Essential Antimicrobial & Antioxidant Feed Addetive

Economical  Reasons  

Essential  

•  Energy  Saver:  •  Decrease  up  to  100  kcal/kg  of  ME:  Keep  same  FCR  and  ADG  

•  Improve  ADG  and  FCR  • AnDmicrobial  Effect:  

•  Effects  against  gram  posiDve  bacteria:  Clostridium  perfringens  (NE).  •  Effects  against  protozoa:  Coccidiosis  

• What  are  the  energy  effects  of  reducing  NE  or  coccidiosis?  

Broilers  

•  Energy  Saver:  •  Decrease  up  to  90  kcal/kg  of  ME:  Keep  same  producDon.  •  Decrease  3  g/day  of  the  daily  intake.  

• AnDoxidant  Effect:  beRer  persistency.  • AnDmicrobial  Effects:  

•  Effects  against  gram  posiDve  bacteria:  Clostridium  perfringens  (NE).  •  Decreased  mortality.  

• What  are  the  effects  on  energy  and  aminoacids  when  the  microbial  challenge  is  reduced?  

Layers  

• AnDmicrobial  Effect:  •  Effects  against  gram  posiDve  bacteria:  Clostridium  perfringens  (NE).  •  Effects  against  protozoa:  Coccidiosis  

• AnDoxidant  Effect:  •   BeRer  persistency.  •  BeRer  hatchability.  

Broiler  Breeders  

• Natural  • No  toxic  residues  in  animal  products  • No  negaDve  interacDons  

• No  toxicity…  (maybe  this  is  client  convincing!)  

Nice…  but  not  client  convincing  

AnDmicrobial  • Protozoa  • Gram  PosiDve  

DigesDon  Enhancer  • Energy  Saver  

AnDoxidant  • BeRer  ReproducDon  • BeRer  Carcass,  Eggs  

Essential  

EssenDal  Castor  oil  

Ricinoleic  Acid  

Cashew  Nut  Shell  Liquid  (CNSL)  

Cardol   Cardanol  

Composition  of  Essential  

Natural  Divalent  Ionophore  • AcDvity  against  gram  posiDve  bacteria  • AcDvity  against  protozoa  

AnD-­‐inflammatory  • Downregulates  EP3  receptors  

Ricinoleic  Acid  

Natural  Monovalent  Ionophore  • AcDvity  against  gram  posiDve  bacteria  • AcDvity  against  protozoa  

AnDoxidant  

Cardol  

   AnDoxidant  

Cardanol  

Essential  is  conventional  &  natural  1.  Tested  levels  of  ricinoleic  acid,  cardol  and  cardanol.  

2.  Quality  control  of  the  Einal  product.  3.  Analysis  of  active  compounds  in  the  feed.  

Synergistic  Effect:  Castor  oil  +  CNSL  

EssenDal  

An#-­‐inflammatory  

An#oxidant   An#microbial  

A^er  EssenDal  

Healthy  

Reddish  

Integrity  

Antimicrobial  

Before  EssenDal  

Hemorragic  

Yellowish  

Petechia  

Effects  of  Essential  against  three  strains  of  Clostridium  perfringens  

Treatment CP 8-1 CP 8-2 CP 3-1

Control + + +

Essential - - -

(+) Bacterial growth; ( - ) No bacterial growth  

Effects  of  Essential  in  broilers  inoculated  with  E.  acervulina,  E.  maxima  and  E.  tenella  (Lara  et  al.,  2006)  

Treatment Duodenum Ileum Cecum

Neg. Control 0.00 0.00 0.00

Neg. Control Inoculated 1.11a 1.17 1.78a

Salinomicin – Inoculated 0.72b 0.72 1.61a

Essential - Inoculated 0.67b 1.20 1.13b

abMeans in the same column with different superscripts differ P < 0.05  

Intestinal  lesion  score  of  the  birds  7  d  after  a  coccidiosis  challenge  (21  d  of  age)  with  and  without  Essential  supplementation.    

a  

b  b  

a  

b  b  

abMeans with different superscripts are significantly different (P < 0.05).  

Liveability  (%)  of  the  birds  at  21  and  42  days  of  age  with  and  without  Essential  supplementation.    

3.40  2.24  SEM  

96.25  97.33b  +  2  97.08  98.00b  -  2  93.33  97.33b  +  1.5  95.83  97.00b  -  1.5  96.25  87.33a  +  0  

21 to 42 days  1 to 21 days  Liveability (%)  

Challenge  Suplementation, Essential, kg/ton  

abMeans with a different superscript letter within a column are significantly different (P < 0.05)  

Energy  Saver  

Nutrient  extracDon   Economic  Benefit  

BeRer  DigesDon  

BeRer  AbsorpDon  

Miroflora  Improvement  

IntesDnal  mucosa  

protecDon  

Enzyme  acDvity  

sDmulaDon  

Energy  extracDon  

IntesDnal  Integrity  

Feed conversion (g of feed/g of gain) for the birds with and without Essential supplementation at 7 and 14 d of age (pre-challenge)  

a  

b   b  

c  

c  d   d  

d   d  

abTreatments differ (P = 0.0001) cdTreatments differ (P < 0.02)  

Treatment Weight @ 42 d, kg Intake, kg FCR FCR @ 2.5 kg Control-0 3.093a 5.120a 1.682ab 1.512a

Essential-0 3.207b 5.206ab 1.648ab 1.446b Control-100 3.046a 5.198a 1.734c 1.578c

