PROTEINS:STRUCTURE & FUNCTION

Ana Maria Higuita RendónMolecular Biology

UPB Medicine2011

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INTRODUCTION

Proteins are biomolecules of great importance, they can perform many functions in organism.

Can stimulate a response of an organism and functionality of a complete organism.

So if any of these proteins ir poorly structured, the function is affected.

Measles Viral Protein Movement Described ScienceDaily (Jan. 10, 2011)

Measles is a viral disease of the human reservoir, caused by the measles virus, Paramyxoviridae family, Morbillivirus gender.

Measles Virus, TEM

Measles Viral Protein Movement Described ScienceDaily (Jan. 10, 2011)

The virus is spherical, has single-stranded RNA, and 2 surface glycoproteins F (fusion) and H (hemagglutinin).

Measles Virus ProteinsMolecular Models

The measles virus enters into respiratory tract, it enters the union of the F glycoprotein CD46 receptor, releasing the virus capsid and transcribed by the viral polymerase in the host cytoplasm.

Measles Viral Protein Movement Described ScienceDaily (Jan. 10, 2011)

Recently, we discovered that the virus comes in two pairs of binding proteins, one that interacts with the cell receptor and the other begins the infection process.

Cell receptors

Measles Viral Protein Movement Described ScienceDaily (Jan. 10, 2011)

With an artificial receptor is looking to find the effect in viral proteins had genuine achievement and equally begin the process of infectionby the virus.

Measles Virus attacking a cell

OBSERVATION

Blocking the action of the virus at the start of infection and preventing the atuened virus with his own risks.

New vaccines that can be design to prevent measles viral proteins join with cell receptors.

The form of a synthetic receptor protein.

HPV’s are DNA viruses of Papovaviridae family, has a double-strandred circular DNA.

How Protein Made by Human Papillomavirus Teams Up on and

Thwarts Protective Human Protein ScienceDaily (Jan. 11, 2011)

It had identified over 200 types many of they cause warts, lesions and others are oncogenic.

HPV is directly responsible for thousands of cases each year, through the production of oncoproteins E6 and E7.

In some cases the infection by the HPV virus is highly oncogenic, especially those who develop cervical cancer.

How Protein Made by Human Papillomavirus Teams Up on and

Thwarts Protective Human Protein ScienceDaily (Jan. 11, 2011)

The E6 and E7 proteins disrupt programmed cell death, wich causes the infected cell remains divided into a malignant tissue.

How Protein Made by Human Papillomavirus Teams Up on and

Thwarts Protective Human Protein ScienceDaily (Jan. 11, 2011)

In each sector binds one E6 protein. This helps to understand the initiation of the molecular interactions of the HPV.

The use of the SAP97 epithelial protein inthe research shows that E6 protein binds rapidly in three sectors of the SAP97 protein.

How Protein Made by Human Papillomavirus Teams Up on and

Thwarts Protective Human Protein ScienceDaily (Jan. 11, 2011)

E6 and E7 proteins

Cell cycle

OBSERVATION

Preventing further infection, years probably later develop into cancer.

The way the virus works can influence the way how to destroy it by taking advantage of the virus on the cell.

Turning it into a therapeutic advantage avoiding it is a blocking their binding sites.

MEDICAL UTILITY

Proteins are biomolecules of organism used for many areas of health.

New forms of diagnosis

New therapeutic targets

New markers of  new diseases

Activity, presence or defects affecting the overall condition of a patient.

MEDICAL UTILITY

There are techniques that differentiate us from becoming a more specific way what we are looking for.

These seek to take advantage of each technique the properties of proteins.

Chemical reactions

Difference of charges Concentration gradients

Immune reactions

MEDICAL UTILITY

It is important to reseach in microbiology proteins.

To take advantage of what we develop in favor of Medicine…And fight them!

We can understand many of the processes of this

nature.

MEDICAL UTILITY

Simpler

More Accessible

More Effective

More Specific

It is expected that future with the help of research and scientific advances that biotech progress.

BIBLIOGRAPHY

• MARTINEZ SÁNCHEZ, Lina María. Biología Molecular. 6ta. ed. Medellín: UPB. Fac. de Medicina, 2011. 313 p.

• LODISH, H. Biología Celular y Molecular. 5 ed. Buenos Aires: Médica Panamericana. 2004. 973 p.

• http://www.sciencedaily.com/releases/2011/01/110109184017.htm

• http://www.sciencedaily.com/releases/2011/01/110111133021.htm

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