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Biomedical R&D
Folie (slide) 1
Saratin - mechanism of action
vWF
Platelet
Biomedical R&D
Folie (slide) 2
Saratin - mechanism of action
vWF
Platelet
Biomedical R&D
Folie (slide) 3
Saratin - mechanism of action
Platelet
vWF
Biomedical R&D
Folie (slide) 4
Saratin - mechanism of action
vWF
Platelet
Biomedical R&D
Folie (slide) 5
Saratin - mechanism of action
Platelet
vWF
Biomedical R&D
Folie (slide) 6
Saratin - mechanism of action
vWF
Platelet
Biomedical R&D
Folie (slide) 7
Saratin - mechanism of action
Platelet
vWF
Biomedical R&D
Folie (slide) 8
Saratin - mechanism of action
Platelet
Biomedical R&D
Folie (slide) 9
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 10
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 11
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 12
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 13
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 14
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 15
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 16
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 17
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 18
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 19
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 20
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 21
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 22
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 23
Saratin - mechanism of action
Vessel wall injury exposes collagen to elements of flowing blood.
Biomedical R&D
Folie (slide) 24
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 25
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 26
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 27
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 28
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 29
Saratin - mechanism of action
vWF A3 domain binds to collagen.
Biomedical R&D
Folie (slide) 30
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 31
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 32
Saratin - mechanism of action
vWF A1 domain targets GP Ib/IX/V receptor of circulating platelets, “tethering” them to the vessel wall.
Biomedical R&D
Folie (slide) 33
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 34
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 35
Saratin - mechanism of action
Direct collagen-platelet interactions (GP Ia/IIa, GP VI etc.) anchor and then lead to activation of the tethered platelet.
Biomedical R&D
Folie (slide) 36
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 37
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 38
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 39
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 40
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 41
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 42
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 43
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 44
Saratin - mechanism of action
Occlusivethrombus!
Biomedical R&D
Folie (slide) 45
Saratin - mechanism of action
How does saratin interfere with arterial thrombosis?
Biomedical R&D
Folie (slide) 46
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 47
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 48
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 49
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 50
Saratin - mechanism of action
Biomedical R&D
Folie (slide) 51
Saratin - mechanism of action
S
Biomedical R&D
Folie (slide) 52
Saratin - mechanism of action
SS
Biomedical R&D
Folie (slide) 53
Saratin - mechanism of action
SSS
Biomedical R&D
Folie (slide) 54
Saratin - mechanism of action
S
Saratin binds to collagen, preventing interaction with vWF and hence platelets.
SSS
Biomedical R&D
Folie (slide) 55
Saratin - mechanism of action
SSSS
Biomedical R&D
Folie (slide) 56
Saratin - mechanism of action
SSSS
Biomedical R&D
Folie (slide) 57
Saratin - mechanism of action
SSSS
Biomedical R&D
Folie (slide) 58
Saratin - mechanism of action
SSSS
Biomedical R&D
Folie (slide) 59
Saratin - mechanism of action
SSSS
Biomedical R&D
Folie (slide) 60
Saratin - mechanism of action
SSSS
Biomedical R&D
Folie (slide) 61
Saratin - mechanism of action
SSSS
Biomedical R&D
Folie (slide) 62
Saratin - mechanism of action
SSSS
Biomedical R&D
Folie (slide) 63
Saratin - mechanism of action
Saratin acts as a molecular plaster, neutralising platelets BEFORE they adhere and become activated.
SSSS
