Non-Sporeforming Anaerobes Stains gram-variable or gram-negative, but not a gram-negative cell wall

Non-Sporeforming Anaerobes

Non-Sporeforming Anaerobes

Stains gram-variable or gram-negative, but not a gram-negative cell wall

Non-Sporeforming Anaerobes (cont.)

Most Common Sites of Anaerobic

Infection

Characteristics of Anaerobic Infection

Characteristic Clinical Signs of Anaerobic Infection

Anaerobic Gram-Positive Non-Sporeforming Bacterial Infections

Gram-Positive Non-sporeforming

Anaerobes

NOTE: Figure legend in text indicates that each of these organisms is a bacillus (i.e., rod-shaped). This is INCORRECT. Peptostreptococcus is, as the name indicates, a coccus.

Diseases Associated with Anaerobic Gram-Positive Bacilli

Gram Stain and Macroscopic Colonies of Actinomyces

NOTE: Molar tooth appearance of colonies on agar can help remind us that the oral cavity is a common niche for Actinomyces.

Actinomyces Infections

Cervicofacial Actinomycosis

NOTE: Sinus tract originating in oral cavity has made it’s way to the surface at the jawline.

Colonized IUD Resulting in Pelvic Actinomycosis

Epidemiology of

Actinomycosis

Sulfur Granule from Sinus Tract of Actinomycotic Infection

Epidemiology of Propionibacterium

(doxycycline)

Anaerobic Gram-Negative Non-Sporeforming Bacterial Infections

Anaerobic Gram-Negative Infections

Anaerobic Gram-Negative Infections (cont.)

Clinically Predominant Anaerobic Gram-Negatives

Broad Classes of Virulence Factors Associated with Gram-Neg. Anaerobes

Adhesins

Protection from:

• Oxygen toxicity

• Phagocytosis

Tissue Destruction

Anaerobic Gram-Neg. Virulence Factors

Anaerobic Gram-Negative Virulence Factors (cont.)

Epidemiology of Bacteroides

Bacteroides Gram Stain

Bacteroides Virulence Factors

[1]

[5]

[3]

[4]

[2]

[6]

[8]

[7]SUBUNIT

SUBUNIT

DEAD

LIVE

LIVE

MIXED+

+MIXED

MIXED

Bacteroides Pathogenicity

REVIEWNon-Sporeforming Anaerobes

Characteristics of Anaerobic Infection

REVIEW

Characteristic Clinical Signs of Anaerobic Infection

REVIEW

Most Common Sites of Anaerobic

Infection

REVIEW

Review of Anaerobic Gram-Positive

Non-Sporeforming Bacterial Infections

REVIEW

Gram-Positive Non-sporeforming

Anaerobes

REVIEW

Actinomyces Infections

REVIEW

Epidemiology of

Actinomycosis

REVIEW

Epidemiology of Propionibacterium

(doxycycline)

REVIEW

Review of Anaerobic Gram-Negative

Non-Sporeforming Bacterial Infections

REVIEW

Anaerobic Gram-Negative Infections

REVIEW

Anaerobic Gram-Negative Infections (cont.)

REVIEW

Clinically Predominant Anaerobic Gram-Negatives

REVIEW

Broad Classes of Virulence Factors Associated with Gram-Neg. Anaerobes

Adhesins

Protection from:

• Oxygen toxicity

• Phagocytosis

Tissue Destruction

REVIEW

Anaerobic Gram-Neg. Virulence Factors

REVIEW

Anaerobic Gram-Negative Virulence Factors (cont.)

REVIEW

Epidemiology of Bacteroides

REVIEW

Bacteroides Virulence Factors

REVIEW

[1]

[5]

[3]

[4]

[2]

[6]

[8]

[7]SUBUNIT

SUBUNIT

DEAD

LIVE

LIVE

MIXED+

+MIXED

MIXED

Bacteroides Pathogenicity

REVIEW