Biomedical R&D Folie (slide) 1 Saratin - mechanism of action vWF Platelet

Preview:

Citation preview

Biomedical R&D

Folie (slide) 1

Saratin - mechanism of action

vWF

Platelet

Biomedical R&D

Folie (slide) 2

Saratin - mechanism of action

vWF

Platelet

Biomedical R&D

Folie (slide) 3

Saratin - mechanism of action

Platelet

vWF

Biomedical R&D

Folie (slide) 4

Saratin - mechanism of action

vWF

Platelet

Biomedical R&D

Folie (slide) 5

Saratin - mechanism of action

Platelet

vWF

Biomedical R&D

Folie (slide) 6

Saratin - mechanism of action

vWF

Platelet

Biomedical R&D

Folie (slide) 7

Saratin - mechanism of action

Platelet

vWF

Biomedical R&D

Folie (slide) 8

Saratin - mechanism of action

Platelet

Biomedical R&D

Folie (slide) 9

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 10

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 11

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 12

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 13

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 14

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 15

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 16

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 17

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 18

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 19

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 20

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 21

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 22

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 23

Saratin - mechanism of action

Vessel wall injury exposes collagen to elements of flowing blood.

Biomedical R&D

Folie (slide) 24

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 25

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 26

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 27

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 28

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 29

Saratin - mechanism of action

vWF A3 domain binds to collagen.

Biomedical R&D

Folie (slide) 30

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 31

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 32

Saratin - mechanism of action

vWF A1 domain targets GP Ib/IX/V receptor of circulating platelets, “tethering” them to the vessel wall.

Biomedical R&D

Folie (slide) 33

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 34

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 35

Saratin - mechanism of action

Direct collagen-platelet interactions (GP Ia/IIa, GP VI etc.) anchor and then lead to activation of the tethered platelet.

Biomedical R&D

Folie (slide) 36

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 37

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 38

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 39

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 40

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 41

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 42

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 43

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 44

Saratin - mechanism of action

Occlusivethrombus!

Biomedical R&D

Folie (slide) 45

Saratin - mechanism of action

How does saratin interfere with arterial thrombosis?

Biomedical R&D

Folie (slide) 46

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 47

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 48

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 49

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 50

Saratin - mechanism of action

Biomedical R&D

Folie (slide) 51

Saratin - mechanism of action

S

Biomedical R&D

Folie (slide) 52

Saratin - mechanism of action

SS

Biomedical R&D

Folie (slide) 53

Saratin - mechanism of action

SSS

Biomedical R&D

Folie (slide) 54

Saratin - mechanism of action

S

Saratin binds to collagen, preventing interaction with vWF and hence platelets.

SSS

Biomedical R&D

Folie (slide) 55

Saratin - mechanism of action

SSSS

Biomedical R&D

Folie (slide) 56

Saratin - mechanism of action

SSSS

Biomedical R&D

Folie (slide) 57

Saratin - mechanism of action

SSSS

Biomedical R&D

Folie (slide) 58

Saratin - mechanism of action

SSSS

Biomedical R&D

Folie (slide) 59

Saratin - mechanism of action

SSSS

Biomedical R&D

Folie (slide) 60

Saratin - mechanism of action

SSSS

Biomedical R&D

Folie (slide) 61

Saratin - mechanism of action

SSSS

Biomedical R&D

Folie (slide) 62

Saratin - mechanism of action

SSSS

Biomedical R&D

Folie (slide) 63

Saratin - mechanism of action

Saratin acts as a molecular plaster, neutralising platelets BEFORE they adhere and become activated.

SSSS

Recommended