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Environmental Risk Assessment
Multi-disciplinary approach to the riskassessment of organic and
inorganic
chemicals in aquatic ecosystems.
Fate and effects of natural andsynthetic chemicals in both
fresh
water and marine systems (includingfood chain assessments).
Scientists actively involved in OECDand other international test
guideline
developments.
Chair UK NC3Rs (Replacement, Refinement
and Reduction) Regulatory ToxicologyCommittee (Ecotoxicology
Working Group).
OECD Endocrine Disrupters Testing &Assessment Working Group
(Ecotoxicology
Validation Management Group).
OECD Validation Management Group inEcotoxicology for test
guideline
development (Fish Experts Group).
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Environmental Chemistry and Fate
Extensive analytical chemistrycapabilities for metals,
nutrients,
organic chemicals and radionuclides,
including trace level environmental
analyses.
Wide range of in-house specialistfacilities including GC-MS,
GC-MS/MS,
GC-ECD, HPLC, ICP-MS and LC-MS/MS.
The high quality of Cefas science isreflected through
accreditation
(including GLP, ISO, MCERTS and
UKAS).
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Ecotoxicology and effects assessment
In depth skills in hazard assessment ofchemicals using a suite
of freshwater
and marine ecotoxcity tests .
Tests include:
In vitro assays (e.g. YAS, YES, CALUX)
Acute invertebrate testing (e.g.Daphnia magna OECD 202 and
211).
Chronic partial and full life cycle
invertebrate assays (shrimps,
copepods, oysters, and sediment
dwelling organisms)
Acute fish studies (e.g. OCED 203) Chronic and partial life
cycle fish
studies including zebrafish, rainbow
trout and sticklebacks (e.g. OECD 210,
212, 215)
Amphibian metamorphosis assay
(OECD 231).
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Environmental effects monitoring
Environmental monitoring is avaluable tool for environmental
risk
assessment (ERA) and environmental
impact assessment (EIA).
Field collection environmentalsamples (from point source to
ocean).
Biological effects testing .
Quality assured chemical analysis.
Effluent characterisation (Integrated
chemical fractionation and biological
effects screening).
Validation of fate effects modelling
data.
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TIE (Toxicity Identification Evaluation): identifying
causes of toxicity in complex samples
Complexmixture
Responsibletoxicant
Fractionation
Biologicalanalysis
Biological
analysis
Chemicalanalysis
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Bespoke testing systems
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Small teleost (easy to keep in the lab).
Present all around the North Hemisphere.
One of three species truly endemic to the
British Isles.
Fresh, estuarine, and marine waters
Well-documented biology.
Complete genome sequence (US), bridge
the gap between model and sentinel
species. Unique traits/tools for endocrine
disruption research and OECD type
testing (early life stage, juvenile growth
etc)
The stickleback as a sentinel and model species
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Spiggin assay
(androgens)
Testicular pathology:
Intersex (ovotestis)
Toxico-genomic platforms
Field monitoring
Linking biomarkers
to behaviour
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Chemical risk and population relevant endpoints
Sebire et al., (2008). The model anti-androgen flutamide
suppresses the expression of typical male
stickleback reproductive behaviour. Aquatic Toxicology 90 (1),
pp. 37-47.
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For further information please
contact:
[email protected]
[email protected]@cefas.co.uk
mailto:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]
