berger phrases1

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Why the 4 code Genetic Primer Should Have 6 Nucleotide Codes

Inosine controls the "degradation" process

Inosine fulfills the first law of thermodynamics which states that energy or

matter is neither lost or gained in a chemical reaction but changes states

through phasesInosine two critical roles (IMP to ATP synthesis) plus responsible for the

entire degradation and recycling process qualifies it to be uracil'snucleotide

partner and the sixth and final nucleotide code

Inosine, itself, is the major "recycler" of "spent" amino acids (bases, sugars,

phosphodiesters)

IMP is the initiator of the nine step process which results in the synthesis ofATP (Adeno-Tri-Phosphate)

Inosine through its IMP (Inosine Mono-Phosphate) compound is the first purine tobe completed

we submit Inosine replaces adenosine when a new stem, branch or shape is

requiredironically dr. ferry won a nobel prize in 1953 for his discovery of thewobble position in the tRNA amino acid assembly process

Inosine takes the place of adenosine when the amino acid chain begins anon-linear "cloverleaf" directional change in the third anti-codon or z (height)

position, Inosine bonds with uracil, guanosine and cytosineThe substitution of U for T keeps the same number of genetic nucleotide codes

(i.e.) equal when DNA combines with RNA to form one of the twenty amino acids

found in every protein

The net difference in the substitution of U for T is the loss of 2 hydrogen

protons and the gain of one oxygen proton

The second major difference between d (deoxy-ribonucleic acid) DNA and

r(ribonucleic acid) RNA is RNA has one more furanose pentagonal ribose sugar

molecule

The net difference is H3-H1 = H2 or 2 hydrogen protons (H+)Thymine has a CH3 on position 6 of the C4N2 guanosine base while uracil hasonly a CH1

Inosine never bonds with thyminePrescription medications are the fourth leading cause of death in the United

States

300% more people die from medicines prescribed by their physician than in

automobile and motorcycle accidents

The current 4 dna nucleotide genetic codes are :1. (Adenosine=A), 2.

(Thymine=T), 3. (Guanosine=G) and 4. (Cytosine=C)

The current 4 rna nucleotide genetic codes are :1. (Adenosine=A), 2. (Uracil

= U), 3. (Guanosine=G) and 4. (Cytosine=C)

Uracil substitutes for Thymine in the current 4 code dna/rna amino acidsynthesis process

The DNA molecule resides in the nucleus of most if not all cell types

The RNA molecule resides and performs its functions outside the nucleus but

within the cellular walls

the future of medicine is based on the foundation of the double helix model

discovered in 1953 by waston and crick

all current genomic technologies are based on a four (4) code genetic primer

(dna = ATGC), (rna=AUGC)


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Car once the engine "starts" the starter or IMP role becomes less critical andis observed less frequently in intermediate metabolic processes

ATP is produced by oxidative phosphorylation in the Mitochondria, the power

generating plant organelle, in all plants and animals

would have to provide mission surival critical functionality

ATP is the universal energy molecule for all carbon based life forms

the genetic primer's 3 codon pairs specify the x (breadth), y(length) and z

(height) of the amino acid, polypeptide protein to be made

the main purpose of the genetic primer is to specify the generic type of stem

cell for exact shape and size and the exact atomic and molecular compound

compositions

the site on which the amino acid will be assembled by the ribosome

would be the third purine in joining adenosine and guanosinein the last codon position (x,y,z)

in the z position of the current watson crick bonding arrangements A-U is the

covalent pairing

would have to be able to bond to cytosine and uracil but not thyminetRNA the last of the three phases, insures the transfer and validity of the

codon and anticodon strands to be assembled in the ribosomes

ribosomal rna which is the actual physical interface of the biochemical

molecules (nucleotides) to the crystalline molecular substrate or base of the

amino acid assembly

messenger rna which decodes the dna instruction set, specifies

the exact sequence of codons

when the double helix hydrogen bonds which bond the

nucleotides together (A-T, G,C, I,U) is hydrolyzed

would have to provide a non-linear solution to amino acid sequence growth and

thus "budding"

