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Department of Neurosciences - Laboratory for Translational Neuropsychiatry
Center for Neuropsychiatry
Research Group Psychiatry
Department of Neurosciences
Biomedical Sciences Group
KU Leuven
Laboratory for Translational Neuropsychiatry
• Mission:
1) Understanding the pathogenesis of late life psychiatric
symptoms, especially the interplay between neurobiological,
psychological and social factors
2) Developping diagnostic tools for late life psychiatric
syndromes
3) Improving treatment: developing multidimensional
treatments, understanding the working mechanisms of existing
treatments, identifying prognostic factors, …
Late Life
Psychiatric Symptoms
LLPDMBI
FTDAD VD
LBDEOD LOD
LOP
Neurobiology
Multimodal Brain Imaging
MRI: GM, WM, activity, …
PET: Amyloid, Tau, Receptor, …
Genetics
Familial NCD
Behavior
Psychiatric assessment
Cognitive assessment
Social Cognition
Personality
Environment
Trauma
Life events
Family
Social isolation/integration
Education
Pharmacology
NT, vascular,
amyloid, …
Neuromodulation
ECT, rTMS, DBS
(Socio-)cognitive
revalidation
…
Family therapy
…
Ongoing projects: PESA-study
- Functional brain changes underlying emotion processing
presymptomatic carriers of pathogenic mutations of
neurodegenerative disorders (PESA; collaboration P. Van
Damme, K. Van Laere)
• - presymptomatic C9orf72 – mutations
• - longitudinal 2-year, 3 visits
• - behavioral assessment (psychiatric, cognitive,
psychophysics)
• - MRI/FDG-PET
• - fMRI: subsequent memory paradigm
encoding IR DR (48h) DR (1y) DR (2y)
Visit 1 Visit 2 Visit 3
• Construction of diagnostic tools for social cognition
assessement
• Emotion expression
• Emotion recognition
• Theory of mind
• Empathy
• Prosocial behavior
• …
Ongoing projects: SOCOS
Ongoing projects: Amyloid imaging in late life depression
Ongoing projects: Behavioral andneural correlates of prosopagnosia
Laboratory for Translational Neuropsychiatry
Ongoing projects: workingmechanisms of ECT
Laboratory for Translational Neuropsychiatry
Overview
• The role of PET-MRI neuroimaging in the differential
diagnosis of late-life depression and Alzheimer's Disease
(dr. Louise Emsell)
• De hersenbasis van emotionele veranderingen in FTD (dr.
François-Laurent De Winter)
• De psychologie en neurobiologie van laat ontstane
psychose (mevr. Lies Van Assche)
• De invloed van temporale pool resectie op het emotionele
brein (dr. Laura Van de Vliet)