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84 th Annual AsMA Scientific Meeting Fluid Shifts in Space Is it all in our heads? Eye Model for Understanding Visual Changes in Spaceflight May 15, 2013

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Page 1: Annual AsMA Scientific Meeting Fluid Shifts in Space Is it ...asmameeting.org/asma2013_mp/pdfs/asma2013_present_426.pdf84th Annual AsMA Scientific Meeting Fluid Shifts in Space Is

84th Annual AsMA Scientific Meeting

Fluid Shifts in SpaceIs it all in our heads?

Eye Model for UnderstandingVisual Changes in Spaceflight

May 15, 2013

Page 2: Annual AsMA Scientific Meeting Fluid Shifts in Space Is it ...asmameeting.org/asma2013_mp/pdfs/asma2013_present_426.pdf84th Annual AsMA Scientific Meeting Fluid Shifts in Space Is

84th Annual AsMA Scientific Meeting

• This is independently funded research.

• I will not discuss off-label use and/or investigational use in my presentation.

Eye Model for UnderstandingVisual Changes in Spaceflight

2May 15, 2013

Disclosure Information

Page 3: Annual AsMA Scientific Meeting Fluid Shifts in Space Is it ...asmameeting.org/asma2013_mp/pdfs/asma2013_present_426.pdf84th Annual AsMA Scientific Meeting Fluid Shifts in Space Is

84th Annual AsMA Scientific Meeting

• Hyperopia • Papilledema

• Posterior globe flattening

• Choroidal folds

Eye Model for UnderstandingVisual Changes in Spaceflight

3May 15, 2013

Dual Channel Assumption

Spaceflight Pathology

Page 4: Annual AsMA Scientific Meeting Fluid Shifts in Space Is it ...asmameeting.org/asma2013_mp/pdfs/asma2013_present_426.pdf84th Annual AsMA Scientific Meeting Fluid Shifts in Space Is

84th Annual AsMA Scientific Meeting

• Hyperopia • Papilledema

• Posterior globe flattening

• Choroidal folds

Eye Model for UnderstandingVisual Changes in Spaceflight

4May 15, 2013

Dual Channel Assumption

Spaceflight Pathology

Page 5: Annual AsMA Scientific Meeting Fluid Shifts in Space Is it ...asmameeting.org/asma2013_mp/pdfs/asma2013_present_426.pdf84th Annual AsMA Scientific Meeting Fluid Shifts in Space Is

84th Annual AsMA Scientific Meeting

Eye Model for UnderstandingVisual Changes in Spaceflight

5May 15, 2013

Paradox in spaceflight

• No other symptoms of elevated ICP

• Central and peripheral venous pressures are reduced

• IOP initially increases in spaceflight

• No known reason for hyperopic shift

Earth explanations

• Increased intracranial pressure (ICP)

• Elevated venous pressures (edema, choroidal folds, and shortening of axial length)

• Reduced intraocular pressure (IOP)

Reducing Cognitive Load

Spaceflight Pathology

Page 6: Annual AsMA Scientific Meeting Fluid Shifts in Space Is it ...asmameeting.org/asma2013_mp/pdfs/asma2013_present_426.pdf84th Annual AsMA Scientific Meeting Fluid Shifts in Space Is

84th Annual AsMA Scientific Meeting

Eye Model for UnderstandingVisual Changes in Spaceflight

6May 15, 2013

Limited Capacity Assumption

Page 7: Annual AsMA Scientific Meeting Fluid Shifts in Space Is it ...asmameeting.org/asma2013_mp/pdfs/asma2013_present_426.pdf84th Annual AsMA Scientific Meeting Fluid Shifts in Space Is

84th Annual AsMA Scientific Meeting

Eye Model for UnderstandingVisual Changes in Spaceflight

7May 15, 2013

Combining Images and Data

3D Animation Software

Page 8: Annual AsMA Scientific Meeting Fluid Shifts in Space Is it ...asmameeting.org/asma2013_mp/pdfs/asma2013_present_426.pdf84th Annual AsMA Scientific Meeting Fluid Shifts in Space Is

84th Annual AsMA Scientific Meeting

Eye Model for UnderstandingVisual Changes in Spaceflight

8May 15, 2013

Combining Images and Data

Page 9: Annual AsMA Scientific Meeting Fluid Shifts in Space Is it ...asmameeting.org/asma2013_mp/pdfs/asma2013_present_426.pdf84th Annual AsMA Scientific Meeting Fluid Shifts in Space Is

84th Annual AsMA Scientific Meeting

Eye Model for UnderstandingVisual Changes in Spaceflight

9May 15, 2013

Animation

Page 10: Annual AsMA Scientific Meeting Fluid Shifts in Space Is it ...asmameeting.org/asma2013_mp/pdfs/asma2013_present_426.pdf84th Annual AsMA Scientific Meeting Fluid Shifts in Space Is

84th Annual AsMA Scientific Meeting

Eye Model for UnderstandingVisual Changes in Spaceflight

10May 15, 2013

Interactive

Page 11: Annual AsMA Scientific Meeting Fluid Shifts in Space Is it ...asmameeting.org/asma2013_mp/pdfs/asma2013_present_426.pdf84th Annual AsMA Scientific Meeting Fluid Shifts in Space Is

84th Annual AsMA Scientific Meeting

Eye Model for UnderstandingVisual Changes in Spaceflight

11May 15, 2013

Thank You

Caroline O’DriscollJay C. BuckeyJacob SwanDonna HughesJérémie St-Amand