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This documentation is reserved to the professional corps. The information contained herein is based on our knowledge at the moment of going to press. The user is advised to ensure the suitability and completeness of this information in relation to the specific use that is to be made of it. The information given must not be considered a guide to self-medication. Users are invited to discuss the information with Doctors, Pharmacists or an authorised Personal Physician. Facts, studies and claims are the result of bibliographic research carried out on individual plants drugs. The editorial team is not responsible for typographical or typing errors.

DENPAS S.r.l. 37047 S. Bonifacio Verona (Italy)www.denpas.it

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AdapthaAge Dietary supplement in liquidform with antioxidant and anti-ageing action.Useful for protecting cells and tissuesfrom damage caused by free radicals.Instructions for use. Spray directly underthe tongue and the oral cavity from 5 up toa maximum of 10 times, as required during the day (equal to a maximum of 2 grams of product). Spread well around the mouth. Ingredients. Water, Echinacea roots (Echinacea angustifolia), Eleuterococcus roots (Acanthopanax senticosus), Hawthorn flowers and leaves (Crataegus oxyacantha), Pomegranate fruits (Punica granatum), Grapefruit fruits (Citrus grandis), Schisandra fruits (Schisandra chinensis), Curcuma root stocks (Curcuma Longa), Rowan fruits (Sorbus aucuparia), Rhodiola roots (Rhodiola rosea), Mangosteen fruits (Garcinia Mangostana), Acidifier, Citrus acid.WITHOUT PRESERVATIVES AND WITHOUT ADDED SUGARS

30ml

NUTRITIONALCONTENT OFTHE PRODUCT

le: liquid extractde: dry extract

g pe

r 10

0 gr

ams

mg

per

max

dos

e

Echinacea le 9,4 188Eleuterococcus le 7,5 150Hawthorn le 5,0 100Pomegranate juice 4,6 92Grapefruit juice 3,5 70Schisandra le 2,5 50Curcuma le 2,0 40Rowan le 1,0 20Rhodiola de 1,0 20Mangosteen de 0,1 2

Shake before use.The presence of light sedimentis an intrinsic feature of the product.It is recommended to keep withinthe indicated doses and not exceedthem in usage. Taking dietary supplements should not be consideredas a substitute for a varied diet.Do not take the product during pregnancy. Keep out of the reachof children under three years of age.Once opened, consume within 30 days.

agewith antioxidantand anti-ageingaction

dapthaadaptogen spray

49 - AdapthaAge

This documentation is reserved to the professional corps. The information contained herein is based on our knowledge at the moment of going to press. The user is advised to ensure the suitability and completeness of this information in relation to the specific use that is to be made of it. The information given must not be considered a guide to self-medication. Users are invited to discuss the information with Doctors, Pharmacists or an authorised Personal Physician. Facts, studies and claims are the result of bibliographic research carried out on individual plants drugs. The editorial team is not responsible for typographical or typing errors.

Adaptogen spray

AdapthaAge

Adaptogens

EchinaceaEchinacea angustifolia

Family: Compositae

Synonym: rudbeckia, purple coneflower.

Part used: the roots.

Popular and herbalist tradition: Echinacea is an adaptogenic plant that improves the resistance of the organism to external attacks by stimulating the immune system. Originally from the western North American plains, Echinacea is traditionally used for its properties of stimulating the immune system. Native Americans used echinacea for its properties of purifying the blood and for the treatment of numerous conditions: infections, wounds, eczema, rheumatism, syphilis, haemorrhoids and also as a general painkiller. At the beginning of the 20th century, European and American herbalists used this plant to treat viper bits and certain infectious illnesses such as typhoid and diptheria. In the twenties, it lost popularity with the arrival of synthetic drugs, nevertheless today it is one of the most widely used remedies for reinforcing the natural defences of the organism, especially against seasonal indispositions such as colds, influenza, coughs and seasonal allergies.

Principle ingredients: polyphenic compounds derived from caffeic acid: echinacoside, chicory acid, chlorogenic acid. Essential oil: polyacetylene compounds, N-isobutylamide Polysaccharides of high molecular weight.

Activity: adaptogen with immuno-stimulant characteristics, generally indicated for problems linked to winter ailments, a tonic.

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This documentation is reserved to the professional corps. The information contained herein is based on our knowledge at the moment of going to press. The user is advised to ensure the suitability and completeness of this information in relation to the specific use that is to be made of it. The information given must not be considered a guide to self-medication. Users are invited to discuss the information with Doctors, Pharmacists or an authorised Personal Physician. Facts, studies and claims are the result of bibliographic research carried out on individual plants drugs. The editorial team is not responsible for typographical or typing errors.

EleuterococcusAcanthopanax senticosus Maxim

Family: Araliacee

Synonyms: Siberian ginseng, devil’s stick.