uracil's missing partner would have to have these characteristics orproperties

Inosine and the "wobble effect" or wobble rules" were formulated by Dr. Francis

Crick, of double helix fame

what criteria might be used to determine the identity ofuracil

partner and

sixth nucleotide

before the substitution of U for T there were five total genetic codes

(A,T,G,C,U)

the third pairing would be uracil and ? the sixth and final nucleotidewhat advantage would a 6 code genetic primer have over a 4 code genetic primer

what would be the result of such a change in the current 4 code genetic primer

uracil's partner would have to be involved in the major metabolic processesand

amino acid synthesis

uracil's partner would have to provide essential, survival level functions andservices

since this is not how human life or any organic life increases the number in the

species in order to IMProve the chances of continued existence then it isfallacious to expect nature to use substitution and not addition in the dna to

rna transformation

in sexual reproduction addition not substitution is the mathematical process at

work

addition is nature's and therefore "the creators" algorithm for organic life,

growth and evolution

why would addition be more likely than substitution in the dna rna

transformation

what if addition were used instead of substitution as the primary dna to rna


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transformation

when uracil was found, what if science had found a partner for uracil insteadof

substituting uracil for thymine

if a partner were found for uracil that would make 6 and not 4 genetic codes

uracil's partner would certainly have to be found in amino acids and proteins

which are "downstream" from the nucleotide phasethe second pairing would be guanosine and cytosine (G-C)

the first pairing would be adenosine and thymine (A-T)Addition is more predictable than substitution

the purpose of the genetic code is to conserve and "pass down" successful

protein building plans which will increase the odds of survival and reproduction

the genetic code is a "blueprint" or master plan for constructing three

dimensional proteins

the final product of the nucleotide/dna/rna/amino acid synthesis process is the

construction of proteins and enzymes

addition would provide greater reliability and fidelity in conserving the

optimized protein building specifics such as location, composition and function

the use of substitution as the most reliable way to conserve the "wisdom of the

genes" as accumulated over 5 billion years of evolutionary "trial and error"learning is highly unlikely

a rational and logical designer would use addition and not substitution to

conserve the dna encoded survial lessons

one male sperm plus one female egg combine to create one unique life form

the male and female, numbered two

after the "offspring" was born there were now three human beings not two

if substitution was used for reproduction or genetic encoding then one of the

parents would be extincted and there would remain two unique life forms: (i.e.

one of the original parents and the offspring)

The substitution mathematical operator (i.e. Uracil (U) for Thymine (T) is asecondary mathematical process or genetic algorithm

The four fundamental, basic and most elemental math operators are 1. addition,

2. subtraction, 3. multiplication and 4. divisionthe substitution of uracil = U for Thymine = T is the only "code" differencebetween the dna and rna genetic codes

The substitution of uracil = U for Thymine = T is the only "code" differencebetween the DNA and RNA genetic codes

Every single prescription drug ever made has side effects

The current 4 RNA nucleotide genetic codes are :1. ((Adenosine=A), 2. (Uracil=

U), 3. (Guanosine=G) and 4. (Cytosine=C)

The current 4 DNA nucleotide genetic codes are :1. (Adenosine=A), 2.

(Thymine=T),

3. (Guanosine=G) and 4. (Cytosine=C)

The future of medicine is based on the foundation of the double helix modeldiscovered in 1953 by Watson and crick

The "almost " universal genetic code contains 64 unique 3 bit nucleotide codes

called codons or 192 total nucleotide bases

All current genomic technologies are based on a four (4) code genetic primer

(DNA = ATGC), (RNA=AUGC)

Violates Inheritance Laws

Violates Inheritance Laws

Purines

Guanosine Monophosphate


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GMP

Adenosine MonophosphateAMP

Adenosine Triphosphate ATP is the energy molecule which powers over 96% of allmetabolic reactions

Evolution Missing Purine Genetic Code

ADARADA

Xanthine Hydrolase

Xanthosine Oxidase

IMPDH2

IMPDH1HPGRT

IMPPurine Catabolic Degradation

Purine Synthesis Salvage

Pyrmidine Metabolism

First and Last Metabolic Process Steps in DNA and RNA Metabolism are certainly

critical metabolic roles

Inosine Family (XMP -xanthine oxidase) is final step purine catabolicmetabolism; removes toxic ammonia from central nervous system - especially

glutamate - the major excitatory nuerotransmitter in human brain

Inosine family (IMP) starts purine nucleotide synthesis which ultimately resultsin the RNA and DNA Molecules

