2 I NSS - Paincage · 09:00-09:45 Lecture 2 How we see and hear stuff: visual and auditory routes to understanding the material properties of objects Goodale Melvyn A. (London - Canada)

XVI CONGRESS of the Italian Society for Neuroscience2

Local Organizing Committee

ChairMicaela Morelli

Members

Cristina Cadoni Anna Carta

Marco Diana Liana Fattore Miriam Melis

Annalisa Pinna Nicola Simola

Valentina Valentini

Scientific Committee

Flavio MoroniFiorenzo Conti

Enrico CherubiniRenato Bernardini

Fabio BlandiniAndrea De Bartolomeis

Yuri BozziPaolo Francesco Fabene

Liana FattoreMaria Concetta Morrone

Felicita PedataPatrizia Popoli

Antonella Scorziello

Cagliari October 8 -11 •2015 3

PATRONAGE & SPONSOR

EXHIBITORS

4

SCIENTIFICPROGRAM

Thursday 8 October 2015

16:30-17:50 Symposium 1 THE DRUNKEN SYNAPSE: FROM MOLECULAR AND

FUNCTIONAL ADAPTATIONS TO CLINICAL PRACTICE Chairs: Biggio Giovanni (Cagliari), Romualdi Patrizia (Bologna)

Neuroadaptive mechanisms in ethanol withdrawal: from spines to spikes Diana Marco (Sassari) GABA Mechanisms in alcohol-induced effects and neuroplasticity Korpi Esa R. (Helsinki - Finland) Increased alcohol consumption and synaptic plasticity in mouse models of early-life stress Sanna Enrico (Cagliari)Role of the opioid system in alcohol addiction: recent evidence Romualdi Patrizia (Bologna) GABAergic medication in the treatment of alcohol use disorders: role of sodium oxybate and baclofen Addolorato Giovanni (Roma)

Symposium 2 NEURAL ENCODING FOR AVERSION, STRESS AND

NEGATIVE STATES: ADVANCES IN NEUROPHYSIOLOGY AND NEUROPHARMACOLOGY

Chairs: De Montis Maria Graziella (Siena), Pistis Marco (Cagliari)

PPAR-ALPHA: a potential new therapeutic target for mood disorders De Montis Maria Graziella (Siena) Cellular mechanisms in the lateral habenula coding aversive states Mameli Manuel (Paris - France) The neural circuit for aversion in cannabinoid withdrawal Muntoni Anna Lisa (Cagliari)Early life stress and risk for psychopathology: a role for epigenetics Riva Marco Andrea (Milano)



Thursday 8 October 2015

Symposium 3 PARKINSON’S DISEASE: A SPREADING PATHOLOGY?Chairs: Spano PierFranco (Brescia), Spillantini Maria Grazia (Cambridge - UK)

Prion-like properties of c-terminally truncated alpha-synucleinBellucci Arianna (Brescia) Lysines, Achilles’ heel in alpha-synuclein conversion to a neuronal oligomeric endotoxin Bubacco Luigi (Padova) Putting a brake on aging to counteract Parkinson’s disease Decressac Mickael (Pozzuoli)C-rel deficient mice, a mouse model of “spreading” PD-like pathology Parrella Edoardo (Brescia)Truncated human alpha-synuclein expression results in synaptic dysfunction and dopaminergic cell death Spillantini Maria Grazia (Cambridge - UK)

18:00-19:00 Opening of the Congress

Lecture 1

Huntington: the story of an ancient gene in search of a better futureCattaneo Elena (Milano)

Host: Conti Fiorenzo

19:00-20:30 Welcome Cocktail


09:00-09:45 Lecture 2

How we see and hear stuff: visual and auditory routes to understanding the material properties of objects Goodale Melvyn A. (London - Canada)

Host: Morrone Concetta

10:00-11:20 Symposium 4 INNOVATIVE STRATEGIES FOR RESCUING TISSUE INJURY INDUCED BY STROKE (UNDER 40) Chairs: Carulli Daniela (Torino), Pignataro Giuseppe (Napoli)

Drug repurposing for immune modulation in ischemic stroke Amantea Diana (Cosenza)Role of trail in focal ischemia Di Benedetto Giulia (Catania) Epigenetic drugs to reduce post ischemic brain injury, a new therapeutic approach targeting acetylation of NF-kappaB and histones Lanzillotta Annamaria (Brescia) Ionic homeostasis and endogenous neuroprotection Pignataro Giuseppe (Napoli)

Symposium 5 EARLY IN LIFE DRUG EXPOSURE: FUNCTIONAL CONSEQUENCES ON BRAIN DEVELOPMENTChairs: Frau Roberto (Cagliari), Rubino Tiziana (Busto Arsizio)

Shank3 insufficiency uncovers a role of VTA in ASDs Bellone Camilla (Lausanne - Switzerland)Short-term abstinence from developmental exposure to cocaine alters the glutamate synapse following acute stress: implication of glucocorticoid receptor Fumagalli Fabio (Milano) Prenatal exposure to cannabinoids affects postnatal synaptic properties and plasticity of excitatory transmission on dopamine neurons of the ventral tegmental area Melis Miriam (Cagliari) The impact of adolescent cannabinoid exposure on brain maturation: focus on epigenetic mechanisms Rubino Tiziana (Busto Arsizio)

Friday 9 October 2015


Symposium 6 ROLE OF GLIAL CELLS IN THE CENTRAL MECHANISM OF CHRONIC PAINFP7 (N. 603191- PAINCAGE PROJECT) SPONSORED SYMPOSIUM Chairs: Marinelli Silvia (Roma), Nykjaer Anders (Aarhus - Denmark)

NGF and glial cells: an overlooked story Capsoni Simona (Pisa) TRPV1 channels in the brain: modulation of microglia to neuron communication in naive and neuropathic mice Marinelli Silvia (Roma)

Sortilin – A new target for treatment of neuropathic pain? Nykjaer Anders (Aarhus - Denmark)

Free oral communications session 1SENSORY SYSTEMS AND SENSORIMOTOR PROCESSING Chairs: Caleo Matteo (Pisa), Poggi Lucia (Heidelberg - Germany)

Short-term monocular deprivation alters GABA in the adult human visual cortex Lunghi Claudia (Pisa) Light-induced neurodegeneration, an innovative approach to model Parkinson’s disease Maggio Roberto (L’Aquila) PS-1 protein and free L-Arg enhance the PROP bitter taste responsiveness by acting as “salivary carriers”Melis Melania (Cagliari)A polymeric neural-interface restores light sensitivity and visual acuity in adult blind Royal College of Surgeons ratsMaya-Vetencourt José Fernando (Genova)Repeated 6-Hz Corneal Stimulation Progressively Increases FosB/ΔFosB Levels in the Lateral Amygdala and Induces Seizure Generalization to the HippocampusGiordano Carmela (Modena)


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11:20-11:40 Break

11:40-13:00 Symposium 7 BOOSTING CELL REPAIR IN NEURODEGENERATIVE

DISEASES: MOLECULAR AND CELLULAR MECHANISMS AND TARGETING STRATEGIES Chairs: Marchetti Bianca (Catania), Harvey Kirsten (London - UK)

Implications of familial mutations for the pathogenesis and treatment of neurodegenerative diseases Harvey Kirsten (London - UK)

Stem cell-based modulation of innate and adaptive immune responses in CNS plasticity upon injuries Peruzzotti Luca (Cambridge - UK)

Neuroinflammatory cytokines and their receptors as innovative targets: restraint of neuronal damage and restoration of function in AD Cantarella Giuseppina (Catania)Targeting Wnt signaling for dopaminergic (DA) neurorepair in PD: tripartite dialogue between DA neuroprogenitors, glial cells and the injured DA neurons Marchetti Bianca (Catania/Troina)

Symposium 8 PHYSIOLOGY AND PHYSIOPATHOLOGY OF

BDNF: TOWARDS THE DEVELOPMENT OF NEW THERAPEUTIC STRATEGIES FOR MAJOR NEURO-PSYCHIATRIC DISEASES

Chairs: Baj Gabriele (Trieste), Popoli Maurizio (Milano)

The “spatial and quantitative code” of BDNF variants: a therapeutic target for the disorders of the nervous system Baj Gabriele (Trieste) Silencing BDNF expression with herpes simplex virus type-1 based amplicon vectors in an experimental model of temporal lobe epilepsy Falcicchia Chiara (Ferrara) Arc expression is modulated post-transcriptionally by splicing of its 3’utr and BDNF signalling Giorgi Corinna (Roma)


Environment-induced neuroplasticity changes in knock-in mice with the human BDNF val66met polymorphism Ieraci Alessandro (Milano) Essential role of astroglial p75 ntr for LTP maintenance and visual recognition memory Vignoli Beatrice (Roma)

Symposium 9 CHANGES IN NEUROACTIVE STEROID LEVELS MAY

INDUCE BENEFICIAL AND DETRIMENTAL EFFECTS IN THE NERVOUS SYSTEM

Chairs: Melcangi Roberto Cosimo (Milano), Riva Marco Andrea (Milano)

Targeting neurosteroid pathways for the treatment of Tourette syndrome and impulse control disorders: from bench to bedside Bortolato Marco (Lawrence - USA)Neonatal neuroactive steroid levels alteration: long term-effects on behaviour in rats Darbra Sonia (Barcelona - Spain)Effect of finasteride treatment in the nervous system: clinical and experimental observationsMelcangi Roberto Cosimo (Milano)Neurosteroids during development: implications for GABA-A receptor function and stress sensitivity in adulthood Porcu Patrizia (Cagliari)

Free oral communications session 2NEURODEGENERATIVE DISEASES Chairs: Simola Nicola (Cagliari), Spillantini Maria Grazia (Cambridge - UK)

Drug development strategy for neurodegenerative diseasesMandel Silvia (Netanya - Israel) RNA-therapeutics of gene haploinsufficiences Fimiani Cristina (Trieste) A longitudinal diffusion kurtosis imaging in transgenic mouse model of Parkinson’s disease overexpressing alpha synucleinKhairnar Amit (Brno - Czech Republic)Silencing of upregulated KV3.4 potassium channels reduces astrocytes activation, SS-amyloid level in Tg2576 miceCiccone Roselia (Napoli)




Ambroxol-induced rescue of defective glucocerebrosidase is associated with increased LIMP-2 and saposin C levels in GBA1 mutant Parkinson’s disease cellsAmbrosi Giulia (Pavia)

13:00-14:00 Lunch

14:00-16:00 Poster Session 1

16:00-16:45 Lecture 3 Dopamine and synaptic plasticity: from motor to

cognitive dysfunctions Calabresi Paolo (Perugia)

Host: Blandini Fabio

17:00-18:20 Symposium 10

INTRINSIC AND EXTRINSIC REGULATION OF OLIGODENDROCYTE PROGENITOR CELL SELF-RENEWAL AND DIFFERENTIATION

Chairs: Angulo Maria Cecilia (Paris - France), Boda Enrica (Torino)

Regulation of synaptic connectivity between GABAergic interneurons and NG2 cells during cortical oligodendrogenesis Angulo Maria Cecila (Paris - France) Molecular mechanisms in oligodendroglioma infiltration and malignancy Appolloni Irene (Genova) Balancing self-renewal and differentiation of the oligodendrocyte progenitor pool: insights into cell intrinsic regulatory mechanisms Boda Enrica (Torino)New mechanisms regulating oligodendroglial differentiation: focus on the GPR17 receptor and related microRNAs Lecca Davide (Milano)


Symposium 11 RECENT ADVANCES IN THE UNDERSTANDING OF

L-DOPA-INDUCED DYSKINESIA: FOCUS ON SEROTONIN, GLUTAMATE AND DOPAMINERGIC TRANSMISSIONS IN ANIMAL MODELS OF PARKINSON’S DISEASE

