irving J. Bigio, Boston Univ. (USA); Nicole J. Crane, Naval Medical Research Ctr. (USA); Zhiwei Huang, National Univ. of Singapore (Singapore); Amir Gandjbakhche, National Institutes of Health (USA); Israel Gannot, Tel Aviv Univ. (Israel); Igor V. Meglinski, Univ. of Otago (New Zealand); Yang Pu, Univ. of California, Irvine (USA); Milind Rajadhyaksha, Memorial Sloan-Kettering Cancer Ctr. (USA); Kestutis Sutkus, The City College of New York (USA); Siavash Yazdanfar, GE Global Research (USA)

The goal of this conference is to present novel state-of-the-art work in non-invasive spectroscopic methods to detect the onset and progression of disease, including pre-malignancy and malignancy, and tissue and cells response to external conditions, including therapeutic intervention, unintended injury, and laser energy deposition. The conference will focus on work investigating the differences in single and multiphoton excitation optical signatures of normal and diseased tissues, and on understanding the underlying biochemical and structural changes of tissues and cells responsible for the observed spectroscopic signatures. It is worth noting that this symposium has hosted in recent years a number of contributions on the detection of disease using optical spectroscopy signatures of body fluids such as urine or blood plasma. As the field of metabolo-mics continues to grow, it is possible that “optical metabolomics” maybe a new frontier in the field of Optical Biopsy.

This conference covers a wide array of well-estab-lished optical techniques and novel approaches to diagnose tissues changes, including: in vivo and ex vivo fluorescence spectroscopy, Stokes shift spec-troscopy, spectral imaging, Raman spectroscopy, multiphoton and photonic methods to modify the tissue and body fluids properties or functions imple-mented in vivo or ex-vivo covering the technology development steps from bench-to-bedside. Compact pill smart spectral explorers, multi-spectral imagers, coherence effects, and hyper spectral imaging will be highlighted and covered, in part, by speakers.

Topics include:• origin of tissue optical properties• NIR optical windows in 700 nm to 2500nm• optical methods for tissue diagnosis and

treatment• methods for in vivo assessment of physiological

state of tissue• excitation, absorption, fluorescence

spectroscopy and imaging• Raman spectroscopy and imaging• inelastic light scattering spectroscopy and

imaging• stimulated Raman gain spectroscopy and

imaging• Stokes shift spectroscopy• polarization and diffusive reflectance spectral

imaging• THz spectroscopy and imaging


CALL FOR PAPERS

Optical Tomography and Spectroscopy of Tissue XI (BO207)

This conference emphasizes all aspects of diffuse optical methods in tissues, including novel hardware and instrumentation, modeling and computation, and applications in human subjects and pre-clinical models.

Suggested topics include the following:• non-invasive spectroscopy and imaging of

normal brain function, neuro-degeneration, brain trauma, and neuro-pathologies

• non-invasive functional spectroscopy and imaging of skeletal-muscular systems, including joints, bones, and muscle

• non-invasive spectroscopy and imaging of normal breast function, hormonal stimulation, disease risk, and breast pathologies

• spectroscopy and imaging of soft tissues including wounds, injuries, and therapeutic interventions on skin, muscle, and internal organs

• spectroscopy imaging of tissue response to chemo-, radiation-, preventative, and hormonal therapies

• image-guided differential diagnosis, surgical planning, and medical (drug) therapy

• correlation of optical imaging biomarkers with gold standard methods, clinical endpoints, and validation in multi-center settings; novel hardware, probe, and imaging designs including improved signal processing, advances in sources and detectors, novel imaging geometries

• advances in forward/inverse methods and models, methods that account for tissue heterogeneity, and understanding limits of resolution and contrast; fundamental properties of photon density waves (PDW) and methods for control and measurement of PDW propagation

• multi-modality platforms, image co-registration and data visualization; functional origins of endogenous absorption contrast, including interpretation of dynamic signals, vascular reactivity, effects of dynamic perturbations, and cell-vascular coupling phenomena

• origins of tissue scattering contrast including relationship to cellular and extracellular matrix structure, dynamic signals, and in vivo histopathology

• connecting optical contrast elements across spatial scales, from microscopic to macroscopic, and specialized technologies for small animal model imaging

• exogenous absorption, scattering, and fluorescence contrast agents for enhanced cellular and molecular specificity

• enhancing speed, bandwidth, and information content of hardware methods and computational models

• development of specialized probes for spectroscopy and imaging in small tissue volumes and minimally-invasive, intra-operative settings

• cost-effectiveness, reducing barriers to access, and miniaturization

• development of new instrumentation, modeling and image reconstruction algorithms for time-resolved imaging with exogenous and endogenous fluorescence.

Conference Chairs: Bruce J. Tromberg, Beckman Laser Institute and Medical Clinic (USA); Arjun G. Yodh, Univ. of Pennsylvania (USA); Eva Marie Sevick-Muraca, The Univ. of Texas Health Science Ctr. at Houston (USA)

Conference Co-Chairs: Robert R. Alfano, The City College of New York (USA)

Program Committee: Samuel Achilefu, Washington Univ. School of Medicine in St. Louis (USA); David A. Boas, Massachusetts General Hospital (USA); Sergio Fantini, Tufts Univ. (USA); Marco Ferrari, Univ. degli Studi dell’Aquila (Italy); Amir H. Gandjbakhche, National Institutes of Health (USA); Jeremy C. Hebden, Univ. College London (United Kingdom); Andreas H. Hielscher, Columbia Univ. (USA); Jana M. Kainerstorfer, Tufts Univ. (USA); Anand T. N. Kumar, Athinoula A. Martinos Ctr. for Biomedical Imaging (USA); Frederic Leblond, Ecole Polytechnique de Montréal (Canada); Mark J. Niedre, Northeastern Univ. (USA); Brian W. Pogue, Dartmouth College (USA); Darren M. Roblyer, Boston Univ. (USA); Quing Zhu, Univ. of Connecticut (USA)

Medical imaging based on near infrared (NIR) trans-il-lumination is a powerful and cost-effective approach for characterizing thick tissues. Technological devel-opments using principles of Diffuse Optical Spectros-copy (DOS), Diffuse Optical Imaging (DOI), Diffuse Optical Tomography (DOT), and Diffuse Correlation Spectroscopy (DCS) have helped drive significant advances in quantitative, model-based NIR methods. Diffuse optical technologies account for the effects of multiple light scattering in tissue and have been applied to a broad variety of problems in biology and medicine spanning from cancer and wound healing to muscle function and brain imaging. Many of these methods are designed to provide functional diag-nostic information about tissue physiology in real or near-real time. Capabilities include characterization and localization of endogenous absorption and scat-tering contrast and the use of exogenous absorption, fluorescence, and scattering agents for enhancing cellular and molecular specificity.

The transformation of optical contrast elements into validated imaging biomarkers that are predictive of disease and clinical outcome is a topic of major interest and activity. Because of their sensitivity to hemoglobin absorption and tissue scattering, a particularly powerful and unique capability of diffuse optical methods is their ability to measure tissue oxygen utilization and blood flow. The combination of intrinsic and extrinsic contrast elements into multi-modality DOI platforms provides functional, dynamic images with capabilities that rival, and in some cases exceed, conventional radiologic imaging approaches. Similarly, the combination of diffuse optical methods with established anatomic imaging technologies such as MRI, ultrasound, and x-ray imaging is a powerful strategy that can significantly enhance information content. As a result, diffuse optical methods provide cost-effective solutions for

diagnostic imaging and therapeutic guidance as either “stand-alone” or integrated “multi-modality” platforms.



Microfluidics, BioMEMS, and Medical Microsystems XIII (BO208)

Conference Chairs: Bonnie L. Gray, Simon Fraser Univ. (Canada); Holger Becker, microfluidic ChipShop GmbH (Germany)

Program Committee: Brian W. Anthony, Massachusetts Institute of Technology (USA); Yolanda Fintschenko, LabSmith, Inc. (USA); Bruce K. Gale, The Univ. of Utah (USA); Albert K. Henning, Aquarian Microsystems (USA); Yu-Cheng Lin, National Cheng Kung Univ. (Taiwan); Yuehe Lin, Pacific Northwest National Lab. (USA); Ciara K. O’Sullivan, Univ. Rovira i Virgili (Spain); Ian Papautsky, Univ. of Cincinnati (USA); Bastian E. Rapp, Karlsruher Institut für Technologie (Germany); Thomas Stieglitz, Albert-Ludwigs-Univ. Freiburg (Germany); Sindy Kam-Yan Tang, Stanford Univ. (USA); Albert van den Berg, MESA+ Institute for Nanotechnology (Netherlands); Wanjun Wang, Louisiana State Univ. (USA); Bernhard H. Weigl, PATH (USA)

The purpose of this conference is to provide an international technical forum to showcase recent advances in microfluidics, BioMEMS, and medical microsystems. Microfluidic devices and systems have created a tremendous interest in many application fields, including life sciences, point of care (POC) diagnostics, and environmental applications. They offer many advantages over the existing macroscale systems, including compact size, disposability, high-er speed and parallelism of analyses, increased func-tionality and decreased sample/reagent volumes. In the life sciences, recent research efforts have focused on bio/chemical analyses, pharmaceutical high-throughput systems, and biomaterial surface modification. The interaction of microsystems with living cells or tissues opens a pathway to novel methods of medical diagnostics and therapeutics. Thus, the range of interests has expanded from the molecular scale over single cells to more complex biological systems, and finally, living organisms. Further, several conventional methods in medical engineering for diagnosis and therapy have also been shifting towards miniaturization and MEMS technologies, including minimally invasive surgery, in vivo and ex vivo monitoring, and smart implants. Last, but not least, environmental applications have focused on developing inexpensive sensors for in situ monitoring of contaminants in the environment for public safety or measuring a person’s exposure to environmental contamination.

For many of these applications, microfluidics and other MEMS technologies are essential, as they provide the functional basis of many research tools as well as commercial devices and applications. Thus, over the past several years, there has been a significant increase in the activities associated with understanding, development, and application of mi-cromechanical and microfluidic devices and systems for BioMEMS and medical microsystems.

Papers are solicited on the following major topics and other related subjects:

MICRO/NANO FLUIDIC COMPONENTS• fluid delivery, transport, and control• micro -valves, -pumps, -mixers, and -reactors• nanofluidic devices and systems• microdroplet generation and manipulations• micro-heating/cooling devices• emerging microfluidic approaches (inertial

microfluidics, electrofluidics, optofluidics)• CAD, modeling, and analysis.

MICROFABRICATION TECHNOLOGIES FOR MICROFLUIDICS AND BIOMEMS• polymer microfabrication methods• emerging fabrication technologies (e.g., paper

microfluidics)• fluidic modules and interconnects• fluidic packaging and assembly• microstructuring of organic materials• functional materials for microfluidics and

BioMEMS• surface texturing and modification.

APPLICATIONS OF MICROFLUIDICS, BIOMEMS, AND MEDICAL MICROSYSTEMS• point-of-care (POC) medical monitoring and

diagnostics• nano bio/medical sensors• optofluidics, on-chip waveguides and optical

detection• cell-based sensing devices and systems, flow

cytometry• implantable medical microsystems• sensors and systems for environmental

monitoring• sensors and systems for in vitro/in vivo

monitoring and diagnosis• microfluidic-based drug development and

analysis.

BEST STUDENT PAPER AWARDA cash prize sponsored by microfluidic ChipShop GmbH will be awarded to the best student paper.

Judging and RequirementsPresentations and manuscripts will be judged based on scientific merit, impact, and clarity. Can-didates for the award need to be the presenting author, a full-time student, must have conducted the majority of the research presented in the paper, and must submit their manuscript by the deadline (12 January 2015).

NominationsTo be considered, submit your abstract online, select “Yes” when asked if you are a full-time student, and select yourself as the speaker.


TISSUE OPTICS, LASER-TISSUE INTERACTION, & TISSUE ENGINEERING

Optical Interactions with Tissue and Cells XXVI (BO300)

Conference Chairs: E. Duco Jansen, Vanderbilt Univ. (USA); Robert J. Thomas, Air Force Research Lab. (USA)

Program Committee: Hope Thomas Beier, Air Force Research Lab. (USA); Randolph Glickman, The Univ. of Texas Health Science Ctr. at San Antonio (USA); Steven L. Jacques, Oregon Health & Science Univ. (USA); Bennett L. Ibey, Air Force Research Lab. (USA); Beop-Min Kim, Korea Univ. (Korea, Republic of); Jessica C. Ramella-Roman, The Catholic Univ. of America (USA); Marissa Nicole Rylander, Virginia Polytechnic Institute and State Univ. (USA); Alfred Vogel, Univ. zu Lübeck (Germany); Gerald J. Wilmink, Air Force Research Lab. (USA)

The basic mechanisms of laser tissue and cell interac-tions fall into three categories: photochemical, pho-tomechanical, and photothermal. These mechanisms form a fundamental basis for the field but are now expanded to include the cellular and bio-molecular response to irradiation from lasers and laser systems both in vitro and in vivo. Understanding the funda-mental mechanisms of interactions between light, tissue and cells is the basis for the development of future biomedical optic technologies that include both therapeutic and diagnostic applications.