Purines

Purine Nucleotide Anabolic Metabolism

Conversion of IMP to AMP and GMP in Purine Anabolic Metabolism from the firstclosed purine ring to ATP

Nucleotide Side Chains, Oxidation Initiation and Metabolic Cycle Patterns

Purine biosynthesis

Inosine Mono Phosphate

Urea Cycle Inherited Diseases, Arginine andInosine

Wobble CodonThere should be an orange purine in the genetic code especially since Inosine is

parent to ATP and GTP

The Wobble Codons are Key Metabolic Pathway Switches

The Necessity of the IMP Purine Nucleotide FamilyPurine ring wobble photonic diffraction Vectors

Purine Metabolism Map Color Zones and Wobble Codons

Arginine Inosine Wobble Diseases and the Citric Acid Cycl

Consequences omitting Parent Purine from Genetic Code

Conversion of IMP to AMP and GMP, IMP Parent Nucleotide, Belongs Genetic CodeFirst Purine Base and Closed Ring

First Purine Catalytic Enzymes Inosine

Fractal oxidation methyl group

Genetic code nucleotides and missing purine parent

Genetic code wrong omitted parent purine nucleotide base

IMP begins oxidation with AMP with no Oxygens

IMP building blocks purine synthesis

IMP First Enzyme Parent Purine

IMP first purine enzyme for purine synthesis

IMP initiates urea cycle stopping amino acid synthesis

IMP is clearly the parent purine and precursor of AMP and GMP


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IMP Root Purine Nucleotide Molecular Structure

IMPDH Inhibits RNA Synthesis

Initiator IMP nucleotide synthesis initiator

Inosine and side effects

Inosine anticodon position 34 and metabolic pathway-switching node

Inosinehas standard physical properties just like the other five nucleotide

genetic codes

Inosine key to decoding secrets of genetic script

Inosine Metabolic Functional Space used Purine Synthesis and Ammonia Removal

Inosine N34 stops amino acid and starts urea cycles removal toxic ammonia

Inosine orange functional boundaries

Inosine parent purine nucleotide

Inosine parent purine and triple helix genetic primer

Inosine Parent Purine Synthesis

Inosine parent purine to adenosine and guanosine

Inosine Purine Synthesis Central Internodal Connections

Inosine wobble codes and functional areas degraded in purine metabolismInosine Wobble, Arginine, and Urea Related Diseases

Nucleotides Compose Nucleic Acid Molecules

Nucleotides Purine Metabolism and Wobble Codes

Nucleotides, amino acids and Inosine wobble codes

Nucleotides, Genetic Code, Amino Acids and Inosine Wobble

Nucleotides, Purines, Inosine and the Missing Genetic Code

Omitting the Parent Purine Nucleotide Negates Evolutionary Inheritance for A and

G

Orange Inosine is parent to red adenosine and green guanosine

Oxygen and Inosine atomic molecular self-identity

Parent purine structure always remains in the derivative molecular compound

Purine anabolic and catabolic cycle start, stop and metabolic pathwayinterchanges

Purine closed ring molecular atomic donors and IMP synthesis

Purine Hierarchical Relationships Inosine Parent

Inosine Starter of Organic Purine Synthesis

AMP and GMP are made from IMP

AMP and GMP are formed from IMP the parent purine

Inosine Family

Inosine and IMP

amino acids coded by Inosine from the N34 position in the peptide chain

Urea Cycle Inherited Diseases, Arginine and Inosine Wobble Codon

The Wobble Codons are Key Metabolic Pathway SwitchesThe Logic of Nucleotide Molecular Inheritance

Purine Nucleotide Hiearchical Root Molecular Structure

Purine Ring Formation, IMP and InheritanceOmitting The Parent Purine Nucleotide Negates Evolutionary Inheritance for A and

G

Diseases from Missing Wobble Codon Amino Acids Arginine Serine Alanine

Inosine Wobble Genetic Codes and Amino Acid Codons

Current 5 Genetic Code Nucleotides Omitting Parent Purine IMP


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ATP & IMP mRNA Switch TCA to Urea CyclesPurine Nucleotide Anabolic to Catabolic Cycle Switch A to I Deaminase

