ALDA RISMA CASE

KELOMPOK 5DINA SEPTIA

NINGSIHJERRY FEBRIALDINO

FEBRI LUSIANASHERLY OCTIZA

VICTIM ANAMNESA

1. Alcohol consumer

2 Often use barbiturate at the same time with alcohol

3. Using drug which make slender of type of amphetamine and metamphetamine by injection

Drug list which is used before her death

Amphetamine

Barbiturate ( Dormicum )

OMZ ( omeprazol)

Neurobium

Diazepam

Propovol

RESULT OF VISUM CORPSE VICTIM

o In stomach : liquid shabu

o At kidney and bile : morphine

o At urine : and amfetamin of metamfetamin high rate o At body was found propovol and benzodentin that was represented the root cause death

PHARMACOKINETICS OF DORMICUM ( MIDAZOLAM)

Activity of this medicine is quick that is in 30 minute and stay until 5-7 hours. Midazolam was bound

plasma protein counted 96%.Reorganizing allows quickly and perfection ( 60-80%) becoming final

metabolite 1-hydroksimethyil-midazolam which is released to pass urin in the form of glukuronida. plasma of T 1 / 2 - its very short that is 1,5-2,5

[hours of metabolit finally 60-80 minute

Barbiturate : 7,5-15 mg ( maleat) local Anaesthesia Pramedication : oral 25 minute mg45 ; 1ntramuskular 5 mg ( chloride) Side Effects : if exceeding dose above can cause resistance in respiration of which can become fatally

DOSES

PHARMACOKINETICS OF OMEPRAZOL ( OMZ)

Blocking of acid exretion do not depended from plasma rate, but from surface under curve ( AUC). Its Reabsorption is complete, for 2-5 hours. It has high Protein plasma ( 95%), t1/2 plasma its only more or less 1 hour but its activity stay 24 hour. At heart, this

substance is reorganized entirely become inactive metabolites, which is excreted by urine to 80%.

Between blood and its effect do not have correlation.

Omeprazol ravelled in acid atmosphere so that require to be given by acid proof cladding.

Side effects : head pain, muscle pain, sleepless, Eliminasi of and diazepam of fenitoi pursued

PHARMACOKINETICS OF DIAZEPAM

AT USAGE OF ORAL AND IN CLYSMA, ITS REABSORPTION IS GOOD AND QUICKLY, BUT

IMPERFECT AND SLOW IN THE FORM OF SUPPOSITORIA. ABOUT WAS BOUND WITH PLASMA PROTEIN. IN LIVER, WAS CHANGE

DIAZEPAM BECOME N-ACEHYILDIAZEPAM WHICH IS ACTIVE ALSO WITH PLASMA OF T ½ IS LONG,

THAT IS ABOUT 42-120 HOURS. T ½ PLASMA DIAZEPAM ONLY RANGING FROM 20-54 HOURS.

PHARMACOKINETICS OF PROFOLOL

Blocking of acid exretion do not depended from plasma rate, but from surface under curve ( AUC). Its Reabsorption is complete, for 2-5 hours. It has high Protein plasma ( 95%), t1/2 plasma its only more or less 1 hour but its activity stay 24 hour. At heart, this

substance is reorganized entirely become inactive metabolites, which is excreted by urine to 80%.

Between blood and its effect do not have correlation.

ANALYSIS CASE

•Usage of alcohol in a state of empty stomach can improve acid of gastric and to decrease it, was given omeprazol. This drug can degrade acid quickly and strongly by resistance pump proton.

•Consumption barbiturate which have long time with at the same time alcohol will improve barbiturate activity which caused poisoned

•Usage of drug which made slender contains amfetamin and metamfetamin will stimulate CNS, increase heart frequency and blood pressure.

•represent symptom of hipoksia. To overcome recuring Usage of this amfetamin caused tolerance

because condition of overdosis, arise painful and spasm then is given neurobion, but it is not effective.

Giving high dose of diazepam ( 400 iv mg). It can more serious condition of hipoksia and cause to desist breath at once

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