Population-Based Biobanks in a Population-Based Biobanks in a Global ContextGlobal Context

FP7, Grant Agreement Nr. 212111

Dr. Markus Perola, MD, PhDDr. Markus Perola, MD, PhDWP 2WP 2

WP leader Prof Leena PeltonenWP leader Prof Leena PeltonenWP leader Prof Anders MetspaluWP leader Prof Anders Metspalu

Population-based biobanks in BBMRI

The mission of WP2 of BBMRI is to provide a strategy for the population-based biobanks to solve the: – legal challenges– Governance challenges– financial challenges

of the utilization of the vast amount of information collected in large epidemiological sample collections and population cohorts brings forth

• European investigators and national health care systems have for decades collected population-based cohorts and health data

• This common treasure is built on the European tax-payer’s money and voluntary participation

• Globally, Europe is still a fore-runner in combining health care information with genomic data

Population-based biobanks in BBMRI

• Harmonizing data across BBMRI biobanks

• Using the structure and data collection strategy identical with those of P3G to facilitate global data comparisons

• 4 epidemiological biobanks have provided detailed information of their content

FP7, Grant Agreement Nr. 212111

Biobank short name Biobank name Country Representative 1. CEPH Biobank Fondation Jean Dausset-CEPH Biological Resource Center France Hélène Blanché

2. EGP The Estonian Genome Project of University of Tartu Estonia Andres Metspalu

3. HUNT Biobank HUNT Biobank Norway Kristian Hveem

4. KORA-gen KORA-gen - Cooperative Health Research in the Region of Augsburg

Germany Melanie Kolz

5. NPHI National Public Health Institute Finland Markus Perola

6. UK Biobank UK Biobank: Protocol for a large-scale prospective epidemiological resource

UK Tim peakman

7. UMCG University Hospital Groningen Netherlands Bruce Wolffenbuttel

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BBMRI Pilot Network

““A pilot network of A pilot network of population-based biobanks population-based biobanks

– obesity as the model – obesity as the model phenotype”phenotype”

FP7, Grant Agreement Nr. 212111

• Can the etiologic background of obesity be approached by using samples/data from several biobanks with different settings?– Obesity was chosen as it is an enormously important

public health problem and as it can well demonstrate several problems:

• Challenges in consensus definition/criteria for the phenotype

• Quantity and quality of life style data collected

• Extent and reliability of family history

• Diversity /quality criteria of the laboratory data

• Age of the population studied and the follow up time

• DNA SAMPLES, Tubes, Storage plates (96 format), Storage format, 2D coded storage plates (96 format), Dry storage (FTA/ GenVault), Other, Barcodes, Sample, 2D codes, tracing, Printed labels, Hand written labels, Automated storage & retrieval of samples, Manual retrieval of samples, Sample storage facilities/ sample retrieval, Access control monitored, Temperature monitoring (automated alarm in case of thawing), Response time to alarm, Commercial, LIMS, Modified commercial, Developed in-house, No LIMS available, Sample logistics (recieval, distribution, locations), DNA extraction, LIMS processes covered, Sample aliquoting, Sample freeze thaw cycles, Inventory, Sample quality, Sample quantity, Sample receival, DNA extraction, Sample aliquoting, SOPs for laboratory staff, Sample quantity check, Sample quality check, Sample inventory, Sample shipment, Sample return, Sample MTA, Sample delivery policies, Samples returned back to biobank after analysis, Quality checked after samples returned back to the biobank, Quality checked after samples returned back to the biobank

Review of technical solutions Review of technical solutions and quality criteriaand quality criteria

• BBMRI presents a review of technical solutions and quality criteria for storage, retrieval and transfer of DNA samples in 5 different networking biobanks – Estonia, Finland, Germany, Netherlands and Norway– The review is based on the previous studies by the P3G

observatory as well as the procedures currently employed in the

BBMRI´s pilot networking biobanks.

FP7, Grant Agreement Nr. 212111

Review of technical solutions Review of technical solutions and quality criteriaand quality criteria

FP7, Grant Agreement Nr. 212111

P3G – BBMRI –synergy through collaboration

www.p3gobservatory.org

The population-based biobanks exist for the advancement of health of Europeans!