Wobble Switch

IMP Starts ATP Synthesis

Inosine Parent Purine

The Purine Hexagonal Closed Ring Molecular Structure as the Foundation of The

Genetic CodeIMP is Parent Nucleotide Purine Molecular Structure of ATP

IMP Parent Purine

Inosine Family Genes, Enzymes, Proteins, and Wobble Amino Acids

DNA Hydrolysis by DNA deoxyInosine ( 3.2.2.15) glycosidase

Biosynthetic End Products from Alpha Ketoglutarate and Arginine

Xanthine Enzyme Multi-Function Nucleotide Compounds

Xanthine Oxidase Oxidation Mechanism and Uric Acid Eliminiation

Omitting The Parent Purine Nucleotide Base IMP is The Second Fatal Flaw of theCurrent Genetic Code

Natures Ingenious 3 bit Codon even Codes for bi-lateral Symmetry (i.e. left

and

right hands) Using the Dominant (5) and Recessive (3) NucleotideComplementary

Pairing made Famous by Watson and Crick

Each Purine-Pyrmidine Nucleotide Base Pairing (IMP-UMP, AMP-TMP, GMP-CMP) isthe X (width), Y (length) or Z (height) specification for making each of the 20

Standard Protein Amino Acids

Position Three is for the Z or Height Dimension and Contains three or

tri-phosphate esters with three hydrogen bonds

The Third Codon is Quite IMPortant Contrary to Conventional Genetic Code WisdomThe GMP-CMP Nucleotide Base Pair is the Third and Last Covalent Partnering of

the Novagon DNA Triple Helix 6 Code Genetic Primer

Position Two specifies the Y or length dimension and the Di-Phosphate Nucleotide

The Second Genetic Code Nucleotide Base Pair is AMP Covalently Bonded to TMP

with two hydrogen bonds

Position One of the Codon specifies the X dimension and one mono phosphate

The First Genetic Code Nucleotide Base Pair is IMP and UMP with one hydrogenbond

IMP is the Evolutionary Parent Purine Nucleotide for ITP, GTP and ATP

ATP had not been produced through phosphorylation before IMP began the PurineNucleotide Synthesis de novo Process

ATP is The Universal Energy Molecular Structure which Powers 96% of all

Metabolic Cycles

Inosine Mono Phosphate (IMP) - Was Natures First Purine Nucleotide MolecularStructure

Inosine Enzyme Nucleotide Compounds

Inosine Thermodynamic Parameters for Binding Drugs to DNA

Inosine Metal Binding and Ligand Stability Constants

IMP & XMP Metal Binding CofactorsPurine Nucleotide Family Inheritance Tree

Conversion of IMP to AMP and GMP is a Classic Parent Child InheritanceRelationship

IMP parent purine base nucleotide of ATP & GTP

Interconversion Purine Nucleotides by IMP Catalytic Starter ATP Synthesis

The IMP Purine Parent with his XMP Partner


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Purine Nulceotide Catabolic Metabolism

Metabolism of Ammonia

Eliminating Toxic Ammonia is a Survival Level Functions and Representation in

the Genetic Code

Purine Catabolic Degradation and Recycling

Purine Catabolic Metabolism and Uric Acid Toxic Ammonia Elimination

Purine Salvage and IMP Parent Purine Nucleotide Omitted in the Current GeneticCode

Urea Cycle, Toxic Ammonia Removal and Xanthine Oxidase Enzyme



There should be an orange purine in the genetic code especially since Inosine is

parent to ATP and GTP

The Wobble Codons are Key Metabolic Pathway Switches

The Necessity of the IMP Purine Nucleotide FamilyPurine ring wobble photonic diffraction Vectors

Purine Metabolism Map Color Zones and Wobble Codons

Arginine Inosine Wobble Diseases and the Citric Acid Cycl

Consequences omitting Parent Purine from Genetic Code

Conversion of IMP to AMP and GMP, IMP Parent Nucleotide, Belongs Genetic CodeFirst Purine Base and Closed Ring

