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Standard OperatingStandard Operating

ProceduresProcedures

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To understand: The purpose of having SOPs and how they aect

the daily workings of laboratories.

To discuss:

What is an SOP

Purpose of SOP

o!ponents of SOP "denti#cation process of SOP

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SOPs are written instructions thatdocument a routine or repetitive

activity followed by an organization. They addresses all requirements to

perform laboratory procedures safely.

SOPs will fail if they are not followed,therefore, the use of SOPs needs to bereviewed and reenforced bymanagement.

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SOPs detail the regularly recurring wor! processesthat are to be conducted or followed within anorganization.

They document the way activities are to be performedto maintain consistency with technical operations and

to support data quality. They describe the analytical processes, and processes

for maintaining, calibrating, and using equipment.

SOPs maintain quality control and quality assuranceprocesses and ensure compliance with governmentalregulations.

SOPs are usually speci"c to the organization or facility

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SOPs !ust address: Process #denti"cation

$ontrols %quipment $hec!s

Potentially &azardous Situations

'aste (anagement

)ny *equirements for Obtaining)uthorization

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The chemicals, process or equipmentinvolved are identi"ed. #ncluding+

The stoc! chemicals The chemicals produced in the process

The intermediates

The "nal compounds and wastes involved

and also such factors as use of catalysts,inert compounds, heat, cold, and variedoperating pressures which are involved inthe process.

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This section lists required methods tocontrol potential eposures.

Three types of controls %ngineering controls

)dministrative controls

Personal protective equipment -PP%

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%ngineering controls involve speci"cinformation on the environmentsinvolved in the procedure to maintainsafety.

%ngineering controls state+ 'or! environment -ventilated area, fume

hood, et. Storage of toic materials

*estricting access to the area protect fromhazards or potentially eplosive situations.

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#nvolve maintaining standards andmandatory laboratory practices

including+ substituting preformulated liquids instead ofpowders to be weighed and prepared

hygiene practices such as hand washing

procedures for removal and disposal ofcontaminated PP%

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This section covers information on thetypes of PP% to use such as gloves, labcoats, etc. The type of PP% must bespeci"ed, such as the type of glove.

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The %quipment chec!s sectiondescribes ways to verify thatequipment is operating correctly priorto using hazardous chemicals.

The &azardous situations sectionprovides guidance for handling spills

and identifying if a spill is causing ahazardous situation. This also providesguidance when purchasing a chemical,as to the maimum size of container.

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'aste management section identi"es safedisposal methods for routinely generatedwastes, including waste treatment ways to

ma!e handling safer. Particularly hazardous substances sectionprovides additional details if hazardoussubstances are used. /etails should address+ using speci"c containment device-fume hoods or

glove boes authorizations for using the particularly hazardous

substances describing additional procedures for

decontamination and safely handling contaminatedwaste materials

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#nclude requirements for obtainingauthorization before being allowed to

perform the procedure, operation oractivity.

This section may include+

special training prior to using

equipment0chemicals

completing a medical eamination beforeusing certain equipment

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1se clear, simple, direct wording in shortsentences

'rite procedures as chronologicalsequences

1se 2shall or 2must for mandatoryactions and 2should for advisory actions

Procedures should re3ect current practice #f any section is not applicable to the

procedure, include 450)6 under theheading 7/O 5OT leave blan!s.

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*eferences*eferences

http+00en.wi!ipedia.org0wi!i0Standard8o

perating8procedure www.microbial.uninelb.edu

http+00engineering.tamu.edu

www.epa.gov www.ehs.washington.edu