Chairs: Carta Manolo (Cagliari), Tonini Raffaella (Genova)

The serotonin system in L-DOPA induced dyskinesia, from rats to humans Björklund Anders (Lund - Sweden)Alteration of NMDA receptor subunits as synaptic trait of L-DOPA-induced dyskinesia: molecular mechanisms and effect of eltoprazine treatment Gardoni Fabrizio (Milano) Behavioural and electrophysiological characterization of serotonergic 5-HT1A/1B agonist, eltoprazine, in experimental L-DOPA-induced dyskinesia Picconi Barbara (Roma)mTOR signaling in L-DOPA-induced dyskinesia Usiello Alessandro (Napoli)

Symposium 12 THE COMPLEXITY OF MOTOR NEURON DISEASES Chairs: Poletti Angelo (Milano), Bonanno Giambattista (Genova)

Motor neuron-immune system cross-talk in ALS: evidence and consequences on the disease Bendotti Caterina (Milano)Group I metabotropic glutamate receptors and neurotoxicity in amyotrophic lateral sclerosis Milanese Marco (Genova) The involvement of muscle in SBMA and ALS Pennuto Maria (Trento) The protein quality control system in motoneuron diseases Rusmini Paola (Milano)




Free oral communications session 3

NEW INSIGHTS ON SYNAPTIC PLASTICITY AND NEURAL CONNECTIVITY Chairs: Bozzi Yury (Pisa), Scorziello Antonella (Napoli)

DOI modulates striatal plasticity by inducing ERK phosphorylation in striatum through 5-HT2A/C receptors in prefrontal cortexEspinoza Stefano (Genova)Diurnal oscillation of synaptic wiring of orexinergic neurons in miceLaperchia Claudia (Verona)Quantitative analysis of the co-distribution of GLT-1 and Na+, K+-ATPase alpha isoforms in rat cerebral cortexMelone Marcello (Ancona)A molecular code of neural connectivity in the piriform cortexDiodato Assunta (Paris - France)Ethanol-induced loss of dendritic spines in accumbens medium spiny neurons. Insights and hints from a computational modelEnrico Paolo (Sassari)

18:20-20:00 Posters session 2 & Wine and cheese

20:00 General Member Assembly


Saturday 10 October 2015

09:00-09:45 Lecture 4 Brain connectomics: exploring the connectome and

synaptome De Felipe Javier (Madrid - Spain)

Host: Fabene Paolo

10:00-11:20 Symposium 13 NEUROTROPHINS IN PHYSIOLOGY AND PATHOLOGY:

NOVEL MOLECULAR AND CELLULAR PERSPECTIVES (UNDER 40)

Chairs: Cesca Fabrizia (Genova), Ieraci Alessandro (Milano)

Kidins220/ARMS is a functional mediator of neurotrophin signaling pathways in nervous system development, maturation and plasticity Cesca Fabrizia (Genova) Neurotrophic-priming of glucocorticoid actions Jeanneteau Freddy (Montpellier - France) Single molecule imaging and tracking of neurotrophins and their receptors in living neuronal cells Marchetti Laura (Pisa) BICD1 and dynein modulate long-range growth factor signalling Terenzio Marco (Rehovot - Israel)

Symposium 14 PARKINSON’S DISEASE: FROM NEUROPATHOLOGY TO

PHARMACOLOGICAL AND NON PHARMACOLOGICAL TREATMENT OF MOTOR COMPLICATIONS

Chairs: Brambilla Riccardo (Milano), Picconi Barbara (Roma)

Dyskinesia and neuroinflammation: evidence from pulsatile versus continuous L-DOPA delivery Carta Anna R. (Cagliari) Approaches to the treatment of L-DOPA induced dyskinesia based on ras-erk targeting: far from being a simple matterFasano Stefania (Milano)


Dopamine D3 receptor modulates L-DOPA-induced dyskinesia bytargeting D1 receptor-mediated striatal signalingMoratalla Rosario (Madrid - Spain) Loss of coordinated regulation of synaptic plasticity at striatal projection neurons in the pathophysiology of motor control. Tonini Raffaella (Genova) Intensive rehabilitation in the treatment of L-DOPA-induced dyskinesia Frazzitta Giuseppe (Gravedona ed Uniti)

Symposium 15 EATING DISORDERS: FROM BENCH TO BEDSIDE AND

RETURN – ISN SPONSORED SYMPOSIUM Chairs: Passani Beatrice (Firenze), Gaetani Silvana (Roma)

The BclI receptor gene polymorphism (rs41423247) moderates the association between childhood overweight, psychopathology, and clinical outcomes in eating disorders patients: a 7 years follow up studyRicca Valdo (Firenze) First evidence for a role of oleoylethanolamide in the regulation of appetite in humans Leweke Markus (Mannheim - Germany) Animal models of eating disorders and obesity or food addiction Lutz Thomas (Zurigo - Switzerland) Role of oleoylethanolamide in the “gut-to-brain axis”: possible implications for the treatment of obesity and eating disordersRomano Adele (Roma) Role of the central histaminergic system in the hypophagic, procognitive and antidepressant-like effects of the endogenous PPAR-ALPHA ligand oleoylethanolamide Provensi Gustavo (Firenze)





COGNITION AND DEPRESSIVE-LIKE SYMPTOMS: THE ROLE OF EXPERIENCE, NEUROTRANSMITTERS AND DRUGS Chairs: Fattore Liana (Cagliari), Korpi Esa R. (Helsinki - Finland)

Drugs of abuse change norepinephrine transmission in the bed nucleus of stria terminalis (BNST): a microdialysis study in freely moving rats Jadzic Dragana (Serbia/Cagliari)

Noradrenergic regulation of spatial learning and memory in the rat: effects of selective lesions and repair by transplanted noradrenergic neuroblastsLeanza Giampiero (Trieste)

Esculetin attenuates lipopolysaccharide-induced depressive-like behavior in mice: inhibition of pro-inflammatory cytokines, and up-regulation of BDNF levelSulakhiya Kunjbihari (Guwahati, India)

The outcome of antidepressant treatment on molecular, cellular and behavioural endophenotypes of depression is affected by the quality of the living environment Poggini Silvia (Roma)

Behavioral characterization of dehydroepiandrosterone effects in ratsSamardzic Janko (Belgrade - Serbia)

11:20-11:40 Break

11:40-13:00 Symposium 16 NOSE AND GUT: OPEN DOORS TO THE BRAIN Chairs: Bentivoglio Marina (Verona), Zurzolo Chiara (Paris - France)

Gut microbiota and brain: a mutual relationship Fiorucci Stefano (Perugia) The nasal cavity as railway of pathogens and toxins to the brain Kristensson Krister (Stockholm - Sweden)


The enteric nervous system and the progression of Parkinson’s disease: facts and perspectives Pizzi Marina (Brescia)The olfactory mucosa in the diagnosis of prion and prion-like neurodegenerative diseases: facts and perspectives Zanusso Gianluigi (Verona)

Symposium 17 D-AMINO ACIDS, FROM BRAIN PHYSIOLOGY TO

DISORDERS Chairs: Sacchi Silvia (Varese), Usiello Alessandro (Napoli)

Critical role of D-serine in synaptic plasticity relevant to cocaine addiction D’Ascenzo Marcello (Roma)D-aspartate-based modulation of NMDA receptor neurotransmission: preclinical implication Errico Francesco (Napoli)Of the importance of space and time in the functions of the NMDA receptor coagonists in the hippocampus Mothet Jean Pierre (Marseille - France) D-serine metabolism in the brain: the role of d-amino acid oxidase Sacchi Silvia (Varese)

Symposium 18 HDAC INHIBITION IN NEUROPROTECTION: NEW

CHANCE FOR THERAPY Chair: Formisano Luigi (Napoli)

Dynamic epigenetic regulation of NCX1 expression in brain ischemia and in ischemic brain preconditioning, by modification of histone acetylationFormisano Luigi (Napoli) Role of PARP and HDACS in hippocampal slice models of ischemic preconditioning in vitro Pellegrini-Giampietro Domenico E. (Firenze)



HDAC class I inhibitors and their effect in an in vivo model of Huntington’s diseaseBasso Manuela (Trento)Epigenetic and transcriptional dysfunction in ischemic brain injury and Huntington’s disease: from mechanisms to therapeutic candidatesYildirim Ferah (Berlin - Germany)


BRAIN INJURY, NEUROINFLAMMATION AND PAIN Chairs: De Simoni Maria Grazia (Milano), Annunziato Lucio (Napoli)

Neurite contact guidance of ubiquitin ligase E3A (UBE3A)-KO neurons by nano-grooved substrates Tonazzini Ilaria (Milano) Alginate-based hydrogels for central nervous system tissue regenerationCasarosa Simona (Trento)Genetic ablation of Homeodomain Interacting Protein Kinase (HIPK2) selectively induces apoptosis of cerebellar Purkinje cells and generates an ataxic-like phenotype Anzilotti Serenella (Napoli) Microglial microvesicles as therapeutic vector for neuroinflammationCasella Giacomo (Milano)Non-paralytic botulinum molecules for the control of painMangione Antonina Stefania (London - UK)

13:00-14:00 Lunch




14:00-16:00 Poster Session 3

16:00-16:45 Lecture 5

Immune proteins in brain development and synaptic plasticity

Matteoli Michela (Milano)

Host: Cherubini Enrico

17:00-18:20 Symposium 19 INNOVATIVE STRATEGIES TO FOSTER BRAIN REPAIR

AFTER DAMAGE Chairs: Caleo Matteo (Pisa), De Simoni Maria Grazia (Milano)

Role of perineuronal nets in CNS plasticity and repair Carulli Daniela (Torino) Ischemic and pharmacological pre-conditioning and post-conditoning: molecular mechanisms of neuroprotection and neuroplasticity Gerace Elisabetta (Firenze)Robotic rehabilitation and plasticizing treatments for the recovery of motor function after focal cortical stroke Lai Stefano (Pisa) Mesenchymal stromal cell therapy to foster endogenous reparative mechanisms in the acute injured brain Zanier Elisa R. (Milano)


Symposium 20 EMERGING ROLE OF EXTRACELLULAR VESICLES IN THE BRAIN:

IMPLICATIONS FOR INTERCELLULAR COMMUNICATIONS, BIOMARKER DEVELOPMENT AND THERAPY

Chairs: Verderio Claudia (Milano), Benussi Luisa (Brescia)

Role of exosomes released by astrocytes overexpressing mutant SOD1 in disease spreading and motor neuron pathology in amyotrophic lateral sclerosis Basso Manuela (Trento) Extracellular vesicles isolated from bone marrow mesenchymal stem cells display an anti-inflammatory effect in experimental models of Alzheimer’s disease Coco Silvia (Milano)Diagnostic role of EVs in neurodegenerative and neuroinflammatory diseases Furlan Roberto (Milano) Shuttling of micrornas from glia-to-neurons: modulation of neuronal gene expression Prada Ilaria (Milano)

Symposium 21 MECHANISMS OF EMBRYONIC AND ADULT

NEUROGENESIS - GEI (GRUPPO EMBRIOLOGICO ITALIANO) SPONSORED SYMPOSIUM

Chairs: Tata Ada Maria (Roma), Casarosa Simona (Trento)

Role for PPAR transcription factors in the energetic metabolic switch occurring during neurogenesis Cimini Anna Maria (L’Aquila) COUP-TFI functions in adult neurogenesis De Marchis Silvia (Torino) Altered serotonin homeostasis affects development and maintenance of serotonergic neuronal circuitry Pasqualetti Massimo (Pisa)




Ascidians as a simple model for the study of development and evolution of vertebrate nervous system Pennati Roberta (Milano)Orchestrating cell fate decisions in progenitor cells of the embryonic retinaPoggi Lucia (Heidelberg - Germany)