This conference will focus on papers which examine the fundamental mechanisms of the light-tissue interaction, at both the tissue and cellular levels, and their role in the emerging optical technologies for biomedical applications. As a special focus, we invite researchers examining these fundamental mechanisms in the context of nanomedicine. The conference seeks papers regarding both theoretical and experimental approaches, including approaches for advanced numerical simulations. The aim of this conference is to provide a forum for those investigat-ing fundamental physics, biochemistry, and biology in order to seed future engineering approaches. The conference identifies optical technologies that will be useful in addressing problems of biomaterials, tissue engineering and tissue mechanics.

This year’s conference will include a special section on Terahertz and Ultrashort Electromagnetic Pulses (uSEP) for Biomedical Applications. This special session aims to highlight (uSEP) and THz source de-velopment, biological applications, and fundamental interactions with tissues, cells, and biomolecules. Scientific papers that push the state-of-the-art are solicited.

A preliminary list of session topics is listed below. Please include these terms in abstracts for the pur-pose of organizing sessions.• photothermal interactions• photochemical and photo-oxidative interactions• photomechanical effects• mechanisms of pulsed laser ablation• ultrafast pulsed laser interactions• fundamental mechanisms in nanomedicine• optical monitoring of tissue mechanics• optical properties of tissues• cellular micro-and nanosurgery• cellular biomolecular response• mechanistic studies of laser welding and

soldering of tissue• numerical approaches simulating laser-tissue

interactions and response.• nanosecond electric pulse bioeffects• THz technology, sensing, and biological effects.

JOINT SESSIONA special joint session with LASE conference LA115: Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XV is planned for 2015. The focus of the session will be biomedical applications of sub-nanosecond pulse lasers, with topics relating to interactions with cells and tissues.



Dynamics and Fluctuations in Biomedical Photonics XII (BO301)

Conference Chairs: Valery V. Tuchin, N.G. Chernyshevsky Saratov State Univ. (Russian Federation), Univ. of Oulu {Finland); Kirill V. Larin, Univ. of Houston (USA); Martin J. Leahy, National Univ. of Ireland, Galway (Ireland); Ruikang K. Wang, Univ. of Washington (USA)

Program Committee: Pierre O. Bagnaninchi, The Univ. of Edinburgh (United Kingdom); Wei R. Chen, Univ. of Central Oklahoma (USA); Joseph P. Culver, Washington Univ. School of Medicine in St. Louis (USA); Ekaterina I. Galanzha, Univ. of Arkansas for Medical Sciences (USA); Miya Ishihara, National Defense Medical College (Japan); Jingying Jiang, Tianjin Univ. (China); Sean J. Kirkpatrick, Michigan Technological Univ. (USA); Jürgen M. Lademann, Charité Universitätsmedizin Berlin (Germany); Hong Liu, The Univ. of Oklahoma (USA); Qingming Luo, Huazhong Univ. of Science and Technology (China); Igor V. Meglinski, Univ. of Otago (New Zealand); Brian S. Sorg, Univ. of Florida (USA); Vladislav Toronov, Ryerson Univ. (Canada); Lihong V. Wang, Washington Univ. in St. Louis (USA); Ying Yang, Keele Univ. (United Kingdom); Anna N. Yaroslavsky, Univ. of Massachusetts Lowell (USA); Vladimir P. Zharov, Univ. of Arkansas for Medical Sciences (USA); Dan Zhu, Huazhong Univ. of Science and Technology (China)

The conference will be devoted to applications of recent developments in dynamics and control, coher-ence and synchronicity in networks, and statistical physics to biomedical photonics with a particular emphasis on functional monitoring and imaging. The goal of the conference is to gather essentially five groups of leading researchers:• biophysicists• physicians• biologists and neuroscientists• mathematicians• optical and laser engineers

along with graduate and undergraduate students to facilitate future progress in the development of optical and laser technologies based on a dynamics approach to biomedical science and clinical applica-tions. This approach will be useful for diagnosis and therapy of diseases such as those of the heart and vasculature, cancer, psoriasis, mental illness, and many others that manifest as a breakdown of the living organism’s auto-regulation systems at the level of molecule, cell, organ, or organism as a whole. This methodology is also intended to promote a deeper understanding of the role of complex dynamics in biological development across all length scales from embryos to tissues, to organs and systemic functions. This conference contributes to the development of interdisciplinary fields of science and applications such as dynamics and structures of living systems, biomedical optics, and laser medicine, and we hope that it will continue to be helpful for scientists, phy-sicians, engineers and students.

Papers are solicited on photonics technologies, including diffusion, fluorescence and polarization spectroscopies, OCT, Doppler, speckle, photoacous-tics, and nanophotonics, applied for estimation, monitoring,imaging and/or controlling of:• dynamics of stochastic systems in biology and

medicine• circulation in the blood and lymph microvessels• brain and eye function• optogenetics• dynamics of heartbeat, breath, fibrillary tremor,

bowel, lungs, eyeball tremor, etc.• bio-vibrations, tremor and breath measuring

technologies and instruments• contractile activity of blood and lymph vessels,

flow measurement and imaging• microcirculation imaging• red blood cell and other bio-particle

sedimentation and aggregation processes• cell proliferation• cell drug and dye uptake• intracellular flows and contractile activity of cells• molecular agents, intelligent particles and

collective behavior• molecular motor driving• stochastic cluster dynamics of macromolecules• nonlinear diffusion of metabolic and exogenous

agents and nanoparticles in tissues• glucose sensing• fractal point processes and cell structure

analysis• fluctuations and chaos in living systems and

organisms• stochastic resonance and synchronization in

neural science and cardiology• adaptive coherent optical systems for medicine• engineered tissues and organs.


CALL FOR PAPERS

Photons Plus Ultrasound: Imaging and Sensing 2015 (BO302)

Conference Chairs: Alexander A. Oraevsky, TomoWave Laboratories, Inc. (USA); Lihong V. Wang, Washington Univ. in St. Louis (USA)

Program Committee: Mark A. Anastasio, Washington Univ. in St. Louis (USA); Paul C. Beard, Univ. College London (United Kingdom); A. Claude Boccara, Institut Langevin (France); Stanislav Y. Emelianov, The Univ. of Texas at Austin (USA); Rinat O. Esenaliev, The Univ. of Texas Medical Branch (USA); Martin Frenz, Univ. Bern (Switzerland); Pai-Chi Li, National Taiwan Univ. (Taiwan); Andreas Mandelis, Univ. of Toronto (Canada); Vasilis Ntziachristos, Helmholtz Zentrum München GmbH (Germany); Matthew O’Donnell, Univ. of Washington (USA); Günther Paltauf, Karl-Franzens-Univ. Graz (Austria); Wiendelt Steenbergen, Univ. Twente (Netherlands); William M. Whelan, Univ. of Prince Edward Island (Canada); Vladimir P. Zharov, Univ. of Arkansas for Medical Sciences (USA); Qifa Zhou, The Univ. of Southern California (USA); Quing Zhu, Univ. of Connecticut (USA)

This conference will be dedicated to imaging, sensing, monitoring and spectroscopy based on the combi-nation of light and sound by synergistically utilizing the high optical contrast and the high ultrasonic resolution. The images based on optical contrast are complementary to images based on ultrasonic con-trast. The hybrid technology such as optoacoustic/photoacoustic tomography can provide anatomical and functional imaging for comprehensive tissue characterization. It is also capable of providing high-resolution molecular imaging. The areas of inter-est include methods involving optically and thermally induced acoustic waves and acoustically modulated optical waves and a variety of photothermal and photoacoustic phenomena, covering basic research, instrumentation and applications. Biomedical appli-cations include cancer detection, localization, and differentiation, detection of atherosclerotic plaques, vascular imaging and angiography.

Topics that involve both sound and light include:• microscopy• endoscopy• computed tomography• scanning imaging• image reconstruction• signal processing• ultrasonic transducers• contrast agents• sensing• spectroscopy• microwave or RF excitation of ultrasonic waves• ultrasonic encoding of light• wavefront engineering• time-reversed ultrasonically encoded (TRUE)

optical focusing• quantitative imaging• functional imaging• molecular imaging• multimodality imaging• small animal imaging• clinical imaging• monitoring of therapy• other advances

BEST PAPER AWARD AND BEST POSTER AWARDSeno Medical Instruments of San Antonio, Texas, will sponsor two Awards at this Conference for the Best Paper and the Best Poster. Authors: to qualify for the two awards the proceedings man-uscripts (4 to 12 pages) must be submitted by no later than midnight, Friday, January 30, 2015.





Biophotonics and Immune Responses X (BO303)Conference Chairs: Wei R. Chen, Univ. of Central Oklahoma (USA)

Program Committee: Gianfranco L. Canti, Univ. degli Studi di Milano (Italy); Sandra O. Gollnick, Roswell Park Cancer Institute (USA); Yueqing Gu, China Pharmaceutical Univ. (China); Michael R. Hamblin, Wellman Ctr. for Photomedicine (USA); Tomas Hode, Immunophotonics, Inc. (USA); Yih-Chih Hsu, Chung Yuan Christian Univ. (Taiwan); Zheng Huang, Univ. of Colorado Denver (USA); Vyacheslav Kalchenko, Weizmann Institute of Science (Israel); Mladen Korbelik, The BC Cancer Agency Research Ctr. (Canada); Mark F. Naylor, Dermatology Associates of San Antonio (USA); Karl-Goran Tranberg, CLS Ltd. (Sweden); Valery V. Tuchin, N.G. Chernyshevsky Saratov State Univ. (Russian Federation); Xunbin Wei, Shanghai Jiao Tong Univ. (China); Da Xing, South China Normal Univ. (China); Zhihong Zhang, Huazhong Univ. of Science and Technology (China); Vladimir P. Zharov, Univ. of Arkansas for Medical Sciences (USA)

Immunological responses are crucial in the treat-ment of diseases. Phototherapy (photothermal, photochemical, and photomechanical), often used in conjunction with immunotherapy, has shown promise in stimulating and enhancing host immune systems. Recently, many researchers have started human clinical studies using photo-immunotherapy. This conference will provide a forum for discussion and interaction among people from academia, indus-try, and health professions who are working in this area. It will serve as a bridge between technology development and clinical applications, in the field of phototherapy-related immune activities.

This conference will focus on induction, enhance-ment, mechanisms, and detection of immune re-sponses induced by phototherapy and combination modalities. It will specifically address the issue of searching for an effective immunological modality for different diseases, ranging from autoimmune diseases to cancer, using optical methods. It will also address the issue of detecting immune activities, using modern technologies such as molecular and cellular imaging, as well as other imaging modalities. It will include research using different combination modalities, novel approaches for stimulations of sys-temic responses, innovative methods in monitoring and guiding photo-immunotherapy, and immuno-logical responses related to nanotechnology-based phototherapeutics and diagnosis.

Preliminary session topics include:• opto-immune therapies• novel technologies in monitoring immune activities• novel combination therapy in cancer treatment• new approaches in inducing immune responses• local and systemic effects of low intensity laser

irradiation• local and systemic effects of high intensity laser

irradiation• sensing and sensors for immune activities• molecular imaging for immune responses• in vitro cellular and biomolecular responses• in vivo cellular and biomolecular responses• immunophotonics in diagnostics and therapeutics• photodynamic therapy and immune responses• photoimmunotherapy in clinical applications• light-induced vaccination.

Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue VII (BO304)Conference Chairs: Jean-Pierre Bouchard, INO (Canada); David W. Allen, National Institute of Standards and Technology (USA)

Program Committee: Anant Agrawal, U.S. Food and Drug Administration (USA); Gerald T. Fraser, National Institute of Standards and Technology (USA); Rongguang Liang, College of Optical Sciences, The Univ. of Arizona (USA); Ramesh Raghavachari, U.S. Food and Drug Administration (USA); Heidrun Wabnitz, Physikalisch-Technische Bundesanstalt (Germany)

If biomedical optical technologies are to cross the chasm from bench to bedside, they must be sub-jected to the rigors of validation at many levels. Phantoms, in addition to their current use in research, will play a crucial role as independent verification artifact to insure data consistency across multiple instruments and even vendors. Phantoms used in the highly regulated phase of clinical trials and field use will have to be fabricated to the same quality standards as the biomedical optical devices they are serving. In addition, their physical properties will have to be accurately known and traceable to the international system of units.