First Purine Catalytic Enzymes Inosine

Fractal oxidation methyl group

Genetic code nucleotides and missing purine parent

Genetic code wrong omitted parent purine nucleotide base

IMP building blocks purine synthesis

IMP First Enzyme Parent Purine

IMP first purine enzyme for purine synthesis

IMP initiates urea cycle stopping amino acid synthesis

IMP is clearly the parent purine and precursor of AMP and GMP

IMP Root Purine Nucleotide Molecular Structure

IMPDH Inhibits RNA Synthesis

Inosine and side effects

Inosine anticodon position 34 and metabolic pathway-switching node

Inosine has standard physical properties just like the other five nucleotide

genetic codes

Inosine key to decoding secrets of genetic script

Inosine Metabolic Functional Space used Purine Synthesis and Ammonia Removal

Inosine N34 stops amino acid and starts urea cycles removal toxic ammonia

Inosine orange functional boundaries

Inosine parent purine nucleotide

Inosine parent purine and triple helix genetic primer

Inosine Parent Purine Synthesis

Inosine parent purine to adenosine and guanosine

Inosine Purine Synthesis Central Internodal Connections

Inosine Starter of Organic Purine Synthesis

Inosine wobble codes and functional areas degraded in purine metabolism

Inosine Wobble, Arginine, and Urea Related Diseases

Purine Hierarchical Relationships Inosine Parent


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Purine closed ring molecular atomic donors and IMP synthesisPurine anabolic and catabolic cycle start, stop and metabolic pathway

interchanges


Parent purine structure always remains in the derivative molecular compound

Orange Inosine is parent to red adenosine and green guanosine

Omitting the Parent Purine Nucleotide Negates Evolutionary Inheritance for A andG

Nucleotides, Purines, Inosine and the Missing Genetic Code




Oxygen and Inosine atomic molecular self-identity

Initiator IMP nucleotide synthesis initiator

AMP and GMP are made from IMP

IMP begins oxidation with AMP with no Oxygens

AMP and GMP are formed from IMP the parent purinePurine Nucleotide Anabolic Metabolism

Conversion of IMP to AMP and GMP in Purine Anabolic Metabolism from the firstclosed purine ring to ATP

Nucleotide Side Chains, Oxidation Initiation and Metabolic Cycle Patterns

Purine biosynthesis

Purine Nulceotide Catabolic Metabolism

Metabolism of Ammonia

Eliminating Toxic Ammonia is a Survival Level Functions and Representation in

the Genetic Code

Purine Catabolic Degradation and Recycling

Purine Catabolic Metabolism and Uric Acid Toxic Ammonia Elimination

Purine Salvage and IMP Parent Purine Nucleotide Omitted in the Current GeneticCode

Urea Cycle, Toxic Ammonia Removal and Xanthine Oxidase Enzyme

5-phosphoribosylamineClosed Ring Purine Synthesis de novo

IMP The First Purine Nucleotide "closed" ring Molecular StructureFirst Purine Nucleotide Closed Ring Structure and Purine Nucleotide Synthesis

First Closed Purine Nucleotide Ring IMPThe First Closed Purine Nucleotide Molecule Paved The Way for DNA and RNA to

Evolve

IMP The First Purine Nucleotide "closed" ring Molecular StructureFirst Purine Nucleotide Closed Ring Structure and Purine Nucleotide Synthesis

First Closed Purine Nucleotide Ring IMPThe First Closed Purine Nucleotide Molecule Paved The Way for DNA and RNA to

Evolve

Purine Nucleotide Family Inheritance Tree

Conversion of IMP to AMP and GMP is a Classic Parent Child InheritanceRelationship

IMP parent purine base nucleotide of ATP & GTP

Interconversion Purine Nucleotides by IMP Catalytic Starter ATP Synthesis

The IMP Purine Parent with his XMP Partner



There should be an orange purine in the genetic code especially since Inosine is


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AMP and GMP are formed from IMP the parent purine