ASTROGENESIS, NEURAL CONNECTIVITY AND TOXICITY Chairs: Fabene Paolo (Verona), Angulo Maria Cecilia (Paris - France)

EMX2 role in corticocerebral astrogenesis and glioblastoma tumorsFalcone Carmen (Trieste)The cross-talk within Theta rhythms between secondary auditory cortex and basolateral amygdala is essential during remote fear memory recallCambiaghi Marco (Torino)In vitro glutamate treatments modify AMPA RNA editing and ADARs activityFilippini Alice (Brescia)Deletion of LRRK2 protects mice from early cognitive impairments induced by alpha-synuclein fibril inoculationVolta Mattia (Bolzano)Long-lasting effects of adolescent MDMA and caffeine exposure on mesolimbic dopamine transmission, cognitive functions and dopaminergic neurotoxicity in ratsCadoni Cristina (Cagliari)

18:20-20:00 Posters session 4 & Wine and cheese

21:00 Congress dinner at Convento San Giuseppe in Cagliari (reservation is requested)


Sunday 11 October 2015

09:00-09:45 Lecture 6

Dopamine and reward: the never ending story Di Chiara Gaetano (Cagliari)

Host: Moroni Flavio

10:00-11:20 Symposium 22 DOPAMINE FUNCTIONS IN NEURODEGENERATION

AND PLASTICITY (UNDER 40) Chairs: Espinoza Stefano (Genova), Ronzitti Giuseppe (Evry - France)

Role of nicotinic and dopamine D3 receptor crosstalk in the regulation of dopaminergic neurons plasticity Bontempi Leonardo (Brescia) Identification and characterization of new regulators of the dopamine system in the animal model C. Elegans Di Schiavi Elia (Napoli) Pronounced dopaminergic dysregulation in dopamine transporter knockout rats Leo Damiana (Genova)HDAC inhibition reduces dopamine-dependent neurodegeneration in a mouse model of DAT-deficiency syndrome Ronzitti Giuseppe (Evry - France)

Symposium 23 NEW TARGETS, TRANSCRIPTIONAL AND

TRANSDUCTIONAL FACTORS AS AN INNOVATIVE STROKE RESCUING STRATEGY

Chair: Annunziato Lucio (Napoli)

Remyelination in stroke: new targets and new challenges to implement repair and functional recovery Abbracchio Maria Pia (Milano)Targeting transcriptional and transductional mechanisms controlling Na+/Ca2+ Exchanger (NCX) as new strategy in stroke intervention Annunziato Lucio (Napoli)



Versatility of the complement system in stroke De Simoni Maria Grazia (Milano)Carbonic anhydrase IX and its interactome in hypoxiaZambrano Nicola (Napoli)

Symposium 24 HCN CHANNELS IN THE PHYSIOLOGY AND PATHOLOGY OF THE NERVOUS SYSTEM

Chairs: Di Francesco Jacopo C. (Milano), Mannaioni Guido (Firenze)

HCN ion channels and painMcNaughton Peter (London - UK)Hyperpolarization-activated cyclic nucleotide gated channels as a promising new target for pain treatmentResta Francesco (Firenze)Contribution of the h-current to autorhythmic activity in dopaminergic neurons of substantia nigra and olfactory bulbPignatelli Angela (Ferrara)Dysfunctional HCN ion channels in idiopathic epilepsyDi Francesco Jacopo C. (Milano) The hyperpolarization-activated current as a determinant of selective nigrostriatal degeneration in Parkinson’s desease Masi Alessio (Firenze)


INVOLVEMENT OF NEURODEGENERATIVE PROCESSES IN NEUROLOGICAL DISEASES

Chairs: Morelli Micaela (Cagliari), Bernardini Renato (Catania)

Effect of curcumins in RNA regulation and in amyloid beta aggregation in Alzheimer’s disease patients.Gagliardi Stella (Pavia)Identification of 3microRNAs of potentially regulating the expression of GPR17, a receptor involved in the development of oligodendroglial precursor cells Marangon Davide (Milano)


Exosomes from mesenchymal stem cells: experimental assessment on in vitro and in vivo models of ALSBonafede Roberta (Verona) Saffron treatment in rat model of retinal dystrophy Di Paolo Mattia (L’Aquila) Intracarotid infusion of mesenchymal stem cells in an animal model of Parkinson’s disease, focusing on cell distribution, neuroprotective and behavioral effectsCerri Silvia (Pavia)

11:20-11:40 Break

11:40-13:00 Symposium 25 EPIGENETIC MECHANISM IN BRAIN DISORDERS

Chairs: Battaglioli Elena (Milano), Pizzorusso Tommaso (Firenze)

Strategies to enhance the cell response to proteotoxicity in amyotrophic lateral sclerosis (ALS)

Crippa Valeria (Pavia) Expression and dendritic trafficking of BDNF-6 splice variant

are impaired in knock-in mice carrying human BDNF val66met polymorphism Mallei Alessandra (Milano)Experience-dependent DNA methylation regulates plasticity in the developing visual cortex Pizzorusso Tommaso (Firenze)LSD1/KDM1A modulates stress-evoked transcription of immediate early genes and emotional behavior Rusconi Francesco (Milano)



Symposium 26 PRION AND PRION-LIKE MEACHANIMS IN NEURODEGENERATIVE DISORDERS. A MOLECULAR AND CELLULAR VIEW ON NEURODEGENERATION

Chairs: Legname Giuseppe (Trieste), Zanusso Gianluigi (Verona)

Importance of TDP-43 N-terminal region in aggregationBuratti Emanuele (Trieste)Alpha-synuclein amyloid interaction with prion protein: a putative overlap of two neurodegenerative diseasesLegname Giuseppe (Trieste) Unraveling the molecular basis of phnotypic heterogeneity of Alzheimer disease: the model of prion strains Di Fede Giuseppe (Milano) Role of tunneling nanotubes (TNTS) in intercellular spreading of prions and other protein assemblies involved in neurodegenerative diseasesZurzolo Chiara (Parigi - France)

Symposium 27 ACETYLCHOLINE IN THE BASAL GANGLIA Chairs: Mercuri Nicola Biagio (Roma), Fratta Walter (Cagliari)

Abused drugs regulate dopamine da release in the striatum throughout presynaptic nicotinic receptors Mercuri Nicola Biagio (Roma)

Role of muscarinic M1 receptors in DYT1 dystonia Pisani Antonio (Roma) The functional cross-talk between nicotinic and glutamatergic

receptors on dopaminergic nerve terminls in the rat nucleus accumbens Pittaluga Anna (Genova)G protein-coupled receptors oligomers in the basal ganglia: from single-molecule fluorescence microscopy to therapeutic perspectives Scarselli Marco (Pisa)

13:00 Closing remarks




13:30-14:30 Sandwich lunch

14:30-17:00 WORKSHOP on “Professional skills” for under 40 Led by Marina Bentivoglio (University of Verona) and Marina Pizzi (University of Brescia)

POSTERS


POSTER SESSION 1 e 2 DEVELOPMENT 1/09 - NF-KAPPAB P50 KNOCK-OUT MICE AS ANIMAL MODEL OF

NEURODEVELOPMENTAL DISORDERS Sara Anna Bonini Andrea Mastinu, Giuseppina Maccarinelli, Marika Premoli, Giulia Ferrari-Toninelli, Maurizio Memo

2/09 - FROM NGF SIGNALING TO MIR-219-5P: OLIGODENDROCYTES’ DIFFERENTIATION AND MYELINATION Sabrina Turturro Rossella Brandi, Ivan Arisi, Raffaella Scardigli, Corinna Giorgi, Andrea Ennio Storti, Flavia Ricevuti, Federico La Regina, Mara D’Onofrio, Antonino Cattaneo

3/09 - MULTIGENERATIONAL EFFECTS OF PRENATAL EXPOSURE TO VALPROIC ACID ON NEURODEVELOPMENT: A PRECLINICAL STUDY Anna Maria Tartaglione Laura Ricceri, Benedetta Perrone, Alessia De Felice, Emanuela Balestrieri, Paola Sinibaldi-Vallebona, Gemma Calamandrei

4/09 - MATERNAL IMMUNE ACTIVATION AFFECTS DOPAMINE NEURON SPONTANEOUS ACTIVITY IN THE OFFSPRING Marta De Felice Sonia Aroni, Anna Lisa Muntoni, Roberto Frau, Alessandra Pardu, Paola Devoto, Marco Pistis

5/09 - REPEATED MATERNAL SEPARATION IN C57BL/6J MICE: CHANGES IN HIPPOCAMPAL GABAERGIC AND GLUERGIC SYNAPTIC FUNCTION AND INCREASED VOLUNTARY ETHANOL CONSUMPTION Ashish Avinash Gorule Giuseppe Talani, Valentina Licheri, Giovanni Biggio, Enrico Sanna

6/09 - DIFFERENTIATION AND MIGRATION OF NEURAL STEM CELLS (NSCS) DURING PRECONDITIONING IN A MOUSE MODEL OF NEONATAL HYPOXIA ISCHEMIA Paola Brancaccio Serenella Anzilotti, Pierpaolo Cerullo, Ornella Cuomo, Gianfranco Di Renzo, Lucio Annunziato, Giuseppe Pignataro

7/09 - THE CHRNA7 AND ITS DUPLICATED ISOFORM, CHRFAM7A, GENE REGULATION AND EXPRESSION IN NEURONAL AND IMMUNE CELL MODEL Annalisa Maroli Diego Fornasari, Roberta Benfante




8/09 - NURR1 AND LMX1A TRANSCRIPTION FACTORS COOPERATE TO PROMOTE DOPAMINERGIC DIFFERENTIATION Floriana Volpicelli Salvatore Pulcrano, Claudia De Sanctis, Carla Perrone Capano, Umberto di Porzio, Gian Carlo Bellenchi

9/09 - THE SEROTONIN RECEPTOR 7 STIMULATES NEURITE ELONGATION THROUGH CDK5, MTOR AND CDC42 PATHWAYS AND MODULATES DENDRITIC SPINES MORPHOLOGY Luisa Speranza Marta Molinari, Floriana Volpicelli, Maria Egle De Stefano, Loredana Lombardi, Gian Carlo Bellenchi, Umberto di Porzio, Marianna Crispino, Carla Perrone-Capano

10/09 - INVOLVEMENT OF THE NA+/CA2+ EXCHANGER ISOFORM 1 (NCX1) IN NGF-INDUCED NEURONAL DIFFERENTIATION THROUGH CA2+-DEPENDENT AKT PHOSPHORYLATION Rossana Sirabella Agnese Secondo, Alba Esposito, Francesca Boscia, Anna Pannaccione, Pasquale Molinaro, Maria Cantile, Roselia Ciccone, Maria Josè Sisalli, Antonella Scorziello, Gianfranco Di Renzo, Lucio Annunziato

11/09 - INFLAMMATORY RELATED PATHWAYS AND SGK1 SIGNALING AS TARGETS OF EARLY LIFE STRESSFUL EVENTS: ROLE OF DNA METHYLATION AND MIRNAS Giona Plazzotta Alessia Luoni, Marco Andrea Riva, Carmine Maria Pariante, Annamaria Cattaneo

12/09 - INVOLVEMENT OF MUSCLE-SPECIFIC MIRNA-206 IN THE SPINAL MUSCULAR ATROPHY PATHOGENESIS Marina Boido Valeria Valsecchi, Elena De Amicis, Antonio Piras, Alessandro Vercelli

13/09 - ORIGIN AND GENERATION OF DIFFERENT ASTROGLIAL PHENOTYPES IN THE CEREBELLUM Valentina Cerrato Elena Parmigiani, Ketty Leto, Elisa Fucà, María Figueres-Oñate, Laura López Mascaraque, Annalisa Buffo


POSTER SESSION 1 e 2 EXCITABILITY, SYNAPTIC TRANSMISSION, NETWORK FUNCTIONS 14/09 - ACTION OF MEMANTINE ON STRIATAL SYNAPTIC PLASTICITY