Essential-100 3.182b 5.269bc 1.681ab 1.487ab Control-200 2.968c 5.260bc 1.801d 1.667d

Essential-200 3.066a 5.322c 1.763ce 1.601ce Essentialgf-100 3.160b 5.260bc 1.690b 1.502a Essentialgf-200 3.018ac 5.301bc 1.785de 1.637de Essentialf-100 3.054a 5.200a 1.731c 1.572c Essentialf-200 2.971c 5.262bc 1.800d 1.666d

Effects of Essential on diets with different levels of energy  

y = 0.0074x + 0.1843

y = 0.0065x + 0.5185

y = 0.008x + 0.0307

y = 0.007x + 0.4353

2.85

2.90

2.95

3.00

3.05

3.10

3.15

3.20

3.25

3.30

355 360 365 370 375 380 385 390 395 400 405 410

Wei

ght G

ain,

kg

EM, kcal/d

Control 35-42 d 21-42 d Essential Linear (Control) Linear (35-42 d) Linear (21-42 d) Linear (Essential)

Effects  of  Essential  on  ME  

Effect  of  Dietary  Supplementation  of  Essential®  and  Pharmaceuticals  on  Breast  Meat  Drip  Loss  

P<0.10  

Effect of Dietary Supplementation of Essential® and Pharmaceuticals on TBARS values  

*Means  differ  P  <  0.02  

Essential  -­‐  Layers  

Test  Protocol-­‐I  ProducDon  under  heat  stress  

Strain:  Bovans  White  

Ages:  23  weeks  

Number  of  birds:  

 2.957  with  EssenDal  (1.5  kg/MT)  

 17.667  Control  

Weekly  Production  under  heat  stress  

Weekly  average  Week   Essen.al   Control  23   58,8   61,4  24   65,6   65,5  25   76,7   70,8  26   86,4   74,3  27   86,9   76,7  28   87,0   72,4  29   85,3   73,2  30   82,6   72,8  31   86,9   74,8  32   82,2   76,4  

Average   79,84   71,83  

Daily  Production  

50.0  

55.0  

60.0  

65.0  

70.0  

75.0  

80.0  

85.0  

90.0  

95.0  

1   3   5   7   9   11   13   15   17   19   21   23   25   27   29   31   33   35   37   39   41   43   45   47   49   51   53   55   57   59   61   63   65   67   69  

ESSENTIAL   PADRÃO  

Weekly  Production  

58.8  

65.6  

76.7  

86.4   86.9   87  85.3  

82.6  

86.9  

82.2  

79.84  

61.4  

65.5  

70.8  

74.3  

76.7  

72.4   73.2   72.8  74.8  

76.4  

71.83  

40  

45  

50  

55  

60  

65  

70  

75  

80  

85  

90  

23   24   25   26   27   28   29   30   31   32   média  

%  Produ

c#on

Weeks  

EssenDal   Padrão  

Conclusão  

•  The  group  supplemented  with  EssenDal  showed  beRer  producDon  than  the  control  

Test  Protocol  -­‐  II  Strain:  Hy-­‐Line    

Age:  56  weeks  

Number  of  birds:  

 17.767  –  White    

 4.437  –  Red  

Dosage:  1.5  kg/MT  

Production  Data  

Week  Produc#on  Standard   Produc#on   %  produc#on   Mortality  %  

55   83   77,4   -­‐5,6   0,144  

56   82   76,9   -­‐5,1   0,302  

57   82   83,4   1,4   0,379  

58   81   79,4   -­‐1,6   0,390  

59   81   79,6   -­‐1,4   0,146  

60   81   80,7   -­‐0,3   0,269  

61   80   78,2   -­‐1,8   0,200  

Production  &  Mortality  

77.4   76.9  

83.4  

79.4   79.6  80.7  

78.2  

0.144  

0.302  

0.379   0.390  

0.146  

0.269  0.200  

0.000  

0.050  

0.100  

0.150  

0.200  

0.250  

0.300  

0.350  

0.400  

0.450  

50.0  

55.0  

60.0  

65.0  

70.0  

75.0  

80.0  

85.0  

90.0  

95.0  

100.0  

55   56   57   58   59   60   61  

Produção   mortalidade  %  

Beginning of Essential Supplementation

End of Essential Supplementation

Pictures  of  1st  necropsy  (09/09/2011)  

1st  necropsy  

1st  necropsy  

Pictures  of  2nd  necropsy  (30/09/2011)  

2nd  necropsy  

2nd  necropsy  

Piictures  of  3rd  necropsy  (12/10/2011)  

3rd  necropsy    

3rd  necropsy    

Conclusion  •  The  birds  were  already  post-­‐peak  and  below  the  standard  curve  when  the  treatment  began.    

• During  the  treatment  there  was  an  improvement  in  the  laying  %.  •  In  week  61,  a^er  ending  the  supplementaDon  of  EssenDal,  the  producDon  fell.  

• Mortality  was  50%  lower  a^er  EssenDal  supplemenDon  compared  to  the  rest  of  the  farm.  

Effects  of  Essential  supplementation  on  broiler  breeder  performance  (Brazil)  

AnDmicrobial  • Protozoa  • Gram  PosiDve  

DigesDon  Enhancer  • Energy  Saver  

AnDoxidant  • BeRer  ReproducDon  • BeRer  Carcass,  Eggs  

Essential