Inosine Family Genes, Enzymes, Proteins, and Wobble Amino Acids

Inosine Enzyme Nucleotide Compounds

Inosine Thermodynamic Parameters for Binding Drugs to DNA

Inosine Metal Binding and Ligand Stability Constants

IMP & XMP Metal Binding Cofactors

DNA Hydrolysis by DNA deoxyInosine ( 3.2.2.15) glycosidase

Biosynthetic End Products from Alpha Ketoglutarate and Arginine

Xanthine Enzyme Multi-Function Nucleotide Compounds

Xanthine Oxidase Oxidation Mechanism and Uric Acid Eliminiation

Omitting The Parent Purine Nucleotide Base IMP is The Second Fatal Flaw of theCurrent Genetic Code

IMP is the Evolutionary Parent Purine Nucleotide for ITP, GTP and ATP

ATP did not Exist beforeIMP

began the Purine Nucleotide Synthesis Process

ATP is The Universal Energy Molecular Structure which Powers 96% of all

Metabolic Cycles

Inosine Mono Phosphate (IMP) - Was Natures First Purine Nucleotide MolecularStructure

Each Purine-Pyrmidine Nucleotide Base Pairing (IMP-UMP, AMP-TMP, GMP-CMP) isthe

X (width), Y (length) or Z (height) specification for making each of the 20

Standard Protein Amino Acids

Position Three is for the Z or Height Dimension and Contains three or

tri-phosphate esters with three hydrogen bonds

The Third Codon is Quite IMPortant Contrary to Conventional Genetic Code WisdomThe GMP-CMP Nucleotide Base Pair is the Third and Last Covalent Partnering of

the Novagon DNA Triple Helix 6 Code Genetic PrimerPosition Two specifies the Y or length dimension and the Di-Phosphate Nucleotide

The Second Genetic Code Nucleotide Base Pair is AMP Covalently Bonded to TMP

with two hydrogen bonds

Position One of the Codon specifies the X dimension and one mono phosphate

The First Genetic Code Nucleotide Base Pair is IMP and UMP with one hydrogenbond

Natures Ingenious 3 bit Codon even Codes for bi-lateral Symmetry (i.e. left

and

right hands) Using the Dominant (5) and Recessive (3) Nucleotide

Complementary

Pairing made Famous by Watson and Crick

Pyrmidines

Pyrmidine Nucleotides

Pyrmidine Nucleotide Anabolic Metabolism

Pyrmidine Nucleotide Catabolic Metabolism

Interconversions and Degradation of Pyrmidine Nucleotides and XMP Ribonucleases

Pyrmidine Metabolism, Thioredoxin Reduction and Nucleic Acid Polymerases

Genetic Code Violates Inheritance Laws - Omits Parent Purine Nucleotide -

Inosine Monophosphate (IMP) - Purine Synthesis De Novo " from scratch" -Purine and Pyrmidine "de novo" Metabolism Synthesized The First Evolutionary

Nucleic Acids (RNA & DNA)

"Closed Ring" allowed Photosynthetic Photons (electrons & protons) to be


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captured by closed crystalline molecular structure

IMP - First " Closed Purine Ring" Nucleotide made by NaturePurine Synthesis "de novo" -Most complex molecular structure synthesis in nature

- 14 dufferent enzymatic intermediate structures involved

Omits Parent Purine Nucleotide - Inosine Monophosphate (IMP)

IMP Begins Purine Synthesis De Novo

Purine Nucleotide Synthesis De Novo Makes Molecular Structures for DNA and RNAMolecules

AMP and GMP are Formed From IMPNucleotides

Thioester Phosphates

Pentose Sugars

Nitrogen Bases

Structures of Nucleotides and Nucleosides

ATP is the energy currency of metabolic reactions in cellular operations by

cellular organelles i.e. mitochdondria, ribosomes

Structures of Nucleotides and Nucleosides

Scientist discovered five different nucleotides (Adenosine, Thymine,

Guanosine,

Cytosine and Uracil)Remember in this substitution of U for T, 2 hydrogen protons (H2+) are lost and

one oxygen is gained

The number 2 (thymine) and number 5 (uracil) molecular structures are not thesame, they are not equivalent they are not interchangeable parts

The number 5 position or structure took the place of the number 2 position or

structure

The decision was made to substitute the fifth (5) =( Uracil = U) nucleotidefor

the second nucleotide (Thymine = T)These 5 nucleotides represent 5 different positions in the 230 space crystalline

lattice structure

These 5 nucleotides represent 5 different crystalline molecular structures

Nucleotides

Adenosine

Guanosine

Inosine

Xanthosine

Purine Nucleosides are composed of four major molecular structures

Inosine Purine Parent

Purine Bases

Pyrmidine Bases

Nucleosides are made up of nitrogen bases

Purine Nucleosides

Pyrmidine Nucleosides

Nucleotides are made up of nucleosidesPurine Nucleotide Bases

IMPAMP

GMP

IMP FamilyThe entire concept of inheritance and evolution rests on "new generations" (i.e.