Maria Mancini Veronica Ghiglieri, Vincenza Bagetta, Valentina Pendolino, Anna Vannelli, Fabrizio Cacace, Desirée Mineo, Paolo Calabresi, Barbara Picconi

15/09 - A NOVEL CAMP/PKA/APP/ASS PATHWAY MODULATES HIPPOCAMPAL LTP Claudia Rebosio Daniela Rivera, Maria Adelaide Pronzato, Daniela Puzzo, Ottavio Arancio, Roberta Ricciarelli, Ernesto Fedele

16/09 - DIFFERENT MOUSE GENETIC MODELS OF HUMAN DYT1 DYSTONIA SHARE CHANGES OF PHOSPHODIESTERASE-10A IN BASAL GANGLIA CIRCUITS Ilaria Saverioni Silvia Cardarelli, Vincenza D’Angelo, Valentina Castelli, Mauro Giorgi, Stefano Biagioni, Francesca Palumbo, Alessandro Martorana, Paola Bonsi, Antonio Pisani, Giuseppe Sancesario

17/09 - IH SUPPRESSION INCREASES SYNAPTIC EXCITABILITY OF MIDBRAIN DOPAMINERGIC NEURONS IN VITRO AND CAUSES SELECTIVE NIGROSTRIATAL DEGENERATION IN VIVO Carmen Carbone Alessio Masi, Roberto Narducci, Francesco Resta, Alessia Costa, Gustavo Provensi, Guido Mannaioni

18/09 - LOCALLY SYNTHESIZED 17BETA-ESTRADIOL MEDIATES SYNAPTIC LONG-TERM POTENTIATION VIA D1-LIKE DOPAMINE SIGNALING IN THE DORSAL STRIATUM Alessandro Tozzi Antonio de Iure, Michela Tantucci, Valentina Durante, Ana Quiroga-Varela, Michela Di Mauro, Petra Mazzocchetti, Silvarosa Grassi, Vito Enrico Pettorossi, Paolo Calabresi

19/09 - FENOFIBRATE, A CLINICALLY USED PPARA AGONIST, ENHANCES DOPAMINE AND SEROTONIN NEURONAL ACTIVITY Sonia Aroni Marta De Felice, Maria Graziella De Montis, Miriam Melis, Marco Pistis



20/09 - ELEVATION OF KYNURENIC ACID LEVELS SUPPRESSES DELTA9-TETRAHYDROCANNABINOL-INDUCED EXCITATION OF MESOLIMBIC DOPAMINE AND PREFRONTAL CORTEX PYRAMIDAL NEURONS Claudia Sagheddu Miriam Melis, Anna Lisa Muntoni, Marco Pistis

21/09 - EARLY ALTERATION OF HIPPOCAMPAL NEURONAL FIRING INDUCED BY ABETA42 OLIGOMERS IN ALZHEIMER’S DISEASE Daniela Gavello Arianna Allio, Chiara Calorio, Hélène Marie, Emilio Carbone, Andrea Marcantoni

22/09 - GABAA- AND BENZODIAZEPINE RECEPTOR-MEDIATED INHIBITION OF HIPPOCAMPAL NEURONAL FIRING INDUCED BY BUD EXTRACTS FROM TILIA TOMENTOSA MOENCH Chiara Calorio Arianna Allio, Claudio Franchino, Emilio Carbone, Andrea Marcantoni

23/09 - LEVETIRACETAM DOWN-REGULATES THE EXPRESSION OF SEVERAL SYNAPTIC VESICLES PROTEINS IN RAT BRAIN CORTEX Daniele Marcotulli Giorgia Fattorini, Luca Bragina, Fiorenzo Conti

24/09 - TDP43 MODULATION BY THE GLUTAMATERGIC SYSTEM Michele Nutini Patrizia Longone

25/09 - CHOLINERGIC MODULATION OF MEDIAL SEPTUM AND HIPPOCAMPAL CA3 OUTPUTS IN VIVO Marilena Griguoli Stefano Zucca, Meryl Malezieux, Christophe Mulle

26/09 - ELECTROPHYSIOLOGICAL CHARACTERIZATION OF CALRETININ INTERNEURONES IN THE MOUSE OLFACTORY BULB Angela Pignatelli Alex Fogli Iseppe, Samah Batran, Faride Pighin, Elena Zucchini, Pietro Scaduto, Ottorino Belluzzi

27/09 - IDENTIFICATION OF DIFFERENT SPLICING VARIANTS OF KV7.4 POTASSIUM CHANNELS IN THE F11 NEURONAL CELL LINE Alessandro Medoro Maria Virginia Soldovieri, Iolanda Vinciguerra, Maurizio Taglialatela



28/09 - IMMUNOCHEMICAL DETECTION OF BDNF AND TRKB IN THE BRAIN OF PSYCHOGENETICALLY SELECTED ROMAN HIGH- AND LOW-AVOIDANCE RATS Maria Pina Serra Laura Poddighe, Marianna Boi, Maria Antonietta Piludu, Osvaldo Giorgi, Maria Giuseppa Corda, Marina Quartu

29/09 - STUDY OF THE MECHANISMS REGULATING THE LOCALIZATION OF NA+/CA2+ EXCHANGER 3 IN MITOCHONDRIA AND ITS PATHOPHYSIOLOGICAL IMPLICATIONS Stefania Fiorillo Antonella Scorziello, Pasquale Molinaro, Maria Josè Sisalli, Lucio Annunziato

30/09 - BIOCHEMICAL, MORPHOLOGICAL, AND PHARMACOLOGICAL EVIDENCE FOR KV7.4 CHANNELS EXPRESSION IN NEURONAL MITOCHONDRIA Laura Manocchio Iolanda Vinciguerra, Maria Virgina Soldovieri, Gianluca Paventi, Paolo Ambrosino, Vincenzo Calderone, Salvatore Passarella, Maurizio Taglialatela

31/09 - BEHAVIORAL AND ELECTROPHYSIOLOGICAL ASPECTS OF NEOCORTICAL CB1 SPECIFIC KO MICE REVEAL A MURINE MODEL OF NEUROPATHIC PAIN Maria Cristina Marrone Michela Giustizieri, Giovanni Marsicano, Silvia Marinelli

32/09 - ALPHA-SYNUCLEIN IMPAIRS LONG-TERM POTENTIATION OF SYNAPTIC TRANSMISSION OF STRIATAL CHOLINERGIC INTERNEURONS TARGETING THE GLUN2D-EXPRESSING NMDA RECEPTOR Antonio de Iure Alessandro Tozzi, Valentina Durante, Ana Quiroga-Varela, Michela Tantucci, Petra Mazzocchetti, Massimiliano Di Filippo, Cinzia Costa, Cristiano Spaccatini, Fabrizio Gardoni, Omar El-Agnaf, Calabresi Paolo

33/09 - TM4SF2 KNOCKOUT MICE DISPLAY SYNAPTIC DYSFUNCTIONS AND DEFICITS IN ASSOCIATIVE MEMORY Luca Murru Alessandra Folci, Elena Vezzoli, Edoardo Moretto, Silvia Bassani, Anna Longatti, Veronica Bianchi, Patrizia D’adamo, Maura Francolini, Maria Passafaro



34/09 - ALPHA-SYNUCLEIN PRODUCES NMDA-MEDIATED STRIATAL SYNAPTIC DYSFUNCTION Valentina Durante Alessandro Tozzi, Antonio de Iure, Ana Quiroga-Varela, Michela Tantucci, Petra Mazzocchetti, Cristiano Spaccatini, Massimiliano Di Filippo, Cinzia Costa, Omar El-Agnaf, Paolo Calabresi

35/09 - TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND (TRAIL) ATTENUATES THE EXPRESSION OF THE NA+/CA2+ EXCHANGER (NCX3) IN DIFFERENTIATED SH-SY5Y NEURONAL CELLS Oriana Valerio Giulia Di Benedetto, Vincenzo Lariccia, Renato Bernardini, Salvatore Amoroso, Giuseppina Cantarella

36/09 - AGOMELATINE TREATMENT INDUCES SPECIFIC AND TIME-DEPENDENT MODULATION OF RAT HIPPOCAMPAL MIRNAS AND RELATED TARGET GENES Mara Seguini Daniela Tardito, Veronica Rota, Ivan Merelli, Dario Corrada, Luciano Milanesi, Giorgio Racagni, Maurizio Popoli

37/09 - ROLE OF ATP P2Y1 RECEPTOR IN THE RAT DENTATE GYRUS AFTER A SEVERE ISCHEMIC INSULT Irene Fusco Elisabetta Coppi, Giovanna Maraula, Daniele Lana, Maria Grazia Giovannini, Tommaso Mello, Andrea Galli, Felicita Pedata, Anna Maria Pugliese

38/09 - ETHANOL MODULATES HYPERPOLARIZATION-ACTIVATED CATION CURRENTS (IH) IN RAT HIPPOCAMPAL CA3 PYRAMIDAL NEURONS: INVOLVEMENT OF THE AC/CAMP/PKA INTRACELLULAR PATHWAY Valentina Licheri Giuseppe Talani, Giovanni Biggio, Enrico Sanna

39/09 - FOOD RESTRICTION IN RATS IS ASSOCIATED WITH AN ENHANCED GLUTAMATERGIC SYNAPTIC PLASTICITY IN THE HIPPOCAMPAL CA1 FIELD: INVOLVEMENT OF CB1 RECEPTORS Giuseppe Talani Valentina Licheri, Francesca Biggio, Valentina Locci, Maria Cristina Mostallino, Laura Cocco, Laura Firino, Giacomo Sitzia, Giovanni Biggio, Enrico Sanna

40/09 - EFFECT OF PSYCHOSTIMULANT DESIGNER DRUGS ON BRAIN NEUROTRANSMITTERS Katarzyna Kaminska Karolina Noworyta-Sokolowska, Alexandra Jurczak, Anna Górska, Krystyna Golembiowska



41/09 - EFFECT OF SUB-CHRONIC ADMINISTRATION OF MDMA AND CAFFEINE ON MONOAMINE TRANSMITTERS AND PRODYNORPHIN GENE IN THE MOUSE BRAIN Anna Maria Górska Katarzyna Kaminska, Agnieszka Wawrzczak-Bargiela, Ryszard Przewlocki, Krystyna Golembiowska

42/09 - SYSTEMIC AND LOCAL EFFECTS OF ANTIDEPRESSANTS AND KETAMINE ON CATECHOLAMINE TRANSMISSION IN THE BED NUCLEUS OF STRIA TERMINALIS: A MICRODIALYSIS STUDY IN FREELY MOVING RATS Roberto Cadeddu Dragana Jadzic, Ezio Carboni

43/09 - FUNCTIONALIZED POLYMERIC NANOPARTICLES AS KEY TO OPEN BRAIN DOORS Corinne Portioli Michele Bovi, Marta Donini, Donatella Benati, Massimiliano Perduca, Stefano Dusi, Hugo Monaco, Marina Bentivoglio

44/09 - GAD67 IMMUNOREACTIVITY IN THE CENTRAL AMYGDALA AS A MARKER OF LONG-LASTING CHANGES IN NEURONAL ACTIVITY CAUSED BY ADOLESCENT PRE-EXPOSURE TO DRUGS OF ABUSE Annesha Sil Augusta Pisanu, Daniele Lecca, Andrea Scifo, Cristina Cadoni, Gaetano Di Chiara

45/09 - IMMUNOCHEMICAL LOCALIZATION OF GABAA RECEPTOR SUBUNITS IN THE FRESHWATER POLYP HYDRA VULGARIS (CNIDARIA, HYDROZOA) Andrea Locci Roberta Imperatore, Francesca Santoru, Patrizia Porcu, Luigia Cristino, Paola Pierobon, Alessandra Concas

