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To describe the burden of influenza • doctors visits, • hospitalizations, • sick leaves, • drug consumption
among children in France. To compare it to non influenza acute respiratory infections.
Prospective study. Follow-up of a pediatric cohort called EFG Junior, including 469 children 0-14 years old, recruited during 2009 pandemic wave, from 2nd of December 2009 to 2nd of April 2010, by 93 sentinel practitioners belonging to GROG Network (Réseau des Groupes Régionaux d’Observation de la Grippe), a sentinel influenza network active in France since 1984. Maximum inclusion rate: 9 per practitioner.
Inclusion criteriaacute respiratory infection (ARI) among children (< 15 years old) consulting a GROG practitioner who collected a nasopharyngeal swab tested by the French National Reference Center for Influenzae virusesParental signed consent. Virological methods Medium transport: Virocult®. cell culture, PCR, enzyme ImmunoAssay, hemagglutinin inhibition. Questionnaires filled by GROG sentinel doctor at D0 (swabbing day) and D14-D21 (follow-up visit). Monitoring and data managementCentralised monitoring and data management were assumed by Open Rome through a specific IT platform.
DefinitionsInfluenza positive patient: child whose specimen is positive for flu viruses. Influenza negative patient: child whose specimen is negative for flu viruses.
Severity indexlow severity: only one medical consult without home visit, neither parental work absenteeism nor school (or nursery) absenteeism ; high severity: home visit or school (nursery) absenteeism or parental work absenteeism ; with complications: 2 or more medical consults (ambulatory or at hospital).
EFG junior cohort: parts of an economical analysis of the burden of A(H1N1)pdm09 influenza among children
Cohen JM1, Mosnier A1, Daviaud I1, Bui TT1, Ruestch M2, Berche H3, Matias G4
1 Open Rome, 2 General Practitioner, Dessenheim, France, 3 General Practitioner, Compiègne, France, 4 GSK Biologicals, Wawre, Belgium
Presenting author : Jean Marie COHEN, MD, Open Rome, 67 rue du Poteau F-75018 Paris, France, EU. +331.565.55.151 Em : [email protected]
Objectives
Thanks to GROG Network, Sylvie van der Werf, Bruno Lina, Martine Valette, Vincent Enouf, Dominique Rousset.Disclosure. EFG prospective study has been funded by GSK France
Absenteeism
Study design
Methods
Preliminary Results
Drug prescriptions
0-23 months 2-4 years 5-14 years
Parental work absenteeism
Influenza Other ARI Influenza
Other ARI Influenza
Other ARI
% parents affected 21% 30% 35% 33% 46% 31%
Mean duration (days) 4,3 3,0 3,8 2,7 3,5 2,2
School absenteeismInfluenza Other
ARIInfluenza Other
ARIInfluenza Other
ARI
% children affected 21% 41% 70% 67% 76% 84%
Mean duration (days) 5,3 4,4 4,8 4,9 5,4 4,4
Proportion consulting at the emergency room (with complications)
Age groups
Influenza Other ARI
0-23 months 60 % 19 %2-4 years 13 % 7 %5 years + 4 % 3 %
Consultation at emergency rooms varies with age and the presence of influenza.
InfluenzaInfluenza
Low Low severityseverity
InfluenzaInfluenzaHigh High
severityseverity
InfluenzaInfluenzawith with
complicationscomplications
Other Other ARIARILow Low
severityseverity
Other Other ARIARIHigh High
severityseverity
Other Other ARIARIwithwith
complicationscomplications
0 - 23 months
Mean cost
with antibiotics 9,63 €* 23,67 € 24,21 € 35,82 € without antibiotics 17,20 € 16,54 € 12,15 € 6,55 € 9,24 € 30,32 € Overall 15,68 € 16,54 € 12,15 € 10,44 € 12,39 € 32,43 €
2 - 4 years
Mean cost with antibiotics 48,29 € 31,41 € 42,02 € 33,57 € 24,97 € 47,13 € without antibiotics 10,96 € 10,93 € 55,58 € 11,81 € 10,58 € 33,32 € Overall 27,26 € 12,40 € 48,20 € 18,03 € 13,77 € 36,70 €
5 - 14 years
Mean cost with antibiotics 25,38 € 33,83 € 15,17 € 17,51 € 24,55 € without antibiotics 7,65 € 24,55 € 33,91 € 13,97 € 7,66 € 22,42 € Overall 7,65 € 25,00 € 35,71 € 14,19 € 10,12 € 24,35 €