This conference provides a forum for scientists and engineers from academia, industry, and government to discuss the issues affecting the design and re-quired performance characteristics of phantoms for optical devices in medicine. Papers are encouraged that describe the application of phantoms for perfor-mance comparison and validation of instruments. In addition, phantom design and validation procedures, quality control, testing and uncertainty analysis, shape and boundary issues, dynamic methods, and disease conditions being simulated are welcome. Submissions dealing with simulation of benign and disease-free tissue condition as well as the simulation of various disease conditions such as cancer precur-sors are also encouraged.


CALL FOR PAPERS

Energy-Based Treatment of Tissue and Assessment VIII (BO305)

Conference Chairs: Thomas P. Ryan, ArthroCare (USA)

Program Committee: James E. Coad M.D., West Virginia Univ. (USA); Chris J. Diederich, Univ. of California, San Francisco (USA); Paul J. Hoopes, Dartmouth Medical School (USA); Paul R. Stauffer, Duke Univ. (USA); Sharon L. Thomsen, Pathology Consultant to Engineers and Physicists (USA); John A. Pearce, The Univ. of Texas at Austin (USA)

This is a comprehensive session encompassing tissue treatment, monitoring, assessment, and guidance, and marks the eleventh occurrence of this two-day conference. The conference will gather work covering a range of energy-based delivery systems including thermal as well as non-thermal techniques (laser, RF, microwave, conductive, cryo, ultrasound, and others). These delivery systems are for the treatment of tissue, in both malignant and nonmalignant states, and in some cases, to enhance or replace a surgical procedure. Low-level energy systems that facilitate healing or ablate tissue with non-thermal techniques, such as plasma medicine, are welcome. All anatom-ical sites are open for discussion. The conference will bring together engineers, physicists, and other scientists as device designers and modelers, as well as clinicians, including surgeons, radiologists and pathologists who are practitioners of the art and sci-ence of delivering and evaluating energy-based treat-ments. Companies with Medical Devices, Imaging, or Image Guidance Systems currently on the market or in development are also welcome to present model-ing, performance and clinical effects, including new sites and applications. Coverage of anatomical sites such as skin, liver, kidney, lung, heart, blood vessels, prostate, uterus, breast, eye, brain, hard and soft connective tissues including bone, cartilage, spine, and other sites are invited to participate. Robotics assisted and Image Guided devices and techniques will also be covered.

The conference will have sessions that include:

THERAPEUTIC ENERGY DELIVERY• microwaves• lasers• radiofrequency (RF)• cryotherapy/conductive sources• therapeutic ultrasound• nanoparticle-based heating• energy delivery + adjuvant therapy

LOW-LEVEL ENERGY DELIVERY (NON-THERMAL) FOR HEALING, ABLATION, AND TISSUE/CELLULAR MODIFICATION• plasma• electrotherapy, bone and soft-tissue healing• electroporation/mechanical ultrasound• drug delivery control; clot/stroke treatment

NANOTECHNOLOGY/NANOMEDICINE• mechanism/modeling• imaging/tissue effects• localization approaches• heating and therapeutic technology

MODELING AND HEAT TRANSFER IN TISSUE• 2D, 3D, and 4D models of tissue effects and

treatment progress.

TISSUE EFFECTS• tissue ablation/removal• tissue shrinkage and reshaping• surgical vessel sealing• coagulation necrosis• hemostasis• modification of tumor microenvironment• cellular activation• reversible changes (i.e. perfusion, oxygenation)

ASSESSMENT OF DAMAGE OR TISSUE CHANGES DURING OR FOLLOWING TREATMENT• cell death processes and thermal damage

assessment• optical/acoustic/electromagnetic methods• MR, CT, PET; elastography.

ASSESSMENT OF TEMPERATURE DURING TREATMENT• CT, MR, ultrasound, microwave

CLINICAL APPLICATIONS• applications of devices on the market• new technologies, applications, or sites• animal and clinical studies/pathology

GUIDANCE OF THERAPY• diagnostic ultrasound, MR, CT navigation

systems/robotic assistance.



Optical Elastography and Tissue Biomechanics (BO306)

Conference Chairs: Kirill V. Larin, Univ. of Houston (USA); David D. Sampson, The Univ. of Western Australia (Australia)

Program Committee: Jeffrey C. Bamber, Institute of Cancer Research (United Kingdom); A. Claude Boccara, Institut Langevin (France); Stephen A. Boppart M.D., Univ. of Illinois at Urbana-Champaign (USA); Brett E. Bouma, Wellman Ctr. for Photomedicine (USA); Zhongping Chen, Beckman Laser Institute and Medical Clinic (USA); Donald D. Duncan, Portland State Univ. (USA); Kishan Dholakia, Univ. of St. Andrews (United Kingdom); Daniel S. Elson, Imperial College London (United Kingdom); Mathias Fink, Institut Langevin (France); Brendan F. Kennedy, The Univ. of Western Australia (Australia); Sean J. Kirkpatrick, Michigan Technological Univ. (USA); Seemantini K. Nadkarni, Harvard Medical School (USA); Kentaro Nakamura, Tokyo Institute of Technology (Japan); Amy L. Oldenburg, The Univ. of North Carolina at Chapel Hill (USA); Francesco S. Pavone, European Lab. for Non-linear Spectroscopy (Italy); Andrew Pelling, Univ. of Ottawa (Canada); Gabriel Popescu, Univ. of Illinois at Urbana-Champaign (USA); Giuliano Scarcelli, Harvard Medical School (USA); Gijs van Soest, Erasmus MC (Netherlands); Victor X. D. Yang, Ryerson Univ. (Canada); Seok Hyun A. Yun, Wellman Ctr. for Photomedicine (USA); Ruikang K. Wang, Univ. of Washington (USA); Qifa Zhou, The Univ. of Southern California (USA)

This conference is devoted to developments and applications of biomedical optics, biophotonics and optical microscopy in the assessment of the biome-chanics of cells and tissues. Optical elastography is the use of optics to characterize tissues and cells based on their elastic and viscoelastic mechanical properties. In deploying the high-resolution capa-bility of optics, this rapidly emerging field builds on and complements the related fields of ultrasound and magnetic-resonance elastography, as well as existing methods for biomechanics, such as atomic force microscopy and microrheology.

Accurate determination of tissue biomechanical properties could help with clinical diagnosis and in-terpretation of a wide variety of diseases. Mechanical forces also play an important role in the behavior and development of biological systems and disease at all spatial scales, from cells and their constituents, to tissues and organs. Such forces have a profound influence on the health, structural integrity, and normal function of cells and organs.

The multidisciplinarity of optical elastography and tissue and cell biomechanics will see this conference bring together technology and applications experts in bioengineering, biophysics, cell biology, clinical sciences, medical imaging, optics and photonics, and tissue engineering. In so doing, we hope to contribute to the development of interdisciplinary bonds in supporting scientists, engineers, biologists and physicians interested in the broad field of tissue biomechanics.

Papers are solicited on biomedical optics, biopho-tonics and biomechanical methods and technologies applied or related to estimation, monitoring, and functional assessment of the mechanical properties of normal and pathological biomaterials at all spatial scales, from cells and their constituents to tissues and organs. Relevant topics include (but are not limited to):• optical elastography methods in general• optical coherence tomography/elastography• speckle and particle tracking, and holography• signal processing methods for optical

elastography• quantitative methods, including combining

modeling and measurement• novel loading schemes, such as focused

ultrasound, photothermal and magnetomotive• methods for measuring viscoelastic properties in

particular• photoacoustics directed towards biomechanics• Brillouin scattering for biomechanics• optical tweezers applied to cellular and

subcellular mechanical properties• scanning probe and other nanoscale methods

for biomechanics• dynamic methods for characterizing tissue

vibration, such as in the ear and vocal chords• optical elastography applications in general• in vivo elastography• elastography applied to characterization of ex

vivo and in vivo tissue pathology• intraoperative elastography applications (such

as in breast cancer, lung cancer and others)• elastography in cardiology• biomechanics of the eye• ophthalmic applications of optical elastography• hard tissue biomechanics in bones and dental

applications• biomechanics in animal models• biomechanics in tissue engineering• biomechanics in developmental biology• microrheology measurements using optical

techniques• cell mechanics methods (related to, e.g., motility,

adhesion, and mechanotransduction).


This conference of related interest is part of LASE 2015 co-located at Photonics West, www.spie.org/lasecall

CALL FOR PAPERS

Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XV (LA115)

Conference Chairs: Alexander Heisterkamp, Leibniz Univ. Hannover (Germany); Peter R. Herman, Univ. of Toronto (Canada); Michel Meunier, Ecole Polytechnique de Montréal (Canada); Stefan Nolte, Friedrich-Schiller-Univ. Jena (Germany)

Program Committee: Craig B. Arnold, Princeton Univ. (USA); James E. Carey III, SiOnyx Inc. (USA); Xun Gu, ABB Corporate Research (Switzerland); Denise M. Krol, Univ. of California, Davis (USA); Eric Mazur, Harvard Univ. (USA); Michael M. Mielke, Raydiance, Inc. (USA); Eric P. Mottay, Amplitude Systèmes (France); Christopher B. Schaffer, Cornell Univ. (USA); Alexander Szameit, Friedrich-Schiller-Univ. Jena (Germany); Alfred Vogel, Univ. zu Lübeck (Germany); Wataru Watanabe, Ritsumeikan Univ. (Japan); Sascha Weiler, TRUMPF Inc. (USA)

Recent advances in ultrafast laser technology have resulted in widespread availability of robust, prac-tical laser sources. As a result, useful applications for these sources have emerged in many different fields, from micromachining and THz-imaging to nonlinear microscopy and semiconductor testing to laser surgery and communications. Now in its fifteenth year, this conference is the premier venue for discussing the development of new ultrafast laser sources, the manipulation and characterization of ultrashort pulses as well as their use in biomedical, scientific and industrial applications. We anticipate a larger conference than ever that will bring together a multi-disciplinary group consisting of university researchers from diverse fields, as well as scientists and engineers from industry. A program that includes invited and tutorial presentations will provide the context for contributed talks and posters, and for stimulating discussions.

We encourage submission of papers on all aspects of applications of ultrafast lasers and on ultrafast laser technology development. In addition, all graduate and undergraduate students are encouraged to enter their submissions in the Student Competition for best presentation (see below). General topics include, but are not limited to, the following areas: • emerging ultrafast laser technologies and novel

systems • ultrafast laser source engineering for industrial

and biomedical use • characterization and measurement of ultrashort

pulses• ultrashort pulse delivery and beam manipulation • ultrashort pulse propagation and nonlinear

effects in materials • interaction of ultrashort pulses with materials • surface and bulk micromachining using ultrafast

lasers • interactions and modification of biological

tissues

• tissue and surgical applications of ultrashort pulse lasers

• optical manipulation of biological systems with ultrashort pulses

• micro and nano manipulation of cells and organelles, optical transfection

• ultrafast lasers in plasmonics, interaction with nanoparticles

• novel medical applications of ultrafast lasers • applications and generation of x-ray ultrashort

pulses.

CONFERENCE HIGHLIGHTSIn addition to the exciting technical program that has been the hallmark of previous years, we plan several highlights this year: • Joint sessions with LA110, addressing the field

of laser processing by ultrashort lasers • Joint session on Sunday with BiOS BO300

covering recent advances in imaging and manipulation of cells and tissues using ultrashort laser pulses

• Session hosting the best student competition, awarding the best student paper.

JOINT SESSIONS WITH LA110 AND LA115Ultrafast Laser MicromachiningThis session will address important emerging technologies at the picosecond, femtosecond and attosecond time scale, for a broad audience of researchers in the fields of ultra-fast lasers and laser processing, together with experts at the forefront of alternative micro- and nanofab-rication technologies. The topics will cover, but will not be limited to, fundamentals of ultra-fast laser-matter interaction and novel machining techniques.

JOINT SESSIONS WITH BIOS BO300 AND LA115Ultrafast Laser Interaction with Tissues and CellsThese sessions will deal with the emerging optical technologies based on ultrafast laser interaction with tissues and cells for biomedical applications. These sessions will occur on Sunday, in good overlap with sessions of other BiOS conferences. The topics will cover but will not be limited to, fundamentals and applications of ultrafast la-ser-imaging, manipulation and modification of cells or tissues, like optical transfection, nerve generation, interaction with nanoparticles and multiphoton imaging.

COSPONSORS:

(LA115) (continued next page)



STUDENT COMPETITIONThanks to generous corporate sponsorship, we are happy to announce that a student competition will be held again this year. Due to the great success in previous years, the competition will be a gen-eral best student award, taking posters and talks into account. The winner will be announced and awarded a $1000 cash prize to the best student paper, with the runner-up students receiving a cash prize as well.

Judging and RequirementsPapers submitted by graduate and undergradu-ate students are eligible. In order to ensure a fair evaluation the conference chairs and the program committee will judge the students within a special session held during the conference. Here, the students have to present a brief summary of their original talk or poster presented at our conference with a time limit of 5 minutes. Presentations will be judged based on content, scientific impact, orga-nization, quality of presentation, and presenter’s mastery of the subject. Candidates for the award need to be the presenting author, a full-time student, must have conducted the majority of the research presented in the paper, and must submit their manuscript to the conference proceedings.