46/09 - SELECTIVE ACTIVATION OF PARVALBUMIN- OR SOMATOSTATIN-EXPRESSING INTERNEURONS TRIGGERS EPILEPTIC SEIZURELIKE ACTIVITY IN MOUSE MEDIAL ENTORHINAL CORTEX Latefa Yekhlef Gianluca Breschi, Laura Lagostena, Giovanni Russo, Stefano Taverna

47/09 - FOXG1 ANTAGONIZES CORTICO-CEREBRAL ASTROGENESIS Clara Grudina Carmen Falcone, Nika Blecich, Manuela Santo, Antonello Mallamaci



POSTER SESSION 1 e 2 SLEEP, AUTONOMIC AND NEUROENDOCRINE SYSTEMS48/09 - METABOLIC FATE AND EFFLUX OF CHOLESTEROL IN THE

HIPPOCAMPUS OF DIABETIC MALE RAT Simone Romano Silvia Giatti, Marzia Pesaresi, Nico Mitro, Gaia Cermenati, Donatella Caruso, Roberto Cosimo Melcangi

49/09 - EFFECTS OF LEPTIN ON MOUSE CHROMAFFIN CELLS FIRING AND CATHECOLAMINES SECRETION Daniela Gavello David Vandael, Sara Gosso, Emilio Carbone, Valentina Carabelli

50/09 - T-TYPE CALCIUM CHANNELS IN MOUSE CHROMAFFIN CELLS: CHARACTERIZATION AND SENSITIVITY TO STRESSFUL STIMULI Chiara Calorio Andrea Marcantoni, Emilio Carbone

51/09 - AN INTEGRATED APPROACH FOR MORPHOFUNCTIONAL ANALYSIS OF DRGS IN NORMAL AND DIABETIC MICE Elisa Ciglieri Francesco Ferrini, Simone Tonti, Santa Di Cataldo, Elisa Ficarra, Chiara Salio

52/09 - TARGETING SUBSTANTIA NIGRA THROUGH OXYTOCIN RECEPTORS Laura Angioni Cristina Cocco, Antonio Argiolas, Gian Luca Ferri, Maria Rosaria Melis, Fabrizio Sanna

53/09 - EFFECTS OF PRENATAL STRESS EXPOSURE AND MATERNAL SEPARATION ON HPA AXIS RESPONSIVENESS AND BEHAVIOR IN YOUNG ADULT MALE RATS Francesca Biggio Valentina Locci, Giorgia Boero, Maria Giuseppina Pisu, Pierluigi Olla, Mariangela Serra

54/09 - SOCIAL ISOLATION INDUCES A DISREGULATION OF HPA AXIS ACTIVITY IN MALE RATS Maria Giuseppina Pisu Giorgia Boero, Pierluigi Olla, Francesca Biggio, Mariangela Serra

55/09 - ALTERED MATERNAL STYLE IN A MOUSE MODEL OF IDIOPATHIC AUTISM: A ROLE FOR OXYTOCIN? Maria Carla Giorgi Debora Cutuli, Alessia De Felice, Stefano Farioli Vecchioli, Gemma Calamandrei



56/09 - CXCL-10 AND SLEEP CHANGES AS BRAIN DISEASE BIOMARKERS IN EXPERIMENTAL SLEEPING SICKNESS Chiara Tesoriero Claudia Laperchia, Valeria Colavito, Valentina La Verde, Gigliola Grassi-Zucconi, Jean Rogers, Peter GE Kennedy, Paul Montague, Marina Bentivoglio

POSTER SESSION 1 e 2 COGNITION AND BEHAVIOUR 57/09 - REPEATED CYCLES OF CHRONIC INTERMITTENT ETHANOL

EXPOSURE ALTER GABAA RECEPTOR GENE EXPRESSION Paolo Follesa Gabriele Floris, Gino Paolo Asuni, Beniamina Mercante, Franca Deriu

58/09 - VOLUNTARY ETHANOL DRINKING IN GABAB KNOCK-OUT MICE: EFFECT OF GAMMA-HYDROXYBUTYRIC ACID Paolo Follesa Gabriele Floris, Gino Paolo Asuni, Beniamina Mercante, Franca Deriu

59/09 - EFFECT OF ACUTE AND CHRONIC ADMINISTRATION OF METHOXETAMINE ON BEHAVIOUR, MOOD AND REWARD Mary Tresa Zanda Silvia Antinori, Francesco Ciaccio, Anna Mutti, Laura Mancini, Laura Padovani, Maria Scherma, Sonia Aroni, Anna Lisa Muntoni, Walter Fratta, Paola Fadda, Cristiano Chiamulera, Liana Fattore

60/09 - BEHAVIOURAL PHENOTYPING OF CONDITIONAL CEREBELLAR SPECIFIC CHD7- DEFICIENT MICE Angela Caruso Kimberley Riegman, Caterina Michetti, Mara Sabbioni, Albert Basson, Cathy Fernandes, Maria Luisa Scattoni

61/09 - INTERACTION BETWEEN EARLY PSYCHOSOCIAL STRESS AND MAO-A ON PATHOLOGICAL AGGRESSION Alessandra Pardu Roberto Frau, Romina Pes, Silvia Fanni, Pierluigi Saba, Sean Godar, Simona Scheggi, Maria Graziella Demontis, Marco Bortolato, Paola Devoto



62/09 - INVOLVEMENT OF GLUTAMATE NMDA RECEPTORS IN THE ACUTE, LONG-TERM, AND CONDITIONED EFFECTS OF AMPHETAMINE ON RAT 50-KHZ ULTRASONIC VOCALIZATIONS Nicola Simola Giulia Costa, Micaela Morelli

63/09 - ROMAN HIGH- AND LOW-AVOIDANCE RATS DIFFER IN THE EXPRESSION OF PERK IN THE CEREBRAL CORTEX AND AMYGDALA DURING AVOIDANCE LEARNING Maria Antonietta Piludu Michela Rosas, Marta Sabariego, Valentina Giugliano, Osvaldo Giorgi, Elio Acquas, Maria Giuseppa Corda

64/09 - POSSIBLE ROLE OF DOPAMINE IN THE DIFFERENCES IN SEXUAL BEHAVIOUR BETWEEN ROMAN HIGH AND LOW AVOIDANCE RATS: BEHAVIORAL, PHARMACOLOGICAL AND NEUROCHEMICAL FINDINGS Fabrizio Sanna Maria Antonietta Piludu, Maria Giuseppa Corda, Maria Rosaria Melis, Osvaldo Giorgi, Antonio Argiolas

65/09 - SPATIAL LEARNING IN INDIVIDUALS UNDERGOING ALCOHOL DETOXIFICATION Valentina Carito Giovanna Coriale, Marco Fiore, Mauro Ceccanti

66/09 - MATERNAL IMMUNE ACTIVATION IN MICE: SHORT AND LONG TERM NEUROBEHAVIOURAL EFFECTS IN OFFSPRING Daniele Vigli Maria Luisa Scattoni, Gianmauro Palombelli, Rossella Canese, Laura Ricceri

67/09 - ADOLESCENCE VERSUS ADULTHOOD: DIFFERENTIAL EFFECTS OF DRUGS OF ABUSE ON MESOLIMBIC DOPAMINE TRANSMISSION Silvia Corongiu Christian Dessì, Cristina Cadoni

68/09 - CHANGES IN GLUTAMATE RELEASE AND RELATED MOLECULAR MECHANISMS INDUCED BY CHRONIC MILD STRESS IN VULNERABLE AND RESILIENT RATS. MODULATION BY KETAMINE Paolo Tornese Laura Musazzi, Nathalie Sala, Francesco Brizzi, Giorgio Racagni, Maurizio Popoli



69/09 - TIME-DEPENDENT FUNCTIONAL, STRUCTURAL, AND BEHAVIORAL CHANGES INDUCED BY ACUTE STRESS IN RATS. LOOKING FOR NEW TARGETS FOR NEUROPSYCHIATRIC THERAPIES Nathalie Sala Laura Musazzi, Paolo Tornese, Nicoletta Nava, Giulia Treccani, Chiara Bazzini, Francesca Sala, Roberta Luciano, Giorgio Racagni, Jens Randel Nyengaard, Gregers Wegener, Maurizio Popoli

70/09 - EFFECTS OF 25I-NBOME, A NEW POTENT 5HT2A AGONIST, ON THE CENTRAL NERVOUS SYSTEM OF RODENTS Cristina Miliano Andrea Ossato, Matteo Marti, Barbara Loi, Giovanna Mulas, Anna Carta, Gaetano Di Chiara, Maria Antonietta De Luca

71/09 - EFFECTS OF WITHANIA SOMNIFERA DUNAL ON ETHANOL- AND MORPHINE-ELICITED CONDITIONED PLACE PREFERENCE IN MICE Michela Rosas Simona Porru, Liliana Spina, Rosanna Longoni, Sanjay Kasture, Stefania Ruiu, Alessandro Orrù, Alessandra Peana, Elio Acquas

72/09 - EFFECTS OF WITHANIA SOMNIFERA DUNAL ON ETHANOL SELF-ADMINISTRATION IN RATS Elio Acquas Michela Rosas, Simona Porru, Liliana Spina, Sanjay Kasture, Alessandra Peana

73/09 - ROLE OF PHOSPHORYLATED ERK IN THE MOTIVATIONAL PROPERTIES OF ETHANOL AS DETERMINED BY CONDITIONED PLACE PREFERENCE AND CONDITIONED PLACE AVERSION Liliana Spina Michela Rosas, Simona Porru, Rosanna Longoni, Alessandra Peana, Elio Acquas

74/09 - EFFECT OF L-DOPA ON COCAINE-TAKING AND COCAINE-SEEKING BEHAVIOR IN RATS Silvia Antinori Liana Fattore, Pierluigi Saba, Walter Fratta, Gian Luigi Gessa, Paola Devoto



POSTER SESSION 1 e 2 SENSORY AND MOTOR SYSTEM 75/09 - EFFECT OF 5-ALPHA REDUCTASE INHIBITION IN L-DOPA-INDUCED

DYSKINESIA Silvia Fanni Roberto Frau, Elisabetta Tronci, Camino Fidalgo, Carlo Lisci, Alessandra Pardu, Romina Pes, Pierluigi Saba, Paola Devoto, Marco Bortolato, Manolo Carta

76/09 - NEUROCHEMICAL MECHANISMS INVOLVED IN MDMA-INDUCED NEUROTOXICITY IN MICE Giulia Costa Nicola Simola, Micaela Morelli

77/09 - CHRONIC HYPOXIA UP-REGULATES CAV3.2 T-TYPE CALCIUM CHANNELS IN RAT SENSORY NEURONS Chiara Calorio Andrea Marcantoni, Valentina Comunanza, Federico Bussolino, Emilio Carbone

78/09 - UMAN RECOMBINANT NGF EYE DROPS IN OPTIC NERVE CRUSH MODEL: MODULATORY AND REPARATIVE EFFECTS IN THE RETINA AND VISUAL BRAIN AREAS Sara De Nicolò Pamela Rosso, Louise Mesentier-Louro, Alessandro Lambiase, Paolo Rama, Paola Tirassa

79/09 - VISUAL PROCESSING IN A MOUSE MODEL OF FOCAL NEOCORTICAL EPILEPSY Matteo Caleo Eleonora Vannini, Alessandro Panarese, Alberto Mazzoni, Marta Pietrasanta, Stefano Lai, Silvestro Micera, Laura Restani

80/09 - L-DOPA CHRONIC TREATMENT INCREASES REACTIVE MICROGLIA AND TNF- ALPHA PRODUCTION IN THE 6-OHDA LESIONED STRIATUM Giovanna Mulas Elisabetta Pillai, Elena Espa, Sandro Fenu, Daniela Lecca, Saturnino Spiga, Anna Rosa Carta



