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3/30 Warm Up
1. Where in the respiratory system does gas exchange take place?
2. What is Pulmonary Ventilation?
3. What are the 4 “events of respiration”?
Respiratory Physiology II
Ch. 13c
Events of Respiration
• Pulmonary Ventilation
• External Respiration
• Respiratory Gas Transport
• Internal Respiration
External RespirationExternal Respiration
Slide 13.32a
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Oxygen movement into the blood
The alveoli always has more oxygen than the blood
Oxygen moves by diffusion towards the area of lower concentration
Pulmonary capillary blood gains oxygen
External RespirationExternal Respiration
Slide 13.32b
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Carbon dioxide movement out of the blood
Blood returning from tissues has higher concentrations of carbon dioxide than air in the alveoli
Carbon Dioxide diffuses out of pulmonary capillary blood in to the alveoli to be released from the lungs
Blood leaving the lungs is oxygen-rich and carbon dioxide-poor
Gas Transport in the BloodGas Transport in the Blood
Slide 13.33a
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Oxygen transport in the blood
Inside red blood cells attached to hemoglobin (oxyhemoglobin [HbO2])
A small amount is carried dissolved in the plasma
Gas Transport in the BloodGas Transport in the Blood
Slide 13.33b
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Carbon dioxide transport in the blood
Most is transported in the plasma as bicarbonate ion (HCO3
–)
A small amount is carried inside red blood cells on hemoglobin, but at different binding sites than those of oxygen
Internal RespirationInternal Respiration
Slide 13.34a
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Exchange of gases between blood and body cells
An opposite exchange to what occurs in the lungs
Carbon dioxide diffuses out of tissue to blood
Oxygen diffuses from blood into tissue
Internal RespirationInternal Respiration
Slide 13.34b
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Figure 13.11
External Respiration, External Respiration, Gas Transport, and Gas Transport, and Internal Respiration Internal Respiration SummarySummary
Slide 13.35
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Figure 13.10
Quick Quiz• What is occurring during External
Respiration?– Describe where Oxygen and Carbon Dioxide are
coming from and going to
• What is occurring during Internal Respiration?– Describe where Oxygen and Carbon Dioxide are
coming from and going to
Neural Regulation of RespirationNeural Regulation of Respiration
Slide 13.36
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Activity of respiratory muscles is transmitted to the brain by the phrenic and intercostal nerves
Neural centers that control rate and depth are located in the medulla
The pons appears to smooth out respiratory rate
Normal respiratory rate (eupnea) is 12–15 respirations per minute
Hypernia is increased respiratory rate often due to extra oxygen needs
Neural Regulation of RespirationNeural Regulation of Respiration
Slide 13.37
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Figure 13.12
Respiratory Rate & Depth
• What do you think will happen to your rate and depth of respiration in each of the following situations– Increased Carbon Dioxide in the blood– Decreased Oxygen in the blood
Factors Influencing Respiratory Factors Influencing Respiratory Rate and DepthRate and Depth
Slide 13.38
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Physical factors Increased body temperature
Exercise
Talking
Coughing
Volition (conscious control)
Emotional factors
Factors Influencing Respiratory Factors Influencing Respiratory Rate and DepthRate and Depth
Slide 13.39a
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Chemical factors
Carbon dioxide levels
Level of carbon dioxide in the blood is the main regulatory chemical for respiration
Increased carbon dioxide increases respiration
Changes in carbon dioxide act directly on the medulla oblongata
Factors Influencing Respiratory Factors Influencing Respiratory Rate and DepthRate and Depth
Slide 13.39b
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Chemical factors (continued)
Oxygen levels
Changes in oxygen concentration in the blood are detected by chemoreceptors in the aorta and carotid artery
Information is sent to the medulla oblongata
Quick Quiz
• What is the most important chemical influencing respiratory rate and depth?
Aging EffectsAging Effects
Slide 13.48
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Elasticity of lungs decreases
Vital capacity decreases
Blood oxygen levels decrease
Stimulating effects of carbon dioxide decreases
More risks of respiratory tract infection
Respiratory Disorders
• Worksheet
• Lung Cancer Article & Crossword