NominationsTo be considered, submit your abstract online, select “Yes” when asked if you are a full-time stu-dent, and select yourself as the speaker. Note that prior first prize holders may participate, but will not be eligible for a cash prize. Please be aware, that the submission of a manuscript to the SPIE Proceedings is mandatory to be able to take part.

Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XV (LA115) (continued)


BIOMEDICAL SPECTROSCOPY, MICROSCOPY, AND IMAGING

Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XIII (BO400)

Conference Chairs: Daniel L. Farkas, Univ. of Southern California (USA), SMI {United States); Dan V. Nicolau, McGill Univ. (Canada); Robert C. Leif, Newport Instruments (USA)

Conference Co-Chairs: James F. Leary, Purdue Univ. (USA); Attila Tarnok, Univ. Leipzig (Germany); Rebecca R. Richards-Kortum, Rice Univ. (USA)

Program Committee: Vadim Backman, Northwestern Univ. (USA); Christopher H. Contag, Stanford Univ. School of Medicine (USA); Paul M. W. French, Imperial College London (United Kingdom); Yuval Garini, Bar-Ilan Univ. (Israel); DaeGab Gweon, KAIST (Korea, Republic of); Charles P. Lin, Wellman Ctr. for Photomedicine (USA); Sacha Loiseau, Mauna Kea Technologies (France); Ramesh Raghavachari, U.S. Food and Drug Administration (USA); Sebastian Wachsmann-Hogiu, Univ. of California, Davis (USA); Warren S. Warren, Duke Univ. (USA)

This interdisciplinary conference addresses the knowledge continuum from molecular structure and fundamental mechanisms to biological, energy pro-duction, and medical applications, focusing on new approaches to imaging, manipulation, and analysis of biomolecules, cells, and tissues, both in vitro and in vivo. The conference will report on the latest de-velopments in functional and multispectral imaging, optogenetics, analysis, algorithms, quantification, separation, sorting, and standards for cells (cytomics) and tissues (histomics). The principal aim is to further improve the interdisciplinary dialog between those who design and implement critical technologies and the primary users who study important problems that drive developments, in order to advance translational research.

Reports of original research contributions are solic-ited on the following topics:

FUNCTIONAL IMAGING OF BIOMOLECULES, LIVE CELLS AND TISSUES• light microscopy of living cells and tissues (2D,

3D, 4D)• spectral imaging of multiple cellular and tissue

components• new and automated methods for monitoring

biological structure and physiology• microscopic imaging of electric potentials and

events• mesoscopic (microscopic resolution in vivo)

tissue imaging• multimode and multimodality tissue imaging in

vivo

BIOPHOTONIC TECHNIQUES FOR REGENERATIVE MEDICINE• stem cell characterization in vitro• stem cell imaging and tracking in vivo• in vivo studies of immunologic events• imaging methods in organ transplantation• functional monitoring of tissue engineering

constructs• imaging of tissue oxygenation and

vascularization

OPTICAL MANIPULATION OF CELLS AND TISSUES• cell micromanipulation using optical trapping• cellular effects of localized energy deposition

into micro- and nano-absorbers• cells and biomolecules in micro- and nano-

confined spaces• scanning probe microscopy of cells and surface-

immobilized biomolecules

SPECTRAL IMAGING AND MULTIPARAMETER MEASUREMENTS (MICROSCOPIC AND MACROSCOPIC)• spectral pathology• digital imaging for quantitative pathology and

clinical applications {RCL clinical and pathology are related

• small animal imaging• bioenergy applications• tools and approaches for combining optical and

other measurements• tools and approaches for combining several

optical imaging methods• advanced registration and visualization

ADVANCED QUANTITATIVE CELL (CYTOMICS) AND TISSUE (HISTOMICS) ANALYSIS• fluorescence and phosphorescence lifetime

imaging• instrumentation and technology• probes, including new dyes• high-throughput cytometry• in situ diagnostic applications• technologies for multispectral and

multiparameter imaging, including acquisition, segmentation and analysis methods

• new components for cytometry instrumentation, including ultraminiature and nanosystems

• clinical and research applications of cytometry, with emphasis on new and unusual approaches

• new methods for cell separation including high-speed, optical and magnetic-paramagnetic sorting

• rare event detection• circulating stem, fetal, cancer, and other rare

cells• mutant selection• medical problems in need of advanced

quantitative cell or tissue analysis

MICROARRAYS FOR BIOMOLECULES, CELLS, AND TISSSUES• printing technologies• readout methods, including image analysis and

quantification• applications of microarrays in diagnostics and

drug discovery.

(BO400) (continued next page)



BIOINFORMATICS, IMAGE AND DATA PROCESSING, QUANTIFICATION, STANDARDS, AND DISPLAY METHODS• cell-based high-throughput and high-content

screening clustering algorithms• analytical quantification, including new methods

for multiparameter cell and tissue analysis and data manipulation

• automated 3D image processing, including tracking of tissue section surfaces, image segmentation, and fluorimetry/densitometry

• software standards and regulatory requirements for spectroscopy, flow cytometry, and imaging

• image formats, databasing, and retrieval• advanced image registration and display,

including co-display of multimodality image sets

MONITORING OF PILOT AND INDUSTRIAL CELL AND TISSUE GROWTH AND PRODUCTION FOR:• biomedical products applications• tissue engineering• energy applications

JOINT SESSIONBiomedical Imaging and Cell Manipula-tion using a Digital Micromirror or other Micro-Electro-Mechanical Systems (MEMS) Array DeviceThis special joint session is in conjunction with OPTO conference OE120: Emerging Digital Mi-cromirror Device Based Systems and Applications VII. The utilization of the DMD and other optical MEMS arrays to manipulate light has numerous medical applications ranging from cancer detec-tion to operating room aids to the manipulation of individual cells.Papers are solicited that address the uses of a DMD and other Optical MEMS arrays with:• 3D medical visualization• confocal microscopes• hyperspectral imaging• image-guided intervention• optoelectronic tweezers• organs on a chip• oxygenation measurements• phototherapy• selectable wavelength light sources• structured light• tissue illumination.

Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XIII (BO400) (continued)


Call for PaPers

Multiphoton Microscopy in the Biomedical Sciences XV (BO401)

Conference Chairs: Ammasi Periasamy, Univ. of Virginia (USA); Peter T. C. So, Massachusetts Institute of Technology (USA); Karsten König, Univ. des Saarlandes (Germany)

Program Committee: Wolfgang Becker, Becker & Hickl GmbH (Germany); Alberto Diaspro, Istituto Italiano di Tecnologia (Italy); Chen-Yuan Dong, National Taiwan Univ. (Taiwan); Kevin W. Eliceiri, Univ. of Wisconsin-Madison (USA); Scott Fraser, California Institute of Technology (USA); Paul M. W. French, Imperial College London (United Kingdom); Hans C. Gerritsen, Utrecht Univ. (Netherlands); Enrico Gratton, Univ. of California, Irvine (USA); Min Gu, Swinburne Univ. of Technology (Australia); Stefan W. Hell, Max-Planck-Institut für Biophysikalische Chemie (Germany); Paul J. Campagnola, Univ. of Wisconsin-Madison (USA); Satoshi Kawata, Osaka Univ. (Japan); Fu-Jen Kao, National Yang-Ming Univ. (Taiwan); Arnd K. Krueger, Spectra-Physics®, a Newport Corp. Brand (USA); Joseph R. Lakowicz, Univ. of Maryland School of Medicine (USA); Steve M. McDonald, Coherent, Inc. (USA); Angelika C. Rueck, Univ. Ulm (Germany); Junle Qu, Shenzhen Univ. (China); Steven S. Vogel, National Institutes of Health (USA); Paul W. Wiseman, McGill Univ. (Canada); X. Sunney Xie, Harvard Univ. (USA); Bernhard Zimmermann, Carl Zeiss Jena GmbH (Germany); Warren R. Zipfel, Cornell Univ. (USA); Chris Xu, Cornell Univ. (USA)

Multiphoton microscopy has been established as the 3D imaging method of choice for studying biomedical specimens, from single cells to whole animals, with sub-micron resolution. Two decades have passed since the realization of two-photon microscopy, and the ever-expanding scope of applications and continuing instrumental innovations require a forum where new ideas can be exchanged and presented. Our conference in the SPIE BiOS 2015 meeting con-tinues to address this need.

Submitted proceedings manuscripts may also be submitted to the Journal of Biomedical Optics (please visit http: //spie.org/x85029.xml for details).

Topics include:• multiphoton (one- or two- or three- or more

photons) microscopy theory and system development

• multiphoton (MP) in wide-field and laser scanning confocal microscopy

• infrared lasers for MP systems (femtosecond vs. picosecond vs. CW)

• tissue engineering, endoscopy and animal imaging using 2photon microscopy

• endogenous molecular imaging and its applications

• fluorescence resonance energy transfer imaging (FRET)

• fluorescence lifetime imaging (frequency and time domain) (FLIM) and its applications

• fluorescence correlation spectroscopy and image cross correlation spectroscopy (FCS, ICCS)

• harmonic generation microscopy (SHG, THG) and its applications

• Raman/SRS/CARS/CRS spectroscopy and microscopy and their applications

• fluorescence recovery after photobleaching (FRAP), uncaging and photoactivation

• various biological applications including developmental, neurobiology, plant biology, calcium and pH imaging

• photodynamic therapy (PDT) and clinical imaging

• photo-thermal, -chemical and -mechanical effects of IR radiation

• light sheet microscopy• laser safety and other related applications.

Student PoSter SeSSion ComPetitionGraduate students and postdoctoral fellows are welcome to participate in the poster session competition of the conference on Multiphoton Microscopy in the Biomedical Sciences. There is a cash award for the winner(s). Participants should follow the rules and regulations of SPIE for submission of their abstract and manuscript. Participants should also register their names for the competition with the conference Chair during first day of the conference. Submitted proceeding manuscripts are allowed for resubmission to the Journal of Biomedical Optics (please visit http: //spie.org/x85029.xml for details).

JenLab Young inveStigator awardWe encourage graduate students, postdocs, and scientists or junior faculty who are not more than 32 years old to apply for the JenLab Young Investigator Award. To be eligible for this $2000 cash award, participants must be both the primary author and presenter of an accepted abstract and the proceedings paper must be submitted by the due date, prior to the meeting, for review by the selection committee. Submitted proceedings manuscripts may be resubmitted to the Journal of Biomedical Optics (please visit http: //spie.org/x85029.xml for details). To self-nominate, please enter “Jen Lab Young Investigator Award” as a keyword in your abstract. Prize donated by JenLab GmbH, Germany.

SPONSOR:



Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXII (BO402)

Conference Chairs: Thomas G. Brown, Univ. of Rochester (USA); Carol J. Cogswell, Univ. of Colorado at Boulder (USA); Tony Wilson, Univ. of Oxford (United Kingdom)

Program Committee: Martin Booth, Univ. of Oxford (United Kingdom); G. J. Brakenhoff, Univ. van Amsterdam (Netherlands); José-Angel Conchello, Harvard Univ. (USA); Charles A. DiMarzio, Northeastern Univ. (USA); Raimund J. Ober, The Univ. of Texas at Dallas (USA); Chrysanthe Preza, Univ. of Memphis (USA); Monika Ritsch-Marte, Innsbruck Medical Univ. (Austria)

For over 20 years, this conference has been a venue to present exciting advances in multidimensional mi-croscopy, including confocal- and coherence-based imaging systems, and microscopes based on flu-orescence, phase imaging, and nonlinear optics. While many of the instruments are oriented toward biomedical imaging, the papers usually include applications such as materials science, industrial inspection, and nanoscale metrology. Many micro-scopes are now fully integrated systems, including computer hardware and software. It is hoped that the broad range of relevant topics being presented at this conference will serve to encourage interaction among instrumentation engineers, computer image analysts, and researchers in the various fields of application.

We consider papers that cover overall system design, as well as more specialized areas: optical image for-mation, image recording, deconvolution and image restoration in two, three, or more dimensions, image classification, and digital methods of producing and displaying the resulting reconstruction. We especially encourage submission of articles on novel optical and digital techniques for imaging or detecting object features approaching the nanometer-scale range.

In addition, we encourage submission of articles on the growing research area of full-field quantitative phase imaging, including hardware, models, multiv-iew tomography, algorithms and applications.

Papers are invited in the following and related areas:• instrumentation and methods for microscopy in

2, 3, or more dimensions • innovations in optical modes for microscopy

(such as interference, fluorescence, or polarizing) in reflection or transmission

• full-field quantitative phase imaging, including quantitative DIC and holographic imaging techniques

• innovations aimed toward nanostructure detection and imaging, including STED, PALM, STORM, etc.