Friday 9 October 2015 Saturday 10 October 2015

81/09 - TRANSACCADIC SPATIAL STABILITY AND PRE-SACCADIC PERCEPTION Paola Binda Guido Marco Cicchini, David Burr, Maria Concetta Morrone

82/09 - VISUAL BOLD RESPONSE IN LATE-BLIND SUBJECTS WITH ARGUS II RETINAL PROSTHESIS Elisa Castaldi Marco Cicchini, Laura Cinelli, Laura Biagi, Michela Tosetti, Stanislao Rizzo, Concetta Morrone

83/09 - EXPERIENCE-DEPENDENT DNA METHYLATION REGULATES PLASTICITY IN THE DEVELOPING VISUAL CORTEX Tommaso Pizzorusso Debora Napoli, Paola Tognini, Jonida Tola, Davide Silingardi, Della ragione Floriana, Maurizio D’Esposito


POSTER SESSION 1 e 2 DISORDERS OF THE NERVOUS SYSTEM

1/10 - FUS PROTEIN IS MISLOCALIZED IN THE CYTOPLASM OF CULTURED SKIN FIBROBLASTS FROM PRECLINICAL FUS P525L MUTATION CARRIERS Margherita Lo Bello Francesca Di Fini, Francesca L Conforti, Vincenzo La Bella, Rossella Spataro

2/10 - CATESTATIN AND MUSCIMOL INTERACTION IN AMYGDALA AND BRAINSTEM OF SPONTANEOUSLY HYPERTENSIVE RATS EXERT ANTIHYPERTENSIVE AND NEUROPROTECTIVE EFFECTS Ennio Avolio Sushil K Mahata, Maria Mele, Raffaella Alò, Gilda Fazzari, Teresa Pasqua, Tommaso Angelone, Maria Carmela Cerra, Marcello Canonaco



3/10 - DIFFERENTIAL MODULATION OF DOPAMINE-GLUTAMATE POSTSYNAPTIC INTERACTION BY CAFFEINE AND NICOTINE AND THEIR COMBINATION WITH ANTIPSYCHOTICS: RELEVANCE TO PSYCHIATRIC DISEASES Elisabetta Filomena Buonaguro Livia Avvisati, Gianmarco Latte, Giovanna Fico, Camilla Avagliano, Federica Marmo, Felice Iasevoli, Carmine Tomasetti, Andrea de Bartolomeis

4/10 - NICOTINIC ACETYLCHOLINE RECEPTORS CONTAINING ALFA5 SUBUNIT REGULATE DOPAMINE AND SEROTONIN BUT NOT ACETYLCHOLINE RELEASE IN NUCLEUS ACCUMBENS: AN IN VIVO MICRODIALYSIS STUDY USING ALFA5 KO MICE Antonietta Vilella Giuseppe Cannazza, Natalia Stasiak, Michele Zoli

5/10 - SIGNIFICANT CORRELATION BETWEEN LONG-TERM LITHIUM TREATMENT AND LEUKOCYTE TELOMERE LENGTH IN PATIENTS WITH BIPOLAR DISORDER Claudia Pisanu Gioia Baggiani, Donatella Congiu, Carla Melis, Paola Niola, Paola Caria, Giovanni Severino, Roberta Vanni, Alberto Bocchetta, Maria Del Zompo, Caterina Chillotti, Alessio Squassina

6/10 - DYSREGULATION OF GPR17, A NEW KEY ACTOR INVOLVED IN OLIGODENDROGENESIS, IN A RODENT MODEL OF MULTIPLE SCLEROSIS: IMPLICATIONS FOR RE-MYELINATION STRATEGIES Giusy Tindara Coppolino Davide Lecca, Davide Marangon, Francesca Viganò, Gianluca Menichetti, Marta Fumagalli, Elisabetta Bonfanti, Roberto Furlan, Leda Dimou, Maria Pia Abbracchio

7/10 - INHIBITION OF MONOACYLGLYCEROL LIPASE ACTIVITY MODULATES THE ACTIVATION OF BRAIN STRUCTURES RELEVANT FOR MIGRAINE PATHOGENESIS Rosaria Greco Tiziano Bandiera, Antonina Stefania Mangione, Chiara Demartini, Giuseppe Nappi, Giorgio Sandrini, Fabio Blandini, Daniele Piomelli, Cristina Tassorelli

8/10 - NOVEL ANTISENSE AND PROTEIN CODING GENE VARIATIONS IDENTIFIED BY NGS IN PARKINSON’S DISEASE Marialuisa Valente Roberta Zangaglia, Stella Gagliardi, Ivana Ricca, Susanna Zucca, Fabio Blandini, Claudio Pacchetti, Cristina Cereda


9/10 - ALTERATIONS OF SYNAPTIC MECHANISMS AND EXCESSIVE GLUTAMATE RELEASE IN THE SPINAL CORD OF SOD1G93A MICE Tiziana Bonifacino Marco Milanese, Laura Musazzi, Elena Gallia, Luca Cattaneo, Giulia Treccani, Franco Onofri, Maurizio Popoli, Giambattista Bonanno

10/10 - THE TUMOR SUPPRESSOR NF2/MERLIN INDUCES SCHWANN CELL CHANGES THROUGH HIPPO-DEPENDENT MECHANISMS Simona Melfi Alessandra Colciago, Veronica Bonalume, Giuseppe Giannotti, Lucia Caffino, Fabio Fumagalli, Valerio Magnaghi

11/10 - A NEW CLINICALLY RELEVANT MURINE MODEL OF SPINAL CORD INJURY MIMICKING THE PATHOLOGICAL FEATURES OF COMPLETE PARALYSIS IN HUMANS Valentina Vacca Flaminia Pavone, Siro Luvisetto, Sara Marinelli

12/10 - HYDROGEN SULPHIDE: A GLIAL FACTOR ENDOGENOUSLY OVERPRODUCED IN AMYOTROPHIC LATERAL SCLEROSIS THAT ENHANCES MOTOR NEURON DEATH Alida Spalloni Viviana Greco, Ezia Guatteo, Nicola B. Mercuri, Andrea Urbani, Patrizia Longone

13/10 - TREATMENT-RESISTANT PSYCHOSIS IN PATIENTS WITH AUTOIMMUNE THYROIDITIS: A CASE SERIES Francesco Traccis Gioia Baggiani, Andrea Loviselli, Alberto Bocchetta

14/10 - A NEW TOOL FOR STORING AND INTERROGATING GENOTYPE-PHENOTYPE CORRELATIONS TO STUDY BIPOLAR DISORDER Carla Melis Patricia Rodriguez-Tomé, Raffaella Ardau, Caterina Chillotti, Maria Del Zompo, Alessio Squassina, Giovanni Severino

15/10 - SUMOYLATION OF NCX3 BY SUMO1 TAKES PART IN THE BRAIN NEUROPROTECTION INDUCED BY ISCHEMIC PRECONDITIONING Ornella Cuomo Giuseppe Pignataro, Rossana Sirabella, Serenella Anzilotti, Pasquale Molinaro, Antonella Scorziello, Claudia Savoia, Maria Josè Sisalli, Gianfranco Di Renzo, Lucio Annunziato

Saturday 10 October 2015 Saturday 10 October 2015


16/10 - FOXG1 OVEREXPRESSION IN NEOCORTICAL NEURONS: A VALUABLE TOOL TO DISSECT MECHANISMS UNDERLYING WEST SYNDROME VARIANTS LINKED TO FOXG1 GENE DUPLICATION Moira Pinzan Minh Do Duc, Simone Chiola, Giovanni Provenzano, Yuri Bozzi, Antonello Mallamaci

17/10 - SUPEROXIDE DISMUTASE 1: A NEW FUNCTION IN THE NUCLEAR COMPARTMENT Orietta Pansarasa Stella Gagliardi, Michela Dell’Orco, Matteo Bordoni, Sabrina La Salvia, Luca Diamanti, Elisa Maffioli, Gabriella Tedeschi, Cristina Cereda

18/10 - SIMILARITIES AND DIFFERENCES BETWEEN ALS AND IBM Orietta Pansarasa Andrea Cortese, Matteo Bordoni, Francesca Polveraccio, Lorenzo Drufuca, Emanuele Buratti, Cristina Cereda

19/10 - SUPRAMODAL MIRROR AGNOSIA IN PATIENTS WITH PERIVENTICULAR LEUKOMALACIA Elisa Castaldi Francesca Tinelli, Guido Marco Cicchini, Laura Biagi, Maria Concetta Morrone

20/10 - CAN LOSS OF HETEROZYGOSITY EXPLAIN CEREBRAL CAVERNOUS MALFORMATIONS’ DEVELOPMENT IN PATIENTS WITH NO CCM GENES GERMLINE MUTATIONS? Concetta Scimone Concetta Alafaci, Alessia Ruggeri, Luigi Donato, Carmela Rinaldi, Rosalia D’Angelo, Antonina Sidoti

21/10 - ROLE OF MELOXICAM ON GLUTAMATE AND GABA CYCLE MODIFICATIONS IN RAT ORGANOTYPIC HIPPOCAMPAL SLICE CULTURES EXPOSED TO OXYGEN-GLUCOSE DEPRIVATION Elisa Landucci Irene Lorenzo Llorente, Elisabetta Gerace, Arsenio Fernandez-Lopez, Domenico Pellegrini-Giampietro

22/10 - IMPAIRMENT OF CORTICO-STRIATAL GLUTAMATERGIC SYNAPSES IN TWO MOUSE MODELS OF HUNTINGTON’S DISEASE (HD) Gerardo Biella Francesca Talpo, Chiara Zuccato, Cattaneo Elena, Giulio Sancini, Mauro Toselli



23/10 - PRION PROTEIN INFLUENCES ALPHA-SYNUCLEIN AGGREGATES SPREADING IN MICE Lara Masperone Suzana Aulic, Elisa Isopi, Joanna Narkiewicz, Giuseppe Legname

24/10 - TRAF6 INVOLVEMENT IN PRION DISEASE: A POSSIBLE CROSSTALK AMONG NEURODEGENERATIVE DISEASES Lara Masperone Silvia Zucchelli, Giuseppe Legname

25/10 - FUNCTIONAL CHARACTERIZATION OF A NOVEL MUTATION AFFECTING THE FIRST ARGININE IN THE S4 SEGMENT OF KV7.2 CHANNEL CAUSING EARLY-ONSET EPILEPTIC ENCEPHALOPATHY Francesco Miceli Maria Virginia Soldovieri, Paolo Ambrosino, Edward C. Cooper, Maurizio Taglialatela

26/10 - KNOCKING OUT THE NA+/CA2+ EXCHANGER NCX3 IMPAIRS OLIGODENDROCYTE LINEAGE RESPONSES, ANTICIPATES THE ONSET, AND INCREASES THE SEVERITY OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS Antonella Casamassa Francesca Boscia, Claudia La Rocca, Giuseppe Matarese, Lucio Annunziato

27/10 - RHES INFLUENCES STRIATAL CAMP/PKA-DEPENDENT SIGNALING AND SYNAPTIC PLASTICITY IN A GENDER-SENSITIVE FASHION Veronica Ghiglieri Francesco Napolitano, Barbara Pelosi, Valentina Pendolino, Carmela Giampà, Chiara Schepisi, Sara Migliarini, Anna Di Maio, Daniela Vitucci, Maria Mancini, Giuseppe Sciamanna, Giacomo Maddaloni, Francesco Errico, Robert Nisticò, Massimo Pasqualetti, Barbara Picconi, Alessandro Usiello

28/10 - RHES REGULATES DOPAMINE D2 RECEPTOR TRANSMISSION IN STRIATAL CHOLINERGIC INTERNEURONS Giuseppe Sciamanna Francesco Napolitano, Barbara Pelosi, Paola Bonsi, Daniela Vitucci, Tommaso Nuzzo, Daniela Punzo, Veronica Ghiglieri, Giulia Ponterio, Massimo Pasqualetti, Antonio Pisani, Alessandro Usiello