GMP and AMP) of molecules starting with " a template" or organic molecular

structure; since Inosine was the first purine to possess the critical "closed


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ring" molecular structure and GMP and AMP are derived from IMP why wouldn't thefirst purine molecule be the first purine genetic code

IMP (E.C. = 1.1.1.1.250 is the lowest purine enzyme classification number whichmeans it came before all other purine enzymes;

Besides being the first enzyme, the first purine closed ring Inosine also has

the perfect molecular structure to start an oxidation-reduction biochemical

reaction between two chemical species i.e.Adenosine has no oxygen but only aNH2

(ammonium side radical)

ATP would never have evolved into it's present state and critical molecular

function if the parent IMP did not develop the closed purine ring

Omitting Inosine from the genetic code means eitherAdenosine or Guanosine istaking

its legitimate place in the linear sequence of amino acids/codons;

When A replaces I then the covalent pair lose their ability to be oxidized at a

lower temperature or energy state; this makes the cell take valuable energy from

other critical redox enzyme proteonic reactions

If Guanosine is substituted into a specific atomic amino acid cell site thenthe

molecule gets the O2 molecule for oxidation but also adds an NH2 or ammonium ion

which causes an imbalance in the ammonia/urea cycle elemination process which is

crucial for cellular heath; besides oxidation, ammonia is the dangerous threat

to the brain master control center

One has to assume in over 3.6 billion years that each nucleotide base code has

only one amino acid associated with it; the genetic code is not degenerate; it

is man's inability to use the more specific genetic information encoded in the

atomic genetic primer which is atom specific; ie. there are 230 possible node or

connecting points in the various three dimensional crystalline lattice

structures which make up the "frame " of the gene; since 1 helical spiral has 10

turns between purine base pairs then 230/10 = 23 chromosomes

DNA is half protein (histones) and half dna ; it should be possible to "map" the

exact location of the twenty three chromsomes over the three dimensional space

the crystalline structure extends; we have calculated the maxium number of basepairs that each of six nodes can have for the purine/pyrmidine nucleotides

If A and G, the children of I (IMP = GMP, AMP two different pathways); if the 2

children are in the genetic code then their common parent, Inosine or IMP mustalso be in the genetic code primer

Inosine is precursor IMP nucleotide to GMP and AMP or GTP and ATP ; two most

IMPortant energy sources for internal (GMP = dna /rna transcription andtranslation processes); ATP external or extrons to invidivual cell; is a network

charger = ATP

These are the "wobble" nucleotide base pairings Inosine forms (I) - (U,C,A) and

the three metabolic wobble "switched" anabolic and catabolic pathways

Purine Catabolic, Decomposition and Recycling Cycle (salvaging "left over"

purine bases, ribose sugar, and phosphodiester organic atoms for beginning IMPto ATP 9 step anabolic reaction

Inosine and the wobble position - anti-codon branching point for beginning of

catabolic purine process AMP + asparate = Inosine = IUG ; stop protein

synthesis; begin recycling and new set up for different amino acid;

Inosine can bond with Cystosine (first choice), Uracil (second choice) and take

the place ofAdenosine (adenosine deaminase = mRNA editing) - violationwobble tRNA

rule and central dogma linear model; numerous instances where both positive and


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negative feedback processes regulate macromolecular anabolic and catabolic

reactions

Inosine only purine base to be able to bond to three different partners; maximum

flexibility and IMProves purine pathways from 2 to 3; allows for feedbacksytems

to develop; one needs three objects or processes to make a comparison and

adjustmentThis is a metabolic map of purine metabolism showing the criticality of Inosine,