• superresolution• confocal microscopy• new modes of multiphoton fluorescence

excitation microscopy• probe microscopy (atomic force microscopy,

near-field scanning optical microscopy)• time-resolved image acquisition systems• image processing and analysis• image reconstruction in 2, 3, or more dimensions• deconvolution and image estimation in 2, 3, or

more dimensions• computational models• computational optical sensing and imaging

(COSI) techniques for microscopy• point spread function engineering for enhanced

image information content• wavefront manipulation techniques for

correcting aberrations, extending depth of field, etc.

• spectral and hyperspectral imaging• specimens and procedures for testing and

evaluating new instruments and algorithms• spatio-temporal reconstruction of living cells

and tissues• applications in materials science• 3D image visualization techniques, including

volume rendering, animation, stereoscopic and holographic displays

• holographic microscopy• single-plane illumination microscopy (SPIM)• microtomography• light sheet microscopy• total internal reflection fluorescence (TIRF)

microscopy.


CALL FOR PAPERS

Single Molecule Spectroscopy and Superresolution Imaging VIII (BO403)

Conference Chairs: Jörg Enderlein, Georg-August-Univ. Göttingen (Germany); Ingo Gregor, Georg-August-Univ. Göttingen (Germany); Zygmunt Karol Gryczynski, Univ. of North Texas Health Science Ctr. at Fort Worth (USA), Texas Christian Univ. at Fort Worth {United States); Rainer Erdmann, PicoQuant GmbH Berlin (Germany); Felix Koberling, PicoQuant GmbH (Germany)

Program Committee: Sohail Ahmed, A*STAR Institute of Medical Biology (Singapore); Michael Börsch, Friedrich-Schiller-Univ. Jena (Germany); Christian Eggeling, Univ. of Oxford (United Kingdom); Paul M. W. French, Imperial College London (United Kingdom); Ewa M. Goldys, Macquarie Univ. (Australia); Johan Hofkens, Katholieke Univ. Leuven (Belgium); Zhen-Li Huang, Huazhong Univ. of Science and Technology (China); Thomas R. Huser, Univ. Bielefeld (Germany); Maria Teresa Neves-Petersen, International Iberian Nanotechnology Lab. (Portugal); Markus Sauer, Univ. Bielefeld (Germany); Shimon Weiss, Univ. of California, Los Angeles (USA); Andong Xia, Institute of Chemistry (China)

The focus of this conference are all fields of optical single molecule spectroscopy and imaging, ranging from fundamental physics, technical and method-ological questions, towards applications in chemical, biological and biomedical research as well as medical diagnostics. It provides a state-of-the-art interdis-ciplinary forum for information exchange on new technological developments, advanced applications, and fundamental questions of the field.

Ultrasensitive spectroscopic techniques have become an important tool in fundamental biological and biomedical research, allowing study of the function and interaction of individual biomolecules. Improving and extending the existing arsenal of techniques for studying specific biophysical and biochemical questions on a single molecule level is of paramount interest for the life-science community.

This conference puts special emphasis on time re-solved methods of fluorescence spectroscopy which allow for investigating not only structural properties but also the function of molecular processes, down to the single molecule level. Therefore, we encour-age to submit work related also to Fluorescence Lifetime Imaging (FLIM), Advanced single-molecule techniques such as Fluorescence Correlation Spec-troscopy (FCS), Fluorescence Coincidence Analysis or single-molecule burst analysis are also favorite subjects of this conference. In particular Förster resonance energy transfer (FRET) analysis frequently benefits from theses time-resolved methods and this conference will be an excellent platform to discuss their application at the molecular level.

A topic of particular interest has become the employ-ment of the single-molecule nature of fluorescence excitation and emission to achieve sub-diffraction superresolution in fluorescence microscopy. It has opened previously unknown opportunities to image live cells in the optical far field with unprecedented optical resolution. This resulted in new microscopy modalities such as Stimulated Emission Depletion (STED) microscopy, single molecule localization microscopy (PALM, STORM, dSTORM, GSD-IM),

stochastic optical fluctuation microscopy (SOFI), or structured illumination microscopy (SIM) techniques. The conference provides an interdisciplinary platform for these new and exciting developments in fluores-cence imaging.

The need for ultrasensitive and specific biomedical diagnostics requires development of optical and photonic detection/sensing technologies capable of reaching the single molecule level. The technical challenges to rapidly and specifically detect chem-ical and biological agents at minimal concentration levels are enormous and largely yet to be realized. All spectroscopic techniques (optical spectroscopy, fluorescence spectroscopy, elastic scattering, Raman scattering, IR spectroscopy, terahertz spectroscopy) as well as the chemical and biological sciences them-selves including genetically

encoded fluorescent markers, are potentially critical components for a multidisciplinary approach to ultrasensitive sensing and diagnostics.

Invited and contributed papers are solicited concern-ing, but not limited to, the following areas:• techniques and methods of single molecule (SM)

detection• techniques and methods of SM spectroscopy

(such as FCS, FLCS, FLIM, FRET)• techniques of single molecule manipulation• superresolution fluorescence imaging (STED,

PALM, (d)STORM, GSD-IM, SOFI, SIM and related techniques)

• multi-modal SM detection such as combining AFM with confocal microscopy

• correlative microscopy such as combining optical and electron microscopy

• fundamental aspects of SM spectroscopy• biophysical applications of SM spectroscopy and

imaging• medical applications of SM spectroscopy and

imaging SM imaging and tracking in cells and tissues

• ultrasensitive biomedical diagnostics• high-throughput screening applications• chemical and biochemical sensing photonic

materials for ultrasensitive optical detection• plasmonics and metal-enhanced fluorescence

for ultrasensitive optical detection• microfluidics and capillary devices

PICOQUANT YOUNG INVESTIGATOR AWARDYoung scientists (age 32 or below and not yet full faculty members) are encouraged to participate in this best paper competition, which offers a 1000 USD cash award. Participants must be both the primary author and presenter of an accepted abstract to be eligible. Please note in your abstract submission to this conference



Optical Diagnostics and Sensing XV: Toward Point-of-Care Diagnostics (BO404)Conference Chairs: Gerard L. Coté, Texas A&M Univ. (USA)

Program Committee: Brent D. Cameron, The Univ. of Toledo (USA); Werner Gellermann, The Univ. of Utah (USA); Jürgen M. Lademann, Charité Universitätsmedizin Berlin (Germany); Kristen C. Maitland, Texas A&M Univ. (USA); Michael J. McShane, Texas A&M Univ. (USA); Kenith E. Meissner, Texas A&M Univ. (USA); Aydogan Ozcan, Univ. of California, Los Angeles (USA); Babak Shadgan M.D., The Univ. of British Columbia (Canada); Kexin Xu, Tianjin Univ. (China); Shaoqun Zeng, Britton Chance Ctr. for Biomedical Photonics (China)

The focus of this conference will be on invasive and noninvasive optical methods for the diagnostics and sensing of all types of biological fluids: blood, lymph, saliva, mucus, gastric juice, urine, aqueous humor, semen, etc. both in vitro and in vivo.

The optical properties of these fluids and the tech-niques to monitor the fluids will be discussed includ-ing: elastic, quasi-elastic, and inelastic (Raman) light scattering, Doppler flowmetry, spectrophotometry, polarimetry, diffraction, holography, speckle, fluo-rescence, imaging, and related spectroscopic and microscopic techniques. Studies of biological fluid components on cellular and macromolecular levels, as well as nondestructive measurements of gas and analyte content, will be presented. Theoretical and model studies, as well as clinical applications of the developed optical methods and instrumentation, will be outlined. Diagnostics and sensing systems for point-of-care and global health applications are particularly encouraged.

Suggested topics include, but are not limited to, the following areas:• point-of-care diagnostic and sensing systems• global health diagnostics and sensing systems• in-home diagnostics and monitoring systems• glucose monitoring approaches• analyte monitoring in vivo and in vitro• biological fluid spectroscopy and imaging• local flow velocity measurement• blood microcirculation and tissue perfusion

monitoring• blood cell and macromolecular interaction and

aggregation sensing• blood cell deformation, orientation, diffusion,

and sedimentation imaging• fluid viscosity measurement• effects of physical and chemical factors on fluid

composition, rheological, and other properties• disease diagnostic potential of optical

techniques.

Biomedical Applications of Light Scattering X (BO405)Conference Chairs: Adam Wax, Duke Univ. (USA); Vadim Backman, Northwestern Univ. (USA);

Program Committee: Irving J. Bigio, Boston Univ. (USA); Stephen A. Boppart M.D., Univ. of Illinois at Urbana-Champaign (USA); Dirk J. Faber, Academisch Medisch Ctr. (Netherlands); Steven L. Jacques, Oregon Health & Science Univ. (USA); Ofer Levi, Univ. of Toronto (Canada); Lev T. Perelman, Harvard Univ. (USA); Brian W. Pogue, Thayer School of Engineering at Dartmouth (USA); Bruce J. Tromberg, Beckman Laser Institute and Medical Clinic (USA)

Light scattering techniques are under development as biomedical diagnostics for their ability to accu-rately and precisely determine structures within bi-ological samples. Clinical applications have included detecting pre-cancerous and cancerous tissue states both in vivo and with ex vivo biopsy samples, charac-terizing the mechanical properties of cells and tissues for identifying disease and for assessing the presence and concentration of biochemicals for diagnostic purposes. The development of these clinical modal-ities has relied upon implementing light scattering instruments, creating models of light scattering by normal and diseased tissues and devising new analy-sis methods. In addition, light scattering has also been employed in pre-clinical cell biology studies which seek to detect structural changes of sub-cellular components such as mitochondria and cell nuclei. Improved understanding of the relationship between light scattering signals and underlying morphological changes has relied upon these pre-clinical studies in developing new clinical modalities.

The increasing use of light scattering techniques for biomedical applications has led to a significant presence at Photonics West in recent years, with invited and contributed talks appearing across sev-eral conferences. This conference consolidates this presence with a focused conference on biomedical applications of light scattering.

Papers are solicited on (but not restricted to) the following areas:• Clinical applications of light scattering methods,

including:• dynamic light scattering• speckle contrast imaging• elastic scattering spectroscopy• polarized light scattering spectroscopy• low coherence light scattering• diffuse reflectance spectroscopy• enhanced backscattering spectroscopy.• Applications of light scattering for identifying

biochemicals• Light scattering methods for assessing structural

properties of cells and tissues for clinical diagnostics, such as cancer detection

• Methods for determination of biological structure based on analysis of optical properties

• Pre-clinical cell biology investigations using light scattering, including:

• light scattering microscopy• goniometry.

(BO405) (continued next page)


CALL FOR PAPERS

Optical Methods in Developmental Biology III (BO406)

Conference Chairs: Andrew M. Rollins, Case Western Reserve Univ. (USA); Cecilia W. Lo, Univ. of Pittsburgh (USA); Scott E. Fraser, California Institute of Technology (USA)

Program Committee: Michael A. Choma M.D., Yale School of Medicine (USA); Anjul M. Davis, Thorlabs Inc. (USA); Mary E. Dickinson, Baylor College of Medicine (USA); Robert G. Gourdie, Virginia Polytechnic Institute and State Univ. (USA); Michael W. Jenkins, Case Western Reserve Univ. (USA); Bradley B. Keller, Univ. of Louisville (USA); Kirill V. Larin, Univ. of Houston (USA); Kersti K. Linask, Univ. of South Florida (USA); Charles D. Little, The Univ. of Kansas Medical Ctr. (USA); Lars Thrane, Technical Univ. of Denmark (Denmark); Ruikang K. Wang, Univ. of Washington (USA); Michiko Watanabe, Case Western Reserve Univ. (USA); Talât Mesud Yelbuz, Medizinische Hochschule Hannover (Germany)

Developmental biology is approaching a deeper understanding of how dynamic events shape the embryo, requiring more quantitative and higher resolution tools and approaches. Studying the tiny, fragile embryo, with its rapid morphogenesis, is a sig-nificant challenge, especially at early stages when the body plan is being established, organ systems first develop, and trajectories toward congenital defects are initiated. Many mechanisms underlying normal and abnormal development are not well understood and technologies are needed to analyze structure/function relationships in the living embryo.

In this postgenomic era, the development of new genetic and optogenetic tools is providing unprec-edented opportunities to experimentally manipulate and observe the living embryo. There is also growing interest in developing fetal interventions based on basic biological mechanisms underlying congenital disease. Imaging is changing the face of develop-mental biology and the clinical, in utero management of congenital diseases. Because of the spatial and temporal resolution they enable, optical methods underlie many emerging imaging and quantitative tools that are playing an increasingly prominent role in these areas.