Part used: rhyzome and roots.

Popular and herbalist tradition: the botanic name of the family of eleuterococcus is “Acantopanax” where: Acanto means “thorny” - Panax means “panacea.” The modern story of this plant begins with Brekham, in the forties, who, in the course of research to find an alternative to ginseng, discovered that eleuterococcus offered many of the benefits of the very famous Chinese and Korean product. Later research by Soviet and Chinese scientists has shown that eleuterococcus is a tonic-adaptogen with peculiar characteristics often even greater than those of the Chinese root (for example, at the level of the immune system). It is still well known for its use to aid the performance of the Russian athletes at the Moscow Olympics and for cosmonauts during long periods in space. Eleuterococcus is traditionally indicated as a tonic to reinforce the body during exertions and as a remedy against debilitation and the tendency of diminished working capacity and concentration, and during convalescence. It possesses a general action of stimulating the immune system.

Principle ingredients: eleuterosides, polysaccharides, phenolic compounds (coumarins, lignans, phenilpropans).

Activity: adaptogen, anti-asthenic, anti-stress, tonic.

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This documentation is reserved to the professional corps. The information contained herein is based on our knowledge at the moment of going to press. The user is advised to ensure the suitability and completeness of this information in relation to the specific use that is to be made of it. The information given must not be considered a guide to self-medication. Users are invited to discuss the information with Doctors, Pharmacists or an authorised Personal Physician. Facts, studies and claims are the result of bibliographic research carried out on individual plants drugs. The editorial team is not responsible for typographical or typing errors.

HawthornCrataegus oxyacantha

Family: Rosaceae.

Synonyms: hawthorn, bossolin, spinapulce, calaringhe.

Parts used: flowers and leaves.

Popular and herbalist tradition: used in Europe since the Middle Ages, popular medicine indicates hawthorn as a sedative remedy for the Central Nervous System and it is recommended for heart and circulation disturbances. Western herbalists consider it to be “food for the heart” because it increases the flow of blood to the heart and regulates its beat. Moreover, it is present in various medicinal preparations against insomnia and nervous conditions. Hawthorn displays a recognised sedative and muscle relaxant action which makes it particularly indicated for states of stress and anxiety. It has been demonstrated that its administration brings a calming effect on the central nervous system, being especially indicated in cases of sleep disturbances and in conditions characterised by excessive emotionality and anxiety, in stress and in the menopause. It has also been confirmed that the plant contributes to the elimination of the emotional elements of certain states of hypertension. The studies carried out reveal an important action on the cardiovascular system with a real improvement in resistance to exertion.

Principle ingredients: flavonoids including hyperosid and vitexin, triterpenoid compounds including ursolic acid, amine, sterols; tannin and purine derivatives.

Activities: invigorating, antidiarrhoeal, hypotensive and cardiotonic.

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This documentation is reserved to the professional corps. The information contained herein is based on our knowledge at the moment of going to press. The user is advised to ensure the suitability and completeness of this information in relation to the specific use that is to be made of it. The information given must not be considered a guide to self-medication. Users are invited to discuss the information with Doctors, Pharmacists or an authorised Personal Physician. Facts, studies and claims are the result of bibliographic research carried out on individual plants drugs. The editorial team is not responsible for typographical or typing errors.

SchisandraSchisandra chinensis

Famiglia: Schisandraceae.

Synonyms: Wu Wei Zi, Schizandra japonica.

Parts used: the fruit.

Popular and herbalist tradition: It is a deciduous and evergreen climber, of great development, with scented flowers and fruit similar to berries, widespread in eastern Asia and eastern North America, and introduced in the gardens of the West around 1850. The name Schisandra derives from the Greek, skhisis, “separation, fissure” and andros, “male,” referring to the garish dehiscence of the two anther pods. The Chinese name, “Wu Wei Zi” means “plant with 5 flavours” because, according to the system of traditional Chinese medicine, this plant contains all the flavours that regulate the effects of food on the body. Representative experiments showing the adaptogen action of Schisandra were conducted in the Soviet Union with volunteers from various professions; fighter pilots, wireless operators, athletes and intellectuals. The results were extremely positive with an improvement in performance, both physical and intellectual, with greater clarity of action and greater resistance to fatigue.

Principle ingredients: active schisandrina (methyl ester of polyphenols).

Adaptogen: lignans (7% to 19.2%); sugars; tannins; essential oil; organic acids (citric acid and tartaric acid); vitamins (vitamins C and E); minerals (copper, manganese); micro elements (nickel, zink, traces of titanium and silver).

Activities: detoxicant, tonic, astringent, adaptogen, stimulant, hepatoprotective antioxidant.