29/10 - VGF PEPTIDES IN THE NSC-34 MOTONEURONAL CELL LINE: SELECTIVE MODULATION UPON OXIDATIVE STRESS AND POTENTIAL NEUROPROTECTIVE ROLE OF TLQP-21 Roberta Pilleri Carla Brancia, Barbara Noli, Cristina Cocco, Valeria Sogos, Gian Luca Ferri



30/10 - A382T TARDBP GENE MUTATION ALTERS STRESS GRANULE DYNAMIC IN CULTURED FIBROBLASTS FROM ALS PATIENTS Paola Coni Carla Brancia, Andrea Floris, Ilaria Bellini, Sandro Orrù, Valeria Sogos

31/10 - IMPAIRMENT OF SPIKE TIMING DEPENDENT PLASTICITY AT IMMATURE MOSSY-FIBER–CA3 SYNAPSES OF MICE CARRYING THE R451 MUTATION OF NL3 IS DUE TO A LOSS OF FUNCTION Martina Sgritta Andrzej Jan Bialowas, Grzegorz Wiera, Enrico Cherubini

32/10 - MOLECULAR MECHANISMS INVOLVED IN MITOCHONDRIAL DYNAMICS IN AN IN VITRO MODELS OF BRAIN ISCHEMIA Gaetano Ianniello Maria Josè Sisalli, Lucio Annunziato, Antonella Scorziello

33/10 - CHARACTERIZATION OF THE NEURONAL ALTERATIONS IN THE SHANK1/SHANK3 DOUBLE KNOCK OUT MOUSE AS ANIMAL MODEL FOR SHANKOPATHIES Adele Mossa Luisa Ponzoni, Lorenza Culotta, Mariaelvina Sala, Carlo Sala, Chiara Verpelli

34/10 - CHARACTERIZATION OF SELECTIVE MIRNAS EXPRESSION IN BLOOD AND BRAIN SAMPLES AFTER THE NEUROPROTECTIVE APPROACH OF REMOTE POSTCONDITIONING Pasquale Cepparulo Antonio Vinciguerra, Ornella Cuomo, Paola Brancaccio, Gianfranco Di Renzo, Lucio Annunziato, Giuseppe Pignataro

35/10 - MICROVESICLES IN NEURODEGENERATIVE DISEASES:A CROSS-TALK AMONG DIFFERENT CELL TYPES Sabrina La Salvia Daisy Sproviero, Federico Colombo, Orietta Pansarasa, Stella Gagliardi, Laura Porretti, Cristina Cereda

36/10 - EFFECT OF PURIFIED MURINE NGF ON ISOLATED PHOTORECEPTORS OF A RODENT DEVELOPING RETINITIS PIGMENTOSA Maria Luisa Rocco Bijorn Omar Balzamino, Pamela Petrocchi Passeri, Alessandra Micera, Luigi Aloe



37/10 - PHARMACOLOGICAL RESCUE OF KCNQ2 CHANNELS CARRYING EARLY-ONSET EPILETIC ENCEPHALOPATHY MUTATIONS Michela De Maria Maria Virginia Soldovieri, Paolo Ambrosino, Ilaria Mosca, Francesco Miceli, Pasquale Striano, Sarah Weckhuysen, Edward C Cooper, Maurizio Taglialatela

38/10 - GENETIC VARIATION IN RASD2 MODULATES PSYCHOTOMIMETIC DRUG EFFECTS IN MICE AND SCHIZOPHRENIA-RELATED PHENOTYPES IN HUMANS Francesco Napolitano Daniela Vitucci, Annabella Di Giorgio, Francesco Errico, Maria Teresa Attrotto, Barbara Gelao, Leonardo Fazio, Anna Di Maio, Valentina Marsili, Paolo Taurisano, Giuseppe Blasi, Barbara Pelosi, Massimo Pasqualetti, Alessandro Bertolino, Alessandro Usiello

39/10 - EFFECT OF RESVERATROL ON PLASMATIC MOLECULAR INDICATORS OF BRAIN TISSUE RESPONSE TO THE HYPOPERFUSION/REPERFUSION CHALLENGE Laura Poddighe Maria Pina Serra, Marianna Boi, Cristina Picci, Gianfranca Carta, Elisabetta Murru, Sara Lisai, Annarita Sirigu, Maria Collu, Sebastiano Banni, Marina Quartu

40/10 - RESVERATROL VIA SIRTUIN-1 DOWNREGULATES RE1-SILENCING TRANSCRIPTION FACTOR (REST) EXPRESSION PREVENTING PCB-95- INDUCED NEURONAL CELL DEATH Giusy Laudati Natascia Guida, Serenella Anzilotti, Paolo Montuori, Gianfranco Di Renzo, Lorella Maria Teresa Canzoniero, Luigi Formisano

41/10 - TRANSPLANTED ADULT STEM/NEUROPROGENITOR CELLS (ANPCS) IN RODENT MODELS OF PARKINSON’S DISEASE: CHARACTERIZATION, PROPERTIES AND IN VIVO EVIDENCE OF NIGROSTRIATAL DOPAMINERGIC NEURORESTORATION Francesca L’Episcopo Cataldo Tirolo, Nunzio Testa, Maria Francesca Serapide, Luca Peruzzotti Jametti, Stefano Pluchino, Bianca Marchetti

42/10 - SHEDDING VESICLES RELEASE FROM A HUMAN MICROGLIAL CELL LINE: A TOOL FOR STUDYING MICROVESICLES BIOLOGY Federico Colombo Giacomo Casella, Annamaria Finardi, Roberto Furlan



43/10 - NITRATED P53 AS AN EARLY BIOMARKER OF UNBALANCE REDOX STATUS IN ALZHEIMER’S DISEASE (AD) Daniela Uberti Mariagrazia Marziano, Abate Giulia, Maurizio Memo

44/10 - INVOLVEMENT OF CENTRAL HISTAMINERGIC SYSTEM IN THE PPAR-ALPHA LIGANDS INDUCED ANALGESIC AND ANTIDEPRESSANT-LIKE EFFECTS IN MICE Alessia Costa Patrizio Blandina, Carla Ghelardini, Maria Beatrice Passani, Gustavo Provensi

45/10 - CONFORMATIONALLY ALTERED P53 AFFECTS NEURON BIOLOGICAL FUNCTIONALITY GIULIA ABATE Marigrazia Marziano Daniela Uberti, Maurizio Memo

46/10 - THE PROTECTION INDUCED BY L-BMAA-INDUCED PRECONDITIONING IN AMYOTROPHIC LATERAL SCLEROSIS MICE BEARING G93A MUTATION IS MEDIATED BY MODULATION OF PROTEINS CONTROLLING IONIC HOMEOSTASIS Giuseppe Simeone Serenella Anzilotti, Antonio Vinciguerra, Ornella Cuomo, Paola Brancaccio, Pasquale Cepparulo, Pierpaolo Cerullo, Lucio Annunziato, Giuseppe Pignataro

47/10 - A ROLE FOR ENVIRONMENTAL CHEMICALS IN AUTISM ETIOLOGY: GESTATIONAL EXPOSURE TO LOW DOSES OF THE ORGANOPHOSPHATE INSECTICIDE CHLORPYRIFOS ENHANCES OXIDATIVE STRESS IN A MOUSE MODEL OF AUTISM Alessia De Felice Luisa Minghetti, Anita Greco, Gemma Calamandrei

48/10 - CHF5074 (CSP-1103) INDUCES MICROGLIA ALTERNATIVE ACTIVATION IN PRIMARY GLIAL CULTURES EXPOSED TO BETA-AMYLOID AND IN PLAQUE-FREE TG2576 MICE Vanessa Porrini Annamaria Lanzillotta, Caterina Branca, Marina Benarese, Edoardo Parrella, Luca Lorenzini, Laura Calzà, Raffaella Flaibani, PierFranco Spano, Bruno Pietro Imbimbo, Marina Pizzi



49/10 - NEUTRALIZATION OF THE APOPTOTIC EFFECTS OF THE NEUROTOXIC CYTOKINE TRAIL BY A NAN0PARTICLE-CONJUGATED SPECIFIC MONOCLONAL ANTIBODY Nicole Ronsisvalle Giulia Di Benedetto, Teresa Musumeci, Giovanni Puglisi, Renato Bernardini, Giuseppina Cantarella

50/10 - THE TRAIL/GITRL INTERPLAY IN NEURODEGENERATIVE PROCESSES IN THE HCN-2 HUMAN CORTICAL CELL LINE IN VITRO Giulia Di Benedetto Nicole Ronsisvalle, Renato Bernardini, Giuseppina Cantarella

51/10 - FUNCTIONAL READOUTS OF NEURONS DIFFERENTIATED FROM HIPS DERIVED FROM PATIENTS AFFECTED BY HUNTINGTON’S DISEASE Elisabetta Cesana Paola Conforti, Elena Cattaneo, Mauro Toselli, Gerardo Biella

52/10 - IN VIVO DOPAMINE AGONIST PROPERTIES OF ROTIGOTINE: ROLE OF D1 AND D2 RECEPTORS Sandro Fenu Elena Espa, Augusta Pisanu, Gaetano Di Chiara

53/10 - WHITE MATTER DIFFUSION PARAMETERS IN MIGRAINE WITH AND WITHOUT AURA Nikoletta Szabo Andras Kiraly, Peter Farago, Gergo Csete, Eszter Toth, Krisztian Kocsis, Arpad Pardutz, Delia Szok, Janos Tajti, Laszlo Vecsei, Z Tamas Kincses

54/10 - NCX1 EXCHANGER COOPERATES WITH CALRETININ TO CONFER PRECONDITIONING-INDUCED TOLERANCE AGAINST CEREBRAL ISCHEMIA IN THE STRIATUM Valeria de Rosa Francesca Boscia, Antonella Casamassa, Agnese Secondo, Alba Esposito, Anna Pannaccione, Rossana Sirabella, Giuseppe Pignataro, Ornella Cuomo, Antonio Vinciguerra, Lucio Annunziato

55/10 - EARLY STAGE DETECTION OF ALPHA SYNUCLEIN ACCUMULATION INDUCED CHANGES IN TRANSGENIC MOUSE MODEL OF PARKINSON DISEASE: A DIFFUSION KURTOSIS IMAGING STUDY Anas Arab Amit Khairnar, Jana Kucerova, Peter Latta, Nikoletta Szabo



56/10 - ON THE USE OF THE POSITIVE AND NEGATIVE SYNDROME SCALE IN RANDOMIZED CLINICAL TRIALS Giorgio Marchese Eraldo Nicotra, Gianluca Casu, Sara Piras, Mario Palomba

57/10 - EFFECTS PRODUCED BY M2 MUSCARINIC RECEPTOR ACTIVATION IN BRAIN TUMORS: POSSIBLE THERAPEUTIC IMPLICATIONS Ilaria Cristofaro Francesca Mattei, Francesco Alessandrini, Zaira Spinello, Maria Di Bari, Viviana Orlando, Luciano Conti, Ada Maria Tata

58/10 - NEUROPROTECTIVE AND ANTI-INFLAMMATORY PROPERTIES OF MDG548, A NOVEL PPARG AGONIST, IN CHRONIC MPTP MODEL OF PARKINSON DISEASE Anna R. Carta Daniela Lecca, Giovanna Mulas, Andrea Diana

59/10 - METFORMIN REVERSES THE DOPAMINERGIC NEUROTOXICITY INDUCED BY REPEATED 3,4-METHYLENEDIOXYMETHAMPHETAMINE ADMINISTRATIONS Pier Francesca Porceddu Ismail Ishola, Micaela Morelli