SPONSORS:

This conference will bring together technology and application experts and will emphasize novel tech-nologies and quantitative methods based on optical tools for developmental biology and fetal medicine. Papers are welcome that address opportunities and challenges including:• real-time, minimally invasive live embryo imaging• anatomical, functional and molecular imaging• optical imaging of embryonic/fetal cardiovascular

deve lopment , anatomy, and phys io logy• comprehensive volumetric imaging of whole

embryos• time-lapse in vivo imaging of cell, tissue, and

organ motion during morphogenesis• spatial-temporal molecular expression in the

living embryo• optogenetic approaches in live embryo imaging• computational image analysis• cilia-driven fluid flow and ciliary motion analysis• fetoscopy/embryoscopy• laser surgery• novel optical imaging methods.

Biomedical Applications of Light Scattering X (BO405) (continued)

• Light scattering instrumentation for biomedical diagnostics, including:

• confocal microscopy• spectroscopic optical coherence tomography.• Novel light scattering techniques for clinical

applications• Quantitative phase imaging for assessing

scattering features• Theoretical modeling of light scattering for

clinical applications, including:

• numerical modeling• analytical treatments.• Experimental and modeling studies of

microscopic origins of light scattering in tissue.



Adaptive Optics and Wavefront Control for Biological Systems (BO407)

Conference Chairs: Thomas G. Bifano, Boston Univ. (USA); Joel Kubby, Univ. of California, Santa Cruz (USA); Sylvain Gigan, Univ. Pierre et Marie Curie (France)

Program Committee: Jacopo Bertolotti, Univ. of Exeter (United Kingdom); Martin J. Booth, Univ. of Oxford (United Kingdom); Wonshik Choi, Korea Univ. (Korea, Republic of); Meng Cui, Howard Hughes Medical Institute (USA); John M. Girkin, Durham Univ. (United Kingdom); Na Ji, Howard Hughes Medical Institute (USA); Benjamin Judkewitz, California Institute of Technology (USA); Ori Katz, Univ. Pierre et Marie Curie (France); Peter A. Kner, The Univ. of Georgia (USA); Pablo Loza-Alvarez, ICFO - Institut de Ciències Fotòniques (Spain); Allard P. Mosk, Univ. Twente (Netherlands); Rafael Piestun, Univ. of Colorado at Boulder (USA); Laura Waller, Univ. of California, Berkeley (USA); Monika Ritsch-Marte, Medizinische Univ. Innsbruck (Austria)

Wavefront engineering has greatly expanded the capability of optical microscopy and measurements in biological systems. Recent breakthroughs in measuring and controlling optical wavefront have led to many important applications, including deep tissue microscopy with improved imaging quality and depth, optical tweezers with sophisticated shape and momentum distribution, and three-dimensionally patterned optogenetic excitation. This conference will bring together leading experts in a variety of research fields that employ innovative wavefront control technologies for biomedical applications.

Technical papers concerning the following aspects of adaptive optics are appropriate for submission and consideration:• adaptive optics for microscopy and optical

coherence tomography• guide-star probes for wavefront measurement

and light guiding in biological tissues• focusing light through scattering tissues

(optimization, transmission matrix)• channel de-mixing for endoscopy• wavefront shaping for photoacoustic and

acousto-optical imaging• applications of time-reversal in biological

imaging, optical phase conjugation• shaped beams for light sheet and structured

illumination microscopy• coherent optical adaptive techniques• computed optical imaging techniques• wavefront shaping devices (deformable mirrors,

spatial light modulators).


CALL FOR PAPERS

Quantitative Phase Imaging (BO408)

Conference Chairs: Gabriel Popescu, Univ. of Illinois at Urbana-Champaign (USA); YongKeun Park, KAIST (Korea, Republic of)

Program Committee: Peter T. C. So, Massachusetts Institute of Technology (USA); Pietro Ferraro, Istituto Nazionale di Ottica (Italy); Myung K. Kim, Univ. of South Florida (USA); Gert von Bally, Univ. Münster (Germany); Audrey K. Ellerbee, Stanford Univ. (USA); Theo Lasser, Ecole Polytechnique Fédérale de Lausanne (Switzerland); Changhuei Yang, California Institute of Technology (USA); George Barbastathis, Massachusetts Institute of Technology (USA); Laura Waller, Univ. of California, Berkeley (USA); Colin James Richard Sheppard, Istituto Italiano di Tecnologia (Italy); Jerome Mertz, Boston Univ. (USA); Aydogan Ozcan, Univ. of California, Los Angeles (USA); Demetri Psaltis, Ecole Polytechnique Fédérale de Lausanne (Switzerland)

Quantitative phase imaging (QPI) refers to quanti-fying at each point in the field of view the optical pathlength shift introduced by a specimen. This measurement allows for label-free and quantitative assessment of cells and tissues. The quantitative phase images of specimens are related to their refrac-tive index distribution, an intrinsic optical property, which plays an important role in the study of patho-physiology of many diseases. This rapidly emerging field enables the investigation of cells and tissues in terms of morphology and dynamics with nanoscale sensitivity over temporal scales from milliseconds to days. Accurate determination of intrinsic properties, optical, chemical, and mechanical, is likely to help with both basic understanding of cell function and interpretation of pathological states. Employing the principles of interferometry and holography, QPI provides unique capabilities not only for imaging, but for propagation of optical fields as well. As a result, QPI can be used to improve image quality of instruments affected by aberrations, i.e., QPI provides opportunities for non-iterative adaptive optics. With reliable phase information, an imaging instrument becomes also a powerful device for measuring light scattering. Thus, quantitative phase imaging has recently bridged the gap between the imaging and scattering disciplines. This approach is called Fourier transform light scattering, as it represents the spatial analog to Fourier transform spectroscopy. Using QPI, one can easily measure angular scattering from a single cell, which offers opportunities for label-free cell sorting.

This conference is a forum for disseminating the development of methodologies of QPI and their applications to studying specimens. The multidisci-plinary nature of QPI will see this conference bring together technology and application experts in elec-trical and bioengineering, physics and biophysics, cell biology, analytical chemistry, clinical sciences, medical imaging, optics and photonics, and tissue engineering. We will contribute to the development of interdisciplinary bonds in supporting scientists, engineers, biologists and physicians interested in the broad field of label-free quantitative phase imaging.

Papers are solicited on biomedical optics, biopho-tonics methodologies and applications in the broad area of QPI. Technology development activities are expected to advance the current state of the art in, for example: spatial phase sensitivity, temporal phase sensitivity, acquisition rate, resolution, tomographic reconstruction, spectroscopic content, throughput, phase reconstruction, phase unwrapping, image pro-cessing algorithms, user friendliness, etc. Application activities are expected to target specific biological questions, including: quantifying, monitoring, and functionally assessing the normal and pathological states in live cells and tissues from subcellular to organ scales.

Relevant topics include, but are not limited to:

QPI METHODOLOGIES• methods for QPI in general• digital holography for QPI applications• off-axis interferometric methods• phase shifting interferometric methods• common path interferometry for QPI• QPI using the transport of intensity equation• low-coherence interferometry for QPI

applications• phase-sensitive optical coherence tomography

and microscopy• multimodal techniques: QPI plus other methods

(e.g., fluorescence)• using QPI to retrieve scattering information from

cells and tissues• Fourier-transform light scattering• use QPI for non-iterative adaptive optics• numerical field propagation and time-reversal

applications• optical tweezers and QPI• probes for QPI, such as nanoparticles• single cell mechanics, motility, and adhesion• particle tracking using QPI.

ALGORITHMS AND IMAGING PROCESSING IN QPI• coherence effects in QPI• image processing methods for QPI• field and phase retrieval algorithms.

QPI OF CELL & TISSUE STUDIES• quantitative phase imaging of cells• quantitative phase imaging of tissues• cell growth assessment using QPI• using QPI for measuring biomechanics of cells

and tissue• quantitative phase imaging in neuroscience• quantitative phase imaging in biophysics• rheology measurements using QPI techniques.

CLINICAL APPLICATIONS OF QPI• quantitative phase imaging in tissue pathology• quantitative phase imaging in hematology.

New


NANO/BIOPHOTONICS

Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XI (BO500)

Conference Chairs: Alexander N. Cartwright, Univ. at Buffalo (USA); Dan V. Nicolau, McGill Univ. (Canada)

Program Committee: Vamsy P. Chodavarapu, McGill Univ. (Canada); Piotr A. Grodzinski, National Cancer Institute (USA); Sung Jin Kim, Univ. of Miami (USA); Brian D. MacCraith, Dublin City Univ. (Ireland); Paulo C. Morais, Univ. de Brasília (Brazil); Paras N. Prasad, Univ. at Buffalo (USA); Sharon M. Weiss, Vanderbilt Univ. (USA)

Novel applications and/or solutions to technological problems involving i) the use of nanostructures, nanoparticles, metamaterials and nanostructured materials for biological applications; ii) photonic studies of nanoscale interactions in biology and medicine; and iii) the use of biological materials/templates for the development of nanostructured nanophotonic imaging and sensing devices are sig-nificant foci of both industrial and academic research. These applications and solutions are inherently inter-disciplinary by nature and thus require a seamless transfer of knowledge between physics, chemistry, biology, medicine and engineering.

Recent integrative research efforts have included, for example, (a) nanotechnology (fabrication and appli-cation) as a tool in developing new, and improving existing, optical imaging techniques for real-time sub-wavelength imaging of cellular processes, (b) developing the next generation of nano-biosensors for improving biological / chemical sensing applica-tions, (c) using nanoparticles / nanostructures for optical engineering of methodologies for targeting and treatment of disease, (d) applying computer and information technologies in the development of new models and data analysis for understanding cellular mechanisms, (e) developing new photonic devices and systems that are hybrids of traditional polymeric and semiconductor materials with biolog-ical materials; and (f) very large scale and/or very sensitive detection down to single molecule level for drug discovery and diagnostics applications, such as nanoarrays.

The objective of this conference is to bring together scientists and researchers interested in the latest advances in the advancement of materials and methods that combine nanophotonics with biology. More specifically, this conference is to discuss the development of processing, characterization, and simulation of bioinspired and bioderived nanopho-tonic structures, metamaterials for sub-wavelength imaging, nanoscale interactions in biological systems, functionalized nanoparticles for biological applica-tions and the use of nanostructures / nanoparticles for high throughput analysis (nanoarrays).

The conference will focus on three streams of con-tributions:• nanoparticle use in imaging and sensing• nanostructures used for nanoscale / sub-

wavelength imaging• nanospectroscopy and nano-scale sensing

biomedical applications.

Papers from industry, government, academia, and other research organizations are solicited on the following and related topics:

FUNDAMENTALS (MATERIALS AND TOOLS)• studies of cellular and membrane biophysics

using nanophotonics (nanoparticles and nano-optics)

• characterization of nanoscale interactions in biological systems, e.g, near-field microscopy, scanning force microscopy

• development of sub-wavelength imaging (e.g., hyperlenses from metamaterials)

• nanocomposites of inorganic/organic hybrids for biophotonics

• biological templates for fabrication of nanophotonic devices

• bio-inspired and bio-derived nanstructured materials

• localized fluorescence spectroscopy using nanostructures and nanoparticles

• modeling and simulations of bio/nanophotonics• manipulation of biomolecules and cells at the

nano-level.

TECHNOLOGY (DEVICES)• nanoscale device design and processing for

biological applications• biological sensors based on nanophotonic

structures (e.g. photonic bandgap materials, porous silicon, metamaterials)

• multifunctional nanoparticles (targeting, imaging, and treatment)

• hybrid bionanodevices, e.g. molecular motors and nanofluidics.

APPLICATIONS• optical imaging using nanophotonics principles

(nanostructures, nanoparticles, etc.)• in-vitro and in-vivo applications of

nanophotonics (functionalized nanoparticles, surfaces, etc.)

• biomedical instrumentation development (nanosensors or nanoscale imagers).


CALL FOR PAPERS

Colloidal Nanoparticles for Biomedical Applications X (BO501)

Conference Chairs: Wolfgang J. Parak, Philipps-Univ. Marburg (Germany); Marek Osinski, The Univ. of New Mexico (USA); Xing-Jie Liang, National Center for Nanoscience and Technology, China (China)

Program Committee: Antigoni Alexandrou, Ecole Polytechnique (France); Ramon Alvares-Puebla, Catalan Center for Chemical Technology (Spain); Jesus M. de la Fuente, Univ. de Zaragoza (Spain); James B. Delehanty III, U.S. Naval Research Lab. (USA); Niko Hildebrandt, Institut d’Électronique Fondamentale (France); Jennifer A. Hollingsworth, Los Alamos National Lab. (USA); Thomas M. Jovin M.D., Max-Planck-Institut für Biophysikalische Chemie (Germany); Antonios G. Kanaras, Univ. of Southampton (United Kingdom); Hedi Mattoussi, The Florida State Univ. (USA); Igor Medintz, U.S. Naval Research Lab. (USA); Paul Mulvaney, The Univ. of Melbourne (Australia); Jay L. Nadeau, McGill Univ. (Canada); Subramanian Tamil Selvan, A*STAR Institute of Materials Research and Engineering (Singapore); Konstantin V. Sokolov, The Univ. of Texas M.D. Anderson Cancer Ctr. (USA); Claudia Tortiglione, Istituto di Cibernetica Eduardo Caianiello (Italy); Tania Q. Vu, Oregon Health & Science Univ. (USA); Horst Weller, Univ. Hamburg (Germany); Kenji I. Yamamoto M.D., National Ctr. for Global Health and Medicine (Japan)

Ongoing rapid progress in the synthesis of a variety of biofunctionalized colloidal nanoparticles with fascinating electronic, magnetic, and optical proper-ties not associated with bulk materials symbolizes a fundamental breakthrough in physics and chemistry of condensed matter, which significantly extends our knowledge about the nature of materials and our abilities to manipulate their properties. Inorganic nanostructures that interface with biological systems are attracting an increasingly widespread interest in biology and medicine. Quantum dot intravascular probes can be used in a remarkable number of bio-medical applications, such as highly specific markers for cellular microscopy, flow cytometry, DNA and protein chips, immunoassays for diagnostics, his-tology, cancer detection, in situ hybridization, PCR DNA detection, biochemical and cell-based drug screening, single molecule studies, and correlation spectroscopy. There are abundant opportunities for improved or completely novel probes and seemingly endless new applications. Also plasmonic and mag-netic nanoparticles can be used for a large number of biomedical applications.

