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CORRELATION BETWEEN NSAIDs

AND PEPTIC ULCER IN ELDERLY

Amelia Christiana

030.08.021

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INTRODUCTION

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PEPTIC ULCER

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GASTRODUODENAL MUCOSAL

DEFENSE

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SYNTHESIS PROSTAGLANDINE

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WHY NSAID MOST USE IN ELDERLY?

TAKING CONTINOUSLY

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SOME EXAMPLE OF NSAIDs

indomethacin ketorolac ketoprofen nabumetone

naproxen oxaprozin sulindac tolmetin

piroxicam ibuprofen Aspirin etodolac,

diflunisal diclofenac celecoxib

http://www.medicinenet.com/script/main/art.asp?articlekey=766http://www.medicinenet.com/script/main/art.asp?articlekey=44619http://www.medicinenet.com/script/main/art.asp?articlekey=799http://www.medicinenet.com/script/main/art.asp?articlekey=822http://www.medicinenet.com/script/main/art.asp?articlekey=795http://www.medicinenet.com/script/main/art.asp?articlekey=734http://www.medicinenet.com/script/main/art.asp?articlekey=721http://www.medicinenet.com/script/main/art.asp?articlekey=846http://www.medicinenet.com/script/main/art.asp?articlekey=750http://www.medicinenet.com/script/main/art.asp?articlekey=792http://www.medicinenet.com/script/main/art.asp?articlekey=697http://www.medicinenet.com/script/main/art.asp?articlekey=778http://www.medicinenet.com/script/main/art.asp?articlekey=743http://www.medicinenet.com/script/main/art.asp?articlekey=859http://www.medicinenet.com/script/main/art.asp?articlekey=8257http://www.medicinenet.com/script/main/art.asp?articlekey=8257http://www.medicinenet.com/script/main/art.asp?articlekey=859http://www.medicinenet.com/script/main/art.asp?articlekey=743http://www.medicinenet.com/script/main/art.asp?articlekey=778http://www.medicinenet.com/script/main/art.asp?articlekey=697http://www.medicinenet.com/script/main/art.asp?articlekey=792http://www.medicinenet.com/script/main/art.asp?articlekey=750http://www.medicinenet.com/script/main/art.asp?articlekey=846http://www.medicinenet.com/script/main/art.asp?articlekey=721http://www.medicinenet.com/script/main/art.asp?articlekey=734http://www.medicinenet.com/script/main/art.asp?articlekey=795http://www.medicinenet.com/script/main/art.asp?articlekey=822http://www.medicinenet.com/script/main/art.asp?articlekey=799http://www.medicinenet.com/script/main/art.asp?articlekey=44619http://www.medicinenet.com/script/main/art.asp?articlekey=766

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RISK FACTOR NSAIDs ULCER

AGE

DURATION AND DOSE THERAPY

COTHERAPY WITH OTHER DRUG

STRESS

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REFERENCES

Soll AH, Graham DY. Textbook of Gastroenterology: Peptic Ucer.West Sussex : Willey Blackwell Publishing; 2009. p. 936-1004.

Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL,Loscalzo J. Harrison's principles of internal medicine (17th ed.). NewYork: McGraw-Hill Medical Publishing Division; 2008.p. 1645-1660.

Takezono Y, Joh T, Oshima T, Suzuki H, Seno K, Yokoyama Y,Alexander JS, Itoh M. Role of prostaglandins in maintaining gastricmucus-cell permeability against acid exposure. J Lab Clin Med.2004. 143: 5258.

Tanaka A, Araki H, Komoike Y, Hase S, Takeuchi K. Inhibition of bothCOX-1 and COX-2 is required for development of gastric damage inresponse to nonsteroidal anti-inflammatory drugs. J Physiol. 2001.95: 2127.

Laine L. Approaches to non-steroidal anti-inflammatory drug use inthe high-risk patient. Gastroenterology. 2001. 120: 594596.

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REFERENCES

Baumgartner HK, Starodub OT, Joehl JS, Tackett L, Montrose MH. Cyclooxygenase 1is required for pH control at the mouse gastric surface. Gut. 2004. 53: 17511757.

Jaworski T, Sarosiek I, Sostarich S, Roeser K, Connor M, Brotze S, Wallner G,Sarosiek J. Restorative impact of rabeprazole on gastric mucus and mucinproduction impairment during naproxen administration: its potential clinicalsignificance. Dig Dis. 2005. Sci 50: 357365.

Darling RL, Romero JJ, Dial EJ, Akunda JK, Langenbach R, Lichtenberger LM. Theeffects of aspirin on gastric mucosal integrity, surface hydrophobicity,prostaglandin metabolism in cyclooxygenase knockout mice.Gastroenterology.2004. 127: 94104.

Graham DY, Agrawal NM, Campbell DR, Haber MM, Collis C, Lukasik NL, Huang B.Ulcer prevention in long-term users of nonsteroidal anti-inflammatory drugs:results of a double-blind, randomized, multicenter, active- and placebo-controlled

study of misoprostol vs lansoprazole. Arch Intern Med. 2002. 162: 169

175. Ma L, Elliott SN, Cirino G, Buret A, Ignarro LJ, Wallace JL. Platelets modulate gastric

ulcer healing: role of endostatin and vascular endothelial growth factor release.Proc Natl Acad Sci USA. 2001. 98: 64706475

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