60/10 - THE PHARMACOLOGICAL PROFILE OF THE DUAL RECEPTOR GPR17 Gabriella Marucci Michela Buccioni, Diego Dal Ben, Catia Lambertucci, Claudia Santinelli, Andrea Spinaci, Ajiroghene Thomas, Maria Pia Abbracchio, Rosaria Volpini

61/10 - A COMPREHENSIVE STUDY ON OLEUROPEIN AGLYCONE BENEFICIAL EFFECTS IN THE TGCRND8 MOUSE MODEL OF ASS DEPOSITION: A MECHANISTIC INSIGHT Daniela Pantano Pamela Nardiello, Leonardo Cavone, Andrea Lapucci, Ilaria Luccarini, Massimo Stefani, Fiorella Casamenti

62/10 - TIME-COURSE OF THE PROTECTIVE EFFECT OF SELECTIVE ADENOSINE A2A RECEPTOR AGONISTS AND ANTAGONISTS AFTER BRAIN FOCAL ISCHEMIA IN THE RAT Ilaria Dettori Alessia Melani, Lucrezia Cellai, Felicita Pedata



63/10 - ALTERED ADULT NEUROGENESIS AND ENHANCED SEIZURE PROPENSITY IN OLIGOPHRENIN-1 KNOCK-OUT MICE, A MURINE MODEL OF X-LINKED INTELLECTUAL DISABILITY Matteo Caleo Manuela Allegra, Cristina Spalletti, Beatrice Vignoli, Stefano Azzimondi, Irene Busti, Marco Canossa

64/10 - OREXINERGIC NEURONS IN MURINE MODELS OF ALZHEIMER’S DISEASE Anna Andrioli Amenu Tolera Wirtu, Idris Azeez, Sophie Dix, Jill C. Richardson, Marina Bentivoglio

65/10 - NEW THERAPEUTIC APPROACH FOR NEUROPATHIC PAIN: CELL AUTOPHAGY MODULATION VIA ENERGY BALANCE REGULATION Federica De Angelis Valentina Vacca, Francesca Nazio, Sara Marinelli

66/10 - CHOLINERGIC SYSTEM ALTERATIONS IN MULTIPLE SCLEROSIS: STUDIES IN RR-MS PATIENTS AND IN EAE MODEL Ada Maria Tata Maria Di Bari, Giovanni Di Pinto, Samanta Sperduti, Sabrina Galizia, Rocio Alvarez, Marta Di Nicola, Chiara D’Angelo, Viviana Orlando, Guadalupe Mengod, Valentina Gatta, Marcella Reale

67/10 - ROLE OF N-ACYLETHANOLAMINE-HYDROLYZING ACID AMIDASE IN (NEURO) INFLAMMATION Silvia Pontis Valeria Capurro, Maria Summa, Natalia Realini, Alison Ribeiro, Ana Gujarro, Andrea Armirotti, Angelo Reggiani, Daniele Piomelli

68/10 - THE SMALL GTP-BINDING PROTEIN RHES INFLUENCES MIDBRAIN DOPAMINERGIC NEURONS: BEHAVIORAL AND BIOCHEMICAL STUDIES Annalisa Pinna Francesco Napolitano, Giulia Costa, Jadwiga Wardas, Pier Francesca Porceddu, Maria Antonietta Casu, Liliana Contu, Alessandro Usiello, Micaela Morelli

69/10 - MOTOR AND COGNITIVE CHARACTERIZATION OF RHES KO FEMALE MICE Liliana Contu Francesco Napolitano, Giulia Costa, Pier Francesca Porceddu, Jadwiga Wardas, Annalisa Pinna, Alessandro Usiello, Micaela Morelli



70/10 - THE MONOMERIC GTP-BINDING PROTEIN RHES INFLUENCES THE NUMBER OF MIDBRAIN DOPAMINERGIC NEURON AND THE MOTOR DISTURBANCES ASSOCIATED TO L-DOPA IN 6-OHDA-LESIONED MICE Alessandro Usiello Francesco Napolitano

71/10 - ENDOCANNABINOIDS LEVELS IN SPECIFIC CEREBRAL AREAS OF RAT FOLLOWING NITROGLYCERIN ADMINISTRATION: A POSSIBLE ROLE IN MIGRAINE PAIN Chiara Demartini Rosaria Greco, Tiziano Bandiera, Ana Guijarro, Antonina Stefania Mangione, Andrea Armirotti, Giuseppe Nappi, Fabio Blandini, Giorgio Sandrini, Daniele Piomelli, Cristina Tassorelli

72/10 - HEART RATE VARIABILITY (HRV) AND CARDIOVASCULAR MODULATION IN PARKINSON’S DISEASE PATIENTS WITH TREMOR DOMINANT AND AKINETIC RIGID DOMINANT SUBTYPES Paolo Solla Christian Cadeddu, Antonino Cannas, Martino Deidda, Nicola Mura, Giuseppe Mercuro, Francesco Marrosu

73/10 - ENDOCANNABINOID SYSTEM: POSSIBLE NEW TARGET IN THE TREATMENT OF ANOREXIA NERVOSA Roberto Collu Maria Scherma, Valentina Satta, Jessica Bratzu, Maria Paola Castelli, Maria Francesca Boi, Paolo Usai, Liana Fattore, Paola Fadda, Walter Fratta

74/10 - ALS MODELS, A CONTRIBUTE FROM PATIENT’S LYMPHOBLASTOID CELL CULTURE Orietta Pansarasa Matteo Bordoni, Sabrina La Salvia, Marialuisa Valente, Lorenzo Drufuca, Luca Diamanti, Stella Gagliardi, Cristina Cereda

75/10 - CHARACTERIZATION OF THE INTERACTION BETWEEN ALPHA-SYNUCLEIN AND PRION PROTEIN: A PUTATIVE OVERLAP OF TWO NEURODEGENERATIVE DISEASES Giuseppe Legname

76/10 - TRACTOGRAPHY OF WHITE MATTER CONNECTIONS PREDICTS FOR VASCULAR COGNITIVE IMPAIRMENT IN HYPERTENSIVE PATIENTS Daniela Carnevale Lorenzo Carnevale, Giulio Selvetella, Daniela Cugino, GIovanni Grillea, Giuseppe Lembo



77/10 - EFFECT OF SIGMA-1 RECEPTOR (S1R) AGONISTS ON THE DISEASE PROGRESSION OF SOD1.G93A MICE. LIGHTS AND SHADOWS Daniela Curti Nicola Secomandi, Antonio Vallarola, Marco Peviani, Nicole Sarno, Alessandro Petese, AnnaMaria Marra, Daniela Rossi, Simona Collina

78/10 - INTENSIVE REHABILITATION ENHANCES LYMPHOCYTE BDNF-TRKB SIGNALING IN PATIENTS WITH PARKINSON’S DISEASE Giuseppe Frazzitta Cecilia Fontanesi, Svetlana Kvint, Davide Ferrazzoli, Rossana Bera, Alessandro Di Rocco, Gianni Pezzoli, Angelo Quartarone, Hoau Yan Wang, Maria Felice Ghilardi

79/10 - PHARMACOLOGICAL CHARACTERIZATION OF THE SYNTHETIC CANNABIMIMETIC COMPONENTS OF “SPICE” DRUGS: FOCUS ON ABUSE LIABILITY Barbara Loi Maria Antonietta De Luca, Cristina Miliano, Alessandra Porcu, Mariella Martorelli, Colin Davidson, Maria Paola Castelli, Fabrizio Schifano, Gaetano Di Chiara

80/10 - EPIGENETIC AND TRANSCRIPTIONAL DYSFUNCTION IN ISCHEMIC BRAIN INJURY AND HUNTINGTON’S DISEASE: FROM MECHANISMS TO THERAPEUTIC CANDIDATES Ferah Yildirim Christopher W. Ng, Theresa A. Gipson, Malini Vashishtha, Christoph Harms, Andreas Meisel, Leslie M. Thompson, David E. Housman, Ernest Fraenkel


Cagliari October • 8th - 11th •2015 53

SCIENTIFIC INFORMATION

PostersResearchers have been kindly invited to submit scientific abstracts that have been reviewed by the examining Scientific Committee. All accepted posters will be presented in a dedicated area of the Congress Center.All poster will have to be on the display for the whole day the poster session refers to, October 9 and 10.Poster presenters are asked to remove their work at the end of each day.The Organizing Secretariat takes no responsibility for the posters that will not be removed.

SINS SecretarySecretary of SINS will be available during the Congress.

Thursday, October 8 from 15.00 to 19.00

Friday, October 9 from 08.30 to 19.30

Saturday, October 10 from 08.30 to 19.30

Sunday, October 11 from 08.30 to 13.00

GENERAL INFORMATION

Congress VenuePalazzo dei Congressi - Fiera Internazionale della SardegnaIngresso lato C.O.N.I. (Piazza Efisio Puddu)Cagliari

Registration DeskDuring the Congress the Organizing Secretariat will respect the following timetable:

Thursday, October 8 from 14.30 to 19.30

Friday, October 9 from 08.00 to 19.30

Saturday, October 10 from 08.00 to 19.30

Sunday, October 11 from 08.00 to 17.00


On site registration fees

SINS Members € 500

Non Members € 550

Official languageThe Official Language is English. No translation is provided.

Social event

Molentargius Parc SalineFriday & Saturday, October 9 & 10, h 14.00-16.00.

Guided visit to the Molentargius Parc Saline. € 10

Molentargius is a Regional Parc located in Cagliari, regarded as one of the most important humid areas in Europe, being a unique example of ecosystem within a highly anthropic context, still an ideal habitat for several animals, included pink flamingos. The visit offers a guided sightseeing around the park in an open-bus, with several stops to watch flamingos in their natural environment, as well to visit the salt basins and the old saltworks. Visits are programmed on October 9 and 10, from 2:00 to 4:00 p.m.

Only on site registration are admitted, before Friday, October 9 at 12:00.

Congress dinner

Saturday, October 10 - Convento San Giuseppe in Cagliari.

In the unique frame of Convento San Giuseppe, at only 10 minutes driving from the city centre, we welcome you to experience the ancient tastes of Sardinian tradition, immersed in an intimate and joyful atmosphere of the central court of this historical house, where the old tools of the traditional crafts witness the everyday life of ancient knowledge.Surrounded by Mediterranean essences aromas and the suggestive gardens, you will taste, in an informal environment, the culinary specialties of Sardinia. The roasters, intriguing fire masters, will offer you the ancient flavours. The square will then become the dinner place, but with the freedom to take a seat in one of the many suggestive corners of the Convento and to enjoy the unforgettable atmosphere.Registration are admitted on site, before Friday, October 9 at 12.00

Under 35 Members SINS € 200

Under 35 Non Members € 250


BadgesAll registered participants, speakers and exhibitors are requested to display their personal badge received during the registration, in order to be admitted to the Scientific Congress sessions and to each area of the Congress venue.

LunchesLunches on October 9 and 10 are included.Only registered participants wearing badges are allowed to access to the catering area.

Certificate of AttendanceCertificates of attendance will be available for all participants at the end of the Scientific Congress.

Slide Centre – Speaker’s Ready RoomA slide centre will be available near Aula Magna.All congress rooms will be equipped with personal computer and projector. It will not be allowed to hook up personal laptops.All speakers are kindly requested to go to the Speaker’s Ready Room for uploading and preview their presentation at least 2 hours before the start of their session.

Exhibition AreaA permanent technical exhibition area will be set up respecting the Congress Schedule.

Organizing SecretariatPLS EducationalVia della Mattonaia, 17 - 50121 Firenze (FI)Tel +39 055 24621 - Fax +39 055 [email protected]

Documents

2 I NSS - Paincage · 09:00-09:45 Lecture 2 How we see and hear stuff: visual and auditory routes to understanding the material properties of objects Goodale Melvyn A. (London - Canada)