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Pumps and Pipes:Medical Imaging
King Li, MD, FRCP(C), MBAM D Anderson Distinguished Chair, Department of Radiology
The Methodist Hospital, Houston, TX
Professor of Radiology, Weill Medical College of Cornell University
Beginning of Medical Imaging
Copyright © 2000 by National Academy of Engineering. All rights reserved. Contact Us
1. Electrification2. Automobile3. Airplane4. Water Supply and Distribution
5. Electronics6. Radio and Television7. Agricultural Mechanization8. Computers9. Telephone10. Air Conditioningand Refrigeration
11. Highways12. Spacecraft13. Internet14. Imaging15. Household Appliances
16. Health Technologies
17. Petroleum andPetrochemical Technologies
18. Laser and Fiber Optics
19. Nuclear Technologies
20. High-performance Materials
Greatest Engineering Achievements of the 20th Century
Positron Emission Tomography Interventional Radiology
Computed Axial Tomography Ultrasonography
Magnetic Resonance ImagingDigital Radiography and Angiography
Modern Medical Imaging
Imaging: The Virtual Fantastic Voyage
Jain RK,Carmeliet PF.Sci Am 2001;285:38-45.
Computational Fluid Dyanamics
Longitudinal Study of Tumor Growth
Tumor growth
2 years
0.5
0.5
0.5
0.5
Data courtesy: fBIRN, Stanford-Lucas Center and Harvard-MGH Martino Center
Functional Neuroimaging
Kantarci et al., in press, Nature Genetics, 2007
Mutations in megalin, a multi-ligand receptor, cause Donnai-Barrow/ FacioOculoAcousticoRenal (DBS/FOAR) syndrome
Multi-scale Neurological Profiling
Imaging Probes
Weissleder R. Nature Reviews/Cancer 2002;2:1-8
Interventional Medicine of the Future:One Seamless Integrated Iterative Platform
Targeted Treatment Plan
Navigation
Visualization
Robotic needle placement
Feedback loop
MonitoringCompare to pre-tx plan
Feedback loop
Treatment PlanUpdate
•30 cycles
•On: 90 msec
•Off: 1910 msec
•Power: 20.5 Watts/cm2
•150 cycles
•On: 90 msec
•Off: 1910 msec
•Power: 20.5 Watts/cm2
Control Treated
Control TreatedYuh EL, et al. Radiology 2005;234:431-7.
Identify Targets
Drug DeliveryIn vivo drug delivery
Drug DeliveryIn vivo drug delivery
BiochemistryCulture assays, kinetic models
BiochemistryCulture assays, kinetic models
Computing / Database & Biostatistics
3D models
Computing / Database & Biostatistics
3D models
GenomicsProteomics
GenomicsProteomics
ChemistryChemical probes and reagents
ChemistryChemical probes and reagents
Molecular BiologyMolecular Biology
ImmunologyFACS analysis
ImmunologyFACS analysis
BiochemistryHistopathology
BiochemistryHistopathology
GenomicsProteomics
GenomicsProteomics
Computing / Database & Biostatistics
Data management and analysis
Computing / Database & Biostatistics
Data management and analysis
Molecular BiologyReporter constructs
Molecular BiologyReporter constructs ImagingImaging Engineering
Hardware/software
EngineeringHardware/software
EngineeringHardware/software
EngineeringHardware/software
New diagnostic and therapeutic methods
Li KC. Acad Radiol 2002;9:999-1003.