This conference will consider biomedical applications of colloidal nano- and micro-particles, as well as recent advances in new materials and methods of synthesis, coating, and bioconjugation. Its objective is to provide a widely interdisciplinary forum for prac-ticing clinicians, biomedical scientists, development engineers, physicists, and chemists specializing in different fields to benefit from each other’s expert knowledge and to create trend-setting interdisci-plinary links that will accelerate progress in this field.

Previously unpublished experimental and theoretical papers are solicited on the following and related topics:

• synthesis of colloidal nanoparticles such as II-VI, I-VII, III-V, and group-IV semiconductor quantum dots; ternary compounds; core-shell nanoparticles; nano-onions; nanoshells; plasmonic nanoparticles; metal nanoparticles; magnetic nanoparticles; shape and size control; assembly of nanoparticles to bigger (micro) particles

• synthesis of colloidal microparticles such as layer-by-layer assembled capsules

• bioconjugation and biolabeling; bioconjugate chemistry; dendron ligands; thiol and oligonucleotide coatings; phospholipid micelles; biotin/avidin; sticky polymers; targeting peptides; target specificity

• measurement techniques; microscopy (AFM, SFM, STM, TEM, HRTEM, SNOM); XRD; spectroscopy (FTIR, EELS, ICP, DFS); spectroscopy of single quantum dots; multiphoton spectroscopy; frequency upconversion; magnetic sensing and imaging; plasmon spectroscopy; dynamic light scattering

• physics and characterization of colloidal nanoparticles; electronic structure, band alignment; dielectric screening; optical, electronic, and magnetic properties; excitons and biexcitons; quantum efficiency; intraband transitions; spin dynamics; blinking mechanisms, surface-enhanced Raman spectroscopy; plasmons

• theoretical and experimental studies of interactions with surrounding ambient, including dynamics and electronic structures

• numerical modeling; multiscale modeling; density functional modeling; molecular dynamics; Brownian dynamics; quantum Monte Carlo simulations

• biomolecular sensing; FRET; molecular interactions

• biocompatibility; development of non-toxic nanoparticles; intracellular behavior; long-term effects

• biological applications of colloidal nanoparticles; in vitro and in vivo imaging; biology at molecular level; receptor-ligand interactions; protein folding/unfolding; DNA conjugation, sequencing, and assembly; cell motility; gene expression mutation, etc.

• medical applications of colloidal nanoparticles; immuno-fluorescent assays; applications in neuroscience; drug delivery and screening; cancer diagnostics and therapy; screening; cancer diagnostics and therapy; biomechanics; etc.

OCEAN OPTICS YOUNG INVESTIGATOR AWARDThe award will be given for the best contributed paper presented by a leading author who is either a graduate student or has graduated within less than five years of the paper submission date. The award consists of a $1,000 cash prize to the Young Investigator and $2,000 Ocean Optics equipment credit to the laboratory where the work was performed. To be eligible, manuscripts of self-nominating authors must be received by the due date.


NANO/BIOPHOTONICS

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications (BO502)

Conference Chairs: Samuel Achilefu, Washington Univ. School of Medicine in St. Louis (USA); Ramesh Raghavachari, U.S. Food and Drug Administration (USA)

Program Committee: Bohumil Bednar, Merck & Co., Inc. (USA); Mikhail Y. Berezin, Washington Univ. School of Medicine in St. Louis (USA); Richard B. Dorshow, MediBeacon, LLC (USA); Paul M. W. French, Imperial College London (United Kingdom); Yueqing Gu, China Pharmaceutical Univ. (China); Hisataka Kobayashi, National Institutes of Health (USA); Ashok Kumar Mishra, Indian Institute of Technology Madras (India); D. Michael Olive, LI-COR Biosciences (USA); Gabor Patonay, Georgia State Univ. (USA); Attila Tarnok, Univ. Leipzig (Germany); Yasuteru Urano, The Univ. of Tokyo (Japan)

Chemical and genetic sensors, reporters, and molec-ular probes are the cardinal elements in molecular imaging and analyses of normal and pathophysio-logical processes at the cellular and molecular levels. Diverse molecular designs with unique optical signa-tures have been developed and are currently used to sense the presence and activity of molecular targets that characterize specific biological processes. These have been used to probe human diseases, explore the mechanisms of pathogenesis, monitor drug efficacy, discriminate healthy from diseased tissues, and assess therapeutic outcomes. These applications deploy molecular probes over a range of scales from microscopy and subcelluar resolution to optical tomography of entire organisms. Development and use of these probes typically involve multidisciplinary teams that have assembled to address specific bio-logical questions.

The objective of this conference is to provide a forum to present and collate significant and exciting studies involving chemically or biologically developed optical molecular probes that have been used in biomedical research. Papers appropriate for this solicitation include, but not limited to studies performed with dyes, bioluminescent enzymes, photoproteins such as GFP, activatable probes, receptor-, tissue-, or func-tion-specific probes, nonspecific contrast effectors, nanoparticles, quantum dots, and multimodal molec-ular probes, monitoring molecular and physiological processes in cell and living organisms, clinical use of imaging agents, and applications of biomarkers and sensors in medicine and biology. This conference will target state-of-the-art studies where these probes have been used, in vitro or in vivo, and encompasses a wide variety of applications. To accommodate the multidisciplinary nature of the conference, papers are requested from a variety of subject areas, including the following topics:

DESIGN, SYNTHESIS, DEVELOPMENT, OR ANALYSES OF NEAR-INFRARED AND OTHER FLUORESCENT DYES• novel dyes (fluorescent, absorption, and

environment-sensitive dyes)• novel luminescent probes• absorption-, fluorescent-, and light scattering-

based agents.

DESIGN, SYNTHESIS, DEVELOPMENT, AND ANALYSES OF NANOPARTICLES• caged complexes or chelated optical markers• quantum dots, micro- and nanoparticles.

DEVELOPMENT OF BIOLUMINESCENCE AND FLUORESCENT PROTEINS, INTRINSIC PROBES, AND MOLECULAR REPORTERS• function-specific chemical and biological

sensors• molecular beacons.

MARKERS FOR MEMBRANE POTENTIAL, ELECTROLYTES, AND PH REGULATIONS• structure-dependent spectroscopy• intracellular and extracellular pH measurements• functional analysis of biological processes in

cells and animals.

IN VITRO AND IN VIVO APPLICATIONS OF CONTRAST AGENTS AND MOLECULAR PROBES• genomics and proteomics, including gene

expression biological assays, including immunoassays, cell internalization, receptor binding, LRET, FRET and FISH studies

• physiologic function monitoring, including molecular and cellular events, pH, electrolytes, metabolites, minerals, and membrane potential

• in vivo organ function monitoring• molecular, cellular, and tissue imaging• site-specific delivery mechanisms and

endoscopy methods• multicolor and multimodality imaging systems

and upconversion markers• real-time monitoring of disease progression or

regression• tandem diagnostic and therapeutic interventions• molecular ruler design and application• monitoring treatment response• contrast agents for imaging applications.

TIME-RESOLVED TISSUE SPECTROSCOPY FOR MEDICAL DIAGNOSIS AND IMAGING• fluorescence lifetime spectroscopy and imaging• fluorescence lifetime of endogenous and

exogenous fluorescent materials and molecules• time-resolved fluorescence methods based on

endogenous and exogenous molecules.

BIOMARKERS• new disease biomarkers• imaging disease biomarkers• methods for identify and amplify signals for

imaging biomarkers.

PATHWAY TO CLINICAL TRANSLATION OF IMAGING PROBES AND NANOMATERIALS• human studies using imaging agents• challenges of human translational studies with

contrast agents and optical probes• regulatory issues related to human studies by

optical methods.

JOINT SESSIONNonbleaching and Ultrasmall Fluorescent TagsThis special joint session is in conjunction with OPTO conference Advances in Photonics of Quan-tum Computing, Memory, and Communication VII.


CALL FOR PAPERS

Plasmonics in Biology and Medicine XII (BO503)

Conference Chairs: Tuan Vo-Dinh, Fitzpatrick Institute For Photonics, Duke Univ. (USA); Joseph R. Lakowicz, Univ. of Maryland School of Medicine (USA)

Program Committee: A. Claude Boccara, Ecole Supérieure de Physique et de Chimie Industrielles (France); Michael T. Canva, Lab. Charles Fabry (France); Volker Deckert, Institut für Photonische Technologien e.V. (Germany); Bruce S. Dunn, Univ. of California, Los Angeles (USA); Christopher D. Geddes, Univ. of Maryland, Baltimore (USA); Zygmunt Karol Gryczynski, Univ. of North Texas Health Science Ctr. at Fort Worth (USA); Naomi J. Halas, Rice Univ. (USA); Ho-Pui A. Ho, The Chinese Univ. of Hong Kong (Hong Kong, China); Jiri Homola, Institute of Photonics and Electronics of the ASCR, v.v.i. (Czech Republic); Laura Maria Lechuga, Ctr. d’Investigacions en Nanociència i Nanotecnologia (Spain); Boris Mizaikoff, Univ. Ulm (Germany); Shuming Nie, Emory Univ. (USA); Krishanu Ray, Univ. of Maryland School of Medicine (USA); Wei-Chuan Shih, Univ. of Houston (USA); Weihong Tan, Univ. of Florida (USA); Andrew Taton, Univ. of Minnesota, Twin Cities (USA); Richard P. Van Duyne, Northwestern Univ. (USA); Jeffrey I. Zink, Univ. of California, Los Angeles (USA)

The goal of this conference is to provide an inter-disciplinary forum for state-of-the-art methods and instrumentation related the new research area of plasmonics and related nanosystems and their ap-plications in biology and medicine. Plasmonics refers to the investigation, development and applications of enhanced electromagnetic properties of metallic nanostructures. The term plasmonics is derived from plasmons, which are the quanta associated with longitudinal waves propagating in matter through the collective motion of large numbers of electrons. Incident light irradiating these surfaces excites conduction electrons in the metal, and induces excitation of surface plasmons leading to enormous electromagnetic enhancement.

A forum that integrates interdisciplinary research and development is critically needed for scientists, engineers, and clinical providers to present the most recent advances in instrumentation and methods as well as biomedical applications in the new field of plasmonics in biology and medicine.

The focus is on the following topics:• properties of metallic nanostructures• nanophotonics systems• plasmonics-based sensors• surface plasmon resonance (SPR) sensing

systems• surface-enhanced Raman scattering (SERS) and

biomedical applications• surface-enhanced luminescence (SEL) and

biomedical applications• bioprobes and nanoprobes• nanosensors• nanoarchitectures and nanooptics• fabrications of nanostructured substrates• spectroscopies related to plasmonics• single-molecule spectroscopy• single-molecule manipulation• single-cell analysis• cellomics using nanoparticle technology• metallonomics detection using plasmonics• nanosystems for drug delivery• metal nanoparticle contrast agents for medical

diagnostics• photonic atoms• metal-enhanced fluorescence MEF• surface plasmon-coupled emission SPCE.




NANO/BIOPHOTONICS

Bioinspired, Biointegrated, Bioengineered Photonic Devices III (BO504)

Conference Chairs: Luke P. Lee, Univ. of California, Berkeley (USA); John A. Rogers, Univ. of Illinois at Urbana-Champaign (USA); Seok Hyun Andy Yun, Harvard Univ. (USA)

Program Committee: David Erickson, Cornell Univ. (USA); Malte C. Gather, Univ. of St. Andrews (United Kingdom); Viktoria Greanya, Defense Threat Reduction Agency (USA); Hongrui Jiang, Univ. of Wisconsin-Madison (USA)

This conference will cover a variety of biomedical photonic devices using principles, materials, and structures that are biologically inspired or bioengi-neered, implantable, biodegradable, wearable, and that often mimic nature at scales from nano to macro levels. Such devices are primarily used for sensing, di-agnostics, and therapeutic applications in medicine, solving the limitations of conventional optical devices and conventional approaches. Forward-looking, innovative ideas driven by intellectual curiosity are also welcome. With emphasis placed on biomimetic technologies and biomaterials at the device level, this conference invites papers describing novel concepts, proofs of concept, fabrications, in vitro tests, and in vivo studies, as well as applications in the field.

