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4/3/13
1
Mechanics of Cell Division
László Grama 2 April, 2013
The Cell Cycle
Alberts. Molecular Biology of the Cell. 4th Edition
4/3/13
2
Cytoskeletal Machines Perform Both Mitosis and Cytokinesis
Alberts. Molecular Biology of the Cell. 4th Edition
M Phase in Animal Cells Depends on Centrosome Duplication in the
Preceding Interphase
Alberts. Molecular Biology of the Cell. 4th Edition
4/3/13
3
M Phase in Animal Cells Depends on Centrosome Duplication in the Preceding Interphase
Alberts. Molecular Biology of the Cell. 4th Edition
M Phase Is Traditionally Divided into Six Stages A
lber
ts. M
olec
ular
Bio
logy
of t
he C
ell.
4th E
ditio
n
4/3/13
4
Three Classes of Spindle Microtubules
Microtubule Instability Increases Greatly at M Phase
Alberts. Molecular Biology of the Cell. 4th Edition
4/3/13
5
Interactions Between Opposing Motor Proteins and Microtubules of Opposite Polarity Drive Spindle
Assembly
Alberts. Molecular Biology of the Cell. 4th Edition
Kinetochores Attach Chromosomes to the Mitotic Spindle
Alberts. Molecular Biology of the Cell. 4th Edition
4/3/13
6
Microtubules Are Highly Dynamic in the
Metaphase Spindle
Alberts. Molecular Biology of the Cell. 4th Edition
Opposing forces may drive chromosomes to the metaphase plate
Alberts. Molecular Biology of the Cell. 4th Edition
4/3/13
7
Sister Chromatids Separate Suddenly at Anaphase
Alberts. Molecular Biology of the Cell. 4th Edition
Kinetochore Microtubules Disassemble at Both Ends During Anaphase A
Alberts. Molecular Biology of the Cell. 4th Edition
4/3/13
8
Both Pushing and Pulling Forces Contribute to Anaphase B
Alberts. Molecular Biology of the Cell. 4th Edition
Actin and Myosin II in the Contractile Ring Generate the Force for Cytokinesis
Alberts. Molecular Biology of the Cell. 4th Edition
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