Embed Size (px)
Citation preview
Non-Sporeforming Anaerobes
Non-Sporeforming Anaerobes
Stains gram-variable or gram-negative, but not a gram-negative cell wall
Non-Sporeforming Anaerobes (cont.)
Most Common Sites of Anaerobic
Infection
Characteristics of Anaerobic Infection
Characteristic Clinical Signs of Anaerobic Infection
Anaerobic Gram-Positive Non-Sporeforming Bacterial Infections
Gram-Positive Non-sporeforming
Anaerobes
NOTE: Figure legend in text indicates that each of these organisms is a bacillus (i.e., rod-shaped). This is INCORRECT. Peptostreptococcus is, as the name indicates, a coccus.
Diseases Associated with Anaerobic Gram-Positive Bacilli
Gram Stain and Macroscopic Colonies of Actinomyces
NOTE: Molar tooth appearance of colonies on agar can help remind us that the oral cavity is a common niche for Actinomyces.
Actinomyces Infections
Cervicofacial Actinomycosis
NOTE: Sinus tract originating in oral cavity has made it’s way to the surface at the jawline.
Colonized IUD Resulting in Pelvic Actinomycosis
Epidemiology of
Actinomycosis
Sulfur Granule from Sinus Tract of Actinomycotic Infection
Epidemiology of Propionibacterium
(doxycycline)
Anaerobic Gram-Negative Non-Sporeforming Bacterial Infections
Anaerobic Gram-Negative Infections
Anaerobic Gram-Negative Infections (cont.)
Clinically Predominant Anaerobic Gram-Negatives
Broad Classes of Virulence Factors Associated with Gram-Neg. Anaerobes
Adhesins
Protection from:
• Oxygen toxicity
• Phagocytosis
Tissue Destruction
Anaerobic Gram-Neg. Virulence Factors
Anaerobic Gram-Negative Virulence Factors (cont.)
Epidemiology of Bacteroides
Bacteroides Gram Stain
Bacteroides Virulence Factors
[1]
[5]
[3]
[4]
[2]
[6]
[8]
[7]SUBUNIT
SUBUNIT
DEAD
LIVE
LIVE
MIXED+
+MIXED
MIXED
Bacteroides Pathogenicity
REVIEWNon-Sporeforming Anaerobes
Characteristics of Anaerobic Infection
REVIEW
Characteristic Clinical Signs of Anaerobic Infection
REVIEW
Most Common Sites of Anaerobic
Infection
REVIEW
Review of Anaerobic Gram-Positive
Non-Sporeforming Bacterial Infections
REVIEW
Gram-Positive Non-sporeforming
Anaerobes
REVIEW
Actinomyces Infections
REVIEW
Epidemiology of
Actinomycosis
REVIEW
Epidemiology of Propionibacterium
(doxycycline)
REVIEW
Review of Anaerobic Gram-Negative
Non-Sporeforming Bacterial Infections
REVIEW
Anaerobic Gram-Negative Infections
REVIEW
Anaerobic Gram-Negative Infections (cont.)
REVIEW
Clinically Predominant Anaerobic Gram-Negatives
REVIEW
Broad Classes of Virulence Factors Associated with Gram-Neg. Anaerobes
Adhesins
Protection from:
• Oxygen toxicity
• Phagocytosis
Tissue Destruction
REVIEW
Anaerobic Gram-Neg. Virulence Factors
REVIEW
Anaerobic Gram-Negative Virulence Factors (cont.)
REVIEW
Epidemiology of Bacteroides
REVIEW
Bacteroides Virulence Factors
REVIEW
[1]
[5]
[3]
[4]
[2]
[6]
[8]
[7]SUBUNIT
SUBUNIT
DEAD
LIVE
LIVE
MIXED+
+MIXED
MIXED
Bacteroides Pathogenicity
REVIEW