IMP, Xanthine, Hypoxanthine and all the "orange" metabolic nodes

Inosine Mono Phosphate - first purine "closed ring" hexagonal heterocyclic

benzymatic molecular structure; fundamental nucleotide of genetic code protein

primer

IMP is the precursor purine parent to ATP and GTP

IMP is first totally closed purine base ring

Inosine Mono Phosphate Parent Purine

IMP, precursor biochemical parent of AMP and GMP has the Perfect MolecularStructure and Optimal Number and Type of Purine Ring Side Atomic Molecular

Structures

There are two major metabolic cycles IMP or Inosine, hypoxanthine (base),xanthine (base), Inosine (nucleoside), Inosine monophosphate (nucleotide)

IMP is made from: 1. three amino acids (glycine, aspartate, and gluamine), 2. atetrahydrofolate cofactor (10 Formyl Tetrahydrofolate), 3. a Carbon Dioxide

(CO2), 4. PRPP (Phosphoribophosphate) - ribose sugar) with the IMPDH (inosinicacid -dehydrogenase enzyme E.C. = 1.1.1.1.250)

IMP has only "one" oxygen on its side chain; AMP has no Oxygen Atoms in the

Adenosine base Molecular Structure; since it has no oxygen's a self-bonding ofA-A

has two NH2 side chains but no Oxgen; it has to wait for the pentose/ribose

nucleoside sugar to connect to the adenosine base before it can becomemetabolically active

If the Two Purine Nucleotide Molecular Strutures of the "Children" of InosineMono Phosphate (1.1.1.1.250) are in the Present Genetic Code Then the Parent

Purine Nucleotide Molecular Structure must also be in that Same Genetic Code

IMP is the first purine nucleotide to have a "closed ring structure"

IMP is formed in a nine step synthesis from the following 6 different atomicmolecular donors

Glutamine, Glycine, Aspartate, N10 Formyltetrahydrofolate, CO2, PRPP

IMP, IDP, ITP

IMP begins purine metabolism which terminates with the production of thetriphosphates i.e. ATP, GTP, ITP

AMP Family

AMP-S, AMP, ADP, ATP,

ATP and GTP along with ITP are the purine nucleotides of the Genetic Primer

GMP Family

Purine Anabolic, Growth and Synthesis Cycle

Purine Nucleotide Synthesis

XMP, GMP, GDP,GTP

Urea Cycle

Arginine

Purine Nucleotides are composed of three major molecular structures with 3 or 4

isotopic alleles

These are the 12 nucleosides (6) and nucleotides (6) which make up the genetic


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codes which specify and coordinate protein synthesis

Purine Anabolic and Catabolic Biomolecular Metabolic Redox Reactions

Methyl- Inosine

Thio-Inosine

Hypoxanthine

Xanthine Oxidase

Inosine and IMP = Hydrogenase = 1.1.1.1.250Glutamine

Glycine

Aspartate 1

N10 Formyl

Tetrahydrofolate 1

CO2

Aspartate 2

N10 Formyl

Tetrahydrofolate 2

PRPP

Purine Nucleotide Closed Ring

IMP

XMPGMP

GDP

GTP

AMP-S

AMP

ADP

ATP

DNA

Nucleic Acid

ATPase

Water

Ammonia

AMP

IMPXMP

Xanthine Oxidase

Uric Acid

Urate

Ammonia

Eliminated

GMP

RNA

Nucleic Acid

RNA Genetic Code

A2 - U1

G2- C2

ATPNucleotide

UTP

Nucleotide

Adenosine Base

Uracil BaseDNA Genetic Code

A1 - T1

G1- C1


16/16

ATP

Nucleotide

TTP

Nucleotide

Adenosine Base

Thymine Base

A purine nucleotide with no side groups but hydrogens has 9 different and uniquebonding positions; even though a 6 and 5 sided (hexagon + pentagon) are fused

together, they share a common carbon bond thus substracting 2 sides, thus 11 -2

= 9 thus in the purine electrochemical circuit their are nine different

potential oxidation states each corresponding to sulfur's

(+6,+5,+4,+3,+2,+1,0,-1,-2 ); it is interesting to note that the maximum

positively c

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