Specific topics include the following:• optical devices and components made of

biocompatible materials• implantable photonic and optoelectronic devices• bioimplants consisting of light-interacting cells

and molecules• bioimplants for imaging and controlling cells and

tissues• biodegradable, bioresorbable optical devices• biointegrated optical sensors• wearable, implantable optofluidic devices• biological lasers and biomolecular light sources• biointegrated light delivery into deep tissues• novel biomaterials for photonic devices• bioinspired photonic structures for applications• biomimetic macro, micro, or nano optical

devices.




CALL FOR PAPERS

Be part of the solution–present your work in translational research and be recognized by your peers

Symposium Chair:

Bruce TrombergBeckman Laser InstituteUniv. of California, Irvine (USA)

The global community recognizes the need for ad-vances in technology to meet challenges in health care, particularly health issues that impact broad populations and incur large societal and individual costs.

The new SPIE BiOS Translational Research virtual symposium will highlight papers from BiOS that showcase the latest photonics technologies, tools, and techniques with high potential to impact healthcare.

Papers are solicited on the following topics:• Photonic Therapeutics and Diagnostics• Clinical Technologies and Systems• Tissue Optics, Laser-Tissue Interaction, and

Tissue Engineering• Biomedical Spectroscopy, Microscopy, and

Imaging• Nano/Biophotonics

To be considered for inclusion in the Translational Research virtual symposium, submit your abstract online, and enter “TRANSLATIONAL” when prompt-ed. Accepted papers will be cross-listed in the SPIE Translational Research Virtual Program, and you will be eligible to win an SPIE Translational Research Best Paper Award. Award finalists will be contacted and asked to provide a 1-2 page summary explaining how the research is “translational.”

Virtual Symposium on Applications of 3D Printing

The potential of 3D printing and manufacturing for applications such as supplying critical parts in the automotive and aerospace industries, fabricating replacement parts in remote environments, and, increasingly, producing personalized medical im-plants, is a rapidly evolving phenomenon in the field of manufacturing.

The SPIE Applications of 3D Printing Virtual Sympo-sium will highlight papers that address these exciting developments:• additive manufacturing• selective laser melting, laser sintering, laser

photopolymerization

• novel materials, protean materials, and laser interactions

• software that increases efficiencies and speed• in-situ sensors or probes to verify and quantify

additive manufacturing processes in real time• conformal photonics/electronics.

If your research fits the criteria of contributing in an innovative way to this multidimensional/multidisci-plinary technology, and you would like to be consid-ered for inclusion in this symposium, please submit your abstract online and enter “3D” when prompted.

If your paper is accepted, SPIE will contact you to collect a 1-2 page summary explaining how your work can be used for an application area or can improve on current understandings. If your paper is selected by the 3D Printing committee, your presentation will be cross-listed in the SPIE Applications of 3D Printing Virtual Program and you will be eligible to win an SPIE Applications of 3D Printing Best Paper Award.

Symposium Chair:

Henry Helvajian, The Aerospace Corp. (USA)


CALL FOR PAPERS

General Information

VENUEThe Moscone Center 747 Howard Street San Francisco, CA 94103-3118 USASan Francisco is often called “Everybody’s Favorite City,” a title earned by its scenic beauty, cultural attractions, diverse communities, and world-class cuisine. Visitors rate the atmosphere and ambience as their top reason for visiting San Francisco. Mea-suring 49 square miles, this walkable city is dotted with landmarks like the Golden Gate Bridge, cable cars, and Alcatraz.

REGISTRATIONSPIE Photonics West registration will be available October 2014

All participants, including invited speakers, con-tributed speakers, session chairs, co-chairs, and committee members, must pay a registration fee. Authors, coauthors, program committee members, and session chairs are accorded a reduced sympo-sium registration fee.

Fee information for conferences, courses, a registra-tion form, and technical and general information will be available on the SPIE website in October 2014.

HOTEL INFORMATIONOpening of the hotel reservation process for SPIE Photonics West 2015 is scheduled for June 2014. SPIE will arrange special discounted hotel rates for SPIE conference attendees.

The website will be kept current with any updates.

STUDENT TRAVEL GRANTSA limited number of SPIE student travel grants will be awarded based on need. Applications must be received no later than 1 December 2014. Eligible applicants must present an accepted paper at this meeting. Offer applies to undergraduate/graduate students who are enrolled full-time and have not yet received their PhD.

CLEARANCE INFORMATIONIf government and/or company clearance is required to present and publish your presenta tion, start the process now to ensure that you receive clearance if your paper is accepted.

IMPORTANT NEWS FOR ALL VISITORS FROM OUTSIDE THE UNITED STATESFind important requirements for visiting the United States on the SPIE Photonics West website. There are new steps that ALL visitors to the United States need to follow.

Online at: www.spie.org/visa


By submitting an abstract, I agree to the following conditions:

ABSTRACT SUBMISSION

AN AUTHOR OR COAUTHOR (INCLUDING KEYNOTE, INVITED, ORAL, AND POSTER PRESENTERS) WILL:• Register at the reduced author registration rate

(current SPIE Members receive an additional discount on the registration fee).

• Attend the meeting.• Make the presentation as scheduled in the pro-

gram.• Submit a full-length manuscript (4 pages mini-

mum) for publication in the SPIE Digital Library and Proceedings of SPIE.

• Obtain funding for registration fees, travel, and accommodations, independent of SPIE, through their sponsoring organizations.

• Ensure that all clearances, including government and company clearance, have been obtained to present and publish. If you are a DoD contractor in the USA, allow at least 60 days for clearance.

Submit an abstract and summary online at : www.spie.org/bioscall • Abstracts should contain enough detail to clearly

convey the approach and the results of the re-search. Accepted abstracts will be published and made available at the meeting. Please submit a 250-word abstract for review.

• Please also submit a 100-word text summary suitable for early release. If accepted, this sum-mary text will be published prior to the meeting in the online or printed programs promoting the conference.

• Only original material should be submitted.• Abstracts should contain enough detail to clearly

convey the approach and the results of the re-search.

• Commercial papers, papers with no new research/development content, and papers where support-ing data or a technical description cannot be given for proprietary reasons will not be accepted for presentation in this conference.

• Please do not submit the same, or similar, ab-stracts to multiple conferences.

• TRANSLATIONAL RESEARCH: If your research is connected with improvements in healthcare and you want to participate in this virtual symposium, enter “TRANSLATIONAL” when prompted during the abstract submission. Accepted papers will be cross-listed in the SPIE Translational Research Virtual Program, and you will be eligible to win an SPIE Translational Research Best Paper Award. Award finalists will be contacted and asked to provide a 1-2 page summary explaining how the research is “translational.”

• 3D PRINTING: If your research is connected with 3D printing, manufacturing, or fabrication, enter “3D” when prompted during the abstract submission wizard. If your paper is accepted, SPIE will contact you to collect a 1-2 page sum-mary explaining how your work can be used for an application area or can improve on current understandings. If your paper is selected by the 3D Printing committee, your presentation will be cross-listed in the SPIE Applications of 3D Printing Virtual Program and you will be eligible to win an SPIE Applications of 3D Printing Award.

REVIEW, NOTIFICATION, AND PROGRAM PLACEMENT INFORMATION• To ensure a high-quality conference, all submis-

sions will be assessed by the Conference Chair/Editor for technical merit and suitability of con-tent.

• Conference Chair/Editors reserve the right to reject for presentation any paper that does not meet content or presentation expectations.

• The contact author will receive notification of acceptance and presentation details by e-mail the week of 6 October 2014.

• Final placement in an oral or poster session is subject to the Chairs’ discretion.

PROCEEDINGS OF SPIE AND SPIE DIGITAL LIBRARY INFORMATION• Manuscript instructions are available from the

“For Authors/Presenters” link on the conference website.

• Conference Chair/Editors may require manuscript revision before approving publication and reserve the right to reject for publication any paper that does not meet acceptable standards for a scientif-ic publication. Conference Chair/Editors’ decisions on whether to allow publication of a manuscript is final.

• Authors must be authorized to transfer copyright of the manuscript to SPIE, or provide a suitable publication license.

• Only papers presented at the conference and received according to publication guidelines and timelines will be published in the conference Proceedings of SPIE and SPIE Digital Library.

• Published papers are indexed in leading scientific databases including Astrophysical Data System (ADS), Chemical Abstracts (relevant content), Compendex, CrossRef, Current Contents, Deep-Dyve, Google Scholar, Inspec, Portico, Scopus, SPIN, and Web of Science Conference Proceed-ings Citation Index, and are searchable in the SPIE Digital Library. Full manuscripts are available to SPIE Digital Library subscribers worldwide.


INTERESTED IN EXHIBITING, SPONSORING AN EVENT, ADVERTISING WITH SPIE OR TO LEARN MORE•www.spie.org/biosexhibition

E.EXHIBITION

“BiOS Expo is not just for writing orders but also for keeping and strengthening relationships.”

- Vsevolod Mazo, Frankfurt Laser

Photonics West, 10–12 Feb. 2015, is the premier photonics and laser event. With more than 1,250 companies, this exhibition continues to be the flagship event to find the latest products, tools, and applications for your research or business needs. The exhibition sold out in 2014 with more than 1,250 companies.

BiOS EXPO7-8 Feb. 2015

Start your sales year at the largest biomedical optics and biophotonics exhibition.Experience BiOS EXPO — as the world’s largest event encompassing clinical, translational, and fundamental research and development in the field of biomedical optics and biophotonics, BiOS sits at the forefront of emerging technologies. Your booth will put you face-to-face with more than 5,000 weekend attendees and 210 exhibiting companies, plus access to a technical conference devoted to biomedical optics and biophotonics.

BiOS Expo is where you need to be to connect with customers in this growing industry. The BiOS Expo, held Saturday and Sunday, kicks off the Photonics West week, and is followed by the SPIE Photonics West Exhibition, held Tuesday through Thursday. Two world-class exhibitions—one venue.

- Grow your revenue

- Identify the hottest opportunities in the industry

- Connect with your customers

- Demo your new products

- Gain exposure with strategically placed advertising and sponsorships

The Moscone Center San Francisco, California, USA

DATES Conferences & Courses: 7-12 Feburary 2015

TWO EXHIBITIONS BiOS EXPO: 7-8 February 2015 Photonics West: 10-12 February 2015

Experience the unparalleled scope of SPIE Photonics WestAttend the premier technical event and marketplace for the photonics, biophotonics, and laser industry.

BiOS - Biophotonics: Topics include biomedical optics, photonic therapeutics and diagnostics, tissue engineering, translational research, tissue optics, clinical technologies and systems, biomedical spectroscopy, microscopy, imaging, nano/biophotonics.

Translational Research: Topics include the latest photonics technologies, tools, and techniques with high potential to impact healthcare.

LASE - Lasers and Sources: Topics include laser source engineering, nonlinear optics, semiconductor lasers and LEDs, laser manufacturing, laser micro-/nanoengineering, 3D fabrication, and more.

OPTO - Optoelectronic Devices and Materials: Topics include optoelectronic materials and devices, photonic integration, displays and holography, nanotechnologies in photonics, advanced quantum and optoelectronic applications, semiconductor lasers and LEDs, MOEMS-MEMS, optical communications: devices to systems.

Green Photonics: Topics include green photonics for solid state lighting and displays, laser-assisted manufacturing and micro/nano fabrication, communications, renewable energy generation: fusion and photovoltaics.

3D Printing: New track in 2015. This track will highlight papers from BiOS, LASE, and OPTO that showcase innovative ways to apply this multidimensional/multidisciplinary technology.

BiOS Expo: The world’s largest biomedical optics and biophotonics exhibition. The exhibition had more than 210 companies in 2014.

Photonics West Exhibition: The flagship event for companies in the photonics industry. The exhibition sold out in 2014 with more than 1,250 companies.

Present your work at Photonics West, the premier laser, photonics, biomedical optics conference: 20,000 attendees, two exhibitions, 1,250 exhibiting companies, a wide range of papers on biomedical optics, biophotonics, translational research, industrial lasers, 3D printing, optoelectronics, microfabrication, MOEMS-MEMS, displays, and more.

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BiOS - SPIE...+1 360 676 3290 • [email protected] • twitter (#PhotonicsWest) 1 2015 SYMPOSIUM CHAIRS: BiOS is the world’s largest international biomedical optics conference, encompassing