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7/25/2019 Presentasi Journal Reading + patof , Frisca F Agan
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The Role of Vitamin D in
Children with RecurrentTonsillopharyngitis
Canan Cacina
Sadk Toprak
Ayse Kilic
Salih Aydin
Frisca Finlania Agan !"#$!!%!!#%&em'im'ing( dr) *) Agus+ Sp)T,T+ *)Kes
Yildiz et al. Italian Journal of Pediatrics 2012, 38:25
http://.i!ponline.net/content/38/1/25
-smail .ildi/
0min 1nu2ar1mit 3ey'ek4ahar Toptas
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I"#$%&'(#I%"
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#%")I*%P+$Y"-I#I)
#onsillopharnitis : acute infection of
tonsil and pharn, characterized
erthea, eudation, ulceration or
erane.
tiolo : 4irus and -roup eta6
haeoltic streptococci
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$ecurrent tonsillopharnitis :
7 episodes of tonsillopharnitis in
a ear %$7 5 episodes of acute tonsillitis in a
ear for to conse9uetie ears %$
7 3 episodes of acute tonsillitis in aear for three conse9uetie ears
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$is; factors : #he enironental
conditions, the child
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Pathophsiolo
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4I#=I" &
4itain & has a preentie role for inhiition
of acterial iofil
$ole of itain & : aintainin of innate
iunitdendritic cells, lphoctes, #lphoctes, "> cells
4itain & receptors ?4&$@ in an tissues
Ao; I, s, pa and #a9 polorphissdescried reardin 4&$ ene affected
itain &.
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4itain & =etaolis
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P'$P%)
to deterine the role of the
polorphis characteristics of
itain & and 4&$ receptors in
children dianosed ith recurrent
tonsillopharnitis.
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*AT0R-A5 A6D *0T,7DS
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)tud desin
=etode : retrospectie stud
2B2 children eteen 2 and 10 ears
of ae Perfored in Istanul 'niersit,
Istanul =edical Aacult, &epartent
of Pediatrics, %utpatient (linic of
-eneral Pediatrics
eteen pril 2008 and pril 200C.
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the total nuer of access to the
outpatient clinic as 58C33
B,D ?280@
acute tonsillopharitis 115/280 ?B,1D@ et the eliililit
criteria
12
control roup
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(onducted ostl in autun and inter
seasons ecause of the increased fre9uenc
of tonsillopharnitis durin those seasons
and seasonal ariailit of the itain & leels lood saples ere collected fro oth
roups and ere studied in the sae season.
)eru 25?%+@ itain & and 1,256?%+@2itain & leels ere easured *I)
ethod
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Aiure 1 Alo chart of the stud.pril 1st, 2008 E pril 1st, 200C
"uer of isits to the outpatient clinic?58C33@
"uer of cases dianosed ith acute tonsillopharnitis
?280@
"uer of cases included to the stud
?155@
12 of CF E *I) ;it ere
used durin the preparation
phase
&" could not isolated fro 15
saples in #a9 and pa
polorphiss and 1B saples
in Ao; 1 polorphis
"uer of cases
ith easured
)eru 25?%+@
itain & leel8B ?3D@
"uer of cases
ith easured
)eru 1,25?%+@2
itain & leel8B ?3D@
"uer of cases ith studied
4&$ ene polorphisG
#a9 polorphis 100 ?D8F,C@
pa polorphis 100 ?D8F,C@Ao; 1 polorphis 101 ?D8,8@
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#he liiilit (riteria Aor Participants
Inclusion criteria for the stud roup:
a@ +ain tonsillopharnitis H ties a ear,
@ +ain sptos of tonsillopharnitis
deeloped ithin last das,
c@ "o conditions re9uirin to e hospitalized,
d@ -ien parental consent,
e@ "o ;non chronic diseases,f @ "ot hain an suppleentation of itain
& durin the last 3 onth.
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#onsillopharnitis
&ianosed : phsical eaination perfored aphsician and su!ects included to the the stud
reardless of the etiolo
#he su!ects : dianosed as tonsillopharnitis
ore than ties in a ear are considered asfre9uent tonsillopharnitis. #he fre9uenc :
inestiated reiein the hospital records and
referrin the feedac; of parents if the patient
is dianosed ith tonsillopharnitis in a differentinstitution or a prescription for tonsillopharnitis
as ien another phsician preiousl.
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=easureent of seru itain & leel and
deterination of itain & receptor ?4&$@ ene
polorphis
)tud seru 25?%+@ and 1,256?%+@ itain &
leels ere easured sandich nze
*in;ed Iunosorent ssa ?*I)@
ethod &" of the su!ects as isolated fro the
lood saples otained and 4&$
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Interpretation of seru itain & leels
)eru 25?%+@ itain & leel as interpreted :
Insufficient : 50E80 nol/*
)ufficient :80E250 nol/*
cess :250E325 nol/* Intoication : H 325 nol
)eru 25?%+@ itain & leel
pperent deficienc : 50 nol/*
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Aactors affectin seru itain & leel
&ail eposure to sunliht
-ender
e
Keiht
#he aount of tie spent ith outdoor
actiities and at seaside
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thical coittee approal and support
Istanul 'niersit, Istanul )chool of
=edicine ethical coittee approal as
ta;en in Januar 2008 ith the file
nuered 2008/35 efore the stud asperfored.
#his stud as supported Istanul
'niersit )cientific $esearch Pro!ects
?Pro!ect "o: 200F@.
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)tatistical analsis
)tudent
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$)'*#)
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&I)('))I%"
#he eistence of 4&$s in iune sste cells a
#he est paraeter for the ealuation of itain & :
- od itain & storae : seru 25 ?%+@ itain &
leels ?half life : 20 das@- ioloicall actie for : 1,256?%+@2 itain & ?half
life : 3 to F hours@, circulatin lood leel is er lo
)eru 25?%+@ itain & and 1,256?%+@2 itain &
leels ere easured *I) ethod
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erae seru 256?%+@ itain & leels
ere in the noral rane in oth roups, it
as sinificantl loer in the children ith
fre9uent tonsillopharnitis ?p 0.01@ #o randoized controlled trails reported
that, itain & suppleentation is effectie
for preention of upper respirator tract
infections
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din and colleaues prospectie
research seru 256?%+@ itain &
leels in tonsillecto patients ith
recurrent tonsillitis N no statistical
differencesith the control roup.
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(%"(*')I%"
*o seru itain & leel can e a ris; factor for
recurrent tonsillopharnitis.
In children hain recurrent tonsillopharnitis,
seru 25?%+@ itain leels ere loer thanthose of health children.
"o difference in itain & receptor ene
polorphis.
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In the future,
iin itain & support to the children ithrecurrent tonsillopharnitis, then
easurin their seru itain & leels and
oserin the decrease in annual disease
fre9uenc after the supportie treatentould eactl eplain the relation eteen
itain & and hain recurrent
tonsillopharnitis.
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T,A6K .71
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