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Aulani " Biokimia" Presentation2Aulani " Biokimia" Presentation2
Introduction to Introduction to MetabolismMetabolism
Aulanni’amAulanni’amBiochemistry LaboratoryBiochemistry LaboratoryChemistry DepartementChemistry Departement
Brawijaya UniversityBrawijaya University
Aulani " Biokimia" Presentation2Aulani " Biokimia" Presentation2
MetabolismMetabolism
Definition ?Definition ?
Metabolic pathways = network of linked Metabolic pathways = network of linked reactionsreactions
MetabolismMetabolism Catabolism (ATP production)Catabolism (ATP production) Anabolism (SyntheticAnabolism (Synthetic pathways) pathways)
Aulani " Biokimia" Presentation2Aulani " Biokimia" Presentation2
PROTEINPROTEIN POLISAKARIDAPOLISAKARIDA LIPIDLIPID BIOMOLEKULBIOMOLEKUL
ASAMASAM
AMINOAMINO GLUKOSAGLUKOSAGLISEROLGLISEROL
AS. LEMAKAS. LEMAK
MOLEKULMOLEKUL
PEMBANGUNPEMBANGUN
PIRUVATPIRUVAT
ASETIL-KoAASETIL-KoA
Tahap II
Tahap I
Tahap III
PRODUKPRODUK
PEMECAHANPEMECAHAN
UMUMUMUM
PRODUKPRODUK
KATABOLISMEKATABOLISME
SEDERHANASEDERHANACO2CO2H2OH2ONH3NH3
SIKLUS ASAMSIKLUS ASAM
SITRATSITRAT
PENTOSAPENTOSA HEKSOSAHEKSOSA
Aulani " Biokimia" Presentation2Aulani " Biokimia" Presentation2
Aulani " Biokimia" Presentation2Aulani " Biokimia" Presentation2
Metabolism of Energy Metabolism of Energy Containing NutrientsContaining Nutrients
CarbohydratCarbohydratee
PyruvatePyruvate
Acetyl CoAAcetyl CoA
Krebs CycleKrebs Cycle
ProteinProtein
Amino Amino AcidsAcids
FatFat
Fatty Fatty AcidsAcids
GlycerolGlycerol
Aulani " Biokimia" Presentation2Aulani " Biokimia" Presentation2
Biochemical PathwaysBiochemical Pathways
Aulani " Biokimia" Presentation2Aulani " Biokimia" Presentation2
How Cells Use EnergyHow Cells Use Energy
Adenosine Triphosphate (ATP) is the molecule in Adenosine Triphosphate (ATP) is the molecule in cells that supplies energy. cells that supplies energy. Five-carbon sugar (ribose)Five-carbon sugar (ribose) Adenine (nucleotide base)Adenine (nucleotide base) Chain of three phosphate groupsChain of three phosphate groups
Most energy exchanges in cells involve cleavage Most energy exchanges in cells involve cleavage of the outermost phosphate bond, converting ATP of the outermost phosphate bond, converting ATP into ADP and inorganic phosphate.into ADP and inorganic phosphate.
Aulani " Biokimia" Presentation2Aulani " Biokimia" Presentation2
ATP-ADP CycleATP-ADP Cycle
Aulani " Biokimia" Presentation2Aulani " Biokimia" Presentation2
Aulani " Biokimia" Presentation2Aulani " Biokimia" Presentation2
Kinetic EnergyKinetic Energy
EnergyEnergy in the process of doing work. in the process of doing work.
EnergyEnergy of of motionmotion..
Examples:Examples:
1.1. HeatHeat
2.2. Light energyLight energy SUN
Aulani " Biokimia" Presentation2Aulani " Biokimia" Presentation2
Potential EnergyPotential Energy
EnergyEnergy that matter occupies because of that matter occupies because of it’s location, arrangement, or position.it’s location, arrangement, or position.
EnergyEnergy of position. of position.
Examples:Examples:
1.1. Water behind a damWater behind a dam
2.2. Chemical energy (gas)Chemical energy (gas)GAS
Aulani " Biokimia" Presentation2Aulani " Biokimia" Presentation2
Hydrolysis of ATPHydrolysis of ATP
ATP + HATP + H22O O ADP + P (exergonic) ADP + P (exergonic)
HydrolysisHydrolysis(add water)(add water)
P P P
Adenosine triphosphate (ATPAdenosine triphosphate (ATP))
P P P++
Adenosine diphosphate (ADPAdenosine diphosphate (ADP))
Aulani " Biokimia" Presentation2Aulani " Biokimia" Presentation2
Dehydration of ATPDehydration of ATP
ADP + P ADP + P ATP + H ATP + H22O (endergonic)O (endergonic)
Dehydration synthesisDehydration synthesis
(remove water(remove water) )
P P P
Adenosine triphosphate (ATP)Adenosine triphosphate (ATP)
P P P++Adenosine diphosphate Adenosine diphosphate
(ADP(ADP))
Aulani " Biokimia" Presentation2Aulani " Biokimia" Presentation2