Embase: Adverse Drug Reactions - webinar September 25 2013

Embase® is a registered trademark of Elsevier BV.

SEARCHING FOR ADVERSE EVENTS ON

EMBASE

Presented by Ian Crowlesmith

25 September 2013i.crowlesmith@elsevier.com

Your host:Ann-Marie Roche

• Webinar control panel:

• ‘chat’ for questions or ‘ask aquestion’

• minimize option for full screen view

• Q&A halfway and last 10-15 minutes of the webinar

NEED TO KNOW

AGENDA

Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase

1. Embase vs MEDLINE2. Adverse reactions on

Embase3. Searching side effects4. Using keywords5. Adverse events of devices

SEARCHING FOR ADVERSE EVENTS ON EMBASE

Embase3. Searching side effects4. Using keywords5. Adverse events of devices

DEFINITIONS OF ADVERSE EVENTS

ON EMBASE AND MEDLINE

Embase

PubMed / MEDLINEfirst 4 of >100 terms

"chemicals and drugs category/adverse effects"[MeSH Terms] NOT ("chemicals and drugs category/toxicity"[MeSH Terms] OR "chemicals and drugs category/poisoning"[MeSH Terms])

Search using:

Search using: "chemicals and drugs”/exp/dd_ae

only in humans

ADVERSE DRUG REACTIONS REPORTED BY FDA

US AND NON-US ORIGIN (2003-2011)

http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Surveillance/AdverseDrugEffects/ucm070441.htm

ADVERSE DRUG REACTIONS: EMBASE VS MEDLINE

BASED ON SUBHEADINGS LINKED TO “CHEMICALS AND DRUGS”

1990 1995 2000 2005 20100

10,000

20,000

30,000

40,000

50,000

Embase

MEDLINE

Publication year

Recordsper year Embase includes all of

MEDLINE

Subheadings introduced in Embase (1988)

Search strategy for Embase: "chemicals and drugs”/exp/dd_ae

Embase3. Searching for side effects4. Using keywords5. Adverse events of devices

ADVERSE REACTIONS IN EMBASE

BROWSING EMTREE TO FIND DRUG NAMES

DRUG SEARCH

FILTERED TO LIST INDEXED DRUGS

ADVERSE REACTIONS TO CISPLATIN

FILTERED TO LIST INDEXED DISEASES

IN-DEPTH DRUG INDEXING

EMBASE VS MEDLINE

Embase

OTHER ADVERSE EVENTS IN EMBASE

DRUG TOXICITY (SCOPE NOTE)

ADVERSE EVENTS IN EMBASE

DRUG TOXICITY VS ADVERSE DRUG REACTION

ADVERSE EVENTS IN EMBASE

ADDITIONAL SEARCH OPTIONS

This is a conference abstract

This is an In-Process record

Embase3. Searching for side

effects4. Using keywords5. Adverse events of devices

SIDE EFFECTS IN EMTREE

first 12 of over 100 terms

SEARCHING SIDE EFFECTS ON EMBASE

DISEASE SEARCH

SEARCHING SIDE EFFECTS ON EMBASE

FILTER TO LIST INDEXED DISEASES

INDEXING OF SIDE EFFECTS ON EMBASE

SIDE EFFECTS OF CISPLATIN

Embase3. Searching for side effects4. Using keywords5. Adverse events of devices

SEARCHING ADVERSE EVENTS USING KEYWORDS

“ADVERSE” AS A KEYWORD

KEYWORDS FOR SEARCHING ADVERSE EVENTS

REPRESENTATIVE KEYWORDS

SEARCHING ADVERSE EVENTS USING KEYWORDS

UNIQUE RECORDS RETRIEVED FOR CISPLATIN

This is an In-Process record

Outside AE definition for both Embase & MEDLINE

Embase3. Searching for side effects4. Using keywords5. Adverse events of

devices

ADVERSE EVENTS FOR MEDICAL DEVICES

REPORTED BY FDA (2004-2008)

http://clinicaldevice.typepad.com/cdg_e_conferences/adverse-events-and-effects/

MEDICAL DEVICES ON EMTREE

NEW TREE STRUCTURE (2013)

FINDING ADVERSE EVENTS FOR MEDICAL DEVICES

DISEASE SUBHEADING “COMPLICATION”

SEARCHING FOR ADVERSE EVENTS ON DEVICES

USING DISEASE SUBHEADING “COMPLICATION”

RECORDS RETRIEVED USING KEYWORDS

TYPICAL RECORD FOUND USING KEYWORDS

This record is a conference abstract !

SUMMARY

Keyword searches

• Use keywords saved in ‘hedges’ (saved searches) or alerts.

• Useful for Articles-in-Press, In-Process & Conference records.

• This will increase sensitivity at the cost of precision.

Medical devices

• Search adverse effects using disease subheading CO.

• Also consider expanding search using keywords.

• Over 3000 medical devices are now available in Emtree.

Adverse drug reactions

• Use drug subheading AE where possible. Focus is on human.

• Consider expanding search using keywords.

• This will increase sensitivity at the cost of precision.

THANK YOU ANY

QUESTIONS?

Ian Crowlesmith

Senior Product Manager, Content Development

i.crowlesmith@elsevier.com

36Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase

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Our next Embase webinar is on October 23 and this will be an introduction to Embase for new users.

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Embase: Adverse Drug Reactions - webinar September 25 2013

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