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This documentation is reserved to the professional corps. The information contained herein is based on our knowledge at the moment of going to press. The user is advised to ensure the suitability and completeness of this information in relation to the specific use that is to be made of it. The information given must not be considered a guide to self-medication. Users are invited to discuss the information with Doctors, Pharmacists or an authorised Personal Physician. Facts, studies and claims are the result of bibliographic research carried out on individual plants drugs. The editorial team is not responsible for typographical or typing errors.

RhodiolaRhodiola rosea

Family: Crassulaceae.

Part used: the roots.

Synonyms: golden root.

Part used: the roots.

Popular and herbalist tradition: traditionally used in Nordic countries to increase physical resistance and immunity, and longevity of the individual, Rhodiola has an almost legendary history. In Siberia, roots are administered to couples before marriage to promote the birth of healthy children. Rhodiola, believed to be a powerful stimulant, was used in the formulation of various love potions; the Ukrainian prince, Galitsky, who lived in the 13th century, boasted of being a great lover thanks to the roots of Rhodiola. For many centuries, Chinese emperors, who used the root to treat many different disturbances and illnesses, sent expeditions to eastern Siberia in search of the area where Rhodiola grew spontaneously. The first scientific studies on Rodiola date back to the first half of the last century, when groups of Russian scientists began to observe the effects of this plant; it was only in the early years of the sixties that information about the benefits and properties of Rhodiola was made public in the western world.

Principle ingredients: glycosidic phenolic compounds (rosavin, rosin, rosarin, salidoris), organic acids (oxalic, citric, malic, succinic, gallic), monoterpenes, beta-sitosterol, essential oils, mineral salts.

Activities: adaptogen, anti-stress, useful in the control of body weight when associated with a balanced diet. Improves the concentration, lucidity and mnemonic potential; indicated in the treatment of asthenia, depression, apathy, stress, muscular weakness and to optimise sporting performance by reducing the duration of the recovery phase.

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This documentation is reserved to the professional corps. The information contained herein is based on our knowledge at the moment of going to press. The user is advised to ensure the suitability and completeness of this information in relation to the specific use that is to be made of it. The information given must not be considered a guide to self-medication. Users are invited to discuss the information with Doctors, Pharmacists or an authorised Personal Physician. Facts, studies and claims are the result of bibliographic research carried out on individual plants drugs. The editorial team is not responsible for typographical or typing errors.

Fruits

PomegranatePunica granatum

a precious concentrate of antioxidant substances (polyphenols derived from ellagic acid), organic acids, minerals (calcium, iron, magnesium, phosphorous, potassium, copper and sulphur), vitamins (robiflavin, thiamine, vitamin B6, niacin, pantothenic acid, beta-carotene). The juice of the pomegranate combines recognised antioxidant, re-mineralising and vitamin properties with a pleasurable and refreshing taste.

GrapefruitCitrus grandis

Rich in flavonoids, pectins, vitamins of group B, vitamin C, pantothenic acid and organic acids, it possesses the organoleptic and nutritional qualities of citrus fruit.

MangosteenGarcinia mangostana

Garcinia mangostana, commonly known by the name, Mangosteen, is a typical fruit from the vast area of South-East Asia, belonging to the family of the Guttifere, and widespread in countries like Thailand, India, Malaysia, Vietnam and the Philippines, but also Australia and Hawaii. The benefits of this fruit with its pleasurably acidic flavour have recently been brought to light by studies that have revealed its marked antioxidant and immuno-modulating action.

RowanSorbus aucuparia

The name “aucuparia” (from the Latin, aiucupium: fowling) derives from the fact that, the berries being much loved by small migratory birds, it was traditionally used in traps in hunting such prey. Dried service tree fruit (also called sorb or whitty pear), in the past, was mixed with flour to enrich the bread at times of scarcity. Containing derivatives of parasorbic acid which determines the natural antifungal and anti-bacterial actions.

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This documentation is reserved to the professional corps. The information contained herein is based on our knowledge at the moment of going to press. The user is advised to ensure the suitability and completeness of this information in relation to the specific use that is to be made of it. The information given must not be considered a guide to self-medication. Users are invited to discuss the information with Doctors, Pharmacists or an authorised Personal Physician. Facts, studies and claims are the result of bibliographic research carried out on individual plants drugs. The editorial team is not responsible for typographical or typing errors.

Functionalizing

CurcumaCurcuma longa

The term OXIDATIVE STRESS refers to changes in the normal intracellular balance between oxidising substances, produced physiologically during the metabolic processes, and the anti-oxidant defence system that carries out the function of neutralising them [Sies (1985)]. The anti-oxidant system comprises enzymatic mechanisms and nonenzymatic mechanisms. Among the former are the superoxide dismutase, catalase and glutathione. Among the nonenzymatic substances are Vitamans E and C, the carotenoids, polyphens, antocianins etc. The main sorts of oxidants are the free radicals, substances derived from molecular oxygen, characterised by the presence of uncoupled electrons. The reactive types of oxygen (ROS), such as H2O2, the OH° and O° radicals, under normal conditions, carry out important physiological functions by intervening in the processes of the growth and deaths of cells in the inflammatory responses, but can also cause major cell damage; the balance between the physiological functions and damage is determined by the respective ratio between production and removal of the ROS. Normally, these types are rapidly removed before they can cause cellular dysfunction and eventual death. Numerous physiological and pathological processes (inflammation, infections, carcinogenesis, ageing, vitamin deficiency, metabolism problems) and similarly environmental factors may throw out of balance the production of oxidising substances and compromise the system of anti-oxidant defence and compromise the main cellular components of response such as fats, proteins, carbohydrates and DNA, with all the functions connected to them. In addition to the normal biochemical reactions of cellular oxidation, the following contribute to the formation of free radicals:

certain dysfunctions and pathological conditions. 1. the reduction of the carrying of blood to the tissue; 2. diets too rich in proteins and saturated animal fats; 3. non-tolerated foodstuffs; 4. excess of iron which, in the early phase of the transformation, the cause of 5. the liberation of the radical hydroxyl from hydrogen peroxide; the action of gas pollution and toxic substances in general (carbon 6. monoxide, heavy metals, hydrocarbons);

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This documentation is reserved to the professional corps. The information contained herein is based on our knowledge at the moment of going to press. The user is advised to ensure the suitability and completeness of this information in relation to the specific use that is to be made of it. The information given must not be considered a guide to self-medication. Users are invited to discuss the information with Doctors, Pharmacists or an authorised Personal Physician. Facts, studies and claims are the result of bibliographic research carried out on individual plants drugs. The editorial team is not responsible for typographical or typing errors.

cigarette smoke; 7. excess alcohol; 8. ionizing radiation and solar radiation (excessive ozone and UVA and UVB 9. rays). 9. Solar radiation induces in the skin processes of photo-oxidation which degrade the polyunsaturated fatty acids of the cellular membrane with the consequent formation of free radicals;certain pharmaceuticals; 10. intense physical activity, both organic resistance and muscular force, cause 11. a notable increase in the reactions that use oxygen (increase in pulmonary breathing and the mitochondrial activities of the muscle cells etc.) and the consequent surplus of the formation of hydrogen peroxide.

Formazione dei radicali liberi

Radiations

DNA damage

Ultraviolet radiations

Metabolism

Inflammations

White blood cells

Pollution

Smoke

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This documentation is reserved to the professional corps. The information contained herein is based on our knowledge at the moment of going to press. The user is advised to ensure the suitability and completeness of this information in relation to the specific use that is to be made of it. The information given must not be considered a guide to self-medication. Users are invited to discuss the information with Doctors, Pharmacists or an authorised Personal Physician. Facts, studies and claims are the result of bibliographic research carried out on individual plants drugs. The editorial team is not responsible for typographical or typing errors.

This phenomenon has been closely associated with a series of human pathologies such as cardiovascular disease, diabetes, cancer and neuro-degenerative diseases [Halliwell and Cross (1994); Bray (1999); Forsberg et al. (2001)]. The antioxidant substances restore the chemical balance of the free radicals thanks to the possibility of supplying them with the electrons they are lacking. The human organism naturally defends itself against free radicals by producing endogenous antioxidants such as the superoxide dismutase, catalase and glutathione. Beyond a certain threshold, a external supply of antioxidant is necessary The main ones are:

Plant pigments: polyphenols, bioflavonoids; • Vitamins: vitamin C, vitamin E, beta-carotene (provitamin A); • Micronutrients and enzymes: selenium, copper, zinc glutathione, coenzyme • (Q10 etc)

Curcuma, together with its active ingredient curcumin, is one of the plants most studied in recent years for its antioxidant and anti-inflammatory effects found at various levels. Curcuma is a root traditionally used in Ayurvedic medicine. A US study showed that this root stops the growth of melanoma (a skin tumour) and promotes apoptosis (the death, that is, of the cancer cells): according to a report in the magazine “Cancer Research,” a group of New Jersey researchers have also proposed the use of the herb in treating prostate cancer. Curcumin is the main active ingredient of curcuma. Curcumin has potent antioxidant and anti-inflammatory properties and has been shown to be useful in this way against problems such as arthritis, asthma and irritable bowel syndrome, and in pre-cancerous lesions in the mouth. Studies carried out on curcumin have shown its capacity to block in an extremely efficient manner the propagation of free radicals, limiting the damage to DNA, to the cellular structures and tissues.